#Release Date: 2020-2-12
id	pmid	geneids	genes	sentence	type	solid
1	10021299	7157;1026	p53;WAF1	The functional ***link*** between ***p53*** and ***WAF1*** suggests the possibility that alteration in WAF1 function constitutes an alternative mechanism to p53 inactivation .	parallel	0
2	10021336	1908;284217	endothelin-3;laminin alpha1	In contrast , transcription of ***laminin alpha1*** , a smooth muscle-derived promoter of neuronal development , was ***inhibited*** by ***endothelin-3*** , but promoted by BQ 788 .	negative	1
3	10021362	5727;6608	Ptc;Smo	The ***inhibition*** of ***Smo*** by ***Ptc*** can be relieved by the addition of Shh .	negative	1
4	10021362	6608;5727	Smo;Ptc	Mapping of the Smo domains required for binding to Ptc and for signaling revealed that the ******Smo-Ptc****** ***interaction*** involves mainly the amino terminus of Smo , and that the third intracellular loop and the seventh transmembrane domain are required for signaling .	parallel	1
5	10021362	5727;6608	Ptc;Smo	CONCLUSIONS : These data demonstrate that Smo is the signaling component of a multicomponent Hh receptor complex and that ***Ptc*** is a ligand-regulated ***inhibitor*** of ***Smo*** .	negative	1
6	10021367	10097;10096	Arp2;Arp3	To date , several actin-cytoskeleton-associated proteins have been implicated in the motility of Listeria or Shigella : vasodilator-stimulated phosphoprotein ( VASP ) , vinculin and the actin-related protein ***complex*** of ***Arp2*** and ***Arp3*** [ 4 ] [ 5 ] [ 6 ] [ 7 ] .	parallel	1
7	10021463	596;4790	Bcl-2;NF-kappaB	In addition , ***Bcl-2*** or Bcl-XL ***inhibits*** activation of ***NF-kappaB*** and thus upregulation of proinflammatory genes .	negative	1
8	10021463	598;4790	Bcl-XL;NF-kappaB	In addition , Bcl-2 or ***Bcl-XL*** ***inhibits*** activation of ***NF-kappaB*** and thus upregulation of proinflammatory genes .	negative	1
9	10021463	596;4790	Bcl-2;NF-kappaB	***Bcl-2-mediated*** ***inhibition*** of ***NF-kappaB*** in EC occurs upstream of IkappaBalpha degradation without affecting p65-mediated transactivation .	negative	1
10	10021466	3329;4790	HSP 60;NF-kappaB	In ECs , either ***HSP 60*** ***triggered*** activation of ***NF-kappaB*** complexes containing p65 and p50 Rel proteins .	positive	0
11	10022118	836;1026	caspase-3;p21	We report herein that ***p21*** was ***cleaved*** by ***caspase-3/CPP32*** at the site of DHVD112L during the DNA damage-induced apoptosis of cancer cells .	target	1
12	10022118	836;1026	caspase-3;p21	Thus , ***caspase-3-mediated*** ***cleavage*** and inactivation of ***p21*** protein may convert cancer cells from growth arrest to undergoing apoptosis , leading to the acceleration of chemotherapy-induced apoptotic process in cancer cells .	target	1
13	10022120	7535;868	Zap-70;Cbl-b	In heterogeneous COS-1 cells , ***Cbl-b*** was ***phosphorylated*** on tyrosine residues by both Syk - ( ***Syk/Zap-70*** ) and Src - ( Fyn/Lck ) family kinases , with Syk kinase inducing the most prominent effect .	target	1
14	10022120	868;2885	Cbl-b;Grb2	***Cbl-b*** constitutively ***binds*** ***Grb2*** and becomes associated with Crk-L upon TCR stimulation .	parallel	1
15	10022123	7157;4609	p53;C-myc	***C-myc*** overexpression and ***p53*** loss ***cooperate*** to promote genomic instability .	parallel	0
16	10022234	3458;3717	IFNgamma;Jak2	LPS caused intranuclear translocation of NF-kappaB , and ***IFNgamma*** ***induced*** phosphorylation of ***Jak2*** and Stat1 , followed by the translocation of Stat1 into the nucleus .	target	1
17	10022234	3458;6772	IFNgamma;Stat1	LPS caused intranuclear translocation of NF-kappaB , and ***IFNgamma*** ***induced*** phosphorylation of Jak2 and ***Stat1*** , followed by the translocation of Stat1 into the nucleus .	target	1
18	10022303	356;355	FasL;Fas	Both ***Fas*** ***ligand*** ( ***FasL*** ) and Fas receptor ( Fas ) were expressed postnatally in rat testis with peak expression associated with the high levels of germ cell apoptosis found during the first wave of spermatogenesis .	parallel	1
19	10022379	5328;5329	uPA;uPAR	The latter antibody was capable of binding the preformed complex , forming a transient trimolecular assembly , and promoting the dissociation of the ******uPA/uPAR****** ***complex*** .	parallel	1
20	10022386	7409;5599	Vav;JNK	Expression of GFP ***tagged-Vav*** , an ***activator*** of stress-activated protein kinase ( ***SAPK/JNK*** ) , resulted in the expected induction of JNK activity and in the normal redistribution of Vav in response to engagement of the high affinity receptor for IgE ( FcepsilonRI ) .	positive	1
21	10022386	7409;5601	Vav;SAPK	Expression of GFP ***tagged-Vav*** , an ***activator*** of stress-activated protein kinase ( ***SAPK/JNK*** ) , resulted in the expected induction of JNK activity and in the normal redistribution of Vav in response to engagement of the high affinity receptor for IgE ( FcepsilonRI ) .	positive	1
22	10022436	3952;3630	Leptin;Proinsulin	***Proinsulin*** messenger ribonucleic acid expression in islets was ***inhibited*** by ***Leptin*** at 11.1 mM , but not at 5.6 mM glucose .	negative	1
23	10022436	3952;3630	Leptin;Proinsulin	***Leptin*** also ***reduced*** ***Proinsulin*** messenger ribonucleic acid levels that were increased in islets by treatment with 10 nM glucagon-like peptide-1 in the presence of either 5.6 or 11.1 mM glucose .	negative	1
24	10022437	3558;5617	Interleukin-2;prolactin	***Interleukin-2*** ***inhibits*** the synthesis and release of ***prolactin*** from human decidual cells .	negative	1
25	10022437	3558;5617	Interleukin-2;PRL	As ***Interleukin-2*** ( IL-2 ) ***stimulates*** the synthesis and release of pituitary ***PRL*** , and decidual stromal cells have receptors for IL-2 , we examined whether IL-2 also regulates the release of decidual PRL .	positive	0
26	10022437	3558;5617	IL-2;PRL	These findings strongly suggest that ***IL-2*** ***inhibits*** the synthesis and release of decidual ***PRL*** and provide further support for a critical role of cytokines in the regulation of decidual PRL gene expression .	negative	1
27	10022504	6750;3558	Somatostatin;interleukin-2	Neuropeptide ***Somatostatin*** ( SRIF ) has been shown to ***modulate*** ***interleukin-2*** ( IL-2 ) secretion by mitogen-activated T cells .	target	0
28	10022505	3458;4609	IFNgamma;c-Myc	We found that whereas ***IFNgamma*** ***inhibits*** CSF-1-stimulated ***c-Myc*** gene expression , it induces Mad1 expression .	negative	1
29	10022505	4609;4149	Myc;Max	These results suggest that IFNgamma treatment could shift the ******Myc-Max****** ***complex*** to the Mad1-Max complex in cells .	parallel	1
30	10022505	4084;4149	Mad1;Max	These results suggest that IFNgamma treatment could shift the Myc-Max complex to the ******Mad1-Max****** ***complex*** in cells .	parallel	1
31	10022507	8600;4982	OPGL;Osteoprotegerin	***Osteoprotegerin*** ( OPG ) and its ***ligand*** ( ***OPGL*** ) negatively and positively regulate osteoclastogenesis in the mouse .	parallel	1
32	10022507	4982;8600	OPG;OPGL	***OPG*** ( 5-250 ng/ml ) ***antagonizes*** the effects of ***OPGL*** on the morphology of the osteoclast-like cells that form , as well as bone erosion .	negative	1
33	10022541	2641;3099	glucagon;HK II	Moreover , treatment of the transfectants with glucagon did not inhibit promoter activation in the transformed H661 cells , while endogenous ***HK II*** in NHBECs is ***suppressed*** by ***glucagon*** .	negative	1
34	10022686	7157;1026	p53;CIP1	CONCLUSIONS : Our results indicate that ***p21WAF-1-CIP1*** seems to be ***regulated*** by ***p53*** independent pathways in superficial bladder cancer .	target	1
35	10022686	7157;1026	p53;p21	Among p21 positive tumors 15 ( 65.2 % ) were p53 and p21 positive , suggesting that ***p21*** may also be ***regulated*** by ***p53*** independent pathways .	target	1
36	10022737	3440;1437	interferon alpha-2B;GM-CSF	RESULTS : BCG and/or ***interferon alpha-2B*** differentially ***increased*** IL-1beta , IL-6 , IL-8 , ***GM-CSF*** and TNF-alpha production in the bladder cancer cells .	positive	0
37	10022737	3440;3553	interferon alpha-2B;IL-1beta	RESULTS : BCG and/or ***interferon alpha-2B*** differentially ***increased*** ***IL-1beta*** , IL-6 , IL-8 , GM-CSF and TNF-alpha production in the bladder cancer cells .	positive	0
38	10022737	3440;3569	interferon alpha-2B;IL-6	RESULTS : BCG and/or ***interferon alpha-2B*** differentially ***increased*** IL-1beta , ***IL-6*** , IL-8 , GM-CSF and TNF-alpha production in the bladder cancer cells .	positive	0
39	10022737	3440;3576	interferon alpha-2B;IL-8	RESULTS : BCG and/or ***interferon alpha-2B*** differentially ***increased*** IL-1beta , IL-6 , ***IL-8*** , GM-CSF and TNF-alpha production in the bladder cancer cells .	positive	0
40	10022737	3440;7124	interferon alpha-2B;TNF-alpha	RESULTS : BCG and/or ***interferon alpha-2B*** differentially ***increased*** IL-1beta , IL-6 , IL-8 , GM-CSF and ***TNF-alpha*** production in the bladder cancer cells .	positive	0
41	10022737	3440;7040	interferon alpha-2B;TGF-beta1	The combination of BCG and ***interferon alpha-2B*** also completely ***suppressed*** ***TGF-beta1*** production in the MGH and RT112 cell lines .	negative	1
42	10022739	4233;3082	MET;HGF	PURPOSE : Several lines of evidence show that hepatocyte growth factor ( ***HGF*** ) and its ***receptor*** ***MET*** play a significant role in the progression of various cancers including renal cell carcinoma ( RCC ) .	parallel	1
43	10022764	8204;5465	RIP140;PPARalpha	However , protein binding studies carried out in vitro showed that full-length ***RIP140*** ***bound*** efficiently to ***PPARalpha*** in the absence of exogenously added ligand .	parallel	1
44	10022764	8204;6256	RIP140;retinoid-X-receptor alpha	In contrast , a strong ***interaction*** of ***RIP140*** with the PPARalpha and LXRalpha heterodimerization partner ***retinoid-X-receptor alpha*** ( RXRalpha ) required the presence of its cognate ligand , 9-cis retinoic acid .	parallel	1
45	10022777	5578;2690	protein kinase C alpha;growth hormone-binding protein	Activation of ***protein kinase C alpha*** ***enhances*** human ***growth hormone-binding protein*** release .	positive	0
46	10022812	6237;5898	Rap1/Ras;Ral	In COS cells , Ral GDP dissociation stimulator ( RalGDS ) - induced ***Ral*** activation was ***stimulated*** by RasG12V or a ***Rap1/Ras*** chimera in which the N-terminal region of Rap1 was ligated to the C-terminal region of Ras but not by Rap1G12V or a Ras/Rap1 chimera in which the N-terminal region of Ras was ligated to the C-terminal region of Rap1 , although RalGDS interacted with these small GTP-binding proteins .	positive	0
47	10022814	2885;5609	Grb2;MEK	Upon activation , RTKs may transmit their oncogenic signals by binding to the growth factor receptor bound protein-2 ( ***Grb2*** ) , which in turn binds to SOS and ***activates*** the ***Ras/Raf/MEK*** / mitogen-activated protein ( MAP ) kinase pathway .	positive	1
48	10022815	6667;4605	SP1;B-MYB	The B-MYB-responsive element does not contain myb-binding sites and gel-shift analysis shows that ***SP1*** , but not B-MYB , protein contained in SAOS2 cell extracts ***binds*** to the 120 bp ***B-MYB*** promoter fragment .	parallel	1
49	10022815	4605;6667	B-MYB;SP1	These observations suggest that ***B-MYB*** functions as a ***coactivator*** of ***SP1*** , and that diverse combinations of myb and SP1 sites may dictate the responsiveness of myb-target genes to the various members of the myb family .	positive	1
50	10022833	8651;3815	Socs1;Kit	We show that the expression of Socs1 mRNA is rapidly increased in primary bone marrow-derived mast cells following exposure to steel factor , and ***Socs1*** inducibly ***binds*** to the ***Kit*** receptor tyrosine kinase via its Src homology 2 ( SH2 ) domain .	parallel	1
51	10022833	8651;3815	Socs1;Kit	In contrast , constitutive expression of ***Socs1*** ***suppresses*** the mitogenic potential of ***Kit*** while maintaining steel factor-dependent cell survival signals .	negative	1
52	10022833	8651;7409	Socs1;Vav	We show that Grb2 binds Socs1 via its SH3 domains to putative diproline determinants located in the N-terminus of Socs1 , and ***Socs1*** ***binds*** to the N-terminal regulatory region of ***Vav*** .	parallel	1
53	10022833	2885;8651	Grb2;Socs1	We show that ***Grb2*** ***binds*** ***Socs1*** via its SH3 domains to putative diproline determinants located in the N-terminus of Socs1 , and Socs1 binds to the N-terminal regulatory region of Vav .	parallel	1
54	10022835	4654;1019	MyoD;cdk4	Coupling of the cell cycle and myogenesis through the cyclin D1-dependent ***interaction*** of ***MyoD*** with ***cdk4*** .	parallel	1
55	10022835	1019;4654	cdk4;MyoD	Here we show that a mitogen-sensitive mechanism , involving the direct ***interaction*** between ***MyoD*** and ***cdk4*** , restricts myoblast differentiation to cells that have entered into the G0 phase of the cell cycle under mitogen withdrawal .	parallel	1
56	10022835	4654;1019	MyoD;cdk4	***Interaction*** between ***MyoD*** and ***cdk4*** disrupts MyoD DNA-binding , muscle-specific gene activation and myogenic conversion of 10T1/2 cells independently of cyclin D1 and the CAK activation of cdk4 .	parallel	1
57	10022835	1022;1019	CAK;cdk4	Interaction between MyoD and cdk4 disrupts MyoD DNA-binding , muscle-specific gene activation and myogenic conversion of 10T1/2 cells independently of cyclin D1 and the ***CAK*** ***activation*** of ***cdk4*** .	positive	1
58	10022835	4654;1019	MyoD;cdk4	The specific ******MyoD-cdk4****** ***interaction*** in dividing myoblasts , coupled with the cyclin D1-dependent nuclear targeting of cdk4 , suggests a mitogen-sensitive mechanism whereby cyclin D1 can regulate MyoD function and the onset of myogenesis by controlling the cellular location of cdk4 rather than the phosphorylation status of MyoD .	parallel	1
59	10022835	595;4654	cyclin D1;MyoD	The specific MyoD-cdk4 interaction in dividing myoblasts , coupled with the cyclin D1-dependent nuclear targeting of cdk4 , suggests a mitogen-sensitive mechanism whereby ***cyclin D1*** can ***regulate*** ***MyoD*** function and the onset of myogenesis by controlling the cellular location of cdk4 rather than the phosphorylation status of MyoD .	target	1
60	10022843	6426;6426	SF2;ASF	The splicing factor-associated protein , p32 , regulates RNA splicing by inhibiting ******ASF/SF2****** RNA ***binding*** and phosphorylation .	parallel	1
61	10022843	708;6426	p32;ASF	Here we present evidence that ***p32*** ***interacts*** with ***ASF/SF2*** and SRp30c , another member of the SR protein family .	parallel	1
62	10022843	708;8683	p32;SRp30c	Here we present evidence that ***p32*** ***interacts*** with ASF/SF2 and ***SRp30c*** , another member of the SR protein family .	parallel	1
63	10022843	6426;6426	ASF;SF2	We further show that p32 inhibits ASF/SF2 function as both a splicing enhancer and splicing repressor protein by preventing stable ******ASF/SF2****** ***interaction*** with RNA , but p32 does not block SRp30c function .	parallel	1
64	10022843	708;6426	p32;SF2	We further show that ***p32*** ***inhibits*** ***ASF/SF2*** function as both a splicing enhancer and splicing repressor protein by preventing stable ASF/SF2 interaction with RNA , but p32 does not block SRp30c function .	negative	1
65	10022843	6426;6426	SF2;ASF	Our results suggest that p32 functions as an ASF/SF2 inhibitory factor , regulating ******ASF/SF2****** RNA ***binding*** and phosphorylation .	parallel	1
66	10022848	54536;5870	Sec15p;rab GTPase	***Sec15p*** , an exocyst component , can associate with secretory vesicles and ***interact*** specifically with the ***rab GTPase*** , Sec4p , in its GTP-bound form .	parallel	1
67	10022862	7157;4193	p53;Mdm2	Mutation of the phosphorylation sites to alanine did not affect the sensitivity of p53 to binding to or degradation by Mdm2 , although alteration of residues 15 and 37 to aspartic acid , which could mimic phosphorylation , resulted in a slight resistance to Mdm2-mediated degradation , consistent with recent reports that phosphorylation at these sites inhibits the ******p53-Mdm2****** ***interaction*** .	parallel	1
68	10022865	1029;1019	INK4;CDK4	Here we show that although all four ***INK4*** proteins ***associate*** with ***CDK4*** and CDK6 in vitro , only p16 ( INK4a ) can form stable , binary complexes with both CDK4 and CDK6 in proliferating cells .	parallel	0
69	10022865	1029;1021	INK4;CDK6	Here we show that although all four ***INK4*** proteins ***associate*** with CDK4 and ***CDK6*** in vitro , only p16 ( INK4a ) can form stable , binary complexes with both CDK4 and CDK6 in proliferating cells .	parallel	0
70	10022865	1029;1019	p16;CDK4	Here we show that although all four INK4 proteins associate with CDK4 and CDK6 in vitro , only ***p16*** ( INK4a ) can form stable , binary ***complexes*** with both ***CDK4*** and CDK6 in proliferating cells .	parallel	1
71	10022865	1029;1021	p16;CDK6	Here we show that although all four INK4 proteins associate with CDK4 and CDK6 in vitro , only ***p16*** ( INK4a ) can form stable , binary ***complexes*** with both CDK4 and ***CDK6*** in proliferating cells .	parallel	1
72	10022865	1029;1019	INK4;CDK4	The other ***INK4*** family members form stable complexes with CDK6 but ***associate*** only transiently with ***CDK4*** .	parallel	0
73	10022865	1029;1021	INK4;CDK6	The other ***INK4*** family members form stable ***complexes*** with ***CDK6*** but associate only transiently with CDK4 .	parallel	1
74	10022865	1019;1026	CDK4;p21	Conversely , ***CDK4*** stably ***associates*** with both ***p21*** ( CIP1 ) and p27 ( KIP1 ) in cyclin-containing complexes , suggesting that CDK4 is in equilibrium between INK4 and p21 ( CIP1 ) - or p27 ( KIP1 ) - bound states .	parallel	0
75	10022865	1019;5715	CDK4;p27	Conversely , ***CDK4*** stably ***associates*** with both p21 ( CIP1 ) and ***p27*** ( KIP1 ) in cyclin-containing complexes , suggesting that CDK4 is in equilibrium between INK4 and p21 ( CIP1 ) - or p27 ( KIP1 ) - bound states .	parallel	0
76	10022865	1026;1019	p21;CDK4	In agreement with this hypothesis , overexpression of ***p21*** ( CIP1 ) in 293 cells , where CDK4 is bound to p16 ( INK4a ) , ***stimulates*** the formation of ternary cyclin ***D-CDK4-p21*** ( CIP1 ) complexes .	positive	0
77	10022866	2549;5781	Gab1;SHP2	Following stimulation of epithelial cells with HGF , ***Gab1*** ***associates*** with phosphatidylinositol 3-kinase and the tyrosine phosphatase ***SHP2*** .	parallel	0
78	10022869	4088;4089	Smad3;Smad4	******Smad3-Smad4****** and AP-1 ***complexes*** synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta .	parallel	1
79	10022869	4088;4089	Smad3;Smad4	Here , we describe a concurrent requirement for two discrete responsive elements in the regulation of the c-Jun promoter , one a binding site for a ******Smad3-Smad4****** ***complex*** and the other an AP-1 binding site .	parallel	1
80	10022869	7040;3725	TGF-beta;c-Jun	This simultaneous requirement for two distinct and independent DNA binding elements suggests that Smad and AP-1 complexes function synergistically to mediate ***TGF-beta-induced*** transcriptional ***activation*** of the ***c-Jun*** promoter .	positive	1
81	10022874	8569;1977	Mnk1;eIF4E	Expression of dominant-negative ***Mnk1*** ***reduces*** mitogen-induced ***eIF4E*** phosphorylation , while expression of activated Mnk1 increases basal eIF4E phosphorylation .	negative	1
82	10022874	8569;1977	Mnk1;eIF4E	Activated mutant ***Mnk1*** also ***induces*** extensive phosphorylation of ***eIF4E*** in cells overexpressing 4EBP1 .	target	1
83	10022874	8569;1977	Mnk1;eIF4E	This suggests that phosphorylation of ***eIF4E*** is ***catalyzed*** by ***Mnk1*** or a very similar kinase in cells and is independent of other mitogenic signals that release eIF4E from 4EBP1 .	positive	1
84	10022874	8569;1977	Mnk1;eukaryotic translation initiation factor 4E	***Phosphorylation*** of the cap-binding protein ***eukaryotic translation initiation factor 4E*** by protein kinase ***Mnk1*** in vivo .	target	1
85	10022874	8569;1977	Mnk1;eIF4E	We previously showed that a mitogen - and stress-activated kinase , ***Mnk1*** , ***phosphorylates*** ***eIF4E*** in vitro at the physiological site .	target	1
86	10022874	8569;1977	Mnk1;eIF4E	Here we show that ***Mnk1*** ***regulates*** ***eIF4E*** phosphorylation in vivo .	target	1
87	10022874	8569;1981	Mnk1;eIF4G	***Mnk1*** ***binds*** directly to ***eIF4G*** and copurifies with eIF4G and eIF4E .	parallel	1
88	10022875	207;5594	Rac;ERK	All combinations of ***Rac/Raf*** and Ras/Raf and Rho/Raf effector mutants that transform cells cooperatively ***stimulated*** ***ERK*** .	positive	0
89	10022879	2099;2100	ERalpha;ERbeta	Using ER subunits with modified DNA recognition specificity , we were able to measure the transcriptional properties of ******ERalpha-ERbeta****** ***heterodimers*** in transfected cells without interference from the two ER homodimer complexes .	parallel	1
90	10022879	2100;2099	ERbeta;ERalpha	Using ligand-binding and AF-2-defective mutants , we further demonstrated that while the ******ERalpha-ERbeta****** ***heterodimer*** can be activated when only one E2-binding competent partner is present per dimer , two functional AF-2 domains are required for transcriptional activity .	parallel	1
91	10022879	2100;2099	ERbeta;ERalpha	Taken together , the results of this study of a retinoid X receptor-independent heterodimer complex , the first such study , provide evidence of different stoichiometric requirements for AF-1 and -2 activity and demonstrate that AF-1 receptor-specific properties are maintained within the ******ERalpha-ERbeta****** ***heterodimer*** .	parallel	1
92	10022882	3553;4790	IL-1beta;NF-kappaB	This pathway involves the Rac1 and Cdc42 GTPases , two enzymes which are not required for ***NF-kappaB*** ***activation*** by ***IL-1beta*** in epithelial cells .	positive	1
93	10022882	3553;4790	IL-1beta;NF-kappaB	In conclusion , three different cell-specific pathways lead to ***NF-kappaB*** ***activation*** by ***IL-1beta*** : a pathway dependent on ROI production by 5-LOX in lymphoid cells , an ROI - and 5-LOX-independent pathway in epithelial cells , and a pathway requiring ROI production by NADPH oxidase in monocytic cells .	positive	1
94	10022883	3084;6667	Neu differentiation factor;Sp1 transcription factor	***Neu differentiation factor*** ***stimulates*** phosphorylation and activation of the ***Sp1 transcription factor*** .	positive	0
95	10022897	356;355	CD95L;Fas	Fas ( CD95 ) and ***Fas*** ***ligand*** ( ***CD95L*** ) are an interacting receptor-ligand pair required for immune homeostasis .	parallel	1
96	10022897	4790;5970	p50;p65	Electrophoretic mobility shift assay ( EMSA ) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible binding of ******p50-p65****** NF-kappaB ***heterodimers*** after P/I activation .	parallel	1
97	10022897	4790;4790	p50;NF-kappaB	Electrophoretic mobility shift assay ( EMSA ) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible ***binding*** of ***p50-p65*** ***NF-kappaB*** heterodimers after P/I activation .	parallel	1
98	10022897	4790;5970	p50;p65	Electrophoretic mobility shift assay ( EMSA ) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible ***binding*** of ******p50-p65****** NF-kappaB heterodimers after P/I activation .	parallel	1
99	10022897	5970;4790	p65;NF-kappaB	Electrophoretic mobility shift assay ( EMSA ) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible ***binding*** of ***p50-p65*** ***NF-kappaB*** heterodimers after P/I activation .	parallel	1
100	10022898	1026;1017	p21;Cdk2	We show that the Cdk inhibitor ***p21*** ( Sdi1 , Cip1 , Waf1 ) , which accumulates progressively in aging cells , ***binds*** to and inactivates all cyclin ***E-Cdk2*** complexes in senescent cells , whereas in young cells only p21-free Cdk2 complexes are active .	parallel	1
101	10022898	1019;595	Cdk4;cyclin D1	Instead , the ******cyclin D1-Cdk4****** and cyclin D1-Cdk6 ***complexes*** in these cells are associated with an increased amount of p21 , suggesting that p21 may be responsible for inactivation of both cyclin E - and cyclin D1-associated kinase activity at the early stage of senescence .	parallel	1
102	10022898	1021;595	Cdk6;cyclin D1	Instead , the cyclin D1-Cdk4 and ******cyclin D1-Cdk6****** ***complexes*** in these cells are associated with an increased amount of p21 , suggesting that p21 may be responsible for inactivation of both cyclin E - and cyclin D1-associated kinase activity at the early stage of senescence .	parallel	1
103	10022898	1019;1026	Cdk4;p21	Instead , the ***cyclin D1-Cdk4*** and cyclin D1-Cdk6 complexes in these cells are ***associated*** with an increased amount of ***p21*** , suggesting that p21 may be responsible for inactivation of both cyclin E - and cyclin D1-associated kinase activity at the early stage of senescence .	parallel	0
104	10022898	1021;1026	Cdk6;p21	Instead , the cyclin D1-Cdk4 and ***cyclin D1-Cdk6*** complexes in these cells are ***associated*** with an increased amount of ***p21*** , suggesting that p21 may be responsible for inactivation of both cyclin E - and cyclin D1-associated kinase activity at the early stage of senescence .	parallel	0
105	10022898	595;1026	cyclin D1;p21	Instead , the cyclin D1-Cdk4 and ***cyclin D1-Cdk6*** complexes in these cells are ***associated*** with an increased amount of ***p21*** , suggesting that p21 may be responsible for inactivation of both cyclin E - and cyclin D1-associated kinase activity at the early stage of senescence .	parallel	0
106	10022904	7124;3551	TNF-alpha;IKKbeta	In contrast , the inhibition of alphaPKC does not affect the ***activation*** of ***IKKbeta*** by ***TNF-alpha*** .	positive	1
107	10022911	3925;8201	Op18;MTs	It was originally proposed that ***Op18*** specifically ***regulates*** dynamic properties of ***MTs*** by associating with tubulin , but it has subsequently been proposed that Op18 acts simply by sequestering of tubulin heterodimers .	target	1
108	10022914	26155;2185	Nir;PYK2	The three ***Nir*** proteins ( Nir1 , Nir2 , and Nir3 ) ***bind*** to the amino-terminal domain of ***PYK2*** via a conserved sequence motif located in the carboxy terminus .	parallel	1
109	10022914	26155;2185	Nir;PYK2	In addition , ******PYK2-Nir****** ***complexes*** are detected in lysates prepared from cultured cells or from brain tissues .	parallel	1
110	10022917	6227;3921	RpS21;P40	***RpS21*** can ***interact*** strongly with ***P40*** , a ribosomal peripheral protein encoded by the stubarista ( sta ) gene .	parallel	1
111	10022923	7157;1026	p53;p21	However , the p53-dependent G1 checkpoint was intact as assessed by functional activation of p53 protein in response to ionizing radiation and subsequent ***p53-mediated*** ***induction*** of ***p21*** ( Waf1/Cip1/Sdi1 ) .	target	1
112	10022926	8900;1869	cyclin A1;E2F-1	The in vitro ***interaction*** of ***cyclin A1*** with ***E2F-1*** was greatly enhanced when cyclin A1 was complexed with CDK2 .	parallel	1
113	10022926	8900;1017	cyclin A1;CDK2	The in vitro interaction of cyclin A1 with E2F-1 was greatly enhanced when ***cyclin A1*** was ***complexed*** with ***CDK2*** .	parallel	1
114	10022926	8900;1869	cyclin A1;E2F-1	***Associations*** of ***cyclin A1*** with Rb and ***E2F-1*** were observed in vivo in several cell lines .	parallel	0
115	10022926	8900;1017	cyclin A1;CDK2	When cyclin A1 was coexpressed with CDK2 in sf9 insect cells , the ******CDK2-cyclin A1****** ***complex*** had kinase activities for histone H1 , E2F-1 , and the Rb family of proteins .	parallel	1
116	10022928	3458;834	IFN-gamma;caspase 1	Furthermore , ***IFN-gamma*** ***induced*** a higher level of ***caspase 1*** expression in Shp-2 ( - / - ) cells than in wild-type cells .	target	1
117	10022929	3987;3611	PINCH;integrin-linked kinase	The LIM-only protein ***PINCH*** directly ***interacts*** with ***integrin-linked kinase*** and is recruited to integrin-rich sites in spreading cells .	parallel	1
118	10022929	3611;3987	ILK;PINCH	The ***interaction*** between ***ILK*** and ***PINCH*** has been consistently observed under a variety of experimental conditions .	parallel	1
119	10022929	3611;3987	ILK;PINCH	The ******PINCH-ILK****** ***interaction*** is mediated by the N-terminal-most LIM domain ( LIM1 , residues 1 to 70 ) of PINCH and multiple ankyrin ( ANK ) repeats located within the N-terminal domain ( residues 1 to 163 ) of ILK .	parallel	1
120	10022950	652;2247	BMP-4;bFGF	BMP-2 plus bFGF also induced numerous leukocytes and fewer erythrocytes , but ***BMP-4*** ***antagonized*** the leukopoietic effect of ***bFGF*** .	negative	1
121	10023011	596;947	Bcl-2;CD34	***Bcl-2*** over-expression is ***associated*** with ***CD34*** positivity , poor response to chemotherapy and reduced overall survival in AML patients .	parallel	0
122	10023660	8945;8454	beta-Trcp;Cul1	The human F box protein ***beta-Trcp*** ***associates*** with the ***Cul1/Skp1*** complex and regulates the stability of beta-catenin .	parallel	0
123	10023660	8945;6500	beta-Trcp;Skp1	The human F box protein ***beta-Trcp*** ***associates*** with the ***Cul1/Skp1*** complex and regulates the stability of beta-catenin .	parallel	0
124	10023660	6500;8454	Skp1;Cul1	The human F box protein beta-Trcp associates with the ******Cul1/Skp1****** ***complex*** and regulates the stability of beta-catenin .	parallel	1
125	10023660	8945;1499	beta-Trcp;beta-catenin	The human F box protein ***beta-Trcp*** associates with the Cul1/Skp1 complex and ***regulates*** the stability of ***beta-catenin*** .	target	1
126	10023660	8945;1499	beta-Trcp;beta-catenin	Consistent with recent reports indicating that Xenopus and Drosophila beta-Trcp homologs act as negative regulators of the Wnt/beta-catenin signaling pathway , we report here that human ***beta-Trcp*** ***interacts*** with ***beta-catenin*** in vivo .	parallel	1
127	10023660	8945;1499	beta-Trcp;beta-catenin	Furthermore , ***beta-catenin*** is specifically ***stabilized*** in vivo by the expression of a dominant negative ***beta-Trcp*** .	positive	0
128	10023668	7704;890	PLZF;cyclin A2	***PLZF*** can ***bind*** and repress the ***cyclin A2*** promoter while expression of cyclin A2 reverts the growth suppressed phenotype of myeloid cells expressing PLZF .	parallel	1
129	10023669	5371;7341	PML;SUMO-1	***PML*** and Sp100 proteins are covalently ***linked*** to ***SUMO-1*** , and ubiquitin-like peptide .	parallel	0
130	10023669	6672;7341	Sp100;SUMO-1	PML and ***Sp100*** proteins are covalently ***linked*** to ***SUMO-1*** , and ubiquitin-like peptide .	parallel	0
131	10023673	8312;1499	Axin;beta-catenin	***Axin*** ***prevents*** Wnt-3a-induced accumulation of ***beta-catenin*** .	negative	0
132	10023673	6934;1499	Tcf-4;beta-catenin	Axin also suppressed Wnt-3a-dependent activation of ***Tcf-4*** which ***binds*** to ***beta-catenin*** and acts as a transcription factor .	parallel	1
133	10023673	8312;6934	Axin;Tcf-4	***Axin*** also ***suppressed*** Wnt-3a-dependent activation of ***Tcf-4*** which binds to beta-catenin and acts as a transcription factor .	negative	1
134	10023675	4066;4790	LYL1;p105	Physical ***interaction*** of the bHLH ***LYL1*** protein and NF-kappaB1 ***p105*** .	parallel	1
135	10023675	4066;4790	LYL1;p105	The ***association*** between ***LYL1*** and ***p105*** was confirmed both in vitro and in vivo in mammalian cells .	parallel	0
136	10023677	861;3562	AML1;IL-3	Our results demonstrate that ***TEL-AML1*** ***represses*** basal ***IL-3*** promoter activity in lymphoid cells , and deletion mutant analysis identified three distinct domains of TEL-AML1 that are required for repression ; the HLH ( pointed ) motif contained in the TEL portion of TEL-AML1 , and both the runt homology domain ( Rhd ) and the 74 amino acids downstream of the Rhd that are present in the AML1 portion of the fusion protein .	negative	1
137	10023677	2120;3562	TEL;IL-3	Our results demonstrate that ***TEL-AML1*** ***represses*** basal ***IL-3*** promoter activity in lymphoid cells , and deletion mutant analysis identified three distinct domains of TEL-AML1 that are required for repression ; the HLH ( pointed ) motif contained in the TEL portion of TEL-AML1 , and both the runt homology domain ( Rhd ) and the 74 amino acids downstream of the Rhd that are present in the AML1 portion of the fusion protein .	negative	1
138	10023679	1457;328	CKII;REF-1	***Phosphorylation*** of the DNA repair protein ***APE/REF-1*** by ***CKII*** affects redox regulation of AP-1 .	target	1
139	10023679	1457;328	CKII;REF-1	Here we demonstrate that ***APE/REF-1*** is ***phosphorylated*** by casein kinase II ( ***CKII*** ) .	target	1
140	10023679	1457;328	CKII;REF-1	***CKII*** ***mediated*** phosphorylation of ***APE/REF-1*** and concomitant increase in AP-1 binding activity appears to be a novel mechanism of cellular stress response , forcing transcription of AP-1 target gene ( s ) the product ( s ) of which may exert protective function .	target	0
141	10023684	7040;1490	TGFbeta;CTGF	***TGFbeta*** ***increased*** ***CTGF*** transcript levels in 2/7 pancreatic cancer cell lines after 4 h of treatment and this elevation was sustained after 24 h.	positive	0
142	10023772	3821;3824	NKG2;CD94	The formation of this dimer reveals a putative ligand-binding region for HLA-E and suggests how ***NKG2*** ***interacts*** with ***CD94*** .	parallel	1
143	10023776	29760;6850	BLNK;Syk	***BLNK*** ( B cell LiNKer protein ) , a ***substrate*** for ***Syk*** , is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK .	parallel	1
144	10023776	29760;5599	BLNK;JNK	As JNK activation requires both Rac1 and PLC gamma 2 , our results suggest that ***BLNK*** ***regulates*** the ***Rac1-JNK*** pathway , in addition to modulating PLC gamma 2 localization .	target	1
145	10023776	29760;5879	BLNK;Rac1	As JNK activation requires both Rac1 and PLC gamma 2 , our results suggest that ***BLNK*** ***regulates*** the ***Rac1-JNK*** pathway , in addition to modulating PLC gamma 2 localization .	target	1
146	10023776	5599;5336	JNK;PLC gamma 2	As ***JNK*** activation ***requires*** both Rac1 and ***PLC gamma 2*** , our results suggest that BLNK regulates the Rac1-JNK pathway , in addition to modulating PLC gamma 2 localization .	target	0
147	10023776	5599;5879	JNK;Rac1	As ***JNK*** activation ***requires*** both ***Rac1*** and PLC gamma 2 , our results suggest that BLNK regulates the Rac1-JNK pathway , in addition to modulating PLC gamma 2 localization .	target	0
148	10023777	3606;3576	IL-18;IL-8	IL-18BP abolished ***IL-18*** ***induction*** of interferon-gamma ( IFNgamma ) , ***IL-8*** , and activation of NF-kappaB in vitro .	target	1
149	10023777	3606;3458	IL-18;interferon-gamma	IL-18BP abolished ***IL-18*** ***induction*** of ***interferon-gamma*** ( IFNgamma ) , IL-8 , and activation of NF-kappaB in vitro .	target	1
150	10023777	3606;4790	IL-18;NF-kappaB	IL-18BP abolished ***IL-18*** ***induction*** of interferon-gamma ( IFNgamma ) , IL-8 , and activation of ***NF-kappaB*** in vitro .	target	1
151	10023777	10068;3606	IL-18BP;IL-18	***IL-18BP*** ***abolished*** ***IL-18*** induction of interferon-gamma ( IFNgamma ) , IL-8 , and activation of NF-kappaB in vitro .	negative	0
152	10023777	10068;3458	IL-18BP;IFNgamma	Administration of ***IL-18BP*** to mice ***abrogated*** circulating ***IFNgamma*** following LPS .	negative	0
153	10023777	10068;51497	IL-18BP;Th1	Thus , ***IL-18BP*** functions as an ***inhibitor*** of the early ***Th1*** cytokine response .	negative	1
154	10023862	3458;941	IFN-gamma;CD80	We concluded that CD80 and CD86 were differentially expressed and modulated on monocytes and the defective ***IFN-gamma-induced*** ***up-regulation*** of ***CD80*** and CD86 expression on SLE monocytes might be a factor in the pathogenesis of SLE .	positive	1
155	10023862	3458;942	IFN-gamma;CD86	We concluded that CD80 and CD86 were differentially expressed and modulated on monocytes and the defective ***IFN-gamma-induced*** ***up-regulation*** of CD80 and ***CD86*** expression on SLE monocytes might be a factor in the pathogenesis of SLE .	positive	1
156	10023862	3586;942	IL-10;CD86	***IL-10*** ***down-regulated*** the expression of ***CD86*** while it slightly enhanced that of CD80 .	negative	1
157	10023862	3458;941	Interferon-gamma;CD80	***Interferon-gamma*** ( IFN-gamma ) ***increased*** both ***CD80*** and CD86 expression on monocytes from both SLE patients and normal groups , albeit less significantly in the former than in the latter , i.e.	positive	0
158	10023862	3458;942	Interferon-gamma;CD86	***Interferon-gamma*** ( IFN-gamma ) ***increased*** both CD80 and ***CD86*** expression on monocytes from both SLE patients and normal groups , albeit less significantly in the former than in the latter , i.e.	positive	0
159	10024310	183;9312	Angiotensin II;kv2.2	***Angiotensin II*** type 1 receptor-mediated ***inhibition*** of K + channel subunit ***kv2.2*** in brain stem and hypothalamic neurons .	negative	1
160	10024503	3949;4018	LDLR;lipoprotein	In the absence of at least the ***low-density-lipoprotein*** ***receptor*** ( ***LDLR*** ) , it was shown that APOC1 overexpression in transgenic mice inhibited the hepatic uptake of VLDL via the LDLR-related protein .	parallel	1
161	10024512	2321;7422	FLT-1;vascular endothelial growth factor	We identified ***vascular endothelial growth factor*** ( VEGF ) and its ***receptor*** fms-like tyrosine kinase ( ***FLT-1*** ) to be under the regulatory control of exogenously applied NO in these cells .	parallel	1
162	10024512	2321;7422	FLT-1;VEGF	Obviously , there is a differential regulation of ***VEGF*** and its ***receptor*** ***FLT-1*** by NO , cytokines and growth factors in rat mesangial cells .	parallel	1
163	10024514	207;5599	Rac;JNK	N17 ***Rac*** non-selectively ***reduced*** ***JNK*** activity by 30 % in resting or stimulated cells ( IL-1 alone , or with PDGF ) .	negative	1
164	10024514	207;5599	Rac;JNK	V12 ***Rac*** weakly ***activated*** ***JNK*** and synergized with IL-1 , but not with PDGF .	positive	1
165	10024514	998;5599	Cdc42;JNK	V12 ***Cdc42*** weakly ***activated*** ***JNK*** , but synergized with PDGF and not IL-1 .	positive	1
166	10024519	6774;2353	STAT3;c-Fos	We have examined the effects of l-thyroxine ( T4 ) on the activation of signal transducer and activator of transcription 3 ( STAT3 ) and on the ***STAT3-dependent*** ***induction*** of ***c-Fos*** expression by epidermal growth factor ( EGF ) .	target	1
167	10024877	2073;4913	XPG;hNth1	***XPG*** protein ***promotes*** binding of ***hNth1*** to damaged DNA .	positive	0
168	10025511	1050;1647	C/EBP alpha;gadd45	Reciprocal ***regulation*** of ***gadd45*** by ***C/EBP alpha*** and c-Myc .	target	1
169	10025511	4609;1647	c-Myc;gadd45	Reciprocal ***regulation*** of ***gadd45*** by C/EBP alpha and ***c-Myc*** .	target	1
170	10025511	1050;1647	C/EBP alpha;gadd45	We report here that ***C/EBP alpha*** directly ***regulates*** ***gadd45*** through a C/EBP-binding site in the proximal promoter .	target	1
171	10025511	1050;1647	C/EBP alpha;gadd45	We also found that c-Myc antagonized ***C/EBP alpha-mediated*** ***transactivation*** of ***gadd45*** .	positive	1
172	10025511	4609;1647	c-Myc;gadd45	We also found that ***c-Myc*** ***antagonized*** C/EBP alpha-mediated transactivation of ***gadd45*** .	negative	1
173	10025673	2885;867	Grb2;Cbl	In the membrane fraction of cells stimulated at 4 degrees C , the ***association*** of p58Shc and ***Grb2*** with ***Cbl*** is stable , whereas its association with Sos and p85 is transient and their dissociation occurs at the time CSF-1 R and Cbl multiubiquitination commence .	parallel	0
174	10025891	596;1029	bcl-2;p16ink4a	Among the cell cycle-related proteins we analyzed , only p21waf1 ***bcl-2*** and CDK4 were significantly and positively ***correlated*** to ***p16ink4a*** .	parallel	0
175	10025891	1019;1029	CDK4;p16ink4a	Among the cell cycle-related proteins we analyzed , only p21waf1 bcl-2 and ***CDK4*** were significantly and positively ***correlated*** to ***p16ink4a*** .	parallel	0
176	10025918	3553;7040	IL-1beta;TGFbeta	RESULTS : ***IL-1beta*** ***increased*** active ***TGFbeta*** in chondrocyte CM by 12 hours ; by 24 hours , significant increases in both active and latent TGFbeta were detectable .	positive	0
177	10026128	3479;4191	IGF-I;MDH	***IGF-I*** ***induced*** PK and ***MDH*** activities in class 1 follicles but negatively influenced PFK activity for class 1 follicles .	target	1
178	10026131	10457;2064	transmembrane glycoprotein;ErbB2	ASGP2 , a ***transmembrane glycoprotein*** found on the surface of the highly metastatic ascites 13762 rat mammary adenocarcinoma cell line , is constitutively ***associated*** with ***ErbB2*** in these cells and in mammary tissue from pregnant rats .	parallel	0
179	10026131	2064;3084	ErbB2;neuregulin-1	Ectopic expression of ASGP2 in human melanoma tumor cells potentiates the ***response*** of endogenous ***ErbB2*** to the ***neuregulin-1*** growth factor .	parallel	0
180	10026136	3483;3486	ALS;IGFBP-3	Ionic interactions are known to be involved in the ***association*** between ***ALS*** and ***IGFBP-3*** .	parallel	0
181	10026138	9474;836	Asp;caspase-3	The pretreatment with ***acetyl-Tyr-Val-Ala-Asp-aldehyde*** , a relatively selective ***inhibitor*** of ***caspase-3*** , or benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( z-VAD .	negative	1
182	10026139	3217;4792	HOXB7;IkappaB-alpha	In this report , we demonstrated that the ***HOXB7*** homeodomain-containing protein , which plays a key role in development and differentiation , physically ***interacted*** in vitro with ***IkappaB-alpha*** , an inhibitor of NF-kappaB activity .	parallel	1
183	10026139	4792;4790	IkappaB-alpha;NF-kappaB	In this report , we demonstrated that the HOXB7 homeodomain-containing protein , which plays a key role in development and differentiation , physically interacted in vitro with ***IkappaB-alpha*** , an ***inhibitor*** of ***NF-kappaB*** activity .	negative	1
184	10026141	3717;23368	Jak2;p85	These results suggest that stimulation of the activity of PI3-kinase induced by GM-CSF is mediated by Jak2 and that the ***association*** between ***Jak2*** and ***p85*** depends on an adaptor protein yet to be identified .	parallel	0
185	10026156	6624;1499	actin-bundling protein;beta-catenin	We have discovered that , as part of this process , the synthetic glucocorticoid dexamethasone strongly and reversibly down-regulated the expression of fascin , an ***actin-bundling protein*** that also ***interacts*** with the adherens junction component ***beta-catenin*** .	parallel	1
186	10026169	8440;25	Grb4;v-Abl	Although neither protein was transforming on its own , both Nck and ***Grb4*** ***cooperated*** with ***v-Abl*** to transform NIH 3T3 cells and influenced the morphology and anchorage-dependent growth of wild type Ras-transformed cells .	parallel	0
187	10026169	4690;25	Nck;v-Abl	Although neither protein was transforming on its own , both ***Nck*** and Grb4 ***cooperated*** with ***v-Abl*** to transform NIH 3T3 cells and influenced the morphology and anchorage-dependent growth of wild type Ras-transformed cells .	parallel	0
188	10026178	3791;7422	VEGFR;Vascular endothelial growth factor	The potential binding site of VEGF with its receptor was identified using cellulose-bound overlapping peptides of the extracytosolic part of the human ***Vascular endothelial growth factor*** ***receptor*** II ( ***VEGFR*** II ) .	parallel	1
189	10026179	4036;5741	Megalin;PTH	Here , we demonstrate that ***Megalin*** , a multifunctional endocytic receptor in the proximal tubular epithelium , ***mediates*** the uptake and degradation of ***PTH*** .	target	0
190	10026179	4036;5741	Megalin;PTH	These data provide evidence that ***Megalin*** is involved in the renal catabolism of PTH and potentially ***antagonizes*** ***PTH/PTHrP*** receptor activity in the proximal tubular epithelium .	negative	1
191	10026184	580;672	BARD1;BRCA1	To characterize functional aspects of the ******BRCA1/BARD1****** ***interaction*** , we have defined the structural domains required for the interaction , as well as their oligomerization state , relative stability , and possible nucleic acid binding activity .	parallel	1
192	10026196	3589;3572	IL-11;gp130	In this study , we have identified residues crucial for the ***binding*** of murine ***IL-11*** ( mIL-11 ) to both the IL-11R and ***gp130*** by examining the activities of mIL-11 mutants in receptor binding and cell proliferation assays .	parallel	1
193	10026205	7040;1490	TGF-beta1;CTGF	High glucose stimulated expression of transforming growth factor beta1 ( TGF-beta1 ) , and addition of ***TGF-beta1*** to mesangial cells ***triggered*** ***CTGF*** expression .	positive	0
194	10026206	959;958	CD154;CD40	Ligation of CD40 on monocytes through its interaction with ***CD40*** ***ligand*** ( ***CD154*** ) present on activated T helper cells , results in activation of monocyte inflammatory cytokine synthesis and rescue of monocytes from apoptosis induced through serum deprivation .	parallel	1
195	10026206	958;3553	CD40;IL-1beta	Together , the data demonstrate that ***CD40-mediated*** ***induction*** of ***IL-1beta*** and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and il-10 .	target	1
196	10026206	958;7124	CD40;tumor necrosis factor-alpha	Together , the data demonstrate that ***CD40-mediated*** ***induction*** of IL-1beta and ***tumor necrosis factor-alpha*** synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and il-10 .	target	1
197	10026208	4773;3170	NFATp;HNF-3beta	A mutational analysis of G2 function and nuclear protein binding as well as the effect of FK506 indicate that calcium responsiveness is conferred to the G2 element by ***NFATp*** functionally ***interacting*** with ***HNF-3beta*** binding to a closely associated site .	parallel	1
198	10026215	190;2516	DAX-1;SF-1	In contrast , overexpression of ***DAX-1*** markedly ***diminished*** the ***SF-1*** mRNA expression , and concomitantly abolished T3-mediated responses .	negative	0
199	10026222	3937;2207	SLP-76;FcR gamma	Immunoprecipitation studies demonstrate ***association*** of ***SLP-76*** with SLAP-130 , Vav , Fyn , Lyn , and the ***FcR gamma-chain*** in CRP-stimulated platelets .	parallel	0
200	10026222	3937;2534	SLP-76;Fyn	Immunoprecipitation studies demonstrate ***association*** of ***SLP-76*** with SLAP-130 , Vav , ***Fyn*** , Lyn , and the FcR gamma-chain in CRP-stimulated platelets .	parallel	0
201	10026222	3937;4067	SLP-76;Lyn	Immunoprecipitation studies demonstrate ***association*** of ***SLP-76*** with SLAP-130 , Vav , Fyn , ***Lyn*** , and the FcR gamma-chain in CRP-stimulated platelets .	parallel	0
202	10026222	3937;2533	SLP-76;SLAP-130	Immunoprecipitation studies demonstrate ***association*** of ***SLP-76*** with ***SLAP-130*** , Vav , Fyn , Lyn , and the FcR gamma-chain in CRP-stimulated platelets .	parallel	0
203	10026223	5590;5594	PKC zeta;ERK	The data are explained by a model in which ***ERK*** activity is ***modulated*** by differential effects of ***PKC zeta*** and PKA on Raf isoforms .	target	0
204	10026224	100506658;7082	occludin;ZO-1	Consistently , ***occludin*** as well as alpha catenin directly ***bound*** to N-ZO-2 as well as the NH2-terminal dlg-like portion of ***ZO-1*** ( N-ZO-1 ) in vitro .	parallel	1
205	10026224	100506658;9414	occludin;ZO-2	Consistently , ***occludin*** as well as alpha catenin directly ***bound*** to ***N-ZO-2*** as well as the NH2-terminal dlg-like portion of ZO-1 ( N-ZO-1 ) in vitro .	parallel	1
206	10026224	9414;100506658	ZO-2;occludin	These findings indicated that ***ZO-2*** forms a ***complex*** with ***ZO-1/occludin*** or ZO-1/alpha catenin to establish TJ or AJ domains , respectively .	parallel	1
207	10026224	9414;7082	ZO-2;ZO-1	These findings indicated that ***ZO-2*** forms a ***complex*** with ***ZO-1/occludin*** or ZO-1/alpha catenin to establish TJ or AJ domains , respectively .	parallel	1
208	10026226	6261;3708	RYR1;IP3 receptor	These results indicate that RYR1 functions as a Ca2 + release channel during BCR-stimulated Ca2 + signaling and suggest that complex Ca2 + signals that control the cellular activities of B cells may be generated by ***cooperation*** of the ***IP3 receptor*** and ***RYR1*** .	parallel	0
209	10026253	998;396	Cdc42;RhoGDI	We propose that this slow step in the observed kinetics reflects the time-course of translocation of the geranyl-geranyl lipid tail of Cdc42 from the outer leaflet of the membrane to the isoprenyl binding site observed in the previously reported NMR structure of the ******Cdc42-RhoGDI****** ***complex*** [ Gosser et al. ( 1997 ) Nature 387 , 814 ] .	parallel	1
210	10026253	396;998	RhoGDI;Cdc42	In this report , we have set out to address this issue by using fluorescence resonance energy transfer approaches to examine the functional ***interactions*** of the ***RhoGDI*** with membrane-associated ***Cdc42*** .	parallel	1
211	10026253	396;998	RhoGDI;Cdc42	This assay allowed us to directly monitor the ***binding*** of ***RhoGDI*** to membrane-associated ***Cdc42*** .	parallel	1
212	10026253	998;396	Cdc42;RhoGDI	Specifically , we propose that the GDI first binds rapidly to membrane-associated Cdc42 and then a slower isomerization occurs which represents the rate-limiting step for the dissociation of the ******Cdc42-RhoGDI****** ***complex*** from membranes .	parallel	1
213	10026256	960;2252	Heparan sulfate proteoglycan;keratinocyte growth factor	***Heparan sulfate proteoglycan*** ***modulates*** ***keratinocyte growth factor*** signaling through interaction with both ligand and receptor .	target	0
214	10026256	2252;2263	KGF;KGFR	In contrast to events on the cell surface , added heparin was not required for high-affinity soluble ******KGF-KGFR****** ***interaction*** .	parallel	1
215	10026303	5970;2353	p65;c-Fos	Moreover , incubating MCF-7 nuclear extracts with antibodies specific for NF-kappa B/p65 or c-Fos in EMSAs almost completely inhibited formation of the complex , supporting the ***association*** of NF-kappa ***B/p65*** and ***c-Fos*** .	parallel	0
216	10026303	5970;2353	p65;c-Fos	Therefore , this study provides evidence that molecular ***interplay*** between the NF-kappa ***B/p65*** and ***c-Fos*** transcription factors exhibits a negative regulatory function on MDR1 promoter by interacting with the CAAT region in MCF-7 .	parallel	1
217	10026833	551;359	AVP;AQP2	Thus , non-osmotic release of ***AVP*** in CHF ***upregulates*** ***AQP2*** water channels , enhances water reabsorption and causes hyponatremia .	positive	1
218	10027007	5979;2668	Ret;glial cell line-derived neurotrophic factor	***Ret*** is the ***receptor*** for ***glial cell line-derived neurotrophic factor*** ( GDNF ) and neurturin ( NTN ) .	parallel	1
219	10027007	5979;4902	Ret;neurturin	***Ret*** is the ***receptor*** for glial cell line-derived neurotrophic factor ( GDNF ) and ***neurturin*** ( NTN ) .	parallel	1
220	10027289	4915;627	TrkB;BDNF	We show here that brain-derived neurotrophic factor ( BDNF ) is present in the HVC of adult males but is not detectable in that of females , though the HVC of both sexes has ***BDNF*** ***receptors*** ( ***TrkB*** ) .	parallel	1
221	10027393	7422;7057	VEGF;thrombospondin-1	In bovine retinal microcapillary endothelial cells , VEGF induced a biphasic response of thrombospondin-1 expression ; ***VEGF*** ***decreased*** ***thrombospondin-1*** mRNA 0.41-fold after 4 hours , whereas it increased , with a threefold peak response , after 24 hours .	negative	0
222	10027393	7422;7057	VEGF;thrombospondin-1	The present findings suggest that , in the ischemic retina , retinal neovascular cells increase thrombospondin-1 expression , and ***VEGF*** may ***stimulate*** endogenous ***thrombospondin-1*** induction , which inhibits endothelial cell growth .	positive	0
223	10027409	84260;1499	tumor suppressor protein;beta-catenin	This suggests a link with disruption of Apc ***tumor suppressor protein-mediated*** ***regulation*** of ***beta-catenin/Tcf-4*** signaling , which is crucial in initiating tumorigenesis .	target	1
224	10027409	84260;6934	tumor suppressor protein;Tcf-4	This suggests a link with disruption of Apc ***tumor suppressor protein-mediated*** ***regulation*** of ***beta-catenin/Tcf-4*** signaling , which is crucial in initiating tumorigenesis .	target	1
225	10027409	1499;6934	beta-catenin;Tcf-4	This suggests a link with disruption of Apc tumor suppressor protein-mediated regulation of ******beta-catenin/Tcf-4****** ***signaling*** , which is crucial in initiating tumorigenesis .	parallel	0
226	10027414	3479;7157	Insulin-like growth factor-1;p53	***Insulin-like growth factor-1*** induces Mdm2 and ***down-regulates*** ***p53*** , attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis .	negative	1
227	10027414	3479;4193	Insulin-like growth factor-1;Mdm2	***Insulin-like growth factor-1*** ***induces*** ***Mdm2*** and down-regulates p53 , attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis .	target	1
228	10027414	7157;183	p53;angiotensinogen	Additionally , ***p53*** DNA ***binding*** to ***angiotensinogen*** ( Aogen ) , AT1 receptor , and Bax was markedly down-regulated by IGF-1 via the induction of Mdm2 and the formation of Mdm2-p53 complexes .	parallel	1
229	10027414	7157;581	p53;Bax	Additionally , ***p53*** DNA ***binding*** to angiotensinogen ( Aogen ) , AT1 receptor , and ***Bax*** was markedly down-regulated by IGF-1 via the induction of Mdm2 and the formation of Mdm2-p53 complexes .	parallel	1
230	10027414	7157;4193	p53;Mdm2	Additionally , p53 DNA binding to angiotensinogen ( Aogen ) , AT1 receptor , and Bax was markedly down-regulated by IGF-1 via the induction of Mdm2 and the formation of ******Mdm2-p53****** ***complexes*** .	parallel	1
231	10027414	3479;7157	IGF-1;p53	Additionally , ***p53*** DNA binding to angiotensinogen ( Aogen ) , AT1 receptor , and Bax was markedly ***down-regulated*** by ***IGF-1*** via the induction of Mdm2 and the formation of Mdm2-p53 complexes .	negative	1
232	10027414	4193;7157	Mdm2;p53	The effects of IGF-1 on cell death , Ang II synthesis , and Bax protein were the consequence of ***Mdm2-induced*** ***down-regulation*** of ***p53*** function .	negative	1
233	10027616	5020;5021	oxytocin;oxytocin receptor	In the present study , we investigated the possible mechanisms by which ***oxytocin*** might ***regulate*** ***oxytocin receptor*** ( OTR ) density .	target	1
234	10027649	3458;10379	IFN-gamma;p48	To understand how ***IFN-gamma*** ***regulates*** the expression of the ***p48*** gene , we have previously isolated and characterized the promoter of murine p48 gene and identified a novel gamma-IFN activated transcriptional element ( GATE ) .	target	1
235	10027715	3700;2353	gp120;c-fos	HIV-1 ***gp120*** ***induces*** the activation of both ***c-fos*** and c-jun immediate-early genes in HEL megakaryocytic cells .	target	1
236	10027715	3700;3725	gp120;c-jun	HIV-1 ***gp120*** ***induces*** the activation of both c-fos and ***c-jun*** immediate-early genes in HEL megakaryocytic cells .	target	1
237	10027778	3586;3558	IL-10;IL-2	Exogenous recombinant ***IL-10*** ***inhibited*** proliferation and ***IL-2*** induction in response to peptide 358-375 .	negative	1
238	10027780	3566;3565	CD124;IL-4	There was no increase in the ***IL-4*** ***receptor*** ( ***CD124*** ) .	parallel	1
239	10027830	7124;1571	TNF-alpha;CYP2E1	CYP2D9 and CYP2E1 activities show differential responses to LPS between wild-type and TNF p55/p75 receptor knockout mice , indicating the down-regulation of CYP2D9 and ***CYP2E1*** is differentially ***modulated*** by ***TNF-alpha*** expression .	target	0
240	10027830	7124;1571	TNF-alpha;CYP2E1	Furthermore , ***TNF-alpha*** appears to ***affect*** the constitutive expression of CYP2D9 and ***CYP2E1*** .	target	0
241	10027904	860;3381	Osf2;BSP	***Osf2*** , a member of the Cbf/runt family of transcription factors , is required for the development of osteoblasts in vivo and has been reported to ***stimulate*** the transcription of ***BSP*** when overexpressed in mesenchymal cell lines .	positive	0
242	10027904	860;3381	Osf2;BSP	These results suggest that ***Osf2*** ***binding*** to the ***BSP*** promoter is not essential for its osteoblast-selective expression .	parallel	1
243	10027928	1356;4353	ceruloplasmin;myeloperoxidase	The ***inhibition*** of ***myeloperoxidase*** by ***ceruloplasmin*** can be reversed by anti-myeloperoxidase antibodies .	negative	1
244	10027928	1356;4353	ceruloplasmin;myeloperoxidase	BACKGROUND : The purpose of this study was to characterize the recently reported ***inhibition*** of ***myeloperoxidase*** ( MPO ) by ***ceruloplasmin*** and to determine whether this may be disturbed in the presence of anti-MPO antibodies .	negative	1
245	10028017	958;959	CD40;CD40L	The ***interaction*** of ***CD40*** on antigen presenting cells ( APC ) with ***CD40L*** on mouse thyroglobulin ( MTg ) - specific T cells may deliver an essential signal for the development of CD4 ( + ) experimental autoimmune thyroiditis ( EAT ) effector cells and anti-MTg producing B cells .	parallel	1
246	10028017	958;959	CD40;CD40L	To determine the requirement for ******CD40-CD40L****** ***interactions*** in G-EAT , donor mice were injected with an anti-CD40L monoclonal antibody ( mAb ) on days -1 , 0 , and +1 relative to immunization with MTg and adjuvant .	parallel	1
247	10028017	958;959	CD40;CD40L	Addition of anti-CD40L during in vitro activation of MTg-primed spleen cells or treatment of recipients with anti-CD40L had no effect on EAT severity , indicating that ******CD40-CD40L****** ***interactions*** are not required after EAT effector cells are primed to MTg .	parallel	1
248	10029063	5727;8643	PTCH1;PTCH2	In situ hybridization revealed high expression of PTCH2 transcripts in both familial and sporadic basal cell carcinomas in similarity to what has been observed for PTCH1 , suggesting a negative ***regulation*** of ***PTCH2*** by ***PTCH1*** .	negative	1
249	10029089	1009;1499	Cadherin-11;beta-catenin	***Cadherin-11*** is localized to a detergent-soluble pool and is ***associated*** with both alpha - and ***beta-catenin*** .	parallel	0
250	10029091	2925;2922	GRP-R;Bombesin	The pathophysiological relevance of the ***Bombesin/GRP*** ***receptor*** ( ***GRP-R*** ) , which is expressed in 30 % of human colon tumor cell lines and in 24-40 % of native tumors , has not been clearly assessed at this time .	parallel	1
251	10029157	3458;1033	Interferon-gamma;cyclin-dependent kinase inhibitor	***Interferon-gamma*** ***impairs*** physiologic downregulation of ***cyclin-dependent kinase inhibitor*** , p27Kip1 , during G1 phase progression in macrophages .	negative	0
252	10029157	1027;1017	p27Kip1;CDK2	The steady , relatively high-level ***attachment*** of ***p27Kip1*** to ***CDK2*** contributed to the insufficient formation of active cyclin/CDK2 , possibly deferring cells from entering S phase .	parallel	0
253	10029158	3553;1440	IL-1beta;granulocyte colony-stimulating factor	***IL-1beta*** ***mediates*** diethyldithiocarbamate-induced ***granulocyte colony-stimulating factor*** production and hematopoiesis .	target	0
254	10029158	3553;1440	IL-1beta;G-CSF	Administration of IL-1 receptor antagonist ( IL-1ra ) to DDTC-treated hLTBMCs obviated the G-CSF induction profile and blocked the resultant colony proliferation , indicating that ***IL-1beta*** ***mediates*** DDTC-induced ***G-CSF*** release and hematopoiesis .	target	0
255	10029247	920;3700	CD4;gp120	CD4-specific monoclonal antibodies ( CG1 , CG7 , and CG8 ) , which bind with a 5 - to 10-fold higher avidity to preformed ******CD4-gp120****** ***complexes*** than to CD4 , were previously shown to recognize newly identified conformational epitopes in the D1-CDR3 region of CD4 .	parallel	1
256	10029247	920;3700	CD4;gp120	In these assays , the CD4-specific MAbs CG1 , -7 , and -8 stabilized the ***association*** of coreceptor , ***gp120*** , and ***CD4*** in trimolecular complexes .	parallel	0
257	10029249	942;941	CD86;CD80	Using this approach , we found an ***association*** between productive infection and increased expression of ***CD80*** and ***CD86*** .	parallel	0
258	10029294	4312;7076	MMP-1;tissue inhibitor of metalloproteinases (TIMP)-1	Our objectives in the present study were to observe the change in the serum MMP-1 protein concentration using recently developed specific enzyme immunoassays for ***MMP-1*** and MMP-1 ***complexed*** with ***tissue inhibitor of metalloproteinases (TIMP)-1*** and to elucidate the clinical usefulness of the serum MMP-1 test in chronic viral hepatitis .	parallel	1
259	10029294	4312;7076	MMP-1;TIMP-1	We measured the serum concentrations of MMP-1 and ******MMP-1/TIMP-1****** ***complex*** using these immunoassays in 64 patients with histologically characterized chronic viral hepatitis .	parallel	1
260	10029294	4312;7076	MMP-1;TIMP-1	The serum concentration of ******MMP-1/TIMP-1****** ***complex*** was also related to the histological severity of chronic hepatitis ( P < 0.0001 ) .	parallel	1
261	10029406	7157;1026	p53;p21	Differential ***regulation*** of ***p21*** by ***p53*** and Rb in cellular response to oxidative stress .	target	1
262	10029409	1019;595	cdk4;cyclin D1	Indeed , G1 cell-cycle arrest was accompanied by reduced induction and nuclear accumulation of the ******cyclin D1-cdk4****** ***complex*** and inhibited nuclear translocation of cdk2 .	parallel	1
263	10029448	1634;7040	decorin;TGF-beta1	TGF-beta1 stimulates the synthesis of decorin , and ***decorin*** is considered to ***bind*** ***TGF-beta1*** .	parallel	1
264	10029448	7040;1634	TGF-beta1;decorin	***TGF-beta1*** ***stimulates*** the synthesis of ***decorin*** , and decorin is considered to bind TGF-beta1 .	positive	0
265	10029448	1634;7040	decorin;TGF-beta1	The activity of decorin in neutralizing TGF-beta1 activity suggests that ***decorin*** serves as a negative-feedback ***regulator*** of ***TGF-beta1*** activity .	target	1
266	10029454	7072;4582	TIA-1;EMA	***TIA-1*** staining strongly ***correlated*** with young patient age ( < or = 32 years , P < .05 ) and ***EMA*** expression ( P < .05 ) .	parallel	0
267	10029562	183;1906	Angiotensin II;endothelin-1	***Angiotensin II*** ***increases*** the release of ***endothelin-1*** from human cultured endothelial cells but does not regulate its circulating levels .	positive	0
268	10029562	183;1906	Angiotensin II;endothelin-1	In contrast , ***Angiotensin II*** ( 10 ( -9 ) , 10 ( -8 ) , 10 ( -7 ) mol/l ) ***stimulated*** ***endothelin-1*** secretion from cultured human vascular endothelial cells derived from umbilical cord veins in a time - and dose-dependent manner .	positive	0
269	10029562	183;1906	Angiotensin II;endothelin-1	Our findings indicate that ***Angiotensin II*** ***regulates*** ***endothelin-1*** release by cultured endothelial cells through an AT1 receptor-dependent pathway , but does not influence circulating endothelin-1 levels in vivo .	target	1
270	10029570	7040;3458	TGF-beta;interferon-gamma	Our data indicate that ***TGF-beta*** ***induced*** an inhibition of ***interferon-gamma*** ( IFN-gamma ) production without affecting the IL-12Rbeta1 and IL-12Rbeta2 subunits mRNA expression by activated T cells .	target	1
271	10029585	2057;2056	EPOR;Erythropoietin	***Erythropoietin*** ( EPO ) and its cell surface ***receptor*** ( ***EPOR*** ) play a central role in proliferation , differentiation , and survival of erythroid progenitors .	parallel	1
272	10029626	3458;355	interferon gamma;CD95	In this study , ***modulation*** of the hepatic ***CD95*** receptor/ligand system by ***interferon gamma*** and cyclosporin A was investigated .	target	0
273	10029626	3458;355	interferon gamma;CD95	In liver parenchymal cells , ***interferon gamma*** ***increased*** messenger RNA levels of the transmembrane ***CD95*** isoform and sensitivity of these cells toward CD95-mediated apoptosis .	positive	0
274	10030281	925;7040	CD8;TGF-beta1	***CD8*** cross-linking on BMC ***induced*** secretion of active transforming growth factor-beta1 ( ***TGF-beta1*** ) , suggesting a regulatory mechanism ( s ) operating via a CD8-mediated signaling pathway .	target	1
275	10030292	356;355	FasL;Fas	Finally , recombinant human FasL induced apoptosis in Fas expressing porcine EC cells , demonstrating that human ***FasL*** ***interacted*** with and activated ***Fas*** on porcine EC cells .	parallel	1
276	10030296	7035;2152	hTFPI;tissue factor	They are based on two naturally occurring soluble anticoagulant proteins , human ***tissue factor*** pathway ***inhibitor*** ( ***hTFPI*** ) and the leech protein hirudin , which act early and late in the clotting cascade , respectively .	negative	1
277	10030420	51497;3558	TH1;IL-2	RESULTS : The cellular immune response to recombinant adenovirus is ( 1 ) averted by T lymphocyte depletion , ( 2 ) marked by a ***TH1*** ***response*** with increased ***IL-2*** production , ( 3 ) directed against both the transgene product and viral proteins , and ( 4 ) associated with increased hepatocyte MHC Class I expression .	parallel	0
278	10030670	1869;1026	E2F1;p21	We have found that ***E2F1*** and E2F3 , transcription factors that activate genes required for cell cycle progression , are strong ***activators*** of the ***p21*** promoter .	positive	1
279	10030670	1871;1026	E2F3;p21	We have found that E2F1 and ***E2F3*** , transcription factors that activate genes required for cell cycle progression , are strong ***activators*** of the ***p21*** promoter .	positive	1
280	10030670	26959;1026	HBP1;p21	In contrast , ***HBP1*** ( HMG-box protein-1 ) , a novel retinoblastoma protein-binding protein , can ***repress*** the ***p21*** promoter and inhibit induction of p21 expression by E2F .	negative	1
281	10030670	26959;1026	HBP1;p21	Both E2Fs and ***HBP1*** ***regulate*** ***p21*** transcription through cis-acting elements located between nucleotides -119 to +16 of the p21 promoter and the DNA binding domains of each of these proteins are required for activity .	target	1
282	10030673	5594;3725	Erk2;AP-1	Expression of dominant negative ***Erk2*** ***inhibits*** ***AP-1*** transactivation and neoplastic transformation .	negative	1
283	10030838	3458;6348	IFN-gamma;MIP-1alpha	***IFN-gamma*** ***potentiates*** the release of TNF-alpha and ***MIP-1alpha*** by alveolar macrophages during allergic reactions .	positive	0
284	10030838	3458;7124	IFN-gamma;TNF-alpha	***IFN-gamma*** ***potentiates*** the release of ***TNF-alpha*** and MIP-1alpha by alveolar macrophages during allergic reactions .	positive	0
285	10030838	3497;6348	IgE;MIP-1alpha	Interestingly , IgE/anti-GeneGene 3 treatment did not stimulate the release of MIP-1alpha ( 15 + / - 5 pg/10 ( 6 ) cells ) , but IFN-gamma treatment alone and with IgE / ***anti-IgE*** significantly ***increased*** and potentiated ***MIP-1alpha*** release ( 98 + / - 40 pg/10 ( 6 ) cells ) by alveolar macrophages , respectively .	positive	0
286	10030839	7124;4586	Tumor necrosis factor-alpha;mucin	***Tumor necrosis factor-alpha*** ***stimulates*** ***mucin*** secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro .	positive	0
287	10030839	7124;4586	TNF-alpha;mucin	Collectively , the results suggest that ***TNF-alpha*** ***stimulates*** secretion of ***mucin*** by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG .	positive	0
288	10030841	3553;5156	IL-1beta;PDGF-Ralpha	Because ***IL-1beta*** ***upregulates*** both PGE2 production and ***PDGF-Ralpha*** expression , these data suggest that PGE2 functions in a negative feedback loop to limit expression of PDGF-Ralpha and suppress PDGF-stimulated myofibroblast proliferation .	positive	1
289	10030846	3596;7124	IL-13;TNF-alpha	Because activation of eosinophils has been regarded as a crucial event in the pathogenesis of asthmatic inflammation , we tested the hypothesis that IL-4 and ***IL-13*** could ***enhance*** the effects of ***TNF-alpha*** on eosinophil activation .	positive	0
290	10030846	3565;7124	IL-4;TNF-alpha	Because activation of eosinophils has been regarded as a crucial event in the pathogenesis of asthmatic inflammation , we tested the hypothesis that ***IL-4*** and IL-13 could ***enhance*** the effects of ***TNF-alpha*** on eosinophil activation .	positive	0
291	10036234	8676;8773	Syntaxin 11;SNAP-23	***Syntaxin 11*** is ***associated*** with ***SNAP-23*** on late endosomes and the trans-Golgi network .	parallel	0
292	10036235	382;5879	ARF6;Rac1	These observations suggest that ***ARF6*** , a non-Rho family GTPase , can , by itself , alter cortical actin and can ***influence*** the ability of ***Rac1*** to form lamellipodia , in part , by regulating its trafficking to the plasma membrane .	target	0
293	10036238	7432;1080	VIP;CFTR	***CFTR*** channel insertion to the apical surface in rat duodenal villus epithelial cells is ***upregulated*** by ***VIP*** in vivo .	positive	1
294	10036239	4771;7430	merlin;ezrin	Homotypic and heterotypic ***interaction*** of the neurofibromatosis 2 tumor suppressor protein ***merlin*** and the ERM protein ***ezrin*** .	parallel	1
295	10036239	7430;4771	ezrin;merlin	***ezrin*** was ***coimmunoprecipitated*** with ***merlin*** from lysates of human U251 glioma cells and from COS-1 cells transfected with cDNA encoding for merlin isoform I.	parallel	1
296	10036239	7430;4771	ezrin;merlin	The heterotypic ***binding*** of ***merlin*** and ***ezrin*** and the homotypic association of merlin involves interaction between the amino - and carboxy-termini .	parallel	1
297	10036244	8506;1500	p190;p120	We found that activation of v-Src induced ***association*** of tyrosine phosphorylated ***p190*** with ***p120*** ( RasGAP ) and stimulation of p120 ( RasGAP ) - associated RhoGAP activity , although p120 ( RasGAP ) itself was not a target for phosphorylation by v-Src in chicken embryo cells .	parallel	0
298	10036244	8506;1500	p190;p120	Furthermore , these effects were rapidly reversible since switching off v-Src led to dissociation of the ******p190/p120****** ( RasGAP ) ***complex*** , inactivation of p120 ( RasGAP ) - associated RhoGAP activity and re-induction of actin stress fibres .	parallel	1
299	10036280	4803;6336	nerve growth factor;SNS	TTX-R sodium currents and ***SNS*** mRNA expression have been shown to be ***modulated*** by ***nerve growth factor*** ( NGF ) in vitro and in vivo .	target	0
300	10036617	2;5327	alpha 2-macroglobulin;tPA	The present data also demonstrates that the ***activation*** of ***tPA*** by the ***alpha 2-macroglobulin*** fraction is due to the action of a bound proteinase distinct from hPK , indicating the presence of an additional tPA activator .	positive	1
301	10037006	3553;3569	IL-1beta;IL-6	Cytokines , of which TNF-alpha and ***IL-1beta*** produced by MM or accessory cells , were also able to ***stimulate*** ***IL-6*** production by fibroblasts and show additive effects .	positive	0
302	10037006	7124;3569	TNF-alpha;IL-6	Cytokines , of which ***TNF-alpha*** and IL-1beta produced by MM or accessory cells , were also able to ***stimulate*** ***IL-6*** production by fibroblasts and show additive effects .	positive	0
303	10037022	4233;3082	c-Met;hepatocyte growth factor	The role of ***hepatocyte growth factor*** and its ***receptor*** ***c-Met*** in multiple myeloma and other blood malignancies .	parallel	1
304	10037022	4233;3082	c-Met;hepatocyte growth factor	The cytokine ***hepatocyte growth factor*** ( HGF ) and its ***receptor*** ***c-Met*** are a ligand-receptor pair with important functions in a communicative interplay between HGF-producing , mesenchymal cells and c-Met-expressing target cells .	parallel	1
305	10037043	1437;6402	GM-CSF;CD62L	In vivo administration of G-CSF reduced the adherence capacity of CD34 + cells to normal BM stroma ; in vitro incubation with SCF or IL-3 enhanced the expression of CD49d on CD34 + cells , while ***GM-CSF*** ***reduced*** the expression of ***CD62L*** .	negative	1
306	10037138	10664;4609	CTCF;c-myc	Differential expression and phosphorylation of ***CTCF*** , a ***c-myc*** transcriptional ***regulator*** , during differentiation of human myeloid cells .	target	1
307	10037138	10664;4609	CTCF;c-myc	***CTCF*** is a transcriptional ***repressor*** of the ***c-myc*** gene .	negative	1
308	10037141	796;43	Calcitonin;acetylcholinesterase	***Calcitonin*** gene-related peptide ***decreases*** expression of ***acetylcholinesterase*** in mammalian myotubes .	negative	0
309	10037150	5894;5604	Raf-1;MEK1	In vitro , however , SB203580-stimulated ***Raf-1*** ***activates*** ***MEK1*** in a coupled assay .	positive	1
310	10037150	5594;5609	ERK;MEK	We conclude that activation of Raf-1 by SB203580 is not mediated by an inhibition of p38 MAPK , is Ras-independent , and is uncoupled from ******MEK/ERK****** ***signaling*** .	parallel	0
311	10037193	355;356	Fas;FasL	USA , 94 : 8144-8149 , 1997 ) that thymineless death in thymidylate synthase-deficient ( TS - ) colon carcinoma cells is mediated via ******Fas/FasL****** ***interactions*** after deoxythymidine ( dThd ) deprivation , and that Fas-dependent sensitivity of human colon carcinoma cell lines may be dependent upon the level of Fas expressed .	parallel	1
312	10037193	355;356	Fas;FasL	The cytotoxic activity of FUra/LV was inhibited by dThd in HT29 cells and also , in part , by NOK-1 + NOK-2 MoAbs that prevent ******Fas/FasL****** ***interactions*** .	parallel	1
313	10037278	7157;596	p53;bcl-2	Since ***bcl-2*** is negatively ***regulated*** by ***p53*** , it could be presumed that the p53 detected in the tumour cells may be non-functional or inactive possibly because of interaction with proteins such as E6 or mdm-2 .	negative	1
314	10037443	2100;2099	ER-beta;ER-alpha	***Binding*** of ***ER-alpha*** and ***ER-beta*** occurred at similar DNA concentrations for some EREs , but different DNA concentrations were required to form complexes of the two receptors with other elements .	parallel	1
315	10037444	2159;5502	factor Xa;inhibitor-1	When added to confluent HUVEC , ***factor Xa*** ***induced*** the expression of tissue factor and the release of tissue-type plasminogen activator and plasminogen activator ***inhibitor-1*** without affecting urokinase expression .	target	1
316	10037444	2159;2152	factor Xa;tissue factor	When added to confluent HUVEC , ***factor Xa*** ***induced*** the expression of ***tissue factor*** and the release of tissue-type plasminogen activator and plasminogen activator inhibitor-1 without affecting urokinase expression .	target	1
317	10037468	2956;4436	MSH6;MSH2	The MutS homologues ***MSH2*** and ***MSH6*** form a heterodimeric protein ***complex*** that is involved in the recognition of base/base mismatches and insertion/deletion loops , as well as some other types of DNA damage .	parallel	1
318	10037506	2743;10243	glycine receptor beta-subunit;gephyrin	Hydrophobic interactions mediate ***binding*** of the ***glycine receptor beta-subunit*** to ***gephyrin*** .	parallel	1
319	10037681	5578;5337	PKC-alpha;PLD1	Successful ***interaction*** of ARF and ***PKC-alpha*** with ***PLD1*** was not achieved , but a C-terminal fragment of human PLD1 ( denoted " D4 " ) interacted with the active mutant of RhoA , RhoAVal-14 .	parallel	1
320	10037682	4001;836	lamin B1;caspase-3	Lithium pretreatment blocks glutamate-induced cytochrome c release and cleavage of ***lamin B1*** , a nuclear ***substrate*** for ***caspase-3*** .	parallel	1
321	10037686	8784;7185	AITR;TNF receptor-associated factor 1	***AITR*** ***associates*** with TRAF1 ( ***TNF receptor-associated factor 1*** ) , TRAF2 , and TRAF3 , and induces nuclear factor ( NF ) - kappaB activation via TRAF2 .	parallel	0
322	10037686	8784;7186	AITR;TRAF2	***AITR*** ***associates*** with TRAF1 ( TNF receptor-associated factor 1 ) , ***TRAF2*** , and TRAF3 , and induces nuclear factor ( NF ) - kappaB activation via TRAF2 .	parallel	0
323	10037686	8784;7187	AITR;TRAF3	***AITR*** ***associates*** with TRAF1 ( TNF receptor-associated factor 1 ) , TRAF2 , and ***TRAF3*** , and induces nuclear factor ( NF ) - kappaB activation via TRAF2 .	parallel	0
324	10037694	3667;3643	IRS-1;insulin receptor	Phosphotyrosine binding ( PTB ) domains of the adaptor protein Shc and ***insulin receptor*** ***substrate*** ( ***IRS-1*** ) interact with a distinct set of activated and tyrosine-phosphorylated cytokine and growth factor receptors and play important roles in mediating mitogenic signal transduction .	parallel	1
325	10037706	5034;811	PDI;calreticulin	Using this technique we demonstrate that ***PDI*** ***interacts*** with ***calreticulin*** at low Ca2 + concentration ( below 100 microM ) , whereas the protein complex dissociates at > 400 microM Ca2 + .	parallel	1
326	10037706	2923;811	ERp57;calreticulin	***ERp57*** also ***interacts*** with ***calreticulin*** through the N-domain of the protein .	parallel	1
327	10037723	4292;5395	hMLH1;hPMS2	These data confirm that functional deficiencies in the ***interaction*** of ***hMLH1*** with ***hPMS2*** are associated with HNPCC as well as suggest that other unknown functional alteration of the human MutL homologues may lead to tumorigenesis in HNPCC kindreds .	parallel	1
328	10037736	9603;7975	Nrf3;MafK	In vitro and in vivo analyses showed that ***Nrf3*** can ***heterodimerize*** with ***MafK*** and that this complex binds to the MARE in the chicken beta-globin enhancer and can activate transcription .	parallel	1
329	10037739	596;7157	Bcl-2;p53	***Inhibition*** of ***p53*** transcriptional activity by ***Bcl-2*** requires its membrane-anchoring domain .	negative	1
330	10037743	960;3082	CD44;hepatocyte growth factor	In the present study , we have explored the possibility of a physical and functional ***interaction*** between ***CD44*** and ***hepatocyte growth factor/scatter factor*** ( HGF/SF ) , the ligand of the receptor tyrosine kinase c-Met .	parallel	1
331	10037743	3082;960	scatter factor;CD44	In the present study , we have explored the possibility of a physical and functional ***interaction*** between ***CD44*** and ***hepatocyte growth factor/scatter factor*** ( HGF/SF ) , the ligand of the receptor tyrosine kinase c-Met .	parallel	1
332	10037743	3082;3082	scatter factor;hepatocyte growth factor	In the present study , we have explored the possibility of a physical and functional ***interaction*** between CD44 and ******hepatocyte growth factor/scatter factor****** ( HGF/SF ) , the ligand of the receptor tyrosine kinase c-Met .	parallel	1
333	10037743	3082;4233	HGF;c-Met	We show that , as compared with CD44s , CD44v3 promotes : ( i ) ***HGF/SF-induced*** ***phosphorylation*** of ***c-Met*** , ( ii ) phosphorylation of several downstream proteins , and ( iii ) activation of the MAP kinases ERK1 and -2 .	target	1
334	10037745	6493;405	Sim;Arnt	HIF-1alpha ( hypoxia-inducible factor 1alpha ) is a basic-helix-loop-helix PAS ( ***Per/Arnt/Sim*** ) transcription factor that , under hypoxic conditions , ***dimerizes*** with a partner factor , the basic-helix-loop-helix / PAS protein ***Arnt*** , to recognize hypoxia-responsive elements of target genes .	parallel	1
335	10037749	4609;5604	c-Myc;mitogen-activated protein kinase kinase-1	Expression of ***c-Myc*** in response to colony-stimulating factor-1 ***requires*** ***mitogen-activated protein kinase kinase-1*** .	target	0
336	10037749	1436;4609	CSF-1R;c-Myc	Therefore , MEK1 participates in an obligate signaling pathway ***linking*** ***CSF-1R*** to ***c-Myc*** expression , but other signals from CSF-1R must cooperate with the MEK/ERK pathway to induce c-Myc expression and S phase entry in response to CSF-1 stimulation .	parallel	0
337	10037764	10499;5469	TIF 2;TRAP220	In light of the functional differences identified between p160 and TRAP coactivator complexes in NR activation , we have attempted to compare ***interaction*** and functional characteristics of ***TIF 2*** and ***TRAP220*** .	parallel	1
338	10037767	6775;3659	signal transducer and activator of transcription-4;IRF-1	We demonstrate that IL-12-induced up-regulation of ***IRF-1*** is ***mediated*** by ***signal transducer and activator of transcription-4*** , which binds to the interferon ( IFN ) - gamma-activated sequence present in the promoter of the IRF-1 gene .	target	0
339	10037770	5467;1387	PPARdelta;CREB-binding protein	Both PPARgamma and ***PPARdelta*** directly ***interacted*** with a nuclear receptor co-activator ( ***CREB-binding protein*** ) in an agonist-dependent manner .	parallel	1
340	10037770	5468;1387	PPARgamma;CREB-binding protein	Both ***PPARgamma*** and PPARdelta directly ***interacted*** with a nuclear receptor co-activator ( ***CREB-binding protein*** ) in an agonist-dependent manner .	parallel	1
341	10037772	940;2185	CD28;Pyk2	***CD28*** ligation ***induces*** tyrosine phosphorylation of ***Pyk2*** but not Fak in Jurkat T cells .	target	1
342	10037772	5829;5747	Paxillin;Fak	***Paxillin*** , a ***substrate*** for Pyk2 and ***Fak*** , was not tyrosine-phosphorylated after CD28 ligation .	parallel	1
343	10037772	5829;2185	Paxillin;Pyk2	***Paxillin*** , a ***substrate*** for ***Pyk2*** and Fak , was not tyrosine-phosphorylated after CD28 ligation .	parallel	1
344	10037772	940;2185	CD28;Pyk2	***CD28-induced*** tyrosine ***phosphorylation*** of ***Pyk2*** was markedly reduced in the absence of external Ca2 + .	target	1
345	10037774	5008;3949	oncostatin M;LDLR	***Induction*** of low density lipoprotein receptor ( ***LDLR*** ) transcription by ***oncostatin M*** is mediated by the extracellular signal-regulated kinase signaling pathway and the repeat 3 element of the LDLR promoter .	target	1
346	10037774	5008;3949	oncostatin M;LDLR	***oncostatin M*** ( OM ) ***activates*** the transcription of the human low density lipoprotein receptor ( ***LDLR*** ) in HepG2 cells through a sterol-independent mechanism .	positive	1
347	10037782	4792;4790	IkappaBalpha;NF-kappaB	Here , we report that IkappaBalpha , when not bound to NF-kappaB , is constitutively transported to the nucleus , and we confirm that the ***interaction*** of ***IkappaBalpha*** with ***NF-kappaB*** retains IkappaBalpha in the cytoplasm .	parallel	1
348	10037790	999;1499	E-cadherin;beta-catenin	Coupling assembly of the ******E-cadherin/beta-catenin****** ***complex*** to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells .	parallel	1
349	10037790	1499;999	beta-catenin;E-cadherin	Thus , ***beta-catenin*** binding to the whole cytoplasmic domain of E-cadherin ***correlates*** with efficient and targeted delivery of ***E-cadherin*** to the lateral plasma membrane .	parallel	0
350	10037790	1499;999	beta-catenin;E-cadherin	In this capacity , we suggest that ***beta-catenin*** acts as a chauffeur , to ***facilitate*** transport of ***E-cadherin*** out of the ER and the plasma membrane .	positive	0
351	10037796	6352;1234	RANTES;CCR5	Using CCR5-transfected HEK-293 cells , we show that both the ***CCR5*** ***ligand*** , ***RANTES*** , as well as its derivative , aminooxypentane ( AOP ) - RANTES , trigger immediate responses such as Ca2 + influx , receptor dimerization , tyrosine phosphorylation , and Galphai as well as JAK/STAT association to the receptor .	parallel	1
352	10037796	5747;7852	FAK;chemokine receptor	In contrast to RANTES , ( AOP ) - RANTES is unable to trigger late responses , as measured by the ***association*** of focal adhesion kinase ( ***FAK*** ) to the ***chemokine receptor*** complex , impaired cell polarization required for migration , or chemotaxis .	parallel	0
353	10037797	961;3685	CD47;vitronectin receptor	***CD47*** , a member of the multispan transmembrane receptor family , physically and functionally ***associates*** with ***vitronectin receptor*** ( VnR ) .	parallel	0
354	10047452	5329;5328	UPAR;UPA	Finally , the expression of both urokinase plasminogen activator ( ***UPA*** ) and its ***receptor*** ( ***UPAR*** ) were induced after TPA treatment by 8 - and 7-fold , respectively .	parallel	1
355	10047779	7518;3981	XRCC4;DNA ligase IV	Recent studies have shown that ***XRCC4*** ***interacts*** with and enhances the activity of ***DNA ligase IV*** in vitro .	parallel	1
356	10047779	7518;3981	XRCC4;DNA ligase IV	These data strongly suggest that an important function of ***XRCC4*** is to ***stabilize*** the ***DNA ligase IV*** protein .	positive	0
357	10048020	100;2648	ADA;GCN5	We found that gan1 is identical to ADA1 , which encodes a component of the ******ADA/GCN5****** co-activator ***complex*** .	parallel	1
358	10048132	1392;5443	CRH;ACTH	Support for the TCDD-AhR-mediated increases in ACTH concentrations is provided by the following observations : ( 1 ) ANF inhibited both the 1.3 - to 2-fold TCDD-induced increase in basal medium and intracellular ACTH concentrations and the 30 % TCDD-induced decrease in medium ACTH levels and the 1.2-fold increase in intracellular ACTH levels in corticotropin-releasing hormone ( CRH ) - stimulated cells , ( 2 ) BNF increased basal medium ( 1.7-fold ) and intracellular ( 1.3-fold ) ACTH concentrations , ( 3 ) BNF + TCDD demonstrated additivity by increasing basal medium ( 2.4-fold ) and intracellular ( 1.7-fold ) ACTH concentrations , ( 4 ) PCB increased basal medium ( 1.8 - to 2.1-fold ) and intracellular ( 1.3 - to 1.8-fold ) ACTH concentrations and inhibited medium ACTH secretion in CRH stimulated cells by 24-43 % , and ( 5 ) HCB did not effect basal or ***CRH*** ***stimulated*** medium and intracellular ***ACTH*** concentrations .	positive	0
359	10048154	196;405	AhR;ARNT	In human palates , ***AhR*** expression ***correlated*** with ***ARNT*** and CYP1A1 mRNA expression .	parallel	0
360	10048154	196;1543	AhR;CYP1A1	In human palates , ***AhR*** expression ***correlated*** with ARNT and ***CYP1A1*** mRNA expression .	parallel	0
361	10048431	3815;4254	c-kit;SCF	The receptor for FL belongs to the class III family of receptor tyrosine kinases which also includes ***c-kit*** , the ***receptor*** for stem cell factor ( ***SCF*** ) .	parallel	1
362	10048449	5604;23552	MKK1;p42	In contrast , constitutive active ***MKK1*** , the classical ***p42/44*** MAPK ***activator*** , increased cyclin D1 promoter activity and level of protein .	positive	1
363	10048449	5604;595	MKK1;cyclin D1	In contrast , constitutive active ***MKK1*** , the classical p42/44 MAPK activator , ***increased*** ***cyclin D1*** promoter activity and level of protein .	positive	0
364	10048580	5747;1445	pp125FAK;CSK	De novo expression of ***pp125FAK*** in human macrophages ***regulates*** ***CSK*** distribution and MAP kinase activation but does not affect focal contact structure .	target	1
365	10048580	5747;1445	FAK;CSK	***FAK*** ***associates*** with ***CSK*** 48 h after infection and recruits it to focal contacts .	parallel	0
366	10048979	7040;4091	TGF-beta1;Smad6	***TGF-beta1*** ***induced*** endogenous PAI-1 protein synthesis , Smad binding element / ( CAGA ) 12-luciferase-reporter activity , as well as mRNA expression of ***Smad6*** and Smad7 in all gliomas .	target	1
367	10048979	7040;4092	TGF-beta1;Smad7	***TGF-beta1*** ***induced*** endogenous PAI-1 protein synthesis , Smad binding element / ( CAGA ) 12-luciferase-reporter activity , as well as mRNA expression of Smad6 and ***Smad7*** in all gliomas .	target	1
368	10048979	7040;5054	TGF-beta1;PAI-1	***TGF-beta1*** ***induced*** endogenous ***PAI-1*** protein synthesis , Smad binding element / ( CAGA ) 12-luciferase-reporter activity , as well as mRNA expression of Smad6 and Smad7 in all gliomas .	target	1
369	10048979	7040;7046	TGF-beta1;TbetaR-I	Interestingly , ***TGF-beta1*** differentially ***stimulated*** or inhibited the expression of ***TbetaR-I*** and TbetaR-II mRNA in the gliomas .	positive	0
370	10048979	7040;7048	TGF-beta1;TbetaR-II	Interestingly , ***TGF-beta1*** differentially ***stimulated*** or inhibited the expression of TbetaR-I and ***TbetaR-II*** mRNA in the gliomas .	positive	0
371	10048979	7040;4087	TGF-beta1;Smad2	In all gliomas , ***TGF-beta1*** ***induced*** phosphorylation of ***Smad2*** .	target	1
372	10049059	356;2187	Fas ligand;FAB	***Fas ligand*** expression in the bone marrow in myelodysplastic syndromes ***correlates*** with ***FAB*** subtype and anemia , and predicts survival .	parallel	0
373	10049060	3562;1440	IL-3;G-CSF	We report that ***IL-3*** ***inhibited*** the ability of ***G-CSF*** to induce Stat3 DNA binding .	negative	1
374	10049060	1440;6774	G-CSF;Stat3	Moreover , we find that ***G-CSF*** ***activation*** of ***Stat3*** binding to DNA is biphasic , peaking at 15-30 min and again at 6-8 h ; both peaks are inhibited by IL-3 .	positive	1
375	10049302	9622;83716	kallikrein;trypsin inhibitor	In the second group , represented by the ***complex*** of ***kallikrein*** and pancreatic ***trypsin inhibitor*** , the overall stability results from the rather nonspecific electrostatic attraction , whereas the affinity toward the binding region is determined by desolvation interactions .	parallel	1
376	10049357	9612;9611	SMRT;N-CoR	The ******N-CoR/SMRT****** ***complex*** containing mSin3 and histone deacetylase ( HDAC ) mediates transcriptional repression by nuclear hormone receptors and Mad .	parallel	1
377	10049387	55651;54433	NolA2;NolA1	The expression of both ***NolA2*** and NolA3 ***requires*** the presence of ***NolA1*** .	target	0
378	10049387	55505;54433	NolA3;NolA1	The expression of both NolA2 and ***NolA3*** ***requires*** the presence of ***NolA1*** .	target	0
379	10049518	3569;973	IL-6;IgA	More importantly , culture supernatants from LPS stimulated IEC-6 cells contained enhanced levels of ***IL-6*** which ***enhanced*** both IgG and ***IgA*** production and partially overcame the suppressive effect of TGF-beta on IgM secretion .	positive	0
380	10049521	3552;3569	IL-1alpha;IL-6	***IL-1alpha*** ***upregulates*** ***IL-6*** production ; therefore , the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin-embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens , a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity ( P = 0.32 by Fisher 's exact test ) .	positive	1
381	10049569	8851;1020	p35;cdk5	Thus , ******cdk5/p35****** ***complexes*** function in aspects of neural differentiation and patterning in the early embryo and particularly in formation of the eye .	parallel	1
382	10049647	3458;6590	Interferon-gamma;SLPI	***Interferon-gamma*** ( IFN-gamma ) , which corrects the defective LPS response in Lps ( d ) macrophages , ***suppressed*** the LPS-induced expression of ***SLPI*** and restored LPS response to SLPI-overexpressing macrophages .	negative	1
383	10049647	3603;6590	interleukin-10 and -6;SLPI	The expression of ***SLPI*** was strongly ***enhanced*** by ***interleukin-10 and -6*** .	positive	0
384	10049690	283120;3481	H19;IGF2	The ***H19*** gene is closely ***linked*** to the human IGF-II gene ( ***IGF2*** ) on chromosome 11p15 .5 and these genes are reciprocally imprinted in most fetal tissues .	parallel	0
385	10049699	3586;6348	interleukin-10;macrophage inflammatory protein-1 alpha	***Regulation*** of ***macrophage inflammatory protein-1 alpha*** expression and function by endogenous ***interleukin-10*** in a model of acute inflammation .	target	1
386	10049709	598;581	Bcl-XL;Bax	Furthermore , several binding assays demonstrated that ***Bcl-XL*** , an anti-apoptotic member of the Bcl-2 family , can ***bind*** to the oligomeric form of ***Bax*** without requiring Bax to dissociate to monomers .	parallel	1
387	10049710	8773;6616	SNAP-23;SNAP	We have reexamined the intracellular localization of the ubiquitously expressed target membrane ***SNAP*** ***receptor*** ( t-SNARE ) , ***SNAP-23*** .	parallel	1
388	10049733	3458;6357	IFN-gamma;MCP-4	Like MCP-3 , ***MCP-4*** mRNA expression in dermal fibroblasts is ***upregulated*** by TNF-alpha , IL-1alpha , ***IFN-gamma*** or IL-4 and differs from RANTES and eotaxin mRNA expression in its response to IFN-gamma and/or IL-4 .	positive	1
389	10049733	3552;6357	IL-1alpha;MCP-4	Like MCP-3 , ***MCP-4*** mRNA expression in dermal fibroblasts is ***upregulated*** by TNF-alpha , ***IL-1alpha*** , IFN-gamma or IL-4 and differs from RANTES and eotaxin mRNA expression in its response to IFN-gamma and/or IL-4 .	positive	1
390	10049733	3565;6357	IL-4;MCP-4	Like MCP-3 , ***MCP-4*** mRNA expression in dermal fibroblasts is ***upregulated*** by TNF-alpha , IL-1alpha , IFN-gamma or ***IL-4*** and differs from RANTES and eotaxin mRNA expression in its response to IFN-gamma and/or IL-4 .	positive	1
391	10049733	7124;6357	TNF-alpha;MCP-4	Like MCP-3 , ***MCP-4*** mRNA expression in dermal fibroblasts is ***upregulated*** by ***TNF-alpha*** , IL-1alpha , IFN-gamma or IL-4 and differs from RANTES and eotaxin mRNA expression in its response to IFN-gamma and/or IL-4 .	positive	1
392	10049734	836;142	CPP32;PARP	Since ***PARP*** is ***cleaved*** by ***CPP32*** ( caspase-3 ) , we next determined if H2O2 was capable of effecting changes in CPP32 activity .	target	1
393	10049757	6732;3930	SRPK1;LBR	Using synthetic peptides representing different regions of LBR and recombinant proteins produced in bacteria we now demonstrate that ***SRPK1*** ***modifies*** ***LBR*** with similar kinetics and on the same sites as the LBR kinase , that are also phosphorylated in vivo .	target	0
394	10049759	3479;3667	IGF-I;IRS-1	***IGF-I*** ***regulates*** ***IRS-1*** expression in 3T3-L1 adipocytes .	target	1
395	10049759	3479;3667	IGF-I;IRS-1	Actinomycin D and cycloheximide blocked the IGF-I effect , but not the insulin effect , suggesting that ***IGF-I*** ***stimulated*** the synthesis of ***IRS-1*** .	positive	0
396	10049762	1020;4137	Cdk5;tau	Active ***Cdk5*** is thought to be involved in the in vivo ***phosphorylation*** of the neurofilament proteins and ***tau*** which are hyperphosphorylated in neurodegenerative diseases .	target	1
397	10049762	6164;1019	L34;Cdk4	***L34*** also ***interacts*** with ***Cdk4*** and , in parallel , inhibits the Cdk4/cyclin D1 activity .	parallel	1
398	10049767	9546;351	X11L2;beta-amyloid precursor protein	***X11L2*** , a new member of the X11 protein family , ***interacts*** with Alzheimer 's ***beta-amyloid precursor protein*** .	parallel	1
399	10049778	581;834	Bax;Caspase-1	***Caspase-1*** was ***activated*** only by ***Bax*** significantly when coexpressed with mutated p53 but not with wt p53 .	positive	1
400	10049787	5741;4254	PTH;SCF	The major osteoblastic ***SCF*** mRNA , approximately 5 kB , was ***augmented*** by ***PTH*** .	positive	0
401	10049825	100188830;2033	Ad12;p300	We analyzed the ***interaction*** of the ***Ad12*** E1A 235R protein with ***p300*** and CBP .	parallel	1
402	10049915	11200;10926	RAD53;DBF4	***RAD53*** ***regulates*** ***DBF4*** independently of checkpoint function in Saccharomyces cerevisiae .	target	1
403	10049915	11200;10926	RAD53;DBF4	Furthermore , the steady-state level of DBF4 message and Dbf4p protein is reduced in several RAD53 mutant strains , indicating that ***RAD53*** positively ***regulates*** ***DBF4*** .	positive	1
404	10049941	356;5551	FasL;perforin	The contribution of specific cytotoxic T lymphocytes ( CTLs ) to the CHS reaction was examined both in vivo and in vitro , using mice deficient in ***perforin*** and/or Fas/Fas ***ligand*** ( ***FasL*** ) pathways involved in cytotoxicity .	parallel	1
405	10049948	959;958	CD40 ligand;CD40	Expression of stromelysin-3 in atherosclerotic lesions : regulation via ******CD40-CD40 ligand****** ***signaling*** in vitro and in vivo .	parallel	0
406	10049948	959;958	CD40L;CD40	These observations establish the expression of the unusual matrix metalloproteinase stromelysin-3 in human atherosclerotic lesions and implicate ******CD40-CD40L****** ***signaling*** in its regulation , thus providing a possible new pathway that triggers complications within atherosclerotic lesions .	parallel	0
407	10050087	3487;3479	IGFBP-1 and 4;IGF-1	Initial glomerular hypertrophy of diabetic nephropathy is a related ***IGF-1*** action , which may be ***modulated*** by ***IGFBP-1 and 4*** .	target	0
408	10050668	3383;3689	ICAM-1;Mac-1	Taken together , our results suggest that eotaxin-induced eosinophil transendothelial migration in vivo and in vitro relies on ******Mac-1/ICAM-1****** and VLA-4NCAM-1 ***interactions*** , the latter ones becoming more relevant at later time points of the eotaxin-induced recruitment process .	parallel	1
409	10050675	958;959	CD40;CD154	******CD154-CD40****** ***interactions*** are of central importance for the induction of antibody responses to T-dependent antigens .	parallel	1
410	10050701	7852;6387	CXCR4;SDF-1	***CXCR4*** is also a natural ***receptor*** for the chemokine ***SDF-1*** .	parallel	1
411	10050758	1173;10618	mu2;TGN38	Phosphorylation of mu2 was shown to have no significant effect on the in vitro ***interaction*** of ***mu2*** with the cytosolic domain of ***TGN38*** , indicating that reversible phosphorylation of mu2 does not play a role in regulating its direct interaction with tyrosine based internalisation motifs .	parallel	1
412	10050772	6750;2641	Somatostatin;glucagon	***Somatostatin*** ***inhibits*** ***glucagon-secretion*** from pancreatic alpha cells but its underlying mechanism is unknown .	negative	1
413	10050876	1326;5604	Cot;MEK-1	Expression of oncogenic Cot in 293 , NIH3T3 and PC12 cells leads to in vivo phosphorylation of endogenous c-Jun and Erk-1/2 suggesting that the serine/threonine kinase ***Cot*** functions beside c-Raf-1 and Mos as a direct ***activator*** of ***MEK-1*** .	positive	1
414	10050884	4613;581	MycN;Bax	***MycN*** overexpression and cytotoxic drugs also synergized to ***induce*** p53 and ***Bax*** protein expression , while Bcl-2 and Bcl-X ( L ) protein levels remained unchanged .	target	1
415	10050884	4613;7157	MycN;p53	***MycN*** overexpression and cytotoxic drugs also synergized to ***induce*** ***p53*** and Bax protein expression , while Bcl-2 and Bcl-X ( L ) protein levels remained unchanged .	target	1
416	10050886	1387;6688	CBP;PU.1	Physical and functional ***interactions*** between the transcription factor ***PU.1*** and the coactivator ***CBP*** .	parallel	1
417	10050886	1387;6688	CBP;PU.1	CBP potentiated PU.1-mediated transcription of the reporter gene driven by the multimerized PU.1-binding sites , suggesting that ***CBP*** functions as a ***coactivator*** for ***PU.1*** .	positive	1
418	10051099	983;891	Cdc2;cyclin B1	HSP70-2 is required for ***Cdc2*** to form a ***heterodimer*** with ***cyclin B1*** , suggesting that it is a chaperone necessary for the progression of meiosis in the germ cells of male mice .	parallel	1
419	10051290	4018;4318	lipoprotein;matrix metalloproteinase-9	Oxidized low-density ***lipoprotein*** ***regulates*** ***matrix metalloproteinase-9*** and its tissue inhibitor in human monocyte-derived macrophages .	target	1
420	10051406	3667;3643	IRS-1;insulin receptor	The GRB2/Sos complex can connect with ***insulin receptor*** ***substrate*** 1 ( ***IRS-1*** ) , which is one of the primary targets of the insulin and insulin-like growth factor receptors .	parallel	1
421	10051439	6416;5599	MKK4;JNK	In addition , HA-tagged forms of the dual-specificity mitogen-activated protein kinase kinases ( MKKs ) , ***MKK4*** and MKK7 , which are specific ***activators*** of the ***JNK*** enzymes , were similarly expressed .	positive	1
422	10051439	5609;5599	MKK7;JNK	In addition , HA-tagged forms of the dual-specificity mitogen-activated protein kinase kinases ( MKKs ) , MKK4 and ***MKK7*** , which are specific ***activators*** of the ***JNK*** enzymes , were similarly expressed .	positive	1
423	10051443	8773;6810	SNAP-23;syntaxin 4	Co-immunoprecipitation of syntaxin 4 and SNAP-23 shows association of these two proteins in rat adipose cell plasma membranes , and insulin stimulation does not alter the ******SNAP-23/syntaxin 4****** ***complex*** .	parallel	1
424	10051443	8773;6810	SNAP-23;syntaxin 4	These data demonstrate that rat ***SNAP-23*** ***associates*** with ***syntaxin 4*** before insulin stimulation and is present in the SNARE complexes known to mediate the translocation of GLUT4 from intracellular vesicles to the plasma membrane of rat adipose cells .	parallel	0
425	10051448	4586;4843	mucin;NOS2	Taken together , these observations indicate ( 1 ) that ITF-binding molecules that are up-regulated by mucin exist on the intestinal epithelial surface , and ( 2 ) that ITF modulates epithelial NO production via the ***NOS2*** pathway , which is ***enhanced*** by ***mucin*** .	positive	0
426	10051455	7020;3481	AP-2;IGF-II	From these results we conclude that ***AP-2*** is an important ***regulator*** in vivo and in vitro of ***IGF-II*** P3 activity .	target	1
427	10051478	3383;3558	ICAM-1;interleukin-2	***Anti-ICAM-1*** treatment also ***decreased*** both the percentage of T cells and the production of ***interleukin-2*** ( IL-2 ) and IL-12 in the liver ( P < .01 ) , but had no effect on IL-4 , IL-10 , and interferon gamma .	negative	0
428	10051489	2908;3725	Glucocorticoid receptor;c-Jun	***Glucocorticoid receptor*** ***down-regulates*** ***c-Jun*** amino terminal kinases induced by tumor necrosis factor alpha in fetal rat hepatocyte primary cultures .	negative	1
429	10051543	7124;4790	tumor necrosis factor (TNF)-alpha;NF-kappaB	We tested the hypothesis that activation of protein kinase C ( PKC ) and generation of oxidants are critical sequential signals mediating ***tumor necrosis factor (TNF)-alpha-induced*** ***activation*** of nuclear factor-kappaB ( ***NF-kappaB*** ) and transcription of the intercellular adhesion molecule ( ICAM ) -1 gene .	positive	1
430	10051543	7124;4790	TNF-alpha;NF-kappaB	However , both PKC activation and oxidant generation were necessary for ICAM-1 mRNA expression because the pretreatment of HPAE cells with either calphostin C or N-acetylcysteine inhibited the ***TNF-alpha-induced*** ***activation*** of ***NF-kappaB*** and prevented the activation of ICAM-1 promoter .	positive	1
431	10051583	6256;5914	retinoid X receptor alpha;retinoic acid receptor alpha	Ligand-dependent activation of transcription in vitro by ******retinoic acid receptor alpha/retinoid X receptor alpha****** ***heterodimers*** that mimics transactivation by retinoids in vivo .	parallel	1
432	10051602	2288;5264	FKBP52;PAHX	Whereas the binding of calcineurin to FKBP12 is potentiated by FK506 , the specific ***association*** of ***PAHX*** and ***FKBP52*** is maintained in the presence of FK506 .	parallel	0
433	10051628	834;3458	caspase 1;IFN-gamma	In PBMCs , mature but not precursor IL-18 induces IFN-gamma ; in whole human blood stimulated with endotoxin , inhibition of ***caspase 1*** ***reduces*** ***IFN-gamma*** production by an IL-1beta-independent mechanism .	positive	1
434	10051665	627;2534	BDNF;Fyn	In vitro kinase assay revealed that ***BDNF*** can indeed ***activate*** the ***Fyn*** kinase : It enhanced tyrosine phosphorylation of Fyn as well as that of enolase supplemented exogenously .	positive	1
435	10051672	6000;10681	RGS7;Gbeta5	The specific ******Gbeta5-RGS7****** ***interaction*** is determined by a distinct domain in RGS that has a striking homology to Ggamma subunits .	parallel	1
436	10051672	10681;6000	Gbeta5;RGS7	Deletion of this domain prevents the ******RGS7-Gbeta5****** ***binding*** , although the interaction with Galpha is retained .	parallel	1
437	10051672	6000;8802	RGS7;Galpha	The interaction of Gbeta5 with RGS7 blocked the ***binding*** of ***RGS7*** to the ***Galpha*** subunit Galphao , indicating that Gbeta5 is a specific RGS inhibitor .	parallel	1
438	10051672	10681;6000	Gbeta5;RGS7	The ***interaction*** of ***Gbeta5*** with ***RGS7*** blocked the binding of RGS7 to the Galpha subunit Galphao , indicating that Gbeta5 is a specific RGS inhibitor .	parallel	1
439	10051672	10681;6000	Gbeta5;RGS7	The interaction of ***Gbeta5*** with RGS7 ***blocked*** the binding of ***RGS7*** to the Galpha subunit Galphao , indicating that Gbeta5 is a specific RGS inhibitor .	negative	0
440	10051679	1081;5047	hCG;glycodelin	Synthesis of the glandular secretory protein ***glycodelin*** , as assessed by Western blot analysis , was markedly ***up-regulated*** by ***hCG*** , and this increase was confirmed by immunocytochemistry , Northern blot analysis , and reverse transcriptase-PCR .	positive	1
441	10052459	5111;10036	PCNA;p150	***PCNA*** ***binds*** directly to ***p150*** , the largest subunit of CAF-1 , and the two proteins colocalize at sites of DNA replication in cells .	parallel	1
442	10052460	5087;3211	Pbx1;HoxB1	Structure of a ******HoxB1-Pbx1****** ***heterodimer*** bound to DNA : role of the hexapeptide and a fourth homeodomain helix in complex formation .	parallel	1
443	10052460	5087;3211	Pbx1;HoxB1	We report here the 2.35 A structure of a ternary complex containing a human ******HoxB1-Pbx1****** ***heterodimer*** bound to DNA .	parallel	1
444	10052685	2572;1493	GAD65;CTLA-4	In 84 patients , we also investigated ***associations*** between this ***CTLA-4*** gene polymorphism and ***GAD65*** antibody positivity .	parallel	0
445	10052934	7276;5950	TTR;RBP	We report here the crystallographic structure at 3.2 A of the protein-protein ***complex*** of human ***RBP*** and ***TTR*** .	parallel	1
446	100578	7200;5443	thyrotropin releasing hormone;alpha-melanocyte stimulating hormone	Demonstration of a temperature-dependent ***association*** of ***thyrotropin releasing hormone*** , ***alpha-melanocyte stimulating hormone*** , and luteinizing hormone releasing hormone with subneuronal particles in hypothalamic synaptosomes .	parallel	0
447	10063314	1029;1019	p16;cdk4	RESULTS : The newly-expressed ***p16*** formed a ***complex*** with ***cdk4*** , and phosphorylated pRB was decreased , although cyclin D1 and pRB : cyclin D1 complex were unchanged .	parallel	1
448	10063359	4233;3082	c-Met;hepatocyte growth factor	The clinical importance of the expression of ***c-Met*** protein , the ***receptor*** of ***hepatocyte growth factor/scatter factor*** , was evaluated in neuroepithelial tissue tumors .	parallel	1
449	10063405	3383;3684	ICAM-1;CD11b	Soluble ***ICAM-1*** ***decreased*** ***CD11b*** expression and adhesion in neutrophils exposed to reperfusion plasma only ( CD11b expression fell from 15.9 to 3.4 mcf , p < 0.01 Mann-Whitney U-test and adhesion fell to 11.6 % cells adhered , p < 0.01 ) .	negative	0
450	10063910	7124;4790	TNF-alpha;NF-kappaB	***TNF-alpha-induced*** ***activation*** of ***NF-kappaB*** activity was suppressed by NAC , and H2O2 caused significant activation of NF-kappaB .	positive	1
451	10064053	356;355	FasL;Fas	We show that an influenza hemagglutinin-specific CD4 + murine T cell hybridoma ( IP-12-7 ) enters the apoptotic suicide program via the ***Fas*** ***ligand*** ( ***FasL*** ) / Fas-mediated pathway upon T cell receptor ( TCR ) stimulation .	parallel	1
452	10064061	355;356	Fas;Fas ligand	Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice : no role of ******Fas-Fas ligand****** ***interaction*** in autoimmune diabetes .	parallel	1
453	10064070	3606;3458	IL-18;IFN-gamma	However , IL-12 and ***IL-18*** together fully ***induce*** ***IFN-gamma*** transcription independently of TCR-activated signals , by a mechanism that does not simply involve Stat4 and NF-kappaB activation , but requires additional protein synthesis .	target	1
454	10064078	959;958	CD40L;CD40	These results show that the ***CD40-CD40*** ***ligand*** ( ***CD40L*** ) interaction in vivo is essential for anergy induction and the subsequent development of immunodeficiency and pathologic expansion of lymphocytes .	parallel	1
455	10064078	958;959	CD40;CD40L	Our data demonstrate that antibody class switch to IgE and IgG1 can be induced by a retroviral infection in vivo even in the absence of ******CD40-CD40L****** ***interaction*** and an apparent switch to a Th2 cytokine production .	parallel	1
456	10064085	3458;6354	interferon-gamma;monocyte chemotactic protein-3	Differential ***induction*** of ***monocyte chemotactic protein-3*** in mononuclear leukocytes and fibroblasts by interferon-alpha/beta and ***interferon-gamma*** reveals MCP-3 heterogeneity .	target	1
457	10064088	3579;2919	CXCR2;GRO-alpha	Consequently , inhibition experiments with blocking peptide analogues and monoclonal antibodies revealed that ***GRO-alpha*** and its ***receptor*** ***CXCR2*** but not MCP-1 and its receptors substantially contributed to conversion of rolling into firm , shear-resistant arrest of monocytes to TNF-alpha-stimulated endothelium in physiological flow .	parallel	1
458	10064103	4790;7056	NF-kappaB;thrombomodulin	***NF-kappaB*** binding activity ***correlated*** with the degree of albuminuria ( r = 0.316 ) and with ***thrombomodulin*** plasma concentrations ( r = 0.33 ) , indicative for albuminuria associated endothelial dysfunction .	parallel	0
459	10064583	1999;2060	Ese1;Eps15	***Ese1*** is constitutively ***associated*** with ***Eps15*** proteins to form a complex with at least 14 protein-protein interaction surfaces .	parallel	0
460	10064589	1026;4217	p21;ASK1	Biochemical analysis showed that cytoplasmic ***p21*** ( Cip1/WAF1 ) forms a ***complex*** with the apoptosis signal-regulating kinase 1 ( ***ASK1*** ) and inhibits stress-activated MAP kinase cascade .	parallel	1
461	10064598	2950;5599	GSTp;JNK	***Regulation*** of ***JNK*** signaling by ***GSTp*** .	target	1
462	10064598	5599;2950	JNK;GSTp	UV irradiation or H2O2 treatment caused GSTp oligomerization and dissociation of the ******GSTp-JNK****** ***complex*** , indicating that it is the monomeric form of GSTp that elicits JNK inhibition .	parallel	1
463	10064598	5599;3725	JNK;Jun	Addition of purified GSTp to the ******Jun-JNK****** ***complex*** caused a dose-dependent inhibition of JNK activity .	parallel	1
464	10064598	2950;5599	GSTp;JNK	Conversely , immunodepleting ***GSTp*** from protein extracts ***attenuated*** ***JNK*** inhibition .	negative	0
465	10064598	2950;5599	GSTp;JNK	Forced expression of ***GSTp*** ***decreased*** MKK4 and ***JNK*** phosphorylation which coincided with decreased JNK activity , increased c-Jun ubiquitination and decreased c-Jun-mediated transcription .	negative	0
466	10064598	2950;6416	GSTp;MKK4	Forced expression of ***GSTp*** ***decreased*** ***MKK4*** and JNK phosphorylation which coincided with decreased JNK activity , increased c-Jun ubiquitination and decreased c-Jun-mediated transcription .	negative	0
467	10064598	2950;3725	GSTp;c-Jun	Forced expression of ***GSTp*** decreased MKK4 and JNK phosphorylation which coincided with decreased JNK activity , ***increased*** ***c-Jun*** ubiquitination and decreased c-Jun-mediated transcription .	positive	0
468	10064598	2950;5599	GSTp;JNK	Co-transfection of MEKK1 and GSTp restored MKK4 phosphorylation but did not affect ***GSTp*** ***inhibition*** of ***JNK*** activity , suggesting that the effect of GSTp on JNK is independent of the MEKK1-MKK4 module .	negative	1
469	10064599	79800;1387	calcium-responsive transcription factor;CREB-binding protein	***Recruitment*** of the coactivator ***CREB-binding protein*** , CBP , by the prototypical ***calcium-responsive transcription factor*** , CREB and stimulation of CBP activity by nuclear calcium signals is one mechanism through which calcium influx into excitable cells activates gene expression .	target	0
470	10064599	1385;1387	CREB;CREB-binding protein	***Recruitment*** of the coactivator ***CREB-binding protein*** , CBP , by the prototypical calcium-responsive transcription factor , ***CREB*** and stimulation of CBP activity by nuclear calcium signals is one mechanism through which calcium influx into excitable cells activates gene expression .	target	0
471	10064600	3725;1386	Jun;ATF-2	The human fibronectin promoter contains three CRE elements , one of which has been shown to bind a ******c-Jun-ATF-2****** ***heterodimer*** .	parallel	1
472	10064600	5599;1386	JNK;ATF-2	These results demonstrate that TGF-beta-mediated fibronectin induction requires activation of ***JNK*** which in turn ***modulates*** the activity of c-Jun and ***ATF-2*** in a Smad4independent manner .	target	0
473	10064600	5599;3725	JNK;Jun	These results demonstrate that TGF-beta-mediated fibronectin induction requires activation of ***JNK*** which in turn ***modulates*** the activity of ***c-Jun*** and ATF-2 in a Smad4independent manner .	target	0
474	10064601	2068;780	XPD;CAK	Western blot analysis and enzymatic assays indicate that XPD mutations affect the stoichiometric composition of TFIIH due to a weakness in the interaction between ******XPD-CAK****** ***complex*** and the core TFIIH , resulting in a partial reduction of transcription activity .	parallel	1
475	10064601	780;2068	CAK;TFIIH	Western blot analysis and enzymatic assays indicate that XPD mutations affect the stoichiometric composition of TFIIH due to a weakness in the ***interaction*** between ***XPD-CAK*** complex and the core ***TFIIH*** , resulting in a partial reduction of transcription activity .	parallel	1
476	10064601	2068;780	XPD;CAK	Western blot analysis and enzymatic assays indicate that XPD mutations affect the stoichiometric composition of TFIIH due to a weakness in the ***interaction*** between ******XPD-CAK****** complex and the core TFIIH , resulting in a partial reduction of transcription activity .	parallel	1
477	10064601	2068;2068	XPD;TFIIH	Western blot analysis and enzymatic assays indicate that XPD mutations affect the stoichiometric composition of TFIIH due to a weakness in the ***interaction*** between ***XPD-CAK*** complex and the core ***TFIIH*** , resulting in a partial reduction of transcription activity .	parallel	1
478	10064602	6777;595	STAT5;cyclin D1	Thus ***STAT5*** , in addition to ras signaling , appears to ***mediate*** transcriptional regulation of ***cyclin D1*** , thereby contributing to cytokine-dependent growth of hematopoietic cells .	target	0
479	10064602	6777;595	STAT5;cyclin D1	Transcriptional ***regulation*** of the ***cyclin D1*** promoter by ***STAT5*** : its involvement in cytokine-dependent growth of hematopoietic cells .	target	1
480	10064602	6776;595	STAT5A;cyclin D1	In NIH 3T3 cells , 1 * ***6-STAT5A*** and H-rasG12V individually and cooperatively ***transactivated*** the ***cyclin D1*** promoter in luciferase assays .	positive	1
481	10064602	6777;595	STAT5;cyclin D1	Both ***dn-STAT5*** and dn-ras ***suppressed*** IL-3-induced ***cyclin D1*** promoter activities in F-36P-mpl cells .	negative	1
482	10064602	6776;595	STAT5A;cyclin D1	Using a series of mutant cyclin D1 promoters , 1 * ***6-STAT5A*** was found to ***transactivate*** the ***cyclin D1*** promoter through the potential STAT-binding sequence at -481 bp .	positive	1
483	10064605	5591;6117	DNA-PKcs;RPA1	***DNA-PKcs*** ***interacted*** directly with ***RPA1*** in vitro .	parallel	1
484	10064617	3700;6348	gp120;MIP-1alpha	When preincubated with the CD4 + ve MM6 macrophage cell line , which expresses mRNA for the CCR3 and CCR5 chemokine receptors , both 3.7 and ***gp120*** ***inhibit*** binding of the chemokine ***MIP-1alpha*** .	negative	1
485	10064741	335;4018	Apolipoprotein A-I;lipoprotein	While low ***Apolipoprotein A-I*** ( apoA-I ) levels are primarily ***associated*** with increased high density ***lipoprotein*** ( HDL ) fractional catabolic rate ( FCR ) , the factors that regulate the clearance of HDL from the plasma are unclear .	parallel	0
486	10064788	4803;4790	NGF;NF-kappaB	***NF-kappaB*** was ***activated*** by ***NGF*** withdrawal in reversibly differentiated PC12 cells during dedifferentiation and reentry into the cell cycle , whereas in NGF/cAMP-differentiated cells , it was activated , at a late stage of the apoptotic process , concomitantly with cell death .	positive	1
487	10064822	5327;3082	tPA;HGF	These results are consistent with the hypothesis that HGF/SF plays a role in the development and maintenance of both the cerebral cortex and hippocampus , and that ***tPA*** may act as a ***regulator*** of ***HGF/SF*** activity in these structures .	target	1
488	10064822	4233;3082	c-met;hepatocyte growth factor	The expression of mRNAs for ***hepatocyte growth factor/scatter factor*** , its ***receptor*** ***c-met*** , and one of its activators tissue-type plasminogen activator show a systematic relationship in the developing and adult cerebral cortex and hippocampus .	parallel	1
489	10064822	4233;3082	c-met;hepatocyte growth factor	The temporal and spatial expression in brain of the mRNAs for the pleiotropic cytokine ***hepatocyte growth factor/scatter factor*** ( HGF/SF ) and its ***receptor*** ***c-met*** were compared to those of a known HGF/SF activator , tissue-type plasminogen activator ( tPA ) .	parallel	1
490	10065155	7157;4193	p53;MDM2	******MDM2-p53****** ***complexes*** in the nucleus are transported to the cytoplasm via signals present in the MDM2 protein , where p53 is degraded in the proteasome .	parallel	1
491	10065155	4193;7157	MDM2;p53	The transcription of the MDM2 oncogene is induced by the p53 protein after DNA damage , and the ***MDM2*** protein then ***binds*** to ***p53*** and blocks its activities as a tumour suppressor and promotes its degradation .	parallel	1
492	10065155	7157;4193	p53;MDM2	These two proteins thus form an autoregulatory feedback loop in which ***p53*** positively ***regulates*** MDM2 levels and ***MDM2*** negatively regulates p53 levels and activity .	positive	1
493	10065737	596;25	bcl2;v-abl	***bcl2*** and ***v-abl*** oncogenes ***cooperate*** to immortalize murine B cells that secrete antigen specific antibodies .	parallel	0
494	10065743	940;942	CD28;CD86	The expression of ***CD28*** was decreased on T cells of HIV-infected individuals and was negatively ***correlated*** to the expression of HLA-DR and ***CD86*** ( mean CD28 within CD3 + T cells : HIV + 29.5 % , HIV - 67.6 % ; correlation coefficient , - 0.75 and - 0.71 , respectively ) .	negative	0
495	10065863	7039;3973	TGFalpha;LHR	EGF and ***TGFalpha*** ***suppress*** oestradiol synthesis at a step beyond the production of cAMP and also ***LHR*** binding with more effect in granulosa cells from polycystic ovaries .	negative	1
496	10065895	7035;2152	tissue factor pathway inhibitor;tissue factor	Plasma ***tissue factor pathway inhibitor*** levels ***correlated*** positively with plasma ***tissue factor*** and prothrombin fragment 1 +2 levels .	positive	0
497	10065947	3553;7124	IL-1beta;TNFalpha	In this study , the ***effects*** and interactions between ***IL-1beta*** and ***TNFalpha*** on prostaglandin production and its regulation were investigated .	parallel	0
498	10065947	3553;5743	IL-1beta;cyclooxygenase-2	Furthermore , ***IL-1beta*** and , to a lesser extent , TNFalpha ***induced*** the expression of ***cyclooxygenase-2*** ( COX-2 ) mRNA .	target	1
499	10065947	7124;5743	TNFalpha;cyclooxygenase-2	Furthermore , IL-1beta and , to a lesser extent , ***TNFalpha*** ***induced*** the expression of ***cyclooxygenase-2*** ( COX-2 ) mRNA .	target	1
500	10065947	3553;5743	IL-1beta;COX-2	Simultaneous addition of ***IL-1beta*** and TNFalpha synergistically ***enhanced*** ***COX-2*** mRNA levels , accompanied by a corresponding stimulation of PGE2 synthesis .	positive	0
501	10065947	7124;5743	TNFalpha;COX-2	Simultaneous addition of IL-1beta and ***TNFalpha*** synergistically ***enhanced*** ***COX-2*** mRNA levels , accompanied by a corresponding stimulation of PGE2 synthesis .	positive	0
502	10065947	3553;5742	IL-1beta;COX-1	Neither ***IL-1beta*** , TNFalpha , nor the combination of these two cytokines ***affected*** ***COX-1*** mRNA levels .	target	0
503	10065947	7124;5742	TNFalpha;COX-1	Neither IL-1beta , ***TNFalpha*** , nor the combination of these two cytokines ***affected*** ***COX-1*** mRNA levels .	target	0
504	10066081	3482;3481	M6P/IGF2R;IGF2	Evidence for this statement includes : a ) breast cancers are infiltrated with IGF2 expressing stromal cells ; b ) mannose ***6-phosphate/IGF2*** ***receptor*** ( ***M6P/IGF2R*** ) is mutated in breast cancer , leading to loss of IGF2 degradation ; c ) IGF1R is overexpressed by malignant breast epithelial cells , and in some cases IGF1R is amplified ; and d ) complex changes in IGF binding protein expression occur during breast cancer progression which most likely also affect IGF1 and 2 signaling .	parallel	1
505	10066262	2047;1948	EphB1;ephrin-B2	In addition , we show that ephrin-B2 expression is upregulated by cocaine and amphetamine in adult mice , suggesting that ******ephrin-B2/EphB1****** ***interaction*** may play a role in drug-induced plasticity in adults as well .	parallel	1
506	10066375	7040;1191	Transforming growth factor beta-1;clusterin	***Transforming growth factor beta-1*** ***up-regulates*** ***clusterin*** synthesis in thyroid epithelial cells .	positive	1
507	10066377	5601;5599	SAPK;JNK	VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and ******SAPK/JNK****** ***signaling*** .	parallel	0
508	10066377	7422;5594	VEGF;ERK2	***VEGF*** ***activated*** the phosphorylation of extracellular signal regulated kinase (ERK)1 ( p44 mitogen-activated protein kinase ; MAPK ) and ***ERK2*** ( p42 MAPK ) in a time - and concentration-dependent manner .	positive	1
509	10066377	7422;5595	VEGF;extracellular signal regulated kinase (ERK)1	***VEGF*** ***activated*** the phosphorylation of ***extracellular signal regulated kinase (ERK)1*** ( p44 mitogen-activated protein kinase ; MAPK ) and ERK2 ( p42 MAPK ) in a time - and concentration-dependent manner .	positive	1
510	10066377	7422;5599	VEGF;JNK	Activation of the MAPK pathway together with ***inhibition*** of ***SAPK/JNK*** activity by ***VEGF*** appears to be a key event in determining whether an endothelial cell survives or undergoes programmed cell death .	negative	1
511	10066377	7422;5601	VEGF;SAPK	Activation of the MAPK pathway together with ***inhibition*** of ***SAPK/JNK*** activity by ***VEGF*** appears to be a key event in determining whether an endothelial cell survives or undergoes programmed cell death .	negative	1
512	10066378	841;836	caspase-8;caspase-3	These results do not support an alternative pathway in which ***caspase-8*** directly ***activates*** ***caspase-3*** .	positive	1
513	10066421	5801;5594	PTPBR7;ERK	When overexpressed in mammalian cells , wild-type ***PTPBR7*** ***suppressed*** the phosphorylation and activation of ***ERK*** by epidermal growth factor ( EGF ) , nerve growth factor ( NGF ) , and constitutively active MEK1 , a mutant MAPK kinase .	negative	1
514	10066434	4790;4792	NF-kappaB;IkappaBalpha	Moreover , the putative IkappaBalpha-Ub ligase ( IkappaBalpha-E3 ) present in HeLa cell cytosol associated in vitro with an IKK-phosphorylated recombinant IkappaBalpha , a process independent of ***NF-kappaB*** ***binding*** to ***IkappaBalpha*** or TNFalpha stimulation .	parallel	1
515	10066434	4790;7124	NF-kappaB;TNFalpha	Moreover , the putative IkappaBalpha-Ub ligase ( IkappaBalpha-E3 ) present in HeLa cell cytosol associated in vitro with an IKK-phosphorylated recombinant IkappaBalpha , a process independent of ***NF-kappaB*** ***binding*** to IkappaBalpha or ***TNFalpha*** stimulation .	parallel	1
516	10066445	7422;857	VEGF;caveolin-1	***VEGF*** ***induces*** nuclear translocation of Flk-1 / KDR , endothelial nitric oxide synthase , and ***caveolin-1*** in vascular endothelial cells .	target	1
517	10066664	5265;1991	alpha-1-protease inhibitor;neutrophil elastase	Interleukin-8 ( IL-8 ) , tumor necrosis factor alpha ( TNF-alpha ) , ******neutrophil elastase-alpha-1-protease inhibitor****** ***complex*** ( NE complex ) , protein , and alpha-1-protease inhibitor ( alpha-1-PI ) were measured in serum and sputum collected from CF patients during respiratory exacerbations and periods of well-being .	parallel	1
518	10066673	4790;3383	NF-kappaB;ICAM-1	Decoy ***NF-kappaB*** but not control oligonucleotides ***blocked*** ***ICAM-1*** upregulation and inhibited the subacute increase in PMN adhesion .	negative	0
519	10066681	387;5594	RhoA;ERK2	Overexpression of the Rho GDP dissociation inhibitor ( Rho-GDI ) , dominant-negative mutants of ***RhoA*** ( DNRhoA ) , or DNRac1 significantly ***inhibited*** stretch-induced activation of transfected ***ERK2*** .	positive	1
520	10066731	387;1609	RhoA;DGKtheta	Through accumulation of newly produced diacylglycerol , ***RhoA-mediated*** ***inhibition*** of ***DGKtheta*** may lead to enhanced PKC activity in response to external stimuli .	negative	1
521	10066731	387;1609	RhoA;Diacylglycerol kinase theta	***Diacylglycerol kinase theta*** binds to and is negatively ***regulated*** by active ***RhoA*** .	negative	1
522	10066731	1609;387	DGKtheta;RhoA	We now report that ***DGKtheta*** ***binds*** specifically to activated ***RhoA*** in transfected COS cells as well as in nontransfected neuronal N1E-115 cells .	parallel	1
523	10066731	387;1609	RhoA;DGKtheta	Strikingly , the ***binding*** of activated ***RhoA*** to ***DGKtheta*** completely inhibits DGK catalytic activity .	parallel	1
524	10066731	387;1716	RhoA;DGK	Strikingly , the binding of activated ***RhoA*** to DGKtheta completely ***inhibits*** ***DGK*** catalytic activity .	negative	1
525	10066740	1191;213	Clusterin;albumin	Enzyme-linked immunosorbent assay data showed that ***Clusterin*** ***bound*** preferentially to heat-stressed glutathione S-transferase and to dithiothreitol-treated bovine serum ***albumin*** and alpha-lactalbumin .	parallel	1
526	10066754	369;5609	A-Raf;MEK	However , dominant negative ***A-Raf*** effectively ***blocked*** ***MEK*** activation , suggesting that activation of the MEK-ERK signaling cascade is mediated through A-Raf .	negative	0
527	10066760	26279;22925	sPLA2s;M-type receptor	Both mouse group IB and group IIA ***sPLA2s*** are high affinity ***ligands*** ( in the 1-10 nM range ) for the mouse ***M-type receptor*** .	parallel	1
528	10066760	26279;22925	sPLA2s;M-type receptor	These two sPLA2s are expressed in the mouse tissues where the M-type receptor is also expressed , making it likely that both types of ***sPLA2s*** are physiological ***ligands*** of the mouse ***M-type receptor*** .	parallel	1
529	10066769	7040;1634	TGF-beta1;decorin	***decorin*** synthesis was ***reduced*** by either ***TGF-beta1*** or serum .	negative	1
530	10066772	3848;3827	cytokeratin 1;high molecular weight kininogen	Human ***cytokeratin 1*** ( CK1 ) in human umbilical vein endothelial cells ( HUVEC ) is expressed on their membranes and is able to ***bind*** ***high molecular weight kininogen*** ( HK ) ( Hasan , A.	parallel	1
531	10066780	1387;1045	CREB-binding [corrected] protein;Cdx2	***CREB-binding [corrected] protein*** ***interacts*** with the homeodomain protein ***Cdx2*** and enhances transcriptional activity .	parallel	1
532	10066798	5594;5601	p38;Jun kinase	pp60 ( v-src ) induction of cyclin D1 requires collaborative ***interactions*** between the extracellular signal-regulated kinase , ***p38*** , and ***Jun kinase*** pathways .	parallel	1
533	10066820	3553;4790	IL-1beta;NF-kappaB	Moreover , wortmannin had no effect on LPS - or ***IL-1beta-mediated*** ***activation*** of MAP kinase and ***NF-kappaB*** , suggesting that wortmannin induced the expression of iNOS in LPS - or IL-1beta-stimulated C6 glial cells without modulating the activation of MAP kinase and NF-kappaB .	positive	1
534	10066823	3059;2268	HS1;c-Fgr	We also show that a stable ***association*** of ***phospho-HS1*** with ***c-Fgr*** through its SH2 domain requires previous autophosphorylation of the kinase and is prevented by subsequent phosphorylation of Tyr-222 .	parallel	0
535	10066849	7056;5624	thrombomodulin;protein C	BACKGROUND AND PURPOSE : ***Activation*** of plasma ***protein C*** ( PC ) zymogen by ***thrombin-thrombomodulin*** at the endothelial surface is an important endogenous antithrombotic mechanism .	positive	1
536	10066882	5741;113091	PTH;PTH2	In an analogous manner , the presence of two receptors , PTH/PTHrP ( PTH1 ) and PTH2 , which differ in their ligand selectivity ( ***PTH2*** is ***activated*** by ***PTH*** , not PTHrP ) has provided a unique vehicle for probing the structural motifs of the receptor required for ligand recognition and binding .	positive	1
537	10067818	2950;2947	GSTP1;GSTM3	The ***associations*** between larynx cancer risk and ***GSTM3*** and ***GSTP1*** gene polymorphisms , either separately or in combination with GSTM1 and GSTT1 gene polymorphisms , were evaluated using peripheral blood DNA from 129 cancer patients and 172 controls , all regular smokers .	parallel	0
538	10067826	796;799	Calcitonin;calcitonin receptor	***Calcitonin-dependent*** ***down-regulation*** of the mouse C1a ***calcitonin receptor*** in cells of the osteoclast lineage involves a transcriptional mechanism .	negative	1
539	10067826	799;796	CTR;Calcitonin	Although expression of the ***Calcitonin*** ( CT ) ***receptor*** ( ***CTR*** ) decreases after CT binding , there has been no evidence that it occurs at the transcriptional level .	parallel	1
540	10067827	2247;3082	Fibroblast growth factor-2;scatter factor	***Fibroblast growth factor-2*** ***induces*** ***hepatocyte growth factor/scatter factor*** expression in osteoblasts .	target	1
541	10067828	5741;5950	PTH;RBP	Further , both ***PTH*** and ( Bu ) 2cAMP markedly ***induced*** the expression of ***RBP*** mRNA by about 10-fold at 3 h and by about 40-fold at 24 h , indicating a pretranslational regulation .	target	1
542	10067851	5741;2353	PTH;c-fos	***PTH*** ***induces*** ***c-fos*** expression rapidly and transiently in osteoblastic cells and requires the activity of the cAMP response element-binding protein ( CREB ) .	target	1
543	10067851	5741;1385	PTH;CREB	***PTH*** ***increases*** the level of phosphorylation of ***CREB*** at S133 in a time - and dose-dependent manner , correlating with the time and level of activation of PKA in response to PTH .	positive	0
544	10067855	116;820	PACAP;cAMP	Both ***PACAP*** and VIP ***stimulated*** ***cAMP*** accumulation through the cloned receptor with an EC50 of about 30 nM .	positive	0
545	10067856	5741;5744	PTH;PTHrP	A point mutation in the third cytoplasmic loop ( K382A ) that severely impairs ******PTH/PTHrP****** receptor ***signaling*** significantly reduced internalization , whereas two mutant receptors that displayed only partial defects in signaling were internalized normally .	parallel	0
546	10067858	2798;5594	GnRH receptor;p38	Separation of phosphorylated proteins by ion exchange chromatography suggested that ***GnRH receptor*** stimulation can ***activate*** the ***p38*** MAPK pathway .	positive	1
547	10067858	2796;5594	GnRH;p38	Immunoblot analysis of whole cell lysates using a phospho-specific antibody directed against dual phosphorylated p38 kinase revealed that ***GnRH-induced*** ***phosphorylation*** of ***p38*** kinase was dose and time dependent and was correlated with increased p38 kinase activity in vitro .	target	1
548	10067876	2626;3623	GATA-4;inhibin alpha	Cotransfection studies using a GATA-4 expression plasmid and an inhibin alpha promoter/reporter gene construct in Leydig and granulosa tumor cell lines revealed that the ***inhibin alpha*** promoter harboring essential GATA-binding sites can be ***trans-activated*** by ***GATA-4*** .	positive	1
549	10067896	3716;6772	Jak1;Stat1	TGF-beta signals through a receptor serine kinase that phosphorylates and activates the transcription factors Smads 2 and 3 , whereas the IFN-gamma receptor and its associated protein tyrosine kinase ***Jak1*** ***mediate*** phosphorylation and activation of the transcription factor ***Stat1*** .	target	0
550	10067896	7040;4088	TGF beta;Smad3	IFN-gamma inhibits the ***TGF beta-induced*** ***phosphorylation*** of ***Smad3*** and its attendant events , namely , the association of Smad3 with Smad4 , the accumulation of Smad3 in the nucleus , and the activation of TGFbeta-responsive genes .	target	1
551	10067896	3458;4088	IFN-gamma;Smad3	***IFN-gamma*** ***inhibits*** the TGF beta-induced phosphorylation of ***Smad3*** and its attendant events , namely , the association of Smad3 with Smad4 , the accumulation of Smad3 in the nucleus , and the activation of TGFbeta-responsive genes .	negative	1
552	10067896	4088;4089	Smad3;Smad4	IFN-gamma inhibits the TGF beta-induced phosphorylation of Smad3 and its attendant events , namely , the ***association*** of ***Smad3*** with ***Smad4*** , the accumulation of Smad3 in the nucleus , and the activation of TGFbeta-responsive genes .	parallel	0
553	10067896	3458;4092	IFN-gamma;Smad7	Acting through Jak1 and Stat1 , ***IFN-gamma*** ***induces*** the expression of ***Smad7*** , an antagonistic SMAD , which prevents the interaction of Smad3 with the TGF-beta receptor .	target	1
554	10067896	4092;4088	Smad7;Smad3	Acting through Jak1 and Stat1 , IFN-gamma induces the expression of ***Smad7*** , an antagonistic SMAD , which ***prevents*** the interaction of ***Smad3*** with the TGF-beta receptor .	negative	0
555	10067969	824;4284	m-calpain;MIP	***MIP*** ***cleavage*** by ***m-calpain*** was carried out by incubation with purified enzyme , and peptides released from the membrane were analyzed by Edman sequencing .	target	1
556	10068058	3561;3718	Gammac;JAK3	***Gammac*** is physically and functionally ***associated*** with the ***JAK3*** tyrosine kinase .	parallel	0
557	10068058	3600;6774	IL-15;STAT3	IL-2 , IL-7 , IL-9 and ***IL-15*** ***activate*** ***STAT3*** and STAT5 , in contrast to IL-4 , which activates STAT6 .	positive	1
558	10068058	3558;6774	IL-2;STAT3	***IL-2*** , IL-7 , IL-9 and IL-15 ***activate*** ***STAT3*** and STAT5 , in contrast to IL-4 , which activates STAT6 .	positive	1
559	10068058	3574;6774	IL-7;STAT3	IL-2 , ***IL-7*** , IL-9 and IL-15 ***activate*** ***STAT3*** and STAT5 , in contrast to IL-4 , which activates STAT6 .	positive	1
560	10068058	3578;6774	IL-9;STAT3	IL-2 , IL-7 , ***IL-9*** and IL-15 ***activate*** ***STAT3*** and STAT5 , in contrast to IL-4 , which activates STAT6 .	positive	1
561	10068058	3565;6778	IL-4;STAT6	IL-2 , IL-7 , IL-9 and IL-15 activate STAT3 and STAT5 , in contrast to ***IL-4*** , which ***activates*** ***STAT6*** .	positive	1
562	10068107	4233;3082	MET;hepatocyte growth factor	Western blot analyses and co-immunoprecipitations were used to investigate the association of proteins involved in epidermal growth factor and hepatocyte growth factor activation and signaling : epidermal growth factor receptor , ***hepatocyte growth factor*** ***receptor*** ( ***MET*** ) , urokinase-type plasminogen activator and its receptor , and a member of the signal transducer and activator of transcription family , STAT-3 .	parallel	1
563	10068204	5594;3791	ERK;VEGFR-2	In the first trimester trophoblast cells , PIGF-1 increased the association of phosphorylated extracellular signal-related kinase ( ERK ) with VEGFR-1 immunoprecipitates while both PIGF-1 and PIGF-2 also potentiated endogenous VEGF mediated ***association*** of phosphorylated extracellular related kinase ( ***ERK*** ) with ***VEGFR-2*** ( KDR ) .	parallel	0
564	10068344	3572;3569	gp130;IL-6	Sequential immunoprecipitation and immunoblotting were performed to assay for expression of the signal-transducing component of the ***IL-6*** ***receptor*** , ***gp130*** .	parallel	1
565	10068443	3308;7421	Hsp 70;VDR	These results suggest that ***DnaK/Hsp 70*** may ***interact*** with ***VDR*** prior to the activation of the latter by 1,25 ( OH ) 2D3-binding .	parallel	1
566	10068454	1674;419	desmin;mono-ADP-ribosyltransferase	Previous studies have shown that ***desmin*** , the muscle-specific intermediate filament protein , is a ***substrate*** for the endogenous muscle arginine-specific ***mono-ADP-ribosyltransferase*** and that ADP-ribosylation inhibits assembly of desmin into intermediate filaments ( Huang et al. , Exp .	parallel	1
567	10068462	5933;1871	p107;E2F3	While ***p107*** is upregulated and ***interacts*** with the putative Rb target ***E2F3*** in neural precursor cells , our results indicate that it clearly can not restore normal E2F regulation .	parallel	1
568	10068472	8900;983	cyclin A1;Cdk1	In the testis , ***cyclin A1*** has been shown to ***bind*** both ***Cdk1*** and Cdk2 but we show here that cyclin A2 binds only Cdk2 .	parallel	1
569	10068472	8900;1017	cyclin A1;Cdk2	In the testis , ***cyclin A1*** has been shown to ***bind*** both Cdk1 and ***Cdk2*** but we show here that cyclin A2 binds only Cdk2 .	parallel	1
570	10068472	890;1017	cyclin A2;Cdk2	In the testis , cyclin A1 has been shown to bind both Cdk1 and Cdk2 but we show here that ***cyclin A2*** ***binds*** only ***Cdk2*** .	parallel	1
571	10068474	1111;995	Chk1;Cdc25C	***Chk1*** kinase , a DNA damage/replication G2 checkpoint kinase , has recently been shown to ***phosphorylate*** and inhibit ***Cdc25C*** , a Cdc2 Tyr-15 phosphatase , thereby directly linking the G2 checkpoint to negative regulation of Cdc2 .	target	1
572	10068590	5594;4843	ERK;iNOS	Thus , both the p38 and ***ERK*** pathways are involved in the ***up-regulation*** of ***iNOS*** and TNF production by murine macrophages , and specific inhibitors of these pathways block macrophage iNOS production even when added 1 h after activation of these cells .	positive	1
573	10068651	2549;5266	Gab1;PI-3	We previously found that the adapter protein ***Gab1*** ( 110 kD ) is tyrosine-phosphorylated and forms a ***complex*** with SHP-2 and ***PI-3*** kinase upon stimulation through either the interleukin-3 receptor ( IL-3R ) or gp130 , the common receptor subunit of IL-6-family cytokines .	parallel	1
574	10068651	2549;5781	Gab1;SHP-2	We previously found that the adapter protein ***Gab1*** ( 110 kD ) is tyrosine-phosphorylated and forms a ***complex*** with ***SHP-2*** and PI-3 kinase upon stimulation through either the interleukin-3 receptor ( IL-3R ) or gp130 , the common receptor subunit of IL-6-family cytokines .	parallel	1
575	10068651	2549;5781	Gab1;SHP-2	***Gab1*** and Gab2 were shown to be ***substrates*** for ***SHP-2*** in vitro .	parallel	1
576	10068651	9846;5781	Gab2;SHP-2	Gab1 and ***Gab2*** were shown to be ***substrates*** for ***SHP-2*** in vitro .	parallel	1
577	10068651	9846;5594	Gab2;ERK2	Overexpression of ***Gab2*** ***enhanced*** the gp130 or Src-related kinases-mediated ***ERK2*** activation as that of Gab1 did .	positive	0
578	10068651	9846;3572	Gab2;gp130	Overexpression of ***Gab2*** ***enhanced*** the ***gp130*** or Src-related kinases-mediated ERK2 activation as that of Gab1 did .	positive	0
579	10068653	7448;5502	Vitronectin;inhibitor-1	***Vitronectin*** ( VN ) ***binds*** to plasminogen activator ***inhibitor-1*** ( PAI-1 ) and integrins and may play an important role in the vascular response to injury by regulating fibrinolysis and cell migration .	parallel	1
580	10068666	3977;3976	LIFR;LIF	leukemia inhibitory factor ( LIF ) induces growth arrest and macrophage differentiation of mouse myeloid leukemic cells through the functional ***LIF*** ***receptor*** ( ***LIFR*** ) , which comprises a heterodimeric complex of the LIFR subunit and gp130 .	parallel	1
581	10068666	3572;3977	gp130;LIFR	leukemia inhibitory factor ( LIF ) induces growth arrest and macrophage differentiation of mouse myeloid leukemic cells through the functional LIF receptor ( LIFR ) , which comprises a heterodimeric ***complex*** of the ***LIFR*** subunit and ***gp130*** .	parallel	1
582	10068670	7422;7075	VEGF;tie-1	This study demonstrated that the release of soluble ***tie-1*** from endothelial cells is ***stimulated*** by inflammatory cytokines and ***VEGF*** through the activation of an endothelial membrane-associated metalloprotease .	positive	0
583	10068671	3439;6772	IFN-alpha;STAT1	***IFN-alpha*** ***enhanced*** tyrosine phosphorylation of ***STAT1*** , STAT3 , STAT4 , STAT5a , and STAT5b .	positive	0
584	10068671	3439;6774	IFN-alpha;STAT3	***IFN-alpha*** ***enhanced*** tyrosine phosphorylation of STAT1 , ***STAT3*** , STAT4 , STAT5a , and STAT5b .	positive	0
585	10068671	3439;6775	IFN-alpha;STAT4	***IFN-alpha*** ***enhanced*** tyrosine phosphorylation of STAT1 , STAT3 , ***STAT4*** , STAT5a , and STAT5b .	positive	0
586	10068671	3439;6776	IFN-alpha;STAT5a	***IFN-alpha*** ***enhanced*** tyrosine phosphorylation of STAT1 , STAT3 , STAT4 , ***STAT5a*** , and STAT5b .	positive	0
587	10068671	3439;6777	IFN-alpha;STAT5b	***IFN-alpha*** ***enhanced*** tyrosine phosphorylation of STAT1 , STAT3 , STAT4 , STAT5a , and ***STAT5b*** .	positive	0
588	10068671	3600;6777	IL-15;STAT5	IL-12 induced STAT4 and IL-2 and ***IL-15*** ***induced*** ***STAT5*** binding to the GAS elements .	target	1
589	10068671	6774;6772	STAT3;STAT1	When we analyzed the nature of STAT proteins capable of binding to IL-2Ralpha , pim-1 , and IRF-1 GAS elements after cytokine stimulation , we observed IFN-alpha-induced ***binding*** of ***STAT1*** , ***STAT3*** , and STAT4 , but not STAT5 to all of these elements .	parallel	1
590	10068671	6774;6775	STAT3;STAT4	When we analyzed the nature of STAT proteins capable of binding to IL-2Ralpha , pim-1 , and IRF-1 GAS elements after cytokine stimulation , we observed IFN-alpha-induced ***binding*** of STAT1 , ***STAT3*** , and ***STAT4*** , but not STAT5 to all of these elements .	parallel	1
591	10068671	6775;6772	STAT4;STAT1	When we analyzed the nature of STAT proteins capable of binding to IL-2Ralpha , pim-1 , and IRF-1 GAS elements after cytokine stimulation , we observed IFN-alpha-induced ***binding*** of ***STAT1*** , STAT3 , and ***STAT4*** , but not STAT5 to all of these elements .	parallel	1
592	10068671	3439;6777	IFN-alpha;STAT5	Yet , ***IFN-alpha*** was able to ***activate*** binding of ***STAT5*** to the high-affinity IFP53 GAS site .	positive	1
593	10068671	6777;7453	STAT5;IFP53	Yet , IFN-alpha was able to activate ***binding*** of ***STAT5*** to the high-affinity ***IFP53*** GAS site .	parallel	1
594	10068674	26191;867	Lyp1;proto-oncogene c-Cbl	***Lyp1*** was found to be constitutively ***associated*** with the ***proto-oncogene c-Cbl*** in thymocytes and T cells .	parallel	0
595	10068674	26191;867	Lyp1;Cbl	Overexpression of ***Lyp1*** ***reduces*** ***Cbl*** tyrosine phosphorylation , suggesting that it may be a substrate of the phosphatase .	negative	1
596	10068683	5269;1511	PI-6;cathepsin G	Native ***cathepsin G*** and recombinant ***PI-6*** formed an SDS-stable ***complex*** in vitro similar in size to that observed in the extracts .	parallel	1
597	10068683	5269;1511	PI-6;cathepsin G	Further kinetic analysis demonstrated that ***cathepsin G*** and ***PI-6*** rapidly form a tight 1:1 ***complex*** ( ka = 6.8 + / - 0.2 x 10 ( 6 ) mol/L -1 s-1 at 17 degrees C ; Ki = 9.2 + / - 0.04 x 10 ( -10 ) mol/L ) .	parallel	1
598	10068868	4880;133	CNP;ADM	These data indicate that circulating ***CNP*** is not involved in the ***regulation*** of ***ADM*** release , renal haemodynamics and sodium excretion in man .	target	1
599	10069452	7040;5743	TGF-beta1;COX-2	***TGF-beta1*** ***induced*** the expression of ***COX-2*** mRNA and protein in intestinal epithelial cells ( IEC-6 ) .	target	1
600	10069452	7040;5743	TGF-beta1;COX-2	***TGF-beta1*** may ***regulate*** ***COX-2*** expression during the colonic adenoma to carcinoma sequence .	target	1
601	10069525	6343;885	secretin;CCK	***secretin*** significantly ( P < 0.005-P < 0.05 ) ***increased*** volume and bicarbonate output and ***CCK*** significantly ( P < 0.01 ) increased the output of bilirubin , pancreatic enzymes , bicarbonate and volume , both during normoglycemia and hyperglycemia .	positive	0
602	10069661	3479;2690	IGF-I;GHBP	The insulin and free fatty acid ( FFA ) areas under curves ( AUC ) during the OGTT , and the ***IGF-I*** level , were also positively ***correlated*** with ***GHBP*** levels ( r = 0.474 , P < 0.005 ; r = 0.572 , P < 0.005 ; r = 0.453 .	positive	0
603	10069682	185;183	AT1R;angiotensin II	It is presently unknown if newer specific ***angiotensin II*** subtype 1 ***receptor*** ( ***AT1R*** ) antagonists are as effective or more effective in treating these conditions compared with ACE inhibitors .	parallel	1
604	10069879	3439;3596	IFN-alpha;IL-13	CONCLUSION : ***IFN-alpha*** differentially ***regulates*** antigen-stimulated IL-4 and ***IL-13*** generation .	target	1
605	10069879	3439;3565	IFN-alpha;IL-4	CONCLUSION : ***IFN-alpha*** differentially ***regulates*** antigen-stimulated ***IL-4*** and IL-13 generation .	target	1
606	10069879	3439;3596	IFN-alpha;IL-13	Differential ***regulation*** of antigen-induced IL-4 and ***IL-13*** generation from T lymphocytes by ***IFN-alpha*** .	target	1
607	10069879	3439;3565	IFN-alpha;IL-4	Differential ***regulation*** of antigen-induced ***IL-4*** and IL-13 generation from T lymphocytes by ***IFN-alpha*** .	target	1
608	10069890	6367;729230	MDC;CCR2	***MDC*** ***binds*** to CC chemokine receptor 4 ( CCR4 ) but not to CCR1 , ***CCR2*** , CCR3 , CCR5 , CCR6 , or CCR7 .	parallel	1
609	10069890	6367;1232	MDC;CCR3	***MDC*** ***binds*** to CC chemokine receptor 4 ( CCR4 ) but not to CCR1 , CCR2 , ***CCR3*** , CCR5 , CCR6 , or CCR7 .	parallel	1
610	10069890	6367;1234	MDC;CCR5	***MDC*** ***binds*** to CC chemokine receptor 4 ( CCR4 ) but not to CCR1 , CCR2 , CCR3 , ***CCR5*** , CCR6 , or CCR7 .	parallel	1
611	10069890	6367;1235	MDC;CCR6	***MDC*** ***binds*** to CC chemokine receptor 4 ( CCR4 ) but not to CCR1 , CCR2 , CCR3 , CCR5 , ***CCR6*** , or CCR7 .	parallel	1
612	10069890	6367;1236	MDC;CCR7	***MDC*** ***binds*** to CC chemokine receptor 4 ( CCR4 ) but not to CCR1 , CCR2 , CCR3 , CCR5 , CCR6 , or ***CCR7*** .	parallel	1
613	10069890	6367;7852	MDC;chemokine receptor 4	***MDC*** ***binds*** to CC ***chemokine receptor 4*** ( CCR4 ) but not to CCR1 , CCR2 , CCR3 , CCR5 , CCR6 , or CCR7 .	parallel	1
614	10069998	7124;6352	TNF-alpha;RANTES	Correction of the CF transmembrane conductance regulator ( CFTR ) defect in CF airway epithelial cells restored the ***induction*** of ***RANTES*** protein and mRNA by ***TNF-alpha*** in combination with IFN-gamma ( P < / = 0.05 ) but had little effect on IL-8 or MCP-1 production compared with mock controls .	target	1
615	10070011	3976;4322	Leukemia inhibitory factor;collagenase-3	***Leukemia inhibitory factor*** and oncostatin M ***stimulate*** ***collagenase-3*** expression in osteoblasts .	positive	0
616	10070011	5008;4322	oncostatin M;collagenase-3	Leukemia inhibitory factor and ***oncostatin M*** ***stimulate*** ***collagenase-3*** expression in osteoblasts .	positive	0
617	10070011	3976;4322	LIF;collagenase-3	***LIF*** and OSM ***increased*** ***collagenase-3*** ( MMP-13 ) mRNA and immunoreactive protein levels in a time - and dose-dependent manner .	positive	0
618	10070011	5008;4322	OSM;collagenase-3	LIF and ***OSM*** ***increased*** ***collagenase-3*** ( MMP-13 ) mRNA and immunoreactive protein levels in a time - and dose-dependent manner .	positive	0
619	10070011	3976;4322	LIF;collagenase-3	In conclusion , ***LIF*** and OSM ***stimulate*** ***collagenase-3*** and TIMP-1 expression in osteoblasts , and these effects may be involved in mediating the bone remodeling actions of these cytokines .	positive	0
620	10070011	5008;4322	OSM;collagenase-3	In conclusion , LIF and ***OSM*** ***stimulate*** ***collagenase-3*** and TIMP-1 expression in osteoblasts , and these effects may be involved in mediating the bone remodeling actions of these cytokines .	positive	0
621	10070021	3486;3481	IGFBP-3;IGF-II	These observations suggest the possibility of an autocrine ***IGF-II*** loop that is ***regulated*** by the relative expression of IGF-II , ***IGFBP-3*** , and IGFBP-6 , and IGFBP proteases in these keratinocytes , although demonstration of this loop requires further study .	target	1
622	10070021	3489;3481	IGFBP-6;IGF-II	These observations suggest the possibility of an autocrine ***IGF-II*** loop that is ***regulated*** by the relative expression of IGF-II , IGFBP-3 , and ***IGFBP-6*** , and IGFBP proteases in these keratinocytes , although demonstration of this loop requires further study .	target	1
623	10070035	355;356	Fas;Fas ligand	******Fas-Fas ligand****** ***interactions*** in the intestinal mucosa may lead to complex signal transduction cascades and gene regulation that culminate in apoptosis , cytokine secretion , or other novel functions .	parallel	1
624	10070035	355;5599	Fas;JNK	***Fas*** ***activates*** the ***JNK*** pathway in human colonic epithelial cells : lack of a direct role in apoptosis .	positive	1
625	10070035	3458;355	IFN-gamma;Fas	***IFN-gamma*** ***increases*** expression of ***Fas*** on HT-29 cells .	positive	0
626	10070049	3484;3479	IGFBP-1;IGF-I	Because ***IGFBP-1*** ***inhibits*** many anabolic actions of ***IGF-I*** , increases in IGFBP-1 may be partly responsible for the decrease in lean body mass observed in catabolic/inflammatory conditions .	negative	1
627	10070167	551;3553	AVP;IL-1beta	***AVP*** ***inhibited*** lipopolysaccharide ( LPS ) - and interleukin-1beta ( ***IL-1beta*** ) - induced nitrite production in a dose - and time-dependent manner , with concomitant changes in cGMP content , iNOS mRNA , and iNOS protein .	negative	1
628	10070274	5970;4790	p65;p50	The complexes consisted of p50/p50 homodimers and ******p50/p65****** ***heterodimers*** .	parallel	1
629	10070307	1500;999	p120;E-cadherin	Our data indicate that the ******E-cadherin-p120****** ***complex*** may be a useful prognostic marker in bladder cancer .	parallel	1
630	10070366	7040;1009	transforming growth factor beta 1;cadherin-11	***transforming growth factor beta 1*** was shown to ***increase*** ***cadherin-11*** mRNA and protein expression in these cultured extravillous cytotrophoblasts in a dose-dependent manner .	positive	0
631	10070954	317;836	Apaf-1;caspase-9 and -3	It can also block ***activation*** of ***caspase-9 and -3*** by ***Apaf-1*** in an in vitro cytochrome c-dependent caspase activation assay .	positive	1
632	10070954	317;842	Apaf-1;caspase-9	These results suggest that caspase-9b functions as an endogenous apoptosis inhibitory molecule by interfering with the formation of a functional ******Apaf-1-caspase-9****** ***complex*** .	parallel	1
633	10070972	5979;1445	Ret;c-Src kinase	These experiments demonstrate that activated ***Ret*** is able to ***bind*** and stimulate ***c-Src kinase*** and that Src activation is essential for the mitogenic activity of Ret .	parallel	1
634	10071234	960;1509	CD44;cathepsin D	***CD44*** expression in carcinomas was positively ***correlated*** with tumour size ( P = 0.018 ) , tumour cells cathepsin D ( P = 0.022 ) , stromal cell ***cathepsin D*** ( P = 0.003 ) and Rb protein ( P = 0.021 ) .	positive	0
635	10071250	891;983	cyclin B1;cdc2	***cyclin B1*** ***activates*** ***cdc2*** , which regulates cell progression through the G2 and M phases .	positive	1
636	10071756	6752;6750	SSTR2;somatostatin	A microplate binding assay for the ***somatostatin*** type-2 ***receptor*** ( ***SSTR2*** ) .	parallel	1
637	10071756	6752;6750	SSTR2;somatostatin	The clinical importance of ***somatostatin*** type-2 ***receptors*** ( ***SSTR2*** ) and the study of novel analogues of somatostatin such as OctreoScan or [ Tyr3 ] - octreotide containing DOTA ( 1,4,7,10-tetraazacyclododecane-1 ,4,7,10 - tetraacetic acid ) as metal chelator led us to develop a methodology to monitor the expression of SSTR2 on tumours of pancreatic origin ( e.g. rat AR4-2J cancer cells ) .	parallel	1
638	10071757	3565;3596	IL-4;IL-13	After occupation of the shared high affinity receptors by the non-signaling , double mutant IL-4 ( 121 ) R -- > D , 124Y -- > D ( ***RY-IL-4*** ) the high affinity ***binding*** of ***IL-13*** could be abolished .	parallel	1
639	10071932	2597;3329	GAPDH;GroEL	The ***binding*** of denatured B. stearothermophilus D-glyceraldehyde-3-phosphate dehydrogenase ( ***GAPDH*** ) to the E. coli chaperonin ***GroEL*** was investigated in two systems : ( 1 ) GroEL immobilized on Sepharose via a single subunit was titrated with urea-denatured soluble GAPDH and ( 2 ) a Sepharose-bound denatured GAPDH monomer was titrated with soluble GroEL .	parallel	1
640	10072067	1385;4261	CREB;CIITA	Transient transactivation experiments showed that ***CREB*** can ***cooperate*** with ***CIITA*** to enhance activation of transcription from MHC class II promoters in a dose-dependent manner .	parallel	0
641	10072067	1385;4261	CREB;CIITA	These results demonstrate that ***CREB*** binds to the X2 box in vivo and ***cooperates*** with ***CIITA*** to direct MHC class II expression .	parallel	0
642	10072076	974;973	Ig-beta;Ig-alpha	BCR destabilization occurs at the cell surface and " dissociated " ******Ig-alpha/Ig-beta****** ***complexes*** remain responsive to anti-Ig-beta stimulation , suggesting that mIg-transducer uncoupling may mediate receptor desensitization .	parallel	1
643	10072079	1326;9020	Cot;NIK	Consistent with such a sequential function of these two kinases , ***Cot*** physically assembles with and ***phosphorylates*** ***NIK*** in vivo .	target	1
644	10072173	4838;4288	Nodal;MIB1	***Nodal*** involvement and vascular invasion were significantly ***associated*** with ***MIB1*** .	parallel	0
645	10072196	5443;4953	beta-endorphin;ODC	These results suggest that CNS ***beta-endorphin*** ***suppresses*** tissue ***ODC*** responsiveness to trophic hormones by downregulating the expression of c-myc and max mRNAs , the encoded proteins of which are known to act physiologically as transcriptional activators of the ODC gene .	negative	1
646	10072219	7040;7422	TGF-beta1;VEGF	These findings suggest that the production of ***VEGF*** is increased and may be ***upregulated*** by ***TGF-beta1*** in acute KD .	positive	1
647	10072388	3725;7157	c-Jun;p53	Rather , ***c-Jun*** ***regulates*** transcription of ***p53*** negatively by direct binding to a variant AP-1 site in the p53 promoter .	negative	1
648	10072389	4342;7465	Mos;Wee1	***Mos*** positively ***regulates*** ***Xe-Wee1*** to lengthen the first mitotic cell cycle of Xenopus .	positive	1
649	10072389	4342;7465	Mos;Wee1	These findings indicate that ***Mos*** positively ***regulates*** ***Xe-Wee1*** to generate the G2 phase in the first cell cycle and establish a direct link between the MAPK signal transduction pathway and Wee1 in vertebrates .	positive	1
650	10072445	4193;7157	MDM2;p53 tumor suppressor	BACKGROUND : The ***MDM2*** oncogene functions as a negative feedback ***regulator*** of the ***p53 tumor suppressor*** .	negative	1
651	10072486	3596;6356	IL-13;eotaxin	Effects of Th2 cytokines on chemokine expression in the lung : ***IL-13*** potently ***induces*** ***eotaxin*** expression by airway epithelial cells .	target	1
652	10072486	3565;6347	IL-4;monocyte-chemotactic protein-1	We tested the major cytokines individually and found that IL-4 and IL-5 induced higher levels of macrophage-inflammatory protein-1alpha and KC ; ***IL-4*** also ***increased*** the production of ***monocyte-chemotactic protein-1*** ; IL-13 and IL-4 induced eotaxin .	positive	0
653	10072486	3596;6356	IL-13;eotaxin	We tested the major cytokines individually and found that IL-4 and IL-5 induced higher levels of macrophage-inflammatory protein-1alpha and KC ; IL-4 also increased the production of monocyte-chemotactic protein-1 ; ***IL-13*** and IL-4 ***induced*** ***eotaxin*** .	target	1
654	10072486	3565;6356	IL-4;eotaxin	We tested the major cytokines individually and found that IL-4 and IL-5 induced higher levels of macrophage-inflammatory protein-1alpha and KC ; IL-4 also increased the production of monocyte-chemotactic protein-1 ; IL-13 and ***IL-4*** ***induced*** ***eotaxin*** .	target	1
655	10072486	3596;6356	IL-13;eotaxin	While TNF-alpha did not stimulate eotaxin production by itself , it markedly augmented ***eotaxin*** ***induction*** by ***IL-13*** .	target	1
656	10072486	3596;6356	IL-13;eotaxin	***IL-13*** was able to ***induce*** ***eotaxin*** in the lung of JAK3-deficient mice , suggesting that JAK3 is not required for IL-13 signaling in airway epithelial cells ; however , eosinophilia was not induced in this situation , suggesting that JAK3 transduces other IL-13-mediated mechanisms critical for eosinophil recruitment .	target	1
657	10072505	3700;920	gp120;CD4	As a follow up to our previous findings that gp17 binds to CD4 with high affinity and interferes with both HIV-1 ***gp120*** ***binding*** to ***CD4*** and syncytium formation , we investigated whether gp17 could affect the T lymphocyte apoptosis induced by a separate ligation of CD4 and TCR .	parallel	1
658	10072514	3565;6778	IL-4;STAT6	***IL-4*** preferentially ***activates*** a novel ***STAT6*** isoform in mast cells .	positive	1
659	10072520	3902;7124	Lymphocyte activation gene-3;TNF-alpha	***Lymphocyte activation gene-3*** , a MHC class II ligand expressed on activated T cells , ***stimulates*** ***TNF-alpha*** and IL-12 production by monocytes and dendritic cells .	positive	0
660	10072521	3600;799	IL-15;calcitonin receptor	Moreover , low ***IL-15*** concentration ( 0.1 ng/ml ) strongly ***increased*** the level of ***calcitonin receptor*** mRNA of mononuclear preosteoclast-like cells .	positive	0
661	10072521	3600;7124	IL-15;TNF-alpha	Although ***IL-15*** is known as a potent ***stimulator*** of ***TNF-alpha*** , its activity was not abolished by addition of anti-TNF-alpha Ab .	positive	0
662	10072547	3383;2017	ICAM-1;cortactin	***ICAM-1-stimulated*** tyrosine ***phosphorylation*** of the actin-associated molecule ***cortactin*** and ICAM-1-mediated , Ag/IL-2-stimulated T lymphocyte migration through EC monolayers were inhibited following pretreatment of EC with cytochalasin D.	target	1
663	10072548	7040;3458	TGF-beta;IFN-gamma	***TGF-beta*** has been reported to ***inhibit*** IL-12 - and IL-2-induced cell proliferation and ***IFN-gamma*** production by T cells and NK cells ; however , the mechanisms of inhibition have not been clearly defined .	negative	1
664	10072548	7040;3558	TGF-beta;IL-2	***TGF-beta*** has been reported to ***inhibit*** IL-12 - and ***IL-2-induced*** cell proliferation and IFN-gamma production by T cells and NK cells ; however , the mechanisms of inhibition have not been clearly defined .	negative	1
665	10072548	3558;3718	IL-2;JAK3	Similarly , but in contrast to previous reports , we found that TGF-beta1 did not inhibit ***IL-2-induced*** ***phosphorylation*** of JAK1 , ***JAK3*** , and STAT5A .	target	1
666	10072548	3558;6776	IL-2;STAT5A	Similarly , but in contrast to previous reports , we found that TGF-beta1 did not inhibit ***IL-2-induced*** ***phosphorylation*** of JAK1 , JAK3 , and ***STAT5A*** .	target	1
667	10072766	7538;7124	TTP;tumor necrosis factor alpha	Recent evidence suggests that a physiological function of ***TTP*** is to ***inhibit*** ***tumor necrosis factor alpha*** secretion from macrophages by binding to and destabilizing its mRNA ( Carballo , E. , Lai , W.S. , Blackshear , P.J. , 1998 .	negative	1
668	10072879	3569;7039	IL-6;TGF alpha	CONCLUSION : TGF alpha , TGF beta 1 , bFGF , ***IL-6*** , IL-8 and ANG may be involved in the autocrine ***regulation*** of the growth and proliferation of pulmonary giant cell carcinoma , ***TGF alpha*** and IL-6 may play an important role in the metastasis of the tumor cells .	target	1
669	10072879	3576;3569	IL-8;IL-6	CONCLUSION : TGF alpha , TGF beta 1 , bFGF , IL-6 , ***IL-8*** and ANG may be involved in the autocrine ***regulation*** of the growth and proliferation of pulmonary giant cell carcinoma , TGF alpha and ***IL-6*** may play an important role in the metastasis of the tumor cells .	target	1
670	10072879	3576;7039	IL-8;TGF alpha	CONCLUSION : TGF alpha , TGF beta 1 , bFGF , IL-6 , ***IL-8*** and ANG may be involved in the autocrine ***regulation*** of the growth and proliferation of pulmonary giant cell carcinoma , ***TGF alpha*** and IL-6 may play an important role in the metastasis of the tumor cells .	target	1
671	10072879	7039;3569	TGF alpha;IL-6	CONCLUSION : ***TGF alpha*** , TGF beta 1 , bFGF , IL-6 , IL-8 and ANG may be involved in the autocrine ***regulation*** of the growth and proliferation of pulmonary giant cell carcinoma , TGF alpha and ***IL-6*** may play an important role in the metastasis of the tumor cells .	target	1
672	10072879	7040;3569	TGF beta 1;IL-6	CONCLUSION : TGF alpha , ***TGF beta 1*** , bFGF , IL-6 , IL-8 and ANG may be involved in the autocrine ***regulation*** of the growth and proliferation of pulmonary giant cell carcinoma , TGF alpha and ***IL-6*** may play an important role in the metastasis of the tumor cells .	target	1
673	10072879	7040;7039	TGF beta 1;TGF alpha	CONCLUSION : TGF alpha , ***TGF beta 1*** , bFGF , IL-6 , IL-8 and ANG may be involved in the autocrine ***regulation*** of the growth and proliferation of pulmonary giant cell carcinoma , ***TGF alpha*** and IL-6 may play an important role in the metastasis of the tumor cells .	target	1
674	10072926	80312;2353	Tet 1;c-fos	***Tet 1*** , 2 , and 4 mg.kg-1 given by i.g. 30 min prior to lindane ***reduced*** ***c-fos*** gene expression in a concentration-dependent manner .	negative	1
675	10073575	3169;7031	HNF-3 alpha;pS2	In gel retardation assays , ***HNF-3 alpha*** and beta ***bound*** predominantly to the site in TFF1 ( formerly ***pS2*** ) and , to a lesser extent , to the sites in TFF2 or TFF3 .	parallel	1
676	10073576	3131;1628	HLF;DBP	Enhanced binding of ******HLF/DBP****** ***heterodimers*** represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes .	parallel	1
677	10073576	3131;1628	HLF;DBP	Enhanced ***binding*** of ******HLF/DBP****** heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes .	parallel	1
678	10073576	1628;3131	DBP;HLF	At least some of the synergistic activation of the Factor VIII promoter seen with HLF and DBP cotransfection can be attributed to increased binding of ******HLF-DBP****** ***heterodimers*** to two Factor VIII promoter sites .	parallel	1
679	10073576	3131;1628	HLF;DBP	These observations indicate that the PAR family of transcription factors plays an important and complex role in regulating expression of the Factor VIII and factor IX genes , involving the binding of both homodimeric and heterodimeric ***complexes*** of ***HLF*** and ***DBP*** to several sites in the promoters .	parallel	1
680	10073576	1628;3131	DBP;HLF	Finally , these studies reaffirm the potential role of dimeric transcription factor complexes in mediating interactions with specific promoter elements , which , in the case of the Factor VIII promoter , results in dramatically enhanced binding of ******HLF-DBP****** ***heterodimers*** to two cis-acting sequences .	parallel	1
681	10073597	4880;4882	CNP;NPR-B	In addition to NPR-A , which is bound by atrial natriuretic peptide ( ANP ) , brain natriuretic peptide ( BNP ) , and urodilatin ( URO ) , a novel form of ***NPR-B*** that might be ***bound*** by C-type natriuretic peptide ( ***CNP*** ) was identified using PCR .	parallel	1
682	10073683	3569;973	IL-6;IgA	Recently , we determined that IEC-derived ***IL-6*** and TGF-beta could ***enhance*** ***IgA*** secretion and suppress IgM secretion by isolated mucosal B cells .	positive	0
683	10073683	7040;973	TGF-beta;IgA	Recently , we determined that IEC-derived IL-6 and ***TGF-beta*** could ***enhance*** ***IgA*** secretion and suppress IgM secretion by isolated mucosal B cells .	positive	0
684	10073698	1026;5111	p21;proliferating cell nuclear antigen	The cdk-inhibitor ***p21*** ( CIP1/WAF1 ) ***inhibits*** the activities of cyclin-dependent kinases and ***proliferating cell nuclear antigen*** , thereby repressing cell-cycle progression and DNA replication .	negative	1
685	10073767	3479;3383	Insulin like growth factor-1;intercellular adhesion molecule-1	***Insulin like growth factor-1*** activates nuclear factor-kappaB and ***increases*** transcription of the ***intercellular adhesion molecule-1*** gene in endothelial cells .	positive	0
686	10073939	3226;9496	HoxC10;Tbx4	Misexpression of Pitx1 in the chick wing bud ***induced*** distal expression of ***Tbx4*** , as well as ***HoxC10*** and HoxC11 , which are normally restricted to hindlimb expression domains .	target	1
687	10073939	5307;3226	Pitx1;HoxC10	Misexpression of ***Pitx1*** in the chick wing bud ***induced*** distal expression of Tbx4 , as well as ***HoxC10*** and HoxC11 , which are normally restricted to hindlimb expression domains .	target	1
688	10073939	5307;9496	Pitx1;Tbx4	Misexpression of ***Pitx1*** in the chick wing bud ***induced*** distal expression of ***Tbx4*** , as well as HoxC10 and HoxC11 , which are normally restricted to hindlimb expression domains .	target	1
689	10073954	7124;7422	TNF-alpha;VEGF	***Cooperation*** between ***VEGF*** and ***TNF-alpha*** is necessary for exposure of active tissue factor on the surface of human endothelial cells .	parallel	0
690	10074122	6387;7852	SDF-1;CXCR4	The ***interaction*** of the chemokine stromal cell-derived factor 1 ( ***SDF-1*** ) with its receptor ***CXCR4*** is vital for cell trafficking during development , is capable of inhibiting human immunodeficiency virus type 1 ( HIV-1 ) utilization of CXCR4 as a coreceptor , and has been implicated in delaying disease progression to AIDS in vivo .	parallel	1
691	10074122	6387;7852	SDF-1;CXCR4	Using CXCR4 chimeras and mutants , we determined that ***SDF-1*** ***requires*** the ***CXCR4*** amino terminus for binding and activates downstream signaling pathways by interacting with the second extracellular loop of CXCR4 .	target	0
692	10074122	6387;7852	SDF-1;CXCR4	***SDF-1-mediated*** ***activation*** of ***CXCR4*** required the Asp-Arg-Tyr motif in the second intracellular loop of CXCR4 , was pertussis toxin sensitive , and did not require the distal C-terminal tail of CXCR4 .	positive	1
693	10074208	3553;3383	IL-1beta;ICAM-1	***Induction*** of interleukin-6 ( IL-6 ) and ***ICAM-1*** by ***IL-1beta*** was not suppressed by infection with EZ , suggesting that the inhibition of IFN signaling is specific .	target	1
694	10074208	3553;3569	IL-1beta;interleukin-6	***Induction*** of ***interleukin-6*** ( IL-6 ) and ICAM-1 by ***IL-1beta*** was not suppressed by infection with EZ , suggesting that the inhibition of IFN signaling is specific .	target	1
695	10074208	3553;4790	IL-1beta;NF-kappaB	In contrast , infection with EZ did not block ***activation*** of the transcription factor ***NF-kappaB*** by ***IL-1beta*** .	positive	1
696	10074428	8995;8784	hGITRL;GITR	We have identified a new TNF-related ligand , designated human ***GITR*** ***ligand*** ( ***hGITRL*** ) , and its human receptor ( hGITR ) , an ortholog of the recently discovered murine glucocorticoid-induced TNFR-related (mGITR) protein [ 4 ] .	parallel	1
697	10074428	8995;4790	hGITRL;NF-kappaB	Cotransfection of ***hGITRL*** and hGITR in embryonic kidney 293 cells ***activated*** the anti-apoptotic transcription factor ***NF-kappaB*** , via a pathway that appeared to involve TNFR-associated factor 2 ( TRAF2 ) [ 7 ] and NF-kappaB-inducing kinase ( NIK ) [ 8 ] .	positive	1
698	10074428	8784;4790	hGITR;NF-kappaB	Cotransfection of hGITRL and ***hGITR*** in embryonic kidney 293 cells ***activated*** the anti-apoptotic transcription factor ***NF-kappaB*** , via a pathway that appeared to involve TNFR-associated factor 2 ( TRAF2 ) [ 7 ] and NF-kappaB-inducing kinase ( NIK ) [ 8 ] .	positive	1
699	10074429	29765;10121	actin-capping protein;Arp1	In dynactin , the ***Arp1*** filament is ***bounded*** by ***actin-capping protein*** at one end and a heterotetrameric protein complex containing the p62 subunit ( D.M.	parallel	1
700	10074432	868;7535	Cbl-b;zap-70	A direct ***interaction*** between the adaptor protein ***Cbl-b*** and the kinase ***zap-70*** induces a positive signal in T cells .	parallel	1
701	10074432	868;7535	Cbl-b;zap-70	A loss-of-function mutation in Cbl-b disrupted the ***interaction*** between ***Cbl-b*** and ***zap-70*** and nearly completely abrogated the Cbl-b-mediated activation of NFAT .	parallel	1
702	10074433	8945;1499	beta-TrCP;beta-catenin	The F-box protein ***beta-TrCP*** ***associates*** with phosphorylated ***beta-catenin*** and regulates its activity in the cell .	parallel	0
703	10074433	8945;1499	beta-TrCP;beta-catenin	We found that the ***binding*** of ***beta-TrCP*** to ***beta-catenin*** was direct and dependent upon the WD40 repeat sequences in beta-TrCP and on phosphorylation of the GSK3beta sites in beta-catenin .	parallel	1
704	10074433	8945;1499	beta-TrCP;beta-catenin	Overexpression of wild-type ***beta-TrCP*** in mammalian cells ***promoted*** the downregulation of ***beta-catenin*** , whereas overexpression of a dominant-negative deletion mutant upregulated beta-catenin protein levels and activated signaling dependent on the transcription factor Tcf .	positive	0
705	10074455	2072;2067	XPF;ERCC1	Immunoblotting revealed that the testis tumour cells had normal amounts of most NER proteins , but low levels of the xeroderma pigmentosum group A protein ( XPA ) and the ******ERCC1-XPF****** endonuclease ***complex*** .	parallel	1
706	10074902	4193;84260	Mdm2;tumor suppressor protein	Degradation of the p53 ***tumor suppressor protein*** has been shown to be ***regulated*** by ***Mdm2*** .	target	1
707	10074903	7158;9338	p202;p21	Transient transfection of a p202-encoding plasmid in Saos-2 cells , which do not harbor a wild-type p53 protein , resulted in an increase in p21 protein , which indicated that ***p202*** could ***regulate*** expression of ***p21*** protein independent of p53 protein .	target	1
708	10074904	1026;1017	p21cip1;cyclin-dependent kinase 2	We propose that an appropriately timed induction of cyclin E/cyclin-dependent kinase 2 by HPV E7 in postmitotic cells enables S-phase reentry and HPV DNA amplification , whereas prematurely induced cyclin E stabilizes ***p21cip1*** protein , which then ***inhibits*** cyclin ***E/cyclin-dependent kinase 2*** .	negative	1
709	10074923	5443;2821	alpha-MSH;AMF	***alpha-MSH*** significantly ***blocked*** the autocrine motility factor ( ***AMF*** ) - enhanced cell motility .	negative	0
710	10074923	267;2821	gp78;AMF	However , alpha-MSH did neither prevent the secretion of AMF from B16-BL6 cells nor alter the expression level of ***AMF*** ***receptor*** ( ***gp78*** ) .	parallel	1
711	10074923	5443;2821	alpha-MSH;AMF	However , ***alpha-MSH*** did neither ***prevent*** the secretion of ***AMF*** from B16-BL6 cells nor alter the expression level of AMF receptor ( gp78 ) .	negative	0
712	10075017	7040;3558	TGF-beta1;IL-2	***TGF-beta1*** was able to ***inhibit*** ***IL-2*** synthesis by the activation of PKA and MAPK .	negative	1
713	10075021	3565;3660	IL-4;IRF-2	Furthermore , ***IL-4*** substantially ***augmented*** the IFN-gamma-induced expression of ***IRF-2*** , which is known to compete with IRF-1 for the DNA recognition site , ISRE ( interferon-stimulated response element ) .	positive	0
714	10075021	3660;3659	IRF-2;IRF-1	Our findings could indicate that IL-4 suppresses IFN-gamma-stimulated iNOS transcription by elevating the level of ***IRF-2*** which , through competition , ***prevents*** ***IRF-1*** from binding to ISRE in the iNOS promoter .	negative	0
715	10075021	3565;4843	IL-4;iNOS	Our findings could indicate that ***IL-4*** ***suppresses*** IFN-gamma-stimulated ***iNOS*** transcription by elevating the level of IRF-2 which , through competition , prevents IRF-1 from binding to ISRE in the iNOS promoter .	negative	1
716	10075082	4790;5970	p50;p65	Direct treatment of the ******p50-p65****** ***heterodimer*** of NF-kappaB with beta-lapachone had no effect on its ability to bind to the DNA .	parallel	1
717	10075644	9568;2550	gb2;gb1	Characterization of the tissue distribution of each of the receptors by in situ hybridization histochemistry in rat brain revealed co-localization of gb1 and gb2 transcripts in many brain regions , suggesting the hypothesis that ***gb1*** and ***gb2*** may ***interact*** in vivo .	parallel	1
718	10075656	1387;5468	CBP;PPARgamma	We show here that the ***interaction*** between ***p300/CBP*** and ***PPARgamma*** is complex and involves multiple domains in each protein .	parallel	1
719	10075656	2033;1387	p300;CBP	We show here that the ***interaction*** between ******p300/CBP****** and PPARgamma is complex and involves multiple domains in each protein .	parallel	1
720	10075656	2033;5468	p300;PPARgamma	We show here that the ***interaction*** between ***p300/CBP*** and ***PPARgamma*** is complex and involves multiple domains in each protein .	parallel	1
721	10075666	6667;356	Sp1;Fas ligand	Constitutive ***Fas ligand*** gene transcription in Sertoli cells is ***regulated*** by ***Sp1*** .	target	1
722	10075666	6667;356	Sp1;FasL	The data presented demonstrates that constitutive ***FasL*** gene transcription in Sertoli cells is ***regulated*** by ***Sp1*** .	target	1
723	10075666	6667;356	Sp1;FasL	In addition , it is shown that basal ***FasL*** expression in Jurkat T cells is also ***controlled*** by ***Sp1*** and this is in contrast to induced FasL expression , which is NFAT-dependent .	target	0
724	10075671	3572;3553	gp130;IL-1	However , in the absence of Box3 , ***gp130*** still stimulates the expression of alpha2-macroglobulin and ***synergizes*** with ***IL-1*** to up-regulate alpha1-acid glycoprotein .	parallel	0
725	10075690	8945;4792	betaTrCP;IkappaBalpha	Expression of a F-box-deleted ***betaTrCP*** ***inhibits*** ***IkappaBalpha*** degradation , promotes accumulation of phosphorylated Ser32-Ser36 IkappaBalpha , and prevents NF-kappaB-dependent transcription .	negative	1
726	10075690	8945;4792	betaTrCP;IkappaBalpha	Expression of a F-box-deleted ***betaTrCP*** inhibits IkappaBalpha degradation , ***promotes*** accumulation of phosphorylated Ser32-Ser36 ***IkappaBalpha*** , and prevents NF-kappaB-dependent transcription .	positive	0
727	10075695	8739;598	DP5;Bcl-xl	Moreover , ***DP5*** specifically ***interacts*** with ***Bcl-xl*** during neuronal apoptosis following exposure to A beta , and its binding could impair the survival-promoting activities of Bcl-xl .	parallel	1
728	10075695	8739;598	DP5;Bcl-xl	Thus , the induction of DP5 mRNA and the ***interaction*** of ***DP5*** and ***Bcl-xl*** could play significant roles in neuronal degeneration following exposure to A beta .	parallel	1
729	10075695	8739;598	DP5;Bcl-xl	The 30-kDa Bcl-xl was co-immunoprecipitated with Myc-tagged DP5 , suggesting that ***DP5*** physically ***interacts*** with ***Bcl-xl*** in mammalian cells .	parallel	1
730	10075695	598;8739	Bcl-xl;DP5	The 30-kDa ***Bcl-xl*** was ***co-immunoprecipitated*** with Myc-tagged ***DP5*** , suggesting that DP5 physically interacts with Bcl-xl in mammalian cells .	parallel	1
731	10075695	8739;598	DP5;Bcl-xl	Here , we analyzed DP5 gene expression and the specific ***interaction*** of ***DP5*** with ***Bcl-xl*** during neuronal death induced by amyloid-beta protein ( A beta ) .	parallel	1
732	10075696	8844;7453	KSR-1;gamma2	***KSR-1*** also ***interacted*** with ***gamma2*** and gamma3 in a two-hybrid assay .	parallel	1
733	10075698	7124;231	tumor necrosis factor-alpha;aldose reductase	Osmotic response element is required for the ***induction*** of ***aldose reductase*** by ***tumor necrosis factor-alpha*** .	target	1
734	10075705	8775;6804	alpha-SNAP;syntaxin 1A	We conclude that 1 ) alpha-SNAP plays a crucial role in insulin exocytosis via large dense core vesicles , but not GABA released via synaptic-like microvesicles , in pancreatic beta cells ; and 2 ) the ***interaction*** of ***alpha-SNAP*** and ***syntaxin 1A*** may play an important role in the insulin exocytotic process .	parallel	1
735	10075705	8775;6804	alpha-SNAP;syntaxin 1A	An in vitro binding study showed that both wild-type alpha-SNAP and C-terminal-deleted ***alpha-SNAP*** mutant ( 1-285 ) can ***bind*** to ***syntaxin 1A*** .	parallel	1
736	10075710	5464;2017	PP1;cortactin	***cortactin*** phosphorylation was triggered by shrinkage and not by changes in osmolarity or pHi and was ***abrogated*** by ***PP1*** .	negative	0
737	10075717	6469;2735	Sonic Hedgehog;Gli1	***Sonic Hedgehog-induced*** ***activation*** of the ***Gli1*** promoter is mediated by GLI3 .	positive	1
738	10075717	6469;2737	Shh;GLI3	The trans-activating capacity of ***GLI3*** is positively and negatively ***regulated*** by ***Shh*** and cAMP-dependent protein kinase , respectively , through a specific region of GLI3 , which contains the CBP-binding domain and the phosphorylation sites of cAMP-dependent protein kinase .	target	1
739	10075717	2737;2735	GLI3;Gli1	***GLI3*** directly ***binds*** to the ***Gli1*** promoter and induces Gli1 transcription in response to Shh .	parallel	1
740	10075717	2737;2735	GLI3;Gli1	***GLI3*** directly binds to the Gli1 promoter and ***induces*** ***Gli1*** transcription in response to Shh .	target	1
741	10075735	990;4998	CDC6;Orc1	To further investigate the molecular mechanism of nucleotide-binding function , we have demonstrated that the ***CDC6*** protein ***associates*** with ***Orc1*** in vitro and in vivo .	parallel	0
742	10075735	990;4998	CDC6;Orc1	Intriguingly , the ***interaction*** between ***Orc1*** and ***CDC6*** is disrupted when the CDC6 ( K114E ) protein is used .	parallel	1
743	10075735	990;4998	CDC6;Orc1	Our results suggest that a proper molecular ***interaction*** between ***Orc1*** and ***CDC6*** depends on the functional ATP-binding of CDC6 , which may be a prerequisite step to assemble the operational replicative complex at the G1/S transition .	parallel	1
744	10075736	4194;4193	MDMX;MDM2	The ***MDMX*** gene product is ***related*** to the ***MDM2*** oncoprotein , both of which interact with the p53 tumor suppressor .	parallel	0
745	10075736	4194;7157	MDMX;p53	This truncated ***MDMX*** protein is termed MDMX-S ( " short form " ) , represents only the p53-binding domain , and appears to ***bind*** ***p53*** better than full-length MDMX .	parallel	1
746	10075738	7041;367	ARA55;androgen receptor	Cloning and characterization of ***androgen receptor*** ***coactivator*** , ***ARA55*** , in human prostate .	positive	1
747	10075741	6714;1956	c-Src;epidermal growth factor receptor	***c-Src-mediated*** ***phosphorylation*** of the ***epidermal growth factor receptor*** on Tyr845 and Tyr1101 is associated with modulation of receptor function .	target	1
748	10075741	1956;6714	EGFR;c-Src	Accumulating evidence indicates that ***interactions*** between the epidermal growth factor receptor ( ***EGFR*** ) and the nonreceptor tyrosine kinase ***c-Src*** may contribute to an aggressive phenotype in multiple human tumors .	parallel	1
749	10075741	1956;6714	EGFR;c-Src	Here we provide evidence that ***association*** between ***c-Src*** and ***EGFR*** can occur directly , as shown by receptor overlay experiments , and that it results in the appearance of two novel tyrosine phosphorylations on the receptor that are seen both in vitro and in vivo following EGF stimulation .	parallel	0
750	10075741	6714;1956	c-Src;EGFR	Phosphorylation of Tyr416 and homologous residues in other tyrosine kinase receptors has been shown to be required for or to increase catalytic activity , suggesting that ***c-Src*** can ***influence*** ***EGFR*** activity by mediating phosphorylation of Tyr845 .	target	0
751	10075822	7187;5604	cRaf-1;MEK1	When the purified components are incubated together , ***cRaf-1*** phosphorylates and ***activates*** ***MEK1*** , MEK1 phosphorylates and activates ERK2 , and ERK2 phosphorylates the peptide , biotin-AAATGPLSPGPFA .	positive	1
752	10075822	5604;5594	MEK1;ERK2	When the purified components are incubated together , cRaf-1 phosphorylates and activates MEK1 , ***MEK1*** ***phosphorylates*** and activates ***ERK2*** , and ERK2 phosphorylates the peptide , biotin-AAATGPLSPGPFA .	target	1
753	10075854	10468;10220	follistatin;BMP-11	Interestingly , the activin antagonist , ***follistatin*** , but not noggin , an antagonist of BMPs 2 and 4 , ***inhibited*** ***BMP-11*** activity on animal caps .	negative	1
754	10075858	5599;3725	JNK;AP-1	We demonstrate that transcriptional activation of the human RANTES promoter by LPS is dependent on specific ***AP-1*** and NF-kappaB response elements , which are ***regulated*** by c-Jun N-terminal kinase ( ***JNK*** ) and NF-kappaB kinase cascades , respectively .	target	1
755	10075858	5599;4790	JNK;NF-kappaB	We demonstrate that transcriptional activation of the human RANTES promoter by LPS is dependent on specific AP-1 and ***NF-kappaB*** response elements , which are ***regulated*** by c-Jun N-terminal kinase ( ***JNK*** ) and NF-kappaB kinase cascades , respectively .	target	1
756	10075858	4790;3725	NF-kappaB;AP-1	We demonstrate that transcriptional activation of the human RANTES promoter by LPS is dependent on specific ***AP-1*** and NF-kappaB response elements , which are ***regulated*** by c-Jun N-terminal kinase ( JNK ) and ***NF-kappaB*** kinase cascades , respectively .	target	1
757	10075862	958;959	CD40;CD40L	We found that the inhibition of the ******CD40L-CD40****** ***interaction*** in GvH animals by the administration of an anti-CD40L antibody ( MR-1 ) completely prevents the development of crypt hyperplasia and villous atrophy in GvH animals .	parallel	1
758	10075862	958;959	CD40;CD40L	In conclusion , the ******CD40L-CD40****** ***interaction*** is crucial in the pathogenesis of T-cell-mediated mucosal atrophy .	parallel	1
759	10075921	1080;3301	CFTR;Hdj-2	Interestingly , complex ***formation*** between ***Hdj-2*** and nascent ***CFTR*** was greatly reduced after expression of the R-domain .	parallel	0
760	10075926	3716;3561	Jak1;gammac	For example , ***Jak1*** and Jak3 ***bind*** specifically to the IL-2 receptor beta ( IL-2Rbeta ) and common gamma ( ***gammac*** ) chains , respectively , and initiate biochemical signals critical in controlling immune responses .	parallel	1
761	10075926	3718;3561	Jak3;gammac	For example , Jak1 and ***Jak3*** ***bind*** specifically to the IL-2 receptor beta ( IL-2Rbeta ) and common gamma ( ***gammac*** ) chains , respectively , and initiate biochemical signals critical in controlling immune responses .	parallel	1
762	10075926	3716;3561	Jak1;gammac	Furthermore , a ***Jak3-Jak1*** chimera containing only the JH6 and JH7 domains of Jak3 ***interacts*** with ***gammac*** and can reconstitute IL-2-dependent responses , including receptor phosphorylation and activation of signal transducer and activator of transcription (STAT) 5b .	parallel	1
763	10075926	3718;3561	Jak3;gammac	Furthermore , a ***Jak3-Jak1*** chimera containing only the JH6 and JH7 domains of Jak3 ***interacts*** with ***gammac*** and can reconstitute IL-2-dependent responses , including receptor phosphorylation and activation of signal transducer and activator of transcription (STAT) 5b .	parallel	1
764	10075927	5599;1869	JNK1;E2F1	Here we report that two kinases involved in signal transduction have opposite effects on E2F function : the stress-induced kinase ***JNK1*** ***inhibits*** ***E2F1*** activity whereas the related p38 kinase reverses Rb-mediated repression of E2F1 .	negative	1
765	10075927	5599;1869	JNK1;E2F1	***JNK1*** ***phosphorylates*** ***E2F1*** in vitro , and co-transfection of JNK1 reduces the DNA binding activity of E2F1 ; treatment of cells with TNFalpha had a similar effect .	target	1
766	10075927	355;1432	Fas;p38	***Fas*** stimulation of Jurkat cells is known to ***induce*** ***p38*** kinase and we find a pronounced increase in Rb phosphorylation within 30 min of Fas stimulation .	target	1
767	10075936	4193;7157	MDM2;p53	Although the p53-binding protein ***MDM2*** has an NES and has been proposed to ***mediate*** ***p53*** export , we show that the intrinsic p53 NES is both necessary and sufficient for export .	target	0
768	10075937	8894;1983	eIF2;eIF5	We also find that three lysine-rich boxes in the N-terminal segment of eIF2beta mediate the ***binding*** of ***eIF2*** to both ***eIF5*** and eIF2B .	parallel	1
769	10075994	5989;5994	RFX;RFXAP	Our results suggest possible stoichiometry of the RFX subunits and potential ***interaction*** between ***RFX-B/Ank*** and ***RFXAP*** with one of the subunits of X2BP .	parallel	1
770	10075997	2547;7520	Ku70;Ku80	Electrophoretic mobility shift assays demonstrated that the ubiquitous factor that binds the -75 GATA sequence was the ******Ku70-Ku80****** ( Ku ) ***heterodimer*** .	parallel	1
771	10076053	3565;3976	Interleukin-4;leukemia inhibitory factor	***Interleukin-4*** ( IL-4 ) , but not IL-10 , ***regulates*** the synthesis of IL-6 , IL-8 and ***leukemia inhibitory factor*** by human bone marrow stromal cells .	target	1
772	10076189	4914;4803	Trk-A;NGF	Moreover , ***Trk-A*** , the nerve growth factor ( ***NGF*** ) high-affinity ***receptor*** , is expressed in vivo in mature rat islets and early during development in the pancreatic ductal network that represents the source of putative stem cells .	parallel	1
773	10076194	3569;7422	IL-6;VEGF	The endocrine and auto - / paracrine ***control*** of ***VEGF*** production in pituitary FS cells by PACAP , ***IL-6*** and glucocorticoids may play an important role both in angiogenesis and vascular permeability regulation within the pituitary under physiological and pathophysiological conditions .	target	0
774	10076194	116;7422	PACAP;VEGF	The endocrine and auto - / paracrine ***control*** of ***VEGF*** production in pituitary FS cells by ***PACAP*** , IL-6 and glucocorticoids may play an important role both in angiogenesis and vascular permeability regulation within the pituitary under physiological and pathophysiological conditions .	target	0
775	10076194	3569;7422	interleukin-6;vascular endothelial growth factor	Pituitary adenylate cyclase-activating polypeptide , ***interleukin-6*** and glucocorticoids ***regulate*** the release of ***vascular endothelial growth factor*** in pituitary folliculostellate cells .	target	1
776	10076194	116;7422	Pituitary adenylate cyclase-activating polypeptide;vascular endothelial growth factor	***Pituitary adenylate cyclase-activating polypeptide*** , interleukin-6 and glucocorticoids ***regulate*** the release of ***vascular endothelial growth factor*** in pituitary folliculostellate cells .	target	1
777	10076194	116;7422	Pituitary adenylate cyclase-activating polypeptide;VEGF	Interestingly , the ***VEGF*** secretion was ***stimulated*** by both forms of ***Pituitary adenylate cyclase-activating polypeptide*** ( PACAP-38 and PACAP-27 ) , indicating that this hypothalamic peptide regulates endothelial cell function and growth within the pituitary .	positive	0
778	10076194	3569;7422	interleukin-6;VEGF	***VEGF*** secretion was also ***stimulated*** by ***interleukin-6*** ( IL-6 ) whereas basal , IL-6 - and PACAP-stimulated secretion was inhibited by the synthetic glucocorticoid dexamethasone .	positive	0
779	10076538	3553;6647	IL-1 beta;Cu/Zn-superoxide dismutase	***IL-1 beta*** also ***increased*** cytosolic ***Cu/Zn-superoxide dismutase*** ( SOD ) and mitochondrial Mn-SOD in RINm5F cells .	positive	0
780	10076538	3553;6648	IL-1 beta;Mn-SOD	***IL-1 beta*** also ***increased*** cytosolic Cu/Zn-superoxide dismutase ( SOD ) and mitochondrial ***Mn-SOD*** in RINm5F cells .	positive	0
781	10076566	862;3320	MTG8;HSP90	***Association*** of ***MTG8*** ( ETO/CDR ) , a leukemia-related protein , with serine/threonine protein kinases and heat shock protein ***HSP90*** in human hematopoietic cell lines .	parallel	0
782	10076566	3320;862	HSP90;MTG8	In addition , we demonstrated that heat shock protein 90 ( ***HSP90*** ) specifically ***binds*** to the amino-terminal domain of ***MTG8*** in vitro and in vivo .	parallel	1
783	10076567	7157;1026	p53;WAF1	The ***p53-dependent*** ***induction*** of ***p21/WAF1*** and the following dephosphorylation of the retinoblastoma protein by CAV could account for the observed CAV-mediated G1 phase arrest .	target	1
784	10077002	7421;5741	vitamin D receptor;parathyroid hormone	Turning a negative into a positive : ***vitamin D receptor*** ***interactions*** with the avian ***parathyroid hormone*** response element .	positive	1
785	10077003	2247;885	bFGF;CCK	We conclude that ***bFGF*** and forskolin ***stimulate*** the ***CCK*** gene promoter via the CRE/TRE ( -80 ) in the proximal promoter region .	positive	0
786	10077051	5320;4843	PLA2;inducible NO synthase	***PLA2*** ( 50 ng/ml ) ***induced*** significant amounts of NO production , ***inducible NO synthase*** mRNA expression , and cytotoxicity toward the human umbilical vein endothelial cells in normal rat AMs , and these activities were significantly inhibited by quinacrine .	target	1
787	10077163	3458;6890	IFN-gamma;TAP1	***IFN-gamma*** ***up-regulates*** the expression of MHC-class-I antigens and ***TAP1*** both in control and in TAP1-transfected RCC cells to a similar level .	positive	1
788	10077343	3569;5741	IL-6;PTH	***IL-6*** levels ***correlated*** with ***PTH*** ( r = 0.22 , p = 0.04 ) and with ICTP ( r = 0.31 , p = 0.004 ) .	parallel	0
789	10077431	183;5154	angiotensin II;PDGF-A chain	***angiotensin II*** ***induced*** ***PDGF-A chain*** messenger RNA expression , and genistein inhibited angiotensin-induced PDGF gene expression .	target	1
790	10077561	1385;5371	CREB;PML	Here , we demonstrate that the cAMP enhancer binding protein ( ***CREB*** ) - binding protein ( CBP ) ***associates*** with ***PML*** in vitro and is recruited to the PODs in vivo .	parallel	0
791	10077576	10657;6714	Sam68;Src	***Sam68*** , the 68-kDa ***Src*** ***substrate*** associated during mitosis , is an RNA-binding protein with signaling properties that contains a GSG ( GRP33 , Sam68 , GLD-1 ) domain .	parallel	1
792	10077579	904;1025	cyclin T1;Cdk9	We found that P-TEFb complexes containing human ***cyclin T1*** ***complexed*** with either human or rodent ***Cdk9*** supported Tat transactivation and interacted with the Tat activation domain and the HIV-1 TAR RNA element to form TAR loop-dependent ribonucleoprotein complexes .	parallel	1
793	10077598	54521;8766	rab11BP;rab11	We have identified and cloned the cDNA for a 912-aa protein , ***rab11BP*** , that ***interacts*** with the GTP-containing active form of ***rab11*** , a GTP-binding protein that plays a critical role in receptor recycling .	parallel	1
794	10077598	8766;54521	rab11;rab11BP	In vitro ***binding*** of ***rab11*** to native ***rab11BP*** requires partial denaturation of the latter to expose an internal binding site located between residues 334 and 504 that is apparently masked by the C-terminal portion of the protein , which includes six repeats known as WD40 domains .	parallel	1
795	10077605	2737;5727	GLI3;PTCH1	Here we show that full-length ***GLI3*** localizes to the cytoplasm and ***activates*** ***PTCH1*** expression , which is similar to full-length Ci155 .	positive	1
796	10077605	2737;5727	GLI3;PTCH1	PHS mutant protein ( ***GLI3-PHS*** ) localizes to the nucleus and ***represses*** GLI3-activated ***PTCH1*** expression , which is similar to Ci75 .	negative	1
797	10077605	2737;5727	GLI3;PTCH1	The PAP-A mutant protein ( ***GLI3-PAP-A*** ) showed less specific subcellular localization but still ***inhibited*** GLI3-activated ***PTCH1*** transcription , suggesting it may be a weaker allele than the GLI3-PHS mutation .	negative	1
798	10077630	3383;3565	Intercellular adhesion molecule-1;interleukin 4	***Intercellular adhesion molecule-1*** ***inhibits*** ***interleukin 4*** production by naive T cells .	negative	1
799	10077630	3383;3565	ICAM-1;IL-4	However , coexpression of ***ICAM-1*** and B7 on Drosophila APC ***induced*** little ***IL-4*** , suggesting an inhibitory role for Intercellular adhesion molecule-1 ( ICAM-1 ) .	target	1
800	10077638	7422;8829	Vascular endothelial growth factor;neuropilin-1	***Vascular endothelial growth factor*** ( VEGF ) - like protein from orf virus NZ2 ***binds*** to VEGFR2 and ***neuropilin-1*** .	parallel	1
801	10077638	7422;3791	Vascular endothelial growth factor;VEGFR2	***Vascular endothelial growth factor*** ( VEGF ) - like protein from orf virus NZ2 ***binds*** to ***VEGFR2*** and neuropilin-1 .	parallel	1
802	10077639	4193;7157	Hdm2;p53	Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for ***Hdm2-mediated*** ***degradation*** of ***p53*** .	negative	1
803	10077639	4193;7157	Hdm2;p53	The ***Hdm2*** oncoprotein ***inhibits*** ***p53*** functions by two means : ( i ) it blocks p53 's transactivation activity and ( ii ) it targets p53 for degradation in a proteasome-dependent manner .	negative	1
804	10077639	4193;7157	Hdm2;p53	Recent data indicate that Hdm2 shuttles between the nucleus and the cytoplasm and that the ***regulation*** of ***p53*** levels by ***Hdm2*** requires its nuclear export activity .	target	1
805	10077639	4193;7157	Hdm2;p53	In the first , ***Hdm2*** ***binds*** to ***p53*** in the nucleus and shuttles p53 from the nucleus to the cytoplasm , and then it targets p53 to the cytoplasmic proteasome .	parallel	1
806	10077639	4193;7157	Hdm2;p53	Alternatively , Hdm2 and p53 could be exported separately from the nucleus and then associate in the cytoplasm , where ***Hdm2*** ***promotes*** the degradation of ***p53*** .	positive	0
807	10077639	4193;7157	Hdm2;p53	Hdm2NLS , Hdm2NES , or the combination of both mutants were unable to promote p53 degradation in the cotransfected 2KO cells ( which were null for both the p53 and mdm2 genes ) , although wild-type ***Hdm2*** efficiently ***reduced*** ***p53*** levels under the same conditions .	negative	1
808	10077642	1634;1956	decorin;epidermal growth factor receptor	This process is caused by a ***decorin-mediated*** ***activation*** of the ***epidermal growth factor receptor*** , which leads to a sustained induction of endogenous p21 ( WAF1/CIP1 ) ( the cyclin-dependent kinase inhibitor p21 ) and growth arrest .	positive	1
809	10077651	7037;7018	TfR;transferrin	We recently reported that HFE , the protein defective in HH , was physically associated with the ***transferrin*** ***receptor*** ( ***TfR*** ) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells , leading to up-regulation of transporters for dietary iron .	parallel	1
810	10077651	3077;7037	HFE;TfR	We recently reported that ***HFE*** , the protein defective in HH , was physically ***associated*** with the transferrin receptor ( ***TfR*** ) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells , leading to up-regulation of transporters for dietary iron .	parallel	0
811	10077665	375790;7402	agrin;utrophin	The ***modulation*** of ***utrophin*** gene expression in muscle by the nerve-derived factor ***agrin*** plausibly involves the trophic factor ARIA/heregulin .	target	0
812	10077697	4916;4908	TrkC;NT-3	In situ hybridization revealed that mRNA for the full-length ( catalytic ) ***NT-3*** ***receptor*** , ***TrkC*** , was present in , and limited to , the neural plate ( including the neural folds ) coincident with its formation .	parallel	1
813	10077990	5335;3558	PLC gamma 1;IL-2	Consequently , Ras/MAP kinase and ***PLC gamma 1*** pathways are activated to ***induce*** ***IL-2*** gene transcription through AP-1 and NF-AT generation .	target	1
814	10078198	5468;1050	PPAR gamma;C/EBP alpha	C/EBP alpha-deficient adipocytes accumulates less lipid , and they do not induce endogenous PPAR gamma , indicating that ***cross-regulation*** between ***C/EBP alpha*** and ***PPAR gamma*** is important in maintaining the differentiated state .	parallel	0
815	10078198	5468;1050	PPAR gamma;C/EBP alpha	These results define multiple roles for C/EBP alpha in adipogenesis and show that ***cross-regulation*** between ***PPAR gamma*** and ***C/EBP alpha*** is a key component of the transcriptional control of this cell lineage .	parallel	0
816	10078201	4193;7157	MDM2;p53	The binding of RB to MDM2 is shown to be essential for RB to overcome both the antiapoptotic function of MDM2 and the ***MDM2-dependent*** ***degradation*** of ***p53*** .	negative	1
817	10078201	4193;7157	MDM2;p53	The RB-MDM2 interaction does not prevent MDM2 from inhibiting p53-dependent transcription , but the ***RB-MDM2*** complex still ***binds*** to ***p53*** .	parallel	1
818	10078201	7157;4193	p53;MDM2	However , an ******RB-MDM2-p53****** trimeric ***complex*** is active in p53-mediated transrepression .	parallel	1
819	10078204	161882;2623	FOG;GATA-1	***FOG*** , a zinc finger protein , interacts with the amino ( N ) finger of GATA-1 and ***cooperates*** with ***GATA-1*** to promote differentiation .	parallel	0
820	10078204	161882;2623	FOG;GATA-1	Thus , ***interaction*** of ***FOG*** with ***GATA-1*** is essential for the function of GATA-1 in erythroid differentiation .	parallel	1
821	10078242	5340;5345	plasmin;alpha 2 plasmin inhibitor	The fibrinolytic system also became activated during LVAD treatment as was indicated by a marked increase in FDP-D-dimer and ******alpha 2 plasmin inhibitor-plasmin****** ***complex*** ( PIC ) .	parallel	1
822	10078535	867;7535	Cbl;ZAP-70	In T cells , ***Cbl-N*** ***binds*** to the tyrosine-phosphorylated inhibitory site of the protein tyrosine kinase ***ZAP-70*** .	parallel	1
823	10078551	2646;2645	glucokinase regulatory protein;glucokinase	This hitherto unknown new protein factor may have the function of a ***glucokinase regulatory protein*** in the pancreatic beta-cell , which may ***regulate*** ***glucokinase*** enzyme activity in a glucose-dependent manner .	target	1
824	100786	6750;7200	Somatostatin;thyrotropin releasing factor	***Somatostatin*** ***inhibits*** release of ***thyrotropin releasing factor*** from organ cultures of rat hypothalamus .	negative	1
825	100786	6750;7200	Somatostatin;thyrotropin releasing factor	***Somatostatin*** in concentrations of 10 ( -6 ) to 10 ( -8 ) M ***inhibited*** basal release of ***thyrotropin releasing factor*** in organ culture of rat hypothalamus .	negative	1
826	10079103	1436;1440	CSFR;G-CSF	Because ***G-CSF*** ***receptor*** ( ***G-CSFR*** ) - deficient mice do not have the expected neutrophilia after administration of human interleukin-8 ( IL-8 ) , we examined the effect of the loss of G-CSFR on IL-8-stimulated PMN function .	parallel	1
827	10079106	5606;5594	MKK3;p38	Although ***MKK3*** , MKK4 , and MKK6 all activated p38 MAPk in experimental models , only MKK3 was found to ***activate*** recombinant ***p38*** MAPk in LPS-treated neutrophils .	positive	1
828	10079106	6416;5594	MKK4;p38	Although MKK3 , ***MKK4*** , and MKK6 all activated p38 MAPk in experimental models , only MKK3 was found to ***activate*** recombinant ***p38*** MAPk in LPS-treated neutrophils .	positive	1
829	10079106	5608;5594	MKK6;p38	Although MKK3 , MKK4 , and ***MKK6*** all activated p38 MAPk in experimental models , only MKK3 was found to ***activate*** recombinant ***p38*** MAPk in LPS-treated neutrophils .	positive	1
830	10079106	5606;1432	MKK3;p38alpha	These findings support a pathway by which LPS stimulation of neutrophils results in activation of ***MKK3*** , which in turn ***activates*** ***p38alpha*** MAPk , ultimately regulating adhesion , NF-kappaB activation , enhanced gene expression of TNF-alpha , and regulation of TNF-alpha synthesis .	positive	1
831	10079115	335;351	apo;Abeta	These findings suggest that human ***apo*** E isoforms ***decrease*** Abeta aggregation or increase ***Abeta*** clearance relative to an environment in which mouse apo E or no apo E is present .	negative	0
832	10079137	5080;3859	PAX-6;K12	The paired box homeotic gene 6 ( ***PAX-6*** ) , which is involved in controlling eye development , ***stimulated*** the activity of keratin ***K12*** promoter .	positive	0
833	10079141	7124;6347	TNFalpha;MCP-1	Levels of aqueous IL-8 and ***MCP-1*** at 12 hr are ***regulated*** by ***TNFalpha*** , while levels at 24 hr are regulated by TNFalpha and IL-1 .	target	1
834	10079194	3921;6227	LBP/p40;S21	Ribosome-associated protein ***LBP/p40*** ***binds*** to ***S21*** protein of 40S ribosome : analysis using a yeast two-hybrid system .	parallel	1
835	10079200	7040;2662	TGF-beta1;BMP-3b	In contrast , ***TGF-beta1*** treatment , which suppresses ALPase activity , rapidly and completely ***inhibited*** gene expression of ***BMP-3b*** .	negative	1
836	10079231	4654;3516	MyoD;CBF1	Moreover , Notch-induced antagonism of ***MyoD*** ***requires*** ***CBF1*** suggesting that the CBF1-dependent pathway mediates a cell-type-specific block in the myogenic program .	target	0
837	10079269	1026;1017	p21;cdk2	These results suggest that : ( i ) within an emerging extension made up of peripherally located tumor cells , their high proliferative potential gradually wanes as their relative topographical position becomes more central in the expanding tumor ; ( ii ) peripherally located tumor cells maintain their proliferative potential by higher cyclin A-cdk2 complex activity ; and ( iii ) intermediate expression of ***p21/p27*** in the peripherally located cells ***promotes*** higher cyclin ***A-cdk2*** kinase activity , whereas high p21/p27 expression in nonneoplastic cells inhibits kinase activity .	positive	0
838	10080242	885;3359	CCK;5-HT3	In the IMB model , specificity of 5-HT3-DA2 interactions , and of ******5-HT3-CCK****** ( A ) ***interactions*** from previous studies , prompted investigation of CCK ( A ) - DA2 interactions ; there appeared to be none .	parallel	1
839	1008045	885;796	CCK;calcitonin	It is postulated that these pancreatic secretion changes are the result of the ***interplay*** of released ***CCK*** and ***calcitonin*** .	parallel	1
840	10080532	3596;6778	IL-13;STAT6	We propose a model in which stimulation of monocytes by IFN activates de novo synthesis of an inhibitory factor , possibly one or more members of the SOCS / SSI/CIS gene family , capable of suppressing ***activation*** of ***STAT6*** by IL-4 and ***IL-13*** .	positive	1
841	10080532	3565;6778	IL-4;STAT6	We propose a model in which stimulation of monocytes by IFN activates de novo synthesis of an inhibitory factor , possibly one or more members of the SOCS / SSI/CIS gene family , capable of suppressing ***activation*** of ***STAT6*** by ***IL-4*** and IL-13 .	positive	1
842	10080538	4486;4485	RON;MSP	AKT kinase is a component of a separate branch of the ***RON/PI3-K*** pathway that ***mediates*** the ***MSP*** anti-apoptotic effect on epithelial cells .	target	0
843	10080538	4485;4486	MSP;RON	Kinases involved in ******MSP/RON****** ***signaling*** .	parallel	0
844	10080538	4485;207	MSP;AKT	In addition to previously identified involvement of phosphatidylinositol 3-kinase ( PI3-K ) , JNK , and MAPK , we found that FAK , c-Src , and ***AKT*** are rapidly and transiently ***activated*** by ***MSP*** .	positive	1
845	10080538	4485;6714	MSP;c-Src	In addition to previously identified involvement of phosphatidylinositol 3-kinase ( PI3-K ) , JNK , and MAPK , we found that FAK , ***c-Src*** , and AKT are rapidly and transiently ***activated*** by ***MSP*** .	positive	1
846	10080538	4485;5747	MSP;FAK	In addition to previously identified involvement of phosphatidylinositol 3-kinase ( PI3-K ) , JNK , and MAPK , we found that ***FAK*** , c-Src , and AKT are rapidly and transiently ***activated*** by ***MSP*** .	positive	1
847	10080539	7124;8174	TNF-alpha;MAdCAM-1	***MAdCAM-1*** expression in these tissues was significantly ***enhanced*** , in a time-dependent manner , by systemic administration of ***TNF-alpha*** .	positive	0
848	10080539	7124;8174	TNF-alpha;MAdCAM-1	Taken together , these data demonstrate that ***TNF-alpha*** ***enhances*** surface expression of ***MAdCAM-1*** in intestinal and colonic tissues to the same extent in both wild-type and IL-10 k/o mice with no colonic inflammation , whereas IL-10 k/o mice with active colitis exhibited a profound up-regulation of MAdCAM-1 in the colon .	positive	0
849	10080542	2322;2885	Flt3;Grb2	Like the chimeric murine Flt3 , human ***Flt3*** undergoes autophosphorylation , ***associates*** with ***Grb2*** , and leads to tyrosine phosphorylation of Shc on ligand binding .	parallel	0
850	10080542	5781;2885	SHP-2;Grb2	***SHP-2*** does not associate with Flt3 , but ***binds*** directly to ***Grb2*** .	parallel	1
851	10080875	4790;5970	p50;p65	Involvement of NF-kappaB ******p50/p65****** ***heterodimer*** in activation of the human pro-interleukin-1beta gene at two subregions of the upstream enhancer element .	parallel	1
852	10080878	7124;4803	TNF-alpha;NGF	These observations indicate that the basal level of brain ***NGF*** can be ***influenced*** negatively or positively by local expression of ***TNF-alpha*** and that this cytokine , through dose-dependent regulation of NGF synthesis and release , may be involved in neurodegenerative events associated with aging .	negative	0
853	10080908	861;1050	AML1;C/EBPalpha	Thus , ***AML1/ETO*** can ***bind*** to the transcription factor ***C/EBPalpha*** , inhibit C/EBPalpha-dependent transcription , and block granulocytic differentiation .	parallel	1
854	10080908	862;1050	ETO;C/EBPalpha	Thus , ***AML1/ETO*** can ***bind*** to the transcription factor ***C/EBPalpha*** , inhibit C/EBPalpha-dependent transcription , and block granulocytic differentiation .	parallel	1
855	10080908	862;861	ETO;AML1	However , ***AML1/ETO*** can also ***synergize*** with the transcription factor ***AML1*** to enhance the activity of the M-CSF receptor promoter .	parallel	0
856	10080918	8600;4982	OPGL;osteoprotegerin	Osteoblasts/stromal cells express a new member of the TNF-ligand family " osteoclast differentiation factor ( ODF ) / ***osteoprotegerin*** ***ligand*** ( ***OPGL*** ) / TNF-related activation-induced cytokine ( TRANCE ) / receptor activator of NF-kB ligand ( RANKL ) " as a membrane associated factor .	parallel	1
857	10080918	4982;8600	osteoprotegerin;ODF	***osteoprotegerin*** ( OPG ) / osteoclastogenesis inhibitory factor ( OCIF ) / TNF receptor-like molecule 1 ( TR1 ) is a soluble decoy ***receptor*** for ***ODF/OPGL/TRANCE*** / RANKL .	parallel	1
858	10080923	3953;6774	leptin receptor;STAT3	Tyrosine ***phosphorylation*** of ***STAT3*** by leptin through ***leptin receptor*** in mouse metaphase 2 stage oocyte .	target	1
859	10080923	3952;6774	leptin;STAT3	Tyrosine ***phosphorylation*** of ***STAT3*** by ***leptin*** through leptin receptor in mouse metaphase 2 stage oocyte .	target	1
860	10080930	943;944	CD30;CD153	These results indicated a differential regulation of CD30 and CD153 expression in T cells , which may be relevant to immuno-regulatory role of the ******CD30-CD153****** ***interaction*** .	parallel	1
861	10080941	1499;999	beta-catenin;E-cadherin	We found that the ***binding*** of ***beta-catenin*** to Tcf4 , APC , or ***E-cadherin*** was mutually exclusive .	parallel	1
862	10080943	355;7157	Fas;p53	Here , we report that although ***Fas*** induction is closely ***linked*** to the expression of wild type ***p53*** , it is not correlated with JNK activation induced by apoptotic stimuli .	parallel	0
863	10080948	8027;958	signal transducing adaptor molecule;CD40	TRAF2 is a ***signal transducing adaptor molecule*** which ***binds*** to the ***CD40*** cytoplasmic domain .	parallel	1
864	10080949	3569;6774	IL-6;Stat3	Interestingly , a short pretreatment of cells with alpha-thrombin significantly inhibited ***IL-6-induced*** tyrosine ***phosphorylation*** of ***Stat3*** .	target	1
865	10080955	4286;7306	MITF;TRP-1	Microphthalmia transcription factor ***MITF*** , a melanocyte-specific basic helix-loop-helix protein , has been shown to ***transactivate*** Tyrosinase and ***TRP-1*** genes in vitro by binding to a shared regulatory sequence known as M box .	positive	1
866	10080955	4286;7299	MITF;Tyrosinase	Microphthalmia transcription factor ***MITF*** , a melanocyte-specific basic helix-loop-helix protein , has been shown to ***transactivate*** ***Tyrosinase*** and TRP-1 genes in vitro by binding to a shared regulatory sequence known as M box .	positive	1
867	10080957	4145;5829	Chk;paxillin	Using Far Western analysis , we revealed that the ***Chk*** SH2 domain directly ***associates*** with tyrosine phosphorylated ***paxillin*** .	parallel	0
868	10080957	2288;5829	p52;paxillin	Finally , ***p52*** ( Chk ) expression in Csk-deficient mouse embryo fibroblasts ***decreased*** total phosphotyrosine levels of ***paxillin*** , implying a physiological role for Chk .	negative	0
869	10080957	4145;5829	Csk homologous kinase;paxillin	The ***Csk homologous kinase*** , Chk , ***binds*** tyrosine phosphorylated ***paxillin*** in human blastic T cells .	parallel	1
870	10080957	4145;5829	Chk;paxillin	Interestingly , ***Chk*** specifically ***bound*** tyrosine phosphorylated ***paxillin*** .	parallel	1
871	10080957	4145;5829	Chk;paxillin	Using GST fusion proteins , we determined that the ***Chk*** SH2 domain , not the SH3 domain , ***bound*** tyrosine phosphorylated ***paxillin*** .	parallel	1
872	10081488	4363;4613	MRP;N-myc	We found a close ***association*** between ***MRP*** and ***N-myc*** expression in each neuroblastoma sample but no significant relationship between MRP expression and the patients ' outcome .	parallel	0
873	10081488	4613;4363	N-myc;MRP	The forced expression of ***N-myc*** failed to ***enhance*** the expression of ***MRP*** in N-myc transfected neuroblastoma cell lines .	positive	0
874	10081495	7039;1890	TGF-alpha;thymidine phosphorylase	EGF and ***TGF-alpha*** ***up-regulated*** ***thymidine phosphorylase*** ( dThdPase ) expression of tumor cells and consequently enhanced the antiproliferative action of 5 ' - dFUrd , which is converted to 5-fluorouracil by dThdPase .	positive	1
875	10081611	3572;3976	gp130;Leukemia inhibitory factor	Leukemia inhibitory factor action is mediated by a heterodimeric receptor consisting of two subunits , ***gp130*** and the low-affinity ***Leukemia inhibitory factor*** ***receptor*** ( LIFR ) .	parallel	1
876	10081611	3977;3976	LIFR;Leukemia inhibitory factor	Leukemia inhibitory factor action is mediated by a heterodimeric receptor consisting of two subunits , gp130 and the low-affinity ***Leukemia inhibitory factor*** ***receptor*** ( ***LIFR*** ) .	parallel	1
877	10081660	3486;3479	IGFBP-3;IGF-I	In a third series of experiments , ***IGFBP-3*** ***inhibited*** ***125I-IGF-I*** binding to granulosa cells .	negative	1
878	10082132	7039;1956	TGFalpha;EGFR	We recently reported that ***TGFalpha*** ***induces*** less efficient ***EGFR*** heterodimerization and downregulation than does EGF ( Gulliford et al. , 1997 , Oncogene , 15:2219 -2223 ) .	target	1
879	10082132	7039;1956	TGFalpha;EGFR	This suggests that BFA blocks EGFR recycling and thus shortens EGF-dependent receptor signalling , whereas ***TGFalpha*** shortens receptor signalling and thus ***blocks*** ***EGFR*** downregulation .	negative	0
880	10082137	3458;1277	IFN-gamma;COL1A1	The results indicate that ***IFN-gamma*** ***inhibits*** ***COL1A1*** expression in fibroblasts principally at the level of gene transcription .	negative	1
881	10082137	3458;1277	IFN-gamma;alpha1(I) procollagen	In this study , we examined the ***modulation*** of ***alpha1(I) procollagen*** gene ( COL1A1 ) expression by recombinant ***IFN-gamma*** .	target	0
882	10082137	3439;3458	IFN-alpha;IFN-gamma	IFN-alpha and IFN-beta by themselves had little effect on promoter activity , but ***IFN-alpha*** ***augmented*** the inhibitory effect of ***IFN-gamma*** .	positive	0
883	10082424	7124;4790	Tumor necrosis factor-alpha;NF-kappaB	***Tumor necrosis factor-alpha*** ( TNF ) induces apoptosis in confluent LLC-PK1 epithelial cells , but also ***activates*** ***NF-kappaB*** , a negative regulator of apoptosis .	positive	1
884	10082520	3303;5599	HSP72;JNK	Elevation of cellular levels of the major heat shock protein HSP72 inhibited a repression of JNK dephosphorylation by these stressful treatments , which explains recent reports of the ***suppression*** of ***JNK*** activation by ***HSP72*** .	negative	1
885	10082522	2796;1958	GnRH;Egr-1	We now show that ***GnRH*** is a potent ***stimulator*** of ***Egr-1*** , but not Ptx1 or SF-1 , expression .	positive	0
886	10082522	1958;2516	Egr-1;SF-1	***Egr-1*** ***interacts*** directly with Ptx1 and with ***SF-1*** , leading to an enhancement of Ptx1 - and SF-1-induced LHbeta transcription .	parallel	1
887	10082523	4654;4656	MyoD;myogenin	In vitro and in vivo assays revealed a direct ***association*** of Sp1 and ******myogenin-MyoD****** mediated by the DNA-binding domain of Sp1 and the HLH motif of myogenin .	parallel	0
888	10082523	4654;6667	MyoD;Sp1	In vitro and in vivo assays revealed a direct ***association*** of ***Sp1*** and ***myogenin-MyoD*** mediated by the DNA-binding domain of Sp1 and the HLH motif of myogenin .	parallel	0
889	10082523	6667;4656	Sp1;myogenin	In vitro and in vivo assays revealed a direct ***association*** of ***Sp1*** and ***myogenin-MyoD*** mediated by the DNA-binding domain of Sp1 and the HLH motif of myogenin .	parallel	0
890	10082528	2114;598	Ets2;bcl-x	The bcl-x promoter contains potential Ets binding sites , and we show that the transcription factor , ***Ets2*** , first identified by its sequence identity to v-ets of the E26 retrovirus , can ***transactivate*** the ***bcl-x*** promoter .	positive	1
891	10082535	4790;595	NF-kappaB;cyclin D1	***NF-kappaB*** was found to ***stimulate*** transcription of ***cyclin D1*** , a key regulator of G1 checkpoint control .	positive	0
892	10082537	4904;5813	YB-1;Puralpha	Reciprocal ***interaction*** between two cellular proteins , ***Puralpha*** and ***YB-1*** , modulates transcriptional activity of JCVCY in glial cells .	parallel	1
893	10082537	4904;5813	YB-1;Puralpha	Here we have examined the structural and functional ***interaction*** between two cellular regulatory proteins , ***YB-1*** and ***Puralpha*** , on the 23-bp sequence element derived from the enhancer-promoter of the human polyomavirus JCV .	parallel	1
894	10082537	4904;5813	YB-1;Puralpha	Affinity chromatography and coimmunoprecipitation provide evidence for a direct ***interaction*** between ***Puralpha*** and ***YB-1*** in the absence of the DNA sequence .	parallel	1
895	10082537	4904;5813	YB-1;Puralpha	The results of this study suggest that the cooperative ***interaction*** between ***YB-1*** and ***Puralpha*** mediates the synergistic activation of the human polyomavirus JCV genome by these cellular proteins .	parallel	1
896	10082538	6597;2353	BRG1;c-fos	Human SWI-SNF component ***BRG1*** ***represses*** transcription of the ***c-fos*** gene .	negative	1
897	10082538	6597;2353	BRG1;c-fos	***BRG1*** also specifically repressed transcription from a transfected c-fos promoter and correspondingly ***blocked*** transcriptional activation of the endogenous ***c-fos*** gene .	negative	0
898	10082545	9013;7343	SL1;UBF	A kinase activity associated with simian virus 40 large T antigen phosphorylates upstream binding factor ( UBF ) and promotes ***formation*** of a stable initiation complex between ***UBF*** and ***SL1*** .	parallel	0
899	10082545	7343;9013	UBF;SL1	Moreover , we showed that large T antigen-induced ***UBF*** phosphorylation ***promotes*** the formation of a stable ***UBF-SL1*** complex .	positive	0
900	10082545	9013;7343	SL1;UBF	Moreover , we showed that large T antigen-induced UBF phosphorylation promotes the formation of a stable ******UBF-SL1****** ***complex*** .	parallel	1
901	10082552	1022;2968	CAK;TFIIH	Recent reports have shown that Tat can also interact with the multisubunit transcription factor TFIIH complex and increase the phosphorylation of CTD by the Cdk-activating kinase ( ***CAK*** ) complex ***associated*** with the core ***TFIIH*** .	parallel	0
902	10082552	1022;2968	CAK;TFIIH	Therefore , unlike the P-TEFb kinase activity that is essential for Tat activation of HIV-1 transcriptional elongation , the ***CAK*** kinase ***associated*** with ***TFIIH*** appears to be dispensable for Tat function .	parallel	0
903	10082553	9013;7343	SL1;UBF	Alkaline phosphatase treatment of UBF completely abolished the ability of UBF to interact with SL1 ; moreover , incubation of the dephosphorylated UBF with nuclear extracts from exponentially growing cells was able to restore the ******UBF-SL1****** ***interaction*** .	parallel	1
904	10082553	7343;9013	UBF;SL1	Recruitment of TATA-binding protein-TAFI complex ***SL1*** to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor ( UBF ) and is ***regulated*** by ***UBF*** phosphorylation .	target	1
905	10082554	10260;4609	c-myc promoter binding protein;c-myc	We initially identified ***c-myc promoter binding protein*** 1 ( MBP-1 ) , which negatively ***regulates*** ***c-myc*** promoter activity , from a human cervical carcinoma cell expression library .	negative	1
906	10082561	1050;5933	C/EBPalpha;p107	Coimmunoprecipitation analyses revealed an ***interaction*** of ***C/EBPalpha*** with ***p107*** but none with cdk2 , E2F1 , or cyclin A.	parallel	1
907	10082561	1050;5933	C/EBPalpha;p107	***C/EBPalpha*** ***regulates*** formation of S-phase-specific ***E2F-p107*** complexes in livers of newborn mice .	target	1
908	10082562	7030;2113	TFE3;Ets-1	Both ***TFE3*** and USF ***enhanced*** ***Ets-1*** DNA binding in vitro by relieving the influence of an autoinhibitory domain in Ets-1 by direct protein-protein associations .	positive	0
909	10082566	836;5888	caspase 3;Rad51	In vitro studies show that ***Rad51*** is ***cleaved*** by ***caspase 3*** at a DVLD/N site .	target	1
910	10082572	4211;3205	MEIS1;HOXA9	***MEIS1*** ***enhances*** in vitro ***HOXA9-PBX*** protein complex formation in the absence of DNA and forms a trimeric electrophoretic mobility shift assay ( EMSA ) complex with these proteins on an oligonucleotide containing a PBX-HOXA9 site .	positive	0
911	10082572	4211;3205	MEIS1;HOXA9	Taken together , these data suggest that in myeloid leukemia cells ***MEIS1*** forms trimeric ***complexes*** with PBX and ***HOXA9*** , which in turn can bind to consensus PBX-HOXA9 DNA targets .	parallel	1
912	10082579	3667;5747	insulin receptor substrate 1;FAK	On the other hand , IGF-I promotes the ***association*** of ***insulin receptor substrate 1*** with the focal adhesion kinase ( ***FAK*** ) , paxillin , and the tyrosine phosphatase SHP-2 , resulting in FAK and paxillin dephosphorylation .	parallel	0
913	10082579	3667;5829	insulin receptor substrate 1;paxillin	On the other hand , IGF-I promotes the ***association*** of ***insulin receptor substrate 1*** with the focal adhesion kinase ( FAK ) , ***paxillin*** , and the tyrosine phosphatase SHP-2 , resulting in FAK and paxillin dephosphorylation .	parallel	0
914	10082579	3667;5781	insulin receptor substrate 1;SHP-2	On the other hand , IGF-I promotes the ***association*** of ***insulin receptor substrate 1*** with the focal adhesion kinase ( FAK ) , paxillin , and the tyrosine phosphatase ***SHP-2*** , resulting in FAK and paxillin dephosphorylation .	parallel	0
915	10082579	3479;3667	IGF-I;insulin receptor substrate 1	On the other hand , ***IGF-I*** ***promotes*** the association of ***insulin receptor substrate 1*** with the focal adhesion kinase ( FAK ) , paxillin , and the tyrosine phosphatase SHP-2 , resulting in FAK and paxillin dephosphorylation .	positive	0
916	10082583	983;4654	cdk1;MyoD	***MyoD*** can be efficiently ***phosphorylated*** in vitro by either purified cdk1-cyclin B or ***cdk1*** and cdk2 immunoprecipitated from proliferative myoblasts .	target	1
917	10082583	1017;4654	cdk2;MyoD	***MyoD*** can be efficiently ***phosphorylated*** in vitro by either purified cdk1-cyclin B or cdk1 and ***cdk2*** immunoprecipitated from proliferative myoblasts .	target	1
918	10082583	983;4654	cdk1;MyoD	Comparative two-dimensional tryptic phosphopeptide mapping combined with site-directed mutagenesis revealed that ***cdk1*** and cdk2 ***phosphorylate*** ***MyoD*** on serine 200 in proliferative myoblasts .	target	1
919	10082583	1017;4654	cdk2;MyoD	Comparative two-dimensional tryptic phosphopeptide mapping combined with site-directed mutagenesis revealed that cdk1 and ***cdk2*** ***phosphorylate*** ***MyoD*** on serine 200 in proliferative myoblasts .	target	1
920	10082587	5781;140885	SHP-2;SHPS-1	Previous studies revealed that a fraction of SHP-2 moves to focal contacts upon integrin engagement and that ***SHP-2*** ***binds*** to SHP substrate 1 ( ***SHPS-1*** ) / SIRP-1alpha , a transmembrane glycoprotein with adhesion molecule characteristics ( Y.	parallel	1
921	10082587	6714;140885	Src;SHPS-1	Both in vitro and in vivo studies indicate that ***SHPS-1*** tyrosyl phosphorylation is ***catalyzed*** by ***Src*** family protein tyrosine kinases ( PTKs ) .	positive	1
922	10082648	3329;25824	groEL;thioredoxin reductase	Fluorescence spectroscopy has been used to investigate the ***interaction*** of ***groEL*** and protein disulfide isomerase with denatured ***thioredoxin reductase*** tagged with a fluorescent probe .	parallel	1
923	10082656	7124;3383	TNF-alpha;ICAM-1	***TNF-alpha*** ***induced*** a transient ***ICAM-1*** increase in NHK , which reached peak-levels 2-4 days post cytokine stimulus .	target	1
924	10082658	6606;213	SMA;albumin	A comb-shaped polymeric modifier , ***SMA*** [ poly ( styrene comaleic anhydride ) ] , which ***binds*** to plasma ***albumin*** in blood was used to modify the synthetic cell-adhesive laminin peptide YIGSR , and its inhibitory effect on experimental lung metastasis of B16-BL6 melanoma cells was examined .	parallel	1
925	10082670	3553;1244	IL-1;MRP2	These results suggest that LPS activates Kupffer cells to secrete ***IL-1*** and TNFalpha , which in turn activate MAP kinases and ***decrease*** ***CMOAT/MRP2*** expression .	negative	0
926	10082809	1270;3977	CNTF;LIFR	***CNTF*** ***induced*** the tyrosine phosphorylation of ***LIFR*** and gp130 , as well as of proteins with the molecular weights of 88/91 and 42 kDa .	target	1
927	10082812	3479;2691	IGF-1;GHRH	The simultaneous inhibition of the somatotropic axis and sleep raises the possibility that the sleep alterations also result from an ***IGF-1-induced*** ***suppression*** of ***GHRH*** .	negative	1
928	10082837	9607;2353	CART;c-Fos	Recombinant ***CART*** peptide ***induces*** ***c-Fos*** expression in central areas involved in control of feeding behaviour .	target	1
929	10082837	9607;2353	CART;c-Fos	Compared to vehicle , ***CART*** ***induced*** ***c-Fos*** expression in several hypothalamic and brainstem structures implicated in the central control of food intake .	target	1
930	10082852	627;4852	BDNF;neuropeptide Y	Moreover , the specific ***BDNF*** increase was significantly ***correlated*** with contents of ***neuropeptide Y*** .	parallel	0
931	10082946	2006;1991	elastin;leukocyte elastase	***Interaction*** between ***leukocyte elastase*** and ***elastin*** : quantitative and catalytic analyses .	parallel	1
932	10082946	1991;2006	HLE;elastin	We now report quantitative measurements of the ***binding*** and catalytic interaction between ***HLE*** and ***elastin*** permitted by analogy to receptor-ligand systems .	parallel	1
933	10082946	1991;2006	HLE;elastin	Analysis of the ***binding*** of ***HLE*** to ***elastin*** at 0 degrees C , in the absence of significant catalytic activity , demonstrated two classes of binding sites ( Kd = 9.3 x10 ( -9 ) M and 2.5 x10 ( -7 ) M ) .	parallel	1
934	10082946	1991;2006	HLE;elastin	Our studies suggest that ***interaction*** of ***HLE*** with ***elastin*** in vivo may be very persistent and permit progressive solubilization of this structurally important extracellular matrix component .	parallel	1
935	10082949	7134;7138	TnC;TnT	Ca2 + regulation of vertebrate striated muscle contraction is initiated by conformational changes in the N-terminal , regulatory domain of the Ca2 + - binding protein troponin C ( TnC ) , altering the ***interaction*** of ***TnC*** with the other subunits of troponin complex , TnI and ***TnT*** .	parallel	1
936	10083623	3553;1906	Interleukin-1 beta;endothelin-1	***Interleukin-1 beta*** ***induces*** ***endothelin-1*** gene by multiple mechanisms .	target	1
937	10083766	2247;7422	bFGF;VEGF	By means of an enzyme-linked immunosorbent assay of CH-157MN meningioma cell supernatants , we demonstrated that EGF and ***bFGF*** similarly ***induce*** ***VEGF*** secretion by CH-157MN meningioma cells .	target	1
938	10084597	3952;3479	Leptin;IGF-I	These data demonstrate that ***Leptin*** can directly ***inhibit*** ***IGF-I*** action in ovarian theca and GC at concentrations commonly present in obese women .	negative	1
939	10084688	4684;1385	NCAM;CREB	***NCAM*** ***stimulates*** the Ras-MAPK pathway and ***CREB*** phosphorylation in neuronal cells .	positive	0
940	10084754	959;958	CD154;CD40	Central role for ***CD40/CD40*** ***ligand*** ( ***CD154*** ) interactions in transplant rejection .	parallel	1
941	10084754	959;958	CD154;CD40	Major advances have been made in understanding the expression and function of ***CD40*** and its ***ligand*** ***CD154*** .	parallel	1
942	10084754	958;959	CD40;CD154	It is now clear that ******CD40/CD154****** ***interactions*** are critical in many aspects of the immune response , including T cell activation , T cell-dependent macrophage activation , T cell-B cell interactions and endothelial activation .	parallel	1
943	10084754	958;959	CD40;CD154	Moreover , increasing evidence supports a central role for ******CD40/CD154****** ***interactions*** in the immune processes of allograft rejection .	parallel	1
944	10084951	356;355	FasL;Fas	The Fas ( APO-1 / CD95 ) receptor , a transmembrane protein that induces apoptosis in the cell when bound to ***Fas*** ***ligand*** ( ***FasL*** ) , may be involved .	parallel	1
945	10084962	5228;5601	PlGF;SAPK	Exogenous ***PlGF*** ***induced*** specific activation of the stress-activated protein kinase ( ***SAPK*** ) pathways , c-Jun-N terminal kinase ( JNK ) and p38 kinase , in primary term trophoblast with little to no induction of the extracellular signal regulated kinase ( ERK-1 and -2 ) pathways .	target	1
946	10084962	5228;5599	PlGF;JNK	Exogenous ***PlGF*** ***induced*** specific activation of the stress-activated protein kinase ( SAPK ) pathways , c-Jun-N terminal kinase ( ***JNK*** ) and p38 kinase , in primary term trophoblast with little to no induction of the extracellular signal regulated kinase ( ERK-1 and -2 ) pathways .	target	1
947	10084962	5228;1432	PlGF;p38	Exogenous ***PlGF*** ***induced*** specific activation of the stress-activated protein kinase ( SAPK ) pathways , c-Jun-N terminal kinase ( JNK ) and ***p38*** kinase , in primary term trophoblast with little to no induction of the extracellular signal regulated kinase ( ERK-1 and -2 ) pathways .	target	1
948	10084962	5228;5594	PlGF;ERK-1 and -2	In contrast , ***PlGF*** ***induced*** significant ***ERK-1 and -2*** activity in human umbilical vein endothelial cells but did not induce JNK or p38 activity .	target	1
949	10084962	5228;5601	PlGF;SAPK	***PlGF-induced*** ***activation*** of the ***SAPK*** signaling pathways protected trophoblast from growth factor withdrawal-induced apoptosis , but it did not protect trophoblast from apoptosis induced by the pro-inflammatory cytokines , interferon gamma and tumor necrosis factor alpha .	positive	1
950	10084970	2908;5743	Glucocorticoid receptor;prostaglandin endoperoxide synthase-2	***Glucocorticoid receptor-mediated*** post-ceramide ***inhibition*** of the interleukin-1beta-dependent induction of ovarian ***prostaglandin endoperoxide synthase-2*** in rats .	negative	1
951	10084996	3569;7422	interleukin-6;VEGF	Prevotella intermedia LPS , phorbol 12-myristate 13-acetate , and ***interleukin-6*** also ***induced*** ***VEGF*** mRNA expression in HPC .	target	1
952	10085038	959;958	CD40L;CD40	Because of the critical role of the ***CD40-CD40*** ***ligand*** ( ***CD40L*** ) pathway in the induction and effector phases of immune responses , we investigated the effects of CD40 ligation on the control of Trypanosoma cruzi infection .	parallel	1
953	10085062	10746;1147	MEKK2;IKK-alpha	We now show that ***MEKK2*** and MEKK3 can in vivo ***activate*** ***IKK-alpha*** and IKK-beta , induce site-specific IkappaBalpha phosphorylation , and , relatively modestly , activate an NF-kappaB reporter gene .	positive	1
954	10085062	10746;3551	MEKK2;IKK-beta	We now show that ***MEKK2*** and MEKK3 can in vivo ***activate*** IKK-alpha and ***IKK-beta*** , induce site-specific IkappaBalpha phosphorylation , and , relatively modestly , activate an NF-kappaB reporter gene .	positive	1
955	10085062	4215;1147	MEKK3;IKK-alpha	We now show that MEKK2 and ***MEKK3*** can in vivo ***activate*** ***IKK-alpha*** and IKK-beta , induce site-specific IkappaBalpha phosphorylation , and , relatively modestly , activate an NF-kappaB reporter gene .	positive	1
956	10085062	4215;3551	MEKK3;IKK-beta	We now show that MEKK2 and ***MEKK3*** can in vivo ***activate*** IKK-alpha and ***IKK-beta*** , induce site-specific IkappaBalpha phosphorylation , and , relatively modestly , activate an NF-kappaB reporter gene .	positive	1
957	10085062	10746;4790	MEKK2;NF-kappaB	We now show that ***MEKK2*** and MEKK3 can in vivo activate IKK-alpha and IKK-beta , induce site-specific IkappaBalpha phosphorylation , and , relatively modestly , ***activate*** an ***NF-kappaB*** reporter gene .	positive	1
958	10085062	10746;4792	MEKK2;IkappaBalpha	We now show that ***MEKK2*** and MEKK3 can in vivo activate IKK-alpha and IKK-beta , ***induce*** site-specific ***IkappaBalpha*** phosphorylation , and , relatively modestly , activate an NF-kappaB reporter gene .	target	1
959	10085065	718;727	C3a;C5a	The mutants were transiently expressed in HEK-293 cells ( with or without Galpha-16 ) and analyzed for cell surface expression , ***binding*** of ***C3a*** and ***C5a*** , and functional responsiveness ( calcium mobilization ) toward C3a , C5a , and a C3a as well as a C5a analogue peptide .	parallel	1
960	10085066	4193;7157	Mdm2;p53	In addition , ***Mdm2*** ***promotes*** ***p53*** degradation , thereby terminating its growth inhibitory signal .	positive	0
961	10085066	25;7157	c-Abl;p53	Recent studies have shown that the ***c-Abl*** protein-tyrosine kinase ***binds*** ***p53*** and enhances its transcriptional activity .	parallel	1
962	10085066	25;7157	c-Abl;p53	We demonstrate that ***c-Abl*** ***increases*** the expression level of the ***p53*** protein .	positive	0
963	10085066	4193;7157	Mdm2;p53	The enhanced expression is achieved by inhibiting ***Mdm2-mediated*** ***degradation*** of ***p53*** .	negative	1
964	10085083	387;6722	RhoA;serum response factor	***Activation*** of ***serum response factor*** by ***RhoA*** is mediated by the nuclear factor-kappaB and C/EBP transcription factors .	positive	1
965	10085083	387;4790	RhoA;NF-kappaB	Here , we demonstrate that ***activation*** of ***NF-kappaB*** by ***RhoA*** does not exclusively promote its nuclear translocation and binding to the specific kappaB sequences .	positive	1
966	10085083	4790;6722	NF-kappaB;serum response factor	***NF-kappaB*** is also involved in the ***regulation*** of the transcriptional activity of the c-fos ***serum response factor*** ( SRF ) , since the activation of a SRE-dependent promoter by RhoA can be efficiently interfered by the double mutant IkappaBalphaS32A/S36A , an inhibitor of the NF-kappaB activity .	target	1
967	10085083	4790;1051	p50;C/EBPbeta	We also present evidence that RelA and ***p50*** NF-kappaB subunits ***cooperate*** with the transcription factor ***C/EBPbeta*** in the transactivation of the 4 x SRE-CAT reporter .	parallel	0
968	10085083	5970;1051	RelA;C/EBPbeta	We also present evidence that ***RelA*** and p50 NF-kappaB subunits ***cooperate*** with the transcription factor ***C/EBPbeta*** in the transactivation of the 4 x SRE-CAT reporter .	parallel	0
969	10085083	387;1051	RhoA;C/EBPbeta	Furthermore , ***RhoA*** ***increases*** the levels of ***C/EBPbeta*** protein , facilitating the functional cooperation between NF-kappaB , C/EBPbeta , and SRF proteins .	positive	0
970	10085083	4790;1051	NF-kappaB;C/EBPbeta	Furthermore , RhoA increases the levels of C/EBPbeta protein , facilitating the functional ***cooperation*** between ***NF-kappaB*** , ***C/EBPbeta*** , and SRF proteins .	parallel	0
971	10085083	4790;6722	NF-kappaB;SRF	Furthermore , RhoA increases the levels of C/EBPbeta protein , facilitating the functional ***cooperation*** between ***NF-kappaB*** , C/EBPbeta , and ***SRF*** proteins .	parallel	0
972	10085083	6722;1051	SRF;C/EBPbeta	Furthermore , RhoA increases the levels of C/EBPbeta protein , facilitating the functional ***cooperation*** between NF-kappaB , ***C/EBPbeta*** , and ***SRF*** proteins .	parallel	0
973	10085086	4790;596	NFkappaB;Bcl-2	Expression of the mutant ***NFkappaB*** completely inhibited NFkappaB DNA binding activity and ***inhibited*** both TNF-induced up-regulation of ***Bcl-2*** and Bcl-x expression and neuroprotective effect .	negative	1
974	10085086	4790;598	NFkappaB;Bcl-x	Expression of the mutant ***NFkappaB*** completely inhibited NFkappaB DNA binding activity and ***inhibited*** both TNF-induced up-regulation of Bcl-2 and ***Bcl-x*** expression and neuroprotective effect .	negative	1
975	10085086	4790;596	NFkappaB;Bcl-2	These findings indicate that ***induction*** of ***Bcl-2*** and Bcl-x expression through ***NFkappaB*** activation is involved in the neuroprotective action of TNF against hypoxia - or nitric oxide-induced injury .	target	1
976	10085086	4790;598	NFkappaB;Bcl-x	These findings indicate that ***induction*** of Bcl-2 and ***Bcl-x*** expression through ***NFkappaB*** activation is involved in the neuroprotective action of TNF against hypoxia - or nitric oxide-induced injury .	target	1
977	10085098	2185;5599	RAFTK;JNK	These findings indicate that ***RAFTK-dependent*** ***induction*** of ***JNK*** in response to MMS is sensitive to Bcl-xL , but not to CrmA and p35 , by a mechanism that inhibits tyrosine phosphorylation and thereby activation of RAFTK .	target	1
978	10085098	598;2185	Bcl-xL;related adhesion focal tyrosine kinase	***Bcl-xL*** ***blocks*** activation of ***related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2*** and stress-activated protein kinase/c-Jun N-terminal protein kinase in the cellular response to methylmethane sulfonate .	negative	0
979	10085102	6892;6890	tapasin;TAP1	Like human tapasin , mouse ***tapasin*** ***binds*** both to ***TAP1/2*** and MHC class I.	parallel	1
980	10085102	6892;6890	tapasin;TAP1	In TAP2-mutated RMA-S cells , both TAP1 and MHC class I were coprecipitated by anti-tapasin antiserum indicative of ***association*** of ***tapasin*** with ***TAP1*** but not TAP2 .	parallel	0
981	10085109	6667;5409	Sp1;PNMT	Furthermore , ***activation*** of the ***PNMT*** promoter by ***Sp1*** depends on both its binding affinity for its cognate target sequences and its intracellular concentrations .	positive	1
982	10085109	6667;5409	Sp1;PNMT	Finally , another transcription factor expressed in the Neuro2A cells competes with Sp1 by interacting with DNA sequences 3 ' to the -48 base pair Sp1 site to prevent ***Sp1*** ***binding*** and induction of the ***PNMT*** promoter .	parallel	1
983	10085114	5911;5900	Rap2;RalGEF	When co-transfected in HeLa cells , an activated Rap2 mutant ( Rap2Val-12 ) but not an inactive protein ( Rap2Ala-35 ) co-immunoprecipitates with RalGDS and Rlf ; moreover , ******Rap2-RalGEF****** ***complexes*** can be isolated from the particulate fraction of transfected cells and were localized by confocal microscopy to the resident compartment of Rap2 , i.e. the endoplasmic reticulum .	parallel	1
984	10085115	1022;1017	CAK1;CDK2	***Phosphorylation*** of monomeric human ***CDK2*** by ***CAK1*** is more efficient than phosphorylation of the binary CDK2-cyclin A complex .	target	1
985	10085121	4214;4087	MEKK-1;Smad2	***Activation*** of ***Smad2*** by active ***MEKK-1*** results in enhanced Smad2-Smad4 interactions , nuclear localization of Smad2 and Smad4 , and the stimulation of Smad protein-transcriptional coactivator interactions in endothelial cells .	positive	1
986	10085121	4087;4089	Smad2;Smad4	Activation of Smad2 by active MEKK-1 results in enhanced ******Smad2-Smad4****** ***interactions*** , nuclear localization of Smad2 and Smad4 , and the stimulation of Smad protein-transcriptional coactivator interactions in endothelial cells .	parallel	1
987	10085121	4214;4087	MEKK-1;Smad2	Overexpression of Smad7 can inhibit the ***MEKK-1-mediated*** ***stimulation*** of ***Smad2*** transcriptional activity .	positive	0
988	10085125	4023;4043	lipoprotein lipase;RAP	We have investigated if ***lipoprotein lipase*** ***interacts*** with the ***RAP*** binding but structurally distinct receptor sortilin/neurotensin receptor-3 .	parallel	1
989	10085129	156;857	GRK2;caveolin-1	Based on the identification of a consensus caveolin binding motif within the pleckstrin homology domain of GRK2 , we tested the direct ***binding*** of purified full-length ***GRK2*** to various glutathione ***S-transferase-caveolin-1*** fusion proteins , and we discovered a specific interaction of GRK2 with the caveolin scaffolding domain .	parallel	1
990	10085131	6352;1234	RANTES;CCR5	***Aminooxypentane-RANTES*** profoundly ***induced*** ***CCR5*** phosphorylation , but had no effect on CCR1 .	target	1
991	10085134	2064;2885	ErbB2;GRB2	In contrast , EGFR truncation did not impair EGF mitogenic signaling , and in c ' 1000 cells EGF was able to stimulate the ***association*** of ***ErbB2*** with ***GRB2*** and SHC .	parallel	0
992	10085134	2064;6464	ErbB2;SHC	In contrast , EGFR truncation did not impair EGF mitogenic signaling , and in c ' 1000 cells EGF was able to stimulate the ***association*** of ***ErbB2*** with GRB2 and ***SHC*** .	parallel	0
993	10085136	5747;2185	FAK;CADTK	In contrast , ***FAK*** carboxyl terminus overexpression ***inhibited*** both FAK and ***CADTK*** autophosphorylation , suggesting that a FAK-dependent cytoskeletal function may be necessary for CADTK activation .	negative	1
994	10085136	2185;5747	CADTK;FAK	Biochemical experiments confirmed direct ***CADTK*** ***phosphorylation*** of ***FAK*** .	target	1
995	10085140	4088;1386	Smad3;ATF-2	The ***binding*** between ***ATF-2*** and ***Smad3/4*** is mediated via the MH1 region of the Smad proteins and the basic leucine zipper region of ATF-2 .	parallel	1
996	10085140	7040;1386	TGF-beta;ATF-2	***TGF-beta*** signaling also ***induces*** the phosphorylation of ***ATF-2*** via TAK1 and p38 .	target	1
997	10085143	5054;5270	PAI-1;PN-1	We have analyzed the ***binding*** of RAP , ***uPA.PAI-1*** , and ***uPA.PN-1*** to two naturally occurring VLDLR variants , VLDLR-I , containing all eight complement-type repeats , and VLDLR-III , lacking the third complement-type repeat , encoded by exon 4 .	parallel	1
998	10085143	5054;4043	PAI-1;RAP	We have analyzed the ***binding*** of ***RAP*** , ***uPA.PAI-1*** , and uPA.PN-1 to two naturally occurring VLDLR variants , VLDLR-I , containing all eight complement-type repeats , and VLDLR-III , lacking the third complement-type repeat , encoded by exon 4 .	parallel	1
999	10085143	4043;5270	RAP;PN-1	We have analyzed the ***binding*** of ***RAP*** , uPA.PAI-1 , and ***uPA.PN-1*** to two naturally occurring VLDLR variants , VLDLR-I , containing all eight complement-type repeats , and VLDLR-III , lacking the third complement-type repeat , encoded by exon 4 .	parallel	1
1000	10085143	5270;4043	PN-1;RAP	Surprisingly , ***uPA.PN-1*** , but not uPA.PAI-1 , ***competed*** ***RAP*** binding to both VLDLR variants .	negative	0
1001	10085149	1387;3172	CBP;HNF-4	These findings demonstrate that ***CBP*** acts as a transcriptional ***coactivator*** for ***HNF-4*** and provide new insights into the regulatory function of HNF-4 .	positive	1
1002	10085149	3172;1387	HNF-4;CBP	***HNF-4*** ***interacts*** with the N-terminal region of ***CBP*** ( amino acids 1-771 ) and the C-terminal region of CBP ( amino acids 1812-2441 ) .	parallel	1
1003	10085149	1387;3172	CBP;HNF-4	In addition , we show that in contrast to the other nuclear hormone receptors the ***interaction*** between ***HNF-4*** and ***CBP*** is ligand-independent .	parallel	1
1004	10085149	3172;1387	HNF-4;CBP	***Recruitment*** of ***CBP*** by ***HNF-4*** results in an enhancement of the transcriptional activity of the latter .	target	0
1005	10085149	3172;1387	HNF-4;CBP	CBP does not activate gene expression in the absence of HNF-4 , and dominant negative forms of HNF-4 prevent transcriptional activation by CBP , suggesting that the mere ***recruitment*** of ***CBP*** by ***HNF-4*** is not sufficient for enhancement of gene expression .	target	0
1006	10085150	3077;7037	HFE;TfR	At the cell surface , ***HFE*** ***complexes*** with transferrin receptor ( ***TfR*** ) , increasing the dissociation constant of transferrin ( Tf ) for its receptor 10-fold ( Gross , C.	parallel	1
1007	10085150	7037;7018	TfR;transferrin	At the cell surface , HFE complexes with ***transferrin*** ***receptor*** ( ***TfR*** ) , increasing the dissociation constant of transferrin ( Tf ) for its receptor 10-fold ( Gross , C.	parallel	1
1008	10085237	468;1649	ATF4;Gadd153	We further demonstrated that ***ATF4*** ***activates*** , while ATF3 represses , ***Gadd153*** promoter activity through the C/EBP-ATF site .	positive	1
1009	10085237	468;1649	ATF4;Gadd153	ATF3 also repressed ***ATF4-mediated*** ***transactivation*** and arsenite-induced activation of the ***Gadd153*** promoter .	positive	1
1010	10085252	7040;387	transforming growth factor beta-1;RhoA	Furthermore , ***transforming growth factor beta-1*** ***upregulates*** considerably the levels of the RhoB small GTPase and less the ***RhoA*** levels .	positive	1
1011	10085252	7040;388	transforming growth factor beta-1;RhoB	Furthermore , ***transforming growth factor beta-1*** ***upregulates*** considerably the levels of the ***RhoB*** small GTPase and less the RhoA levels .	positive	1
1012	10085258	999;1499	E-cadherin;beta-catenin	***E-cadherin*** binding ***prevents*** beta-catenin nuclear localization and ***beta-catenin/LEF*** -1 - mediated transactivation .	negative	0
1013	10085258	999;1499	E-cadherin;beta-catenin	Using recombinant proteins , we found that E-cadherin and lymphocyte-enhancer factor-1 ( LEF-1 ) form mutually exclusive complexes with beta-catenin ; the association of ***beta-catenin*** with LEF-1 was ***competed*** out by the ***E-cadherin*** cytoplasmic domain .	negative	0
1014	10085289	637;581	Bid;Bax	Using isolated mitochondria and various BH3 mutants of Bid , we demonstrate that direct ***binding*** of ***Bid*** to ***Bax*** is a prerequisite for Bax structural change and cytochrome c release .	parallel	1
1015	10085289	598;637	Bcl-xL;Bid	***Bcl-xL*** can ***inhibit*** the effect of ***Bid*** by interacting directly with Bax .	negative	1
1016	10085289	637;581	Bid;Bax	Taken together , our results suggest that , during certain types of apoptosis , ***Bid*** translocates to mitochondria and ***binds*** to ***Bax*** , leading to a change in conformation of Bax and to cytochrome c release from mitochondria .	parallel	1
1017	10085291	596;836	Bcl-2;procaspase-3	Activation of membrane-associated ***procaspase-3*** is ***regulated*** by ***Bcl-2*** .	target	1
1018	10085297	4301;10580	l-afadin;Ponsin	The third proline-rich region of ***l-afadin*** ***bound*** to the region of ***Ponsin*** containing the second and third SH3 domains .	parallel	1
1019	10085298	5829;5782	paxillin;PTP-PEST	This phenomenon appears to be due in part to a constitutive increase in tyrosine phosphorylation of p130 ( CAS ) , a known PTP-PEST substrate , ***paxillin*** , which ***associates*** with ***PTP-PEST*** in vitro , and focal adhesion kinase ( FAK ) .	parallel	0
1020	10085298	5829;5782	paxillin;PTP-PEST	This phenomenon appears to be due in part to a constitutive increase in tyrosine phosphorylation of p130 ( CAS ) , a known ***PTP-PEST*** ***substrate*** , ***paxillin*** , which associates with PTP-PEST in vitro , and focal adhesion kinase ( FAK ) .	parallel	1
1021	10085405	958;959	CD40;CD154	******CD40-CD154****** ***interaction*** in experimental and human disease ( review ) .	parallel	1
1022	10085405	959;958	CD154;CD40	It has clearly emerged that among these signals few cell surface receptor-ligand pairs , such as ***CD40*** and its ***ligand*** , ***CD154*** , are mandatory for the induction of lymphocyte activation .	parallel	1
1023	10085405	958;959	CD40;CD154	Indeed , various approaches aimed to disrupt natural ******CD40-CD154****** ***interaction*** were highly effective in the prevention and treatment of several experimental models of autoimmune disease and transplant rejection .	parallel	1
1024	10085415	5970;4790	p65;p50	Supershift assays for the NF-kappaB region showed that there are ******p50-p65****** ***heterodimers*** and p50 homodimers in the nuclear extracts of the two types of B cells , while those from tumor bearers lack the c-Rel component that is present in normal B cells .	parallel	1
1025	10085445	3565;3586	Interleukin-4;interleukin-10	***Interleukin-4*** ***cooperates*** with ***interleukin-10*** to inhibit vascular permeability factor release by peripheral blood mononuclear cells from patients with minimal-change nephrotic syndrome .	parallel	0
1026	10085445	3565;7422	Interleukin-4;vascular permeability factor	***Interleukin-4*** cooperates with interleukin-10 to ***inhibit*** ***vascular permeability factor*** release by peripheral blood mononuclear cells from patients with minimal-change nephrotic syndrome .	negative	1
1027	10085445	3565;7422	IL-4;VPF	These data demonstrate that ***IL-4*** acts in concert with IL-10 to ***inhibit*** ***VPF*** release and suggest that they are effective biologic regulators of the VPF responses in vitro .	negative	1
1028	10085539	1756;1605	dystrophin;beta-dystroglycan	It has been biochemically shown that ***dystrophin*** and alpha - and ***beta-dystroglycan*** form an oligomeric ***complex*** which links laminin , a component of the basement membrane , to components of the subsarcolemmal cytoskeleton in skeletal muscle fibers .	parallel	1
1029	10086274	4914;4803	TrkA;nerve growth factor	The recent advances in neuroblastoma research have revealed that the neurotrophin signals , especially those through ***nerve growth factor*** and its ***receptor*** , ***TrkA*** , play an important role in regulating the regression of neuroblastoma .	parallel	1
1030	10086320	3312;10049	Hsc70;DnaJ	Because Hsc70s represent a diverse group of cellular effectors and because ***Hsc70*** function frequently ***requires*** a ***DnaJ*** molecular chaperone , the specificity of DSG for different Hsc70s and the ability of DSG to block the productive interaction between an Hsc70 and its DnaJ partner were examined .	target	0
1031	10086322	213;3700	albumin;gp120	In the present study , we described the ***interaction*** of succinylated human serum ***albumin*** ( Suc-HSA ) , a negatively charged anti-HIV-1 active protein , with HIV-1 ***gp120*** and in detail with the third variable domain of gp120 ( V3 loop ) .	parallel	1
1032	10086332	596;835	Bcl-2;caspase-2	***Bcl-2*** ***regulates*** a ***caspase-3/caspase-2*** apoptotic cascade in cytosolic extracts .	target	1
1033	10086332	596;836	Bcl-2;caspase-3	***Bcl-2*** ***regulates*** a ***caspase-3/caspase-2*** apoptotic cascade in cytosolic extracts .	target	1
1034	10086338	7040;1294	TGF-beta;COL7A1	We have previously demonstrated that transforming growth factor-beta ( ***TGF-beta*** ) and pro-inflammatory cytokines , such as tumor necrosis factor-alpha ( TNF-alpha ) or interleukin-1beta , synergistically ***enhance*** the expression of type VII collagen gene ( ***COL7A1*** ) in human dermal fibroblasts in culture ( Mauviel et al. , 1994 ) .	positive	0
1035	10086338	4790;7124	NF-kappaB;TNF-alpha	In particular , we demonstrate that the ***TNF-alpha*** effect is ***mediated*** by NF-kappaB1 / RelA ( p50/p65 ) and RelA/RelA ( p65/p65 ) ***NF-kappaB*** complexes binding the TNF-alpha response element ( TaRE ) located in the region [ -252 / -230 ] , with RelA acting as the transcriptional activator .	target	0
1036	10086338	5970;7124	p65;TNF-alpha	In particular , we demonstrate that the ***TNF-alpha*** effect is ***mediated*** by NF-kappaB1 / RelA ( p50/p65 ) and RelA/RelA ( ***p65/p65*** ) NF-kappaB complexes binding the TNF-alpha response element ( TaRE ) located in the region [ -252 / -230 ] , with RelA acting as the transcriptional activator .	target	0
1037	10086339	9133;983	cyclin B2;p34cdc2	***cyclin B2*** is a ***regulator*** of ***p34cdc2*** kinase , involved in G2/M progression of the cell cycle , whose gene is strictly regulated at the transcriptional level in cycling cells .	target	1
1038	10086340	868;1956	cbl-b;epidermal growth factor receptor	***cbl-b*** ***inhibits*** ***epidermal growth factor receptor*** signaling .	negative	1
1039	10086382	2064;367	HER-2/neu;androgen receptor	A mechanism for hormone-independent prostate cancer through ***modulation*** of ***androgen receptor*** signaling by the ***HER-2/neu*** tyrosine kinase .	target	0
1040	10086382	2064;367	HER-2/neu;androgen receptor	***HER-2/neu*** ***activated*** the ***androgen receptor*** pathway in the absence of ligand and synergized with low levels of androgen to ' superactivate ' the pathway .	positive	1
1041	10086384	356;355	CD95 ligand;Fas	***Fas*** ***ligand*** ( ***CD95 ligand*** ) controls angiogenesis beneath the retina .	parallel	1
1042	10086384	355;356	Fas;FasL	We found that cultured choroidal endothelial cells were induced to undergo apoptosis by retinal pigment epithelial cells through a ******Fas-FasL****** ***interaction*** .	parallel	1
1043	10086725	861;7040	AML1;TGF-beta1	Furthermore , we show that whereas the expression of the fusion protein ***AML1/MDS1/EVI1*** completely ***abrogates*** the growth-inhibitory effect of ***TGF-beta1*** and allows 32Dcl3 cells to proliferate , expression of the normal protein MDS1/EVI1 has the opposite effect , and it strengthens the response of cells to the growth-inhibitory effect of TGF-beta1 .	negative	0
1044	10086725	861;4088	EVI1;SMAD3	By using the yeast two-hybrid system , we also show that ***EVI1*** ( contained in its entirety in MDS1/EVI1 and AML1/MDS1/EVI1 ) physically ***interacts*** with ***SMAD3*** , which is an intracellular mediator of TGF-beta1 signaling .	parallel	1
1045	10086725	861;7040	EVI1;TGF-beta1	***MDS1/EVI1*** ***enhances*** ***TGF-beta1*** signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/MDS1/EVI1 , product of the t ( 3 ; 21 ) , abrogates growth-inhibition in response to TGF-beta1 .	positive	0
1046	10086739	3569;598	IL-6;Bcl-X	We also found that ***IL-6*** but not IFN-alpha ***up-regulates*** ***Bcl-X*** ( L ) expression .	positive	1
1047	10086856	3458;3600	IFN-gamma;IL-15	***IFN-gamma*** ( 200 and 400 U/ml ) slightly ***increased*** the ***IL-15*** message level in a squamous cell carcinoma cell line , HSC-5 , in a dose-dependent fashion , whereas no significant change was observed in cultured normal human keratinocytes .	positive	0
1048	10086975	7133;7124	TNF-R1/R2;TNF-alpha	To determine this , we studied the expression and protein localization of ***TNF-alpha*** and its 2 main ***receptors*** ( ***TNF-R1/R2*** ) in a rat model of large infarction .	parallel	1
1049	10086980	3949;348	LDL receptor;apolipoprotein E	We demonstrated earlier that small ***apolipoprotein E*** ( apoE ) - exposing liposomes were specifically ***recognized*** by the ***LDL receptor*** .	target	1
1050	10087073	6469;3670	Shh;Islet-1	Moreover , ***Shh*** did ***induce*** ***Islet-1*** expression in neural tube explants , suggesting that it acts in combination with neural tube factors to induce motoneurons .	target	1
1051	10087073	6469;3670	Shh;Islet-1	However , the combination of N-terminal ***Shh*** and NT3 ***induced*** ***Islet-1*** expression in the majority of neurons in low-density cultures of caudal intermediate neural plate .	target	1
1052	10087091	3553;2353	IL-1beta;c-fos	Intraperitoneal ***IL-1beta*** also ***induces*** expression of the activation marker ***c-fos*** in vagal primary afferent neurons , suggesting that IL-1beta is a key component of vagally mediated immune-to-brain communication .	target	1
1053	10087180	3384;3683	CD102;CD11a	To account for the different effects of CD11a and CD54 blockade in vivo , an additional ***CD11a/CD18*** ***ligand*** , ***CD102*** ( ICAM-2 ) , was demonstrated on tumor-associated macrophages but not on tumor cells .	parallel	1
1054	10087182	3458;3717	IFN-gamma;Jak2	Immunoprecipitation and Western blot analyses indicated that ***IFN-gamma-induced*** ***phosphorylation*** of Stat1 and ***Jak2*** was blocked by dextran sulfate .	target	1
1055	10087182	3458;6772	IFN-gamma;Stat1	Immunoprecipitation and Western blot analyses indicated that ***IFN-gamma-induced*** ***phosphorylation*** of ***Stat1*** and Jak2 was blocked by dextran sulfate .	target	1
1056	10087267	55740;51466	Ena;Evl	Hence VASP / ******Ena/Evl****** ***link*** the bacterium to the actin tail , which is required for movement .	parallel	0
1057	10087335	2057;2056	EpoR;Erythropoietin	Recent investigations have shown that the glycoprotein ***Erythropoietin*** ( Epo ) and its specific ***receptor*** ( ***EpoR*** ) are present in the mammalian brain including human , monkey and mouse .	parallel	1
1058	10087446	3952;5367	leptin;MCH	It may also indicate that MCH mediates the metabolic actions of leptin indirectly or else that ***leptin*** ***influences*** actions of ***MCH*** other than those related to the regulation of energy balance .	target	0
1059	10087446	5367;3952	MCH;leptin	It may also indicate that ***MCH*** ***mediates*** the metabolic actions of ***leptin*** indirectly or else that leptin influences actions of MCH other than those related to the regulation of energy balance .	target	0
1060	10087612	7456;8976	WIP;NWASP	In this review , the authors discuss the possible role of WASP/NWASP and of the newly described protein ***WIP*** , which ***interacts*** with WASP and ***NWASP*** , in coupling signals from the T-cell receptor to the actin-based cytoskeleton .	parallel	1
1061	10087612	7456;7454	WIP;WASP	In this review , the authors discuss the possible role of WASP/NWASP and of the newly described protein ***WIP*** , which ***interacts*** with ***WASP*** and NWASP , in coupling signals from the T-cell receptor to the actin-based cytoskeleton .	parallel	1
1062	10087648	3439;4760	IFN-alpha;beta 2	Whereas IL-4 appears to repress functional IL-12 signaling through inhibition of IL-12R beta 2 expression , IFN-gamma in the mouse , and ***IFN-alpha*** in the human appear to ***induce*** IL-12R ***beta 2*** expression and promote IL-12 responsiveness .	target	1
1063	10087648	3458;4760	IFN-gamma;beta 2	Whereas IL-4 appears to repress functional IL-12 signaling through inhibition of IL-12R beta 2 expression , ***IFN-gamma*** in the mouse , and IFN-alpha in the human appear to ***induce*** IL-12R ***beta 2*** expression and promote IL-12 responsiveness .	target	1
1064	10087648	3439;6775	IFN-alpha;Stat4	In the human , this may also occur via ***IFN-alpha*** , which is able to ***activate*** ***Stat4*** .	positive	1
1065	10087648	6775;51497	Stat4;Th1	It is perhaps possible that all of Stat4 actions on Th1 development may be exert directly by Stat4 at the IFN-gamma gene , however we suggest that , more likely , ***Stat4*** may act to ***induce*** ***Th1*** development through the induction of other non-cytokine genes , whose stable expression maintains the transcriptional state of a Th1 cell .	target	1
1066	10087872	3567;3082	IL-5;HGF	It was also shown that ***IL-5*** ***induced*** the production of ***HGF*** by peripheral eosinophiles in vitro .	target	1
1067	10088202	5972;183	renin;angiotensin II	Furthermore , ***angiotensin II*** formation was believed to be ***regulated*** by ***renin*** secreted from the kidneys .	target	1
1068	10088603	1437;6892	Granulocyte-macrophage colony-stimulating factor;tapasin	***Granulocyte-macrophage colony-stimulating factor*** ***modulates*** ***tapasin*** expression in human neutrophils .	target	0
1069	10088610	729230;6347	CCR2;MCP-1	The CC-chemokine monocyte chemoattractant protein-1 ( ***MCP-1*** ) and its specific ***receptor*** ***CCR2*** are essential in monocytic infiltration and have been associated with several inflammatory diseases .	parallel	1
1070	10088650	3484;3479	IGF binding protein-1;IGF-I	In transgenic ( Tg ) mice , IGF-I overexpression stimulates postnatal brain growth , whereas decreased IGF-I availability caused by ectopic brain expression of ***IGF binding protein-1*** [ ( IGFBP-1 ) , an ***inhibitor*** of ***IGF-I*** action ] retards postnatal brain growth .	negative	1
1071	10088664	185;183	AT1R;angiotensin II	The type 1 ***angiotensin II*** ***receptor*** ( ***AT1R*** ) predominates in adult vascular smooth muscle ( VSM ) and mediates vasoconstriction .	parallel	1
1072	10088720	960;6696	CD44;osteopontin	These studies suggest that ******CD44-osteopontin****** ***interactions*** may not be common in vivo and may be limited to a specific CD44 isoform ( s ) , and/or a particular modified form of osteopontin .	parallel	1
1073	10088730	7040;860	TGF-beta1;CBFA1	***TGF-beta1*** treatment effectively suppressed myogenesis and ***induced*** ***CBFA1*** expression but was insufficient to support osteoblast differentiation reflected by the absence of ALP , OPN , and OCN .	target	1
1074	10088775	142;836	PARP;caspase 3	In addition , FAS ligation to TNFalpha-treated cultured OA synoviocytes induced activation of caspase 8 and caspase 3 , with subsequent cleavage of poly ( ADP-ribose ) polymerase ( ***PARP*** ) , a ***substrate*** of activated ***caspase 3*** .	parallel	1
1075	10088775	355;836	FAS;caspase 3	In addition , ***FAS*** ligation to TNFalpha-treated cultured OA synoviocytes ***induced*** activation of caspase 8 and ***caspase 3*** , with subsequent cleavage of poly ( ADP-ribose ) polymerase ( PARP ) , a substrate of activated caspase 3 .	target	1
1076	10088775	355;841	FAS;caspase 8	In addition , ***FAS*** ligation to TNFalpha-treated cultured OA synoviocytes ***induced*** activation of ***caspase 8*** and caspase 3 , with subsequent cleavage of poly ( ADP-ribose ) polymerase ( PARP ) , a substrate of activated caspase 3 .	target	1
1077	10089132	3553;4790	IL-1beta;NF-kappaB	PD 098059 , a selective inhibitor of the ERK activating kinase MEK1 , had no effect on IL-1beta-induced MCP-1 mRNA or protein levels , or on ***IL-1beta*** ***activation*** of ***NF-kappaB*** .	positive	1
1078	10089132	3553;6347	IL-1beta;MCP-1	These data indicate that p38 kinase is necessary for the ***induction*** of ***MCP-1*** expression by ***IL-1beta*** , but is not involved at the level of cytoplasmic activation of NF-kappaB .	target	1
1079	10089132	3553;4790	IL-1beta;NF-kappaB	Because NF-kappaB is necessary for MCP-1 gene expression , the effect of p38 kinase inhibition on ***IL-1beta*** ***induction*** of ***NF-kappaB*** was measured .	target	1
1080	10089132	3553;5594	IL-1beta;ERK2	Our previous work showed that ***IL-1beta*** also ***activates*** the MAP kinase ***ERK2*** in human mesangial cells .	positive	1
1081	10089138	3553;1906	IL-1beta;endothelin 1	***Upregulation*** of ***endothelin 1*** and its precursor by ***IL-1beta*** , TNF-alpha , and TGF-beta in the PC3 human prostate cancer cell line .	positive	1
1082	10089138	7040;1906	TGF-beta;endothelin 1	***Upregulation*** of ***endothelin 1*** and its precursor by IL-1beta , TNF-alpha , and ***TGF-beta*** in the PC3 human prostate cancer cell line .	positive	1
1083	10089138	7124;1906	TNF-alpha;endothelin 1	***Upregulation*** of ***endothelin 1*** and its precursor by IL-1beta , ***TNF-alpha*** , and TGF-beta in the PC3 human prostate cancer cell line .	positive	1
1084	10089877	578;598	BAK;BCL-XL	Furthermore , we modeled a complex of BCL-XL and BID by aligning the BID and BAK BH3 motifs in the known ******BCL-XL-BAK****** BH3 ***complex*** .	parallel	1
1085	10089877	637;598	BID;BCL-XL	Furthermore , we modeled a ***complex*** of ***BCL-XL*** and ***BID*** by aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex .	parallel	1
1086	10089882	920;3700	CD4;gp120	Sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha , MIP-1 beta , and HIV-1 ******gp120/CD4****** ***complexes*** and to the ability of HIV-1 to enter cells expressing CCR5 and CD4 .	parallel	1
1087	10089902	3586;1437	IL-10;CSF	It was shown earlier than ***IL-10*** ***regulates*** ***CSF*** secretion by monocytes in an autocrine manner .	target	1
1088	10089905	3458;355	interferon-gamma;CD95	Fas antigen ( ***CD95*** ) in pure erythroid cell line AS-E2 is ***induced*** by ***interferon-gamma*** and tumor necrosis factor-alpha and potentiates apoptotic death .	target	1
1089	10089905	7124;355	tumor necrosis factor-alpha;CD95	Fas antigen ( ***CD95*** ) in pure erythroid cell line AS-E2 is ***induced*** by interferon-gamma and ***tumor necrosis factor-alpha*** and potentiates apoptotic death .	target	1
1090	10090153	4091;4087	Smad6;Smad2	Finally , the Smadl-specific antagonist ***Smad6*** can ***inhibit*** a ***Smad2*** molecule harboring Smadl C1 and C2 sequences .	negative	1
1091	10090156	1906;3383	endothelin-1;intercellular adhesion molecule-1	***Downregulation*** of ***intercellular adhesion molecule-1*** expression on human synovial fibroblasts by ***endothelin-1*** .	negative	1
1092	10090156	7124;3383	TNF-alpha;ICAM-1	RESULTS : Tumor necrosis factor-alpha ( ***TNF-alpha*** ) ***increased*** the expression of ***ICAM-1*** by RA and OA fibroblasts .	positive	0
1093	10090177	3553;7132	IL-1beta;TNF-R55	CONCLUSION : The expression of ***TNF-R55*** and TNF-R75 on human articular chondrocytes is ***modulated*** independently by ***IL-1beta*** , TNF-alpha , and bFGF , suggesting a role of these regulatory mechanisms in the degradation processes of human articular cartilage in inflammatory joint diseases .	target	0
1094	10090177	3553;7133	IL-1beta;TNF-R75	CONCLUSION : The expression of TNF-R55 and ***TNF-R75*** on human articular chondrocytes is ***modulated*** independently by ***IL-1beta*** , TNF-alpha , and bFGF , suggesting a role of these regulatory mechanisms in the degradation processes of human articular cartilage in inflammatory joint diseases .	target	0
1095	10090177	7124;7132	TNF-alpha;TNF-R55	CONCLUSION : The expression of ***TNF-R55*** and TNF-R75 on human articular chondrocytes is ***modulated*** independently by IL-1beta , ***TNF-alpha*** , and bFGF , suggesting a role of these regulatory mechanisms in the degradation processes of human articular cartilage in inflammatory joint diseases .	target	0
1096	10090177	7124;7133	TNF-alpha;TNF-R75	CONCLUSION : The expression of TNF-R55 and ***TNF-R75*** on human articular chondrocytes is ***modulated*** independently by IL-1beta , ***TNF-alpha*** , and bFGF , suggesting a role of these regulatory mechanisms in the degradation processes of human articular cartilage in inflammatory joint diseases .	target	0
1097	10090417	183;7432	angiotensin II;vasoactive intestinal peptide	***angiotensin II*** did not stimulate cyclic AMP or ***suppress*** ***vasoactive intestinal peptide*** stimulated cyclic AMP production over the concentration range that caused Ca2 + signaling .	negative	1
1098	10090720	5649;1600	Reln;Dab1	In primary neuronal cultures , ***Dab1*** tyrosine phosphorylation is ***stimulated*** by exogenous ***Reln*** .	positive	0
1099	10090723	7029;1874	DP2;E2F4	The crystal structure of an ******E2F4-DP2-DNA****** ***complex*** shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif .	parallel	1
1100	10090724	1111;995	Chk1;Cdc25C	An additional role for 14-3-3 proteins in the DNA-damage checkpoint has been suggested based on the observation that human ***Chk1*** can ***phosphorylate*** ***Cdc25C*** in vitro creating a 14-3-3 binding site .	target	1
1101	10090765	5337;857	PLD1;caveolin-1	Purified ***PLD1*** directly ***bound*** to a glutathione ***S-transferase-caveolin-1*** fusion protein in in vitro binding assays .	parallel	1
1102	10090765	857;5337	caveolin-1;PLD1	The association of PLD1 with caveolin-1 could be completely eliminated by preincubation of PLD1 with an oligopeptide corresponding to the scaffolding domain ( amino acids 82-101 ) of caveolin-1 , indicating that ***caveolin-1*** ***interacts*** with ***PLD1*** through the scaffolding domain .	parallel	1
1103	10090765	5337;857	PLD1;caveolin-1	The ***association*** of ***PLD1*** with ***caveolin-1*** could be completely eliminated by preincubation of PLD1 with an oligopeptide corresponding to the scaffolding domain ( amino acids 82-101 ) of caveolin-1 , indicating that caveolin-1 interacts with PLD1 through the scaffolding domain .	parallel	0
1104	10090765	857;5337	caveolin-1;PLD1	***caveolin-1*** also ***coimmunoprecipitated*** with ***PLD1*** in the absence of PMA , and the amounts of coimmunoprecipitated caveolin-1 decreased in response to treatment with PMA .	parallel	1
1105	10090765	5337;857	PLD1;caveolin-1	Taken together , our results suggest a new mechanism for the regulation of the PKCalpha-dependent PLD activity through the molecular ***interaction*** between ***PLD1*** , PKCalpha , and ***caveolin-1*** in caveolae .	parallel	1
1106	10090848	7057;5340	thrombospondin 1;plasmin	We previously showed that ***thrombospondin 1*** ( TSP-1 ) ***upregulates*** the ***plasminogen/plasmin*** system and promotes breast tumor cell invasion .	positive	1
1107	10090924	7124;7852	tumor necrosis factor-alpha;chemokine receptor	Metalloproteinases are involved in lipopolysaccharide - and ***tumor necrosis factor-alpha-mediated*** ***regulation*** of CXCR1 and CXCR2 ***chemokine receptor*** expression .	target	1
1108	10090924	7124;3577	tumor necrosis factor-alpha;CXCR1	Metalloproteinases are involved in lipopolysaccharide - and ***tumor necrosis factor-alpha-mediated*** ***regulation*** of ***CXCR1*** and CXCR2 chemokine receptor expression .	target	1
1109	10090924	7124;3579	tumor necrosis factor-alpha;CXCR2	Metalloproteinases are involved in lipopolysaccharide - and ***tumor necrosis factor-alpha-mediated*** ***regulation*** of CXCR1 and ***CXCR2*** chemokine receptor expression .	target	1
1110	10090941	3558;596	IL-2;Bcl-2	In contrast , ***IL-2-dependent*** ***induction*** of ***Bcl-2*** was unaffected .	target	1
1111	10090941	3561;3718	gammac;JAK3	In naive T cells , but not primed T cells , PGE2 and other cAMP elevating agents also caused a modest reduction in surface expression of the common gamma chain ( ***gammac*** ) that ***associates*** with ***JAK3*** .	parallel	0
1112	10090945	355;356	CD95;CD95L	We have previously shown that nitric oxide ( NO ) stimulates apoptosis in different human neoplastic lymphoid cell lines through activation of caspases not only via ******CD95/CD95L****** ***interaction*** , but also independently of such death receptors .	parallel	1
1113	10090947	5970;4790	p65;p50	Whereas the NF-kappaB binding activity in Tax-expressing T-cell lines consisted mostly of p50/c-Rel , fresh ATL samples contained p50/p50 and ******p50/p65****** ***heterodimers*** .	parallel	1
1114	10090948	25;3717	BCR/ABL;JAK2	The constitutive activation of ***JAK2/STAT5*** in Dami/HEL cells is ***triggered*** by a mechanism other than autocrine cytokines or the ***BCR/ABL*** oncoprotein .	positive	0
1115	10090948	25;6776	BCR/ABL;STAT5	The constitutive activation of ***JAK2/STAT5*** in Dami/HEL cells is ***triggered*** by a mechanism other than autocrine cytokines or the ***BCR/ABL*** oncoprotein .	positive	0
1116	1009100	847;392636	catalase;alkylglycerol monooxygenase	***Stimulation*** of the microsomal ***alkylglycerol monooxygenase*** by ***catalase*** .	positive	0
1117	10091598	3929;929	LBP;CD14	An ***LPS/LBP*** complex was an effective ***stimulator*** for LBP and ***CD14*** production in HepG2 cells , but stimulation of the cells with either LPS or LBP alone did not significantly accelerate the production of these proteins .	positive	0
1118	10091607	3596;5743	IL-13;COX-2	***IL-13*** ***inhibited*** IL-1 beta/TNF-alpha-elicited PGE2 production , as well as ***COX-2*** protein and mRNA expression in a concentration-dependent fashion .	negative	1
1119	10092062	958;959	CD40;CD40 ligand	We determined the role of ***interactions*** between ***CD40*** and ***CD40 ligand*** ( CD40L ) in these infiltrating lymphocytes on B-cell differentiation and expression of Bcl-2 family proteins .	parallel	1
1120	10092076	4790;356	NF-kappaB;Fas ligand	Apoptosis-resistant T cells have a deficiency in ***NF-kappaB-mediated*** ***induction*** of ***Fas ligand*** transcription .	target	1
1121	10092077	3821;3824	NKG2;CD94	They include killer inhibitory receptors and ******CD94/NKG2****** ***heterodimers*** in humans and the Ly49 family in mice .	parallel	1
1122	10092081	940;896	CD28;cyclin D3	***CD28*** costimulation ***enhanced*** expression of ***cyclin D3*** and induced down-regulation of p27kip1 expression .	positive	0
1123	10092084	4179;718	CD46;C3b	These data indicate that ***CD46*** ***prevents*** the ***C3b*** deposition amplification loop mediated by the alternative C3 convertase and , consequently , inhibits the formation of the alternative C5 convertase .	negative	0
1124	10092084	4179;718	CD46;C3b	***Control*** of ***C3b*** and C5b deposition by ***CD46*** ( membrane cofactor protein ) after alternative but not classical complement activation .	target	0
1125	10092084	4179;727	CD46;C5b	***Control*** of C3b and ***C5b*** deposition by ***CD46*** ( membrane cofactor protein ) after alternative but not classical complement activation .	target	0
1126	10092086	1493;3725	CTLA4;AP-1	***CTLA4*** ligation ***attenuates*** ***AP-1*** , NFAT and NF-kappaB activity in activated T cells .	negative	0
1127	10092086	1493;4790	CTLA4;NF-kappaB	***CTLA4*** ligation ***attenuates*** AP-1 , NFAT and ***NF-kappaB*** activity in activated T cells .	negative	0
1128	10092086	1493;3725	CTLA4;AP-1	We found that cross-linking ***CTLA4*** on activated T cells completely ***blocks*** ***AP-1*** and NFAT transcription factor activity before any effects on T cell proliferation can be observed , with NF-kappaB activity affected to a lesser degree .	negative	0
1129	10092086	3725;1493	AP-1;CTLA4	The suppression of ***AP-1*** and NFAT transcriptional activity ***correlates*** with reduced levels of AP-1 and NFAT DNA binding as early as 10 h after T cell activation , prior to detectable up-regulation of ***CTLA4*** on the T cell surface .	parallel	0
1130	10092088	1493;4792	CTLA-4;IkappaBalpha	Cytotoxic T lymphocyte antigen 4 ( ***CTLA-4*** ) ***inhibits*** CD28-induced ***IkappaBalpha*** degradation and RelA activation .	negative	1
1131	10092088	1493;5970	CTLA-4;RelA	Cytotoxic T lymphocyte antigen 4 ( ***CTLA-4*** ) ***inhibits*** CD28-induced IkappaBalpha degradation and ***RelA*** activation .	negative	1
1132	10092088	1493;3558	CTLA-4;IL-2	The results show that ***CTLA-4*** stimulation ***inhibits*** ***IL-2*** production induced by CD3-CD28 co-stimulation .	negative	1
1133	10092091	4790;355	NF-kappaB;Fas	***NF-kappaB*** ***regulates*** ***Fas/APO-1/CD95*** - and TCR - mediated apoptosis of T lymphocytes .	target	1
1134	10092212	1191;4609	clusterin;c-myc	We examined the ***response*** of the rat ***clusterin*** gene to two oncogenes , Ha-ras and ***c-myc*** , in transfected Rat1 fibroblasts .	parallel	0
1135	10092305	7039;8513	transforming growth factor alpha;gastric lipase	Epidermal growth factor and ***transforming growth factor alpha*** ***down-regulate*** human ***gastric lipase*** gene expression .	negative	1
1136	10092305	7039;8513	TGF-alpha;HGL	EGF and/or ***TGF-alpha*** ***down-regulated*** ***HGL*** mRNA levels and decreased enzymic activity .	negative	1
1137	10092317	885;5867	CCK;Rab4	CONCLUSIONS : ***Rab4*** negatively modulates regulated exocytosis of pancreatic acini and is ***controlled*** by ***CCK*** through a protein kinase C pathway .	target	0
1138	10092317	885;5867	cholecystokinin;Rab4	The ***regulation*** of ***Rab4*** by ***cholecystokinin*** ( CCK ) and 12-O-tetradecanoyl-phorbol 13-acetate ( TPA ) was investigated by examining their effects on [ 32P ] GTP binding rate into the Rab4 immunoprecipitates .	target	1
1139	10092317	885;5867	CCK;Rab4	The participation of protein kinase C in the ***Rab4*** ***regulation*** by ***CCK*** was confirmed by calphostin C pretreatment of acini .	target	1
1140	10092515	1950;5335	EGF;PLC-gamma1	In cultured hepatocytes from control rats , ***EGF*** rapidly ***induced*** tyrosine phosphorylation of both the EGFR and of ***PLC-gamma1*** .	target	1
1141	10092515	1950;5335	EGF;PLC-gamma1	***EGF*** also ***stimulated*** ***PLC-gamma1*** translocation from cytosol to a cytoskeletal compartment where PLC-gamma1 interacted with EGFR .	positive	0
1142	10092517	4738;8453	NEDD8;cullin-2	Here , we show that human ***cullin-2*** is also ***conjugated*** by a single molecule of the ***NEDD8*** .	parallel	1
1143	10092522	1500;3055	p120;Hck	The proto-oncogene ***p120*** ( Cbl ) is a downstream ***substrate*** of the ***Hck*** protein-tyrosine kinase .	parallel	1
1144	10092522	867;3055	Cbl;Hck	Hck phosphorylates Cbl in vitro and the ***interaction*** between ***Cbl*** and ***Hck*** is direct , requiring Hck 's unique , SH3 and SH2 domains for optimal binding .	parallel	1
1145	10092522	3055;867	Hck;Cbl	***Hck*** ***phosphorylates*** ***Cbl*** in vitro and the interaction between Cbl and Hck is direct , requiring Hck 's unique , SH3 and SH2 domains for optimal binding .	target	1
1146	10092522	867;3055	Cbl;Hck	Using a novel estrogen-regulated chimera of Hck we have shown a hormone-dependent ***association*** between ***Hck*** and ***Cbl*** in murine fibroblasts .	parallel	0
1147	10092539	183;5747	angiotensin II;FAK	In adherent cells , both ***FAK*** and paxillin were tyrosine ***phosphorylated*** by ***angiotensin II*** , while the cell detachment completely inhibited the tyrosine phosphorylation of paxillin .	target	1
1148	10092539	183;5829	angiotensin II;paxillin	In adherent cells , both FAK and ***paxillin*** were tyrosine ***phosphorylated*** by ***angiotensin II*** , while the cell detachment completely inhibited the tyrosine phosphorylation of paxillin .	target	1
1149	10092539	8506;5829	p190;paxillin	Moreover , ***p190*** , a member of Rho GTPase activating protein ( GAP ) , and RasGAP were coprecipitated with paxillin in adherent cells and angiotensin II stimulation ***reduced*** the formation of paxillin-p190 and ***paxillin-RasGAP*** complexes .	negative	1
1150	10092539	8506;5921	p190;RasGAP	Moreover , ***p190*** , a member of Rho GTPase activating protein ( GAP ) , and RasGAP were coprecipitated with paxillin in adherent cells and angiotensin II stimulation ***reduced*** the formation of paxillin-p190 and ***paxillin-RasGAP*** complexes .	negative	1
1151	10092539	5829;8506	paxillin;p190	Moreover , p190 , a member of Rho GTPase activating protein ( GAP ) , and RasGAP were coprecipitated with paxillin in adherent cells and angiotensin II stimulation reduced the formation of ******paxillin-p190****** and paxillin-RasGAP ***complexes*** .	parallel	1
1152	10092539	5829;5921	paxillin;RasGAP	Moreover , p190 , a member of Rho GTPase activating protein ( GAP ) , and RasGAP were coprecipitated with paxillin in adherent cells and angiotensin II stimulation reduced the formation of paxillin-p190 and ******paxillin-RasGAP****** ***complexes*** .	parallel	1
1153	10092546	10859;3107	LIR-1;HLA-C	We show that ***HLA-C*** recognition by decidual NK cells can be ***mediated*** by p58 , ***LIR-1*** and ( indirectly ) by CD94/NKG2A receptors .	target	0
1154	10092546	3804;3107	p58;HLA-C	We show that ***HLA-C*** recognition by decidual NK cells can be ***mediated*** by ***p58*** , LIR-1 and ( indirectly ) by CD94/NKG2A receptors .	target	0
1155	10092546	3824;3135	CD94;HLA-G	On the other hand , ***HLA-G*** recognition is not only ***mediated*** by LIR-1 and ( indirectly ) by ***CD94/NKG2A*** but also by a newly identified receptor termed p49 .	target	0
1156	10092546	10859;3135	LIR-1;HLA-G	On the other hand , ***HLA-G*** recognition is not only ***mediated*** by ***LIR-1*** and ( indirectly ) by CD94/NKG2A but also by a newly identified receptor termed p49 .	target	0
1157	10092546	3821;3135	NKG2A;HLA-G	On the other hand , ***HLA-G*** recognition is not only ***mediated*** by LIR-1 and ( indirectly ) by ***CD94/NKG2A*** but also by a newly identified receptor termed p49 .	target	0
1158	10092547	3824;3133	CD94;HLA-E	By contrast , our data support that NK recognition of cells expressing HLA-G1 involves at least two non-overlapping receptor-ligand systems : ( 1 ) the direct engagement of the ILT2 ( LIR1 ) receptor by HLA-G1 ; and ( 2 ) the ***interaction*** of CD94/NKG2A and ***CD94/NKG2C*** receptors with the non-classical class I molecule ***HLA-E*** , co-expressed on the surface upon binding to a nonamer ( VMAPRTLFL ) from the HLA-G leader sequence .	parallel	1
1159	10092547	3821;3133	NKG2A;HLA-E	By contrast , our data support that NK recognition of cells expressing HLA-G1 involves at least two non-overlapping receptor-ligand systems : ( 1 ) the direct engagement of the ILT2 ( LIR1 ) receptor by HLA-G1 ; and ( 2 ) the ***interaction*** of ***CD94/NKG2A*** and CD94/NKG2C receptors with the non-classical class I molecule ***HLA-E*** , co-expressed on the surface upon binding to a nonamer ( VMAPRTLFL ) from the HLA-G leader sequence .	parallel	1
1160	10092585	5663;8502	presenilin 1;p0071	Direct ***interaction*** of Alzheimer 's disease-related ***presenilin 1*** with armadillo protein ***p0071*** .	parallel	1
1161	10092585	1499;5663	armadillo;presenilin 1	We utilized the yeast two-hybrid system to identify an interacting ***armadillo*** protein , termed p0071 , that ***binds*** specifically to the hydrophilic loop of ***presenilin 1*** .	parallel	1
1162	10092585	5663;8502	presenilin 1;p0071	Here , we show that the C-terminal fragment of ***presenilin 1*** directly ***binds*** to ***p0071*** .	parallel	1
1163	10092586	715;716	C1r;C1s	Ca2 + - dependent ***interaction*** of intact ***C1r*** with ***C1s*** was studied using surface plasmon resonance spectroscopy , yielding KD values of 10.9-29 .7 nM .	parallel	1
1164	10092624	7040;5054	TGFbeta;PAI-1	Transforming growth factor beta ( ***TGFbeta*** ) ***activates*** transcription of the plasminogen activator inhibitor type-1 ( ***PAI-1*** ) gene through a major TGFbeta-responsive region ( -740 and -647 ) in the PAI-1 promoter .	positive	1
1165	10092624	4089;5054	Smad4;PAI-1	Both elements were required for TGFbeta-induced , Smad3 - and ***Smad4-dependent*** ***activation*** of ***PAI-1*** transcription .	positive	1
1166	10092648	1234;3700	CCR5;gp120	By contrast , N-terminal mAbs blocked ******gp120-CCR5****** ***binding*** more effectively than ECL2 mAbs .	parallel	1
1167	10092656	3458;3394	interferon gamma;ICSBP	Furthermore , transcriptional ***activation*** of ***ICSBP*** gene by ***interferon gamma*** is accompanied by selective nuclear localization of ICSBP in proliferating epithelial cells but not in the nuclei of nondividing cells in the lens fiber compartment .	positive	1
1168	10092660	719;718	C3aR;C3a	The ***C3a*** anaphylatoxin ***receptor*** ( ***C3aR*** ) is a G protein-coupled receptor with an unusually large second extracellular loop ( e2 loop , approximately 172 amino acids ) .	parallel	1
1169	10092660	728;727	C5aR;C5a	Whereas replacement of the C3aR N-terminal segment with that from the human C5a receptor had minimal effect on C3a binding , substitution of the e2 loop with a smaller e2 loop from the ***C5a*** ***receptor*** ( ***C5aR*** ) abolished binding of 125I-C3a and C3a-stimulated calcium mobilization .	parallel	1
1170	10092676	7041;5782	Hic-5;PTP-PEST	***Hic-5*** , a paxillin homologue , ***binds*** to the protein-tyrosine phosphatase PEST ( ***PTP-PEST*** ) through its LIM 3 domain .	parallel	1
1171	10092678	6464;10818	Shc;FRS-2	Importantly , we demonstrate that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc , suggesting a model in which competitive ***binding*** between ***FRS-2*** and ***Shc*** regulates differentiation versus proliferation .	parallel	1
1172	10092678	10818;1398	FRS-2;Crk	Consistent with this model , ***FRS-2*** ***binds*** Grb-2 , ***Crk*** , the SH2 domain containing tyrosine phosphatase SH-PTP-2 , the cyclin-dependent kinase substrate p13 ( suc1 ) , and the Src homology 3 ( SH3 ) domain of Src , providing a functional link between TrkA , cell cycle , and multiple NGF signaling effectors .	parallel	1
1173	10092678	10818;2885	FRS-2;Grb-2	Consistent with this model , ***FRS-2*** ***binds*** ***Grb-2*** , Crk , the SH2 domain containing tyrosine phosphatase SH-PTP-2 , the cyclin-dependent kinase substrate p13 ( suc1 ) , and the Src homology 3 ( SH3 ) domain of Src , providing a functional link between TrkA , cell cycle , and multiple NGF signaling effectors .	parallel	1
1174	10092696	941;920	CD80;CD4	Expression of ***CD80*** in macrophages ***correlated*** with the BAL ***CD4/CD8*** ratio .	parallel	0
1175	10092696	941;925	CD80;CD8	Expression of ***CD80*** in macrophages ***correlated*** with the BAL ***CD4/CD8*** ratio .	parallel	0
1176	10092768	5599;3725	JNK;AP-1	In contrast , the dominant-active ***JNK*** kinase kinase , MEKK1 , ***induced*** ***CD28RE/AP-1*** luciferase activity , in parallel with induction of c-Jun and c-Rel binding to this combined promoter site .	target	1
1177	10092768	4214;3725	MEKK1;AP-1	In contrast , the dominant-active JNK kinase kinase , ***MEKK1*** , ***induced*** ***CD28RE/AP-1*** luciferase activity , in parallel with induction of c-Jun and c-Rel binding to this combined promoter site .	target	1
1178	10092768	4214;3551	MEKK1;IKK beta	Dominant-active ***MEKK1*** also ***induced*** transfected ***IKK beta*** , but not IKK alpha , activity .	target	1
1179	10092779	356;355	FasL;Fas	Contrary to the prevailing view that tumor cells cause the death of anti-tumor T cells by expressing ***Fas*** ***ligand*** ( ***FasL*** ) , our data suggested that FasL was instead expressed by T lymphocytes upon activation .	parallel	1
1180	10092813	3553;3458	IL-1 beta;IFN-gamma	We found that IFN-gamma , but not TNF-alpha or IL-1 beta , strongly induced IP-10 , Mig , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and ***IL-1 beta*** ***synergized*** with ***IFN-gamma*** induction in all three cell types .	parallel	0
1181	10092813	7124;3458	TNF-alpha;IFN-gamma	We found that IFN-gamma , but not TNF-alpha or IL-1 beta , strongly induced IP-10 , Mig , and I-TAC mRNA accumulation mainly in NHBEC and that ***TNF-alpha*** and IL-1 beta ***synergized*** with ***IFN-gamma*** induction in all three cell types .	parallel	0
1182	10092813	3458;3627	IFN-gamma;IP-10	We found that ***IFN-gamma*** , but not TNF-alpha or IL-1 beta , strongly ***induced*** ***IP-10*** , Mig , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types .	target	1
1183	10092813	3458;6373	IFN-gamma;I-TAC	We found that ***IFN-gamma*** , but not TNF-alpha or IL-1 beta , strongly ***induced*** IP-10 , Mig , and ***I-TAC*** mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types .	target	1
1184	10092818	3586;5724	IL-10;platelet-activating factor receptor	Hence , we observed that ***IL-10*** ***augmented*** two-to threefold ***platelet-activating factor receptor*** ( PAF-R ) expression , whereas it had no significant effect on the fifth component of complement ( C5a ) receptor ( C5a-R ) expression .	positive	0
1185	10092882	3339;2199	perlecan;fibulin-2	Recombinant domain IV of ***perlecan*** ***binds*** to nidogens , laminin-nidogen complex , fibronectin , ***fibulin-2*** and heparin .	parallel	1
1186	10092883	1509;1514	cathepsin D;cathepsin L	Aspartic protease ***cathepsin D*** was shown to ***cleave*** denatured , but not active ***cathepsin L*** , suggesting a potential mechanism for in-vivo regulation and turnover of cathepsin L inside lysosomes .	target	1
1187	10092989	3458;3383	Interferon-gamma;ICAM-1	***Interferon-gamma*** ***up-regulated*** HLA-DR and ***ICAM-1*** expression on both cells , whereas lipopolysaccharide increased ICAM-1 expression only on SW 1116 .	positive	1
1188	10093540	3929;929	lipopolysaccharide-binding protein;CD14 molecule	The activation of monocytes and macrophages induced by lipopolysaccharide has been shown to contribute to the ***binding*** of lipopolysaccharide and ***lipopolysaccharide-binding protein*** complex to the cell surface ***CD14 molecule*** .	parallel	1
1189	10093970	2185;6714	PYK2;Src	Suppression of protein kinase C is associated with inhibition of PYK2 tyrosine phosphorylation and enhancement of ***PYK2*** ***interaction*** with ***Src*** in thrombin-activated platelets .	parallel	1
1190	10093970	2185;6714	PYK2;Src	While PYK2 tyrosine phosphorylation induced by thrombin was inhibited by preincubation of platelets with PKC inhibitors , staurosporine and Ro31-8220 , ***PYK2*** ***association*** with ***Src*** was markedly enhanced under the same conditions .	parallel	0
1191	10093970	2185;6714	PYK2;Src	These results suggest that PKC activation ( but not Ca2 + mobilization ) is involved in PYK2 tyrosine phosphorylation and that ***PYK2*** ***associates*** with ***Src*** without PYK2 tyrosine phosphorylation or p130Cas involvement in platelets .	parallel	0
1192	10094049	6885;7189	TAK1;TRAF6	Here we show that the MAPKK kinase TAK1 acts upstream of NIK in the IL-1-activated signalling pathway and that ***TAK1*** ***associates*** with ***TRAF6*** during IL-1 signalling .	parallel	0
1193	10094049	6885;4790	TAK1;NF-kappaB	Stimulation of TAK1 causes activation of NF-kappaB , which is blocked by dominant-negative mutants of NIK , and an inactive ***TAK1*** mutant ***prevents*** activation of ***NF-kappaB*** that is mediated by IL-1 but not by NIK .	positive	0
1194	10094049	9020;4790	NIK;NF-kappaB	Stimulation of TAK1 causes activation of ***NF-kappaB*** , which is ***blocked*** by dominant-negative mutants of ***NIK*** , and an inactive TAK1 mutant prevents activation of NF-kappaB that is mediated by IL-1 but not by NIK .	positive	0
1195	10094049	6885;9020	TAK1;NIK	Activated ***TAK1*** ***phosphorylates*** ***NIK*** , which stimulates IKK-alpha activity .	target	1
1196	10094049	9020;1147	NIK;IKK-alpha	Activated TAK1 phosphorylates ***NIK*** , which ***stimulates*** ***IKK-alpha*** activity .	positive	0
1197	10094132	7124;1232	TNF-alpha;CCR3	Interestingly , ***TNF-alpha*** was able to ***induce*** CCR1 , ***CCR3*** as well as CXCR1 , CXCR2 , CXCR4 receptors and Burkitt 's lymphoma receptor BLR2 .	target	1
1198	10094132	7124;3577	TNF-alpha;CXCR1	Interestingly , ***TNF-alpha*** was able to ***induce*** CCR1 , CCR3 as well as ***CXCR1*** , CXCR2 , CXCR4 receptors and Burkitt 's lymphoma receptor BLR2 .	target	1
1199	10094144	351;57419	amyloid precursor protein;sodium/calcium exchanger	C-terminal fragment of Alzheimer 's ***amyloid precursor protein*** ***inhibits*** ***sodium/calcium exchanger*** activity in SK-N-SH cell .	negative	1
1200	10094147	351;43	Abeta;acetylcholinesterase	In particular , ***Abeta*** has been shown to ***induce*** the expression of ***acetylcholinesterase*** in the brains of CT-100-expressing transgenic mice and in cell culture experiments .	target	1
1201	10094400	689;1457	BTF3a;protein kinase CK2	We report here on the ***interaction*** between the other isoform , ***BTF3a*** , and ***protein kinase CK2*** .	parallel	1
1202	10094400	1457;689	protein kinase CK2;BTF3a	The data show a weak , nevertheless specific ***interaction*** of ***protein kinase CK2*** via subunit beta with the putative transcription factor ***BTF3a*** in vitro and in vivo , and a role of BTF3a as a potential new substrate for CK2 .	parallel	1
1203	10094408	1457;7157	Protein kinase CK2;p53	***Protein kinase CK2-dependent*** ***regulation*** of ***p53*** function : evidence that the phosphorylation status of the serine 386 ( CK2 ) site of p53 is constitutive and stable .	target	1
1204	10094466	2520;5747	Gastrin;p125FAK	***Gastrin*** ***stimulates*** the formation of a ***p60Src/p125FAK*** complex upstream of the phosphatidylinositol 3-kinase signaling pathway .	positive	0
1205	10094469	7157;6273	p53;S100A2	Transcriptional ***activation*** of the human ***S100A2*** promoter by wild-type ***p53*** .	positive	1
1206	10094469	6273;7157	S100A2;p53	A potential p53 binding site was identified in the promoter of the ***S100A2*** gene , which ***binds*** to purified p53 as well as ***p53*** in nuclear extract activated by etoposide .	parallel	1
1207	10094469	7157;6273	p53;S100A2	Transactivation assays using the promoter driven luciferase reporters revealed that the ***S100A2*** promoter was transcriptionally ***activated*** by wild-type ***p53*** , but not by p53 mutants , in a dose-dependent as well as a p53 binding site-dependent manner .	positive	1
1208	10094469	7157;6273	p53;S100A2	The ***p53-induced*** ***transactivation*** of the ***S100A2*** promoter was enhanced by etoposide and blocked by a dominant negative p53 mutant .	positive	1
1209	10094469	7157;6273	p53;S100A2	Thus , ***p53*** appears to positively ***regulate*** ***S100A2*** expression .	positive	1
1210	10094478	5080;1045	Pax6;Cdx2/3	***Pax6*** and ***Cdx2/3*** form a functional ***complex*** on the rat glucagon gene promoter G1-element .	parallel	1
1211	10094478	5080;1045	Pax6;Cdx2/3	Two distinct mutations in the G1-element , that both reduce promoter activity by 85-90 % , is shown to eliminate ***binding*** of either ***Pax6*** or ***Cdx2/3*** .	parallel	1
1212	10094478	5080;1045	Pax6;Cdx2/3	Additionally , ***Pax6*** ***enhanced*** ***Cdx2/3*** mediated activation of a glucagon reporter in heterologous cells .	positive	0
1213	10094480	5080;3651	Pax6;Pdx1	***Pax6*** and ***Pdx1*** form a functional ***complex*** on the rat somatostatin gene upstream enhancer .	parallel	1
1214	10094480	3651;5080	Pdx1;Pax6	In heterologous cells , ***Pdx1*** ***potentiated*** ***Pax6*** mediated activation of a somatostatin reporter .	positive	0
1215	10094483	4803;1958	NGF;NGFI-A	Thus , activation of Ras alone is sufficient for the ***induction*** of ***NGFI-A*** by ***NGF*** , whereas an additional pathway ( s ) , besides Ras , is required for the stimulation of NGFI-B and c-fos gene expression .	target	1
1216	10094578	4018;3952	lipoprotein;leptin	***lipoprotein*** ***binding*** of endogenous and exogenously radiolabelled ***leptin*** was studied by preparative ultracentrifugation .	parallel	1
1217	10094816	902;1017	p34;Cdk2	Olomoucine , a potent ***p34*** ( cdc2 ) and ***Cdk2*** ***inhibitor*** , effectively blocked RA-mediated p34 ( cdc2 ) kinase activation and prevented RA-induced apoptosis .	negative	1
1218	10094942	5320;4586	sPLA2;mucin	The increased ***sPLA2*** levels were ***associated*** with a concomitant increase in lysophosphatidylcholine , prostaglandin E2 ( PGE2 ) , and total ***mucin*** concentrations .	parallel	0
1219	10094943	3569;5706	interleukin-6;p44	Lipopolysaccharide induces cholangiocyte proliferation via an ***interleukin-6-mediated*** ***activation*** of ***p44/p42*** mitogen-activated protein kinase .	positive	1
1220	10095033	5594;3308	p38;HSP70	These results suggest that ***p38*** MAPK positively ***regulates*** hypoxia-induced ***HSP70*** expression in astrocytes .	positive	1
1221	10095040	966;4129	min-1;MAOB	Subgroups of animals of each genotype received a continuous intravenous infusion over 30 min of phenylethylamine ( PEA ) , an endogenous ***substrate*** of ***MAOB*** , ( 8 nmol g-1 ***min-1*** in normal saline at a volume rate of 0.11 microl g-1 min-1 ) or saline at the same volume rate .	parallel	1
1222	10095078	627;6616	BDNF;SNAP25	***BDNF*** , but not GDNF , significantly ***enhanced*** the expression of the calcium binding protein calbindin and synaptic protein ***SNAP25*** .	positive	0
1223	10095085	6416;5599	MKK4;JNK	It is well established that ***SAPK/JNK*** activation is ***controlled*** by ***SEK1/MKK4*** , an up-stream MAP kinase kinase .	target	0
1224	10095085	6416;5601	MKK4;SAPK	It is well established that ***SAPK/JNK*** activation is ***controlled*** by ***SEK1/MKK4*** , an up-stream MAP kinase kinase .	target	0
1225	10095448	4193;7157	MDM2;p53	Functional ***inactivation*** of ***p53*** wildtype protein by ***MDM2-expression*** seems to be the major cause of p53-accumulation in chondromatous neoplasms and emphasizes the role of these parameters as additional hint for malignancy .	negative	1
1226	10095788	3952;2194	leptin;fatty acid synthase	Transcriptional ***regulation*** of ***fatty acid synthase*** gene by insulin/glucose , polyunsaturated fatty acid and ***leptin*** in hepatocytes and adipocytes in normal and genetically obese rats .	target	1
1227	10095788	3952;2194	leptin;fatty acid synthase	Transcriptional ***regulation*** of the ***fatty acid synthase*** ( FAS ) gene by insulin/glucose , polyunsaturated fatty acids and ***leptin*** was investigated in hepatocytes and adipocytes of Wistar fatty rats and their lean littermates .	target	1
1228	10096248	2022;7040	CD105;TGF-beta1	***CD105*** , the specific type III vascular ***receptor*** for ***TGF-beta1*** and - beta3 , modulates cell proliferation and ECM production in response to TGF-beta in vitro .	parallel	1
1229	10096248	2022;7040	CD105;TGF-beta1	In this study , we have quantified the levels of TGF-beta1 and soluble ******CD105-TGF-beta1****** ***complex*** in 91 pre-radiotherapy plasma samples from early-stage ( T1 or T2 ) breast cancer patients utilising an enhanced chemiluminescence ELISA system .	parallel	1
1230	10096254	7157;596	p53;Bcl-2	Because ***Bcl-2*** has been reported to be transcriptionally ***repressed*** by ***p53*** , using immuno-histochemistry and mRNA analyses , we have examined Bcl-2 expression in a panel of 10 classical and 3 anaplastic nephroblastomas in which the p53 status had been previously analyzed .	negative	1
1231	10096254	581;596	Bax;Bcl-2	Therefore , we examined the expression of the Bcl-X and ***Bax*** genes , which are known to ***synergize*** and antagonize ***Bcl-2*** , respectively .	parallel	0
1232	10096254	598;596	Bcl-X;Bcl-2	Therefore , we examined the expression of the ***Bcl-X*** and Bax genes , which are known to ***synergize*** and antagonize ***Bcl-2*** , respectively .	parallel	0
1233	10096294	7018;6036	transferrin;EDN	To elicit cellular targeting as well as to block RI binding , ***transferrin*** was ***conjugated*** to a mutant human RNase , rhRNase ( Gly89 ) -- > Cys ) and a mutant ***EDN*** ( Thr87 -- > Cys ) .	parallel	1
1234	10096546	5599;5601	JNK;SAPK	Taken together , our results suggest that Rb is a target protein of SAPK/JNK and that the ***association*** of ******SAPK/JNK****** and Rb mediates IR-induced apoptosis in MM cells .	parallel	0
1235	10096561	958;1437	CD40;granulocyte macrophage colony-stimulating factor	***CD40*** ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein ***up-regulated*** their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6 , IL-8 , tumor necrosis factor-a , and ***granulocyte macrophage colony-stimulating factor*** and also induced a rapid activation of the transcription factor nuclear factor kappaB .	positive	1
1236	10096561	958;3569	CD40;IL-6	***CD40*** ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein ***up-regulated*** their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of ***IL-6*** , IL-8 , tumor necrosis factor-a , and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB .	positive	1
1237	10096561	958;3576	CD40;IL-8	***CD40*** ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein ***up-regulated*** their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6 , ***IL-8*** , tumor necrosis factor-a , and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB .	positive	1
1238	10096561	958;3383	CD40;intercellular adhesion molecule-1	***CD40*** ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein ***up-regulated*** their expression of ***intercellular adhesion molecule-1*** and MHC class I and class II molecules and their secretion of IL-6 , IL-8 , tumor necrosis factor-a , and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB .	positive	1
1239	10096561	958;959	CD40;CD40L	These results indicate that ******CD40-CD40L****** ***interactions*** may play an important role in augmenting antitumor immunity and inducing apoptosis in some CD40-positive immunogenic human MMs .	parallel	1
1240	10096602	5727;6469	Ptc;sonic hedgehog	Lingual expression of the signaling molecule ***sonic hedgehog*** ( Shh ) , its ***receptor*** Patched ( ***Ptc*** ) , and the Shh-activated transcription factor Gli1 were assayed by using in situ hybridization .	parallel	1
1241	10096784	1113;3643	pancreastatin;insulin receptor	***Modulation*** of ***insulin receptor*** signalling by ***pancreastatin*** in HTC hepatoma cells .	target	0
1242	10097072	8600;8792	OPGL;RANK	Recombinant ***OPGL*** ***binds*** specifically to ***RANK*** expressed by transfected cell lines and purified osteoclast progenitors .	parallel	1
1243	10097072	8792;8600	RANK;OPGL	Furthermore , polyclonal Ab against the RANK extracellular domain promotes osteoclastogenesis in bone marrow cultures suggesting that ***RANK*** activation ***mediates*** the effects of ***OPGL*** on the osteoclast pathway .	target	0
1244	10097092	1385;1387	CREB;CBP	Here we report that the adenovirus E1A protein inhibits the acetyltransferase activity of CBP on binding to the C/H3 domain , whereas binding of CREB , or a ***CREB/E1A*** fusion protein to the KIX domain , fails to ***inhibit*** ***CBP*** acetyltransferase activity .	negative	1
1245	10097092	8202;1387	p/CIP;CBP	Surprisingly , ***p/CIP*** can either ***inhibit*** or stimulate ***CBP*** acetyltransferase activity depending on the specific substrate evaluated and the functional domains present in the p/CIP protein .	negative	1
1246	10097113	5599;596	JNK;Bcl-2	***JNK*** , but not ERK or p38 MAPK , appear to be involved in the ***phosphorylation*** of ***Bcl-2*** induced by paclitaxel .	target	1
1247	10097128	8945;4792	FWD1;IkappaBalpha	Ubiquitin-dependent degradation of ***IkappaBalpha*** is ***mediated*** by a ubiquitin ligase Skp1/Cul 1/F-box protein ***FWD1*** .	target	0
1248	10097128	8945;4792	FWD1;IkappaBalpha	Here , we show that ***FWD1*** ( a mouse homologue of Slimb/betaTrCP ) , a member of the F-box/WD40-repeat proteins , is ***associated*** specifically with ***IkappaBalpha*** only when IkappaBalpha is phosphorylated .	parallel	0
1249	10097128	8945;4792	FWD1;IkappaBalpha	The introduction of ***FWD1*** into cells significantly ***promotes*** ubiquitination and degradation of ***IkappaBalpha*** in concert with IkappaB kinases , resulting in nuclear translocation of NF-kappaB .	positive	0
1250	10097128	8945;4792	FWD1;IkappaBalpha	In addition , ***FWD1*** strikingly ***evoked*** the ubiquitination of ***IkappaBalpha*** in the in vitro system .	positive	0
1251	10097128	8945;4792	FWD1;IkappaBalpha	These results suggest that the substrate-specific degradation of IkappaBalpha is mediated by a Skp1/Cull 1/F-box protein ( SCF ) FWD1 ubiquitin-ligase complex and that ***FWD1*** serves as an intracellular ***receptor*** for phosphorylated ***IkappaBalpha*** .	parallel	1
1252	10097128	6500;4792	Skp1;IkappaBalpha	These results suggest that the substrate-specific degradation of ***IkappaBalpha*** is ***mediated*** by a ***Skp1/Cull*** 1/F-box protein ( SCF ) FWD1 ubiquitin-ligase complex and that FWD1 serves as an intracellular receptor for phosphorylated IkappaBalpha .	target	0
1253	10097133	2119;3458	ERM;IFN-gamma	Retroviral expression of ***ERM*** did not restore IFN-gamma production in Stat4-deficient T cells , but ***augmented*** ***IFN-gamma*** expression in Stat4-heterozygous T cells .	positive	0
1254	10097147	8930;4292	MED1;MLH1	***MED1*** , a novel human methyl-CpG-binding endonuclease , ***interacts*** with DNA mismatch repair protein ***MLH1*** .	parallel	1
1255	10097147	8930;4292	MED1;MLH1	The ***MED1*** protein forms a ***complex*** with ***MLH1*** , binds to methyl-CpG-containing DNA , has homology to bacterial DNA repair glycosylases/lyases , and displays endonuclease activity .	parallel	1
1256	10097151	9988;1029	DMP1;ARF	***Induction*** of ***ARF*** tumor suppressor gene expression and cell cycle arrest by transcription factor ***DMP1*** .	target	1
1257	10097151	1869;1029	E2F-1;ARF	Unlike genes such as Myc , adenovirus E1A , and ***E2F-1*** , which , when overexpressed , ***activate*** the ***ARF-p53*** pathway and trigger apoptosis , DMP1 , like ARF itself , does not induce programmed cell death .	positive	1
1258	10097151	1869;9988	E2F-1;DMP1	Unlike genes such as Myc , adenovirus E1A , and ***E2F-1*** , which , when overexpressed , ***activate*** the ARF-p53 pathway and trigger apoptosis , ***DMP1*** , like ARF itself , does not induce programmed cell death .	positive	1
1259	10097151	4609;1029	Myc;ARF	Unlike genes such as ***Myc*** , adenovirus E1A , and E2F-1 , which , when overexpressed , ***activate*** the ***ARF-p53*** pathway and trigger apoptosis , DMP1 , like ARF itself , does not induce programmed cell death .	positive	1
1260	10097151	4609;9988	Myc;DMP1	Unlike genes such as ***Myc*** , adenovirus E1A , and E2F-1 , which , when overexpressed , ***activate*** the ARF-p53 pathway and trigger apoptosis , ***DMP1*** , like ARF itself , does not induce programmed cell death .	positive	1
1261	10098488	3589;9021	IL-11;SOCS-3	***IL-11*** ***induction*** of ***SOCS-3*** indicates an intracellular negative feedback control of cytokine-induced POMC expression and ACTH secretion .	target	1
1262	10098488	3589;5443	Interleukin-11;adrenocorticotropin	***Interleukin-11*** ***stimulates*** proopiomelanocortin gene expression and ***adrenocorticotropin*** secretion in corticotroph cells : evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis .	positive	0
1263	10098488	3589;5443	IL-11;POMC	***POMC*** mRNA expression was ***induced*** by ***IL-11*** ( 0.5 x 10 ( -9 ) M ) and LIF ( 0.5 x 10 ( -9 ) M ) 1.5 + / - 0.18-fold ( P < 0.05 ) and 1.7 + / - 0.13-fold ( P < 0.01 ) , respectively .	target	1
1264	10098488	3589;5443	IL-11;POMC	***POMC*** promoter activity , assayed by a -706 / +64 rat POMC promoter-luciferase construct , was ***stimulated*** by 0.5 x 10 ( -9 ) M ***IL-11*** ( 1.9 + / - 0.06-fold ; P < 0.001 ) and 5 mM Bu2cAMP ( 7.1 + / - 0.52-fold , P < 0.001 ) , and combined treatment of IL-11 plus Bu2cAMP caused a synergistic 11.7 + / -0.71 - fold increase ofluciferase activity ( P < 0.001 vs.	positive	0
1265	10098490	7040;1490	TGFbeta;CTGF	We conclude that in large vessel endothelial cells , cAMP increased intact CTGF protein by inhibiting degradation of CTGF , whereas TGFbeta stimulated neither CTGF mRNA nor protein ; in microvessel cells , ***TGFbeta*** ***increased*** ***CTGF*** mRNA , while both TGFbeta and cAMP stimulated CTGF degradation .	positive	0
1266	10098490	7040;1490	TGFbeta;CTGF	We conclude that in large vessel endothelial cells , cAMP increased intact CTGF protein by inhibiting degradation of CTGF , whereas TGFbeta stimulated neither CTGF mRNA nor protein ; in microvessel cells , TGFbeta increased CTGF mRNA , while both ***TGFbeta*** and cAMP ***stimulated*** ***CTGF*** degradation .	positive	0
1267	10098491	3952;2796	leptin;GnRH	In particular , it has been shown that ***leptin*** may indirectly ***stimulate*** ***GnRH*** release from hypothalamic fragments by acting on interneurons impinging on GnRH-secreting neurons .	positive	0
1268	10098492	7026;5468	ARP-1;PPARgamma	The COUP-TFII ( ***ARP-1*** ) protein specifically bound the LPL PPAR recognition element inelectromobility shift assays and ***interacted*** directly with the ligand-binding domain of ***PPARgamma*** in pull-down experiments .	parallel	1
1269	10098497	3952;1675	Leptin;adipsin	***Leptin*** increased mRNA levels of lipoprotein lipase at 3 days , but ***decreased*** mRNA levels of ***adipsin*** and Leptin at 9 days and decreased lipid droplet formation by 50 % .	negative	0
1270	10098497	3952;4023	Leptin;lipoprotein lipase	***Leptin*** ***increased*** mRNA levels of ***lipoprotein lipase*** at 3 days , but decreased mRNA levels of adipsin and Leptin at 9 days and decreased lipid droplet formation by 50 % .	positive	0
1271	10098502	5443;1545	ACTH;CYP1B1	Twice daily injections of ***ACTH*** to rat pups ( pd3-10 ) failed to significantly ***increase*** the expression of ***CYP1B1*** in pd 10 adrenals , although the injections weakly stimulated steroidogenesis .	positive	0
1272	10098510	3952;3725	Leptin;c-Jun	We find that ***Leptin*** ***induces*** ***c-Jun*** expression and attenuates the transcriptional activity of the glucocorticoid receptor ( GR ) in granulosa cells .	target	1
1273	10098521	5744;5741	PTHrP;PTH	As a model for studying the actions of locally produced PTHrP in vascular smooth muscle in vivo , we developed transgenic mice that overexpress the ***PTH/PTHrP*** ***receptor*** ( ***PTHrP-R*** ) in smooth muscle .	parallel	1
1274	10098589	3976;5443	leukemia inhibitory factor;ACTH	We recently reported ***leukemia inhibitory factor*** ( LIF ) ***increased*** ***ACTH*** secretion and pro-opiomelanocortin mRNA level in the murine corticotroph tumor cell line ( AtT-20 ) .	positive	0
1275	10098589	1392;5443	CRH;ACTH	***CRH*** ( 10 nM ) also ***induced*** ***ACTH*** secretion 2.5-fold ( P < 0.01 ) , and co-treatment of LIF and CRH exhibited 2.8-fold increase of ACTH secretion but no statistical difference from CRH treated group .	target	1
1276	10098731	5443;3576	alpha-melanocyte-stimulating hormone;interleukin 8	Tumour necrosis factor alpha , ( TNF-alpha ) , not , however , IL-2 , interferon-gamma ( IFN-gamma ) , or ( ***alpha-melanocyte-stimulating hormone*** ( alpha-MSH ) was able to ***up-regulate*** RANTES and ***interleukin 8*** secretion .	positive	1
1277	10098731	5443;6352	alpha-melanocyte-stimulating hormone;RANTES	Tumour necrosis factor alpha , ( TNF-alpha ) , not , however , IL-2 , interferon-gamma ( IFN-gamma ) , or ( ***alpha-melanocyte-stimulating hormone*** ( alpha-MSH ) was able to ***up-regulate*** ***RANTES*** and interleukin 8 secretion .	positive	1
1278	10098731	3458;3576	interferon-gamma;interleukin 8	Tumour necrosis factor alpha , ( TNF-alpha ) , not , however , IL-2 , ***interferon-gamma*** ( IFN-gamma ) , or ( alpha-melanocyte-stimulating hormone ( alpha-MSH ) was able to ***up-regulate*** RANTES and ***interleukin 8*** secretion .	positive	1
1279	10098731	3458;6352	interferon-gamma;RANTES	Tumour necrosis factor alpha , ( TNF-alpha ) , not , however , IL-2 , ***interferon-gamma*** ( IFN-gamma ) , or ( alpha-melanocyte-stimulating hormone ( alpha-MSH ) was able to ***up-regulate*** ***RANTES*** and interleukin 8 secretion .	positive	1
1280	10098769	356;355	FasL;Fas	Colorectal carcinoma cells have recently been shown to express ***Fas*** ***ligand*** ( ***FasL*** ) .	parallel	1
1281	10098850	3586;3553	IL-10;IL-1beta	***IL-10*** ***inhibited*** lipopolysaccharide-induced ***IL-1beta*** and tumor necrosis factor-alpha production , lysosomal enzyme activity , and superoxide anion production in a dose-dependent manner , but did not affect granulocyte/ macrophage colony-stimulating factor-dependent proliferation of microglia .	negative	1
1282	10098850	3586;7124	IL-10;tumor necrosis factor-alpha	***IL-10*** ***inhibited*** lipopolysaccharide-induced IL-1beta and ***tumor necrosis factor-alpha*** production , lysosomal enzyme activity , and superoxide anion production in a dose-dependent manner , but did not affect granulocyte/ macrophage colony-stimulating factor-dependent proliferation of microglia .	negative	1
1283	10098850	3586;3558	IL-10;IL-2	***IL-10*** also ***decreased*** mRNA expression of ***IL-2*** and IL-6 cytokine receptors .	negative	0
1284	10098850	3586;3569	IL-10;IL-6	***IL-10*** also ***decreased*** mRNA expression of IL-2 and ***IL-6*** cytokine receptors .	negative	0
1285	10098873	2885;1605	Grb2;beta-dystroglycan	***Grb2*** , an adaptor protein involved in signal transduction and cytoskeleton organization , has been shown to ***bind*** ***beta-dystroglycan*** .	parallel	1
1286	10098873	5747;1605	FAK;beta-dystroglycan	At the synapses , the adaptor protein Grb2 may mediate ******FAK-beta-dystroglycan****** ***interaction*** , and it may play a role in transferring information between the dystroglycan complex and other signaling pathways .	parallel	1
1287	10098873	2885;1605	Grb2;beta-dystroglycan	At the synapses , the adaptor protein ***Grb2*** may ***mediate*** ***FAK-beta-dystroglycan*** interaction , and it may play a role in transferring information between the dystroglycan complex and other signaling pathways .	target	0
1288	10098873	2885;5747	Grb2;FAK	At the synapses , the adaptor protein ***Grb2*** may ***mediate*** ***FAK-beta-dystroglycan*** interaction , and it may play a role in transferring information between the dystroglycan complex and other signaling pathways .	target	0
1289	10098943	4804;627	p75;neurotrophin	In addition , we used double-label immunohistochemistry to examine colocalization of ER-alpha with the low - and high-affinity ***neurotrophin*** ***receptors*** , ***p75*** and trkA , and with the cholinergic marker choline acetyltransferase .	parallel	1
1290	10098943	4914;627	trkA;neurotrophin	In addition , we used double-label immunohistochemistry to examine colocalization of ER-alpha with the low - and high-affinity ***neurotrophin*** ***receptors*** , p75 and ***trkA*** , and with the cholinergic marker choline acetyltransferase .	parallel	1
1291	10099114	3700;1234	gp120;CCR5	Surface ***CCR5*** could be ***up-regulated*** on the monocytes but not the intestinal macrophages by HIV-1 and ***gp120*** .	positive	1
1292	10099693	133;183	PAMP;angiotensin II	In the adrenal gland both AM and ***PAMP*** ***inhibit*** potassium and ***angiotensin II-stimulated*** aldosterone secretion .	negative	1
1293	10099828	4193;1869	MDM2;E2F1	Because ***MDM2*** also ***binds*** and activates the S phase-specific transcription factor ***E2F1*** , we hypothesized that increased E2F1 activity causes the development of the BLGmdm2 phenotype .	parallel	1
1294	10100098	185;183	AT1;angiotensin II	Activities of the circulating Renin-angiotensin system were measured by radioimmunoassay and the gene expression of tissue angiotensinogen , the ***angiotensin II*** type 1 ***receptor*** ( ***AT1*** ) and fibronectin were analyzed by Northern blot analysis .	parallel	1
1295	10100611	6804;6844	syntaxin 1a;synaptobrevin 2	A stable ***interaction*** between ***syntaxin 1a*** and ***synaptobrevin 2*** mediated by their transmembrane domains .	parallel	1
1296	10100614	1977;1978	eIF-4E;4E-BP1	Incubation of hepatocytes under hypoxia increases ***binding*** of translation initiation factor ***eIF-4E*** to its inhibitory regulator ***4E-BP1*** , and this correlates with dephosphorylation of 4E-BP1 .	parallel	1
1297	10100614	1978;1977	4E-BP1;eIF-4E	This enhanced ***association*** of ***4E-BP1*** with ***eIF-4E*** might be mediated by mTOR .	parallel	0
1298	10100614	2475;1978	mTOR;4E-BP1	This enhanced association of ***4E-BP1*** with eIF-4E might be ***mediated*** by ***mTOR*** .	target	0
1299	10100620	861;2353	acute myeloid leukemia 1;c-fos	***Regulation*** of ***c-fos*** gene transcription and myeloid cell differentiation by ***acute myeloid leukemia 1*** and acute myeloid leukemia-MTG8 , a chimeric leukemogenic derivative of acute myeloid leukemia 1 .	target	1
1300	10100620	862;2353	MTG8;c-fos	***Regulation*** of ***c-fos*** gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid ***leukemia-MTG8*** , a chimeric leukemogenic derivative of acute myeloid leukemia 1 .	target	1
1301	10100620	861;2353	acute myeloid leukemia 1;c-fos	In 32Dcl3 myeloid cells , stable overexpression of ***acute myeloid leukemia 1-MTG8*** ***blocked*** the ***c-fos*** gene transcription and cell differentiation , but that of acute myeloid leukemia did not .	negative	0
1302	10100620	862;2353	MTG8;c-fos	In 32Dcl3 myeloid cells , stable overexpression of ***acute myeloid leukemia 1-MTG8*** ***blocked*** the ***c-fos*** gene transcription and cell differentiation , but that of acute myeloid leukemia did not .	negative	0
1303	10100634	3565;7124	interleukin-4;TNF-alpha	Moreover , this study showed that in vitro treatment of neuroblastoma cells with ***interleukin-4*** ( IL-4 ) , which ***inhibits*** ***TNF-alpha*** production , reduced the expression of the neuronal ELAV-like proteins .	negative	1
1304	10100920	116;7432	pituitary adenylate cyclase-activating polypeptide;VIP	***pituitary adenylate cyclase-activating polypeptide*** ( PACAP ) ***interacts*** with three types of ***PACAP/VIP-receptors*** .	parallel	1
1305	10100924	6750;7124	Somatostatin;TNF-alpha	These findings demonstrate that ***Somatostatin*** and octreotide ***modulate*** the release of nitric oxide , ***TNF-alpha*** and H2O2 by Kupffer cells in cirrhotic livers depending on the concentrations of hormones used .	target	0
1306	10100926	796;2520	calcitonin;gastrin	The aims of the present study were to examine ( 1 ) if ***calcitonin*** ( CT ) , parathyroid hormone ( PTH ) and vitamin D ***affect*** the ***gastrin-ECL-cell*** axis ( by measuring the activity of the histamine-forming enzyme , histidine decarboxylase ( HDC ) , and the expression of HDC mRNA and CGA mRNA in the ECL cells ) , and ( 2 ) if activation of the gastrin-ECL-cell axis affects the parathyroid glands ( by measuring plasma PTH and mRNA expression ) .	target	0
1307	10100926	5741;2520	parathyroid hormone;gastrin	The aims of the present study were to examine ( 1 ) if calcitonin ( CT ) , ***parathyroid hormone*** ( PTH ) and vitamin D ***affect*** the ***gastrin-ECL-cell*** axis ( by measuring the activity of the histamine-forming enzyme , histidine decarboxylase ( HDC ) , and the expression of HDC mRNA and CGA mRNA in the ECL cells ) , and ( 2 ) if activation of the gastrin-ECL-cell axis affects the parathyroid glands ( by measuring plasma PTH and mRNA expression ) .	target	0
1308	10101004	3567;596	IL-5;Bcl-2	This investigation indicates a specific profile of apoptotic molecules in eosinophils distinct from that of neutrophils , and indicates that survival-enhancing ***IL-5*** ***modulates*** the expression of ***Bcl-2*** in vitro .	target	0
1309	10101011	3565;7124	IL-4;TNF-alpha	Interestingly , ***IL-4*** ***synergized*** with ***TNF-alpha*** to increase greatly the production of three biochemically distinct eotaxin forms .	parallel	0
1310	10101011	3565;6356	IL-4;eotaxin	Interestingly , ***IL-4*** synergized with TNF-alpha to ***increase*** greatly the production of three biochemically distinct ***eotaxin*** forms .	positive	0
1311	10101011	3458;7124	IFN-gamma;TNF-alpha	In contrast , ***IFN-gamma*** ***synergized*** with ***TNF-alpha*** to increase RANTES production .	parallel	0
1312	10101017	3977;3976	LIFR;Leukemia inhibitory factor	The distribution and regulation of ***Leukemia inhibitory factor*** ( LIF ) and its ***receptor*** ( ***LIFR*** ) in human lung tissue is unknown .	parallel	1
1313	10101030	196;405	AhR;Arnt	In contrast , ***AhR*** in TCDD-treated cells was primarily immunoprecipitated from nuclear extracts and was ***associated*** with ***Arnt*** but not 90 kDa heat shock protein .	parallel	0
1314	10101031	136;3576	adenosine A2B receptor;IL-8	These results indicate that extracellular adenosine can regulate ERK , c-Jun N-terminal kinase , and p38 MAPK signaling cascades and that activation of ERK and p38 MAPK pathways are essential steps in ***adenosine A2B receptor-dependent*** ***stimulation*** of ***IL-8*** production in HMC-1 .	positive	0
1315	10101129	4617;4654	Myf-5;MyoD	These data support the hypothesis that LS-14 and LS-15 define the core enhancer targets for ***Myf-5-dependent*** ***activation*** of ***MyoD*** in myotomal muscles .	positive	1
1316	10101198	4541;4540	ND6;ND5	The cDNA for the sea urchin mitochondrial D-loop-binding protein ( mtDBP ) , a 40 kDa protein which binds two homologous regions of mitochondrial DNA ( the D-loop region and the ***boundary*** between the oppositely transcribed ***ND5*** and ***ND6*** genes ) , has been cloned .	parallel	0
1317	10101232	4760;203	NeuroD;AK1	The CAT reporter assay of the 5 ' - flanking region of the AK1 gene suggests that ***NeuroD*** ***activates*** the ***AK1*** expression through E-boxes in the promoter region .	positive	1
1318	10101252	5663;1508	PS1;APPs	These results indicate that PKC deficits are unlikely to contribute to increased Abeta seen with APP and PS1 mutations , and also that ***PS1*** mutations ***decrease*** alpha-secretase derived ***APPs*** production independently of altered PKC activity .	positive	0
1319	10101680	940;941	CD28;CD80	***Interaction*** of ***CD28*** with ***CD80*** or CD86 molecules on APC initiates a costimulatory or second signal within the T cell which augments and sustains T cell activation initiated through the TCR .	parallel	1
1320	10101680	940;942	CD28;CD86	***Interaction*** of ***CD28*** with CD80 or ***CD86*** molecules on APC initiates a costimulatory or second signal within the T cell which augments and sustains T cell activation initiated through the TCR .	parallel	1
1321	10102250	3952;6462	leptin;sex hormone-binding globulin	***leptin*** was significantly ***associated*** with fasting insulin in both sexes independent of age , sex hormones , ***sex hormone-binding globulin*** , VAT and SAT .	parallel	0
1322	10102271	146059;8506	DLT;Neurexin IV	At subsequent stages of development , ***DLT*** ***interacts*** with the apical determinant Crumbs ( CRB ) and the laterally localized protein ***Neurexin IV*** ( NRX IV ) .	parallel	1
1323	10102273	207;2309	Akt;FKHRL1	In this study , we demonstrate that ***Akt*** also ***regulates*** the activity of ***FKHRL1*** , a member of the Forkhead family of transcription factors .	target	1
1324	10102273	207;2309	Akt;FKHRL1	In the presence of survival factors , ***Akt*** ***phosphorylates*** ***FKHRL1*** , leading to FKHRL1 's association with 14-3-3 proteins and FKHRL1 's retention in the cytoplasm .	target	1
1325	10102358	983;3320	Cdc2;Hsp90	Genetic interactions were not observed in combination with point mutations in other cdc genes , suggesting that ***Cdc2*** specifically ***interacts*** with ***Hsp90*** .	parallel	1
1326	10102472	3553;5502	IL-1beta;inhibitor-1	The ***activation*** of plasminogen activator ***inhibitor-1*** expression by ***IL-1beta*** is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen receptor alpha .	positive	1
1327	10102566	3952;7351	leptin;UCP2	There was no indication that the expression of ***UCP2*** was markedly ***affected*** by the addition of ***leptin*** , dexamethasone or isoprenaline .	target	0
1328	10102579	5451;4790	Oct-1;NF-kappaB	These data suggest that , besides the NF-kappaB site , the octamer motif is essential for the maximal expression of the iNOS gene in murine macrophages , and the direct ***interaction*** of ***Oct-1*** and ***NF-kappaB*** is important for the regulation of this gene .	parallel	1
1329	10102625	7124;7299	TNFalpha;tyrosinase	First , we show that ***TNFalpha*** ***inhibits*** the activity and protein expression of ***tyrosinase*** which is the key enzyme of melanogenesis .	negative	1
1330	10102627	8061;3725	Fra-1;AP-1	Previously , we have shown that nuclear extracts from cultured mouse keratinocytes induced to differentiate by increasing the levels of extra-cellular calcium contain ***Fra-1*** , Fra-2 , Jun B , Jun D and c-Jun proteins that ***bind*** to the ***AP-1*** DNA binding sequence .	parallel	1
1331	10102627	2355;3725	Fra-2;AP-1	Previously , we have shown that nuclear extracts from cultured mouse keratinocytes induced to differentiate by increasing the levels of extra-cellular calcium contain Fra-1 , ***Fra-2*** , Jun B , Jun D and c-Jun proteins that ***bind*** to the ***AP-1*** DNA binding sequence .	parallel	1
1332	10102627	3725;466	AP-1;ATF-1	***AP-1*** and CRE DNA binding activity ***correlated*** with the induction of CREB , CREMalpha and ***ATF-1*** and CREB phosphorylation at ser133 ( ser133 phospho-CREB ) in the transition from basal to differentiating keratinocytes , but the activity of a CRE reporter remained unchanged .	parallel	0
1333	10102627	3725;1385	AP-1;CREB	***AP-1*** and CRE DNA binding activity ***correlated*** with the induction of ***CREB*** , CREMalpha and ATF-1 and CREB phosphorylation at ser133 ( ser133 phospho-CREB ) in the transition from basal to differentiating keratinocytes , but the activity of a CRE reporter remained unchanged .	parallel	0
1334	10102627	1385;3725	CREB;AP-1	In experiments where the A-CREB mutant was co-transfected with an AP-1 reporter construct , transcriptional activity was also increased indicating that a ***CREB*** family member ***binds*** ***AP-1*** sites and represses AP-1 transcriptional activity as well .	parallel	1
1335	10102627	1385;3725	CREB;AP-1	In experiments where the A-CREB mutant was co-transfected with an AP-1 reporter construct , transcriptional activity was also increased indicating that a ***CREB*** family member binds AP-1 sites and ***represses*** ***AP-1*** transcriptional activity as well .	negative	1
1336	10102631	4301;1499	l-afadin;beta-catenin	Neither ***l-afadin*** nor neurabin-II significantly ***interacted*** with alpha - , ***beta-catenin*** , E-cadherin , ZO-1 or occludin .	parallel	1
1337	10102631	4301;999	l-afadin;E-cadherin	Neither ***l-afadin*** nor neurabin-II significantly ***interacted*** with alpha - , beta-catenin , ***E-cadherin*** , ZO-1 or occludin .	parallel	1
1338	10102631	4301;100506658	l-afadin;occludin	Neither ***l-afadin*** nor neurabin-II significantly ***interacted*** with alpha - , beta-catenin , E-cadherin , ZO-1 or ***occludin*** .	parallel	1
1339	10102631	4301;7082	l-afadin;ZO-1	Neither ***l-afadin*** nor neurabin-II significantly ***interacted*** with alpha - , beta-catenin , E-cadherin , ***ZO-1*** or occludin .	parallel	1
1340	10102631	84687;1499	neurabin-II;beta-catenin	Neither l-afadin nor ***neurabin-II*** significantly ***interacted*** with alpha - , ***beta-catenin*** , E-cadherin , ZO-1 or occludin .	parallel	1
1341	10102631	84687;999	neurabin-II;E-cadherin	Neither l-afadin nor ***neurabin-II*** significantly ***interacted*** with alpha - , beta-catenin , ***E-cadherin*** , ZO-1 or occludin .	parallel	1
1342	10102631	84687;100506658	neurabin-II;occludin	Neither l-afadin nor ***neurabin-II*** significantly ***interacted*** with alpha - , beta-catenin , E-cadherin , ZO-1 or ***occludin*** .	parallel	1
1343	10102631	84687;7082	neurabin-II;ZO-1	Neither l-afadin nor ***neurabin-II*** significantly ***interacted*** with alpha - , beta-catenin , E-cadherin , ***ZO-1*** or occludin .	parallel	1
1344	10102632	7422;3791	VEGF;KDR	***VEGF*** ***binding*** to KDR ( Y951F ) and ***KDR*** ( Y996F ) expressing cells resulted in phosphorylation of all cellular substrates tested , although the level of PLCgamma phosphorylation was decreased for KDR ( Y996F ) .	parallel	1
1345	10102636	7040;4087	TGFbeta;Smad2	***TGFbeta*** binding to heteromeric complexes of transmembrane Ser/Thr kinases ***induces*** ***Smad2*** and Smad3 phosphorylation on their C terminus residues .	target	1
1346	10102636	7040;4088	TGFbeta;Smad3	***TGFbeta*** binding to heteromeric complexes of transmembrane Ser/Thr kinases ***induces*** Smad2 and ***Smad3*** phosphorylation on their C terminus residues .	target	1
1347	10102692	1803;2695	DPP IV;GIP	The formation of ***GIP*** ( 3-42 ) was almost completely ***abolished*** by inhibition of plasma ***DPP IV*** with diprotin A.	positive	0
1348	10102704	7124;7412	TNF-alpha;vascular cell adhesion molecule-1	The augmented TNF-alpha-induced NF-kappaB activation in HG was associated with increased ***TNF-alpha-mediated*** transcriptional ***activation*** of the ***vascular cell adhesion molecule-1*** promoter .	positive	1
1349	10102943	1113;2520	CgA;gastrin	RESULTS : Fasting serum ***CgA*** levels positively ***correlated*** with serum ***gastrin*** in the entire study population ( r = 0 .	positive	0
1350	10102967	2520;6750	gastrin;somatostatin	CONCLUSIONS : Conventional mice with gastric ulcers can be successfully infected by both toxigenic and nontoxigenic H. pylori strains , and this infection causes an immediate suppression of gastric secretion and markedly delays the healing of ulcers due to the fall in mucosal microcirculation in the ulcer region , cytokine release and an impairment in the ******gastrin-somatostatin****** ***link*** that appears to be independent of gastritis and more pronounced with infection of toxigenic than nontoxigenic strains .	parallel	0
1351	10102987	8851;3005	p25;histone H1	Crp is highly related to the mammalian Cdk5 , and ***p25*** ( a truncated form of p35 , the activating subunit of Cdk5 from mammalian brain ) ***stimulates*** the ***histone H1*** kinase activity of GST-Crp by several fold .	positive	0
1352	10103006	2230;1583	adrenodoxin;P450SCC	Because no similar effects were observed in Tween 20 micelles , these results suggest that the phospholipid membrane may play an important role in the ***interaction*** of human ***adrenodoxin*** with human ***P450SCC*** .	parallel	1
1353	10103073	4760;27429	beta2;htra2	***htra2-beta2*** is not translated into protein , and probably helps to ***regulate*** the relative amounts of ***htra2-beta1*** to beta3 .	target	1
1354	1012339	2922;5972	bombesin;renin	***bombesin*** , a tetradecapeptide isolated from the skin of some European discoglossid frogs , has been reported previously to reduce renal blood flow and glomerular filtration rate and to ***increase*** plasma ***renin*** activity in anaesthetized dogs .	positive	0
1355	10168548	4018;338	apo;apoB-100	It consists of one molecule of low density Lipoprotein and an additional molecule of ***apo*** ( a ) ***linked*** to ***apoB-100*** by a disulfide bridge .	parallel	0
1356	10187764	3458;4842	IFNgamma;NOS	Furthermore , LPS plus ***IFNgamma*** ***increased*** the tyrosine phosphorylation of ***NOS-I*** , with a concomitant inhibition of its enzyme activity .	positive	0
1357	10187765	3827;4790	bradykinin;NF-kappaB	Requirement of phosphatidylinositol 3-kinase activity for ***bradykinin*** ***stimulation*** of ***NF-kappaB*** activation in cultured human epithelial cells .	positive	0
1358	10187765	4790;387	NF-kappaB;RhoA	We previously demonstrated that BK-stimulated ***NF-kappaB*** activation ***requires*** the small GTPase ***RhoA*** .	target	0
1359	10187771	8837;841	c-FLIP;caspase-8	We have previously reported on the death effector domain containing E8 gene product from equine herpesvirus-2 , designated FLICE inhibitory protein ( v-FLIP ) , and on its cellular homologue , ***c-FLIP*** , which ***inhibit*** the activation of ***caspase-8*** by death receptors .	negative	1
1360	10187774	7040;94	TGF-beta1;ALK-1	We show that ***TGF-beta1*** and TGF-beta3 , as well as a third unknown ligand present in serum , can ***activate*** chimeric ***ALK-1*** .	positive	1
1361	10187774	7043;94	TGF-beta3;ALK-1	We show that TGF-beta1 and ***TGF-beta3*** , as well as a third unknown ligand present in serum , can ***activate*** chimeric ***ALK-1*** .	positive	1
1362	10187783	10045;5599	NSP1;JNK1	Increased expression of ***NSP1*** in 293 cells ***induces*** activation of ***JNK1*** , but not of ERK2 .	target	1
1363	10187789	10645;8536	CaMKK;CaMKI	Several recent studies have shown that Ca2 + / calmodulin-dependent protein kinase I ( ***CaMKI*** ) is ***phosphorylated*** and activated by a protein kinase ( ***CaMKK*** ) that is itself subject to regulation by Ca2 + / calmodulin .	target	1
1364	10187789	8536;10645	CaMKI;CaMKK	In vitro , ***CaMKK*** is also ***phosphorylated*** by ***CaMKI*** at the same sites as PKA , suggesting that this regulatory phosphorylation might play a role as a negative-feedback mechanism .	target	1
1365	10187797	5606;5594	MKK3;ERK	***MKK3*** and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and MEK1 are upstream ***activators*** of SAPK/JNK and ***ERK*** pathways , respectively .	positive	1
1366	10187797	5606;5599	MKK3;JNK	***MKK3*** and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and MEK1 are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1367	10187797	5606;5601	MKK3;SAPK	***MKK3*** and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and MEK1 are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1368	10187797	5608;5594	MKK6;ERK	MKK3 and ***MKK6*** are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and MEK1 are upstream ***activators*** of SAPK/JNK and ***ERK*** pathways , respectively .	positive	1
1369	10187797	5608;5599	MKK6;JNK	MKK3 and ***MKK6*** are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and MEK1 are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1370	10187797	5608;5601	MKK6;SAPK	MKK3 and ***MKK6*** are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and MEK1 are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1371	10187797	5604;5594	MEK1;ERK	MKK3 and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and ***MEK1*** are upstream ***activators*** of SAPK/JNK and ***ERK*** pathways , respectively .	positive	1
1372	10187797	5604;5599	MEK1;JNK	MKK3 and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and ***MEK1*** are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1373	10187797	5604;5601	MEK1;SAPK	MKK3 and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas SEK1 and ***MEK1*** are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1374	10187797	6416;5594	SEK1;ERK	MKK3 and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas ***SEK1*** and MEK1 are upstream ***activators*** of SAPK/JNK and ***ERK*** pathways , respectively .	positive	1
1375	10187797	6416;5599	SEK1;JNK	MKK3 and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas ***SEK1*** and MEK1 are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1376	10187797	6416;5601	SEK1;SAPK	MKK3 and MKK6 are known potential constituents of p38 MAPK signaling pathway , whereas ***SEK1*** and MEK1 are upstream ***activators*** of ***SAPK/JNK*** and ERK pathways , respectively .	positive	1
1377	10187797	5604;5594	MEK1;p38	We observe that the dominant-negative mutant of MKK3 but not of MKK6 , SEK1 , or ***MEK1*** ***inhibits*** RAFTK-induced ***p38*** MAPK activity .	positive	1
1378	10187797	5606;5594	MKK3;p38	We observe that the dominant-negative mutant of ***MKK3*** but not of MKK6 , SEK1 , or MEK1 ***inhibits*** RAFTK-induced ***p38*** MAPK activity .	positive	1
1379	10187797	6416;5594	SEK1;p38	We observe that the dominant-negative mutant of MKK3 but not of MKK6 , ***SEK1*** , or MEK1 ***inhibits*** RAFTK-induced ***p38*** MAPK activity .	positive	1
1380	10187798	7341;7132	DAP-1;p60	The ubiquitin-homology protein , ***DAP-1*** , ***associates*** with tumor necrosis factor receptor ( ***p60*** ) death domain and induces apoptosis .	parallel	0
1381	10187798	7341;7132	DAP-1;TNF-R1	The in vivo ***interaction*** between ***DAP-1*** and ***TNF-R1*** was further confirmed in mammalian cells .	parallel	1
1382	10187798	7341;4790	DAP-1;NF-kappaB	In transient transfection assays , overexpression of ***DAP-1*** ***suppresses*** ***NF-kappaB/Rel*** activity in 293T cells , a human kidney embryonic carcinoma cell line .	negative	1
1383	10187804	7786;5609	DLK;MKK7	In confirmatory experiments performed in vivo , ***DLK*** both ***associated*** with and activated ***MKK7*** .	parallel	0
1384	10187821	1906;1910	Endothelin-1;ETB	***Endothelin-1*** ***binding*** to the endothelin B receptor ( ***ETB*** ) , a member of the superfamily of G-protein-coupled receptors , was associated with catalytic activation of the extracellular-regulated kinase 2 ( ERK2 ) and stimulation of AP-1 transcriptional reporter activity .	parallel	1
1385	10187833	4803;2353	nerve growth factor;c-fos	In these studies we confirmed that H7 , but not HA1004 , potently blocks the ***induction*** of zif268 and ***c-fos*** mRNA by ***nerve growth factor*** , carbachol , phorbol ester , Ca2 + ionophore , or forskolin .	target	1
1386	10187847	6285;7157	S100B;p53	Calcium-dependent ***interaction*** of ***S100B*** with the C-terminal domain of the tumor suppressor ***p53*** .	parallel	1
1387	10187847	6285;7157	S100B;p53	In vitro , the ***S100B*** protein ***interacts*** with baculovirus recombinant ***p53*** protein and protects p53 from thermal denaturation .	parallel	1
1388	10187852	6464;2885	Shc;Grb2	PKC was required for maximal activation of mitogen-activated kinase kinase 1 , Raf-1 , and Ras , tyrosine phosphorylation of Shc , and ***Shc*** ***association*** with ***Grb2*** .	parallel	0
1389	10187854	4803;4914	NGF;TrkA	***NGF*** ***binds*** to ***TrkA*** , activates the intrinsic kinase activity of TrkA , and promotes the differentiation of pheochromocytoma ( PC12 ) cells into sympathetic-like neurons .	parallel	1
1390	10187854	4803;4914	NGF;TrkA	***NGF*** binds to TrkA , ***activates*** the intrinsic kinase activity of ***TrkA*** , and promotes the differentiation of pheochromocytoma ( PC12 ) cells into sympathetic-like neurons .	positive	1
1391	10187854	4914;6294	TrkA;glutathione S-transferase fusion protein	In contrast , NGF was unable to stimulate the ***association*** of ***TrkA*** with a ***glutathione S-transferase fusion protein*** containing a mutant SH2-Bbeta ( R555E ) with a defective SH2 domain .	parallel	0
1392	10187857	1052;3479	C/EBPdelta;IGF-I	Taken together , our results provide evidence that ***C/EBPdelta*** is a critical ***activator*** of ***IGF-I*** gene transcription in osteoblasts and potentially in other cell types and species .	positive	1
1393	10187857	1052;3479	CCAAT/enhancer-binding protein delta;IGF-I	We previously determined that ***CCAAT/enhancer-binding protein delta*** ( C/EBPdelta ) is the key cAMP-stimulated ***regulator*** of ***IGF-I*** transcription in these cells and showed that it transactivates the rat IGF-I promoter through the HS3D site .	target	1
1394	10187858	10054;7341	SAE2;SUMO-1	In vitro , recombinant SAE1/SAE2 ( SUMO-1-activating enzyme ) was capable of catalyzing the ATP-dependent formation of a thioester ***linkage*** between ***SUMO-1*** and ***SAE2*** .	parallel	0
1395	10187858	7341;4792	SUMO-1;IkappaBalpha	In the presence of SAE1/SAE2 , Ubch9 , and ATP , ***SUMO-1*** was efficiently ***conjugated*** to the protein substrate ***IkappaBalpha*** .	parallel	1
1396	10187861	6885;1147	TAK1;IKKalpha	***TAK1*** ***activated*** ***IKKalpha*** and IKKbeta in the presence of TAB1 .	positive	1
1397	10187861	6885;3551	TAK1;IKKbeta	***TAK1*** ***activated*** IKKalpha and ***IKKbeta*** in the presence of TAB1 .	positive	1
1398	10187861	1147;6885	IKKalpha;TAK1	***IKKalpha*** and IKKbeta were ***coimmunoprecipitated*** with ***TAK1*** in the absence of TAB1 .	parallel	1
1399	10187861	3551;6885	IKKbeta;TAK1	IKKalpha and ***IKKbeta*** were ***coimmunoprecipitated*** with ***TAK1*** in the absence of TAB1 .	parallel	1
1400	10187861	7124;6885	tumor necrosis factor-alpha;TAK1	Furthermore , ***tumor necrosis factor-alpha*** ***activated*** endogenous ***TAK1*** , and the kinase-negative TAK1 acted as a dominant negative inhibitor against tumor necrosis factor-alpha-induced NF-kappaB activation .	positive	1
1401	10187863	836;6610	caspase-3;N-SMase	Moreover , recombinant purified ***caspase-3*** ***increased*** magnesium-dependent ***N-SMase*** in a cell-free system .	positive	0
1402	10188588	3725;2353	Jun;Fos	***Jun*** and ***Fos*** , b-ZIP transcription factors , form a ***heterodimer*** and bind to DNA enhancer elements , thereby regulating the expression of target genes .	parallel	1
1403	10188588	3725;2353	Jun;Fos	The present study was undertaken to investigate the molecular mechanism underlying nuclear translocation of the ******Jun/Fos****** ***complex*** .	parallel	1
1404	10188588	3725;2353	Jun;Fos	The nuclear accumulation of ***Fos*** was markedly ***enhanced*** by the presence of wildtype ***Jun*** , but not by Jun mutants lacking nuclear targeting or zipper dimerization functions , implying that Jun and Fos mutually interact via their leucine zippers and translocate from the cytoplasm to the nucleus using the markedly stronger nuclear localization signal of Jun .	positive	0
1405	10188714	7433;7432	VIPR1;VIP	Each of the 10 cell lines and 86.2 % of cPNET expressed mRNA for ***VIP*** ***receptor*** 1 ( ***VIPR1*** ) compared to 52.9 % of ESFT .	parallel	1
1406	10188725	7124;3569	TNF-alpha;IL-6	***IL-6-promoter*** activity was ***enhanced*** by ***TNF-alpha*** irrespective of the presence of an AP-1 binding site , while the degree of activation differed in the various clones , being most pronounced in the m-175 and m-248 clones .	positive	0
1407	10188961	5368;4987	orphanin FQ;ORL1	For the further elucidation of the central functions of ***nociceptin/orphanin FQ*** ( noc/OFQ ) , the endogenous ***ligand*** of the G protein-coupled opioid receptor-like receptor ***ORL1*** , centrally acting specific antagonists will be most helpful .	parallel	1
1408	10188995	3576;3579	IL-8;CXCR2	IL-8 displaced [ 125I ] - ***IL-8*** ***binding*** to CXCR1 and ***CXCR2*** with pKi values of 8.89 + / -0.05 and 9.27 + / -0.03 , respectively .	parallel	1
1409	10188995	2919;3579	GROalpha;CXCR2	***GROalpha*** , a selective ***CXCR2*** ***ligand*** , had a pKi value of 9.66 + / -0.39 at CXCR2 but a pKi > 8 at CXCR1 .	parallel	1
1410	10189354	4790;330	NF-kappaB;IAP-1	Transfer of IkappaBalpha reduced human IAP-1 mRNA levels , which suggested that ***IAP-1*** is transcriptionally ***regulated*** by ***NF-kappaB*** .	target	1
1411	10189357	183;3569	Angiotensin II;interleukin-6	***Angiotensin II*** ***induces*** ***interleukin-6*** transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors .	target	1
1412	10189392	10544;5624	EPCR;APC	Current studies seek to identify the substrate for the ******APC-EPCR****** ***complex*** as the next step in elucidating the mechanisms by which the protein C pathway modulates the response to injury and inflammation .	parallel	1
1413	10189392	10544;5624	EPCR;protein C	This approach led to the identification of an endothelial cell ***protein C*** ***receptor*** ( ***EPCR*** ) .	parallel	1
1414	10189687	3558;920	IL-2;CD4	Combinations of ***IL-2*** with antiretroviral drug combinations can ***induce*** a significant increase of ***CD4-counts*** .	target	1
1415	10189888	836;835	CPP32;ICH-1	The CPP32-preferential tetrapeptide inhibitor Ac-DEVD-CHO blocked the cleavage of ICH-1 and PARP precursors , suggesting that ***CPP32*** or some other DEVD-sensitive caspase ( s ) is the upstream ***activator*** of ***ICH-1*** .	positive	1
1416	10189892	4193;7157	MDM2;p53	These interactions are not consistent with the well-known role of ***MDM2*** , which acts as a negative ***regulator*** for ***p53*** by inhibiting its function and promoting its rapid degradation .	negative	1
1417	10189892	4193;7157	MDM2;p53	These results suggest that ***MDM2*** may ***regulate*** the expression of ***p53*** in the steady state and in response to E2 in breast cancer cells , and imply a novel and important role of MDM2 during breast carcinogenesis .	target	1
1418	10189892	4193;7157	MDM2;p53	Overexpression of ***MDM2*** in MCF-7 ***promotes*** both growth advantage and ***p53*** accumulation in response to estradiol .	positive	0
1419	10189892	4193;7157	MDM2;p53	Moreover , ***MDM2*** antisense oligonucleotides ***prevented*** E2-induced accumulation of ***p53*** .	negative	0
1420	10189965	7124;356	TNF alpha;Fas ligand	The inflammatory cytokine ***TNF alpha*** ***downregulates*** ***Fas ligand*** expression with an accompanying decrease in EC cytotoxicity toward Fas-bearing cells in co-culture .	negative	1
1421	10189965	7124;356	TNF alpha;Fas ligand	Endothelial ***Fas ligand*** expression in arteries is also ***downregulated*** by the local administration of ***TNF alpha*** , and this correlates with robust mononuclear cell infiltration of the subendothelial space .	negative	1
1422	10190278	4323;4322	MT-MMP;collagenase 3	Gelatinase A , ***collagenase 3*** and gelatinase B may be ***activated*** by ***MT-MMP*** based mechanisms , as evidenced by both biochemical and cell based studies .	positive	1
1423	10190549	2956;4436	hMSH6;hMSH2	Mismatch recognition in human cells is mediated primarily by a ***heterodimer*** of ***hMSH2*** and ***hMSH6*** .	parallel	1
1424	10190694	3458;3627	IFN-gamma;IP-10	***IFN-gamma*** ***induced*** the expression of ***IP-10*** , but not of IL-8 , MCP-1 or RANTES .	target	1
1425	10190694	3458;6347	IFN-gamma;MCP-1	***IFN-gamma*** ***induced*** the expression of IP-10 , but not of IL-8 , ***MCP-1*** or RANTES .	target	1
1426	10190694	3458;6352	IFN-gamma;RANTES	***IFN-gamma*** ***induced*** the expression of IP-10 , but not of IL-8 , MCP-1 or ***RANTES*** .	target	1
1427	10190694	7040;7124	TGF-beta;TNF-alpha	TGF-beta alone had little or no effect on RANTES , MCP-1 and IL-8 expression ; however , ***TGF-beta*** ***synergized*** with ***TNF-alpha*** to enhance MCP-1 expression in both astroglioma cells and primary astrocytes .	parallel	0
1428	10190694	7040;6347	TGF-beta;MCP-1	TGF-beta alone had little or no effect on RANTES , MCP-1 and IL-8 expression ; however , ***TGF-beta*** synergized with TNF-alpha to ***enhance*** ***MCP-1*** expression in both astroglioma cells and primary astrocytes .	positive	0
1429	10190694	7040;3576	TGF-beta;IL-8	An inhibitory effect of ***TGF-beta*** on TNF-alpha and IL-1beta ***induced*** RANTES and ***IL-8*** expression was observed in human astroglioma cells .	target	1
1430	10190694	7040;6352	TGF-beta;RANTES	An inhibitory effect of ***TGF-beta*** on TNF-alpha and IL-1beta ***induced*** ***RANTES*** and IL-8 expression was observed in human astroglioma cells .	target	1
1431	10190694	7040;3553	TGF-beta;IL-1beta	In contrast , ***TGF-beta*** ***enhanced*** TNF-alpha and ***IL-1beta*** induction ofIL-8 production by human astrocytes .	positive	0
1432	10190694	7040;7124	TGF-beta;TNF-alpha	In contrast , ***TGF-beta*** ***enhanced*** ***TNF-alpha*** and IL-1beta induction ofIL-8 production by human astrocytes .	positive	0
1433	10190738	887;2520	CCK-BR;gastrin	The aim of this study was to identify the expression of ***CCK-B/gastrin*** ***receptor*** ( ***CCK-BR*** ) , proG , G-gly and G-NH2 in normal liver and liver tumours .	parallel	1
1434	10190903	958;959	CD40;CD40 ligand	Production of IFN-gamma by NKT cells in response to alpha-GalCer required IL-12 produced by dendritic cells ( DCs ) and direct contact between NKT cells and DCs through ******CD40/CD40 ligand****** ***interactions*** .	parallel	1
1435	10191197	5610;355	PKR;fas	Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase ***PKR*** ***induces*** apoptosis and ***fas*** receptor expression .	target	1
1436	10191262	5170;2185	PDK1;protein kinase B	The PtdIns ( 3,4,5 ) P3-dependent ***activation*** of ***protein kinase B*** ( PKB ) by 3-phosphoinositide-dependent protein kinases-1 and -2 ( ***PDK1*** and PDK2 respectively ) is a key event in mediating the effects of signals that activate PtdIns 3-kinase .	positive	1
1437	10191275	2171;6278	E-FABP;S100A7	These data indicate that formation of the ******E-FABP-S100A7****** ***complex*** and its FA-binding function might be regulated at least by bivalent cations .	parallel	1
1438	10191277	5347;5300	Plk;Pin1	Recent reports have demonstrated that in mammalian cells ***Plk*** is ***associated*** with components of the anaphase-promoting complex and a peptidyl-prolyl isomerase , ***Pin1*** .	parallel	0
1439	10191281	3816;5267	hK1;kallistatin	We have explored in detail the determinants of specificity for the hydrolysis by human tissue kallikrein ( hK1 ) of substrates containing the Phe-Phe amino acid pair , after which ***hK1*** ***cleaves*** ***kallistatin*** ( human kallikrein-binding protein ) , a specific serpin for this protease , as well as somatostatin 1-14 .	target	1
1440	10191281	3816;6750	hK1;somatostatin	We have explored in detail the determinants of specificity for the hydrolysis by human tissue kallikrein ( hK1 ) of substrates containing the Phe-Phe amino acid pair , after which ***hK1*** ***cleaves*** kallistatin ( human kallikrein-binding protein ) , a specific serpin for this protease , as well as ***somatostatin*** 1-14 .	target	1
1441	10191282	335;338	apo;apoB-100	In conclusion , the extensive modification of Lp [ a ] caused by PLA2 digestion had no significant influence on the reactivity of LBS II , which is the domain involved in the ***binding*** of ***apo*** [ a ] to fibrinogen and ***apoB-100*** .	parallel	1
1442	10191293	4353;338	myeloperoxidase;apoB-100	Selective ***modification*** of ***apoB-100*** in the oxidation of low density lipoproteins by ***myeloperoxidase*** in vitro .	target	0
1443	10191393	3569;213	Interleukin-6;albumin	***Interleukin-6*** increased fibrinogen and ***decreased*** ***albumin*** production .	negative	0
1444	1019160	5972;551	renin;ADH	It was shown that intraventricular ***renin*** ***increased*** water intake , blood pressure and ***ADH*** secretion and that these effects were blocked by saralasin .	positive	0
1445	1019160	5972;183	renin;angiotensinogen	These findings indicated an ***interaction*** between injected ***renin*** , brain ***angiotensinogen*** and converting enzyme , resulting in the formation of angiotensin II in physiologically active concentrations .	parallel	1
1446	10192426	94;238	ALK1;ALK	Both large and small cells were reactive with antibody ***ALK1*** , which ***recognizes*** the chimaeric ***NPM-ALK*** protein associated with the t ( 2 ; 5 ) ( p23 ; q35 ) .	target	1
1447	10192426	94;4869	ALK1;NPM	Both large and small cells were reactive with antibody ***ALK1*** , which ***recognizes*** the chimaeric ***NPM-ALK*** protein associated with the t ( 2 ; 5 ) ( p23 ; q35 ) .	target	1
1448	10192442	356;355	FasL;Fas	Three patients with different clinical symptoms of graft-versus-host disease ( GVHD ) who had received donor lymphocyte transfusion ( DLT ) for the treatment of relapsed leukaemia after an allogeneic bone marrow transplantation ( BMT ) from HLA-matched sibling donors were analysed for the presence of soluble FasL ( sFasL ) in the sera and for the expression of the ***Fas*** ***ligand*** ( ***FasL*** ) gene in the peripheral blood mononuclear cells ( PBMNC ) .	parallel	1
1449	10192446	7076;4602	Epo;c-myb	GATA-2 and ***c-myb*** were ***down-regulated*** by ***Epo*** , and GATA-2 was further down-modulated by the inducers .	negative	1
1450	10192446	7076;2624	Epo;GATA-2	***GATA-2*** and c-myb were ***down-regulated*** by ***Epo*** , and GATA-2 was further down-modulated by the inducers .	negative	1
1451	10192446	7076;6886	Epo;SCL	Conversely , ***SCL*** expression was ***up-regulated*** by ***Epo*** and further increased by haemin and delta-ALA .	positive	1
1452	10192457	5054;7448	PAI-1;vitronectin	Furthermore , megakaryocyte maturation may depend on the intact ***vitronectin-integrin*** adhesion system that is ***influenced*** by ***PAI-1*** , thereby proposing a regulatory role for the inhibitor in cellular differentiation .	target	0
1453	10192566	3558;3569	IL-2;IL-6	The cytokines IL-1beta and IL-1 receptor antagonist , ***IL-2*** and IL-2 soluble receptor-alpha , IL-6 and ***IL-6*** soluble ***receptor*** , TNF-alpha and TNF soluble receptor I , and IL10 in drained and systemic blood after major orthopaedic surgery .	parallel	1
1454	10192566	7124;3569	TNF-alpha;IL-6	The cytokines IL-1beta and IL-1 receptor antagonist , IL-2 and IL-2 soluble receptor-alpha , IL-6 and ***IL-6*** soluble ***receptor*** , ***TNF-alpha*** and TNF soluble receptor I , and IL10 in drained and systemic blood after major orthopaedic surgery .	parallel	1
1455	10192749	1071;335	CETP;apo	***CETP*** gene expression is enhanced in hypercholesterolaemia and ***correlates*** with plasma ***apo*** E concentration .	parallel	0
1456	10192772	8829;10371	Neuropilin-1;sema III	***Neuropilin-1*** , a ***sema III*** ***receptor*** , was expressed in injured neurons with projections to the lesion site , in a subpopulation of scar-associated cells and in blood vessels around the scar .	parallel	1
1457	10192772	8829;10371	Neuropilin-1;sema III	The concomitant expression of ***sema III*** and its ***receptor*** ***Neuropilin-1*** in the scar suggests that sema III/Neuropilin-1-mediated mechanisms are involved in CNS scar formation .	parallel	1
1458	10193420	3586;3824	IL-10;CD94	We also show that , in vitro , ***IL-10*** ***up-regulates*** ***CD94*** expression on CD8 + and CD56 + cells obtained from normal individuals , suggesting that the augmented expression observed in HIV-infected individuals could be related to the high levels of IL-10 previously described in HIV-1-infected individuals .	positive	1
1459	10193578	4353;1738	myeloperoxidase;dihydrolipoamide dehydrogenase	***Inactivation*** of myocardial ***dihydrolipoamide dehydrogenase*** by ***myeloperoxidase*** systems : effect of halides , nitrite and thiol compounds .	negative	1
1460	10193678	3082;3082	scatter factor;Hepatocyte growth factor	******Hepatocyte growth factor/scatter factor-GeneGene****** 3 ***signaling*** in neural crest-derived melanocyte development .	parallel	0
1461	10193678	3082;3082	scatter factor;Hepatocyte growth factor	******Hepatocyte growth factor/scatter factor****** ( HGF/SF ) ***signaling*** through the tyrosine-kinase receptor , MET , is capable of promoting the proliferation , increasing the motility , and maintaining high tyrosinase activity and melanin synthesis of melanocytes in vitro .	parallel	0
1462	10193827	3952;7124	leptin;TNF-alpha	In multiple regression analysis , serum ***leptin*** also ***correlated*** to serum ***TNF-alpha*** .	parallel	0
1463	10193871	2688;2691	somatotropin;GHRH	Compounds thought to inhibit hypothalamic somatostatin ( SRIH ) release ( pyridostigmine , arginine , galanin , atenolol ) consistently improve , though do not normalize , the ***somatotropin*** ***response*** to ***GHRH*** in obesity .	parallel	0
1464	10194136	7157;900	p53;cyclin G1	These two new pathways , p53-EF-1 alpha-microtubule-severing ( - distortion of cytoskeleton ) and ******p53-cyclin G1-COXII****** ( - CytC , ATP-caspase-3 activation ) , may ***cooperate*** to induce apoptosis in this cell line .	parallel	0
1465	10194233	3479;3486	IGF-I;IGFBP-3	The findings show that changes in free IGF-I levels are not accounted for by alterations in the total ******IGF-I/IGFBP-3****** ***complex*** or in IGFBP-3 levels and indicate that there are other important determinants of free IGF-I .	parallel	1
1466	10194379	5327;5340	t-PA;Plasmin	Here , we explore a desensitization mechanism of the PAR1 thrombin receptor by anticoagulant proteases and provide an explanation to the enigma of why ***Plasmin/tissue*** plasminogen ***activator*** ( ***t-PA*** ) can both activate and deactivate platelets prior to thrombin treatment .	positive	1
1467	10194407	7040;7076	TGF-beta1;TIMP	We have examined the ***regulation*** of the ***gelatinase/TIMP*** balance by transforming growth factor-beta1 ( ***TGF-beta1*** ) and phorbol myristate acetate ( PMA ) in bovine endothelial cells .	target	1
1468	10194419	7040;7057	TGF-beta1;thrombospondin-1	***TGF-beta1*** strongly ***activated*** the production of ***thrombospondin-1*** and ( alpha ) vbeta3 integrin in a concentration-dependent manner whereas the expression of thyroglobulin was unaffected .	positive	1
1469	10194422	3700;7852	gp120;CXCR4	A CD4-independent ***interaction*** of human immunodeficiency virus-1 ***gp120*** with ***CXCR4*** induces their cointernalization , cell signaling , and T-cell chemotaxis .	parallel	1
1470	10194422	30816;7852	envelope glycoprotein;chemokine receptor	The gp120 ***envelope glycoprotein*** of human immunodeficiency virus-1 ( HIV-1 ) ***interacts*** with the CXCR4 ***chemokine receptor*** , but it is not known whether gp120 activates CXCR4-mediated signaling cascades in the same manner as its natural ligand , SDF1alpha .	parallel	1
1471	10194422	3700;7852	gp120;CXCR4	Under both experimental conditions , the ***interaction*** of ***CXCR4*** and ***gp120*** resulted in their CD4-independent cointernalization .	parallel	1
1472	10194422	3700;7852	gp120;CXCR4	***Binding*** of ***gp120*** to ***CXCR4*** resulted in a CD4-independent phosphorylation of Pyk2 and an induction of chemotactic activity , demonstrating that this interaction has functional consequences .	parallel	1
1473	10194431	3569;3570	IL-6;interleukin-6 receptor	We have recently shown that stimulation of glycoprotein ( gp ) 130 , the membrane-anchored signal transducing receptor component of IL-6 , by a ***complex*** of human soluble ***interleukin-6 receptor*** ( sIL-6R ) and ***IL-6*** ( sIL-6R / IL-6 ) , potently stimulates the ex vivo expansion as well as erythropoiesis of human stem/progenitor cells in the presence of stem cell factor ( SCF ) .	parallel	1
1474	10194437	2056;2549	Epo;GAB1	***Epo-induced*** tyrosine ***phosphorylation*** of ***GAB1*** was also observed in normal human erythroid progenitors isolated from cord blood .	target	1
1475	10194437	1437;2549	Granulocyte-macrophage colony-stimulating factor;GAB1	***Granulocyte-macrophage colony-stimulating factor*** ( GM-CSF ) and thrombopoietin ( TPO ) also ***induced*** the tyrosine phosphorylation of ***GAB1*** in UT-7 cells , indicating that this molecule participates in the signal transduction of several cytokine receptors .	target	1
1476	10194437	7066;2549	thrombopoietin;GAB1	Granulocyte-macrophage colony-stimulating factor ( GM-CSF ) and ***thrombopoietin*** ( TPO ) also ***induced*** the tyrosine phosphorylation of ***GAB1*** in UT-7 cells , indicating that this molecule participates in the signal transduction of several cytokine receptors .	target	1
1477	10194437	2056;2549	Erythropoietin;GAB1	***Erythropoietin*** ***induces*** the tyrosine phosphorylation of ***GAB1*** and its association with SHC , SHP2 , SHIP , and phosphatidylinositol 3-kinase .	target	1
1478	10194437	2056;2549	Epo;GAB1	Indeed , ***Epo*** ***induced*** the transient tyrosine phosphorylation of ***GAB1*** in UT-7 cells .	target	1
1479	10194437	2549;2885	GAB1;GRB2	***GAB1*** was also ***associated*** with the molecular adapter ***GRB2*** in unstimulated cells , and this association dramatically increased after Epo stimulation .	parallel	0
1480	10194441	6814;6810	PSP;syntaxin 4	This platelet Sec1 protein ( ***PSP*** ) ***bound*** to ***syntaxin 4*** and thereby excluded the binding of SNAP-25 with syntaxin 4 , an interaction critical to vesicle docking .	parallel	1
1481	10194442	2056;3717	Epo;Janus Kinase-2	Also , recombinant human ***Epo*** ( rHuEpo ) ***stimulates*** ***Janus Kinase-2*** ( JAK-2 ) phosphorylation , cell proliferation , and matrix metalloproteinase-2 ( MMP-2 ) production in EA.hy926 cells and significantly enhances their differentiation into vascular structures when seeded on Matrigel .	positive	0
1482	10194442	2056;4313	Epo;matrix metalloproteinase-2	Also , recombinant human ***Epo*** ( rHuEpo ) ***stimulates*** Janus Kinase-2 ( JAK-2 ) phosphorylation , cell proliferation , and ***matrix metalloproteinase-2*** ( MMP-2 ) production in EA.hy926 cells and significantly enhances their differentiation into vascular structures when seeded on Matrigel .	positive	0
1483	10194443	2313;2815	Fli-1;glycoprotein IX	***Regulation*** of the megakaryocytic ***glycoprotein IX*** promoter by the oncogenic Ets transcription factor ***Fli-1*** .	target	1
1484	10194443	2313;2815	Fli-1;GPIX	In this study , transient cotransfection of several GPIX promoter/reporter constructs into 293T kidney fibroblasts with a Fli-1 expression vector shows that the oncogenic protein ***Fli-1*** can ***transactivate*** the ***GPIX*** promoter when an intact GPIX Ets site is present .	positive	1
1485	10194443	2313;2815	Fli-1;GPIX	In addition , ***Fli-1*** ***binding*** of the ***GPIX*** Ets site was identified in antibody supershift experiments in nuclear extracts derived from hematopoietic human erythroleukemia cells .	parallel	1
1486	10194443	2313;2811	Fli-1;GPIbalpha	Comparative studies showed that ***Fli-1*** was also able to ***transactivate*** the ***GPIbalpha*** and , to a lesser extent , the GPIIb promoter .	positive	1
1487	10194454	356;355	FasL;Fas	In the present study , we examined the contribution of cytotoxic effector mechanisms , which are mediated by tumor necrosis factor-alpha ( TNF-alpha ) , ***Fas*** ***ligand*** ( ***FasL*** ) , or perforin , to GVHD and GVL effect in a murine BMT model .	parallel	1
1488	10194467	183;5743	Angiotensin II;cyclooxygenase-2	***Angiotensin II*** ***attenuates*** renal cortical ***cyclooxygenase-2*** expression .	negative	0
1489	10194517	3484;5747	IGFBP-1;FAK	We conclude from these data that ***IGFBP-1*** can interact with integrin receptors to ***induce*** ***FAK*** dephosphorylation and subsequently influence attachment and cell death .	target	1
1490	10194520	3952;6774	Leptin;signal transducer and activator of transcription (STAT)3	In the present study , we show that ***Leptin*** ***activates*** a ***signal transducer and activator of transcription (STAT)3*** signalling mechanism in pancreatic islets and in a rat model of the pancreatic beta-cell , RINm5F .	positive	1
1491	10194522	7124;3383	TNF-alpha;ICAM-1	However , ***TNF-alpha*** ( 50 ng/ml ) ***induced*** ***ICAM-1*** mRNA within two hours , peak expression being reached between four and eight hours after initiation of treatment .	target	1
1492	10194549	983;891	CDC2;cyclin B1	Reductions of active ***complex*** and kinase activity of ******CDC2/cyclin B1****** were also observed in the presence of the three drugs .	parallel	1
1493	10194763	2796;2798	GnRH;GnRHR	We suggest that ***GnRH*** ***regulation*** of the ***GnRHR*** gene is partially mediated by an ERK-dependent activation of a canonical AP-1 site located in the proximal promoter of the GnRHR gene .	target	1
1494	10194763	2798;2796	GnRHR;GnRH	Homologous regulation of ***GnRH*** ***receptor*** ( ***GnRHR*** ) gene expression is an established mechanism for controlling the sensitivity of gonadotropes to GnRH .	parallel	1
1495	10194763	2796;2798	GnRH;GnRHR	The present studies were designed to further delineate the molecular mechanisms underlying ***GnRH*** ***regulation*** of ***GnRHR*** gene expression .	target	1
1496	10194764	185;183	AT1;angiotensin II	Determination of peptide contact points in the human ***angiotensin II*** type I ***receptor*** ( ***AT1*** ) with photosensitive analogs of angiotensin II .	parallel	1
1497	10195194	23557;6616	Snapin;SNAP-25	***Binding*** of recombinant ***Snapin-CT*** to ***SNAP-25*** blocked the association of the SNARE complex with synaptotagmin .	parallel	1
1498	10195234	3439;7852	IFN-alpha;CXCR4	***IFN-alpha*** and IFN-gamma also ***inhibited*** ***CXCR4*** gene expression in the promyelocytic cell line U937 , and this inhibition led to a decrease in cell-cell fusion between U937 cells and HeLa-MAGI cells .	negative	1
1499	10195234	3458;7852	IFN-gamma;CXCR4	IFN-alpha and ***IFN-gamma*** also ***inhibited*** ***CXCR4*** gene expression in the promyelocytic cell line U937 , and this inhibition led to a decrease in cell-cell fusion between U937 cells and HeLa-MAGI cells .	negative	1
1500	10195234	7124;7852	TNF-alpha;CXCR4	In U937 cells , ***TNF-alpha*** and phorbol myristate acetate ( PMA ) ***stimulated*** ***CXCR4*** gene transcription ; this effect was reversed with prior treatment of cells with IFN-gamma .	positive	0
1501	10195235	7124;6352	TNF-alpha;RANTES	***TNF-alpha*** levels negatively ***correlated*** with HIV-1 antigen-stimulated ***RANTES*** production ( r = -0.71 ; P = 0.0002 ) and lymphocyte proliferation ( r = -0.37 ; P = 0.09 ) .	negative	0
1502	10195426	3815;2057	c-Kit;erythropoietin receptor	A novel way to induce erythroid progenitor self renewal : ***cooperation*** of ***c-Kit*** with the ***erythropoietin receptor*** .	parallel	0
1503	10195437	728;727	C5aR;C5a	A panel of YSFKPMPLaR analogs with systematic substitutions for Lys68 was evaluated for ***C5a*** ***receptor*** ( ***C5aR*** ) binding affinity and activation in two well-characterized assay systems : human polymorphonuclear leukocytes ( PMNs ) and human fetal artery .	parallel	1
1504	10195568	4254;4233	SCF;c-met	Our present study suggests that stimulation of the HGF/c-met signal is concomitant with ***induction*** of ***c-met*** protein by ***SCF*** .	target	1
1505	10195687	1081;5617	hCG;PRL	The ***hCG*** treatment also ***increased*** the steady state ***PRL*** mRNA levels .	positive	0
1506	10195693	8022;5449	Lhx3;Pit-1	Porcine ***Lhx3*** protein ***interacted*** with ***Pit-1*** protein in solution and also with the LIM domain-binding protein NLI/Lbd1/CLIM .	parallel	1
1507	10195697	6908;8648	TBP;F-SRC-1	In vitro binding assay showed that ***TBP*** and TFIIB ***bound*** to C-terminal half of ***F-SRC-1*** .	parallel	1
1508	10195697	2959;8648	TFIIB;F-SRC-1	In vitro binding assay showed that TBP and ***TFIIB*** ***bound*** to C-terminal half of ***F-SRC-1*** .	parallel	1
1509	10195697	6908;8648	TBP;F-SRC-1	These results suggest that F-SRC-1 can function via both CBP-dependent and independent manners using various sets of activation domains and that direct ***interactions*** between ***F-SRC-1*** and ***TBP*** or TFIIB may not be important for CBP-independent transcription .	parallel	1
1510	10195697	2959;8648	TFIIB;F-SRC-1	These results suggest that F-SRC-1 can function via both CBP-dependent and independent manners using various sets of activation domains and that direct ***interactions*** between ***F-SRC-1*** and TBP or ***TFIIB*** may not be important for CBP-independent transcription .	parallel	1
1511	10195697	2959;6908	TFIIB;TBP	These results suggest that F-SRC-1 can function via both CBP-dependent and independent manners using various sets of activation domains and that direct ***interactions*** between F-SRC-1 and ***TBP*** or ***TFIIB*** may not be important for CBP-independent transcription .	parallel	1
1512	10195897	1147;8517	IKK1;IKKAP1	***IKK1*** ***associated*** with NF-kappaB essential modulator ( ***IKKgamma/IKKAP1*** ) , another component of the IKK complex .	parallel	0
1513	10195897	8517;4790	IKKAP1;NF-kappaB	IKK1 associated with ***NF-kappaB*** essential ***modulator*** ( ***IKKgamma/IKKAP1*** ) , another component of the IKK complex .	target	0
1514	10195925	3569;1401	interleukin-6;C-reactive protein	In this study we have sought ***associations*** of levels of ***C-reactive protein*** and ***interleukin-6*** with measures of obesity and of chronic infection as their putative determinants .	parallel	0
1515	10196135	4905;6295	NSF;arrestin1	We demonstrate that purified recombinant ***beta-arrestin1*** and ***NSF*** ***interact*** in vitro and that these proteins can be coimmunoprecipitated from cells .	parallel	1
1516	10196136	2932;1499	GSK-3beta;beta-catenin	Axin forms a complex with glycogen synthase kinase-3beta ( GSK-3beta ) and beta-catenin and promotes ***GSK-3beta-dependent*** ***phosphorylation*** of ***beta-catenin*** , thereby stimulating the degradation of beta-catenin .	target	1
1517	10196148	5320;6343	PLA2;secretin	Purified porcine pancreatic ***PLA2*** also ***stimulated*** ***secretin*** release concentration-dependently from both STC-1 cells and a mucosal cell preparation enriched in secretin-containing endocrine cells isolated from rat duodenum .	positive	0
1518	10196149	836;4214	caspase-3;MEKK-1	Thus , the ***degradation*** of delta protein kinase C ( PKC ) and ***MEKK-1*** by ***caspase-3*** generates activated fragments corresponding to their catalytic domains , consistent with the observations that both enzymes are important for apoptosis .	negative	1
1519	10196153	3329;3336	GroEL;GroES	The 1:1 ***complex*** of ******GroEL.GroES****** binds with one lysozyme or one dimeric GAPDH folding intermediate to form a stable ternary complex .	parallel	1
1520	10196153	3329;3336	GroEL;GroES	Both complexes of ***GroEL.lysozyme1*** and GroEL.GAPDH2 ***bind*** with one ***GroES*** molecule only at the other end of the GroEL molecule forming a trans ternary complex .	parallel	1
1521	10196159	2978;3000	GCAP-1;RetGC	***GCAP-1*** ***activates*** ***RetGC*** in low Ca2 + and inhibits it in high Ca2 + .	positive	1
1522	10196167	650;2353	Bone morphogenetic protein 2;c-fos	***Bone morphogenetic protein 2*** ***inhibits*** platelet-derived growth factor-induced ***c-fos*** gene transcription and DNA synthesis in mesangial cells .	negative	1
1523	10196167	650;2353	BMP2;c-fos	Furthermore , we demonstrate that ***BMP2*** ***inhibits*** PDGF-induced transcription of ***c-fos*** gene , a natural target of Elk-1 that normally forms a ternary complex that activates the serum response element of the c-fos gene .	negative	1
1524	10196169	7157;5743	p53;Cox-2	The results of this study suggest that ***interactions*** between ***p53*** and ***Cox-2*** could be important for understanding why levels of Cox-2 are undetectable in normal cells and increased in many tumors .	parallel	1
1525	10196169	7157;5743	p53;cyclooxygenase-2	***Inhibition*** of ***cyclooxygenase-2*** gene expression by ***p53*** .	negative	1
1526	10196170	596;4214	Bcl2;MEKK1	Overexpression of anti-apoptotic ***Bcl2*** ***blocked*** ***MEKK1*** and taxol-induced apoptosis but did not block the caspase-dependent cleavage of MEKK1 in response to etoposide .	negative	0
1527	10196178	5879;8685	Rac1;MARCO	Similarly , a dominant-negative mutant of the Rho family GTPase ***Rac1*** partially ***inhibited*** the morphogenic effects of ***MARCO*** in Chinese hamster ovary cells , whereas a dominant-negative form of a related protein , Cdc42 , did not .	positive	1
1528	10196181	185;183	AT1AR;angiotensin II	In this study , we visualize the intracellular trafficking of beta-arrestin2 in response to activation of several distinct GPCRs including the beta2-adrenergic receptor ( beta2AR ) , ***angiotensin II*** type 1A ***receptor*** ( ***AT1AR*** ) , dopamine D1A receptor ( D1AR ) , endothelin type A receptor ( ETAR ) , and neurotensin receptor ( NTR ) .	parallel	1
1529	10196191	5906;2889	Rap1;C3G	H. , Horn , G. , and Wittinghofer , A. ( 1997 ) Oncogene 15 , 845-850 ) prompted us to study possible fundamental differences in the way ***Rap1*** ***interacts*** with ***C3G*** compared with the interaction of Ras with the catalytic domain of the mouse Ras guanine nucleotide exchange factor Cdc25 ( Mm ) .	parallel	1
1530	10196191	5906;2889	Rap1;C3G	These results are discussed in the light of the structure of the Ras-Sos complex and suggest that some important differences in the ***interaction*** of ***Rap1*** with ***C3G*** and Ras with Cdc25 ( Mm ) indeed exist and that marker residues have been identified for the different structural requirements .	parallel	1
1531	10196191	5906;5923	Rap1;Cdc25	These results are discussed in the light of the structure of the Ras-Sos complex and suggest that some important differences in the ***interaction*** of ***Rap1*** with C3G and Ras with ***Cdc25*** ( Mm ) indeed exist and that marker residues have been identified for the different structural requirements .	parallel	1
1532	10196197	6732;373156	SRPK1;GST	Recombinant ***SRPK1*** and SRPK2 ***bound*** to and phosphorylated ***GST-SF2*** / ASF in vitro .	parallel	1
1533	10196197	6732;6426	SRPK1;SF2	Recombinant ***SRPK1*** and SRPK2 ***bound*** to and phosphorylated ***GST-SF2*** / ASF in vitro .	parallel	1
1534	10196197	6733;373156	SRPK2;GST	Recombinant SRPK1 and ***SRPK2*** ***bound*** to and phosphorylated ***GST-SF2*** / ASF in vitro .	parallel	1
1535	10196197	6733;6426	SRPK2;SF2	Recombinant SRPK1 and ***SRPK2*** ***bound*** to and phosphorylated ***GST-SF2*** / ASF in vitro .	parallel	1
1536	10196210	3047;3043	A gamma-globin;beta-globin	***A gamma-globin*** gene with a -161 promoter can competitively ***inhibit*** ***beta-globin*** gene expression .	negative	1
1537	10196218	5741;6550	parathyroid hormone;NHE-3	Dual mechanisms of ***regulation*** of Na/H exchanger ***NHE-3*** by ***parathyroid hormone*** in rat kidney .	target	1
1538	10196222	627;10818	Brain-derived neurotrophic factor;fibroblast growth factor receptor substrate 2	***Brain-derived neurotrophic factor*** ***induces*** phosphorylation of ***fibroblast growth factor receptor substrate 2*** .	target	1
1539	10196222	6464;4915	Shc;TrkB	Expression of mutant TrkB in fibroblasts , where tyrosine 484 was changed to phenylalanine , abrogated ***Shc*** ***association*** with ***TrkB*** , but only attenuated and did not block BDNF-induced phosphorylation of mitogen-activated protein kinase ( MAPK ) .	parallel	0
1540	10196222	4915;6464	TrkB;Shc	Expression of mutant ***TrkB*** in fibroblasts , where tyrosine 484 was changed to phenylalanine , ***abrogated*** ***Shc*** association with TrkB , but only attenuated and did not block BDNF-induced phosphorylation of mitogen-activated protein kinase ( MAPK ) .	negative	0
1541	10196222	627;10818	BDNF;fibroblast growth factor receptor substrate 2	***BDNF*** ***induces*** phosphorylation of ***fibroblast growth factor receptor substrate 2*** ( FRS2 ) in both fibroblasts engineered to express TrkB and human neuroblastoma ( NB ) cells that naturally express TrkB .	target	1
1542	10196222	627;10818	BDNF;FRS2	Additionally , ***BDNF*** ***induces*** phosphorylation of ***FRS2*** in primary cultures of cortical neurons , thus showing that FRS2 is a physiologically relevant substrate of TrkB .	target	1
1543	10196222	10818;4915	FRS2;TrkB	Additionally , BDNF induces phosphorylation of FRS2 in primary cultures of cortical neurons , thus showing that ***FRS2*** is a physiologically relevant ***substrate*** of ***TrkB*** .	parallel	1
1544	10196222	10818;9402	FRS2;growth factor receptor-binding protein	Data are presented demonstrating that BDNF induces ***association*** of ***FRS2*** with ***growth factor receptor-binding protein*** 2 ( GRB2 ) in cortical neurons , fibroblasts , and NB cells , which in turn could activate the RAS/MAPK pathway .	parallel	0
1545	10196222	627;10818	BDNF;FRS2	Data are presented demonstrating that ***BDNF*** ***induces*** association of ***FRS2*** with growth factor receptor-binding protein 2 ( GRB2 ) in cortical neurons , fibroblasts , and NB cells , which in turn could activate the RAS/MAPK pathway .	target	1
1546	10196222	6464;10818	Shc;FRS2	This is not dependent on Shc , since BDNF does not induce ***association*** of ***Shc*** and ***FRS2*** .	parallel	0
1547	10196224	672;5932	BRCA1;CtIP	The ***association*** of ***BRCA1*** with ***CtIP*** was also abrogated in cells treated with DNA-damaging agents including UV , gamma-irradiation , and adriamycin , a response correlated with BRCA1 phosphorylation .	parallel	0
1548	10196224	672;1026	BRCA1;p21	The ***transactivation*** of the ***p21*** promoter by ***BRCA1*** was diminished by expression of exogenous CtIP and CtBP .	positive	1
1549	10196225	8881;3897	Cdc16;Spg1	***Spg1*** is negatively ***regulated*** by Byr4 and ***Cdc16*** , which together form a two-component GTPase-activating protein for the Spg1 GTPase .	negative	1
1550	10196235	4146;3672	CMP;integrin alpha1	The antibody to integrin alpha1 , but not to other subunits , coprecipitated 125I-CMP that was added to MRC5 cell lysates , indicating the ***association*** of ***CMP*** with the ***integrin alpha1*** subunit .	parallel	0
1551	10196238	974;973	Igbeta;Igalpha	Trafficking of the ******Igalpha/Igbeta****** ***heterodimer*** with membrane Ig and bound antigen to the major histocompatibility complex class II peptide-loading compartment .	parallel	1
1552	10196238	973;974	Igalpha;Igbeta	The BCR consists of membrane Ig ( mIg ) and ***Igalpha/Igbeta*** ***heterodimer*** ( ***Igalpha/Igbeta*** ) .	parallel	1
1553	10196238	974;973	Igbeta;Igalpha	The BCR consists of membrane Ig ( mIg ) and ***Igalpha/Igbeta*** ***heterodimer*** ( ***Igalpha/Igbeta*** ) .	parallel	1
1554	10196238	974;973	Igbeta;Igalpha	This suggests that the ******Igalpha/Igbeta****** ***heterodimer*** is involved in BCR-mediated antigen transport through the entire antigen transport pathway .	parallel	1
1555	10196247	1977;2033	CBP;p300	Competition for ******CBP/p300****** ***binding*** by various cellular transcription factors has been suggested as a means of integrating different signalling pathways and may also represent a potential mechanism by which E1A manipulates cell fate .	parallel	1
1556	10196247	7157;4193	p53;MDM2	The CBP TRAM binds p53 sequences targeted by the cellular regulator MDM2 , and we demonstrate that an ******MDM2-p53****** ***interaction*** can be disrupted by the CBP TRAM , leading to stabilization of cellular p53 levels and the activation of p53-dependent transcription .	parallel	1
1557	10196249	10657;5921	Sam68;RasGAP	Here , we report that the RNA-binding and protein-binding protein ***Sam68*** ***associates*** with the p21 ( ras ) GTPase-activating protein ***RasGAP*** .	parallel	0
1558	10196251	3383;3683	CD54;CD11a	Human follicular dendritic cells remain uninfected and capture human immunodeficiency virus type 1 through ******CD54-CD11a****** ***interaction*** .	parallel	1
1559	10196252	6387;7852	SDF-1;CXCR4	The alpha-chemokine ***SDF-1*** ***binds*** ***CXCR4*** , a coreceptor for human immunodeficiency virus type 1 ( HIV-1 ) , and inhibits viral entry mediated by this receptor .	parallel	1
1560	10196254	355;356	Fas;Fas ligand	Three CD4 ( + ) CTL clones were demonstrated to lyse cognate , antigen-presenting target cells by a mechanism that primarily involves perforin , while bystander lysis occurred through ******Fas/Fas ligand****** ***interactions*** .	parallel	1
1561	10196311	3700;1234	gp120;CCR5	This structural information was correlated with the MAbs ' abilities to inhibit ( i ) HIV-1 entry , ( ii ) HIV-1 envelope glycoprotein-mediated membrane fusion , ( iii ) ***gp120*** ***binding*** to ***CCR5*** , and ( iv ) CC-chemokine activity .	parallel	1
1562	10196311	920;1234	CD4;CCR5	Surprisingly , there was no correlation between the ability of a MAb to inhibit HIV-1 fusion-entry and its ability to inhibit either the ***binding*** of a gp120-soluble ***CD4*** complex to ***CCR5*** or CC-chemokine activity .	parallel	1
1563	10196356	4792;4790	IkappaBalpha;NF-kappaB	Incomplete ***regulation*** of ***NF-kappaB*** by ***IkappaBalpha*** during respiratory syncytial virus infection in A549 cells .	target	1
1564	10196372	10724;3073	beta-hexosaminidase;hexosaminidase A	The severe neurodegenerative disorder , Tays-Sachs disease , is caused by a ***beta-hexosaminidase*** alpha-subunit deficiency which ***prevents*** the formation of lysosomal heterodimeric alpha-beta enzyme , ***hexosaminidase A*** ( HexA ) .	positive	0
1565	10196481	8600;4982	osteoclast differentiation factor;osteoclastogenesis inhibitory factor	***osteoclast differentiation factor*** ( ODF ) , a ***ligand*** for ***osteoclastogenesis inhibitory factor*** ( OCIF ) / osteoprotegerin ( OPG ) , is a member of the membrane-associated tumor necrosis factor ( TNF ) family and induces osteoclast-like cell formation in vitro .	parallel	1
1566	10196543	3778;57582	Slo;Slack	Formation of intermediate-conductance calcium-activated potassium channels by ***interaction*** of ***Slack*** and ***Slo*** subunits .	parallel	1
1567	10196543	3778;57582	Slo;Slack	Our findings indicate that some intermediate-conductance channels in the nervous system may result from an ***interaction*** between ***Slack*** and ***Slo*** channel subunits .	parallel	1
1568	10196546	7869;10371	SemA;SemD	***SemA*** and SemE ***block*** ***SemD*** binding to NP-1 and abolish SemD repulsion in axons expressing NP-1 .	negative	0
1569	10196546	10512;10371	SemE;SemD	SemA and ***SemE*** ***block*** ***SemD*** binding to NP-1 and abolish SemD repulsion in axons expressing NP-1 .	negative	0
1570	10196712	6445;1756	gamma-SG;dystrophin	Based on the pattern of distribution of the SG proteins in patients with LGMD2C and 2D , and on the observed decreased abundance of dystrophin through WB in some sarcoglycans ( SG ) patients , we have recently suggested that alpha , beta and delta subunits of sarcoglycan complex might be more closely associated and that ***gamma-SG*** might ***interact*** more directly with ***dystrophin*** .	parallel	1
1571	10196712	6445;1756	gamma-SG;dystrophin	These two patients represent further evidence of a closer relation of alpha , beta and delta-SG than of gamma-SG and of the possible ***association*** of ***gamma-SG*** with ***dystrophin*** .	parallel	0
1572	10197222	3827;6863	bradykinin;neurokinin A	Angiotensin-converting enzyme ( ACE ) ***inactivates*** ***bradykinin*** , substance P and ***neurokinin A*** , which are believed to play important roles in the pathogenesis of asthma , especially in neurogenic inflammation .	negative	1
1573	10197222	6863;3827	neurokinin A;bradykinin	Angiotensin-converting enzyme ( ACE ) ***inactivates*** ***bradykinin*** , substance P and ***neurokinin A*** , which are believed to play important roles in the pathogenesis of asthma , especially in neurogenic inflammation .	negative	1
1574	10197222	1636;3827	ACE;bradykinin	Angiotensin-converting enzyme ( ***ACE*** ) ***inactivates*** ***bradykinin*** , substance P and neurokinin A , which are believed to play important roles in the pathogenesis of asthma , especially in neurogenic inflammation .	negative	1
1575	10197222	1636;6863	ACE;neurokinin A	Angiotensin-converting enzyme ( ***ACE*** ) ***inactivates*** bradykinin , substance P and ***neurokinin A*** , which are believed to play important roles in the pathogenesis of asthma , especially in neurogenic inflammation .	negative	1
1576	10197373	3558;1234	IL-2;CCR-5	***IL-2*** treatment also ***increased*** the function of ***CCR-5*** in TH cells .	positive	0
1577	10197585	2308;5077	FKHR;PAX3	In addition to functional alterations , our studies demonstrated ***PAX3-FKHR*** and PAX7-FKHR overexpression resulting from two distinct mechanisms , ***increased*** transcription of ***PAX3-FKHR*** by a copy number-independent mechanism , and gene amplification of PAX7-FKHR .	positive	0
1578	10197585	5077;2308	PAX3;FKHR	In addition to functional alterations , our studies demonstrated ***PAX3-FKHR*** and PAX7-FKHR overexpression resulting from two distinct mechanisms , ***increased*** transcription of ***PAX3-FKHR*** by a copy number-independent mechanism , and gene amplification of PAX7-FKHR .	positive	0
1579	10197585	5081;2308	PAX7;FKHR	In addition to functional alterations , our studies demonstrated PAX3-FKHR and ***PAX7-FKHR*** overexpression resulting from two distinct mechanisms , ***increased*** transcription of ***PAX3-FKHR*** by a copy number-independent mechanism , and gene amplification of PAX7-FKHR .	positive	0
1580	10197585	5081;5077	PAX7;PAX3	In addition to functional alterations , our studies demonstrated PAX3-FKHR and ***PAX7-FKHR*** overexpression resulting from two distinct mechanisms , ***increased*** transcription of ***PAX3-FKHR*** by a copy number-independent mechanism , and gene amplification of PAX7-FKHR .	positive	0
1581	10197592	675;672	BRCA2;BRCA1	The ******BRCA1/BRCA2****** ***complex*** may function in postreplicational repair processes activated during the DNA synthesis stage of the cell cycle .	parallel	1
1582	10197631	7471;1499	Wnt-1;beta-catenin	***Wnt-1*** expression in the mouse mammary epithelial cell lines RAC311 and C57MG ***induces*** stabilization of cytosolic ***beta-catenin*** and morphological transformation .	target	1
1583	10197640	7077;4313	tissue inhibitor of metalloproteinase-2;MMP-2	Divalent ligation of beta1 integrins with soluble P4C10 antibodies stimulated expression of ***pro-MMP-2*** and its ***inhibitor*** , ***tissue inhibitor of metalloproteinase-2*** , whereas soluble 21C8 antibodies had no effect .	negative	1
1584	10197640	4323;4313	MT1-MMP;MMP-2	Aggregation of beta1 integrins with immobilized 21C8 or P4C10 antibodies stimulated MMP-dependent pro-MMP-2 activation and accumulation of a M ( r ) 43,000 form of membrane type 1 MMP ( ***MT1-MMP*** ) , a cell surface ***activator*** of ***pro-MMP-2*** , in cell extracts .	positive	1
1585	10197763	1113;4803	chromogranin a;Nerve growth factor	By contrast , the ***response*** of ***chromogranin a*** to ***Nerve growth factor*** was not impaired after blockade of phospholipase C-gamma or phosphoinositide-3 kinase .	parallel	0
1586	10197763	4803;1113	Nerve growth factor;chromogranin a	Chemical blockade of TrkA , Ras , MEK or mitogen-activated protein kinase similarly inhibited ***Nerve growth factor*** ***activation*** of ***chromogranin a*** .	positive	1
1587	10197763	4803;1113	Nerve growth factor;chromogranin a	***Nerve growth factor*** ***activated*** ***chromogranin a*** gene expression 7.6-fold in PC12 pheochromocytoma cells , and similarly activated PC12-transfected mouse , rat or human chromogranin a promoter/reporter constructs .	positive	1
1588	10197820	348;351	ApoE;Abeta	We hypothesize that ***Abeta*** accumulation is ***triggered*** by ***ApoE*** , which may bind and immobilize soluble Abeta produced in SMCs .	positive	0
1589	10197981	7040;4087	TGFbeta;Smad2	Our results suggest a mechanism for the counterbalanced ***regulation*** of ***Smad2/Smad3*** by ***TGFbeta*** and Ras signals in normal cells , and for the silencing of antimitogenic TGFbeta functions by hyperactive Ras in cancer cells .	target	1
1590	10197981	7040;4088	TGFbeta;Smad3	Our results suggest a mechanism for the counterbalanced ***regulation*** of ***Smad2/Smad3*** by ***TGFbeta*** and Ras signals in normal cells , and for the silencing of antimitogenic TGFbeta functions by hyperactive Ras in cancer cells .	target	1
1591	10197985	26823;26824	U12;U11	These results argue that intron recognition in the U12-dependent splicing pathway is carried out by a single ******U11/U12****** di-snRNP ***complex*** , suggesting greater rigidity in the intron recognition process than in the major spliceosome .	parallel	1
1592	10198041	11200;7465	Cds1;Wee1	***Cds1*** is proposed to ***regulate*** ***Wee1*** and Mik1 , two tyrosine kinases that inhibit the mitotic kinase Cdc2 .	target	1
1593	10198041	11200;995	Cds1;Cdc25	Here , we present evidence from in vivo and in vitro studies , which indicates that ***Cds1*** also ***inhibits*** ***Cdc25*** , the phosphatase that activates Cdc2 .	negative	1
1594	10198041	995;983	Cdc25;Cdc2	Cds1 also inhibited ***Cdc25-dependent*** ***activation*** of ***Cdc2*** in vitro .	positive	1
1595	10198041	11200;983	Cds1;Cdc2	***Cds1*** also ***inhibited*** Cdc25-dependent activation of ***Cdc2*** in vitro .	negative	1
1596	10198041	1111;995	Chk1;Cdc25	***Chk1*** , a protein kinase that is required for the G2-M damage checkpoint that prevents mitosis while DNA is being repaired , also ***inhibited*** ***Cdc25*** in the in vitro assay .	negative	1
1597	10198043	6347;3689	monocyte chemotactic protein-1;LFA-1	In contrast , staining for an activation epitope revealed a rapid and transient ***up-regulation*** of ***LFA-1*** activity by ***monocyte chemotactic protein-1*** ( MCP-1 ) in monocytes and Jurkat CCR2 chemokine receptor transfectants or by stromal-derived factor-1alpha in Jurkat cells .	positive	1
1598	10198169	9572;5914	NR1D1;RARA	Since previous results indicate that the ***THRA/NR1D1*** locus is also ***linked*** to the ***RARA*** gene , these results suggest that the two receptor gene clusters were generated by a single large-scale duplication .	parallel	0
1599	10198169	7067;5914	THRA;RARA	Since previous results indicate that the ***THRA/NR1D1*** locus is also ***linked*** to the ***RARA*** gene , these results suggest that the two receptor gene clusters were generated by a single large-scale duplication .	parallel	0
1600	10198187	3315;5594	hsp27;p38	Small heat shock proteins ( hsp ) have been implicated in mediation of classic preconditioning in the rabbit , ***hsp27*** is a terminal ***substrate*** of the ***p38*** MAPK cascade .	parallel	1
1601	10198191	3553;3791	IL-1 beta;KDR	These findings indicate that cardiac ***VEGF-KDR*** / flk-1 system is ***upregulated*** by ***IL-1 beta*** via activation of tyrosine kinases , suggesting that the IL-1 beta-modulated autocrine and/or paracrine system of VEGF has an important role in the process of angiogenesis in ischemic hearts .	positive	1
1602	10198191	3553;7422	IL-1 beta;VEGF	These findings indicate that cardiac ***VEGF-KDR*** / flk-1 system is ***upregulated*** by ***IL-1 beta*** via activation of tyrosine kinases , suggesting that the IL-1 beta-modulated autocrine and/or paracrine system of VEGF has an important role in the process of angiogenesis in ischemic hearts .	positive	1
1603	10198191	3791;7422	flk-1;vascular endothelial growth factor	Interleukin-1 beta upregulates cardiac expression of ***vascular endothelial growth factor*** and its ***receptor*** ***KDR/flk-1*** via activation of protein tyrosine kinases .	parallel	1
1604	10198191	3553;3791	Interleukin-1 beta;flk-1	***Interleukin-1 beta*** ***upregulates*** cardiac expression of vascular endothelial growth factor and its receptor ***KDR/flk-1*** via activation of protein tyrosine kinases .	positive	1
1605	10198191	3553;7422	Interleukin-1 beta;vascular endothelial growth factor	***Interleukin-1 beta*** ***upregulates*** cardiac expression of ***vascular endothelial growth factor*** and its receptor KDR/flk-1 via activation of protein tyrosine kinases .	positive	1
1606	10198191	3553;7422	IL-1 beta;VEGF	To explore the possible ***regulation*** of the ***VEGF*** system by ***IL-1 beta*** in the heart , we examined the regulation of expression of VEGF and KDR/flk-1 ( one of the VEGF receptors ) by IL-1 beta using cardiac myocytes and cardiac microvascular endothelial cells ( CMEC ) .	target	1
1607	10198191	3553;7422	IL-1 beta;VEGF	Both cardiac myocytes and CMEC substantially expressed ***VEGF*** mRNA and its expression was ***increased*** 3.6 - and 2.4-fold by ***IL-1 beta*** , respectively .	positive	0
1608	10198191	3553;7422	IL-1 beta;VEGF	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein , whereas inhibition of protein kinase C ( PKC ) by staurosporin , calphostin C and phorbol ester-induced PKC depletion , and intracellular Ca2 + chelators did not affect the ***induction*** of ***VEGF*** mRNA by ***IL-1 beta*** .	target	1
1609	10198220	1906;3565	endothelin-1;interleukin-4	We investigated the effect of chronic alcohol ingestion on buccal mucosal ulcer healing by analyzing the ***interplay*** between mucosal expression of tumor necrosis factor-alpha ( TNF-alpha ) , ***endothelin-1*** ( ET-1 ) , and ***interleukin-4*** ( IL-4 ) .	parallel	1
1610	10198224	4790;3383	NF-kappaB;ICAM-1	These findings indicate that NO up-regulates ICAM-1 expression on cancer cells by a regulatory mechanism involving PKC and suggest that ***NF-kappaB*** , but not AP-1 , might be involved in ***induction*** of ***ICAM-1*** by NO in cancer cells .	target	1
1611	10198225	3717;3595	Jak2;interleukin-12 receptor beta 2	Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase : ***Jak2*** ***associates*** with cytoplasmic membrane-proximal region of ***interleukin-12 receptor beta 2*** via amino-terminus .	parallel	0
1612	10198225	3717;3595	Jak2;interleukin-12 receptor beta 2	Physical ***interaction*** between ***interleukin-12 receptor beta 2*** subunit and ***Jak2*** tyrosine kinase : Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus .	parallel	1
1613	10198245	3553;5743	IL-1beta;COX-2	The cytokine ***IL-1beta*** and to a lesser extent EGF , ***enhanced*** ***COX-2*** mRNA levels in gingival fibroblasts .	positive	0
1614	10198245	3553;5742	IL-1beta;COX-1	Neither IL-1beta EGF nor the combination of ***IL-1beta*** and EGF ***enhanced*** ***COX-1*** mRNA levels in gingival fibroblasts .	positive	0
1615	10198256	699;8379	BUB1;MAD1	***Phosphorylation*** of human ***MAD1*** by the ***BUB1*** kinase in vitro .	target	1
1616	10198256	9184;699	BUB3;BUB1	In vitro , ***BUB1*** and ***BUB3*** proteins form a ***complex*** of monomers of each protein .	parallel	1
1617	10198263	3458;3683	Interferon-gamma;CD11a	***Interferon-gamma*** , bacterial lipopolysaccharide , and tumor necrosis factor-alpha ***induce*** ***CD11a*** mRNA and protein via Na + / H + exchange and protein kinase C-dependent mechanisms in tissue macrophages .	target	1
1618	10198263	7124;3683	tumor necrosis factor-alpha;CD11a	Interferon-gamma , bacterial lipopolysaccharide , and ***tumor necrosis factor-alpha*** ***induce*** ***CD11a*** mRNA and protein via Na + / H + exchange and protein kinase C-dependent mechanisms in tissue macrophages .	target	1
1619	10198263	3458;3683	Interferon-gamma;CD11a	Previously ***CD11a*** or leukocyte function-associated antigen alpha-1 was found to be ***induced*** at the surface protein level in thioglycolate-elicited peritoneal macrophages by bacterial lipopolysaccharide and ***Interferon-gamma*** .	target	1
1620	10198263	3458;3683	Interferon-gamma;CD11a	***CD11a*** ***induction*** by ***Interferon-gamma*** conversely is sensitive to inhibition of Na + / H + exchange and insensitive to inhibition of protein kinase C.	target	1
1621	10198298	3458;4843	IFN-gamma;iNOS	However , when used in combination , TNF-alpha , ***IFN-gamma*** , and LPS markedly and synergistically ***increased*** ***iNOS*** activity in these cells .	positive	0
1622	10198298	7124;4843	TNF-alpha;iNOS	However , when used in combination , ***TNF-alpha*** , IFN-gamma , and LPS markedly and synergistically ***increased*** ***iNOS*** activity in these cells .	positive	0
1623	10198344	5578;2822	PKC-alpha;PLD	Taken together , these observations indicate that ***PKC-alpha*** is intimately involved in the ***stimulation*** of ***PLD*** in Caco-2 cells by 1,25 ( OH ) 2D3 or TPA .	positive	0
1624	10198346	1392;3383	CRF;ICAM-1	Intracisternal injection of ***CRF*** ***abrogated*** both the increased expression of ***ICAM-1*** and leukocyte recruitment .	negative	0
1625	10198357	3596;3553	IL-13;IL-1beta	Interleukin ( IL ) -4 and ***IL-13*** dramatically ***enhanced*** the expression of 15-LO , whereas tumor necrosis factor-alpha , ***IL-1beta*** , and interferon ( IFN ) - gamma had no effect .	positive	0
1626	10198357	3596;7124	IL-13;tumor necrosis factor-alpha	Interleukin ( IL ) -4 and ***IL-13*** dramatically ***enhanced*** the expression of 15-LO , whereas ***tumor necrosis factor-alpha*** , IL-1beta , and interferon ( IFN ) - gamma had no effect .	positive	0
1627	10198359	6667;1181	Sp1;ClC-2	This work suggests that ***Sp1*** and Sp3 ***activate*** ***ClC-2*** gene transcription and that reduction in Sp1 and Sp3 at birth explains perinatal downregulation of ClC-2 in the lung .	positive	1
1628	10198359	6670;1181	Sp3;ClC-2	This work suggests that Sp1 and ***Sp3*** ***activate*** ***ClC-2*** gene transcription and that reduction in Sp1 and Sp3 at birth explains perinatal downregulation of ClC-2 in the lung .	positive	1
1629	10198420	1051;4843	C/EBPbeta;NOS2	In trans-activation assays , overexpression of ***C/EBPbeta*** ***stimulated*** basal ***NOS2*** promoter activity .	positive	0
1630	10198433	836;142	caspase-3;PARP	We have demonstrated that particular nucleases of this type are inhibited by poly ( ADP-ribosyl ) ation and suggested that subsequent ***cleavage*** of ***PARP*** by ***caspase-3*** might release these nucleases from poly ( ADP-ribosyl ) ation-induced inhibition .	target	1
1631	10198732	7422;5241	VEGF;progesterone receptor	***VEGF*** was positively associated with age and was inversely ***associated*** with estrogen receptor and ***progesterone receptor*** , whereas TP was not associated with any other variable .	negative	0
1632	10198817	4803;3725	NGF;c-Jun	In this report , we will focus on an ***interaction*** of nerve growth factor ( ***NGF*** ) with the transcription factor ***c-Jun*** in intact and axotomized septohippocampal projection neurons .	parallel	1
1633	1019918	5741;2520	parathyroid hormone;gastrin	***Stimulation*** of ***gastrin*** secretion by ***parathyroid hormone*** .	positive	0
1634	10199400	4089;4087	Smad4;Smad2	Thus , upon entering the nucleus , a ******Smad2-Smad4****** ***complex*** may interact with coactivators , forming a transcriptional activation complex , or with TGIF and HDACs , forming a transcriptional repressor complex .	parallel	1
1635	10199562	3552;5743	Interleukin-1 alpha;cyclooxygenase-2	***Interleukin-1 alpha*** ***induced*** ***cyclooxygenase-2*** expression in bone-derived endothelial cells .	target	1
1636	10199562	3552;5743	IL-1alpha;COX-2	A transcriptional activation assay revealed that the treatment with IL-1alpha increased COX-2 promoter activity in a dose-dependent manner , and ***IL-1alpha*** ***promoted*** ***COX-2*** protein expression in BDECs .	positive	0
1637	10199789	7349;5443	Urocortin;ACTH	A dose-related increase of trophoblast ***ACTH*** or PGE2 was ***induced*** by ***Urocortin*** , whereas astressin inhibited Urocortin-stimulated ACTH or PGE2 release .	target	1
1638	10199789	7349;5443	Urocortin;ACTH	The present study showed that human ***Urocortin*** ***stimulates*** placental secretion of ***ACTH*** and PGE2 , and modulates myometrial contractility , suggesting a role for this peptide in placental and intrauterine CRF pathways .	positive	0
1639	10199789	7349;5443	Urocortin;adrenocorticotropin	***Urocortin*** ***stimulates*** placental ***adrenocorticotropin*** and prostaglandin release and myometrial contractility in vitro .	positive	0
1640	10199811	2321;7422	Flt-1;VEGF	Treatment with either hypoxia or VEGF under normoxic conditions induced a twofold increase in VEGF binding sites and ***VEGF*** ***receptor*** 1 ( ***Flt-1*** ) mRNA expression in BMEC .	parallel	1
1641	10199915	5970;4790	p65;p50	The predominant form of NF-kappaB is a ******p50/p65****** ***heterodimer*** which can be released from IkappaB-alpha and migrate to the nucleus .	parallel	1
1642	10199918	6768;2313	Prss14;Fli1	This gene , ***Prss14*** ( protease , serine , 14 ) , was mapped to mouse chromosome 9 and is closely ***linked*** to the ***Fli1*** ( Friend leukemia integration 1 ) gene .	parallel	0
1643	10199952	1105;6749	CHD1;SSRP1	***CHD1*** ***interacts*** with ***SSRP1*** and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin .	parallel	1
1644	10199952	1105;6749	CHD1;SSRP1	We also present evidence for an in vivo ***interaction*** between ***CHD1*** and a novel HMG box-containing protein , ***SSRP1*** , which involves an amino-terminal segment of CHD1 that does not include the chromodomain .	parallel	1
1645	10199962	3238;6469	Hoxd-12;Sonic hedgehog	This approach has recently revealed that ***Hoxd-12*** can ***induce*** ***Sonic hedgehog*** and suggests a new role for certain 5 ' Hoxd genes in the initiation of Sonic hedgehog expression and its maintenance through feedback regulation .	target	1
1646	10200255	965;914	CD58;CD2	The ***binding*** of the cell surface molecule ***CD58*** ( formerly lymphocyte function-associated antigen 3 ) to its ligand , ***CD2*** , significantly increases the sensitivity of antigen recognition by T cells .	parallel	1
1647	10200259	10537;4085	FAT10;MAD2	A MHC-encoded ubiquitin-like protein ( ***FAT10*** ) ***binds*** noncovalently to the spindle assembly checkpoint protein ***MAD2*** .	parallel	1
1648	10200259	10537;4085	FAT10;MAD2	Yeast two-hybrid screening of a human lymphocyte library and immunoprecipitation studies revealed that ***FAT10*** noncovalently ***associated*** with ***MAD2*** , a protein implicated in a cell-cycle checkpoint for spindle assembly during anaphase .	parallel	0
1649	10200280	2475;5524	FRAP;PP2A	***FRAP*** also is shown to ***phosphorylate*** ***PP2A*** in vitro , consistent with a model in which phosphorylation of PP2A by FRAP prevents the dephosphorylation of 4E-BP1 and p70 ( s6k ) , whereas amino acid deprivation or rapamycin treatment inhibits FRAP 's ability to restrain the phosphatase .	target	1
1650	10200280	2475;5524	FRAP;PP2A	FRAP also is shown to phosphorylate PP2A in vitro , consistent with a model in which ***phosphorylation*** of ***PP2A*** by ***FRAP*** prevents the dephosphorylation of 4E-BP1 and p70 ( s6k ) , whereas amino acid deprivation or rapamycin treatment inhibits FRAP 's ability to restrain the phosphatase .	target	1
1651	10200280	5524;1978	PP2A;4E-BP1	FRAP also is shown to phosphorylate PP2A in vitro , consistent with a model in which phosphorylation of ***PP2A*** by FRAP ***prevents*** the dephosphorylation of ***4E-BP1*** and p70 ( s6k ) , whereas amino acid deprivation or rapamycin treatment inhibits FRAP 's ability to restrain the phosphatase .	negative	0
1652	10200298	4915;7422	trkB;vascular endothelial growth factor	In a cell culture model of MTC , exogenous ***trkB*** expression resulted in severely impaired tumorigenicity and was ***associated*** with 11-fold lower levels of the angiogenesis factor ***vascular endothelial growth factor*** .	parallel	0
1653	10200336	1026;1017	p21;Cdk2	The increased levels of ***p21*** were ***associated*** with increased binding of p21 and ***Cdk2*** concomitant with marked decrease in Cdk2 and cyclin E-dependent kinase activities with no changes in Cdk2 and cyclin E expression .	parallel	0
1654	10200342	7852;6387	CXCR4;hIRH	In HCV liver biopsies , the expression of ***hIRH*** and its ***receptor*** ***CXCR4*** mRNA , corrected for G3PDH , was not significantly different from that of control non-HCV ( steatosis ) biopsies .	parallel	1
1655	10200473	8772;841	FADD;caspase-8	Usurpin heterodimerized with pro-caspase-8 in vitro and precluded ***pro-caspase-8*** ***recruitment*** by the ***FADD/MORT1*** adapter protein .	target	0
1656	10200483	4804;627	p75NTR;neurotrophin	The p75 ***neurotrophin*** ***receptor*** ( ***p75NTR*** ) and trkA , trkB and trkC mediate the physiological effects of the neurotrophins .	parallel	1
1657	10200513	7157;355	p53;APO-1	It has been reported that ***p53*** ***upregulates*** ***Fas/APO-1*** and Bax expression .	positive	1
1658	10200513	7157;581	p53;Bax	It has been reported that ***p53*** ***upregulates*** Fas/APO-1 and ***Bax*** expression .	positive	1
1659	10200513	7157;355	p53;APO-1	However , elevated ***p53*** protein is not sufficient to ***activate*** ***Fas/APO-1*** gene expression in ara-C-treated cells .	positive	1
1660	10200535	993;1017	cdc25A;cdk2	***cdc25A*** tyrosine phosphatase is an ***activator*** of the ***cdk2-cyclin*** E complex which allows for cell cycle progression .	positive	1
1661	10200551	3558;596	IL-2;Bcl-2	Moreover , the addition of exogenous ***IL-2*** , in the presence of Dex , fails to ***up-regulate*** ***Bcl-2*** expression and to revert Dex-mediated apoptotic phenomena .	positive	1
1662	10200558	10015;85365	Alix;ALG-2	******ALG-2/Alix****** ***interaction*** was also validated by co-immunoprecipitation , but in this case , the binding was found to be strictly calcium dependent .	parallel	1
1663	10200559	8743;5599	TRAIL;JNK	We report here that ***JNK/SAPKs*** are ***activated*** by ***TRAIL*** in parallel to induction of apoptosis in human T and B cell lines .	positive	1
1664	10200559	8743;5599	TRAIL;JNK	Death signaling as well as ***JNK/SAPK*** ***activation*** by ***TRAIL*** in these cells is FADD - and caspase-dependent since dominant-negative FADD or the caspase inhibitor zVAD prevented both , apoptosis and JNK/SAPK activity .	positive	1
1665	10200559	8743;5601	TRAIL;SAPK	Death signaling as well as ***JNK/SAPK*** ***activation*** by ***TRAIL*** in these cells is FADD - and caspase-dependent since dominant-negative FADD or the caspase inhibitor zVAD prevented both , apoptosis and JNK/SAPK activity .	positive	1
1666	10200559	8772;5599	FADD;JNK	***JNK/SAPK*** activity in response to triggering of CD95 by an agonistic antibody ( alphaAPO-1 ) was also ***diminished*** by dominant-negative ***FADD*** or zVAD .	negative	0
1667	10200559	8772;5601	FADD;SAPK	***JNK/SAPK*** activity in response to triggering of CD95 by an agonistic antibody ( alphaAPO-1 ) was also ***diminished*** by dominant-negative ***FADD*** or zVAD .	negative	0
1668	10200559	8743;5599	TRAIL;JNK	Therefore , ***activation*** of ***JNK/SAPKs*** by ***TRAIL*** or alphaAPO-1 occurs downstream of FADD and caspases and contributes to apoptosis in human lymphoid cell lines .	positive	1
1669	10200578	7157;355	p53;CD95	***p53-mediated*** ***up-regulation*** of ***CD95*** is not involved in genotoxic drug-induced apoptosis of human breast tumor cells .	positive	1
1670	10201021	958;959	CD40;CD154	BACKGROUND : ******CD40-CD154****** ( CD40L ) costimulatory ***signaling*** plays a pivotal role in the effector mechanisms of transplant graft rejection .	parallel	0
1671	10201021	958;959	CD40;CD154	Given the critical importance of ******CD40-CD154****** ***interactions*** in the development of chronic transplant allograft rejection , the relevance of in situ CD40 and CD154 expression was assessed in human chronic renal allograft rejection .	parallel	1
1672	10201024	7035;2152	TFPI;tissue factor	RESULTS : Prior to hemofiltration , most patients had increased levels of plasma tissue factor , thrombin-antithrombin ( TAT ) complexes , and ***tissue factor*** pathway ***inhibitor*** ( ***TFPI*** ) ; during hemofiltration , further generation of TAT complexes occurred .	negative	1
1673	10201372	1499;595	Beta-catenin;cyclin D1	***Beta-catenin*** ***regulates*** expression of ***cyclin D1*** in colon carcinoma cells .	target	1
1674	10201372	3265;595	p21ras;cyclin D1	The oncoprotein ***p21ras*** further ***activates*** transcription of the ***cyclin D1*** gene , through sites within the promoter that bind the transcriptional regulators Ets or CREB .	positive	1
1675	10201887	7099;4790	TLR4;NF-kappaB	Overexpression of wild-type ***TLR4*** but not the mutant TLR4 from C3H/HeJ mice ***activated*** ***NF-kappaB*** .	positive	1
1676	10201892	8651;3565	SOCS-1;IL-4	Cutting edge : ***SOCS-1*** is a potent ***inhibitor*** of ***IL-4*** signal transduction .	negative	1
1677	10201892	8651;6778	SOCS-1;Stat6	We have examined the ability of SOCS family members to suppress IL-4 signaling , and we have found that ***SOCS-1*** potently ***inhibits*** the activation of JAK1 kinase and ***Stat6*** in response to IL-4 .	negative	1
1678	10201892	3565;2208	IL-4;CD23	Furthermore , SOCS-1 can inhibit the ***induction*** of ***CD23*** expression by ***IL-4*** .	target	1
1679	10201892	9021;3565	SOCS-3;IL-4	SOCS-2 does not inhibit induction of signaling by IL-4 , while ***inhibition*** of ***IL-4*** signaling by ***SOCS-3*** can be detected in transient transfection systems , but not in stable cell lines .	negative	1
1680	10201899	940;1432	CD28;p38	However , ***p38*** MAPK is ***activated*** strongly and synergistically by either ***CD3/CD28*** coligation or PMA/Ca2 + ionophore stimulation , which mimics TCR-CD3 / CD28-mediated signaling .	positive	1
1681	10201899	5594;3725	MAPK 1;c-Jun	Our findings demonstrate that p38 ***MAPK 1*** ) plays an important role in signal integration during costimulation of primary mouse T cells , 2 ) may be involved in the ***induction*** of ***c-Jun*** activation and augmentation of AP-1 transcriptional activity , and 3 ) regulates whether T cells enter a state of functional unresponsiveness .	target	1
1682	10201904	7124;5594	TNF-alpha;ERK2	***TNF-alpha*** ***induced*** tyrosine phosphorylation and enzymatic activation of ***ERK2*** , SAPK/JNK , and p38mapk , whereas IL-10 did not induce these events .	target	1
1683	10201904	7124;5599	TNF-alpha;JNK	***TNF-alpha*** ***induced*** tyrosine phosphorylation and enzymatic activation of ERK2 , ***SAPK/JNK*** , and p38mapk , whereas IL-10 did not induce these events .	target	1
1684	10201904	7124;5601	TNF-alpha;SAPK	***TNF-alpha*** ***induced*** tyrosine phosphorylation and enzymatic activation of ERK2 , ***SAPK/JNK*** , and p38mapk , whereas IL-10 did not induce these events .	target	1
1685	10201923	728;727	C5aR;C5a	In this study , we present the first evidence that human T cells express the ***C5a*** ***receptor*** ( ***C5aR*** ) and are chemotactic to C5a .	parallel	1
1686	10201924	7124;4792	TNF-alpha;I kappa B alpha	In contrast , ***TNF-alpha*** ***induced*** degradation of ***I kappa B alpha*** in the neuronal cells , suggesting that failure to induce I kappa B alpha degradation is likely due to a defect in virus-mediated signaling rather than to a defect involving neuronal I kappa B alpha .	target	1
1687	10201928	3458;6772	IFN-gamma;Stat1	***Stat1*** , which is ***activated*** by ***IFN-gamma*** , can not recognize the Stat6-specific IL-4 response element in the epsilon promoter .	positive	1
1688	10201929	3725;2353	Jun;Fos	In addition , DNA-binding activities of ******Jun-Fos****** ***heterodimers*** were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity .	parallel	1
1689	10201938	1493;940	CTLA-4;CD28	T cells require ******CD28/CTLA-4****** costimulatory molecule ***interactions*** in addition to Ag-specific signals through the TCR for in vivo effector Th cell function .	parallel	1
1690	10201939	958;959	CD40;CD40 ligand	******CD40 ligand-CD40****** ***interaction*** induces chemokines in cervical carcinoma cells in synergism with IFN-gamma .	parallel	1
1691	10201939	959;958	CD40L;CD40	In this study , we show high CD40 expression on cervical carcinoma cells and CD40 ligand ( CD40L ) staining on attracted T cells in tumor tissue , suggesting a paracrine stimulation mechanism via ******CD40L-CD40****** ***interactions*** .	parallel	1
1692	10201939	959;6347	CD40L;MCP-1	***CD40L*** was able to ***induce*** ***MCP-1*** production ; however , despite much higher CD40 expression in malignant cells , MCP-1 induction was significantly lower compared with nontumorigenic cells .	target	1
1693	10201951	7124;4790	TNF-alpha;NF-kappa B	These data suggest that in fibroblasts ***TNF-alpha*** ***activates*** and initiates the nuclear translocation of ***NF-kappa B*** that binds a divergent NF-kappa B element and plays a critical role in the observed inhibition of alpha 2(I) collagen gene transcription .	positive	1
1694	10201953	566;7124	HBP;TNF-alpha	In the current study , we hypothesize that HBP is internalized in monocytes via endocytosis , and this internalization is an important mechanism by which ***HBP*** ***enhances*** LPS-induced ***TNF-alpha*** release .	positive	0
1695	10201954	3553;1432	IL-1beta;p38alpha	***IL-1beta*** ***activated*** ***p38alpha*** and p38beta in endothelial cells .	positive	1
1696	10201954	3553;5600	IL-1beta;p38beta	***IL-1beta*** ***activated*** p38alpha and ***p38beta*** in endothelial cells .	positive	1
1697	10201956	3553;3569	IL-1;IL-6	We have recently reported that LPS augments IL-1RI mRNA expression in the hepatocytes of mice in vivo , and the augmentation is mediated by the ***interaction*** of ***IL-1*** , ***IL-6*** , and glucocorticoid ( GC ) .	parallel	1
1698	10201958	4803;27306	NGF;PGD2	More recently , ***NGF*** has been demonstrated to ***induce*** ***PGD2*** production by mast cells through the induction of mast cell cyclooxygenase expression .	target	1
1699	10201958	4803;7124	NGF;TNF-alpha	We have observed that ***NGF*** at doses as low as 10 ng/ml will induce IL-6 production and ***inhibit*** ***TNF-alpha*** release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor .	negative	1
1700	10201960	3558;1232	IL-2;CCR3	We have observed a novel phenomenon that ***IL-2*** and IL-4 ***induce*** the expression of ***CCR3*** on T lymphocytes .	target	1
1701	10201960	3565;1232	IL-4;CCR3	We have observed a novel phenomenon that IL-2 and ***IL-4*** ***induce*** the expression of ***CCR3*** on T lymphocytes .	target	1
1702	10201961	3603;920	IL-16;CD4 molecule	In the synovial tissue , CD8 + T cells were the major source of ***IL-16*** , a natural ***ligand*** of the ***CD4 molecule*** that can anergize CD4-expressing cells .	parallel	1
1703	10201972	3458;6772	IFN-gamma;STAT1	Here , we observed that class II MHC trans-activator and ***STAT1*** alpha mRNA , mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction , were markedly ***increased*** by ***IFN-gamma*** stimulation in phorbol ester-activated THP-1 cells ; however , both mRNAs were not increased by phorbol ester treatment alone .	positive	0
1704	10201980	6714;695	Src;Btk	Although ***Btk*** activity can be ***regulated*** by ***Src-family*** and Syk tyrosine kinases , and perhaps by phosphatidylinositol 3,4,5-trisphosphate , BCR-coupled signaling pathways leading to Btk activation are poorly understood .	target	1
1705	10201980	930;695	CD19;Btk	Taken together , the data presented indicate that BCR aggregation-driven ***CD19*** phosphorylation functions to ***promote*** ***Btk*** activation via recruitment and activation of PI3-K .	positive	0
1706	10201981	7124;3576	TNF-alpha;IL-8	***Induction*** of ***IL-8*** gene expression by ***TNF-alpha*** was partially inhibited in Ad5dnTRAF-2-transfected HT-29 , but not in control Ad5LacZ-infected , cells .	target	1
1707	10201989	3600;3458	IL-15;IFN-gamma	***IL-15*** and IL-12 ***induced*** less ***IFN-gamma*** protein ( 24 + / - 10 ng/ml ; p < 0.007 ) and only a 45 + / - 19-fold increase in IFN-gamma gene expression over those in resting NK cells .	target	1
1708	10201989	3600;1437	IL-15;CSF	Granulocyte-macrophage ***CSF*** was optimally ***induced*** by ***IL-15*** and IL-18 .	target	1
1709	10201989	3606;1437	IL-18;CSF	Granulocyte-macrophage ***CSF*** was optimally ***induced*** by IL-15 and ***IL-18*** .	target	1
1710	10201993	3479;596	IGF-I;Bcl-2	We next established that IL-3 , IL-4 , and ***IGF-I*** ***increase*** expression of ***Bcl-2*** by > 3-fold .	positive	0
1711	10201993	3562;596	IL-3;Bcl-2	We next established that ***IL-3*** , IL-4 , and IGF-I ***increase*** expression of ***Bcl-2*** by > 3-fold .	positive	0
1712	10201993	3565;596	IL-4;Bcl-2	We next established that IL-3 , ***IL-4*** , and IGF-I ***increase*** expression of ***Bcl-2*** by > 3-fold .	positive	0
1713	10201998	3458;5743	IFN-gamma;COX-2	***IFN-gamma*** ***up-regulated*** expression and activity of ***COX-2*** in medullary cells , in which COX-2 was expressed constitutively .	positive	1
1714	10202009	7433;7432	VPAC1;VIP	***VPAC1*** , the type 1 VIP receptor , which is constitutively expressed in macrophages , and to a lesser degree VPAC2 , the type 2 ***VIP*** ***receptor*** , which is induced upon macrophage activation , mediate the effect of VIP/PACAP .	parallel	1
1715	10202009	7433;116	VPAC1;PACAP	***VPAC1*** , the type 1 VIP receptor , which is constitutively expressed in macrophages , and to a lesser degree VPAC2 , the type 2 VIP receptor , which is induced upon macrophage activation , ***mediate*** the effect of ***VIP/PACAP*** .	target	0
1716	10202009	7433;7432	VPAC1;VIP	***VPAC1*** , the type 1 VIP receptor , which is constitutively expressed in macrophages , and to a lesser degree VPAC2 , the type 2 VIP receptor , which is induced upon macrophage activation , ***mediate*** the effect of ***VIP/PACAP*** .	target	0
1717	10202009	7434;116	VPAC2;PACAP	VPAC1 , the type 1 VIP receptor , which is constitutively expressed in macrophages , and to a lesser degree ***VPAC2*** , the type 2 VIP receptor , which is induced upon macrophage activation , ***mediate*** the effect of ***VIP/PACAP*** .	target	0
1718	10202009	7434;7432	VPAC2;VIP	VPAC1 , the type 1 VIP receptor , which is constitutively expressed in macrophages , and to a lesser degree ***VPAC2*** , the type 2 VIP receptor , which is induced upon macrophage activation , ***mediate*** the effect of ***VIP/PACAP*** .	target	0
1719	10202009	116;4843	PACAP;iNOS	***VIP/PACAP*** ***inhibit*** ***iNOS*** expression and activity both in vivo and in vitro .	negative	1
1720	10202009	7432;4843	VIP;iNOS	***VIP/PACAP*** ***inhibit*** ***iNOS*** expression and activity both in vivo and in vitro .	negative	1
1721	10202009	4790;4843	NF-kappa B;iNOS	Two transduction pathways appear to be involved , a cAMP-dependent pathway that preferentially inhibits IFN regulatory factor-1 transactivation and a cAMP-independent pathway that blocks ***NF-kappa B*** ***binding*** to the ***iNOS*** promoter .	parallel	1
1722	10202014	3458;4261	IFN-gamma;CIITA	Functionally , the proximal IRF element is essential for ***IFN-gamma*** ***induction*** of type IV ***CIITA*** promoter activity , while the proximal GAS and E box elements contribute to the IFN-gamma inducibility of this promoter .	target	1
1723	10202014	3458;4261	IFN-gamma;CIITA	Our results demonstrate that TNF-alpha does not enhance ***IFN-gamma-induced*** transcriptional ***activation*** of the type IV ***CIITA*** promoter , indicating that the enhancing effect of TNF-alpha is mediated downstream of CIITA transcription .	positive	1
1724	10202026	6346;6348	TCA3;MIP-1alpha	Of the two lymphocyte-attracting chemokines assessed , monocyte-chemotactic protein-1 and macrophage-inflammatory protein-1alpha ( MIP-1alpha ) , only MIP-1alpha was reduced when TCA3 was neutralized , indicating that ***TCA3*** ***affects*** the levels of ***MIP-1alpha*** , which attracts lymphocytes into the sponges .	target	0
1725	10202031	3562;5141	IL-3;PDE4	***IL-3*** and IL-4 ***activate*** cyclic nucleotide phosphodiesterases 3 ( PDE3 ) and 4 ( ***PDE4*** ) by different mechanisms in FDCP2 myeloid cells .	positive	1
1726	10202031	3565;5141	IL-4;PDE4	IL-3 and ***IL-4*** ***activate*** cyclic nucleotide phosphodiesterases 3 ( PDE3 ) and 4 ( ***PDE4*** ) by different mechanisms in FDCP2 myeloid cells .	positive	1
1727	10202031	1437;5141	CSF;PDE4	In FDCP2 myeloid cells , IL-4 activated cyclic nucleotide phosphodiesterases PDE3 and PDE4 , whereas IL-3 , granulocyte-macrophage ***CSF*** ( GM-CSF ) , and phorbol ester ( PMA ) selectively ***activated*** ***PDE4*** .	positive	1
1728	10202031	3562;5141	IL-3;PDE4	In FDCP2 myeloid cells , IL-4 activated cyclic nucleotide phosphodiesterases PDE3 and PDE4 , whereas ***IL-3*** , granulocyte-macrophage CSF ( GM-CSF ) , and phorbol ester ( PMA ) selectively ***activated*** ***PDE4*** .	positive	1
1729	10202031	3565;5141	IL-4;PDE4	In FDCP2 myeloid cells , ***IL-4*** ***activated*** cyclic nucleotide phosphodiesterases PDE3 and ***PDE4*** , whereas IL-3 , granulocyte-macrophage CSF ( GM-CSF ) , and phorbol ester ( PMA ) selectively activated PDE4 .	positive	1
1730	10202031	3565;8660	IL-4;insulin-receptor substrate-2	***IL-4*** ( not IL-3 or GM-CSF ) ***induced*** tyrosine phosphorylation of ***insulin-receptor substrate-2*** ( IRS-2 ) and its association with phosphatidylinositol 3-kinase ( PI3-K ) .	target	1
1731	10202031	7124;5141	TNF-alpha;PDE4	***TNF-alpha*** , AG-490 ( Janus kinase inhibitor ) , and wortmannin ( PI3-K inhibitor ) ***inhibited*** activation of PDE3 and ***PDE4*** by IL-4 .	negative	1
1732	10202031	3565;5141	IL-4;PDE4	TNF-alpha , AG-490 ( Janus kinase inhibitor ) , and wortmannin ( PI3-K inhibitor ) inhibited ***activation*** of PDE3 and ***PDE4*** by ***IL-4*** .	positive	1
1733	10202031	3565;8660	IL-4;IRS-2	TNF-alpha also blocked ***IL-4-induced*** tyrosine ***phosphorylation*** of ***IRS-2*** , but not of STAT6 .	target	1
1734	10202031	7124;8660	TNF-alpha;IRS-2	***TNF-alpha*** also ***blocked*** IL-4-induced tyrosine phosphorylation of ***IRS-2*** , but not of STAT6 .	negative	0
1735	10202031	3562;5141	IL-3;PDE4	AG-490 and wortmannin , not TNF-alpha , inhibited ***activation*** of ***PDE4*** by ***IL-3*** .	positive	1
1736	10202031	3565;5141	IL-4;PDE4	These results suggested that ***IL-4-induced*** ***activation*** of PDE3 and ***PDE4*** was downstream of IRS-2/PI3-K , not STAT6 , and that inhibition of tyrosine phosphorylation of IRS molecules might be one mechnism whereby TNF-alpha could selectively regulate activities of cytokines that utilized IRS proteins as signal transducers .	positive	1
1737	10202034	5594;4790	ERK1/2;NF-kappa B	We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ***ERK1/2*** and JNK pathway-dependent ***activation*** of ***NF-kappa B*** transcriptional capacity .	positive	1
1738	10202034	5599;4790	JNK;NF-kappa B	We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and ***JNK*** pathway-dependent ***activation*** of ***NF-kappa B*** transcriptional capacity .	positive	1
1739	10202035	1803;6356	CD26;eotaxin	***CD26/dipeptidyl-peptidase IV*** ***down-regulates*** the eosinophil chemotactic potency , but not the anti-HIV activity of human ***eotaxin*** by affecting its interaction with CC chemokine receptor 3 .	negative	1
1740	10202035	1803;6356	CD26;eotaxin	In this study we demonstrate that ***eotaxin*** is efficiently ***cleaved*** by ***CD26/DPP IV*** and that the NH2-terminal truncation affects its biological activity .	target	1
1741	10202038	3552;1958	IL-1alpha;Egr-1	***IL-1alpha*** also ***induced*** ***Egr-1*** expression in these cells .	target	1
1742	10202038	3552;960	IL-1alpha;CD44	These studies therefore identify Egr-1 as a critical transcription factor involved in ***CD44*** ***induction*** by ***IL-1alpha*** .	target	1
1743	10202039	3565;3627	IL-4;IP-10	Furthermore , IL-10 and ***IL-4*** significantly ***suppressed*** the expression of MIG , ***IP-10*** , and I-TAC mRNA and the extracellular production of MIG and IP-10 in neutrophils stimulated with IFN-gamma plus either LPS or TNF-alpha .	negative	1
1744	10202039	3565;6373	IL-4;I-TAC	Furthermore , IL-10 and ***IL-4*** significantly ***suppressed*** the expression of MIG , IP-10 , and ***I-TAC*** mRNA and the extracellular production of MIG and IP-10 in neutrophils stimulated with IFN-gamma plus either LPS or TNF-alpha .	negative	1
1745	10202049	8744;941	4-1BBL;B7-1	***4-1BBL*** ***cooperates*** with ***B7-1*** and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine .	parallel	0
1746	10202049	8744;942	4-1BBL;B7-2	***4-1BBL*** ***cooperates*** with B7-1 and ***B7-2*** in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine .	parallel	0
1747	10202109	4267;3559	CD99;CD25	***CD99*** coligation also ***enhanced*** ***CD25*** expression and early markers of T cell activation , CD69 and CD40L .	positive	0
1748	10202109	4267;959	CD99;CD40L	***CD99*** coligation also ***enhanced*** CD25 expression and early markers of T cell activation , CD69 and ***CD40L*** .	positive	0
1749	10202109	4267;969	CD99;CD69	***CD99*** coligation also ***enhanced*** CD25 expression and early markers of T cell activation , ***CD69*** and CD40L .	positive	0
1750	10202109	914;959	CD2;CD40L	Simultaneous costimulation with anti-CD99 and anti-CD28 Abs appeared to have additive effects on CD40L expression while CD99 ligation had no effect on ***CD2-mediated*** T cell ***induction*** of ***CD40L*** expression .	target	1
1751	10202144	7157;4193	p53;Mdm2	This is consistent with the conclusion that phosphorylation of Ser20 in vivo attenuates the ***binding*** of wild-type ***p53*** to ***Mdm2*** .	parallel	1
1752	10202144	4193;7157	Mdm2;p53	This implies a critical role for Ser20 in modulating the negative ***regulation*** of ***p53*** by ***Mdm2*** , probably through phosphorylation-dependent inhibition of p53-Mdm2 interaction .	negative	1
1753	10202144	7157;4193	p53;Mdm2	This implies a critical role for Ser20 in modulating the negative regulation of p53 by Mdm2 , probably through phosphorylation-dependent inhibition of ******p53-Mdm2****** ***interaction*** .	parallel	1
1754	10202144	4193;7157	Mdm2;p53	Critical role for Ser20 of human p53 in the negative ***regulation*** of ***p53*** by ***Mdm2*** .	negative	1
1755	10202144	7157;4193	p53;Mdm2	While the in vitro ***binding*** of ***p53*** to ***Mdm2*** is not increased by the Ala20 mutation , the same mutation results in a markedly enhanced binding in vivo .	parallel	1
1756	10202150	245711;1017	Spy1;cdk2	In addition , we have shown that ***Spy1*** physically ***interacts*** with ***cdk2*** , and prematurely activates cdk2 kinase activity .	parallel	1
1757	10202150	245711;1017	Spy1;cdk2	In addition , we have shown that ***Spy1*** physically interacts with cdk2 , and prematurely ***activates*** ***cdk2*** kinase activity .	positive	1
1758	10202156	6839;10951	SUV39H1;M31	In addition , ***SUV39H1/SUV39H1*** proteins ***associate*** with ***M31*** , currently the only other characterized mammalian SU ( VAR ) homologue .	parallel	0
1759	10202161	9972;7214	nucleoporin Nup153;TRN1	We employed a phage display system to search for proteins that interact with transportin 1 ( TRN1 ) , the import receptor for shuttling hnRNP proteins with an M9 nuclear localization sequence ( NLS ) , and identified a short region within the N-terminus of the ***nucleoporin Nup153*** which ***binds*** ***TRN1*** .	parallel	1
1760	10202163	7518;3981	Xrcc4;DNA ligase IV	***Xrcc4*** also ***binds*** to ***DNA ligase IV*** and enhances its joining activity .	parallel	1
1761	10202187	4233;3082	c-Met;hepatocyte growth factor	Expression of ***hepatocyte growth factor/scatter factor*** and its ***receptor*** ***c-Met*** in brain tumors : evidence for a role in progression of astrocytic tumors ( Review ) .	parallel	1
1762	10202558	940;1493	CD28;CTLA-4	Manipulation of ******CD28/CTLA-4****** ***interactions*** with their natural ligands has provided exciting results in transplantation and tumor therapy settings and also has potential in the treatment of several diseases such as arthritis and multiple sclerosis , asthma and protection against HIV infection .	parallel	1
1763	10203183	7018;3569	transferrin;IL-6	However , the experiments show that despite the absence of a macroscopic effect , Sertoli cells respond to ionizing radiation by increasing transferrin secretion , ***transferrin*** ***response*** to ( Bu ) 2cAMP stimulation and ***IL-6*** activity .	parallel	0
1764	10203248	3458;3162	interferon-gamma;heme oxygenase-1	In rat glial cells , lipopolysaccharide and ***interferon-gamma*** ( LPS/IFN-gamma ) ***induced*** expression of both inducible nitric oxide synthase ( iNOS ) and ***heme oxygenase-1*** ( HO-1 ) .	target	1
1765	10203248	5468;3162	PPARgamma;HO-1	These results suggest that activation of ***PPARgamma*** negatively regulate iNOS expression and positively ***regulates*** ***HO-1*** expression in glial cells .	positive	1
1766	10203281	3486;3481	IGFBP-3;IGF-II	RESULTS : ***IGFBP-3*** levels ***correlated*** with IGF-I levels ( r = .64 ) and with ***IGF-II*** levels ( r = .90 ) .	parallel	0
1767	10203355	5970;4790	p65;p50	PDTC and Dex completely inhibited the ******p65/p50****** ***heterodimer*** , but HerA and AG490 had little effect on p65/p50 .	parallel	1
1768	10203355	3717;4843	JAK2;iNOS	AG490 and ***JAK2*** antisense oligonucleotides ***suppressed*** ***iNOS*** promoter activity .	negative	1
1769	10203356	7040;7422	TGF-beta1;vascular endothelial growth factor	***vascular endothelial growth factor*** ( VEGF ) , a potent promoter of vascular permeability , is ***induced*** in mesangial cells by both mechanical stretch and ***TGF-beta1*** .	target	1
1770	10203363	7040;4313	TGF-beta;MMP-2	***TGF-beta*** completely blocked the conversion of plasminogen to plasmin and markedly ***reduced*** the conversion of latent ***MMP-2*** to active MMP-2 .	negative	1
1771	10203364	5744;3569	PTHrP;IL-6	These results indicate that C-terminal ***PTHrP*** , like its N-terminal domain , ***induces*** ***IL-6*** production by human osteoblastic cells .	target	1
1772	10203364	5741;3569	PTH;interleukin-6	***PTH*** ( 1-34 ) and PTHrP ( 1-34 ) rapidly ***induce*** ***interleukin-6*** ( IL-6 ) expression by osteoblasts .	target	1
1773	10203364	5744;3569	PTHrP;interleukin-6	PTH ( 1-34 ) and ***PTHrP*** ( 1-34 ) rapidly ***induce*** ***interleukin-6*** ( IL-6 ) expression by osteoblasts .	target	1
1774	10203579	596;836	Bcl-2;caspase 3	Retrovirally introduced ***Bcl-2*** ***prevented*** beta-Lap-mediated ***caspase 3*** activation and PARP cleavage and increased the viability of Bcl-2-expressing HL-60 cells compared to cells with vector alone .	negative	0
1775	10203579	596;142	Bcl-2;PARP	Retrovirally introduced ***Bcl-2*** ***prevented*** beta-Lap-mediated caspase 3 activation and ***PARP*** cleavage and increased the viability of Bcl-2-expressing HL-60 cells compared to cells with vector alone .	negative	0
1776	10203687	356;355	CD95-L;CD95	Upon treatment ***CD95*** ***ligand*** ( ***CD95-L*** ) was induced that stimulated the CD95 pathway by crosslinking CD95 via an autocrine/paracrine loop .	parallel	1
1777	10203695	596;836	bcl-2;caspase 8 and 3	Here , we report that ***caspase 8 and 3*** activation , poly ( ADP-ribose ) polymerase cleavage and apoptosis are ***inhibited*** by the lipoxygenase inhibitor , nordihydroguaretic acid ( NDGA ) , or ectopic expression of crm-A or ***bcl-2*** .	negative	1
1778	10203808	4609;7015	MYC;TERT	Recent evidence has shown that ***MYC*** ***upregulates*** the catalytic subunit of telomerase , ***TERT*** , and that TERT cooperates with HPV E7 in cell immortalization .	positive	1
1779	10204571	3458;3455	IFN-gamma;interferon receptor	Interferon gamma ( ***IFN-gamma*** ) ***stimulates*** the ( pro-inflammatory ) type II ***interferon receptor*** and is known to exacerbate multiple sclerosis ( MS ) .	positive	0
1780	10204571	3439;3455	IFN-alpha;interferon receptor	In contrast , ***IFN-alpha*** and IFN-beta are ***ligands*** for the ( anti-inflammatory ) type I ***interferon receptor*** and are beneficial in some ( but not all ) patients with MS.	parallel	1
1781	10204571	3456;3455	IFN-beta;interferon receptor	In contrast , IFN-alpha and ***IFN-beta*** are ***ligands*** for the ( anti-inflammatory ) type I ***interferon receptor*** and are beneficial in some ( but not all ) patients with MS.	parallel	1
1782	10204582	6464;2885	Shc;Grb2	***Shc*** was also inducibly tyrosine phosphorylated and ***bound*** to ***Grb2*** after Fc gammaRI stimulation of the macrophages .	parallel	1
1783	10204582	5464;867	PP1;Cbl	***PP1*** , a specific inhibitor of Src kinases , ***inhibited*** the Fc gammaRI-induced respiratory burst , as well as the tyrosine phosphorylation of ***Cbl*** and its inducible association with CrkL .	negative	1
1784	10204582	867;1399	Cbl;CrkL	These results suggest a fundamental role for the tyrosine phosphorylation of Cbl , CrkL , SLP-76 , and Shc and the ***association*** of ***Cbl*** with ***CrkL*** , SLP-76 , and Nck in Fc gammaRI signaling in human macrophages .	parallel	0
1785	10204582	867;4690	Cbl;Nck	These results suggest a fundamental role for the tyrosine phosphorylation of Cbl , CrkL , SLP-76 , and Shc and the ***association*** of ***Cbl*** with CrkL , SLP-76 , and ***Nck*** in Fc gammaRI signaling in human macrophages .	parallel	0
1786	10204582	867;3937	Cbl;SLP-76	These results suggest a fundamental role for the tyrosine phosphorylation of Cbl , CrkL , SLP-76 , and Shc and the ***association*** of ***Cbl*** with CrkL , ***SLP-76*** , and Nck in Fc gammaRI signaling in human macrophages .	parallel	0
1787	10204582	867;1399	Cbl;CrkL	Experiments performed with PP1 , the specific Src kinase inhibitor , demonstrate the first evidence that Cbl and the ******Cbl-CrkL****** ***interaction*** are downstream targets for myeloid Src kinases required for the activation of myeloid NADPH oxidase activity .	parallel	1
1788	10204582	1399;867	CrkL;Cbl	***CrkL*** ***associated*** with tyrosine-phosphorylated ***Cbl*** and itself became tyrosine phosphorylated after Fc gammaRI cross-linking .	parallel	0
1789	10204582	3937;867	SLP-76;Cbl	***SLP-76*** , a recently cloned Grb2-associated protein , was strongly tyrosine phosphorylated after Fc gammaRI stimulation and was ***associated*** with both ***Cbl*** and Grb2 .	parallel	0
1790	10204582	3937;2885	SLP-76;Grb2	***SLP-76*** , a recently cloned Grb2-associated protein , was strongly tyrosine phosphorylated after Fc gammaRI stimulation and was ***associated*** with both Cbl and ***Grb2*** .	parallel	0
1791	10204802	5743;4316	Cox-2;matrilysin	To determine if there is a direct ***link*** between ***matrilysin*** and ***Cox-2*** , their expression was characterized in two mouse models of intestinal carcinogenesis and in human colorectal tumor samples .	parallel	0
1792	10204996	7201;7200	TRH-R;TRH	C335Stop is a constitutively active mutant of the ***TRH*** ***receptor*** ( ***TRH-R*** ) .	parallel	1
1793	10205054	4086;6774	Smad1;STAT3	Synergistic signaling in fetal brain by ******STAT3-Smad1****** ***complex*** bridged by p300 .	parallel	1
1794	10205054	2033;6774	p300;STAT3	The transcriptional coactivator ***p300*** ***interacts*** physically with ***STAT3*** at its amino terminus in a cytokine stimulation-independent manner , and with Smad1 at its carboxyl terminus in a cytokine stimulation-dependent manner .	parallel	1
1795	10205054	4086;6774	Smad1;STAT3	The ***formation*** of a complex between ***STAT3*** and ***Smad1*** , bridged by p300 , is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors .	parallel	0
1796	10205060	3308;3184	hsp70;AUF1	Induction of hsp70 by heat shock , down-regulation of the ubiquitin-proteasome network , or inactivation of ubiquitinating enzyme E1 all result in ***hsp70*** ***sequestration*** of ***AUF1*** in the perinucleus-nucleus , and all three processes block decay of AU-rich mRNAs and AUF1 protein .	negative	0
1797	10205143	3479;5972	insulin-like growth factor-1;renin	Overexpression of ***insulin-like growth factor-1*** ***attenuates*** the myocyte ***renin-angiotensin*** system in transgenic mice .	negative	0
1798	10205143	7157;5972	p53;renin	Moreover , activation of ***p53*** ***upregulates*** the cellular ***renin-angiotensin*** system ( RAS ) .	positive	1
1799	10205143	7157;4193	p53;Mdm2	The presence of ******Mdm2-p53****** ***complexes*** was also established .	parallel	1
1800	10205143	4193;7157	Mdm2;p53	Upregulation of IGF-1 in myocytes was associated with a protein-to-protein ***interaction*** between ***Mdm2*** and ***p53*** , which attenuated p53 transcriptional activity for bax , Aogen , and AT1 receptor .	parallel	1
1801	10205150	993;4609	cdc25A;c-myc	We conclude that ***cdc25A*** expression ***modulates*** the ability of ***c-myc*** to induce apoptosis in G1 .	target	0
1802	10205150	4609;993	c-myc;cdc25A	Therefore , the recent identification that ***cdc25A*** , a cell-cycle phosphatase involved in G1 progression , is transcriptionally ***activated*** by ***c-myc*** and regulates c-myc-induced apoptosis has suggested that cdc25A may be the principal mediator of c-myc in VSMCs .	positive	1
1803	10205150	4609;993	c-myc;cdc25A	Ectopic ***c-myc*** ***increased*** ***cdc25A*** expression , but cdc25A was still responsive to serum components , which indicated that c-myc alone is not the main determinant of cdc25A expression .	positive	0
1804	10205150	993;4609	cdc25A;c-myc	Ectopic ***cdc25A*** ***augmented*** the proproliferative and proapoptotic action of ***c-myc*** but did not increase cell proliferation or apoptosis in the absence of ectopic c-myc .	positive	0
1805	10205158	3336;3329	Hsp10;Hsp60	Presence of a pre-apoptotic ***complex*** of pro-caspase-3 , ***Hsp60*** and ***Hsp10*** in the mitochondrial fraction of jurkat cells .	parallel	1
1806	10205159	839;836	caspase-6;caspase-3	We demonstrate that the activation of ***caspase-3*** , in Jurkat cells stimulated to undergo apoptosis by a Fas-independent pathway , is ***catalyzed*** by ***caspase-6*** .	positive	1
1807	10205159	3329;836	Hsp60;caspase-3	Furthermore , an ***interaction*** between ***Hsp60*** and ***caspase-3*** could be demonstrated by co-immunoprecipitation experiments using HeLa as well as Jurkat cell extracts .	parallel	1
1808	10205165	1021;1029	cdk6;p16	The ***cdk6*** protein is found to ***suppress*** ***p16*** ( INK4a ) - mediated inhibition of spreading and is also shown to localize to the ruffling edge of spreading cells , indicating a function for cdk6 in controlling matrix-dependent cell spreading .	negative	1
1809	10205199	7032;7033	hTFF2;TFF3	In addition , endogenous concentrations of rat TFF2 and ***TFF3*** ( intestinal trefoil factor ) were increased in the active phase of colitis and were ***reduced*** to basal levels by ***hTFF2*** treatment .	negative	1
1810	10205202	3458;4843	IFN-gamma;iNOS	AIMS : To examine ***iNOS*** ***induction*** by ***IFN-gamma*** in vitro as a function of enterocyte differentiation .	target	1
1811	10205202	3458;4843	IFN-gamma;iNOS	RESULTS : ***iNOS*** mRNA ***induction*** by ***IFN-gamma*** occurred at two hours and was not blocked by cycloheximide , indicating that it is an immediate early response .	target	1
1812	10205242	56681;183	Sar1;angiotensin II	Specific [ 125I ] ******Sar1-angiotensin II****** ***binding*** was detected by receptor autoradiography .	parallel	1
1813	10205242	56681;183	Sar1;angiotensin II	The ***binding*** of [ 125I ] ******Sar1-angiotensin II****** was completely displaced by the AT1 antagonist losartan but not by the AT2 receptor ligand PD 123319 , confirming the expression of angiotensin II AT1 receptors in NCI-H295 cells .	parallel	1
1814	10205255	4683;4361	nbs1;Mre11	The mammalian ******Mre11-Rad50-nbs1****** protein ***complex*** : integration of functions in the cellular DNA-damage response .	parallel	1
1815	10205255	10111;4361	Rad50;Mre11	The mammalian ******Mre11-Rad50-nbs1****** protein ***complex*** : integration of functions in the cellular DNA-damage response .	parallel	1
1816	10205255	10111;4683	Rad50;nbs1	The mammalian ******Mre11-Rad50-nbs1****** protein ***complex*** : integration of functions in the cellular DNA-damage response .	parallel	1
1817	10205288	183;2353	angiotensin II;c-Fos	The data demonstrate that lovastatin can suppress PDGF - and ***angiotensin II-mediated*** ***induction*** of c-Jun and ***c-Fos*** protein in human SMC .	target	1
1818	10205288	183;3725	angiotensin II;c-Jun	The data demonstrate that lovastatin can suppress PDGF - and ***angiotensin II-mediated*** ***induction*** of ***c-Jun*** and c-Fos protein in human SMC .	target	1
1819	10205665	5925;1029	pRb;p16	INK4a , CDKN2 , or MTS1 , plays an important role in the control of the cell cycle progression , and retinoblastoma protein ( ***pRb*** ) is suggested to be involved in the transcriptional ***regulation*** of ***p16*** .	target	1
1820	10205665	5925;1029	pRb;p16	However , it is not fully understood how ***pRb*** ***regulates*** transcription of the ***p16*** gene .	target	1
1821	10205679	2230;2232	adrenodoxin;adrenodoxin reductase	The ***formation*** of individual complexes between the components of cholesterol side chain cleavage system-cytochrome P450scc , ***adrenodoxin*** ( Ad ) and ***adrenodoxin reductase*** ( AdR ) was kinetically characterized and their association and dissociation rate constants were measured by optical biosensor .	parallel	0
1822	10205679	2230;1583	adrenodoxin;P450scc	The ***formation*** of individual complexes between the components of cholesterol side chain cleavage system-cytochrome ***P450scc*** , ***adrenodoxin*** ( Ad ) and adrenodoxin reductase ( AdR ) was kinetically characterized and their association and dissociation rate constants were measured by optical biosensor .	parallel	0
1823	10205679	1583;2232	P450scc;adrenodoxin reductase	The ***formation*** of individual complexes between the components of cholesterol side chain cleavage system-cytochrome ***P450scc*** , adrenodoxin ( Ad ) and ***adrenodoxin reductase*** ( AdR ) was kinetically characterized and their association and dissociation rate constants were measured by optical biosensor .	parallel	0
1824	10206145	3553;3620	IL-1;IDO	This ***IL-1-mediated*** ***inhibition*** of IFN-gamma-induced ***IDO*** activity and toxoplasmostasis could be blocked by monomethyl L-arginine , an inhibitor of NO production .	negative	1
1825	10206147	3565;3458	IL-4;IFN-gamma	In addition , ***IL-4*** ***antagonized*** in part the bactericidal effect of TNF-alpha and ***IFN-gamma*** .	negative	1
1826	10206147	3565;7124	IL-4;TNF-alpha	In addition , ***IL-4*** ***antagonized*** in part the bactericidal effect of ***TNF-alpha*** and IFN-gamma .	negative	1
1827	10206151	983;9133	cdc2;cyclin B2	The Xenopus prophase-blocked oocyte contains a stockpile of ******cyclin B2-cdc2****** ***complexes*** that are maintained inactive by a double inhibitory phosphorylation on Thr-14 and Tyr-15 of cdc2 .	parallel	1
1828	10206185	1906;7412	Endothelin-1;vascular cell adhesion molecule-1	***Endothelin-1*** ***enhances*** ***vascular cell adhesion molecule-1*** expression in tumor necrosis factor alpha-stimulated vascular endothelial cells .	positive	0
1829	10206185	1906;7412	Endothelin-1;VCAM-1	***Endothelin-1*** ***enhanced*** the surface expression and mRNA accumulation of ***VCAM-1*** in cells treated with tumor necrosis factor alpha ( TNF-alpha ) .	positive	0
1830	10206233	7436;348	VLDL-R;apoE	The 5-repeat allele of a CGG repeat polymorphism in the 5 ' untranslated region of the very low-density lipoprotein receptor ( ***VLDL-R*** ) gene , a ***receptor*** for ***apoE*** , has been found to be associated with increased risk of AD in a Japanese population .	parallel	1
1831	10206287	5054;5328	PAI-1;uPA	Prognostic significance of urokinase ( ***uPA*** ) and its ***inhibitor*** ***PAI-1*** for survival in advanced ovarian carcinoma stage FIGO IIIc .	negative	1
1832	10206287	5054;5328	PAI-1;uPA	We evaluated the prognostic impact of the protease urokinase plasminogen activator ( ***uPA*** ) and its ***inhibitor*** ***PAI-1*** on overall survival in patients with advanced ovarian cancer stage FIGO IIIc in order to select patients at risk .	negative	1
1833	10206332	4233;3082	c-Met;HGF	Generally , mesenchymal cells such as fibroblasts produce HGF/SF but do not express ***c-Met*** , a ***receptor*** for ***HGF/SF*** , yet fibroblasts in dental papilla and cultured fibroblasts prepared from dental papilla did express c-Met , as determined by immunohistochemistry , in situ hybridization and reverse transcription-polymerase chain reaction .	parallel	1
1834	10206347	7040;2353	TGF-beta1;c-fos	In addition , by transient transfection analysis , ***TGF-beta1*** was shown to ***stimulate*** ***c-fos*** serum response element ( SRE ) - driven reporter gene activity in a dose - and time-dependent manner , suggesting that SRE is one of the nuclear targets of TGF-beta1 .	positive	0
1835	10206577	3565;3815	interleukin 4;c-kit	***interleukin 4*** up-regulates mast cell ICAM-1 and cell-bound IgE , but ***down-regulates*** ***c-kit*** .	negative	1
1836	10206577	3565;3383	interleukin 4;ICAM-1	***interleukin 4*** ***up-regulates*** mast cell ***ICAM-1*** and cell-bound IgE , but down-regulates c-kit .	positive	1
1837	10206955	945;5777	CD33;SHP-1	The myeloid-specific sialic acid-binding receptor , ***CD33*** , ***associates*** with the protein-tyrosine phosphatases , ***SHP-1*** and SHP-2 .	parallel	0
1838	10206955	945;5781	CD33;SHP-2	The myeloid-specific sialic acid-binding receptor , ***CD33*** , ***associates*** with the protein-tyrosine phosphatases , SHP-1 and ***SHP-2*** .	parallel	0
1839	10206955	945;5777	CD33;SHP-1	Phosphorylated ***CD33*** ***recruited*** both the protein-tyrosine phosphatases , ***SHP-1*** and SHP-2 .	target	0
1840	10206955	945;5781	CD33;SHP-2	Phosphorylated ***CD33*** ***recruited*** both the protein-tyrosine phosphatases , SHP-1 and ***SHP-2*** .	target	0
1841	10206959	7157;4312	p53;matrix metalloproteinase-1	***p53*** ***down-regulates*** human ***matrix metalloproteinase-1*** ( Collagenase-1 ) gene expression .	negative	1
1842	10206963	336;4018	apoA-II;lipoprotein	In conclusion , overexpression of human ***apoA-II*** in transgenic mice ***induced*** the proatherogenic ***lipoprotein*** profile of low plasma HDL and postprandial hypertriglyceridemia because of decreased VLDL catabolism by LPL .	target	1
1843	10206970	4018;4790	lipoprotein;NF-kappaB	Extensively oxidized low density ***lipoprotein*** ( ox-LDL ) , a modulator of atherogenesis , ***down-regulates*** the lipopolysaccharide ( LPS ) - induced activation of transcription factor ***NF-kappaB*** .	negative	1
1844	10206976	1978;1977	4E-BP1;eIF4E	In the present study , leucine stimulated phosphorylation of the eIF4E-binding protein , 4E-BP1 , in L6 myoblasts , resulting in dissociation of eIF4E from the inactive ******eIF4E.4E-BP1****** ***complex*** .	parallel	1
1845	10206993	3576;3577	IL-8;CXCR1	This study demonstrates that ***IL-8*** ***recognizes*** and activates ***CXCR1*** , CXCR2 , and the Duffy antigen by distinct mechanisms .	target	1
1846	10206993	3576;3579	IL-8;CXCR2	This study demonstrates that ***IL-8*** ***recognizes*** and activates CXCR1 , ***CXCR2*** , and the Duffy antigen by distinct mechanisms .	target	1
1847	10206997	5141;6714	pde46;SRC	It is suggested that ***pde46*** may be ***associated*** with ***SRC*** family tyrosyl kinases in intact cells and that the ensuing SH3 domain interaction with the LR2 region of pde46 alters the conformation of the PDE catalytic unit , as detected by altered rolipram inhibition .	parallel	0
1848	10206997	6714;5141	SRC;pde46	***Interaction*** between ***pde46*** and ***SRC*** family tyrosyl kinases highlights a potentially novel regulatory system and point of signaling system cross-talk .	parallel	1
1849	10206998	1080;360	cystic fibrosis transmembrane conductance regulator;aquaporin 3	The ***cystic fibrosis transmembrane conductance regulator*** ***activates*** ***aquaporin 3*** in airway epithelial cells .	positive	1
1850	10206998	1080;360	CFTR;aquaporin 3	Glycerol uptake and antisense studies suggest ***CFTR-dependent*** ***regulation*** of ***aquaporin 3*** ( AQP3 ) water channels in airway epithelial cells .	target	1
1851	10206998	1080;360	CFTR;AQP3	These findings indicate that ***CFTR*** is a ***regulator*** of ***AQP3*** in airway epithelial cells .	target	1
1852	10207005	3977;3572	LIFR;gp130	IL-6 ) , whereas CNTF and leukemia inhibitory factor ( LIF ) signal via a ***heterodimer*** of ***gp130*** and LIF receptor ( ***LIFR*** ) .	parallel	1
1853	10207005	3977;3572	LIFR;gp130	The resulting IL-6/CNTF chimera lost the capacity to signal via gp130 on cells without LIFR , but acquired the ability to signal via the ******gp130/LIFR****** ***heterodimer*** and STAT3 on responsive cells .	parallel	1
1854	10207023	7027;1874	DP1;E2F4	Consistent with previous data from human and mouse fibroblasts and T-lymphocytes , ***E2F4*** and ***DP1*** form the predominant E2F ***heterodimers*** both in G0 and G1 phases of the human B-lymphocyte cell cycle , whereas E2F1 and -3 are first detected in late G1 , and their expression levels increase towards S phase .	parallel	1
1855	10207024	155;5594	beta3AR;ERK1/2	***ERK1/2*** ***activation*** by the ***beta3AR*** was insensitive to the cAMP-dependent protein kinase inhibitor H-89 but was abolished by genistein and AG1478 .	positive	1
1856	10207032	3667;3643	IRS-1;insulin receptor	CSF-1-treated adipocytes expressing the CSF1R/IRA960 were impaired in their ability to phosphorylate ***insulin receptor*** ***substrate*** 1 ( ***IRS-1*** ) but not in their ability to phosphorylate IRS-2 .	parallel	1
1857	10207032	3643;8660	insulin receptor;IRS-2	These observations suggest that Tyr960 is important for ***interaction*** of the ***insulin receptor*** cytoplasmic domain with ***IRS-2*** , but it is not essential to the ability of the insulin receptor tyrosine kinase to use IRS-2 as a substrate .	parallel	1
1858	10207032	3643;8660	insulin receptor;IRS-2	These observations also suggest that in 3T3-L1 adipocytes , tyrosine ***phosphorylation*** of ***IRS-2*** by the ***insulin receptor*** tyrosine kinase is not sufficient for maximal stimulation of receptor-regulated glucose transport or glycogen synthesis .	target	1
1859	10207038	3091;405	HIF1alpha;ARNT	The ******HIF1alpha.ARNT****** ***complex*** binds to " hypoxia responsive enhancers " and activates the transcription of genes that regulate adaptation to low oxygen , e.g. erythropoietin ( Epo ) .	parallel	1
1860	10207047	6464;2885	Shc;Grb2	The interactions between Shc , Grb2 , and SHIP are therefore analogous to the ***interactions*** between ***Shc*** , ***Grb2*** , and SOS .	parallel	1
1861	10207051	4193;7161	MDM2;p73	***MDM2*** ***suppresses*** ***p73*** function without promoting p73 degradation .	negative	1
1862	10207051	4193;7161	MDM2;p73	***MDM2*** did not promote the degradation of p73 but instead ***disrupted*** the interaction of ***p73*** , but not of p53 , with p300/CBP by competing with p73 for binding to the p300/CBP N terminus .	negative	0
1863	10207051	7161;4193	p73;MDM2	Hence , ***MDM2*** is transcriptionally ***activated*** by ***p73*** and , in turn , negatively regulates the function of this activator through a mechanism distinct from that used for p53 inactivation .	positive	1
1864	10207052	2547;7520	Ku70;Ku80	The mutational change nonetheless abrogates the ******Ku70-Ku80****** ***interaction*** and DNA end-binding activity .	parallel	1
1865	10207054	3725;1386	c-Jun;ATF2	Similarly , overexpression of ***c-Jun*** in 293T human embryo kidney cells ***increased*** ***ATF2*** ubiquitination in vivo and reduced its half-life in a dose-dependent manner .	positive	0
1866	10207070	8850;3151	PCAF;HMG-17	Specific ***acetylation*** of chromosomal protein ***HMG-17*** by ***PCAF*** alters its interaction with nucleosomes .	target	1
1867	10207070	8850;3151	PCAF;HMG-17	Here we report that ***PCAF*** , a transcription coactivator with intrinsic histone acetyltransferase activity , specifically ***acetylates*** ***HMG-17*** but not HMG-14 .	target	1
1868	10207070	3150;8850	HMG-14;PCAF	Thus , the presence of ***HMG-14*** and HMG-17 ***affects*** the ability of ***PCAF*** to acetylate chromatin , while the acetylation of HMG-17 reduces its binding affinity to chromatin .	target	0
1869	10207070	3151;8850	HMG-17;PCAF	Thus , the presence of HMG-14 and ***HMG-17*** ***affects*** the ability of ***PCAF*** to acetylate chromatin , while the acetylation of HMG-17 reduces its binding affinity to chromatin .	target	0
1870	10207071	2033;1103	p300;ChAT	Overexpression of ***p300*** , a coactivator protein endowed with histone acetyltransferase activity , ***stimulated*** the ***ChAT*** promoter and had a synergistic effect on butyrate treatment .	positive	0
1871	10207072	4790;7157	NF-kappaB;p53	Moreover , endogenous , tumor necrosis factor alpha-activated ***NF-kappaB*** will ***inhibit*** endogenous wild-type ***p53*** transactivation .	negative	1
1872	10207072	2033;1387	p300;CBP	Both p53 and RelA ( p65 ) interact with the transcriptional coactivator proteins p300 and CREB-binding protein ( CBP ) , and we demonstrate that these results are consistent with competition for a limiting pool of ******p300/CBP****** ***complexes*** in vivo .	parallel	1
1873	10207073	1387;2623	CREB-Binding protein;GATA-1	We have previously shown that the transcriptional cofactor ***CREB-Binding protein*** ( CBP ) binds to the zinc finger domain of GATA-1 , markedly ***stimulates*** the transcriptional activity of ***GATA-1*** , and is required for erythroid differentiation .	positive	0
1874	10207073	1387;2623	CBP;GATA-1	Here we report that ***CBP*** , but not p/CAF , ***acetylates*** ***GATA-1*** at two highly conserved lysine-rich motifs present at the C-terminal tails of both zinc fingers .	target	1
1875	10207073	1387;2623	CBP;GATA-1	In addition , we show that ***CBP*** ***stimulates*** ***GATA-1*** acetylation in vivo in an E1A-sensitive manner , thus establishing a correlation between acetylation and transcriptional activity of GATA-1 .	positive	0
1876	10207076	4609;4149	c-Myc;Max protein	We show here that constructs containing the Tmp regulatory region fused to a reporter gene are activated by c-Myc through this CACGTG element and that the ******c-Myc-Max protein****** ***complex*** can bind to this element .	parallel	1
1877	10207078	5594;7153	ERK2;topoisomerase IIalpha	In this study , we demonstrated ***interactions*** between ***ERK2*** and ***topoisomerase IIalpha*** proteins by coimmunoprecipitation from mixtures of purified enzymes and from nuclear extracts .	parallel	1
1878	10207078	5594;7153	ERK;topoisomerase IIalpha	Our findings indicate that ***ERK*** ***regulates*** ***topoisomerase IIalpha*** in vitro and in vivo , suggesting a potential target for the MKK/ERK pathway in the modulation of chromatin reorganization events during mitosis and in other phases of the cell cycle .	target	1
1879	10207085	604;7704	BCL-6;PLZF	In addition , Kaiso homodimerized via its POZ domain but it did not heterodimerize with ***BCL-6*** , which ***heterodimerizes*** with ***PLZF*** .	parallel	1
1880	10207085	1500;10009	p120;Kaiso	The catenin ***p120*** ( ctn ) ***interacts*** with ***Kaiso*** , a novel BTB/POZ domain zinc finger transcription factor .	parallel	1
1881	10207085	1500;10009	p120;Kaiso	Monoclonal antibodies to Kaiso were generated and used to immunolocalize the protein and confirm the specificity of the ******p120-Kaiso****** ***interaction*** in mammalian cells .	parallel	1
1882	10207087	861;2113	AML1;ETS protein	Functional and physical ***interactions*** between ***AML1*** proteins and an ***ETS protein*** , MEF : implications for the pathogenesis of t ( 8 ; 21 ) - positive leukemias .	parallel	1
1883	10207087	865;861	CBFbeta;AML1	The AML1 and ETS families of transcription factors play critical roles in hematopoiesis ; ***AML1*** , and its non-DNA-binding ***heterodimer*** partner ***CBFbeta*** , are essential for the development of definitive hematopoiesis in mice , whereas the absence of certain ETS proteins creates specific defects in lymphopoiesis or myelopoiesis .	parallel	1
1884	10207087	2000;861	MEF;AML1	In this study , we demonstrate direct ***interactions*** between ***MEF*** and ***AML1*** proteins , including the AML1/ETO fusion protein , in t ( 8 ; 21 ) - positive acute myeloid leukemia ( AML ) cells .	parallel	1
1885	10207087	2000;3562	MEF;interleukin 3	***MEF*** and AML1B synergistically ***transactivated*** an ***interleukin 3*** promoter reporter gene construct , yet the activating activity of MEF was abolished when MEF was coexpressed with AML1/ETO .	positive	1
1886	10207089	7040;1021	TGF-beta;Cdk6	While ***TGF-beta*** treatment ***decreased*** the expression of ***Cdk6*** , this effect was counteracted by HGF , followed by partial restoration of cyclin D2-associated kinase activity .	negative	0
1887	10207089	3082;7040	HGF;TGF-beta	Notably , ***HGF*** failed to ***prevent*** ***TGF-beta*** induction of p15 and its association with Cdk6 .	negative	0
1888	10207089	7040;1030	TGF-beta;p15	Notably , HGF failed to prevent ***TGF-beta*** ***induction*** of ***p15*** and its association with Cdk6 .	target	1
1889	10207089	3082;7040	HGF;TGF-beta	However , HGF reversed the TGF-beta-mediated decrease in Cdk6-associated p27 and cyclin D2-associated Cdk6 , suggesting that ***HGF*** ***modifies*** the ***TGF-beta*** response at the level of G1 cyclin complex formation .	target	0
1890	10207094	1869;7157	E2F-1;p53	Upregulation of ***E2F-1*** in response to DNA damage seems to ***require*** the presence of wild-type ***p53*** , since we did not observe an increase in the level of E2F-1 protein in several cell lines which possess mutated p53 .	target	0
1891	10207094	4193;7157	Mdm2;p53	Previous experiments showed that p53 is upregulated after microinjection of an antibody which binds to a domain of Mdm2 that is required for the ***interaction*** of ***Mdm2*** with ***p53*** .	parallel	1
1892	10207094	1869;4193	E2F-1;Mdm2	Recently it has been shown that ***E2F-1*** ***binds*** and coprecipitates with the mouse double-minute chromosome 2 protein ( ***Mdm2*** ) .	parallel	1
1893	10207094	4193;7157	Mdm2;p53	It is known that interaction of Mdm2 with p53 through this domain is required for ***Mdm2-dependent*** ***degradation*** of ***p53*** .	negative	1
1894	10207094	4193;7157	Mdm2;p53	It is known that ***interaction*** of ***Mdm2*** with ***p53*** through this domain is required for Mdm2-dependent degradation of p53 .	parallel	1
1895	10207096	5159;6772	PDGFR;Stat1	Using purified recombinant STAT proteins produced in Escherichia coli , we found that ***Stat1*** could be ***activated*** by immunopurified ***PDGFR*** and showed no additional requirement for membrane - or cytosol-derived proteins .	positive	1
1896	10207096	5159;6772	PDGFR;Stat1	We conclude that the mechanisms of ***activation*** of ***Stat1*** and Stat3 by ***PDGFR*** are distinct .	positive	1
1897	10207096	5159;6774	PDGFR;Stat3	We conclude that the mechanisms of ***activation*** of Stat1 and ***Stat3*** by ***PDGFR*** are distinct .	positive	1
1898	10207097	3097;6925	MIBP1;SEF-2	***MIBP1*** ***interacts*** specifically with both the TC box in the SSTR-2 promoter and with the ***SEF-2*** initiator-binding protein to enhance transcription from the basal SSTR-2 promoter .	parallel	1
1899	10207102	5897;5896	RAG2;RAG1	These results suggest how the heptamer element , the recognition surface essential for DNA cleavage , is recognized by the RAG proteins and have implications for the stoichiometry and active site organization of the ******RAG1-RAG2-RSS****** ***complex*** .	parallel	1
1900	10207103	7409;6478	Vav;hSiah2	We report here the ***interaction*** between ***Vav*** and ***hSiah2*** , a mammalian homolog of Drosophila Seven in absentia ( Sina ) that has been implicated in R7 photoreceptor cell formation during Drosophila eye development via the proteasome degradation pathway .	parallel	1
1901	10207103	7409;6478	Vav;hSiah2	***Vav*** and ***hSiah2*** ***interact*** in vitro and in vivo and colocalize in the cytoplasm of hematopoietic cells .	parallel	1
1902	10207103	6478;5599	hSiah2;JNK	Overexpression of ***hSiah2*** also ***inhibits*** the onco-Vav-induced ***JNK*** activation .	negative	1
1903	10207105	3479;4609	IGF-I;c-myc	Both IL-4 and ***IGF-I*** were able to ***induce*** ***c-myc*** early response gene expression , and this expression was maximal in the presence of both factors .	target	1
1904	10207105	3565;4609	IL-4;c-myc	Both ***IL-4*** and IGF-I were able to ***induce*** ***c-myc*** early response gene expression , and this expression was maximal in the presence of both factors .	target	1
1905	10207105	3565;3479	IL-4;IGF-I	Together , our results suggest that ***IL-4*** ***synergizes*** with ***IGF-I*** for hematopoietic cell proliferation , likely through cross talk between SHC/Grb2/MAPK and STAT6 pathways and through c-myc gene up-regulation .	parallel	0
1906	10207105	2885;6464	Grb2;SHC	***Grb2*** ***association*** with ***SHC*** and mitogen-activated protein kinase ( MAPK ) activity was also enhanced in response to IGF-I stimulation .	parallel	0
1907	10207109	4215;595	MEKK3;cyclin D1	***MEKK3*** critically ***blocks*** mitogen-driven expression of ***cyclin D1*** , a cyclin which is essential for progression of fibroblasts through G1 .	negative	0
1908	10207115	1029;1026	p16;p21	In the parental cells , ***p16*** expression also ***augmented*** total cellular and Cdk2-bound ***p21*** .	positive	0
1909	10207115	1026;1017	p21;Cdk2	These findings indicate that ***p21-mediated*** ***inhibition*** of ***Cdk2*** contributes to the cell cycle arrest imposed by p16 and is a potential point of cooperation between the p16/pRB and p14 ( ARF ) / p53 tumor suppressor pathways .	negative	1
1910	10207115	1029;1029	p16;p14	These findings indicate that p21-mediated inhibition of Cdk2 contributes to the cell cycle arrest imposed by p16 and is a potential point of ***cooperation*** between the ***p16/pRB*** and ***p14*** ( ARF ) / p53 tumor suppressor pathways .	parallel	0
1911	10207115	1029;5925	p16;pRB	These findings indicate that p21-mediated inhibition of Cdk2 contributes to the cell cycle arrest imposed by p16 and is a potential point of ***cooperation*** between the ******p16/pRB****** and p14 ( ARF ) / p53 tumor suppressor pathways .	parallel	0
1912	10207115	5925;1029	pRB;p14	These findings indicate that p21-mediated inhibition of Cdk2 contributes to the cell cycle arrest imposed by p16 and is a potential point of ***cooperation*** between the ***p16/pRB*** and ***p14*** ( ARF ) / p53 tumor suppressor pathways .	parallel	0
1913	10207115	1029;1019	p16;cdk4	In these clones , ***binding*** of ***p16*** to ***cdk4*** and cdk6 abrogated binding of cyclin D1 , p27 ( KIP1 ) , and p21 ( WAF1/CIP1 ) .	parallel	1
1914	10207115	1029;1021	p16;cdk6	In these clones , ***binding*** of ***p16*** to cdk4 and ***cdk6*** abrogated binding of cyclin D1 , p27 ( KIP1 ) , and p21 ( WAF1/CIP1 ) .	parallel	1
1915	10207115	1026;595	p21;cyclin D1	In these clones , binding of p16 to cdk4 and cdk6 abrogated ***binding*** of ***cyclin D1*** , p27 ( KIP1 ) , and ***p21*** ( WAF1/CIP1 ) .	parallel	1
1916	10207115	1026;5715	p21;p27	In these clones , binding of p16 to cdk4 and cdk6 abrogated ***binding*** of cyclin D1 , ***p27*** ( KIP1 ) , and ***p21*** ( WAF1/CIP1 ) .	parallel	1
1917	10207115	5715;595	p27;cyclin D1	In these clones , binding of p16 to cdk4 and cdk6 abrogated ***binding*** of ***cyclin D1*** , ***p27*** ( KIP1 ) , and p21 ( WAF1/CIP1 ) .	parallel	1
1918	10207115	1029;595	p16;cyclin D1	In these clones , binding of ***p16*** to cdk4 and cdk6 ***abrogated*** binding of ***cyclin D1*** , p27 ( KIP1 ) , and p21 ( WAF1/CIP1 ) .	negative	0
1919	10207115	1029;1026	p16;p21	In these clones , binding of ***p16*** to cdk4 and cdk6 ***abrogated*** binding of cyclin D1 , p27 ( KIP1 ) , and ***p21*** ( WAF1/CIP1 ) .	negative	0
1920	10207115	1029;5715	p16;p27	In these clones , binding of ***p16*** to cdk4 and cdk6 ***abrogated*** binding of cyclin D1 , ***p27*** ( KIP1 ) , and p21 ( WAF1/CIP1 ) .	negative	0
1921	10207115	1017;1026	Cdk2;p21	Most cyclin ***E-Cdk2*** complexes ***associated*** with ***p21*** and became inactive , expression of cyclin A was curtailed , and DNA synthesis was strongly inhibited .	parallel	0
1922	10207144	4908;4914	NT-3;TrkA	Expression of Trk receptors in the developing mouse trigeminal ganglion : in vivo evidence for ***NT-3*** ***activation*** of ***TrkA*** and TrkB in addition to TrkC .	positive	1
1923	10207144	4908;4915	NT-3;TrkB	Expression of Trk receptors in the developing mouse trigeminal ganglion : in vivo evidence for ***NT-3*** ***activation*** of TrkA and ***TrkB*** in addition to TrkC .	positive	1
1924	10207166	998;3725	Cdc42;AP-1	Although both Cdc42 and Rho were involved in the shear stress-induced transcription factor AP-1 acting on the 12-O-tetradecanoyl-13-phorbol-acetate-responsive element ( TRE ) , only ***Cdc42*** was sufficient to ***activate*** ***AP-1/TRE*** .	positive	1
1925	10207167	941;942	CD80;CD86	Finally , we demonstrate that the defects in antigen priming are likely due to the lack of CD154 expression and insufficient costimulation of T cells by ******CD80/CD86****** ***interactions*** .	parallel	1
1926	10207506	2690;3952	Growth hormone binding protein;leptin	***Growth hormone binding protein*** ***correlates*** strongly with ***leptin*** and percentage body fat in GH-deficient adults , is increased by GH replacement but does not predict IGF-I response .	parallel	0
1927	10207507	5443;3479	adrenocorticotropin;IGF-I	Long-term administration of ***adrenocorticotropin*** ***modulates*** the expression of ***IGF-I*** and TGF-beta 1 mRNAs in the rat adrenal cortex .	target	0
1928	10207507	5443;7040	adrenocorticotropin;TGF-beta 1	Long-term administration of ***adrenocorticotropin*** ***modulates*** the expression of IGF-I and ***TGF-beta 1*** mRNAs in the rat adrenal cortex .	target	0
1929	10207507	5443;7040	ACTH;TGF-beta 1	***ACTH*** also significantly increased proliferating cell nuclear antigen mRNA level ( P < 0.01 ) , at 4 weeks of treatment , which correlated with IGF-I level ( P < 0.01 ) , but ***correlated*** negatively with ACTH-stimulated ***TGF-beta 1*** level ( P < 0.05 ) .	negative	0
1930	10207507	5443;5111	ACTH;proliferating cell nuclear antigen	***ACTH*** also significantly ***increased*** ***proliferating cell nuclear antigen*** mRNA level ( P < 0.01 ) , at 4 weeks of treatment , which correlated with IGF-I level ( P < 0.01 ) , but correlated negatively with ACTH-stimulated TGF-beta 1 level ( P < 0.05 ) .	positive	0
1931	10207622	5600;7422	SAPK2;vascular endothelial growth factor	In vascular endothelial cells , where the basal level of expression of Hsp27 is high , ***SAPK2*** ***mediates*** oxidative stress - and ***vascular endothelial growth factor*** ( VEGF ) - induced actin reorganization and VEGF-induced cell migration , suggesting a key role for this MAP kinase pathway in inflammation and angiogenic processes .	target	0
1932	10207720	3953;3952	LEPR;leptin	Genes that have been shown to have a regulatory function in the control of body fat utilization , eating behavior , and/or metabolic rate in rodent models of obesity include leptin ( LEP ) , ***leptin*** ***receptor*** ( ***LEPR*** ) , neuropeptide Y ( NPY ) , NPY Y1 receptor ( NPYY1 ) , glucagon-like peptide-1 ( GLP-1 ) , GLP-1 receptor ( GLP1R ) , and uncoupling protein 1 ( UCP1 ) .	parallel	1
1933	10207720	2740;2641	GLP1R;GLP-1	Genes that have been shown to have a regulatory function in the control of body fat utilization , eating behavior , and/or metabolic rate in rodent models of obesity include leptin ( LEP ) , leptin receptor ( LEPR ) , neuropeptide Y ( NPY ) , NPY Y1 receptor ( NPYY1 ) , glucagon-like peptide-1 ( GLP-1 ) , ***GLP-1*** ***receptor*** ( ***GLP1R*** ) , and uncoupling protein 1 ( UCP1 ) .	parallel	1
1934	10207913	2752;113451	glutamate decarboxylase;arginine decarboxylase	In contrast to S. typhimurium , E. coli and Shigella have acid resistance systems induced in complex media that include a glucose-repressed system protective at pH 2.5 without amino acid supplementation , a ***glutamate decarboxylase*** system that ***requires*** glutamate and an ***arginine decarboxylase*** system unique to E. coli .	target	0
1935	10207939	7040;3458	TGF beta;IFN gamma	***TGF beta*** , a known ***inhibitor*** of IL12 and ***IFN gamma*** production , is produced at higher levels by lung cells from those patients who undergo remission of their disease , suggesting that TGF gamma is important in downregulating granulomatous inflammation in sarcoidosis .	negative	1
1936	10208413	5781;6714	Shp-2;Src	The ***Shp-2*** tyrosine phosphatase ***activates*** the ***Src*** tyrosine kinase by a non-enzymatic mechanism .	positive	1
1937	10208413	6714;5781	Src;Shp-2	Previously , we demonstrated that the ***Src*** tyrosine kinase ***interacts*** with the ***Shp-2*** tyrosine phosphatase .	parallel	1
1938	10208413	5781;6714	Shp-2;Src	Our findings reveal that the ***Shp-2*** tyrosine phosphatase can ***regulate*** the ***Src*** tyrosine kinase by a non-enzymatic mechanism .	target	1
1939	10208414	4193;7157	MDM2;p53	p53 mediated death of cells overexpressing MDM2 by an inhibitor of ***MDM2*** ***interaction*** with ***p53*** .	parallel	1
1940	10208414	4193;7027	MDM2;DP1	There is also a decrease in E2F activity , that might have been due to the known physical and functional ***interactions*** of ***MDM2*** with ***E2F1/DP1*** .	parallel	1
1941	10208414	4193;1869	MDM2;E2F1	There is also a decrease in E2F activity , that might have been due to the known physical and functional ***interactions*** of ***MDM2*** with ***E2F1/DP1*** .	parallel	1
1942	10208414	7157;4193	p53;MDM2	These results show that a peptide homologue of p53 is sufficient to induce p53 dependent cell death in cells overexpressing MDM2 , and support the notion that disruption of the ******p53-MDM2****** ***complex*** is a target for the development of therapeutic agents .	parallel	1
1943	10208418	5900;5898	RalGDS;Ral	The small GTP-binding protein ***Ral*** is ***activated*** by ***RalGDS*** , one of the effector molecules for Ras .	positive	1
1944	10208419	9564;1398	p130Cas;Crk	Of these , paxillin and ***p130Cas*** ***interacted*** with ***Crk*** proteins in GDNF-treated neuroblastoma cells .	parallel	1
1945	10208419	5829;1398	paxillin;Crk	Of these , ***paxillin*** and p130Cas ***interacted*** with ***Crk*** proteins in GDNF-treated neuroblastoma cells .	parallel	1
1946	10208422	1874;1869	E2F-4;E2F-1	Our findings indicate that ***E2F-4*** is a critical ***regulator*** of ***E2F-1*** , which offer an excellent paradigm for understanding functional diversity within the E2F family .	target	1
1947	10208422	5934;1874	p130;E2F-4	Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and ******E2F-4/p130****** ***complexes*** .	parallel	1
1948	10208422	5925;1874	pRB;E2F-4	Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of ******E2F-4/pRB****** and E2F-4/p130 ***complexes*** .	parallel	1
1949	10208422	3439;1869	IFN-alpha;E2F-1	In this study , we investigated the mechanisms whereby ***IFN-alpha*** ***suppresses*** transcription of the ***E2F-1*** gene .	negative	1
1950	10208422	3439;1869	IFN-alpha;E2F-1	***IFN-alpha*** markedly ***reduced*** ***E2F-1*** promoter activity , but introduction of non-binding mutation at the E2F sites completely abrogated the inhibition .	negative	1
1951	10208422	1874;5934	E2F-4;p130	IFN-alpha induced upregulation of E2F-4 along with dephosphorylation of pRB and p130 , which resulted in the formation of E2F-4/pRB and ******E2F-4/p130****** ***complexes*** on the E2F-1 promoter .	parallel	1
1952	10208422	1874;5925	E2F-4;pRB	IFN-alpha induced upregulation of E2F-4 along with dephosphorylation of pRB and p130 , which resulted in the formation of ******E2F-4/pRB****** and E2F-4/p130 ***complexes*** on the E2F-1 promoter .	parallel	1
1953	10208422	3439;1874	IFN-alpha;E2F-4	***IFN-alpha*** ***induced*** upregulation of ***E2F-4*** along with dephosphorylation of pRB and p130 , which resulted in the formation of E2F-4/pRB and E2F-4/p130 complexes on the E2F-1 promoter .	target	1
1954	10208424	3976;983	CDF;cdc2	In the present study , we have analysed the effect of the SV40 large T oncoprotein ( SV-LT ) on the function of a different cell cycle-regulated transcriptional repressor , ***CDF*** , which is the principal ***regulator*** of the cdc25C , cyclin A and ***cdc2*** genes .	target	1
1955	10208424	3976;995	CDF;cdc25C	In the present study , we have analysed the effect of the SV40 large T oncoprotein ( SV-LT ) on the function of a different cell cycle-regulated transcriptional repressor , ***CDF*** , which is the principal ***regulator*** of the ***cdc25C*** , cyclin A and cdc2 genes .	target	1
1956	10208426	7040;1026	TGFbeta;p21	Our previous data demonstrated that Ras activation was necessary and sufficient for transforming growth factor-beta ( TGFbeta ) - mediated Erk1 activation , and was required for ***TGFbeta*** ***up-regulation*** of the Cdk inhibitors ( CKI 's ) p27 ( Kip1 ) and ***p21*** ( Cip1 ) ( KM Mulder and SL Morris , J.	positive	1
1957	10208426	7040;4086	TGFbeta;Smad1	We demonstrate that both ***TGFbeta*** and bone morphogenetic protein ( BMP ) can ***induce*** endogenous ***Smad1*** phosphorylation in intestinal epithelial cells ( IECs ) .	target	1
1958	10208427	2885;6654	Grb2;Sos1	However , no significant differences were detected in vivo between Isf I - and Isf II-transfected clones regarding the amount , stability and subcellular localization of ******Sos1-Grb2****** ***complex*** , or the level of hSos1 phosphorylation upon cellular stimulation .	parallel	1
1959	10208430	5884;7157	hRAD17;p53	***hRAD17*** , a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene , ***stimulates*** ***p53*** accumulation .	positive	0
1960	10208431	862;861	ETO;AML1	The ***AMLI/ETO*** fusion protein has been shown to function mainly as a transcriptional repressor of AML1 target genes and to ***block*** ***AML1*** function in vitro and in vivo .	negative	0
1961	10208431	862;861	ETO;AML1	The ***AMLI/ETO*** fusion protein has been shown to function mainly as a transcriptional ***repressor*** of ***AML1*** target genes and to block AML1 function in vitro and in vivo .	negative	1
1962	10208431	861;596	AML1;BCL-2	However , ***AML1/ETO*** can also ***activate*** the ***BCL-2*** promoter and cause enhanced hematopoietic progenitor self-renewal in vitro , suggesting gain-of-functions unique to the fusion protein .	positive	1
1963	10208431	862;596	ETO;BCL-2	However , ***AML1/ETO*** can also ***activate*** the ***BCL-2*** promoter and cause enhanced hematopoietic progenitor self-renewal in vitro , suggesting gain-of-functions unique to the fusion protein .	positive	1
1964	10208431	861;3725	AML1;c-Jun	Expression of ***AML1/ETO*** ***increased*** the level of ***c-Jun-P*** ( ser63 ) , and activated AP-1 dependent transcription , which was inhibited by expression of a dominant-negative c-Jun protein .	positive	0
1965	10208431	862;3725	ETO;c-Jun	Expression of ***AML1/ETO*** ***increased*** the level of ***c-Jun-P*** ( ser63 ) , and activated AP-1 dependent transcription , which was inhibited by expression of a dominant-negative c-Jun protein .	positive	0
1966	10208433	4193;7157	Mdm2;p53	However , the level of active Mdm2 must be controlled carefully : overexpression of ***Mdm2*** ***inhibits*** UV induced ***p53*** stabilization .	negative	1
1967	10208434	8061;2353	Fra-1;c-fos	***Fra-1*** containing AP-1 complexes ***repress*** the ***c-fos*** and possibly other immediate early genes thereby preventing the induction of certain delayed early genes such as the T1 gene in response to mitogenic stimulation .	negative	1
1968	10208434	3727;8061	JunD;Fra1	We show that AP-1 , which is abundant in these cells throughout the whole cell cycle , consists predominantly of Fra-1/c-Jun and ******Fra1/JunD****** ***heterodimers*** .	parallel	1
1969	10208434	8061;3725	Fra1;c-Jun	We provide evidence that ******Fra1/c-Jun****** ***heterodimers*** are responsible for the repression of c-fos gene induction following serum stimulation .	parallel	1
1970	10208467	4323;4313	membrane type 1 matrix metalloproteinase;matrix metalloproteinase-2	***membrane type 1 matrix metalloproteinase*** ***activates*** the latent form of ***matrix metalloproteinase-2*** .	positive	1
1971	10208489	3949;4018	LDLR;lipoprotein	FH is caused by mutations in the low-density ***lipoprotein*** ***receptor*** ( ***LDLR*** ) gene and is characterized by raised plasma LDL-cholesterol , tendon xanthomas , and premature coronary heart disease .	parallel	1
1972	10208489	3949;4018	LDLR;lipoprotein	The fine mapping of LDLR gene close to several highly informative microsatellite markers provide fine mapping details of the LDLR region and additional tools for studies of ***association*** between plasma ***lipoprotein*** levels and ***LDLR*** gene .	parallel	0
1973	10208590	1499;5663	armadillo;PS1	We also found another ***armadillo-protein*** , p0071 , ***interacted*** with ***PS1*** .	parallel	1
1974	10208747	4660;207	myosin phosphatase regulatory subunit;Rac	The Caenorhabditis elegans mel-11 ***myosin phosphatase regulatory subunit*** affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically ***interacts*** with the ***Rac*** signaling pathway .	parallel	1
1975	10208842	3659;3458	IRF-1;IFN-gamma	Taken together , ***IRF-1*** ***mediates*** ***IFN-gamma*** signaling into primary hepatocytes for cell cycle arrest via p53 expression and for apoptosis .	target	0
1976	10208859	1457;373156	CKII;GST	The ***GST-NS5A*** was also ***phosphorylated*** in vitro by the purified casein kinase II ( ***CKII*** ) , a member of the CMCG kinase family .	target	1
1977	10208865	3549;8600	Ihh;OPGL	Our data support the hypothesis that ***Ihh*** stimulated the late-phase chondrogenic differentiation in differentiated ATDC5 cells and ***upregulated*** the gene expression of ***OPGL*** in these cells .	positive	1
1978	10208873	2321;7422	FLT-1;VEGF	We also investigated the expression of vascular endothelial growth factor ( ***VEGF*** ) , placenta growth factor ( PlGF ) and their ***receptor*** ***FLT-1*** .	parallel	1
1979	10208874	3952;5617	leptin;prolactin	The melanocortin 4 receptor mediates ***leptin*** ***stimulation*** of luteinizing hormone and ***prolactin*** surges in steroid-primed ovariectomized rats .	positive	0
1980	10208874	3952;5617	leptin;PRL	These results suggest that the MC4 receptor may be the pivotal subtype of MC receptors mediating the ***leptin*** ***stimulation*** of LH and ***PRL*** surges .	positive	0
1981	10208934	6285;920	Nef;CD4	Human immunodeficiency virus type 1 ( HIV-1 ) ***Nef*** ***down-regulates*** ***CD4*** by triggering rapid endocytosis of cell surface CD4 .	negative	1
1982	10208934	6285;920	Nef;CD4	To better understand how ***Nef*** ***induces*** ***CD4*** down-regulation , we generated a series of Nef mutants with small in-frame deletions in the coding region .	target	1
1983	10208970	183;1906	Angiotensin II;endothelin-1	***Angiotensin II*** ***interacts*** with prostaglandin F2alpha and ***endothelin-1*** as a local luteolytic factor in the bovine corpus luteum in vitro .	parallel	1
1984	10209021	8480;4928	RAE1;NUP98	Both effects are abrogated either by the introduction of point mutations in the GLEBS-like motif or by overexpression of RAE1 , indicating a direct role for RAE1 and the ******NUP98-RAE1****** ***interaction*** in mRNA export .	parallel	1
1985	10209022	7514;10073	CRM1;snurportin 1	However , the ***interaction*** of ***CRM1*** with ***snurportin 1*** differs from that with previously characterized NESs .	parallel	1
1986	10209022	7514;10073	CRM1;snurportin 1	First , ***CRM1*** ***binds*** ***snurportin 1*** 50-fold stronger than the Rev protein and 5,000-fold stronger than the minimum Rev activation domain .	parallel	1
1987	10209033	6347;6348	MCP-1;MIP-1alpha	***Binding*** of labeled ***MCP-1*** and ***MIP-1alpha*** could be inhibited by unlabeled homologous but not heterologous chemokine , and was independent of the presence of heparan sulfate , laminin , or collagen in the subendothelial matrix .	parallel	1
1988	10209040	25;6777	BCR/ABL;STAT5	We show here that ***BCR/ABL*** ***induces*** phosphorylation and activation of ***STAT5*** by a mechanism that requires the BCR/ABL Src homology ( SH ) 2 domain and the proline-rich binding site of the SH3 domain .	target	1
1989	10209040	25;6777	BCR/ABL;STAT5	However , STAT5B-DAM did not rescue the growth factor-independent colony formation of kinase-deficient K1172R ***BCR/ABL*** or the triple mutant Y177F + R522L + Y793F BCR/ABL , both of which also fail to ***activate*** ***STAT5*** .	positive	1
1990	10209040	25;6777	BCR/ABL;STAT5	Together , these data demonstrate that ***STAT5*** ***activation*** by ***BCR/ABL*** is dependent on signaling from more than one domain and document the important role of STAT5-regulated pathways in BCR/ABL leukemogenesis .	positive	1
1991	10209041	10750;3937	Grb2-related adaptor protein;SLP-76	GrpL , a ***Grb2-related adaptor protein*** , ***interacts*** with ***SLP-76*** to regulate nuclear factor of activated T cell activation .	parallel	1
1992	10209041	3937;7409	SLP-76;Vav	SH2 domain-containing protein 76 ( ***SLP-76*** ) ***interacts*** with the guanine nucleotide exchange factor ***Vav*** to activate the nuclear factor of activated cells ( NF-AT ) , and its expression is required for normal T cell development .	parallel	1
1993	10209041	2885;6654	Grb2;Sos1	In contrast , ***Grb2*** can be ***coimmunoprecipitated*** with ***Sos1*** and Sos2 but not with SLP-76 .	parallel	1
1994	10209072	1392;3552	CRF;IL-1alpha	The different ***regulation*** of ***IL-1alpha*** and IL-1beta pro-inflammatory activities by ***CRF*** may attribute special precision and specificity to the neuroendocrine-immune control of inflammatory processes .	target	1
1995	10209072	1392;3553	CRF;IL-1beta	The different ***regulation*** of IL-1alpha and ***IL-1beta*** pro-inflammatory activities by ***CRF*** may attribute special precision and specificity to the neuroendocrine-immune control of inflammatory processes .	target	1
1996	10209101	11215;5501	AKAP220;PP1c	Here , we demonstrate that the PKA-anchoring protein , ***AKAP220*** , ***binds*** ***PP1c*** with a dissociation constant ( KD ) of 12.1 + / - 4 nM in vitro .	parallel	1
1997	10209103	546;5888	Rad54;Rad51	Mouse ***Rad54*** ***affects*** DNA conformation and DNA-damage-induced ***Rad51*** foci formation .	target	0
1998	10209117	998;57126	Cdc42;cell-surface receptor	Inducible ***recruitment*** of ***Cdc42*** or WASP to a ***cell-surface receptor*** triggers actin polymerization and filopodium formation .	target	0
1999	10209123	8615;2804	p115;giantin	In this process , ***p115*** , another coiled-coil protein , is though to ***bind*** to ***giantin*** on vesicles and to GM130 on cisternae , thus acting as a tether holding the two together [ 12 ] [ 13 ] .	parallel	1
2000	10209123	8615;2801	p115;GM130	In this process , ***p115*** , another coiled-coil protein , is though to ***bind*** to giantin on vesicles and to ***GM130*** on cisternae , thus acting as a tether holding the two together [ 12 ] [ 13 ] .	parallel	1
2001	10209263	10413;2222	yAP-1;ERG9	Additionally , the heme activator protein transcription factors HAP1 and HAP2/3/4 , the yeast activator protein transcription factor ***yAP-1*** , and the phospholipid transcription factor complex INO2/4 ***regulate*** ***ERG9*** expression .	target	1
2002	10209275	5502;5327	inhibitor-1;tPA	Plasminogen activator ***inhibitor-1*** ( PAI-1 ) rapidly ***inactivates*** tissue plasminogen activator ( ***tPA*** ) .	negative	1
2003	10209275	5327;5054	tPA;PAI-1	We propose that the antibodies which convert PAI-1 into a substrate for tPA do this by means of preventing the conversion of the initial ******PAI-1/tPA****** ***complex*** into the final complex by sterical intervention .	parallel	1
2004	10209275	5327;5054	tPA;PAI-1	Moreover , the localisation of the binding epitopes on free PAI-1 , as well as on the ******PAI-1/tPA****** ***complex*** , suggests that tPA in the final complex can not be located near helices E and F , as has previously been proposed .	parallel	1
2005	10209302	7124;3667	TNF-alpha;IRS-1	These results suggest that ***TNF-alpha*** ***inhibits*** insulin-stimulated activation of both the tyrosine ***kinase-IRS-1-PI3K-PKCzeta*** pathway and DG-PKC pathway .	negative	1
2006	10209302	7124;5294	TNF-alpha;PI3K	These results suggest that ***TNF-alpha*** ***inhibits*** insulin-stimulated activation of both the tyrosine ***kinase-IRS-1-PI3K-PKCzeta*** pathway and DG-PKC pathway .	negative	1
2007	10209302	7124;5590	TNF-alpha;PKCzeta	These results suggest that ***TNF-alpha*** ***inhibits*** insulin-stimulated activation of both the tyrosine ***kinase-IRS-1-PI3K-PKCzeta*** pathway and DG-PKC pathway .	negative	1
2008	10209447	596;4609	Bcl-2;c-myc	There was no evidence to suggest that ***c-myc*** was ***modulated*** by upregulation of ***Bcl-2*** or p53 inactivation/mutation .	target	0
2009	10209503	7124;7132	TNF-alpha;TNF-RI	***Binding*** of tumour necrosis factor-alpha ( ***TNF-alpha*** ) to ***TNF-RI*** induces caspase ( s ) - dependent apoptosis in human cholangiocarcinoma cell lines .	parallel	1
2010	10209503	7132;7124	TNF-RI;TNF-alpha	These results indicate that the ***interaction*** between ***TNF-alpha*** and ***TNF-RI*** alone generated a sufficient signal to activate a caspase II subfamily-dependent apoptosis in human cholangiocarcinoma cell lines .	parallel	1
2011	10209506	3458;4261	interferon-gamma;CIITA	Here we report that both HLA-DMB mRNA and the protein are expressed in thyrocytes and that ***CIITA*** expression is ***enhanced*** by ***interferon-gamma*** ( IFN-gamma ) treatment and occurs before DMB , Ii and DRA up-regulation , suggesting CIITA expression is a requirement for antigen processing in thyrocytes .	positive	0
2012	10209943	1543;1571	CYP1A1;CYP2E1	Several studies have indicated an ***association*** between variant alleles of the human ***CYP1A1*** , ***CYP2E1*** and GSTM1 genes and lung cancer .	parallel	0
2013	10209959	3817;5502	hK2;inhibitor-1	We show here that ***hK2*** rapidly forms a ***complex*** with plasminogen activator ***inhibitor-1*** ( PAI-1 ) , the primary inhibitor of uPA in tissues .	parallel	1
2014	10209959	3817;5054	hK2;PAI-1	In addition , hK2 inactivated 6 to 7 mol of PAI-1 by cleavage at Arg346-Met347 for every mole of ******hK2-PAI-1****** ***complex*** formed .	parallel	1
2015	10209959	5054;3817	PAI-1;hK2	***PAI-1*** ***inhibited*** ***hK2*** comparably with protein C inhibitor ( PCI ) and at least 20 times more rapidly than alpha1-anti-chymotrypsin ( ACT ) .	negative	1
2016	10209959	3817;5054	hK2;PAI-1	During complex formation , ***hK2*** ***inactivated*** ***PAI-1*** but did not inactivate ACT or PCI .	negative	1
2017	10210201	6714;2934	c-Src;gelsolin	It interacts with phospholipids and we previously showed that phosphatidylinositol 4,5-bisphosphate promotes ***phosphorylation*** of ***gelsolin*** by the tyrosine kinase ***c-Src*** .	target	1
2018	10210201	6714;2934	c-Src;gelsolin	***gelsolin*** ***phosphorylation*** by ***c-Src*** in the presence of lysophosphatidic acid also revealed Tyr438 as the most prominent site .	target	1
2019	10210266	7124;4790	TNF-alpha;NF-kappaB	In the present study , ***NF-kappaB*** was ***activated*** by ***TNF-alpha*** in rat aortic smooth muscle cells as demonstrated by electrophoretic mobility shift assay .	positive	1
2020	10210266	831;4790	calpain inhibitor;NF-kappaB	The activity of NF-kappaB induced by TNF-alpha was blocked by ***calpain inhibitor*** I , a potent ***NF-kappaB*** ***inhibitor*** .	negative	1
2021	10210266	831;4790	calpain inhibitor;NF-kappaB	The activity of ***NF-kappaB*** induced by TNF-alpha was ***blocked*** by ***calpain inhibitor*** I , a potent NF-kappaB inhibitor .	negative	0
2022	10210266	831;4790	calpain inhibitor;NF-kappaB	However , the activation of NF-kappaB was not related to the expression of COX-2 induced by TNF-alpha since ***calpain inhibitor*** I ***blocked*** the activation of ***NF-kappaB*** but not the expression of COX-2 mRNA or protein .	negative	0
2023	10210318	7040;5925	TGF-beta1;pRb	Using anti-retinoblastoma protein ( pRb ) and anti-specific phosphorylated-pRb antibodies , we demonstrated that ***TGF-beta1*** greatly ***inhibited*** ***pRb*** phosphorylation at serine 795 in MV4-11 and Mo7e cells .	negative	1
2024	10210323	3565;3815	IL-4;c-kit	***IL-4*** dose-dependently ***enhanced*** the expression of ***c-kit*** and high-affinity receptor for IgE ( Fc ( epsilon ) RI ) on the cell surface of SCF-cultured BM cells .	positive	0
2025	10210635	7965;7124	p38;TNF-alpha	***p38*** MAPK inhibition ***decreases*** ***TNF-alpha*** production and enhances postischemic human myocardial function .	positive	0
2026	10210635	7965;7124	p38;TNF-alpha	RESULTS : I/R increased human myocardial TNF-alpha levels from 26.9 + / - 9.3 to 83.9 + / - 19.2 pg/g wet tissue ( P < 0.05 perfusion vs I/R ; ANOVA Bonferroni/Dunn ) , while ***p38*** MAPK inhibition ***decreased*** post-I/R myocardial ***TNF-alpha*** levels to 32.3 + / - 8.0 pg/g wet tissue ( P > 0.05 p38 MAPK inhibition vs I/R ) .	positive	0
2027	10210635	7965;7124	p38;TNF-alpha	CONCLUSIONS : ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) ***p38*** MAPK ***mediates*** myocardial I/R-induced ***TNF-alpha*** production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia-induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation .	target	0
2028	10210639	3667;3643	IRS-1;insulin receptor	Insulin regulates hepatocellular metabolism and growth following insulin receptor ( IR ) autophosphorylation and activation of the intracellular adapter protein , ***insulin receptor*** ***substrate*** 1 ( ***IRS-1*** ) .	parallel	1
2029	10210643	7124;4792	TNF-alpha;IkappaB-alpha	RESULTS : ***TNF-alpha*** ***induced*** ***IkappaB-alpha*** phosphorylation and degradation , which was inhibited by NaSal in both cell lines .	target	1
2030	10210772	3572;3569	gp130;IL-6	Soluble ***gp130*** had already been shown to ***inhibit*** ***IL-6*** signaling by inactivating the IL-6/IL -6 R complex .	negative	1
2031	10210774	3557;3553	IL-1Ra;IL-1beta	Intra-hypothalamic infusion of IL-1-receptor antagonist ***IL-1Ra*** ( 2 mug/rat ) ***prevented*** this effect of ***IL-1beta*** , but not that of IL-6 , suggesting an IL-1beta-independent mechanism for hypothalamic 5-HT release by this latter cytokine .	negative	0
2032	10210778	3574;3106	IL-7;MHC class I molecule	In AML and ALL , ***IL-7*** ***increased*** ***MHC class I molecule*** expression , while class II molecules were weakly modified .	positive	0
2033	10211111	356;355	FasL;Fas	***Fas*** ***ligand*** ( ***FasL*** ) kills sensitive Fas receptor ( FasR ) - bearing cells by inducing apoptosis .	parallel	1
2034	10211118	8731;3082	Met;HGF	***Met*** protein encoded by Met oncogene is the high affinity ***receptor*** for hepatocyte growth factor ( ***HGF*** ) / scatter factor ( SF ) .	parallel	1
2035	10211120	6382;2247	Syndecan-1;bFGF	***Syndecan-1*** ***binds*** basic fibroblast growth factor ( ***bFGF*** ) , modulates neovascularization , plays a role in epithelial differentiation and is up-regulated by WT1 .	parallel	1
2036	10211121	2321;7422	Flt-1;vascular endothelial growth factor	The immunolocalization and gene expression of ***vascular endothelial growth factor*** ( VEGF ) and its cognate tyrosine kinase ***receptors*** , ***Flt-1*** and KDR , has been studied in ocular melanomas and retinoblastomas using in situ hybridization and immunohistochemistry .	parallel	1
2037	10211121	3791;7422	KDR;vascular endothelial growth factor	The immunolocalization and gene expression of ***vascular endothelial growth factor*** ( VEGF ) and its cognate tyrosine kinase ***receptors*** , Flt-1 and ***KDR*** , has been studied in ocular melanomas and retinoblastomas using in situ hybridization and immunohistochemistry .	parallel	1
2038	10211790	3565;3558	IL-4;IL-2	By contrast , ***IL-4*** ***reduced*** the ***IL-2*** , IL-12 , and IFN-alpha-induced ADCC .	negative	1
2039	10211878	1604;976	CD55;CD97	Expression of the activation antigen ***CD97*** and its ***ligand*** ***CD55*** in rheumatoid synovial tissue .	parallel	1
2040	10211878	1604;976	CD55;CD97	Recently , it was found that ***CD55*** is a specific cellular ***ligand*** for the 7-span transmembrane receptor ***CD97*** .	parallel	1
2041	10211885	3586;5321	IL-10;cPLA2	IL-4 , IL-10 , and IL-13 reduced the TNFalpha-induced COX-2 level , and IL-4 and ***IL-10*** ***reduced*** the ***cPLA2*** level .	negative	1
2042	10211885	3565;5321	IL-4;cPLA2	IL-4 , IL-10 , and IL-13 reduced the TNFalpha-induced COX-2 level , and ***IL-4*** and IL-10 ***reduced*** the ***cPLA2*** level .	negative	1
2043	10211885	3586;5743	IL-10;COX-2	IL-4 , ***IL-10*** , and IL-13 ***reduced*** the TNFalpha-induced ***COX-2*** level , and IL-4 and IL-10 reduced the cPLA2 level .	negative	1
2044	10211885	3596;5743	IL-13;COX-2	IL-4 , IL-10 , and ***IL-13*** ***reduced*** the TNFalpha-induced ***COX-2*** level , and IL-4 and IL-10 reduced the cPLA2 level .	negative	1
2045	10211885	3565;5743	IL-4;COX-2	***IL-4*** , IL-10 , and IL-13 ***reduced*** the TNFalpha-induced ***COX-2*** level , and IL-4 and IL-10 reduced the cPLA2 level .	negative	1
2046	10211885	7124;4790	TNFalpha;NF-kappaB	IL-4 had no effect on ***TNFalpha*** ***up-regulation*** of ***NF-kappaB*** , and a slight decrease was noted with IL-10 and IL-13 at the highest concentration used ( 5 ng/ml ) .	positive	1
2047	10211966	4214;3725	MEKK1;AP-1	IE1-driven activation of ***AP-1*** was ***increased*** dramatically by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 ( ***MEKK1*** ) .	positive	0
2048	10211994	3791;7422	KDR;Vascular endothelial growth factor	***Vascular endothelial growth factor*** and its ***receptor*** , ***KDR*** , in human brain tissue after ischemic stroke .	parallel	1
2049	10211995	3082;3791	HGF;flk-1	This effect would be enhanced by an increased responsiveness of endothelial cells toward VEGF , resulting from the ***HGF/SF-induced*** ***up-regulation*** of ***flk-1*** on these cells .	positive	1
2050	10211995	3082;5502	Hepatocyte growth factor;inhibitor-1	***Hepatocyte growth factor*** ***increases*** expression of vascular endothelial growth factor and plasminogen activator ***inhibitor-1*** in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells .	positive	0
2051	10211995	3082;7422	Hepatocyte growth factor;vascular endothelial growth factor	***Hepatocyte growth factor*** ***increases*** expression of ***vascular endothelial growth factor*** and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells .	positive	0
2052	10211995	3082;3791	Hepatocyte growth factor;flk-1	***Hepatocyte growth factor*** ***increases*** expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor ***flk-1*** in human endothelial cells .	positive	0
2053	10211995	3082;3791	HGF;flk-1	Furthermore , we demonstrate that ***HGF/SF*** ***increases*** the expression of the VEGF receptor ***flk-1*** in human endothelial cells and that , in an angiogenesis co-culture assay of endothelial cells and keratinocytes , HGF/SF increases endothelial cell tube formation significantly .	positive	0
2054	10212141	6294;3178	HAP;hnRNP A1	In in vitro pull-down assays , ***HAP*** ***interacts*** with ***hnRNP A1*** , through its S/K-R/E-rich region , and with several other hnRNPs .	parallel	1
2055	10212189	5594;7157	p38;p53	***p38*** kinase ***mediates*** UV-induced phosphorylation of ***p53*** protein at serine 389 .	target	0
2056	10212189	5594;7157	p38;p53	Here , we report that the UV-induced phosphorylation of ***p53*** at serine 389 is ***mediated*** by ***p38*** kinase .	target	0
2057	10212189	5594;7157	p38;p53	Most importantly , ***p38*** kinase could be ***co-immunoprecipitated*** with ***p53*** by using antibodies against p53 .	parallel	1
2058	10212194	5321;5320	cPLA2;sPLA2	Collectively , the results suggest a model whereby ***cPLA2*** activation ***regulates*** Group V ***sPLA2*** expression , which in turn is responsible for delayed PGE2 production via COX-2 .	target	1
2059	10212207	6714;5747	Src;FAK	Together , these results strongly suggest that PI3K binding is required for FAK to promote cell migration and that the ***binding*** of ***Src*** and p130 ( Cas ) to ***FAK*** may not be sufficient for this event .	parallel	1
2060	10212213	2534;5781	Fyn;SHP-2	Therefore , we have demonstrated for the first time that the activation of SHP-2 by these Gi protein-coupled receptors requires Fyn kinase and that there is a specific physical ***interaction*** of ***Fyn*** kinase with ***SHP-2*** in MDCK cells .	parallel	1
2061	10212213	5781;2534	SHP-2;Fyn	Therefore , we have demonstrated for the first time that the activation of ***SHP-2*** by these Gi protein-coupled receptors ***requires*** ***Fyn*** kinase and that there is a specific physical interaction of Fyn kinase with SHP-2 in MDCK cells .	target	0
2062	10212213	2534;5781	Fyn;SHP-2	***Fyn*** kinase-directed ***activation*** of SH2 domain-containing protein-tyrosine phosphatase ***SHP-2*** by Gi protein-coupled receptors in Madin-Darby canine kidney cells .	positive	1
2063	10212213	2885;5781	Grb2;SHP-2	The agonist-induced direct ***interaction*** of ***Grb2*** with ***SHP-2*** is mediated by the SH2 domain of Grb2 and the tyrosine phosphorylation of SHP-2 .	parallel	1
2064	10212213	5781;2885	SHP-2;Grb2	Pertussis toxin , PP1 ( a selective Src family kinase inhibitor ) , or overexpression of a catalytically inactive mutant of Fyn blocked the UK14304 - or LPA-stimulated activity of SHP-2 , SHP-2 tyrosine phosphorylation , and ***SHP-2*** ***association*** with ***Grb2*** .	parallel	0
2065	10212223	5803;4192	PTPzeta;midkine	A receptor-like protein-tyrosine phosphatase ***PTPzeta/RPTPbeta*** ***binds*** a heparin-binding growth factor ***midkine*** .	parallel	1
2066	10212223	4192;5803	midkine;PTPzeta	In this study , we examined the ***binding*** of ***midkine*** to ***PTPzeta*** by solid-phase binding assay .	parallel	1
2067	10212223	5764;4192	pleiotrophin;midkine	***midkine*** and pleiotrophin binding to PTPzeta were equally ***inhibited*** by soluble ***pleiotrophin*** and also by some specific glycosaminoglycans .	negative	1
2068	10212223	5803;4192	PTPzeta;midkine	These results suggested that ***PTPzeta*** is a common ***receptor*** for ***midkine*** and pleiotrophin .	parallel	1
2069	10212223	5803;5764	PTPzeta;pleiotrophin	These results suggested that ***PTPzeta*** is a common ***receptor*** for midkine and ***pleiotrophin*** .	parallel	1
2070	10212230	3458;4843	IFN-gamma;iNOS	Poly IC + ***IFN-gamma*** ***stimulates*** ***iNOS*** expression and inhibits insulin secretion by primary beta-cells purified by fluorescence-activated cell sorting .	positive	0
2071	10212239	4214;3725	MEK kinase 1;c-Jun	***MEK kinase 1*** ( MEKK1 ) ***transduces*** ***c-Jun*** NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton .	positive	1
2072	10212258	5888;472	Rad51;ATM	Radiation-induced assembly of ***Rad51*** and Rad52 recombination complex ***requires*** ***ATM*** and c-Abl .	target	0
2073	10212258	5888;25	Rad51;c-Abl	Radiation-induced assembly of ***Rad51*** and Rad52 recombination complex ***requires*** ATM and ***c-Abl*** .	target	0
2074	10212258	25;5888	c-Abl;Rad51	Consistent with the physical interaction , ***c-Abl*** ***phosphorylates*** ***Rad51*** in vitro and in vivo .	target	1
2075	10212258	25;5888	c-Abl;Rad51	In assays using purified components , ***phosphorylation*** of ***Rad51*** by ***c-Abl*** enhances complex formation between Rad51 and Rad52 , which cooperates with Rad51 in recombination and repair .	target	1
2076	10212258	5893;5888	Rad52;Rad51	In assays using purified components , phosphorylation of Rad51 by c-Abl enhances complex ***formation*** between ***Rad51*** and ***Rad52*** , which cooperates with Rad51 in recombination and repair .	parallel	0
2077	10212258	5893;5888	Rad52;Rad51	After I-R , an increase in ***association*** between ***Rad51*** and ***Rad52*** occurs in wild-type cells but not in cells with mutations that compromise ATM or c-Abl .	parallel	0
2078	10212267	3976;140628	leukemia inhibitory factor;GATA-5	Last , ***leukemia inhibitory factor*** stimulation markedly ***increased*** transcripts of cardiac ***GATA-5*** , the expression of which is normally restricted to the early embryo .	positive	0
2079	10212268	6722;2626	serum response factor;GATA-4	Gel mobility shift assay supershift analysis demonstrated that the ***serum response factor*** ***binds*** to the CArG element and ***GATA-4*** binds to the GATA element .	parallel	1
2080	10212269	2252;2255	FGF-7;FGF-10	Although ***FGF-10*** and ***FGF-7*** ***bind*** and activate the same resident epithelial cell receptor ( FGFR2IIIb ) , differences in cell type of origin , compartmentation by alternate translation , the affinity for FGFR1IIIb , and access to FGFR by differential interaction with pericellular matrix heparan sulfate suggest they may play both independent and compensatory roles in prostate homeostasis .	parallel	1
2081	10212279	4036;7038	Megalin;thyroglobulin	We recently reported that ***Megalin*** ( gp330 ) , an endocytic receptor found on the apical surface of thyroid cells , ***binds*** ***thyroglobulin*** ( Tg ) with high affinity in solid phase assays .	parallel	1
2082	10212281	6900;3567	Tax1;IL-5	The synergism of GATA3 with either Ets1 or Ets2 may play an important role in calcium - or ***Tax1-dependent*** ***regulation*** of ***IL-5*** expression in Th2 cells or in HTLV-I transformed adult T-cell leukemia cells , respectively .	target	1
2083	10212281	2113;3567	Ets1;IL-5	Studying the regulation of IL-5 gene expression by Ets transcription factors , we found that ***Ets1*** and Ets2 , but not Elf-1 , were able to ***activate*** the human ***IL-5*** promoter in Jurkat T-cells .	positive	1
2084	10212281	2114;3567	Ets2;IL-5	Studying the regulation of IL-5 gene expression by Ets transcription factors , we found that Ets1 and ***Ets2*** , but not Elf-1 , were able to ***activate*** the human ***IL-5*** promoter in Jurkat T-cells .	positive	1
2085	10212281	2113;3567	Ets1;IL-5	In myeloid Kasumi cells , ***Ets1*** and Ets2 failed to ***stimulate*** ***IL-5*** promoter activity , unless the T-cell specific transcription factor GATA3 was added .	positive	0
2086	10212281	2114;3567	Ets2;IL-5	In myeloid Kasumi cells , Ets1 and ***Ets2*** failed to ***stimulate*** ***IL-5*** promoter activity , unless the T-cell specific transcription factor GATA3 was added .	positive	0
2087	10212281	6900;2625	Tax1;GATA3	Both ionomycin and ***Tax1*** ***increased*** the combined effect of ***GATA3*** with Ets1 and Ets2 in the presence of PMA .	positive	0
2088	10212304	2208;7124	CD23;tumor necrosis factor-alpha	***FcepsilonRII/CD23*** is expressed in Parkinson 's disease and ***induces*** , in vitro , production of nitric oxide and ***tumor necrosis factor-alpha*** in glial cells .	target	1
2089	10212304	3458;2208	interferon-gamma;CD23	We show that , in vitro , ***interferon-gamma*** ( IFN-gamma ) together with interleukin-1beta ( Il-1beta ) and tumor necrosis factor-alpha ( TNF-alpha ) can ***induce*** the expression of ***CD23*** in glial cells .	target	1
2090	10212315	3976;627	Leukemia inhibitory factor;neurotrophin	***Leukemia inhibitory factor*** ***augments*** ***neurotrophin*** expression and corticospinal axon growth after adult CNS injury .	positive	0
2091	10212382	83716;5340	trypsin inhibitor;plasmin	Catalytic activity of human ***plasmin*** is ***inhibited*** by bovine basic pancreatic ***trypsin inhibitor*** ( BPTI , also known as aprotinin ) .	negative	1
2092	10212448	7039;1956	transforming growth factor alpha;epidermal growth factor receptor	We conclude by discussing applications of the result to the particular case of the ***transforming growth factor alpha*** ***binding*** to ***epidermal growth factor receptor*** in epidermal wound healing .	parallel	1
2093	10213083	7040;1000	TGF-beta1;N-cadherin	Expression of ***N-cadherin*** , N-CAM , fibronectin and tenascin is ***stimulated*** by ***TGF-beta1*** , beta2 , beta3 and beta5 during the formation of precartilage condensations .	positive	0
2094	10213083	7040;1000	TGF-beta1;N-cadherin	Results showed that ***TGF-beta1*** , TGF-beta2 , TGF-beta3 , and TGF-beta5 differentially ***enhanced*** the expression of ***N-cadherin*** , N-CAM , fibronectin and tenascin in precartilage condensations , suggesting that TGF-beta isoforms play an important role in the establishment of cell-cell and cell-extracellular matrix interactions during precartilage condensations .	positive	0
2095	10213083	7042;1000	TGF-beta2;N-cadherin	Results showed that TGF-beta1 , ***TGF-beta2*** , TGF-beta3 , and TGF-beta5 differentially ***enhanced*** the expression of ***N-cadherin*** , N-CAM , fibronectin and tenascin in precartilage condensations , suggesting that TGF-beta isoforms play an important role in the establishment of cell-cell and cell-extracellular matrix interactions during precartilage condensations .	positive	0
2096	10213083	7043;1000	TGF-beta3;N-cadherin	Results showed that TGF-beta1 , TGF-beta2 , ***TGF-beta3*** , and TGF-beta5 differentially ***enhanced*** the expression of ***N-cadherin*** , N-CAM , fibronectin and tenascin in precartilage condensations , suggesting that TGF-beta isoforms play an important role in the establishment of cell-cell and cell-extracellular matrix interactions during precartilage condensations .	positive	0
2097	10213189	4804;627	p75NTR;neurotrophin	To localize neurotrophin binding sites within the rat dentate gyrus , the distribution of low-affinity p75 ***neurotrophin*** ***receptor*** ( ***p75NTR*** ) immunoreactivity ( IR ) was examined by using antiserum raised against the cytoplasmic domain of the receptor .	parallel	1
2098	10213232	7157;4292	p53;hMLH1	***Cooperation*** between ***p53*** and ***hMLH1*** in a human colocarcinoma cell line in response to DNA damage .	parallel	0
2099	10213385	4487;652	Msx-1;Bmp-4	In the maxillary primordia , mesenchymal expression of Barx-1 is complementary to that of ***Msx-1*** , which ***correlate*** with overlying epithelial expression of FGF-8 and ***Bmp-4*** , respectively .	parallel	0
2100	10213385	4487;2253	Msx-1;FGF-8	In the maxillary primordia , mesenchymal expression of Barx-1 is complementary to that of ***Msx-1*** , which ***correlate*** with overlying epithelial expression of ***FGF-8*** and Bmp-4 , respectively .	parallel	0
2101	10213385	2253;56033	FGF-8;Barx-1	This suggests that in vivo , ***FGF-8/BMP*** signaling may ***regulate*** ***Barx-1*** gene expression .	target	1
2102	10213514	7157;672	p53;BRCA1	Our data indicate that a ***BRCA1*** breast cancer phenotype may be ***recognized*** by an exceptionally high proliferation rate and early and frequent ***p53*** overexpression but infrequent selection for overexpression of several other prognostic factor proteins known to be involved in breast oncogenesis .	target	1
2103	10213614	5900;5898	RalGDS;Ral	***RalGDS*** is a guanine nucleotide dissociation ***stimulator*** for ***Ral*** , and one of its homologues is RGL ( RalGDS-like ) .	positive	0
2104	10213692	9978;997	Rbx1;Cdc34	***Rbx1*** ***promotes*** association of ***Cdc34*** with Cdc53 and stimulates Cdc34 auto-ubiquitination in the context of Cdc53 or SCF complexes .	positive	0
2105	10213914	3558;1392	IL-2;CRH	***IL-2*** ( 10 ( -13 ) M ) ***stimulation*** of ***CRH*** release was unaffected by the lower concentration of ACH ( 10 ( -9 ) M ) , but surprisingly was inhibited by a 100-fold higher concentration .	positive	0
2106	10213916	7349;1392	Urocortin;CRH	***Urocortin*** , a newly isolated 40-amino-acid mammalian peptide homologous to corticotropin-releasing hormone ( CRH ) , ***activates*** both ***CRH*** type 1 and 2 receptors , but may be an endogenous ligand for CRH receptor type 2 .	positive	1
2107	10214348	1869;1029	E2F-1;p19	At other sites where ***E2F-1*** levels ***induce*** ***p19*** , which stabilizes p53 leading to apoptosis , E2F-1 overexpression may lead to tissue atrophy and loss of expression may lead to hyperplasia or tumors .	target	1
2108	10214348	1029;7157	p19;p53	At other sites where E2F-1 levels induce ***p19*** , which ***stabilizes*** ***p53*** leading to apoptosis , E2F-1 overexpression may lead to tissue atrophy and loss of expression may lead to hyperplasia or tumors .	positive	0
2109	10214865	5594;5595	ERK2;ERK1	***ERK2*** phosphorylation was tightly ***correlated*** with ***ERK1*** phosphorylation and MAP kinase activity detected by in vitro kinase assay .	parallel	0
2110	10214867	5524;3684	PP2A;CD11b	Activities of PP1 and ***PP2A*** of AML blasts ***correlated*** positively with the expression of ***CD11b*** , whereas activities of PP1 and PP2B correlated negatively with the expression of CD7 .	positive	0
2111	10214908	7508;5887	XPC;hHR23B	For the bulk of mammalian DNA , the core protein factors needed for damage recognition and incision during nucleotide excision repair ( NER ) are the XPA protein , the heterotrimeric RPA protein , the 6 to 9-subunit TFIIH , the ******XPC-hHR23B****** ***complex*** , the XPG nuclease , and the ERCC1-XPF nuclease .	parallel	1
2112	10214914	7157;5888	p53;Rad51	Complex regulation of HRR by cell cycle checkpoint and surveillance functions is suggested not only by direct ***interactions*** between human ***Rad51*** and ***p53*** , c-Abl , and BRCA2 , but also by very high recombination rates in p53-deficient cells .	parallel	1
2113	10214915	10111;4361	hRad50;hMre11	Two ( sub - ) pathways can be distinguished , the first mediated by DNA-PK-dependent protein kinase ( DNA-PK ) , and the second directed by the ******hMre11/hRad50****** ***complex*** .	parallel	1
2114	10214941	10972;10959	p23;p24	***p24*** and ***p23*** , the major transmembrane proteins of COPI-coated transport vesicles , form hetero-oligomeric ***complexes*** and cycle between the organelles of the early secretory pathway .	parallel	1
2115	10214941	10959;10972	p24;p23	Taken together ***p24*** ***interacts*** with ***p23*** and constitutively cycles between the organelles of the early secretory pathway .	parallel	1
2116	10215323	183;7422	Angiotensin II;vascular endothelial growth factor	***Angiotensin II*** ***stimulates*** the synthesis and secretion of ***vascular permeability factor/vascular endothelial growth factor*** in human mesangial cells .	positive	0
2117	10215594	2641;5105	glucagon;PCK1	These experiments suggested that the CRE1 but not the putative CRE2 was an essential site necessary for the cAMP-mediated ***PCK1*** gene ***activation*** by ***glucagon*** and that the putative CRE2 site was involved in the oxygen-dependent modulation of PCK1 gene activation .	positive	1
2118	10215617	4803;1191	Nerve growth factor;clusterin	***Nerve growth factor*** and epidermal growth factor ***stimulate*** ***clusterin*** gene expression in PC12 cells .	positive	0
2119	10215617	4803;1191	NGF;clusterin	***NGF*** ***induced*** ***clusterin*** mRNA , which preceded neurite outgrowth typical of neuronal differentiation .	target	1
2120	10215635	3558;4051	Interleukin-2;cytochrome P-450	***Interleukin-2*** overexpresses c-myc and ***down-regulates*** ***cytochrome P-450*** in rat hepatocytes .	negative	1
2121	10215635	3558;4051	Interleukin-2;cytochrome P-450	The interaction of ***Interleukin-2*** ( IL-2 ) with its receptor ( IL-2R ) ***decreases*** ***cytochrome P-450*** ( CYP ) expression in rat hepatocytes .	negative	0
2122	10215635	3558;4609	IL-2;c-myc	Because IL-2 increases c-myc in lymphocytes and because c-myc overexpression represses several genes , we postulated that the ***IL-2/IL*** -2 R interaction may ***increase*** ***c-myc*** and thereby down-regulate CYP in hepatocytes .	positive	0
2123	10215635	3558;4609	IL-2;c-myc	Because ***IL-2*** ***increases*** ***c-myc*** in lymphocytes and because c-myc overexpression represses several genes , we postulated that the IL-2/IL -2 R interaction may increase c-myc and thereby down-regulate CYP in hepatocytes .	positive	0
2124	10215635	3558;1576	IL-2;CYP3A	***IL-2*** increased c-myc mRNA and protein but ***decreased*** total CYP and the mRNAs and proteins of CYP2C11 and ***CYP3A*** .	negative	0
2125	10215635	3558;4609	IL-2;c-myc	***IL-2*** ***increased*** ***c-myc*** mRNA and protein but decreased total CYP and the mRNAs and proteins of CYP2C11 and CYP3A .	positive	0
2126	10215647	5742;5743	Cox-1;Cox-2	Healthy older adults ( n = 36 ) were admitted to a clinical research unit , placed on a fixed sodium intake , and randomized under double-blind conditions to receive the specific ***Cox-2*** ***inhibitor*** , MK-966 ( 50 mg every day ) , a nonspecific ***Cox-1*** / Cox-2 inhibitor , indomethacin ( 50 mg t.i.d. ) , or placebo for 2 weeks .	negative	1
2127	10215868	4792;4790	IkappaBalpha;NFkappaB	IRF-1 by itself initiates NFkappaB activation by inducing a reduction in cellular ***MAD3/IkappaBalpha*** , an ***inhibitor*** of ***NFkappaB*** .	negative	1
2128	10215868	4790;3659	NFkappaB;IRF-1	After nuclear translocation , ***NFkappaB*** ***synergizes*** with ***IRF-1*** on the cis-elements positive regulatory domain ( PRD ) II and PRDI/III to induce transcription of the IFN-beta gene .	parallel	0
2129	10215868	4790;3456	NFkappaB;IFN-beta	After nuclear translocation , ***NFkappaB*** synergizes with IRF-1 on the cis-elements positive regulatory domain ( PRD ) II and PRDI/III to ***induce*** transcription of the ***IFN-beta*** gene .	target	1
2130	10215868	1386;3725	ATF-2;c-Jun	In contrast with IFN-beta transcription induced by dsRNA or virus , ******c-Jun/ATF-2****** ***binding*** to PRDIV is not involved .	parallel	1
2131	10215868	5610;4792	PKR;IkappaBalpha	IRF-1-dependent MAD3/IkappaBalpha degradation is not detectable in cells expressing a dominant negative mutant of the protein kinase PKR , suggesting that ***PKR*** ***mediates*** ***MAD3/IkappaBalpha*** degradation .	target	0
2132	10215876	10944;7374	small acidic protein;uracil DNA glycosylase	The equilibrium unfolding of ***uracil DNA glycosylase*** ***inhibitor*** ( Ugi ) , a ***small acidic protein*** of molecular mass 9474 Da , has been studied by a combination of thermal-induced and guanidine hydrochloride ( GdnCl ) - induced denaturation .	negative	1
2133	10215909	627;4842	BDNF;Neuronal NOS	Addition of ***BDNF*** ***upregulated*** the ***Neuronal NOS*** expression as well as NO production in neocortical culture .	positive	1
2134	10215917	627;5327	BDNF;tPA	Here , we report that ***BDNF*** ***stimulates*** the expression of tissue-type plasminogen activator ( ***tPA*** ) in primary cultures of cortical neurons in a time - and concentration-dependent manner .	positive	0
2135	10215917	4909;5327	neurotrophin-4;tPA	Among the other members of the neurotrophin family , ***neurotrophin-4*** ( NT-4 ) and to a lesser extent neurotrophin-3 ( NT-3 ) also ***increased*** ***tPA*** mRNA expression , while nerve growth factor ( NGF ) was devoid of any effect .	positive	0
2136	10215917	627;5327	BDNF;tPA	***Induction*** of ***tPA*** expression by ***BDNF*** is accompanied by an increase in the proteolytic activity of tPA associated with cortical neurons and a release of tPA into the extracellular space .	target	1
2137	10215917	5055;5327	PAI-2;tPA	Up-regulation of tPA expression by BDNF is followed by the induction of plasminogen activator inhibitor 2 ( ***PAI-2*** ) , an ***inhibitor*** of ***tPA*** .	negative	1
2138	10215917	627;5327	BDNF;tPA	***Up-regulation*** of ***tPA*** expression by ***BDNF*** is followed by the induction of plasminogen activator inhibitor 2 ( PAI-2 ) , an inhibitor of tPA .	positive	1
2139	10215917	627;5327	BDNF;tPA	Together these results suggest that ***activation*** of ***tPA*** by ***BDNF*** may contribute to structural changes associated with neuronal development or synaptic plasticity .	positive	1
2140	10215918	4908;4852	neurotrophin-3;NPY	Application of exogenous ***neurotrophin-3*** ( NT-3 ) ***increased*** ***NPY*** and somatostatin protein levels in long-term but not short-term cultures , while nerve growth factor ( NGF ) had no effect .	positive	0
2141	10215918	4908;6750	neurotrophin-3;somatostatin	Application of exogenous ***neurotrophin-3*** ( NT-3 ) ***increased*** NPY and ***somatostatin*** protein levels in long-term but not short-term cultures , while nerve growth factor ( NGF ) had no effect .	positive	0
2142	10215920	4804;627	p75NTR;neurotrophin	Neurotrophins exert their biological functions on neuronal cells through two types of receptors , the trk tyrosine kinases and the low-affinity ***neurotrophin*** ***receptor*** ( ***p75NTR*** ) , which can bind all neurotrophins with similar affinity .	parallel	1
2143	10215920	4803;627	NGF;brain-derived neurotrophic factor	***NGF*** ***antagonizes*** ***brain-derived neurotrophic factor*** ( BDNF ) - and neurotrophin-3 ( NT-3 ) - mediated survival in control but not p75NTR-deficient motoneurons .	negative	1
2144	10215920	4803;4908	NGF;neurotrophin-3	***NGF*** ***antagonizes*** brain-derived neurotrophic factor ( BDNF ) - and ***neurotrophin-3*** ( NT-3 ) - mediated survival in control but not p75NTR-deficient motoneurons .	negative	1
2145	10216092	2812;2815	GPIbbeta;GPIX	Thus , a deletion of one copy of GPIbbeta and a single nucleotide deletion in the codon for Ala 80 within the remaining GPIbbeta allele causes the Bernard-Soulier phenotype through an ***interaction*** of ***GPIbbeta*** with ***GPIX*** resulting in the absence of GPIbalpha on the plasma membrane .	parallel	1
2146	10216092	2812;2815	GPIbbeta;GPIX	The ***interaction*** of ***GPIbbeta*** with ***GPIX*** is essential for the functional expression of GPIbalpha .	parallel	1
2147	10216102	355;356	CD95;CD95 ligand	Because apoptosis induced by anticancer drugs has been proposed to involve ******CD95/CD95 ligand****** ***interaction*** , we investigated the mechanism of caspase activation by daunorubicin , doxorubicin , etoposide , and mitomycin C.	parallel	1
2148	10216102	8772;355	FADD;CD95	The broad caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone prevented apoptosis and caspase-8 activation in response to CD95 and drug treatment , whereas a neutralizing CD95 decoy as well as a dominant-negative ***FADD*** construct selectively ***abrogated*** ***CD95*** , but not drug-induced effects .	negative	0
2149	10216102	9474;841	Asp;caspase-8	The broad caspase inhibitor ***benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone*** ***prevented*** apoptosis and ***caspase-8*** activation in response to CD95 and drug treatment , whereas a neutralizing CD95 decoy as well as a dominant-negative FADD construct selectively abrogated CD95 , but not drug-induced effects .	negative	0
2150	10216108	836;598	caspase-3;Bcl-Xl	This shift of balance of anti- and pro-apoptotic proteins was found to control ***caspase-3*** activity which , in turn , ***downregulated*** ***Bcl-Xl*** expression in PMN undergoing apoptosis .	negative	1
2151	10216139	7035;2152	TFPI;tissue factor	In contrast , mRNA expressions of ***tissue factor*** pathway ***inhibitor*** ( ***TFPI*** ) as well as thrombomodulin were almost undetectable in normal and partially resected livers .	negative	1
2152	10216198	2885;6464	GRB2;SHC	Insulin induces tyrosine phosphorylation of the insulin receptor and SHC , and ******SHC/GRB2****** ***association*** in cerebellum but not in forebrain cortex of rats .	parallel	0
2153	10216227	5015;4684	OTX2;NCAM	The mouse homeodomain protein ***OTX2*** ***regulates*** ***NCAM*** promoter activity .	target	1
2154	10216227	5015;4684	OTX2;NCAM	Taken together , our results argue for a ***regulation*** of ***NCAM*** expression by ***OTX2*** .	target	1
2155	10216229	5970;4790	RelA;p50	In electrophoretic mobility shift assays of kappaB-binding activity , we have found that the predominant activity in rat brain tissue , in primary neurons , and in neuronal cell lines has a mobility inconsistent with that of bona fide NF-kappaB ( ******RelA-p50****** ***heterodimer*** ) .	parallel	1
2156	10216283	335;57126	apo;cell surface receptor	Thus , cAMP-stimulated FC efflux involves probucol-sensitive processes distinct from ***apo*** A-I ***binding*** to its putative ***cell surface receptor*** .	parallel	1
2157	10216428	3553;3827	IL-1 beta;bradykinin	Taken together , our results suggest that ***IL-1 beta*** is able to ***potentiate*** the effect of ***bradykinin*** or tachykinin receptor agonists on the human isolated bronchus .	positive	0
2158	10216919	3240;335	Haptoglobin;apolipoprotein A-1	***Complexes*** of ***Haptoglobin*** with ***apolipoprotein A-1*** were isolated from follicular fluids by affinity chromatography with haemoglobin .	parallel	1
2159	10216942	1977;1981	eIF4E;eIF4G	Growth-regulated mRNAs are preferentially translated under conditions of accentuated ******eIF4E-eIF4G****** ***interaction*** .	parallel	1
2160	10217147	2185;4303	protein kinase B;AFX	Direct ***control*** of the Forkhead transcription factor ***AFX*** by ***protein kinase B*** .	target	0
2161	10217147	2185;4303	protein kinase B;AFX	Here we show that ***protein kinase B*** ***phosphorylates*** ***AFX*** , a human orthologue of daf-16 , both in vitro and in vivo .	target	1
2162	10217147	2185;4303	protein kinase B;AFX	Inhibition of endogenous PI ( 3 ) K and protein kinase B activity prevents ***protein kinase B-dependent*** ***phosphorylation*** of ***AFX*** and reveals residual protein kinase B-independent phosphorylation that requires Ras signalling towards the Ral GTPase .	target	1
2163	10217147	2185;4303	protein kinase B;AFX	In addition , ***phosphorylation*** of ***AFX*** by ***protein kinase B*** inhibits its transcriptional activity .	target	1
2164	10217220	3569;1051	IL-6;NF-IL6	Although ***IL-6*** mRNA levels ***correlated*** with NFkappaB and ***NF-IL6*** activation , tumor necrosis factor-alpha mRNA levels did not , in that they preceded transcription factor activation .	parallel	0
2165	10217220	3569;4790	IL-6;NFkappaB	Although ***IL-6*** mRNA levels ***correlated*** with ***NFkappaB*** and NF-IL6 activation , tumor necrosis factor-alpha mRNA levels did not , in that they preceded transcription factor activation .	parallel	0
2166	10217263	5594;3976	ERK;LIF	These results indicate that ***LIF*** mRNA levels can be ***regulated*** by ***ERK*** activation via stimulation of PKC in Schwann cells .	target	1
2167	10217264	1270;5368	CNTF;N/OFQ	***Regulation*** of ***N/OFQ*** expression by ***CNTF*** might point to a possible function of N/OFQ during development and after neural injury .	target	1
2168	10217264	1270;5368	CNTF;N/OFQ	***CNTF*** ***regulation*** of ***N/OFQ*** expression was sensitive to the kinase inhibitors H-7 and genistein but not to inhibition of protein synthesis .	target	1
2169	10217270	4908;627	neurotrophin-3;Brain-derived neurotrophic factor	Neither antibody crossreacts with neurotrophin homodimers other than Brain-derived neurotrophic factor , although reactivity was detected with ******Brain-derived neurotrophic factor/neurotrophin-3****** ***heterodimers*** .	parallel	1
2170	10217279	23523;84152	calcineurin inhibitor;DARPP-32	Cyclosporin A ( 5 microM ) , a ***calcineurin inhibitor*** , maximally ***increased*** the level of phosphorylated ***DARPP-32*** by 17 + / -2 - fold .	positive	0
2171	10217400	4609;3725	c-Myc;c-Jun	Moreover , ***c-Jun/c-Fos*** stimulation was ***inhibited*** by co-expression of ***c-Myc*** and Max .	negative	1
2172	10217400	4149;3725	Max;c-Jun	Moreover , ***c-Jun/c-Fos*** stimulation was ***inhibited*** by co-expression of c-Myc and ***Max*** .	negative	1
2173	10217420	10266;10203	RAMP2;CRLR	The ******RAMP2/CRLR****** ***complex*** is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells .	parallel	1
2174	10217420	10203;10266	calcitonin receptor-like receptor;receptor activity-modifying protein 2	Thus , the ******receptor activity-modifying protein 2/calcitonin receptor-like receptor****** ***complex*** apparently serves as a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells .	parallel	1
2175	10217702	3569;1401	interleukin-6;C-reactive protein	Evidence for a ***link*** between adipose tissue ***interleukin-6*** content and serum ***C-reactive protein*** concentrations in obese subjects .	parallel	0
2176	10217828	920;3700	CD4;gp120	HIV-1 attachment to host cells is generally considered to take place via high-affinity ***binding*** between ***CD4*** and ***gp120*** .	parallel	1
2177	10217828	3700;920	gp120;CD4	However , the ***binding*** of virion-associated ***gp120*** to cellular ***CD4*** is often weak , and most cell types that are permissive for HIV-1 infection express little CD4 .	parallel	1
2178	10218092	3456;3458	IFN-beta;IFN-gamma	However , ***IFN-beta*** ***inhibits*** ***IFN-gamma*** secretion of T cells , when they are stimulated by antigen presenting cells ( APC ) .	negative	1
2179	10218570	4193;4194	MDM2;MDMX	***MDM2*** ***interacts*** with ***MDMX*** through their RING finger domains .	parallel	1
2180	10218570	4194;7157	MDMX;p53	***MDMX*** is structurally related to MDM2 and also ***binds*** to ***p53*** .	parallel	1
2181	10218570	4194;4193	MDMX;MDM2	***Interaction*** of ***MDMX*** with ***MDM2*** through the C-terminal RING finger domains resulted in inhibiting degradation of MDM2 .	parallel	1
2182	10218570	4194;4193	MDMX;MDM2	These data indicate that ***MDMX*** functions as a ***regulator*** of ***MDM2*** .	target	1
2183	10218586	64375;10320	Eos;Ikaros	***Eos*** protein could ***interact*** with itself and ***Ikaros*** protein through its C-terminal portion in the yeast two hybrid assay .	parallel	1
2184	10218877	5443;1392	ACTH;corticotropin-releasing hormone	A direct ***ACTH*** ***modulation*** of brain electrophysiology or common factors ( e.g. the ***corticotropin-releasing hormone*** ) pacing both ACTH and EEG are suggested and may account for individual EEG differences .	target	0
2185	10218944	3717;3667	JAK2;IRS-1	Tyrosine-phosphorylated JAK2 resulting from GH stimulation was included in the amino-terminal IRS-1 fusion precipitates ; however , neither tyrosine phosphorylation of JAK2 nor treatment of cells with GH before extraction was necessary for the specific ******JAK2-IRS-1****** ***interaction*** to be detected .	parallel	1
2186	10218947	3490;3479	IGFBP-RP-1;IGF-I	IGFBP-related protein-1 ( ***IGFBP-RP-1*** ) , the product of the mac25 gene , ***binds*** ***IGF-I*** , IGF-II , and insulin .	parallel	1
2187	10218947	5741;3490	PTH;IGFBP-RP-1	In conclusion , ***PTH*** ***stimulates*** ***mac25/IGFBP-RP-1*** transcription in osteoblasts , an effect that could be relevant to the actions of PTH in bone .	positive	0
2188	10218952	1270;9021	CNTF;SOCS-3	***CNTF*** ***induced*** SOCS-3 mRNA and ***SOCS-3*** protein levels in an astrocyte cell line .	target	1
2189	10218952	1270;9021	CNTF;SOCS-3	In conclusion , ***SOCS-3*** mRNA is specifically ***induced*** by ***CNTF*** in regions of the hypothalamus that are both overlapping and distinct from that induced by leptin .	target	1
2190	10218952	9021;1270	SOCS-3;CNTF	***SOCS-3*** is a negative ***regulator*** of ***CNTF*** signal transduction , and inhibitors of SOCS-3 function may enhance endogenous CNTF signaling after neuronal injury or enhance the body weight-reducing effect of CNTF after peripheral administration .	negative	1
2191	10218952	1270;9021	CNTF;SOCS-3	Peripheral ***CNTF*** administration to ob/ob mice rapidly ***induced*** ***SOCS-3*** messenger RNA ( mRNA ) in hypothalamus , as determined by Northern blotting and quantitative RT-PCR , but had no effect on cytokine-inducible sequence ( CIS ) , SOCS-1 , or SOCS-2 mRNA .	target	1
2192	10218952	1270;9021	CNTF;SOCS-3	In situ hybridization histochemistry of hypothalamus from ob/ob mice and normal rats demonstrated that ***CNTF*** ***induced*** ***SOCS-3*** mRNA in the arcuate nucleus ( Arc ) .	target	1
2193	10218952	1270;8651	CNTF;SOCS-1	***CNTF*** also ***induced*** expression of CIS , ***SOCS-1*** , SOCS-2 , and SOCS-3 mRNA in the liver , and SOCS-2 and SOCS-3 mRNA in the kidney .	target	1
2194	10218952	1270;8835	CNTF;SOCS-2	***CNTF*** also ***induced*** expression of CIS , SOCS-1 , ***SOCS-2*** , and SOCS-3 mRNA in the liver , and SOCS-2 and SOCS-3 mRNA in the kidney .	target	1
2195	10218952	1270;9021	CNTF;SOCS-3	***CNTF*** also ***induced*** expression of CIS , SOCS-1 , SOCS-2 , and ***SOCS-3*** mRNA in the liver , and SOCS-2 and SOCS-3 mRNA in the kidney .	target	1
2196	10218968	5443;4159	alpha-MSH;MC3	***Desacetyl-alpha-MSH*** ***activated*** mouse MC1 , ***MC3*** , MC4 and MC5 receptors with EC50s = 0.13 , 0.96 , 0.53 , and 0.84 nM , and alpha-MSH activated these receptors with EC50s = 0.17 , 0.88 , 1.05 , and 1.34 nM , respectively .	positive	1
2197	10218974	3084;6462	heregulin-alpha;androgen-binding protein	Here we demonstrate that recombinant human ***heregulin-alpha*** ( Her-alpha ) and Her-beta ***stimulate*** transferrin and ***androgen-binding protein*** production by cultured rat Sertoli cells up to 2.5-fold .	positive	0
2198	10218974	3084;7018	heregulin-alpha;transferrin	Here we demonstrate that recombinant human ***heregulin-alpha*** ( Her-alpha ) and Her-beta ***stimulate*** ***transferrin*** and androgen-binding protein production by cultured rat Sertoli cells up to 2.5-fold .	positive	0
2199	10218975	796;1594	calcitonin;25-hydroxyvitamin D3 1alpha-hydroxylase	Positive and negative ***regulations*** of the renal ***25-hydroxyvitamin D3 1alpha-hydroxylase*** gene by parathyroid hormone , ***calcitonin*** , and 1alpha ,25 ( OH ) 2D3 in intact animals .	negative	1
2200	10218975	5741;1594	parathyroid hormone;25-hydroxyvitamin D3 1alpha-hydroxylase	Positive and negative ***regulations*** of the renal ***25-hydroxyvitamin D3 1alpha-hydroxylase*** gene by ***parathyroid hormone*** , calcitonin , and 1alpha ,25 ( OH ) 2D3 in intact animals .	negative	1
2201	10218975	796;1594	calcitonin;25-hydroxyvitamin D3 1alpha-hydroxylase	Reflecting the prime role of 1alpha ,25 ( OH ) 2D3 in calcium homeostasis , the activity of ***25-hydroxyvitamin D3 1alpha-hydroxylase*** , a key enzyme for 1alpha ,25 ( OH ) 2D3 biosynthesis , is tightly ***regulated*** by 1alpha ,25 ( OH ) 2D3 , PTH and ***calcitonin*** .	target	1
2202	10218975	5741;1594	PTH;25-hydroxyvitamin D3 1alpha-hydroxylase	Reflecting the prime role of 1alpha ,25 ( OH ) 2D3 in calcium homeostasis , the activity of ***25-hydroxyvitamin D3 1alpha-hydroxylase*** , a key enzyme for 1alpha ,25 ( OH ) 2D3 biosynthesis , is tightly ***regulated*** by 1alpha ,25 ( OH ) 2D3 , ***PTH*** and calcitonin .	target	1
2203	10218976	3484;3481	IGFBP-1;IGF-II	***IGF-II*** action is negatively ***regulated*** by ***IGFBP-1*** whose synthesis increases in the presence of glucocorticoids .	negative	1
2204	10218991	367;3488	Androgen receptor;insulin-like growth factor binding protein-5	***Androgen receptor*** ***up-regulates*** ***insulin-like growth factor binding protein-5*** ( IGFBP-5 ) expression in a human prostate cancer xenograft .	positive	1
2205	10218991	3488;3479	IGFBP-5;IGF-I	***IGFBP-5*** protein in tumor extracts ***bound*** 125I-labeled ***IGF-I*** in ligand blot assays and the amounts of IGFBP-5 measured by immunoblotting paralleled the levels of IGFBP-5 mRNA .	parallel	1
2206	10218993	3952;181	leptin;Agrp	These results suggest that in the fed state , ***Agrp*** is normally ***suppressed*** by ***leptin*** , and that release of this suppression during fasting leads to increased ingestive behavior .	negative	1
2207	10218994	2981;2984	uroguanylin;guanylyl cyclase-C	***uroguanylin*** is an endogenous peptide ***ligand*** for ***guanylyl cyclase-C*** , an apical membrane receptor predominantly located in the gastrointestinal epithelium .	parallel	1
2208	10219001	3574;5896	interleukin-7;recombination activating gene 1	***Activation*** of the ***recombination activating gene 1*** ( RAG-1 ) transcript in bone marrow of senescent C57BL/6 mice by recombinant ***interleukin-7*** .	positive	1
2209	10219001	3574;5896	interleukin-7;RAG-1	Recominbant ***interleukin-7*** ( rIL-7 ) is a potent proliferative stimulus for B cell progenitors and ***upregulates*** ***RAG-1*** expression in lymphocyte precursors .	positive	1
2210	10219078	10111;4361	Rad50;Mre11	Formation of the yeast ******Mre11-Rad50-Xrs2****** ***complex*** is correlated with DNA repair and telomere maintenance .	parallel	1
2211	10219078	4361;10111	Mre11;Rad50	Interestingly , deletion of these same 134 amino acids enhanced the ***interaction*** of ***Mre11*** with ***Rad50*** and Xrs2 , which is consistent with the notion that this region is specific for meiotic functions .	parallel	1
2212	10219080	4803;596	nerve growth factor;Bcl-2	***Activation*** of the ***Bcl-2*** promoter by ***nerve growth factor*** is mediated by the p42/p44 MAPK cascade .	positive	1
2213	10219080	4803;596	nerve growth factor;Bcl-2	We show for the first time that the ***Bcl-2*** promoter is ***activated*** by the neuronal survival factor ***nerve growth factor*** ( NGF ) and that this effect is dependent on a region of the promoter from -1472 to -1414 .	positive	1
2214	10219085	7702;5538	SBF;CLN1	Expression of G1cyclins ***CLN1*** and CLN2 is ***regulated*** by the transcription factor ***SBF*** ( composed of Swi4p and Swi6p ) and depends on the cyclin-dependent Cdc28 protein kinase and cyclin Cln3p .	target	1
2215	10219085	7702;1200	SBF;CLN2	Expression of G1cyclins CLN1 and ***CLN2*** is ***regulated*** by the transcription factor ***SBF*** ( composed of Swi4p and Swi6p ) and depends on the cyclin-dependent Cdc28 protein kinase and cyclin Cln3p .	target	1
2216	10219089	1191;2547	apoJ;Ku70	***Interactions*** of ***apoJ/XIP8*** or KUB3 with ***Ku70*** were confirmed by co-immunoprecipitation analyses in MCF-7 : WS8 breast cancer or IMR-90 normal lung fibroblast cells , respectively .	parallel	1
2217	10219089	91419;2547	KUB3;Ku70	***Interactions*** of apoJ/XIP8 or ***KUB3*** with ***Ku70*** were confirmed by co-immunoprecipitation analyses in MCF-7 : WS8 breast cancer or IMR-90 normal lung fibroblast cells , respectively .	parallel	1
2218	10219089	1191;2547	apoJ;Ku70	The ***interaction*** of ***apoJ/XIP8*** with ***Ku70*** was confirmed by far-western analyses .	parallel	1
2219	10219249	3586;3569	IL-10;IL-6	Exogenous ***IL-10*** and IL-4 ***down-regulate*** ***IL-6*** production by SLE-derived PBMC .	negative	1
2220	10219249	3565;3569	IL-4;IL-6	Exogenous IL-10 and ***IL-4*** ***down-regulate*** ***IL-6*** production by SLE-derived PBMC .	negative	1
2221	10219249	3586;3569	IL-10;IL-6	***IL-6*** production by normal monocytes can be ***inhibited*** by ***IL-10*** , and it has been suggested that SLE monocytes are refractory to this negative signal .	negative	1
2222	10219249	3565;3569	IL-4;IL-6	We found that ( 1 ) exogenous rIL-10 and rIL-4 mediated reduction of constitutive and lectin-induced IL-6 in monocytes of SLE patients as effectively as that of controls ; ( 2 ) IL-6 mRNA decay was significantly delayed in SLE with active disease ( P < 0.001 ) ; ( 3 ) adding rIL-10 or neutralizing endogenous IL-1 beta and TNF-alpha down-regulated IL-6 mainly by destabilizing IL-6 transcripts , whereas exogenous ***IL-4*** and TGF beta 1 ***down-regulated*** ***IL-6*** transcriptionally ; ( 4 ) time kinetics and levels of IL-10 were lower than those of IL-6 and IL-1 beta .	negative	1
2223	10219249	7040;3569	TGF beta 1;IL-6	We found that ( 1 ) exogenous rIL-10 and rIL-4 mediated reduction of constitutive and lectin-induced IL-6 in monocytes of SLE patients as effectively as that of controls ; ( 2 ) IL-6 mRNA decay was significantly delayed in SLE with active disease ( P < 0.001 ) ; ( 3 ) adding rIL-10 or neutralizing endogenous IL-1 beta and TNF-alpha down-regulated IL-6 mainly by destabilizing IL-6 transcripts , whereas exogenous IL-4 and ***TGF beta 1*** ***down-regulated*** ***IL-6*** transcriptionally ; ( 4 ) time kinetics and levels of IL-10 were lower than those of IL-6 and IL-1 beta .	negative	1
2224	10219631	7430;1739	ezrin;SAP 97	Immunoprecipitation confirms a direct ***binding*** of ***SAP 97*** and ***ezrin*** .	parallel	1
2225	10219659	1991;2006	HNE;elastin	METHODS : ***elastin*** ***degradation*** by ***HNE*** was monitored spectrophotometrically with elastin-congo red .	negative	1
2226	10219759	958;959	CD40;CD40L	The ***interaction*** between ***CD40*** and ***CD40L*** plays important roles in immune responses .	parallel	1
2227	10219841	3458;3383	IFN-gamma;ICAM-1	These results indicate that ***IFN-gamma*** and TNF-alpha ***induce*** the expression of ***ICAM-1*** on parenchymal hepatocytes and that the LFA-1-ICAM-1 pathway plays an important role in the interaction between hepatocytes and neutrophils or lymphocytes .	target	1
2228	10219841	7124;3383	TNF-alpha;ICAM-1	These results indicate that IFN-gamma and ***TNF-alpha*** ***induce*** the expression of ***ICAM-1*** on parenchymal hepatocytes and that the LFA-1-ICAM-1 pathway plays an important role in the interaction between hepatocytes and neutrophils or lymphocytes .	target	1
2229	10219967	2908;1576	glucocorticoid receptor;CYP3A4	These results highlight differences in the molecular mechanisms of induction of CYP3A4 by the xenobiotics studied and indicate that the ***glucocorticoid receptor*** is involved in the ***induction*** of the ***CYP3A4*** gene by some , but not all , CYP3A4 inducers .	target	1
2230	10220325	7134;7138	TnC;TnT	TnC ( E53A/E54A ) and ***TnC*** ( E85A/D86A ) ***interacted*** weakly with ***TnT*** , as judged by native gel electrophoresis .	parallel	1
2231	10220325	7134;7138	TnC;TnT	***TnC*** ( E60A/E61A ) ***interacted*** normally with ***TnT*** .	parallel	1
2232	10220372	9519;2959	TRF2;TFIIB	Like TRF1 and TBP , ***TRF2*** ***binds*** transcription factor IIA ( TFIIA ) and ***TFIIB*** and appears to be part of a larger protein complex .	parallel	1
2233	10220378	5923;5599	Ras-GRF1;JNK1	Activation of the Rac pathway in the cell was further evidenced by synergistic ***activation*** of the stress kinase ***JNK1*** by ***Ras-GRF1*** and Gbeta gamma , which is sensitive to inhibitory action of dominant-negative Rac1 ( 17N ) .	positive	1
2234	10220378	5923;5879	Ras-GRF1;Rac1	In addition , ***association*** of ***Ras-GRF1*** with ***Rac1*** ( 17N ) was demonstrated by coimmunoprecipitation .	parallel	0
2235	10220378	8801;9181	Gbeta;GEF	Evidence for the involvement of tyrosine kinase ( s ) in ***Gbeta*** gamma-mediated ***induction*** of Rac1-specific ***GEF*** activity was provided by the use of specific inhibitors .	target	1
2236	10220381	4088;3725	Smad3;AP-1	Here , we report that ***Smad3*** and Smad4 can physically ***interact*** with ***AP-1*** family members .	parallel	1
2237	10220381	4089;3725	Smad4;AP-1	Here , we report that Smad3 and ***Smad4*** can physically ***interact*** with ***AP-1*** family members .	parallel	1
2238	10220381	4088;3725	Smad3;Jun	In vitro binding studies demonstrate that both ***Smad3*** and Smad4 ***bind*** all three ***Jun*** family members : JunB , cJun , and JunD .	parallel	1
2239	10220381	4089;3725	Smad4;Jun	In vitro binding studies demonstrate that both Smad3 and ***Smad4*** ***bind*** all three ***Jun*** family members : JunB , cJun , and JunD .	parallel	1
2240	10220405	672;5931	BRCA1;RbAp46	Here we report that ***BRCA1*** ***interacts*** in vivo and in vitro with the Rb-binding proteins , ***RbAp46*** and RbAp48 , as well as with Rb .	parallel	1
2241	10220405	672;5928	BRCA1;RbAp48	Here we report that ***BRCA1*** ***interacts*** in vivo and in vitro with the Rb-binding proteins , RbAp46 and ***RbAp48*** , as well as with Rb .	parallel	1
2242	10220796	947;7157	CD34;p53	***CD34*** expression also ***correlated*** well with ***p53*** accumulation ( r = 0.859 , p = 0.000002 ) .	parallel	0
2243	10221260	1026;596	cip1;bcl-2	RESULTS : The expression of p21 ( ***waf1/cip1*** ) protein was significantly ***associated*** with high Gleason score ( P = 0.001 ) , DNA aneuploidy ( P = 0.013 ) , high S-phase fraction ( P = 0.019 ) , and expression of Ki-67 ( P = 0.021 ) and ***bcl-2*** ( P = 0.001 ) as well as cyclin A ( P = 0.035 ) and D proteins ( P < 0.001 ) .	parallel	0
2244	10221543	1906;3569	endothelin-1;interleukin-6	We previously reported that ***endothelin-1*** ***induces*** synthesis of ***interleukin-6*** ( IL-6 ) via activation of protein kinase C in osteoblast-like MC3T3-E1 cells .	target	1
2245	10221543	1906;5706	endothelin-1;p44	***endothelin-1*** ***stimulated*** ***p42/p44*** MAP kinase activation in a dose-dependent manner in the range between 0.1 nmol/L and 0.1 micromol/L .	positive	0
2246	10221592	133;5443	PAMP;ACTH	Here we report that basal , but not stimulated , ***ACTH*** secretion from cultured rat pituitary cells is also ***inhibited*** by ***PAMP*** .	negative	1
2247	10221598	5618;7409	PRLR;Vav	These observations suggest that PRL signaling reflects the transient formation of a ******PRLR-ZAP-70-Vav****** ***complex*** and its immunomodulatory actions involve diverse interactions that affect TCR expression and signaling mechanisms .	parallel	1
2248	10221598	5618;7535	PRLR;ZAP-70	These observations suggest that PRL signaling reflects the transient formation of a ******PRLR-ZAP-70-Vav****** ***complex*** and its immunomodulatory actions involve diverse interactions that affect TCR expression and signaling mechanisms .	parallel	1
2249	10221598	7409;7535	Vav;ZAP-70	These observations suggest that PRL signaling reflects the transient formation of a ******PRLR-ZAP-70-Vav****** ***complex*** and its immunomodulatory actions involve diverse interactions that affect TCR expression and signaling mechanisms .	parallel	1
2250	10221646	3586;942	IL-10;CD86	In BALB.B macrophages , T. gondii-induced ***IL-10*** ***down-regulates*** surface expression of ***CD86*** , thus indicating an interference of parasite-dependent cytokine release and modulation of CD86 .	negative	1
2251	10221670	4803;4099	Nerve growth factor;myelin-associated glycoprotein	***Nerve growth factor*** ***modulates*** ***myelin-associated glycoprotein*** binding to sensory neurons .	target	0
2252	10221670	4803;4099	Nerve growth factor;MAG	***Nerve growth factor*** ( NGF ) ***upregulated*** expression of the ***MAG*** binding molecule in a dose dependent manner .	positive	1
2253	10221670	4803;4099	NGF;MAG	Schwann cells co-cultured with sensory neurons in serum-free medium stimulated maximal expression of the ***MAG*** binding molecule , which was ***decreased*** by addition of ***anti-NGF*** to the co-cultures .	negative	0
2254	10221778	3553;10468	IL-1beta;follistatin	Production of ***follistatin*** by HepG2 cells was stimulated by activin A , but was ***inhibited*** by both ***IL-1beta*** and IL-6 , indicating a complex regulatory loop is operable to modulate the effects of activin A during inflammation .	negative	1
2255	10221780	5617;3717	Prolactin;Jak2	***Jak2*** and Stat1 phosphorylation were ***induced*** by ***Prolactin*** within 10 min and Stat5 within 30 min .	target	1
2256	10221780	5617;6772	Prolactin;Stat1	Jak2 and ***Stat1*** phosphorylation were ***induced*** by ***Prolactin*** within 10 min and Stat5 within 30 min .	target	1
2257	10221781	7124;7018	tumor necrosis factor alpha;transferrin	In vitro ***regulation*** of rat Sertoli cell ***transferrin*** expression by ***tumor necrosis factor alpha*** and retinoic acid .	target	1
2258	10221781	7124;7018	tumor necrosis factor alpha;transferrin	In the present study , we examined the in vitro ***regulation*** of 20-day-old rat Sertoli cell ***transferrin*** expression by ***tumor necrosis factor alpha*** ( TNFalpha ) , a paracrine factor produced by germ cells .	target	1
2259	10222053	5777;933	SHP-1;CD22	In B lymphocytes , the down-regulatory phosphatase ***SHP-1*** ***associates*** with ***CD22*** and CD32b ( also known as FcgammaRIIB ) and acts as a critical negative regulator of B-cell receptor signaling .	parallel	0
2260	10222053	5777;2213	SHP-1;CD32b	In B lymphocytes , the down-regulatory phosphatase ***SHP-1*** ***associates*** with CD22 and ***CD32b*** ( also known as FcgammaRIIB ) and acts as a critical negative regulator of B-cell receptor signaling .	parallel	0
2261	10222064	3565;960	IL-4;CD44	***IL-4*** ***decreased*** ***CD44-HA*** binding on monocytes initially treated with TNFalpha .	negative	0
2262	10222064	3565;960	IL-4;CD44	In contrast , ***IL-4*** treatment of monocytes ***inhibited*** ***CD44-HA*** binding and reversed the 5 - to 10-kDa decrease in monocyte CD44 Mr.	negative	1
2263	10222136	998;6383	cdc42Hs;Syndecan-2	These results provide a ***link*** between ***Syndecan-2*** , actin cytoskeleton , and ***cdc42Hs*** .	parallel	0
2264	10222137	4193;7157	MDM2;p53	Using a model cell line conditionally expressing MDM2 , the murine analogue of HDM2 , we present evidence indicating that leptomycin B abrogates MDM2 's role in p53 degradation and that the accumulation of ***p53*** in distinct nuclear bodies is ***mediated*** by ***MDM2*** .	target	0
2265	10222149	4485;5747	MSP;FAK	***MSP*** also ***affected*** focal adhesion kinase ( ***FAK*** ) which is important for some types of cell adhesion and motility .	target	0
2266	10222227	1906;3565	endothelin-1;interleukin-4	In this study , we investigated gastric mucosal inflammatory responses during Helicobacter pylori lipopolysaccharide-induced gastritis by analyzing the ***interplay*** between mucosal expression of ***endothelin-1*** ( ET-1 ) , ***interleukin-4*** ( IL-4 ) and tumor necrosis factor-alpha ( TNF-alpha ) .	parallel	1
2267	10222245	3952;3060	leptin;orexin	***orexin*** A concentration in the lateral hypothalamus was significantly ***decreased*** by the ***leptin*** treatment ( -68 % ; p < 0.01 ) .	negative	0
2268	10222798	6387;7852	SDF-1;CXCR4	SDF-1 , a cytokine belonging to the chemokine family has an inhibitory activity against the HIV-1 infection , because ***SDF-1*** Is the physiological ***ligand*** for ***CXCR4*** , the entry coreceptor for T tropic HIV-1 virus .	parallel	1
2269	10223183	3827;2822	bradykinin;PLD	***bradykinin*** ***activated*** ***PLD*** acutely but transiently .	positive	1
2270	10223185	3082;4233	HGF;c-met	These results suggest the possibility of ***cross-talk*** between ******HGF/c-met****** and EGF/EGFR signaling pathways , and the involvement of JNK1 induction in HGF-mediated apoptotic cell death .	parallel	0
2271	10223185	3082;900	HGF;cyclin G1	***HGF*** treatment ***increased*** cyclin A , ***cyclin G1*** and nuclear transcriptional factor ( NFkappaB ) protein expression .	positive	0
2272	10223185	3082;4790	HGF;NFkappaB	***HGF*** treatment ***increased*** cyclin A , cyclin G1 and nuclear transcriptional factor ( ***NFkappaB*** ) protein expression .	positive	0
2273	10223208	51176;1499	LEF-1;beta-catenin	Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated ******beta-catenin-LEF-1****** transcription ***complex*** in mouse colonic epithelial cells contrasting in Apc .	parallel	1
2274	10223208	324;5743	Apc;PGHS-2	It has been suggested that ***Apc*** mutations are ***linked*** mechanistically to increased ***PGHS-2*** expression by elevated nuclear accumulation of beta-catenin-Tcf-LEF transcription complex .	parallel	0
2275	10223208	51176;1499	LEF-1;beta-catenin	Our data indicate that the differential induction of ******beta-catenin-LEF-1****** ***complex*** correlates closely with differential expression of PGHS-2 .	parallel	1
2276	10223294	7056;5624	thrombomodulin;protein C	Probing the ***activation*** of ***protein C*** by the ***thrombin-thrombomodulin*** complex using structural analysis , site-directed mutagenesis , and computer modeling .	positive	1
2277	10223354	7124;3384	Tumor necrosis factor (TNF)-alpha;intercellular adhesion molecule (ICAM)-2	***Tumor necrosis factor (TNF)-alpha*** and interleukin ( IL ) -1 beta ***down-regulate*** ***intercellular adhesion molecule (ICAM)-2*** expression on the endothelium .	negative	1
2278	10223354	3384;3689	ICAM-2;Mac-1	***ICAM-2*** , a constitutively expressed endothelial ***ligand*** for beta2 integrins LFA-1 and ***Mac-1*** , is involved in leukocyte adhesion to resting endothelium and in transmigration in vitro , however its role in inflammation is unclear .	parallel	1
2279	10223618	958;355	CD40;Fas	***CD40*** stimulation ***enhanced*** ***Fas*** expression on HTC/C3 cells .	positive	0
2280	10223618	958;596	CD40;Bcl-2	***CD40*** stimulation ***enhanced*** ***Bcl-2*** expression , and antisense oligonucleotide against Bcl-2 canceled the inhibition of HTC/C3 cell growth caused by CD40 stimulation .	positive	0
2281	10223633	4133;4137	MAP2b;Tau	Collectively , these results indicate that ***MAP2b*** could ***impair*** the ability of MAP2c and ***Tau*** to redistribute F-actin in Sf9 cells , thereby decreasing their capacity to induce process formation .	negative	0
2282	10223633	4133;4137	MAP2b;Tau	***MAP2b*** ***impairs*** ***Tau*** ability to induce process outgrowth .	negative	0
2283	10223633	4137;4133	Tau;MAP2c	***Tau*** ***affects*** ***MAP2c*** capacity to induce the formation of multiple processes .	target	0
2284	10223719	9241;2353	Noggin;Fos	***Noggin*** ***upregulates*** ***Fos*** expression by a calcium-mediated pathway in amphibian embryos .	positive	1
2285	10224040	317;4790	CED-4;NF-kappaB	Human CARD4 protein is a novel ***CED-4/Apaf*** -1 cell death family member that ***activates*** ***NF-kappaB*** .	positive	1
2286	10224040	10392;8767	CARD4;RICK	***CARD4*** ***interacted*** with the serine-threonine kinase ***RICK*** and potently induced NF-kappaB activity through TRAF-6 and NIK signaling molecules .	parallel	1
2287	10224040	10392;4790	CARD4;NF-kappaB	***CARD4*** interacted with the serine-threonine kinase RICK and potently ***induced*** ***NF-kappaB*** activity through TRAF-6 and NIK signaling molecules .	target	1
2288	10224043	3298;5524	HSF2;PP2A	In addition , overexpression of ***HSF2*** ***stimulates*** ***PP2A*** activity in cells , indicating the relevance of HSF2 as a regulator of PP2A in vivo .	positive	0
2289	10224044	4088;7421	Smad3;vitamin D receptor	Recently , we found that ***Smad3*** , a downstream component of the TGF-beta signaling pathway , ***potentiates*** ligand-induced transactivation of ***vitamin D receptor*** ( VDR ) as a coactivator of VDR ( Yanagisawa , J. , Yanagi , Y. , Masuhiro , Y. , Suzawa , M. , Watanabe , M. , Kashiwagi , K. , Toriyabe , T. , Kawabata , M. , Miyazono , K. , and Kato , S. ( 1999 ) Science 283 , 1317-1321 ) .	positive	0
2290	10224044	4091;7040	Smad6;TGF-beta	Here , we investigated the roles of inhibitory Smads , ***Smad6*** and Smad7 , which are negative ***regulators*** of the ***TGF-beta/bone*** morphogenetic protein signaling pathway , on the Smad3-mediated potentiation of VDR function .	negative	1
2291	10224044	4092;7040	Smad7;TGF-beta	Here , we investigated the roles of inhibitory Smads , Smad6 and ***Smad7*** , which are negative ***regulators*** of the ***TGF-beta/bone*** morphogenetic protein signaling pathway , on the Smad3-mediated potentiation of VDR function .	negative	1
2292	10224044	4092;4088	Smad7;Smad3	Interaction studies in vivo and in vitro showed that ***Smad7*** ***inhibited*** the formation of the ***VDR-Smad3*** complex , whereas Smad6 had no effect .	negative	1
2293	10224044	4092;7421	Smad7;VDR	Interaction studies in vivo and in vitro showed that ***Smad7*** ***inhibited*** the formation of the ***VDR-Smad3*** complex , whereas Smad6 had no effect .	negative	1
2294	10224044	7421;4088	VDR;Smad3	Interaction studies in vivo and in vitro showed that Smad7 inhibited the formation of the ******VDR-Smad3****** ***complex*** , whereas Smad6 had no effect .	parallel	1
2295	10224053	7528;3949	YY1;LDL receptor	The inhibition is independent of ***YY1*** ***binding*** directly to the ***LDL receptor*** promoter , and we show that the same region of YY1 that interacts in solution with Sp1 also interacts with SREBP .	parallel	1
2296	10224058	5340;4318	plasmin;matrix metalloproteinase-9	***Activation*** of ***matrix metalloproteinase-9*** ( MMP-9 ) via a converging ***plasmin/stromelysin*** -1 cascade enhances tumor cell invasion .	positive	1
2297	10224067	7040;5599	TGF-beta;JNK1	Although SEK and MKK7 acted downstream of TAK1 , only a kinase-defective SEK mutant blocked ***TGF-beta-induced*** ***activation*** of ***JNK1*** , indicating that the TGF-beta signal is relayed solely through SEK , but not MKK7 , in vivo .	positive	1
2298	10224067	7040;5599	TGF-beta;JNK1	The ***activation*** of ***JNK1*** by ***TGF-beta*** was abrogated by a kinase-defective HPK1 mutant but not by a kinase-defective mutant of kinase homologous to Ste20/Sps1 .	positive	1
2299	10224067	11184;5599	HPK1;JNK1	The activation of ***JNK1*** by TGF-beta was ***abrogated*** by a kinase-defective ***HPK1*** mutant but not by a kinase-defective mutant of kinase homologous to Ste20/Sps1 .	positive	0
2300	10224067	7040;5599	TGF-beta;JNK1	This result indicates that HPK1 is specifically required for ***TGF-beta-induced*** ***activation*** of ***JNK1*** .	positive	1
2301	10224067	6885;5599	TGF-beta-activated kinase 1;JNK1	We also found that TGF-beta-induced ***JNK1*** activation was ***blocked*** by a kinase-defective mutant of ***TGF-beta-activated kinase 1*** ( TAK1 ) .	positive	0
2302	10224067	6885;11184	TAK1;HPK1	In addition , ***interaction*** between ***HPK1*** and ***TAK1*** was observed in transient transfection assays , and this interaction was enhanced by TGF-beta treatment .	parallel	1
2303	10224067	5609;5599	MKK7;JNK1	Both stress-activated protein kinase/extracellular signal-regulated kinase kinase ( SEK ) and mitogen-activated protein kinase kinase 7 ( ***MKK7*** ) are immediate upstream ***activators*** of ***JNK1*** .	positive	1
2304	10224076	6294;998	glutathione S-transferase fusion protein;cdc42	A p21-binding domain ***glutathione S-transferase fusion protein*** specifically ***binds*** Rac and ***cdc42*** in their GTP-bound forms both in vitro and in cell samples .	parallel	1
2305	10224081	8106;10196	Poly(A)-binding protein II;PRMT3	***Poly(A)-binding protein II*** and deletion mutants expressed in Escherichia coli were in vitro ***substrates*** for two mammalian protein arginine methyltransferases , PRMT1 and ***PRMT3*** , with S-adenosyl-L-methionine as the methyl group donor .	parallel	1
2306	10224090	578;598	Bak;Bcl-xL	***Bak*** BH3 peptides ***antagonize*** ***Bcl-xL*** function and induce apoptosis through cytochrome c-independent activation of caspases .	negative	1
2307	10224093	10391;7414	ClipinC;vinculin	Furthermore , ***ClipinC*** was ***associated*** with ***vinculin*** , which is a major component of focal contacts .	parallel	0
2308	10224094	836;5747	caspase-3;FAK	DCVC treatment activated ***caspase-3*** which was ***associated*** with cleavage of ***FAK*** .	parallel	0
2309	10224109	4790;3576	NF-kappaB;IL-8	In 16HBE human bronchial epithelial cells , ***IL-8*** expression is ***regulated*** predominantly by ***NF-kappaB*** , and PG490 but not cyclosporin A can completely inhibit expression of IL-8 .	target	1
2310	10224110	7124;4790	TNF-alpha;NF-kappaB	PG490 potently inhibited ***TNF-alpha-induced*** ***activation*** of ***NF-kappaB*** .	positive	1
2311	10224110	7124;329	TNF-alpha;c-IAP1	PG490 also blocked ***TNF-alpha-mediated*** ***induction*** of c-IAP2 ( hiap-1 ) and ***c-IAP1*** ( hiap-2 ) , members of the inhibitor of apoptosis ( IAP ) family .	target	1
2312	10224110	7124;330	TNF-alpha;c-IAP2	PG490 also blocked ***TNF-alpha-mediated*** ***induction*** of ***c-IAP2*** ( hiap-1 ) and c-IAP1 ( hiap-2 ) , members of the inhibitor of apoptosis ( IAP ) family .	target	1
2313	10224110	7124;4790	TNF-alpha;NF-kappaB	Our identification of a compound that blocks ***TNF-alpha-induced*** ***activation*** of ***NF-kappaB*** may enhance the cytotoxicity of TNF-alpha on tumors in vivo and limit its proinflammatory effects .	positive	1
2314	10224114	7066;3717	Thrombopoietin;JAK2	***Thrombopoietin*** signal transduction ***requires*** functional ***JAK2*** , not TYK2 .	target	0
2315	10224114	4352;3717	proto-oncogene c-mpl;JAK2	Upon binding to its receptor , the product of the ***proto-oncogene c-mpl*** , Thrombopoietin ( TPO ) ***activates*** both ***JAK2*** and TYK2 in multiple cell lines as well as megakaryocytes and platelets .	positive	1
2316	10224120	10728;3320	p23;hsp90	Ligand dependence was reconstituted in the presence of molybdate , a transition metal ion known to stabilize the ***interaction*** between the molecular chaperone ***hsp90*** and ***p23*** .	parallel	1
2317	10224122	6385;2247	syndecan-4;bFGF	Further , heparan sulfate proteoglycans and , specifically , ***syndecan-4*** were implicated as the ***modulator*** of ***bFGF*** binding and activity .	target	0
2318	10224125	4301;5906	AF6;Rap1A	Notably , among the Ras-related proteins ***AF6*** ***binds*** most tightly to ***Rap1A*** which could imply a role of Rap1A in AF6 regulation .	parallel	1
2319	10224129	7057;7040	thrombospondin-1;TGF-beta	The mechanism of ***TGF-beta*** ***activation*** by ***thrombospondin-1*** appears to be conserved among TGF-beta isoforms as latent TGF-beta2 can also be activated by thrombospondin-1 or KRFK peptides in a manner that is sensitive to inhibition by LSKL peptides .	positive	1
2320	10224129	7040;7057	latency-associated peptide;thrombospondin-1	We now report that the ***latency-associated peptide*** ( LAP ) of the latent TGF-beta complex also ***interacts*** with ***thrombospondin-1*** as part of a biologically active complex .	parallel	1
2321	10224129	7040;7057	LAP;thrombospondin-1	The ***interactions*** of ***LAP*** with ***thrombospondin-1*** through the LSKL and KRFK sequences are important for thrombospondin-mediated activation of latent TGF-beta since LSKL peptides can competitively inhibit latent TGF-beta activation by thrombospondin or KRFK-containing peptides .	parallel	1
2322	10224129	7040;7040	TGF-beta;LAP	In addition , the association of LAP with thrombospondin-1 may function to prevent the re-formation of an inactive ******LAP.TGF-beta****** ***complex*** since thrombospondin-bound LAP no longer confers latency on active TGF-beta .	parallel	1
2323	10224129	7040;7057	LAP;thrombospondin-1	In addition , the ***association*** of ***LAP*** with ***thrombospondin-1*** may function to prevent the re-formation of an inactive LAP.TGF-beta complex since thrombospondin-bound LAP no longer confers latency on active TGF-beta .	parallel	0
2324	10224131	5106;5468	PCK2;PPARgamma	The human and rat ***PCK2*** elements ***bound*** ***PPARgamma/RXR*** with the same affinities .	parallel	1
2325	10224135	4091;4086	Smad6;Smad1	Moreover , we confirmed that the ectopic expressions of ***Smad6*** and Smad7 ***inhibited*** the hBMP-2-induced ***Smad1/Smad5*** phosphorylation .	negative	1
2326	10224135	4091;4090	Smad6;Smad5	Moreover , we confirmed that the ectopic expressions of ***Smad6*** and Smad7 ***inhibited*** the hBMP-2-induced ***Smad1/Smad5*** phosphorylation .	negative	1
2327	10224135	4092;4086	Smad7;Smad1	Moreover , we confirmed that the ectopic expressions of Smad6 and ***Smad7*** ***inhibited*** the hBMP-2-induced ***Smad1/Smad5*** phosphorylation .	negative	1
2328	10224135	4092;4090	Smad7;Smad5	Moreover , we confirmed that the ectopic expressions of Smad6 and ***Smad7*** ***inhibited*** the hBMP-2-induced ***Smad1/Smad5*** phosphorylation .	negative	1
2329	10224135	4092;4087	Smad7;Smad2	Moreover , we found that the ectopic expression of ***Smad7*** , but not Smad6 , ***inhibited*** the activin A-induced ***Smad2*** phosphorylation in HS-72 cells .	negative	1
2330	10224145	4086;3224	Smad1;Hoxc-8	Our findings suggest that ***Smad1*** ***interaction*** with ***Hoxc-8*** dislodges Hoxc-8 from its DNA binding element , resulting in the induction of gene expression .	parallel	1
2331	10224145	4086;4089	Smad1;Smad4	Upon phosphorylation by the BMP receptors , ***Smad1*** ***interacts*** with ***Smad4*** and translocates into the nucleus where the complex recruits DNA-binding protein ( s ) to activate specific gene transcription .	parallel	1
2332	10224145	4086;3224	Smad1;Hoxc-8	Using a yeast two-hybrid approach , we found that ***Smad1*** ***interacts*** with ***Hoxc-8*** , a homeodomain transcription factor .	parallel	1
2333	10224145	4086;3224	Smad1;Hoxc-8	The ***interaction*** between ***Smad1*** and ***Hoxc-8*** was confirmed by a " pull-down " assay and a co-immunoprecipitation experiment in COS-1 cells .	parallel	1
2334	10224145	3224;6696	Hoxc-8;osteopontin	Interestingly , purified Smad1 inhibited ***Hoxc-8*** ***binding*** to the ***osteopontin*** Hoxc-8 site in a concentration-dependent manner .	parallel	1
2335	10224145	4086;3224	Smad1;Hoxc-8	Interestingly , purified ***Smad1*** ***inhibited*** ***Hoxc-8*** binding to the osteopontin Hoxc-8 site in a concentration-dependent manner .	negative	1
2336	10224160	4043;5054	RAP;PAI-1	Addition of ***RAP*** completely ***blocked*** the VLDL-activated ***PAI-1*** transcription .	negative	0
2337	10224227	355;3297	Fas;HSF1	Activation of ***Fas*** ***inhibits*** heat-induced activation of ***HSF1*** and up-regulation of hsp70 .	negative	1
2338	10224227	355;3308	Fas;hsp70	Activation of ***Fas*** ***inhibits*** heat-induced activation of HSF1 and up-regulation of ***hsp70*** .	negative	1
2339	10224244	80149;6908	Reg1;TBP	***Suppression*** of the ***TBP*** mutant by our ***Reg1*** and SNF4 mutations appears unrelated to glucose repression , since these mutations do not alleviate repression of SUC2 , and glucose levels have little effect on INO1 transcription .	negative	1
2340	10224276	3458;3620	IFN-gamma;IDO	***IDO*** was ***induced*** in macrophages by a synergistic combination of the T cell-derived signals ***IFN-gamma*** and CD40-ligand .	target	1
2341	10224278	9402;27040	Grf40;linker for activation of T cells	Incidentally , ***Grf40*** ***binds*** to ***linker for activation of T cells*** ( LAT ) possibly via its SH2 domain .	parallel	1
2342	10224288	998;207	Cdc42;Rac	However , expression of an effector loop mutant of Cdc42Hs ( Cdc42HsC40 ) unable to bind PAK and other CRIB ( for ******Cdc42/Rac****** interacting ***binding*** ) - containing target proteins resulted in abrogation of both S. typhimurium-induced nuclear and cytoskeletal responses .	parallel	1
2343	10224350	1232;6356	CCR3;eotaxin	METHODS : We have examined phenotypic changes as CD34 + cells develop to the eosinophil lineage in vitro , and have evaluated BM eosinophils from asthmatic and control subjects for expression of the ***eotaxin*** ***receptor*** , ***CCR3*** .	parallel	1
2344	10224454	7040;3596	TGF-beta;IL-13	The production of IL-4 and ***IL-13*** by naive T cells is differentially ***regulated*** by ***TGF-beta*** and IL-12 .	target	1
2345	10224454	7040;3565	TGF-beta;IL-4	The production of ***IL-4*** and IL-13 by naive T cells is differentially ***regulated*** by ***TGF-beta*** and IL-12 .	target	1
2346	10224454	7293;3596	OX40;IL-13	Engagement of ***OX40*** on activated naive T cells ***increases*** their expression of IL-4 and ***IL-13*** , suppresses that of IFN-gamma and promotes their development into Th2-like effectors .	positive	0
2347	10224454	7293;3565	OX40;IL-4	Engagement of ***OX40*** on activated naive T cells ***increases*** their expression of ***IL-4*** and IL-13 , suppresses that of IFN-gamma and promotes their development into Th2-like effectors .	positive	0
2348	10224467	3565;3558	IL-4;IL-2	***IL-4*** ***inhibits*** human CD8 T cell expression of the common ***IL-2*** receptor gamma chain .	negative	1
2349	10224501	7040;5328	TGF-beta;uPA	***TGF-beta*** appeared to ***induce*** also membrane-bound ***uPA*** activity and the release of active plasminogen activator inhibitor-1 , indicating that TGF-beta has the potential to regulate plasminogen activation at the RPE cell surface .	target	1
2350	10224501	7040;5502	TGF-beta;inhibitor-1	***TGF-beta*** appeared to ***induce*** also membrane-bound uPA activity and the release of active plasminogen activator ***inhibitor-1*** , indicating that TGF-beta has the potential to regulate plasminogen activation at the RPE cell surface .	target	1
2351	10224665	3984;1072	LIMK1;cofilin	***LIMK1*** ***phosphorylates*** ***cofilin*** , an actin depolymerisation factor , which is then unable to bind and depolymerise F-actin .	target	1
2352	10225366	3952;1392	Leptin;CRH	Using primary cultures of neonatal ( 5 - to 6-day-old ) rat hypothalamic cells , we confirmed that ***Leptin*** ( 0.1-10 nM ) ***stimulates*** ***CRH*** secretion .	positive	0
2353	10225429	1268;6548	CB1;NHE-1	Cannabinoid receptor ***CB1*** ***activates*** the Na + / H + exchanger ***NHE-1*** isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways .	positive	1
2354	10225429	1268;5706	CB1;p44	These results suggest that ***CB1*** ***stimulates*** NHE-1 by G ( i/o ) - mediated activation of ***p42/p44*** MAP kinase and highlight a cellular physiological process targeted by CB1 .	positive	0
2355	10225429	1268;6548	CB1;NHE-1	These results suggest that ***CB1*** ***stimulates*** ***NHE-1*** by G ( i/o ) - mediated activation of p42/p44 MAP kinase and highlight a cellular physiological process targeted by CB1 .	positive	0
2356	10225447	356;355	FasL;Fas	Fas and ***Fas*** ***ligand*** ( ***FasL*** ) have been found both in lymphoid and in non-lymphoid malignancies , and are thought to play a role in the interplay between tumors and the immune system .	parallel	1
2357	10225458	1235;6364	CCR6;Mip-3alpha	***Mip-3alpha*** and its ***receptor*** ***CCR6*** were expressed in all 4 tested pancreatic cancer cell lines .	parallel	1
2358	10225462	5054;5327	PAI-1;t-PA	Forearm blood flow was assessed by venous plethysmography ; ***t-PA*** and plasminogen activator ***inhibitor*** 1 ( ***PAI-1*** ) antigen values were expressed as flow-dependent ( net release , the product of venoarterial concentration gradient and forearm blood flow ) or independent ( absolute and fractional concentration gradients ) indices .	negative	1
2359	10225948	920;3932	CD4;Lck	Studying the route via which Lck travels from its site of synthesis to the plasma membrane , we found that : ***CD4*** ***associates*** with ***Lck*** within 10 min of synthesis , long before CD4 has reached the plasma membrane ; Lck associates with intracellular CD4 early after synthesis and with cell surface CD4 at later times ; and transport of CD4-bound Lck to the plasma membrane is inhibited by Brefeldin A.	parallel	0
2360	10225948	3932;920	Lck;CD4	Studying the route via which Lck travels from its site of synthesis to the plasma membrane , we found that : CD4 associates with Lck within 10 min of synthesis , long before CD4 has reached the plasma membrane ; ***Lck*** ***associates*** with intracellular ***CD4*** early after synthesis and with cell surface CD4 at later times ; and transport of CD4-bound Lck to the plasma membrane is inhibited by Brefeldin A.	parallel	0
2361	10225948	3932;920	Lck;CD4	These data indicate that the initial ***association*** of newly synthesized ***Lck*** with ***CD4*** , and therefore with membranes , occurs on intracellular membranes of the exocytic pathway .	parallel	0
2362	10225968	3552;3569	IL-1alpha;IL-6	Endogenous ***IL-1alpha*** from systemic sclerosis fibroblasts ***induces*** ***IL-6*** and PDGF-A .	target	1
2363	10225968	3552;5154	IL-1alpha;PDGF-A	Endogenous ***IL-1alpha*** from systemic sclerosis fibroblasts ***induces*** IL-6 and ***PDGF-A*** .	target	1
2364	10225968	3552;3569	IL-1alpha;IL-6	***IL-1alpha*** ***induced*** ***IL-6*** and PDGF-A , which are potent stimulators of collagen production and proliferation in normal fibroblasts .	target	1
2365	10225968	3552;5154	IL-1alpha;PDGF-A	***IL-1alpha*** ***induced*** IL-6 and ***PDGF-A*** , which are potent stimulators of collagen production and proliferation in normal fibroblasts .	target	1
2366	10225971	4485;4486	hepatocyte growth factor-like;Ron	The ***Ron/STK*** receptor tyrosine kinase is a member of the c-Met family of receptors and is ***activated*** by ***hepatocyte growth factor-like*** protein ( HGFL ) .	positive	1
2367	10225978	3605;8600	IL-17;ODF	In addition , ***IL-17*** dose-dependently ***induced*** expression of osteoclast differentiation factor ( ***ODF*** ) mRNA in osteoblasts .	target	1
2368	10225978	4982;8600	OCIF;ODF	Osteoclastogenesis inhibitory factor ( ***OCIF*** ) , a decoy ***receptor*** of ***ODF*** , completely inhibited IL-17-induced osteoclast differentiation in the cocultures .	parallel	1
2369	10226025	5586;5170	PRK2;PDK1	***PRK2*** is a probable ***substrate*** for ***PDK1*** .	parallel	1
2370	10226032	1022;983	CAK;Cdc2	***Cdc2-cyclin*** complexes isolated from the arrested cells could be ***activated*** in vitro by recombinant ***CAK*** , whereas complexes from wild-type cells or either of the single mutants were refractory to activation .	positive	1
2371	10226073	2246;7076	FGF-1;TIMP-1	Neither FGF-1 nor ***FGF-1*** plus heparin ***affected*** the expression of ***TIMP-1*** , TIMP-2 , and gelatinase A.	target	0
2372	10226073	2246;7077	FGF-1;TIMP-2	Neither FGF-1 nor ***FGF-1*** plus heparin ***affected*** the expression of TIMP-1 , ***TIMP-2*** , and gelatinase A.	target	0
2373	10226079	3553;3576	IL-1beta;IL-8	***IL-1beta*** ***induction*** and intracellular accumulation of ***IL-8*** appeared to be unaffected by CF genotype .	target	1
2374	10226093	1051;4790	NF-IL6;NF-kappaB	CCB of all subclasses increased DNA ***binding*** of ***NF-IL6*** and ***NF-kappaB*** as early as 30 minutes after stimulation with the drugs .	parallel	1
2375	10226096	7124;5156	tumor necrosis factor-alpha;PDGF-Ralpha	Concomitantly , in quantitative reverse transcriptase-polymerase chain reaction , interleukin-1beta or ***tumor necrosis factor-alpha*** stimulation specifically ***upregulated*** the expression of ***PDGF-Ralpha*** mRNA but not of other ligand or receptor genes in cultured smooth muscle cells .	positive	1
2376	10226333	4843;4846	iNOS;eNOS	These findings suggest that the decrease in GFR after LPS is caused by local ***inhibition*** of ***eNOS*** by ***iNOS*** possibly via NO autoinhibition .	negative	1
2377	10226586	3084;2064	heregulin alpha;erbB-2	These data suggest that constitutive activation of ***erbB-2*** , erbB-3 and erbB-4 receptors could be ***induced*** by ***heregulin alpha*** via an autocrine loop mechanism , and that the active forms of erbB-4 may cooperate with the other members of the EGF-receptor family in human lung carcinogenesis .	target	1
2378	10226586	3084;2065	heregulin alpha;erbB-3	These data suggest that constitutive activation of erbB-2 , ***erbB-3*** and erbB-4 receptors could be ***induced*** by ***heregulin alpha*** via an autocrine loop mechanism , and that the active forms of erbB-4 may cooperate with the other members of the EGF-receptor family in human lung carcinogenesis .	target	1
2379	10226590	3082;1499	HGF;beta-catenin	Immunoprecipitation studies revealed that ***HGF/SF*** ***elevated*** the level of tyrosine-phosphorylated ***beta-catenin*** within these cells together with reducing the amount of E-cadherin that was observed to co-precipitate with the beta-catenin .	positive	0
2380	10226590	3082;1499	HGF;beta-catenin	We conclude that ***phosphorylation*** of ***beta-catenin*** by ***HGF/SF*** affects its association with E-cadherin at the cell surface and thus regulates E-cadherin function resulting in colony scattering phenomena .	target	1
2381	10226590	1499;999	beta-catenin;E-cadherin	We conclude that phosphorylation of ***beta-catenin*** by HGF/SF affects its association with E-cadherin at the cell surface and thus ***regulates*** ***E-cadherin*** function resulting in colony scattering phenomena .	target	1
2382	10226596	3082;1499	HGF;beta-catenin	Using immunoprecipitation , ***HGF/SF*** ***induced*** tyrosine phosphorylation of ***beta-catenin*** but not desmoplakin .	target	1
2383	10226803	5443;3484	ACTH;IGFBP-1	***ACTH*** treatment predominantly ***increased*** the abundance of ***IGFBP-1*** and to a lesser extent IGFBP-3 in a time and dose-dependent fashion .	positive	0
2384	10226804	3552;3484	Interleukin-1 alpha;insulin-like growth factor binding protein-1	***Interleukin-1 alpha*** ( IL-1 alpha ) and tumor necrosis factor alpha ( TNF alpha ) ***regulate*** ***insulin-like growth factor binding protein-1*** ( IGFBP-1 ) levels and mRNA abundance in vivo and in vitro .	target	1
2385	10226804	7124;3484	tumor necrosis factor alpha;insulin-like growth factor binding protein-1	Interleukin-1 alpha ( IL-1 alpha ) and ***tumor necrosis factor alpha*** ( TNF alpha ) ***regulate*** ***insulin-like growth factor binding protein-1*** ( IGFBP-1 ) levels and mRNA abundance in vivo and in vitro .	target	1
2386	10226804	3552;3484	IL-1 alpha;IGFBP-1	We conclude that ***IL-1 alpha*** and TNF alpha ***increase*** circulating levels of ***IGFBP-1*** , reflecting direct effects on hepatic IGFBP-1 mRNA abundance .	positive	0
2387	10226804	7124;3484	TNF alpha;IGFBP-1	We conclude that IL-1 alpha and ***TNF alpha*** ***increase*** circulating levels of ***IGFBP-1*** , reflecting direct effects on hepatic IGFBP-1 mRNA abundance .	positive	0
2388	10226805	3486;3479	IGFBP-3;IGF-I	To determine if any human proteases act this way , we first studied plasma prekallikrein since it can copurify with IGFBP-3 , and found : 1 ) [ 125 ] IGFBP-3 binds to prekallikrein immobilized either on nitrocellulose or on immunocapture plates ; 2 ) the IGFBP-3 heparin binding domain participates in forming the IGFBP-3/prekallikrein complex ; 3 ) the binary ***IGFBP-3/prekallikrein*** complex can ***bind*** ***IGF-I*** to form a ternary complex ; and 4 ) activation of prekallikrein to alpha-kallikrein by Factor XIIa resulted in proteolysis of bound IGFBP-3 .	parallel	1
2389	10226806	3489;3481	IGFBP-6;IGF-II	***IGFBP-6*** is a relatively specific ***inhibitor*** of ***IGF-II*** actions ; it has not been shown to potentiate IGF actions .	negative	1
2390	10227387	5966;4792	Rel;IkappaB alpha	Numerous studies have shown that stimulus-dependent ***Rel*** activation ***requires*** degradation of ***IkappaB alpha*** , p105 or other member of the IkappaB family , and that this process is precluded by agents that inhibit proteasome activity .	target	0
2391	10227387	5966;4790	Rel;p105	Numerous studies have shown that stimulus-dependent ***Rel*** activation ***requires*** degradation of IkappaB alpha , ***p105*** or other member of the IkappaB family , and that this process is precluded by agents that inhibit proteasome activity .	target	0
2392	10227387	6714;5971	Src;RelB	We show that treatment of SR1 cells with proteasome inhibitors abolishes RelB activity and thus suggest that RelB in these cells is associated with IkappaB and that ***v-Src*** transformation ***activates*** ***RelB*** by accelerating IkappaB proteolysis .	positive	1
2393	10227388	871;928	Hsp47;CD9	Cell surface ***colligin/Hsp47*** ***associates*** with tetraspanin protein ***CD9*** in epidermoid carcinoma cell lines .	parallel	0
2394	10227390	3953;3952	OB-R;leptin	Evidence for ligand-independent homo-oligomerization of ***leptin*** ***receptor*** ( ***OB-R*** ) isoforms : a proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression .	parallel	1
2395	10227390	3953;3952	OB-R;leptin	The adipocyte secreted hormone ***leptin*** ( OB ) and its ***receptor*** ( ***OB-R*** ) are key regulators of mammalian body weight homeostasis .	parallel	1
2396	10227428	3456;355	IFN-beta;CD95	Additional in vitro studies showed that ***IFN-beta*** indeed rapidly ( within 24 h ) ***upregulates*** ***CD95*** expression on both primed and unprimed T cells and augments the release of sCD95 in culture supernatants .	positive	1
2397	10227429	3574;3458	IL-7;IFN-gamma	***IL-7*** was found to ***enhance*** proliferation responses and ***IFN-gamma*** secretion of myelin or recall Ag-specific Th1 cells through the selective up-regulation of the IL-2Ralpha and gamma but not beta chains in both an Ag-dependent and Ag-independent manner , but did not affect monocytes , B cells , or NK cells .	positive	0
2398	10227719	356;355	FasL;Fas	Two cytotoxic mechanisms of CTL have been demonstrated : one perforin/granzyme-based and the other Fas ( CD95 ) / ***Fas*** ***ligand*** ( ***FasL*** ) - based .	parallel	1
2399	10227805	2625;3458	GATA-3;IFN-gamma	***GATA-3*** significantly ***downregulates*** ***IFN-gamma*** production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels .	negative	1
2400	10227805	2625;3458	GATA-3;IFN-gamma	We now show that ectopic expression of ***GATA-3*** in developing Th1 cells significantly ***inhibits*** ***IFN-gamma*** , as well as enhancing IL-4 and IL-5 production .	negative	1
2401	10227805	2625;3458	GATA-3;IFN-gamma	Furthermore , ***GATA-3*** ***inhibits*** production of ***IFN-gamma*** by developing Th1 cells in the complete absence of IL-4 .	negative	1
2402	10227816	959;958	CD40L;CD40	Whereas normals utilized ******CD40/CD40L****** ***interactions*** and IL-12 production for optimal interferon-gamma costimulation in PHA-stimulated cocultures , familial patient interferon-gamma production was low and unaffected by their blockade .	parallel	1
2403	10227816	959;958	CD40L;CD40	Thus , we demonstrate that the familial defect also involves interferon-gamma costimulation pathways requiring both ******CD40/CD40L****** ***interaction*** and IL-12 production , while residual pathways remain that allow low-level interferon-gamma production .	parallel	1
2404	10227974	3606;3458	IL-18;IFN-gamma	As a part of our ongoing studies on the molecular mechanisms of IL-18-induced IFN-gamma production , we have examined the transcriptional ***regulation*** of the ***IFN-gamma*** gene by ***IL-18*** in a human myelomonocytic cell line , KG-1 .	target	1
2405	10227974	3606;3458	IL-18;IFN-gamma	Transient transfection of promoter-reporter gene constructs revealed that the KBBsite is required for full ***IL-18-induced*** ***activation*** of the ***IFN-gamma*** gene transcription induced by IL-18 .	positive	1
2406	10227974	3606;3458	IL-18;IFN-gamma	These results are the first to show the actual significance of the NF-kappa B pathway in the ***regulation*** of ***IFN-gamma*** gene expression by ***IL-18*** .	target	1
2407	10227975	3606;3596	IL-18;IL-13	In this study , we found strong ***induction*** of ***IL-13*** mRNA and protein by IL-2 + ***IL-18*** in NK and T cells .	target	1
2408	10227975	3458;3596	IFN-gamma;IL-13	These results suggest ***IL-13*** expression induced by IL-2 + IL-18 may be ***regulated*** by ***IFN-gamma*** in vivo , while IL-10 expression may be IFN-gamma-independent .	target	1
2409	10227981	3458;5284	IFN-gamma;pIgR	Using an RNase protection assay , we found that IL-4 and ***IFN-gamma*** ***increase*** steady state levels of ***pIgR*** mRNA in both human intestinal ( HT29 ) and airway ( Calu-3 ) epithelial cells .	positive	0
2410	10227981	3565;5284	IL-4;pIgR	Using an RNase protection assay , we found that ***IL-4*** and IFN-gamma ***increase*** steady state levels of ***pIgR*** mRNA in both human intestinal ( HT29 ) and airway ( Calu-3 ) epithelial cells .	positive	0
2411	10227981	3458;3659	IFN-gamma;IRF-1	Both ***IFN-gamma*** and IL-4 ***increased*** expression of the inducible transcription factor IFN regulatory factor-1 ( ***IRF-1*** ) , but levels of IRF-1 only weakly correlated with levels of pIgR mRNA , suggesting that additional transcription factors are required .	positive	0
2412	10227981	3565;3659	IL-4;IRF-1	Both IFN-gamma and ***IL-4*** ***increased*** expression of the inducible transcription factor IFN regulatory factor-1 ( ***IRF-1*** ) , but levels of IRF-1 only weakly correlated with levels of pIgR mRNA , suggesting that additional transcription factors are required .	positive	0
2413	10227991	3683;3383	LFA-1;ICAM-1	***LFA-1*** ***binding*** to ***ICAM-1*** can enhance TCR-dependent proliferation of T cells , but it has been difficult to distinguish contributions from increased adhesion , and thus TCR occupancy , versus costimulatory signaling .	parallel	1
2414	10227994	355;356	Fas;Fas ligand	Activation-induced cell death of peripheral T cells results from the ***interaction*** between ***Fas*** and ***Fas ligand*** .	parallel	1
2415	10227994	8837;355	FLIP;Fas	TCR activation decreases the steady state protein levels of ***FLIP*** ( FLICE-like inhibitory protein ) , an ***inhibitor*** of the ***Fas*** signaling pathway .	negative	1
2416	10227996	3565;7124	IL-4;TNF-alpha	***IL-4*** ***inhibits*** the production of ***TNF-alpha*** and IL-12 by STAT6-dependent and - independent mechanisms .	negative	1
2417	10227996	3565;7124	IL-4;TNF-alpha	***IL-4*** failed to ***inhibit*** the release of ***TNF-alpha*** or IL-12 from STAT6 null macrophages stimulated with LPS alone .	negative	1
2418	10227996	3565;7124	IL-4;TNF-alpha	These data show that STAT6 is required for the ***IL-4-mediated*** ***inhibition*** of the production of ***TNF-alpha*** and IL-12 stimulated by LPS alone , but that IL-4 also activates distinct , STAT6 independent mechanism ( s ) that inhibit the IFN-gamma-mediated enhancement of IL-12 and TNF-alpha production .	negative	1
2419	10228003	5788;933	CD45;CD22	***CD45*** ***regulates*** tyrosine phosphorylation of ***CD22*** and its association with the protein tyrosine phosphatase SHP-1 .	target	1
2420	10228003	5777;933	SHP-1;CD22	Catalytically inactive ***SHP-1*** expressed in CD45-deficient cells ***interacted*** with ***CD22*** and decreased phosphatase activity in CD22 immunoprecipitates to levels that were comparable to those in CD45-positive cells .	parallel	1
2421	10228003	5788;933	CD45;CD22	These results indicate that ***CD45*** ***regulates*** tyrosine phosphorylation of ***CD22*** and binding of SHP-1 .	target	1
2422	10228003	5788;5777	CD45;SHP-1	These results indicate that ***CD45*** ***regulates*** tyrosine phosphorylation of CD22 and binding of ***SHP-1*** .	target	1
2423	10228004	356;355	Fas ligand;CD95	RT-PCR and FACS analyses revealed the expression of CD95 ( Fas ) by XS52 DC and of ***CD95*** ***ligand*** ( CD95L ) ( ***Fas ligand*** ) by activated HDK-1 T cells , suggesting a functional role for these molecules .	parallel	1
2424	10228008	959;5966	CD40L;c-Rel	Electrophoretic mobility shift assays showed that ***p50/p65/c-Rel*** and STAT-6 are effectively ***induced*** by ***CD40L*** and IL-4 , respectively , and bind to specific DNA motifs within the ECS .	target	1
2425	10228008	959;4790	CD40L;p50	Electrophoretic mobility shift assays showed that ***p50/p65/c-Rel*** and STAT-6 are effectively ***induced*** by ***CD40L*** and IL-4 , respectively , and bind to specific DNA motifs within the ECS .	target	1
2426	10228008	959;5970	CD40L;p65	Electrophoretic mobility shift assays showed that ***p50/p65/c-Rel*** and STAT-6 are effectively ***induced*** by ***CD40L*** and IL-4 , respectively , and bind to specific DNA motifs within the ECS .	target	1
2427	10228008	959;6778	CD40L;STAT-6	Electrophoretic mobility shift assays showed that p50/p65/c-Rel and ***STAT-6*** are effectively ***induced*** by ***CD40L*** and IL-4 , respectively , and bind to specific DNA motifs within the ECS .	target	1
2428	10228008	3565;5966	IL-4;c-Rel	Electrophoretic mobility shift assays showed that ***p50/p65/c-Rel*** and STAT-6 are effectively ***induced*** by CD40L and ***IL-4*** , respectively , and bind to specific DNA motifs within the ECS .	target	1
2429	10228008	3565;4790	IL-4;p50	Electrophoretic mobility shift assays showed that ***p50/p65/c-Rel*** and STAT-6 are effectively ***induced*** by CD40L and ***IL-4*** , respectively , and bind to specific DNA motifs within the ECS .	target	1
2430	10228008	3565;5970	IL-4;p65	Electrophoretic mobility shift assays showed that ***p50/p65/c-Rel*** and STAT-6 are effectively ***induced*** by CD40L and ***IL-4*** , respectively , and bind to specific DNA motifs within the ECS .	target	1
2431	10228008	3565;6778	IL-4;STAT-6	Electrophoretic mobility shift assays showed that p50/p65/c-Rel and ***STAT-6*** are effectively ***induced*** by CD40L and ***IL-4*** , respectively , and bind to specific DNA motifs within the ECS .	target	1
2432	10228009	5970;4790	p65;p50	IL-17 induced NF-kappa B protein-DNA complexes consisting of ******p65/p50****** ***heterodimers*** in the rat intestinal epithelial cell line IEC-6 .	parallel	1
2433	10228009	3605;4790	IL-17;NF-kappa B	***IL-17*** ***induced*** ***NF-kappa B*** protein-DNA complexes consisting of p65/p50 heterodimers in the rat intestinal epithelial cell line IEC-6 .	target	1
2434	10228009	3605;4790	IL-17;NF-kappa B	***IL-17*** acted in a synergistic fashion with IL-1 beta to ***induce*** the ***NF-kappa B*** site-dependent CINC promoter .	target	1
2435	10228009	1147;3605	I kappa B kinase-alpha;IL-17	Furthermore , ***IL-17*** induction of the CINC promoter could be ***inhibited*** by kinase-negative mutants of NF-kappa B-inducing kinase and ***I kappa B kinase-alpha*** .	positive	1
2436	10228009	3605;5594	IL-17;p38	In addition to activation of the NF-kappa B , ***IL-17*** ***regulated*** the activities of extracellular regulated kinase , c-Jun N-terminal kinase , and ***p38*** mitogen-activated protein kinases in IEC-6 cells .	target	1
2437	10228010	3002;5552	granzyme B;serglycin	To learn how the ***interaction*** of ***granzyme B*** ( GrB ) with ***serglycin*** might influence the apoptotic potential of this proteases , we have evaluated a model system where desalted CS is combined with isolated human granzyme .	parallel	1
2438	10228026	6647;4790	homodimer;NF-kappa B	Thrombin-induced p65 ***homodimer*** ***binding*** to downstream ***NF-kappa B*** site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion .	parallel	1
2439	10228026	5970;4790	p65;NF-kappa B	Thrombin-induced ***p65*** homodimer ***binding*** to downstream ***NF-kappa B*** site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion .	parallel	1
2440	10228026	6647;3383	homodimer;ICAM-1	Thrombin-induced p65 ***homodimer*** binding to downstream NF-kappa B site of the promoter ***mediates*** endothelial ***ICAM-1*** expression and neutrophil adhesion .	target	0
2441	10228026	5970;3383	p65;ICAM-1	Thrombin-induced ***p65*** homodimer binding to downstream NF-kappa B site of the promoter ***mediates*** endothelial ***ICAM-1*** expression and neutrophil adhesion .	target	0
2442	10228043	958;959	CD40;CD40 ligand	The data demonstrate that functional ******CD40-CD40 ligand****** ***interactions*** are essential for the selection of natural self-reactive B cell repertoires .	parallel	1
2443	10228066	1440;3687	G-CSF;CD11b/c	***G-CSF*** pretreatment ***up-regulated*** ***CD11b/c*** expression on circulating polymorphonuclear leukocytes , augmented the recruitment of neutrophils into the lung , and enhanced the phagocytic activity of circulating and recruited neutrophils in both the absence and presence of acute ethanol intoxication .	positive	1
2444	10228066	1440;2920	G-CSF;MIP-2	***G-CSF*** ***inhibited*** ***MIP-2*** but not TNF-alpha production in the lung .	negative	1
2445	10228073	3586;3458	IL-10;IFN-gamma	***Anti-IL-10*** also ***up-regulated*** SEA-specific ***IFN-gamma*** protein and mRNA responses in most splenocyte cultures from hepatosplenic schistosomiasis patients but had no effect on antigen-specific IL-4 or IL-5 production .	positive	1
2446	10228140	3458;6347	IFN-gamma;MCP-1	***IFN-gamma*** ***enhanced*** the BCG-mediated MIP-1alpha and ***MCP-1*** expression in a concentration-dependent manner .	positive	0
2447	10228140	3458;6348	IFN-gamma;MIP-1alpha	***IFN-gamma*** ***enhanced*** the BCG-mediated ***MIP-1alpha*** and MCP-1 expression in a concentration-dependent manner .	positive	0
2448	10228140	3565;6347	IL-4;MCP-1	***IL-4*** ***inhibited*** the BCG-mediated MIP-1alpha and ***MCP-1*** expression in a concentration-dependent manner .	negative	1
2449	10228140	3565;6348	IL-4;MIP-1alpha	***IL-4*** ***inhibited*** the BCG-mediated ***MIP-1alpha*** and MCP-1 expression in a concentration-dependent manner .	negative	1
2450	10228155	8945;1499	FWD1;beta-catenin	An F-box protein , ***FWD1*** , ***mediates*** ubiquitin-dependent proteolysis of ***beta-catenin*** .	target	0
2451	10228155	8945;8312	FWD1;Axin	Here we show that ***FWD1*** ( the mouse homologue of Slimb/betaTrCP ) , an F-box/WD40-repeat protein , specifically formed a multi-molecular ***complex*** with beta-catenin , ***Axin*** , GSK-3beta and APC .	parallel	1
2452	10228155	8945;1499	FWD1;beta-catenin	Here we show that ***FWD1*** ( the mouse homologue of Slimb/betaTrCP ) , an F-box/WD40-repeat protein , specifically formed a multi-molecular ***complex*** with ***beta-catenin*** , Axin , GSK-3beta and APC .	parallel	1
2453	10228155	8945;2932	FWD1;GSK-3beta	Here we show that ***FWD1*** ( the mouse homologue of Slimb/betaTrCP ) , an F-box/WD40-repeat protein , specifically formed a multi-molecular ***complex*** with beta-catenin , Axin , ***GSK-3beta*** and APC .	parallel	1
2454	10228155	8945;1499	FWD1;beta-catenin	***FWD1*** facilitated ubiquitination and ***promoted*** degradation of ***beta-catenin*** , resulting in reduced cytoplasmic beta-catenin levels .	positive	0
2455	10228155	8945;1499	FWD1;beta-catenin	In contrast , a dominant-negative mutant form of ***FWD1*** inhibited the ubiquitination process and ***stabilized*** ***beta-catenin*** .	positive	0
2456	10228155	8945;1499	FWD1;beta-catenin	These results suggest that the Skp1/Cullin/F-box protein FWD1 ( SCFFWD1 ) - ubiquitin ligase complex is involved in beta-catenin ubiquitination and that ***FWD1*** serves as an intracellular ***receptor*** for phosphorylated ***beta-catenin*** .	parallel	1
2457	10228156	10527;3005	importin 7;histone H1	The importin ***beta/importin 7*** heterodimer is a functional nuclear import ***receptor*** for ***histone H1*** .	parallel	1
2458	10228162	2185;6772	Pyk2;Stat1	Protein tyrosine kinase ***Pyk2*** ***mediates*** the Jak-dependent activation of MAPK and ***Stat1*** in IFN-gamma , but not IFN-alpha , signaling .	target	0
2459	10228162	2185;3717	Pyk2;Jak2	***Pyk2*** is selectively ***associated*** with ***Jak2*** and activated by IFN-gamma .	parallel	0
2460	10228162	3458;5594	IFN-gamma;Erk2	Overexpression of PKM , a dominant interfering form of Pyk2 , in NIH 3T3 cells results in a strong inhibition of the ***IFN-gamma-induced*** ***activation*** of ***Erk2*** , serine phosphorylation of Stat1 and Stat1-dependent gene transcription .	positive	1
2461	10228165	7132;7186	TNFR1;TRAF2	Although both LMP1 and ***TNFR1*** ***interact*** with TRADD and ***TRAF2*** , the different topologies of the signaling complexes correlate with substantial differences between LMP1 and TNFR1 signal transduction to JNK1 .	parallel	1
2462	10228165	7132;5599	TNFR1;JNK1	Further downstream , ***JNK1*** ***activation*** by ***TNFR1*** involves Cdc42 , whereas LMP1 signaling to JNK1 is independent of p21 Rho-like GTPases .	positive	1
2463	10228168	10413;632	YAP;osteocalcin	The ***osteocalcin*** promoter was ***stimulated*** by exogenous PEBP2alphaA and a dominant negative form of ***YAP*** strongly inhibited this activity , suggesting YAP involvement in this promoter activity in vivo .	positive	0
2464	10228171	29107;10482	p15;TAP	Both the FG-repeat domain of nucleoporin CAN/Nup214 and a novel human 15 kDa protein ( ***p15*** ) with homology to NTF2 ( a nuclear transport factor which associates with RanGDP ) , directly ***bind*** to ***TAP*** .	parallel	1
2465	10228171	10482;29107	TAP;p15	Thus , the human ******TAP-p15****** ***complex*** can functionally replace the Mex67p-Mtr2p complex in yeast and thus performs a conserved role in nuclear mRNA export .	parallel	1
2466	10228590	7066;4352	TPO;Mpl	In this paper , the relation between HEL cell metabolism and the ***activation*** of receptor ***Mpl*** by its ligand ***TPO*** was also studied .	positive	1
2467	10228949	7124;5270	tumor necrosis factor-alpha;Protease nexin I	***Protease nexin I*** secretion is ***stimulated*** by ***tumor necrosis factor-alpha*** , transforming growth factor-beta and interleukin-1 .	positive	0
2468	10229072	4690;3937	Nck;SLP-76	***Association*** of ***Nck*** with tyrosine-phosphorylated ***SLP-76*** in activated T lymphocytes .	parallel	0
2469	10229072	4690;3937	Nck;SLP-76	In vitro experiments show that the ***interaction*** between ***Nck*** and ***SLP-76*** is mediated via the Nck SH2 domain .	parallel	1
2470	10229095	3458;4261	IFN-gamma;CIITA	In this study , we investigated the effects of various immunomodulatory cytokines on ***IFN-gamma*** ***induction*** of class II MHC and ***CIITA*** gene expression in microglia , both primary microglia and a murine microglial cell line , EOC 20 .	target	1
2471	10229095	3586;4261	IL-10;CIITA	TGF-beta1 , IL-4 , and ***IL-10*** ***inhibition*** of IFN-gamma-induced ***CIITA*** mRNA accumulation was not due to destabilization of CIITA mRNA , suggesting an effect at the level of transcription .	negative	1
2472	10229095	3586;4261	IL-10;CIITA	In primary murine microglia , ***IL-10*** and TGF-beta1 ***inhibited*** IFN-gamma-induced ***CIITA*** and class II MHC expression .	negative	1
2473	10229095	7040;4261	TGF-beta1;CIITA	In primary murine microglia , IL-10 and ***TGF-beta1*** ***inhibited*** IFN-gamma-induced ***CIITA*** and class II MHC expression .	negative	1
2474	10229103	959;958	CD154;CD40	While the ***binding*** of ***CD154*** to ***CD40*** induces the assembly of a CD40-TRAF receptor complex , IKK is not recruited to this complex .	parallel	1
2475	10229111	3586;942	IL-10;B7-2	By contrast , interferon-gamma raises only B7-2 and CD40 mRNA , and the ***B7-2*** increase is ***inhibited*** by ***IL-10*** .	negative	1
2476	10229111	3458;942	interferon-gamma;B7-2	By contrast , ***interferon-gamma*** ***raises*** only ***B7-2*** and CD40 mRNA , and the B7-2 increase is inhibited by IL-10 .	positive	0
2477	10229111	3458;958	interferon-gamma;CD40	By contrast , ***interferon-gamma*** ***raises*** only B7-2 and ***CD40*** mRNA , and the B7-2 increase is inhibited by IL-10 .	positive	0
2478	10229111	4803;942	NGF;B7-2	IL-4 , transforming growth factor-beta1 , and nerve growth factor ( ***NGF*** ) ***repress*** GM-CSF-induced ***B7-2*** and CD40 , but not B7-1 .	negative	1
2479	10229111	4803;958	NGF;CD40	IL-4 , transforming growth factor-beta1 , and nerve growth factor ( ***NGF*** ) ***repress*** GM-CSF-induced B7-2 and ***CD40*** , but not B7-1 .	negative	1
2480	10229111	3589;942	IL-11;B7-2	***IL-11*** , unrecognized for its effect on antigen presentation , ***represses*** GM-CSF-induced ***B7-2*** .	negative	1
2481	10229115	958;5970	p50;p65	In addition , we performed electrophoretic mobility shift analysis and determined that in microglia , the ******p50/p65****** ***heterodimer*** of NF-kappaB is activated by LPS stimulation , and is inhibited by MG132 .	parallel	1
2482	10229119	3553;3383	IL-1beta;intercellular adhesion molecule-1	TNF alpha and ***IL-1beta*** ***mediate*** ***intercellular adhesion molecule-1*** induction via microglia-astrocyte interaction in CNS radiation injury .	target	0
2483	10229119	7124;3383	TNF alpha;intercellular adhesion molecule-1	***TNF alpha*** and IL-1beta ***mediate*** ***intercellular adhesion molecule-1*** induction via microglia-astrocyte interaction in CNS radiation injury .	target	0
2484	10229163	1401;3569	CRP;IL-6	Peak ***CRP*** levels ***correlated*** well with peak ***IL-6*** levels ( r = 0.49 , p < 0.001 ) .	parallel	0
2485	10229195	1027;1017	p27Kip1;CDK2	This observation , extended to two other IL-2-dependent as well as to three IL-2-independent HTLV-I-infected T-cell lines , suggests that the lack of cyclin E-CDK2 kinase downregulation found in the late phase of HTLV-I transformation may correlate with insufficient amounts of ***p27Kip1*** ***associated*** with the cyclin ***E-CDK2*** complex .	parallel	0
2486	10229198	3481;3643	IGF-II;Insulin receptor	***Insulin receptor*** ***activation*** by ***IGF-II*** in breast cancers : evidence for a new autocrine/paracrine mechanism .	positive	1
2487	10229231	22984;356	apoptosis-linked gene 4;Fas ligand	***Regulation*** of ***Fas ligand*** expression and cell death by ***apoptosis-linked gene 4*** .	target	1
2488	10229231	22984;356	ALG-4;FasL	Overexpression of full-length ***ALG-4*** ***induced*** transcription of ***FasL*** and , consequently , apoptosis .	target	1
2489	10229231	355;356	Fas;FasL	******Fas/FasL****** ***interaction*** initiates cell death in many other systems , and its dysregulation is a mechanism by which several pathologic conditions arise .	parallel	1
2490	10229675	2247;3569	fibroblast growth factor-2;IL-6	We have previously described that the nuclear 24 kDa isoform of ***fibroblast growth factor-2*** ( FGF-2 ) is able to ***increase*** ***IL-6*** gene expression in NIH-3T3 cells .	positive	0
2491	10229683	1984;1725	eIF5A;deoxyhypusine synthase	The ***complex*** of ***deoxyhypusine synthase*** and ***ec-eIF5A*** was separated from the free enzyme and protein substrate by electrophoresis under non-denaturing conditions .	parallel	1
2492	10229797	10803;6370	CCR9;chemokine TECK	Cutting edge : identification of the orphan chemokine receptor GPR-9-6 as ***CCR9*** , the ***receptor*** for the ***chemokine TECK*** .	parallel	1
2493	10229797	10803;6370	GPR-9-6;TECK	These results confirm that ***GPR-9-6*** is a specific ***receptor*** for ***TECK*** .	parallel	1
2494	10229804	4068;6504	SAP;CDw150	Patients with X-linked lymphoproliferative disease have mutations in a gene encoding a protein , ***DSHP/SAP*** , which ***interacts*** with ***CDw150*** and is expressed in B cells .	parallel	1
2495	10229815	1493;3558	CTLA-4;IL-2	***CTLA-4*** engagement by mAbs ***inhibits*** , while CD28 enhances , ***IL-2*** production and proliferation upon T cell activation .	negative	1
2496	10229815	1493;3558	CTLA-4;IL-2	***CTLA-4*** ligation ***inhibited*** CD3/CD28-induced ***IL-2*** mRNA accumulation by inhibiting IL-2 transcription , which appears to be mediated in part through decreasing NF-AT accumulation in the nuclei .	negative	1
2497	10229820	2246;4790	Fibroblast growth factor-1;NF-kappaB	***Fibroblast growth factor-1*** ( FGF-1 ) ***enhances*** IL-2 production and nuclear translocation of ***NF-kappaB*** in FGF receptor-bearing Jurkat T cells .	positive	0
2498	10229820	2246;3558	Fibroblast growth factor-1;IL-2	***Fibroblast growth factor-1*** ( FGF-1 ) ***enhances*** ***IL-2*** production and nuclear translocation of NF-kappaB in FGF receptor-bearing Jurkat T cells .	positive	0
2499	10229821	3565;598	IL-4;Bcl-xL	We report that 1 ) the mature DN T cells are highly resistant to TCR cross-linking-induced apoptosis in the presence of exogenous IL-4 ; 2 ) Fas/Fas-ligand and TNF-alpha/TNFR pathways do not play an apparent role in regulating apoptosis in DN T cells ; 3 ) the DN T cells constitutively express a high level of Bcl-xL , but not Bcl-2 ; 4 ) both Bcl-xL and Bcl-2 are up-regulated following TCR-cross-linking ; and 5 ) ***IL-4*** stimulation significantly ***up-regulates*** ***Bcl-xL*** and c-Jun expression and leads to mitogen-activated protein kinase phosphorylation in DN T cells , which may contribute to the resistance to apoptosis in these T cells .	positive	1
2500	10229821	3565;3725	IL-4;c-Jun	We report that 1 ) the mature DN T cells are highly resistant to TCR cross-linking-induced apoptosis in the presence of exogenous IL-4 ; 2 ) Fas/Fas-ligand and TNF-alpha/TNFR pathways do not play an apparent role in regulating apoptosis in DN T cells ; 3 ) the DN T cells constitutively express a high level of Bcl-xL , but not Bcl-2 ; 4 ) both Bcl-xL and Bcl-2 are up-regulated following TCR-cross-linking ; and 5 ) ***IL-4*** stimulation significantly ***up-regulates*** Bcl-xL and ***c-Jun*** expression and leads to mitogen-activated protein kinase phosphorylation in DN T cells , which may contribute to the resistance to apoptosis in these T cells .	positive	1
2501	10229825	940;3458	CD28;IFN-gamma	These findings illustrate costimulatory pathways that result in potent IFN-gamma responses by NK cells and show that although IL-18 and ***anti-CD28*** can ***enhance*** the synthesis of IL-12-driven ***IFN-gamma*** , they employ molecular mechanisms that are distinct from one another .	positive	0
2502	10229825	3606;3458	IL-18;IFN-gamma	These findings illustrate costimulatory pathways that result in potent IFN-gamma responses by NK cells and show that although ***IL-18*** and anti-CD28 can ***enhance*** the synthesis of IL-12-driven ***IFN-gamma*** , they employ molecular mechanisms that are distinct from one another .	positive	0
2503	10229836	7852;6387	CXCR4;stromal cell-derived factor-1	Genes encoding ***stromal cell-derived factor-1*** and its ***receptor*** ***CXCR4*** were detected in the cortex by in situ hybridization .	parallel	1
2504	10229837	4609;7852	c-Myc;CXCR4	***USF/c-Myc*** ***enhances*** , while Yin-Yang 1 suppresses , the promoter activity of ***CXCR4*** , a coreceptor for HIV-1 entry .	positive	0
2505	10229837	7528;7852	YY1;CXCR4	In this study , we show that USF/c-Myc up-regulates , while ***YY1*** ***down-regulates*** the promoter activity of ***CXCR4*** , a coreceptor for T cell-tropic HIV-1 entry .	negative	1
2506	10229837	4609;7852	c-Myc;CXCR4	Mutation of the E box abolished ***USF/c-Myc-mediated*** ***up-regulation*** of ***CXCR4*** promoter activity , and mutation of the YY1 binding site was associated with unresponsiveness to YY1-mediated inhibition .	positive	1
2507	10229845	5284;973	pIgR;IgA	The human polymeric Ig receptor ( ***pIgR*** ) , also called transmembrane secretory component , is expressed basolaterally on exocrine epithelia , and ***mediates*** specific external transport of dimeric ***IgA*** and pentameric IgM .	target	0
2508	10229845	5284;959	pIgR;IgM	The human polymeric Ig receptor ( ***pIgR*** ) , also called transmembrane secretory component , is expressed basolaterally on exocrine epithelia , and ***mediates*** specific external transport of dimeric IgA and pentameric ***IgM*** .	target	0
2509	10229845	5284;973	pIgR;IgA	While the human ***pIgR*** ***binds*** both dimeric ***IgA*** and pentameric IgM with high affinity , the rabbit counterpart has virtually no binding capacity for pentameric IgM .	parallel	1
2510	10229845	5284;959	pIgR;IgM	While the human ***pIgR*** ***binds*** both dimeric IgA and pentameric ***IgM*** with high affinity , the rabbit counterpart has virtually no binding capacity for pentameric IgM .	parallel	1
2511	10229854	3606;3458	IL-18;IFN-gamma	***IL-18*** ***enhanced*** M. leprae-induced ***IFN-gamma*** production rapidly ( 24 h ) by NK cells and in a more sustained manner ( 5 days ) by T cells .	positive	0
2512	10229854	3606;3458	IL-18;IFN-gamma	Finally , ***IL-18*** directly ***induced*** ***IFN-gamma*** production from mycobacteria-reactive T cell clones .	target	1
2513	10229855	3586;834	IL-10;caspase 1	In contrast , ***anti-IL-10*** ***increased*** ***caspase 1*** activation , p53 expression , and apoptosis , although there was no increment in NO - production .	positive	0
2514	10229869	3565;4586	IL-4;mucin	***IL-4*** ***induces*** ***mucin*** gene expression and goblet cell metaplasia in vitro and in vivo .	target	1
2515	10229869	3565;4586	IL-4;mucin	In this study we hypothesized that ***IL-4*** ***induces*** airway epithelial cell ***mucin*** gene expression and mucous glycoconjugate production by direct action on these cells .	target	1
2516	10229869	3565;4583	IL-4;MUC2	In vitro , cultured airway epithelial cells ( NCI-H292 ) expressed IL-4R constitutively , and ***IL-4*** ( 10 ng/ml ) ***induced*** ***MUC2*** gene expression and mucous glycoconjugate production .	target	1
2517	10229869	3565;4586	IL-4;MUC5	In vivo , mouse airway epithelial cells expressed IL-4R constitutively , and ***IL-4*** ( 250 ng ) ***increased*** ***MUC5*** gene expression and Alcian blue/periodic acid-Schiff-positive staining at 24 h ; IL-4 did not increase inflammatory cell numbers in airway tissue or in bronchoalveolar lavage .	positive	0
2518	10229870	952;54776	CD38;p85	***CD38*** stimulation ***induced*** tyrosine phosphorylation of the ***p85*** regulatory subunit of PI3-K and its association with other tyrosine-phosphorylated proteins .	target	1
2519	10230404	2100;8648	ER beta;SRC-1	We demonstrate here that phosphorylation of AF-1 by MAP kinase ( MAPK ) leads to the ***recruitment*** of steroid receptor coactivator-1 ( ***SRC-1*** ) by ***ER beta*** in vitro .	target	0
2520	10230406	4792;4790	I kappa B alpha;NF-kappa B	Activation of the transcription factor NF-kappa B in response to proinflammatory stimuli requires the phosphorylation-triggered and ubiquitin-dependent degradation of the ***NF-kappa B*** ***inhibitor*** , ***I kappa B alpha*** .	negative	1
2521	10230406	8454;9978	cullin 1;ROC1	***ROC1*** , a novel SCF-associated protein , is ***recruited*** by ***cullin 1*** to form a quatemary SCFHOS-ROC1 holenzyme ( with Skp1 and the beta-TRCP homolog HOS ) .	target	0
2522	10230406	9978;4792	ROC1;I kappa B alpha	***SCFHOS-ROC1*** ***binds*** IKK beta-phosphorylated ***I kappa B alpha*** and catalyzes its ubiquitination in the presence of ubiquitin , E1 , and Cdc34 .	parallel	1
2523	10230407	51529;29882	APC11;APC2	ROC1 and ROC2 commonly interact with all cullins while ***APC11*** specifically ***interacts*** with ***APC2*** , a cullin-related APC subunit .	parallel	1
2524	10230647	821;3643	calnexin;insulin receptor	The monomeric form of P193L insulin proreceptor is retained in the endoplasmic reticulum by a ***calnexin*** and GRP78 mediated mechanism that ***reduces*** mature ***insulin receptor*** expression on the cell surface .	negative	1
2525	10230647	3309;3643	GRP78;insulin receptor	The monomeric form of P193L insulin proreceptor is retained in the endoplasmic reticulum by a calnexin and ***GRP78*** mediated mechanism that ***reduces*** mature ***insulin receptor*** expression on the cell surface .	negative	1
2526	10230699	356;355	FasL;Fas	Sixteen seminomas with surrounding tissue containing normal and precancerous ( cis ) seminiferous tubules were examined for the expression of Fas ( CD95 , APO-1 ) and ***Fas*** ***ligand*** ( ***FasL*** ) ( CD95L ) .	parallel	1
2527	10230790	650;1621	BMP2;DBH	Phox2 proteins are , moreover , necessary for the ***induction*** of both TH and ***DBH*** by bone morphogenetic protein 2 ( ***BMP2*** ) ( which induces Phox2a/b ) and forskolin .	target	1
2528	10230790	650;8929	BMP2;Phox2a/b	Phox2 proteins are , moreover , necessary for the induction of both TH and DBH by bone morphogenetic protein 2 ( ***BMP2*** ) ( which ***induces*** ***Phox2a/b*** ) and forskolin .	target	1
2529	10231012	3336;3329	Hsp10;Hsp60	A prime candidate , however , is the chlamydial GroES homolog ***Hsp10*** , which is genetically and physiologically ***linked*** to ***Hsp60*** .	parallel	0
2530	10231020	998;396	G25K;rhoGDI	In the absence of Mg2 + , the methylation was stimulated by guanine nucleotides ( GTP , GDP and GTPgammaS ) , but in the presence of Mg2 + , only GTPgammaS stimulated the methylation which was similar to the effect on the ******G25K/rhoGDI****** ***complex*** .	parallel	1
2531	10231374	3586;3587	hIL-10;IL-10R1	Both ***hIL-10*** and vIL-10 ***bind*** to the soluble extracellular fragment of the cytokine receptor ***IL-10R1*** ( shIL-10R1 ) .	parallel	1
2532	10231435	4843;3162	iNOS;HO-1	CONCLUSIONS : Our studies demonstrate that both exogenously or ***iNOS-derived*** NO ***enhance*** ***HO-1*** expression in mesangial cells and point to regulatory interactions between the iNOS and HO pathways .	positive	0
2533	10231640	5743;4318	cox2;MMP-9	CONCLUSION : Indomethacin attenuates aneurysm growth , and its effects are mediated via inhibition of the ***cox2*** isoform of cyclooxygenase , which ***decreases*** PGE2 and ***MMP-9*** synthesis .	negative	0
2534	10232395	7040;3458	TGF-beta1;IFN-gamma	The ***suppression*** of the ***IFN-gamma*** production by ***TGF-beta1*** is shown to be an important mechanism by which TGF-beta enhances proliferation of Th2 lymphocytes .	negative	1
2535	10232396	719;718	C3aR;C3a	To elucidate the interaction of the ***C3a*** ***receptor*** ( ***C3aR*** ) with its ligand ( s ) we studied the binding of human recombinant C3a ( rC3a ) and rC3a ( desArg ) to RBL-2H3 transfectants which express the C3aR .	parallel	1
2536	10232396	718;719	C3a;C3aR	Recombinant ***C3a*** ***bound*** to the ***C3aR*** with a half maximal concentration of about 3 nM whereas no evidence for a binding of rC3a ( desArg ) could be obtained .	parallel	1
2537	10232581	581;596	Bax;Bcl-2	Mutation of threonine 169 did not affect the ***binding*** of ***Bax*** to Bax , ***Bcl-2*** , or Bcl-X ( L ) .	parallel	1
2538	10232581	581;598	Bax;Bcl-X	Mutation of threonine 169 did not affect the ***binding*** of ***Bax*** to Bax , Bcl-2 , or ***Bcl-X*** ( L ) .	parallel	1
2539	10232588	4193;7157	MDM2;p53 tumor suppressor	The ***MDM2*** protein ***regulates*** the functional activity of the ***p53 tumor suppressor*** through direct physical association .	target	1
2540	10232607	836;142	caspase-3;PARP	Subsequent degradation of poly ( ADP-ribose ) ( PAR ) , attached to p53 presumably by PAR glycohydrolase , the only reported enzyme to degrade PAR , was apparent concomitant with the onset of proteolytic processing and activation of caspase-3 , ***caspase-3-mediated*** ***cleavage*** of poly ( ADP-ribose ) polymerase ( ***PARP*** ) , and internucleosomal DNA fragmentation during the later stages of cell death .	target	1
2541	10232608	4296;5599	MLK3;JNK	Our combined data show that although ***MLK3*** is primarily an ***activator*** of the ***JNK/SAPK*** pathway , overexpression of the wild type protein leads to a transformed phenotype in NIH 3T3 cells that can be partially reversed by a synthetic MEK inhibitor .	positive	1
2542	10232608	4296;5601	MLK3;SAPK	Our combined data show that although ***MLK3*** is primarily an ***activator*** of the ***JNK/SAPK*** pathway , overexpression of the wild type protein leads to a transformed phenotype in NIH 3T3 cells that can be partially reversed by a synthetic MEK inhibitor .	positive	1
2543	10232608	4296;3725	MLK3;c-Jun	In the same cell system , ***MLK3*** preferentially ***activates*** the ***c-Jun*** NH2-terminal kinase/stress-activated protein kinase ( JNK/SAPK ) mitogen-activated protein kinase cascade and to a lesser degree the extracellular signal-regulated kinase ( ERK ) pathway .	positive	1
2544	10232610	7428;7040	VHL;TGF-beta1	We have demonstrated that the ***VHL*** tumor suppressor gene product ***represses*** ***TGF-beta1*** mRNA and protein levels ( approximately 3-4-fold ) in 786-O RCC cells by decreasing the TGF-beta1 mRNA half-life .	negative	1
2545	10232611	1029;7157	p19ARF;p53	The ***p19ARF*** product of the INK4a/ARF locus is induced in response to potentially oncogenic hyperproliferative signals and ***activates*** ***p53*** by interfering with its negative regulator , Mdm2 .	positive	1
2546	10232657	3827;9622	high-molecular weight kininogen;kallikrein	***high-molecular weight kininogen*** is the ***substrate*** for plasma ***kallikrein*** ( PKa potent kinin-generating enzyme circulating in blood , not of the same gene family ) and for hK1 .	parallel	1
2547	10232657	3817;3827	hK2;HMWK	Our results show that ***hK2*** ***cleaves*** ***HMWK*** to produce bradykinin , not Lys-bradykinin ( like hK1 ) , and the resultant heavy ( 56-kDa ) and light ( 42-kDa ) chains of HMWK show similar electrophoretic mobility to those cleaved by PK .	target	1
2548	10232679	3553;5743	IL-1beta;COX-2	Oligonucleotide decoy experiments confirmed the importance of nuclear factor kappaB ( NF-kappaB ) activation for ***COX-2*** ***induction*** by ***IL-1beta/TNF-alpha*** .	target	1
2549	10232679	7124;5743	TNF-alpha;COX-2	Oligonucleotide decoy experiments confirmed the importance of nuclear factor kappaB ( NF-kappaB ) activation for ***COX-2*** ***induction*** by ***IL-1beta/TNF-alpha*** .	target	1
2550	10232679	3553;4790	IL-1beta;NF-kappaB	Treatment with N ( G ) - nitro-L-arginine methyl ester ( L-NAME ) did not affect initial ***activation*** of ***NF-kappaB*** by ***IL-1beta/TNF-alpha*** , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h.	positive	1
2551	10232679	7124;4790	TNF-alpha;NF-kappaB	Treatment with N ( G ) - nitro-L-arginine methyl ester ( L-NAME ) did not affect initial ***activation*** of ***NF-kappaB*** by ***IL-1beta/TNF-alpha*** , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h.	positive	1
2552	10232833	4018;5444	lipoprotein;PON 1	Human serum paraoxonase ( ***PON 1*** ) is ***inactivated*** by oxidized low density ***lipoprotein*** and preserved by antioxidants .	negative	1
2553	10232871	7200;6750	thyrotropin-releasing hormone;somatostatin	Intraluminal ***thyrotropin-releasing hormone*** ***affects*** gastric ***somatostatin*** and acid secretion through its specific receptor in rats .	target	0
2554	10232871	7200;6750	TRH;somatostatin	CONCLUSIONS : These findings suggest that intraluminal ***TRH*** ***affects*** ***somatostatin*** and acid secretion in a paracrine manner via its specific receptor in the rat stomach .	target	0
2555	10233036	3952;5443	leptin;proopiomelanocortin	Relative to controls , ***leptin*** ***increased*** hypothalamic mRNA for corticotropin-releasing hormone ( CRH ; 61 % ) and for ***proopiomelanocortin*** ( POMC ; 31 % ) but did not reduce mRNA for neuropeptide Y .	positive	0
2556	10233167	2064;1956	ErbB2;epidermal growth factor (EGF) receptor	Endocytosis deficiency of ******epidermal growth factor (EGF) receptor-ErbB2****** ***heterodimers*** in response to EGF stimulation .	parallel	1
2557	10233170	5879;2247	rac1;bFGF	Activated alleles of ***rac1*** and rhoA ***blocked*** and reversed ***bFGF*** effects when introduced into astrocytes in dissociated culture and in brain slices using recombinant adenoviruses .	negative	0
2558	10233170	387;2247	rhoA;bFGF	Activated alleles of rac1 and ***rhoA*** ***blocked*** and reversed ***bFGF*** effects when introduced into astrocytes in dissociated culture and in brain slices using recombinant adenoviruses .	negative	0
2559	10233170	2247;5879	bFGF;rac1	Our results show that ***bFGF*** acting through c-Ha-Ras ***inhibits*** endogenous ***rac1*** and rhoA GTPases thereby triggering astrocyte process growth , and they provide evidence for the regulation of this cascade in vivo by a yet undetermined neuron-derived factor .	negative	1
2560	10233170	2247;387	bFGF;rhoA	Our results show that ***bFGF*** acting through c-Ha-Ras ***inhibits*** endogenous rac1 and ***rhoA*** GTPases thereby triggering astrocyte process growth , and they provide evidence for the regulation of this cascade in vivo by a yet undetermined neuron-derived factor .	negative	1
2561	10233377	1437;2056	granulocyte-macrophage colony-stimulating factor;erythropoietin	In vitro studies have indicated that ***granulocyte-macrophage colony-stimulating factor*** ( GM-CSF ) ***synergizes*** with ***erythropoietin*** ( EPO ) for the production of erythroid precursors in patients with myelodysplastic syndrome ( MDS ) .	parallel	0
2562	10233392	7066;4352	thrombopoietin;c-mpl	***thrombopoietin*** ( TPO ) is a ***ligand*** for ***c-mpl*** , which regulates the differentiation and maturation of megakaryocytes .	parallel	1
2563	10233418	5175;952	CD31;CD38	These data indicated that PC malignancies co-expressed high levels of both ***CD38*** and its ***ligand*** ***CD31*** , with the exception of plasmablastic MM and PCL .	parallel	1
2564	10233422	7066;4352	TPO;c-Mpl	This implied that binding of EPO and EPO-R was essential for erythropoiesis and the resultant signal transduction may be augmented by the signals emanating from ******TPO-c-Mpl****** ***interaction*** .	parallel	1
2565	10233423	7040;3562	TGF-beta1;interleukin-3	To investigate a possible link between the action of TGF-beta1 and cell death regulators such as bcl-2 , we utilized Ba/F3 cells , the ***interleukin-3*** ( IL-3 ) - dependent growth of which could be ***modulated*** by ***TGF-beta1*** , as well as haemopoietic progenitor cells .	target	0
2566	10233435	2150;2152	protease-activated receptor-2;tissue factor	Endothelial ***protease-activated receptor-2*** ***induces*** ***tissue factor*** expression and von Willebrand factor release .	target	1
2567	10233435	23430;2150	mast cell tryptase;PAR-2	A second protease-activated receptor ( ***PAR-2*** ) that could be ***activated*** by trypsin or more physiologically by ***mast cell tryptase*** has been recently cloned .	positive	1
2568	10233676	940;941	CD28;CD80	U937 cells provide a co-stimulatory signal for CD3-mediated T-cell activation which is independent of the ******CD28/CD80/CD86****** ***interaction*** .	parallel	1
2569	10233676	940;942	CD28;CD86	U937 cells provide a co-stimulatory signal for CD3-mediated T-cell activation which is independent of the ******CD28/CD80/CD86****** ***interaction*** .	parallel	1
2570	10233676	942;941	CD86;CD80	U937 cells provide a co-stimulatory signal for CD3-mediated T-cell activation which is independent of the ******CD28/CD80/CD86****** ***interaction*** .	parallel	1
2571	10233694	3689;682	LFA-1;CD147	The ***CD147*** mAb-induced cell aggregation was ***inhibited*** by leucocyte function-antigen-1 ( ***LFA-1*** ) and intercellular adhesion molecule-1 ( ICAM-1 ) mAbs .	negative	1
2572	10233696	4254;3574	SCF;IL-7	The convergence of the signal transduction pathways of the two cytokines is not known , thus cell line PER-487 provides a unique model for studying the synergistic ***interaction*** of ***IL-7*** and ***SCF*** .	parallel	1
2573	10233697	3600;3458	Interleukin-15;interferon-gamma	***Interleukin-15*** differentially ***enhances*** the expression of ***interferon-gamma*** and interleukin-4 in activated human ( CD4 + ) T lymphocytes .	positive	0
2574	10233697	3600;3565	Interleukin-15;interleukin-4	***Interleukin-15*** differentially ***enhances*** the expression of interferon-gamma and ***interleukin-4*** in activated human ( CD4 + ) T lymphocytes .	positive	0
2575	10233697	3600;3458	IL-15;IFN-gamma	***IFN-gamma*** and IL-4 mRNAs were ***upregulated*** by ***IL-15*** in concanavalin A - ( twofold ) and anti-CD3 plus anti-CD28 - ( fivefold ) stimulated T lymphocytes .	positive	1
2576	10233697	3600;3565	IL-15;IL-4	IFN-gamma and ***IL-4*** mRNAs were ***upregulated*** by ***IL-15*** in concanavalin A - ( twofold ) and anti-CD3 plus anti-CD28 - ( fivefold ) stimulated T lymphocytes .	positive	1
2577	10233697	3600;3458	IL-15;IFN-gamma	***IFN-gamma*** mRNA accumulation , but not IL-4 mRNA , was additively ***upregulated*** by ***IL-15*** plus IL-7 ( ninefold ) in anti-CD3 stimulated T lymphocytes , and bypassed the requirement of CD28 signalling .	positive	1
2578	10233697	3574;3458	IL-7;IFN-gamma	***IFN-gamma*** mRNA accumulation , but not IL-4 mRNA , was additively ***upregulated*** by IL-15 plus ***IL-7*** ( ninefold ) in anti-CD3 stimulated T lymphocytes , and bypassed the requirement of CD28 signalling .	positive	1
2579	10233697	3600;3458	IL-15;IFN-gamma	Fluorescence-activated cell sorting ( FACS ) experiments demonstrated that ***IFN-gamma*** mRNA was ***upregulated*** by ***IL-15*** in both CD4 + and CD8 + T lymphocytes , whereas IL-4 mRNA accumulation predominantly occurred in CD4 + cells .	positive	1
2580	10233733	942;940	CD86;CD28	Effective blockade of ******CD86/CD28****** ***interaction*** was demonstrated by elimination of interleukin ( IL ) -4 and up-regulation of interferon ( IFN ) - gamma responses by P. chabaudi-specific T cells and by reduction of P. chabaudi-specific immunoglobulin G1 ( IgG1 ) .	parallel	1
2581	10233733	941;3458	CD80;IFN-gamma	Moreover , combined ***CD80/CD86*** blockade by using anti-CD80 and anti-CD86 monoclonal antibodies ***raised*** ***IFN-gamma*** production over that seen with CD86 blockade alone , with augmentation of this Th1-associated cytokine reducing levels of peak primary parasitaemia .	negative	0
2582	10233733	942;3458	CD86;IFN-gamma	Moreover , combined ***CD80/CD86*** blockade by using anti-CD80 and anti-CD86 monoclonal antibodies ***raised*** ***IFN-gamma*** production over that seen with CD86 blockade alone , with augmentation of this Th1-associated cytokine reducing levels of peak primary parasitaemia .	negative	0
2583	10233733	940;942	CD28;CD86	These results demonstrate that IL-4 production by T cells in P. chabaudi-infected NIH mice is dependent upon ******CD86/CD28****** ***interaction*** and that IL-4 and IFN-gamma contribute significantly , at different times of infection , to host resistance to blood stage malaria .	parallel	1
2584	10233738	3565;3586	Interleukin-4;interleukin-10	***Interleukin-4*** ***regulation*** of human monocyte and macrophage ***interleukin-10*** and interleukin-12 production .	target	1
2585	10233739	3458;5284	IFN-gamma;pIgR	With this model we show here that IL-4 and ***IFN-gamma*** dose-dependently ***increased*** ***pIgR*** mRNA and protein expression , and sIgA release .	positive	0
2586	10233739	3565;5284	IL-4;pIgR	With this model we show here that ***IL-4*** and IFN-gamma dose-dependently ***increased*** ***pIgR*** mRNA and protein expression , and sIgA release .	positive	0
2587	10233739	3458;5284	IFN-gamma;pIgR	***IFN-gamma*** and IL-4 ***induced*** similar maximal expression of ***pIgR*** , but IFN-gamma enhanced sIgA release more than IL-4 .	target	1
2588	10233739	3565;5284	IL-4;pIgR	IFN-gamma and ***IL-4*** ***induced*** similar maximal expression of ***pIgR*** , but IFN-gamma enhanced sIgA release more than IL-4 .	target	1
2589	10233739	3458;5284	IFN-gamma;pIgR	When added together , IL-4 and ***IFN-gamma*** synergistically ***increased*** ***pIgR*** mRNA and protein expression , but sIgA release was stimulated in an additive manner .	positive	0
2590	10233739	3565;5284	IL-4;pIgR	When added together , ***IL-4*** and IFN-gamma synergistically ***increased*** ***pIgR*** mRNA and protein expression , but sIgA release was stimulated in an additive manner .	positive	0
2591	10233747	959;958	CD40L;CD40	Here , we have investigated whether protection of NOD mice from IDDM was associated with changes on costimulatory pathways of T and B cells , namely CD28/CTLA -4 - B7 and ***CD40-CD40*** ***ligand*** ( ***CD40L*** ) and we also further characterized protective T helper ( Th ) cells with regards to the expression of the differentiation markers CD45RB and CD38 .	parallel	1
2592	10233760	3565;1805	interleukin-4;Dermatopontin	***Dermatopontin*** expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is ***regulated*** by transforming growth factor-beta1 , ***interleukin-4*** , and matrix collagen .	target	1
2593	10233760	3565;1805	interleukin-4;Dermatopontin	Transforming growth factor-beta1 increased Dermatopontin mRNA and protein levels , while ***interleukin-4*** ***reduced*** ***Dermatopontin*** expression .	negative	1
2594	10233762	2833;3627	CXCR3;IP-10	Human IP-9 : A keratinocyte-derived high affinity CXC-chemokine ligand for the ***IP-10/Mig*** ***receptor*** ( ***CXCR3*** ) .	parallel	1
2595	10233762	2833;4283	CXCR3;Mig	Human IP-9 : A keratinocyte-derived high affinity CXC-chemokine ligand for the ***IP-10/Mig*** ***receptor*** ( ***CXCR3*** ) .	parallel	1
2596	10233770	9474;836	Asp;caspase-3	Pretreatments of the cells with a p38 mitogen-activated protein kinase inhibitor , SB203580 , and a ***caspase-3*** ***inhibitor*** , ***Ac-Asp-Met-Gln-Asp-1-aldehyde*** , suppressed the ultraviolet B irradiation-induced apoptosis by approximately 60 % as estimated by nuclear staining and DNA laddering .	negative	1
2597	10233770	9474;834	Asp;caspase-1	Pretreatment with ***caspase-1*** ***inhibitor*** , ***Ac-Tyr-Val-Lys-Asp-aldehyde*** was without effect .	negative	1
2598	10233774	4254;3815	stem cell factor;c-KIT	Previous findings indicate that the protein ***c-KIT*** and its ***ligand*** , ***stem cell factor*** ( SCF ) play a crucial role in the development of melanocytes from their precursors in the embryonic neural crest cells .	parallel	1
2599	10233774	4254;3815	SCF;c-KIT	It was therefore demonstrated that apoptosis was induced in the SCF-dependent c-KIT-positive melanocytes in vitro when the ******SCF/c-KIT****** ***interaction*** was obstructed .	parallel	1
2600	10233774	4254;3815	SCF;c-KIT	These findings elucidate the mechanism of the regulation of melanocyte development , and the survival and proliferation of these precursor cells , by ******SCF/c-KIT****** ***interaction*** .	parallel	1
2601	10233855	2621;558	Gas6;Axl	Expression of receptor tyrosine kinase ***Axl*** and its ***ligand*** ***Gas6*** in rheumatoid arthritis : evidence for a novel endothelial cell survival pathway .	parallel	1
2602	10233855	2621;558	Gas6;Axl	***Gas6*** ( for growth arrest-specific gene 6 ) , which is a ***ligand*** for ***Axl*** and is related to the coagulation factor protein S , was found in synovial fluid and tissue from patients with RA and osteoarthritis .	parallel	1
2603	10233872	4297;7157	MLL;p53	Transcriptional ***inhibition*** of ***p53*** by the ***MLL/MEN*** chimeric protein found in myeloid leukemia .	negative	1
2604	10233872	7157;4297	p53;MLL	Moreover , ***p53*** ***coimmunoprecipitated*** with ***MLL/MEN*** as well as MEN , suggesting that the fusion protein binds to p53 through the MEN region .	parallel	1
2605	10233883	3458;355	IFNgamma;Fas	These results indicate that ***IFNgamma*** acts on ECFC not only to ***upregulate*** ***Fas*** , but also to selectively upregulate caspases-1 , -3 , and -8 , which are activated and produce apoptosis , whereas the concentrations of FasL and FADD are not demonstrably changed .	positive	1
2606	10233883	3458;355	IFNgamma;Fas	Fas ( APO-1 ; CD95 ) and Fas ligand ( FasL ) mediate apoptosis induced by IFNgamma , because ***Fas*** is significantly ***upregulated*** by ***IFNgamma*** , whereas Fas ligand is constitutively present in the ECFC and neutralization of FasL greatly reduces the apoptosis .	positive	1
2607	10233883	3458;834	IFNgamma;caspase-1	RNase protection assays showed that the ***caspase-1*** , -2 , -6 , -8 , and -9 mRNAs were ***upregulated*** by ***IFNgamma*** , whereas the caspase-5 and -7 mRNAs were not increased .	positive	1
2608	10233885	4602;100073347	c-myb;mim-1	Cotransfection of ***c-myb*** with either the p32 or p30 isoform of C/EBPepsilon in CV-1 cells cooperatively ***transactivated*** the ***mim-1*** promoter by 20 - and 16-fold , respectively , and the neutrophil elastase promoter by 10-and 7-fold , respectively .	positive	1
2609	10233885	925;100073347	p32;mim-1	Consistent with this prediction , transfections into the hematopoietic cell line Jurkat showed a 9.0 - and 2.5-fold ***activation*** of the ***mim-1*** promoter by the ***p32*** and p30 isoforms , respectively .	positive	1
2610	10233887	2056;11184	Epo;HPK1	We therefore conclude that ***Epo*** ***induces*** activation of both ***HPK1*** and HS1 , whereas cellular stresses activate only HS1 , and that the HPK1-JNK / SAPK pathway is involved in Epo-induced growth and differentiation signals .	target	1
2611	10233887	2056;3059	Epo;HS1	We therefore conclude that ***Epo*** ***induces*** activation of both HPK1 and ***HS1*** , whereas cellular stresses activate only HS1 , and that the HPK1-JNK / SAPK pathway is involved in Epo-induced growth and differentiation signals .	target	1
2612	10233887	2056;11184	erythropoietin;hematopoietic progenitor kinase-1	***Activation*** of ***hematopoietic progenitor kinase-1*** by ***erythropoietin*** .	positive	1
2613	10233887	2056;11184	Epo;HPK1	We found that ***Epo*** , but not environmental stresses , ***induced*** rapid and transient activation of ***HPK1*** , whereas both induced activation of JNK/SAPK .	target	1
2614	10233887	11184;3059	HPK1;HS1	We found ***HPK1*** constitutively ***associated*** with ***HS1*** and that HS1 was tyrosine-phosphorylated in response to cellular stresses as well as Epo stimulation .	parallel	0
2615	10233889	7076;1649	Epo;CHOP	We now report that ***Epo*** markedly ***upregulates*** ***CHOP*** ( GADD153 ) expression and that this transcription factor plays a role in erythropoiesis .	positive	1
2616	10233900	7040;1215	TGF-beta1;chymase	In conclusion , the expression and extracellular release of the IMMC-specific ***chymase*** , mMCP-1 , is strictly ***regulated*** by ***TGF-beta1*** .	target	1
2617	10233905	4688;653361	p67phox;p47phox	These data support a model in which flavocytochrome b is required for stable membrane ***binding*** of ***p47phox*** and ***p67phox*** , but not their association with the cytoskeleton or transport to the cell periphery .	parallel	1
2618	10233927	9260;4790	LMP-1;NF-kappaB	A20 can be regulated by the ***NF-kappaB*** transcription factor , which is known to be ***activated*** by the EBV ***LMP-1*** protein .	positive	1
2619	10233977	7341;5371	SUMO-1;PML	Here we show that the HSV ICP0 and CMV IE1 proteins specifically abrogate the ***SUMO-1*** ***modification*** of ***PML*** and Sp100 , whereas the adenovirus E4 ORF3 protein does not affect this process .	target	0
2620	10233977	7341;6672	SUMO-1;Sp100	Here we show that the HSV ICP0 and CMV IE1 proteins specifically abrogate the ***SUMO-1*** ***modification*** of PML and ***Sp100*** , whereas the adenovirus E4 ORF3 protein does not affect this process .	target	0
2621	10234545	7124;7412	TNF-alpha;VCAM-1	Percutaneous injection of ***TNF-alpha*** ***induced*** up-regulation of ***VCAM-1*** .	target	1
2622	10234567	5744;654	PTHrP;BMP-6	These latter findings suggest that while ***PTHrP*** directly ***inhibits*** ***BMP-6*** , it indirectly regulates Ihh expression through BMP-6 .	negative	1
2623	10234571	6647;6696	homodimer;osteopontin	Several analogs were examined for their effects on DNA ***binding*** of the vitamin D receptor ( VDR ) ***homodimer*** complex with the murine ***osteopontin*** vitamin D response element .	parallel	1
2624	10234571	7421;6696	vitamin D receptor;osteopontin	Several analogs were examined for their effects on DNA ***binding*** of the ***vitamin D receptor*** ( VDR ) homodimer complex with the murine ***osteopontin*** vitamin D response element .	parallel	1
2625	10234573	1017;5925	Cdk2;pRb	This was consistent with an observed IGF-1-stimulated hyperphosphorylation of retinoblastoma protein ( pRb ) with the possibility that the activated ***Cdk2*** kinase is involved in ***phosphorylation*** of ***pRb*** in IGF-1-induced cell proliferation .	target	1
2626	10235259	355;841	Fas;caspase-8	The CED-4-homologous protein FLASH is involved in ***Fas-mediated*** ***activation*** of ***caspase-8*** during apoptosis .	positive	1
2627	10235265	8556;2313	Cdc14;Sic1	The highly conserved protein phosphatase ***Cdc14*** ***promotes*** both Clb degradation and ***Sic1*** accumulation .	positive	0
2628	10235265	8556;2313	Cdc14;Sic1	***Cdc14*** ***promotes*** ***Sic1*** transcription and the stabilization of Sic1 protein by dephosphorylating Sicl and its transcription factor Swi5 .	positive	0
2629	10235368	1019;1029	CDK4;p16	***CDK4*** , encoded by CDK4 gene , is the ***substrate*** of ***p16*** .	parallel	1
2630	10235446	3383;7448	ICAM-1;vitronectin	Furthermore , monocyte adhesion to vitronectin and fibrinogen was significantly enhanced by the lipoproteins [ respectively 2-fold and 1.7-fold increase with 200 microg/ml of ox-Lp ( a ) ] , due to the increase of micro-PAR and ***ICAM-1*** , which are ***receptors*** for ***vitronectin*** and fibrinogen .	parallel	1
2631	10235530	3479;3486	insulin-like growth factor-1;IGFBP-3	OBJECTIVE : To determine the effects of recombinant human ***insulin-like growth factor-1*** ( IGF-1 ) ***complexed*** with its principal binding protein , ***IGFBP-3*** , on skeletal muscle metabolism in severely burned children .	parallel	1
2632	10235530	3486;3479	IGFBP-3;IGF-1	The infusion of 1.0 mg/kg/day ***IGF-1/IGFBP-3*** ***increased*** serum ***IGF-1*** , which did not further increase with 2.0 and 4.0 mg/kg/day .	positive	0
2633	10235629	887;2520	CCK2 receptor;gastrin	While ***CCK2 receptor*** blockade ***prevents*** ***gastrin*** from evoking acid secretion , it is without effect on basal and vagally stimulated acid secretion .	positive	0
2634	10318759	5829;7145	paxillin;tensin	Studying the quantitative relationships between the various components of the submembrane plaque indicated that the levels of vinculin , ***paxillin*** and phosphotyrosine in adhesion sites are positively correlated with each other and negatively ***correlated*** with the levels of ***tensin*** .	negative	0
2635	10318759	7414;7145	vinculin;tensin	Studying the quantitative relationships between the various components of the submembrane plaque indicated that the levels of ***vinculin*** , paxillin and phosphotyrosine in adhesion sites are positively correlated with each other and negatively ***correlated*** with the levels of ***tensin*** .	negative	0
2636	10318769	581;599	Bax;Bcl-w	In extracts of mammary tissue in vivo , Bak heterodimerized with Bcl-x whereas ***Bax*** ***associated*** with ***Bcl-w*** , but Bak/Bcl-w heterodimers were not detected .	parallel	0
2637	10318769	578;599	Bak;Bcl-w	In extracts of mammary tissue in vivo , Bak heterodimerized with Bcl-x whereas Bax associated with Bcl-w , but ******Bak/Bcl-w****** ***heterodimers*** were not detected .	parallel	1
2638	10318779	7157;1387	p53;CBP	Because ***p53*** ***interacts*** with both MDM2 and ***CBP/p300*** through its trans-activation domain , we examined the role of MDM2 in p53-coactivator interactions .	parallel	1
2639	10318779	7157;2033	p53;p300	Because ***p53*** ***interacts*** with both MDM2 and ***CBP/p300*** through its trans-activation domain , we examined the role of MDM2 in p53-coactivator interactions .	parallel	1
2640	10318779	7157;1387	p53;CBP	MDM2 blocked CBP/p300 recruitment in vitro and inhibited the ***interaction*** of the transactivating region of ***p53*** with both the N - or C-terminal regions of ***CBP/p300*** in a mammalian two-hybrid assay .	parallel	1
2641	10318779	7157;2033	p53;p300	MDM2 blocked CBP/p300 recruitment in vitro and inhibited the ***interaction*** of the transactivating region of ***p53*** with both the N - or C-terminal regions of ***CBP/p300*** in a mammalian two-hybrid assay .	parallel	1
2642	10318789	836;1676	caspase-3;DFF45	Previous studies have shown that upon ***cleavage*** of ***DFF45*** by ***caspase-3*** , the nuclease activity of DFF40 is relieved of inhibition .	target	1
2643	10318789	840;1676	caspase-7;DFF45	We demonstrate that ***DFF45*** can also be ***cleaved*** and inactivated by ***caspase-7*** but not by caspase-6 and caspase-8 .	target	1
2644	10318789	3005;1677	histone H1;DFF40	***histone H1*** directly interacts with DFF , confers DNA binding ability to DFF , and ***stimulates*** the nuclease activity of ***DFF40*** by increasing its Kcat and decreasing its Km .	positive	0
2645	10318795	190;2516	nuclear receptor DAX-1;SF-1	We also found that the ***nuclear receptor DAX-1*** , a ***repressor*** of ***SF-1*** activity , reduced Egr-1-SF-1 synergy and diminished GnRH stimulation of the LHbeta promoter .	negative	1
2646	10318795	190;1958	nuclear receptor DAX-1;Egr-1	We also found that the ***nuclear receptor DAX-1*** , a repressor of SF-1 activity , ***reduced*** ***Egr-1-SF-1*** synergy and diminished GnRH stimulation of the LHbeta promoter .	negative	1
2647	10318795	190;2516	nuclear receptor DAX-1;SF-1	We also found that the ***nuclear receptor DAX-1*** , a repressor of SF-1 activity , ***reduced*** ***Egr-1-SF-1*** synergy and diminished GnRH stimulation of the LHbeta promoter .	negative	1
2648	10318796	7124;6197	Tumor necrosis factor-alpha;HU-3	***Tumor necrosis factor-alpha*** ( TNF-alpha ) ***stimulates*** proliferation of Mo7e , CMK , ***HU-3*** , and M-MOK human leukemic cell lines .	positive	0
2649	10318796	5970;958	p65;p50	The activated NF-kappaB consisted of ***heterodimers*** of ***p65*** and ***p50*** subunits .	parallel	1
2650	10318799	5335;79026	PLC-gamma1;AHNAK	The role of arachidonic acid was to promote a physical ***interaction*** between ***AHNAK*** and ***PLC-gamma1*** , and the activation by AHNAK and arachidonic acid was mainly attributable to reduction in the enzyme 's apparent Km toward the substrate phosphatidylinositol 4,5-bisphosphate .	parallel	1
2651	10318804	7263;3329	rhodanese;GroEL	Under native conditions , truncated ***rhodanese*** ***bound*** to ***GroEL*** and was released and reactivated by adding ATP and GroES , suggesting equilibrium between native and non-native conformers .	parallel	1
2652	10318807	896;1019	cyclin D3;Cdk4	Here we report that in UV-irradiated HeLa and A2058 cells , p16 bound Cdk4 and Cdk6 complexes with increased avidity and inhibited a ******cyclin D3-Cdk4****** ***complex*** normally activated in late S/early G2 phase .	parallel	1
2653	10318807	1029;1019	p16;Cdk4	Here we report that in UV-irradiated HeLa and A2058 cells , ***p16*** ***bound*** ***Cdk4*** and Cdk6 complexes with increased avidity and inhibited a cyclin D3-Cdk4 complex normally activated in late S/early G2 phase .	parallel	1
2654	10318807	1029;1021	p16;Cdk6	Here we report that in UV-irradiated HeLa and A2058 cells , ***p16*** ***bound*** Cdk4 and ***Cdk6*** complexes with increased avidity and inhibited a cyclin D3-Cdk4 complex normally activated in late S/early G2 phase .	parallel	1
2655	10318807	1029;1019	p16;Cdk4	Here we report that in UV-irradiated HeLa and A2058 cells , ***p16*** bound Cdk4 and Cdk6 complexes with increased avidity and ***inhibited*** a ***cyclin D3-Cdk4*** complex normally activated in late S/early G2 phase .	negative	1
2656	10318807	1029;896	p16;cyclin D3	Here we report that in UV-irradiated HeLa and A2058 cells , ***p16*** bound Cdk4 and Cdk6 complexes with increased avidity and ***inhibited*** a ***cyclin D3-Cdk4*** complex normally activated in late S/early G2 phase .	negative	1
2657	10318831	10755;10509	GIPC;SemC	While SEMCAP-1 ( ***GIPC*** ) also ***interacts*** with ***SemC*** , it does not interact with other proteins containing a class I PDZ binding motif , nor does M-SemF interact with other class I PDZ proteins .	parallel	1
2658	10318842	1051;6722	CCAAT/enhancer-binding protein beta;serum response factor	Ras regulates the ***association*** of ***serum response factor*** and ***CCAAT/enhancer-binding protein beta*** .	parallel	0
2659	10318842	1051;2220	C/EBPbeta;p35	Strikingly , in both the mammalian two-hybrid assay and in vivo coimmunoprecipitations , the ***association*** of SRF and ******p35-C/EBPbeta****** but not p20-C/EBPbeta is dramatically stimulated by activated Ras .	parallel	0
2660	10318842	1051;6722	C/EBPbeta;SRF	Strikingly , in both the mammalian two-hybrid assay and in vivo coimmunoprecipitations , the ***association*** of ***SRF*** and ***p35-C/EBPbeta*** but not p20-C/EBPbeta is dramatically stimulated by activated Ras .	parallel	0
2661	10318842	2220;6722	p35;SRF	Strikingly , in both the mammalian two-hybrid assay and in vivo coimmunoprecipitations , the ***association*** of ***SRF*** and ***p35-C/EBPbeta*** but not p20-C/EBPbeta is dramatically stimulated by activated Ras .	parallel	0
2662	10318842	1051;2220	C/EBPbeta;p35	These results suggest a new mechanism by which mitogenic signals may influence transcription activity of the SRE by selectively promoting protein-protein ***interactions*** between SRF and the transactivator ******p35-C/EBPbeta****** .	parallel	1
2663	10318842	1051;6722	C/EBPbeta;SRF	These results suggest a new mechanism by which mitogenic signals may influence transcription activity of the SRE by selectively promoting protein-protein ***interactions*** between ***SRF*** and the transactivator ***p35-C/EBPbeta*** .	parallel	1
2664	10318842	2220;6722	p35;SRF	These results suggest a new mechanism by which mitogenic signals may influence transcription activity of the SRE by selectively promoting protein-protein ***interactions*** between ***SRF*** and the transactivator ***p35-C/EBPbeta*** .	parallel	1
2665	10318843	3932;7535	Lck;ZAP-70	One essential function of ***Lck*** in this process is to ***phosphorylate*** ***ZAP-70*** and up-regulate its catalytic activity .	target	1
2666	10318843	3932;7535	Lck;ZAP-70	We have previously shown that after T-cell antigen receptor stimulation , ***Lck*** ***binds*** to ***ZAP-70*** via its Src homology 2 ( SH2 ) domain ( LckSH2 ) and , more recently , that Tyr319 of ZAP-70 is phosphorylated in vivo and plays a positive regulatory role .	parallel	1
2667	10318843	7535;3932	ZAP-70;Lck	Here , we investigated the possibility that Tyr319 mediates the SH2-dependent ***interaction*** between ***Lck*** and ***ZAP-70*** .	parallel	1
2668	10318844	5813;5814	Puralpha;Purbeta	***Interactions*** between ***Puralpha*** , ***Purbeta*** , and MSY1 do not require the participation of DNA .	parallel	1
2669	10318852	9733;3667	p110;IRS-1	Moreover , ***p110*** ( CAAX ) stimulated IRS-1 Ser/Thr phosphorylation , and ***inhibited*** ***IRS-1*** associated PI 3-kinase activity , without affecting insulin receptor tyrosine phosphorylation , suggesting that it may play an important role as a negative regulator for insulin signaling .	negative	1
2670	10318852	9733;3667	p110;IRS-1	Moreover , ***p110*** ( CAAX ) ***stimulated*** ***IRS-1*** Ser/Thr phosphorylation , and inhibited IRS-1 associated PI 3-kinase activity , without affecting insulin receptor tyrosine phosphorylation , suggesting that it may play an important role as a negative regulator for insulin signaling .	positive	0
2671	10318855	2063;7026	ear2;ARP1	Here we demonstrate that ***ARP1*** and ***ear2*** form ***heterodimers*** in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor .	parallel	1
2672	10318855	2063;7026	ear2;ARP1	Heterodimeric ***interactions*** between ***ARP1*** and ***ear2*** may define a distinct pathway of orphan receptor signaling .	parallel	1
2673	10318860	54776;4067	p85;LYN	The results demonstrate that the NO donor S-nitrosoglutathione ( S-NO-glutathione ) inhibits the stimulation of PI3-kinase associated with tyrosine-phosphorylated proteins and of ***p85/PI3-kinase*** ***associated*** with the SRC family kinase member ***LYN*** following the exposure of platelets to thrombin receptor-activating peptide .	parallel	0
2674	10318861	1398;2889	Crk;C3G	Deletion of the amino terminus of C3G to amino acid 61 did not remarkably affect either tyrosine phosphorylation or ***Crk-dependent*** ***activation*** of ***C3G*** .	positive	1
2675	10318861	1398;2889	Crk;C3G	Deletion of the amino terminus of C3G to amino acid 579 significantly reduced the ***Crk-dependent*** tyrosine ***phosphorylation*** of ***C3G*** and increased GTP-bound Rap1 irrespective of the presence of CrkI .	target	1
2676	10318863	5790;3932	CD45-AP;Lck	Moreover , they raise the possibility that one of the functions of ***CD45-AP*** is to ***recognize*** activated ***Lck*** molecules and bring them into the vicinity of CD45 .	target	1
2677	10318863	5790;920	CD45-AP;CD4	The ***association*** of ***CD45-AP*** with TCR , ***CD4*** , and CD8 seemed to occur via the shared ability of these molecules to bind CD45 .	parallel	0
2678	10318863	5790;925	CD45-AP;CD8	The ***association*** of ***CD45-AP*** with TCR , CD4 , and ***CD8*** seemed to occur via the shared ability of these molecules to bind CD45 .	parallel	0
2679	10318863	5790;3932	CD45-AP;Lck	However , ***binding*** of ***CD45-AP*** to p56 ( ***Lck*** ) could take place in the absence of other lymphoid-specific components , suggesting that it can be direct .	parallel	1
2680	10318864	1493;3725	CTLA-4;AP-1	***CTLA-4*** ligation ***suppresses*** CD28-induced NF-kappaB and ***AP-1*** activity in mouse T cell blasts .	negative	1
2681	10318864	1493;4790	CTLA-4;NF-kappaB	***CTLA-4*** ligation ***suppresses*** CD28-induced ***NF-kappaB*** and AP-1 activity in mouse T cell blasts .	negative	1
2682	10318869	9261;6722	MAPKAP kinase 2;serum response factor	***MAPKAP kinase 2*** ***phosphorylates*** ***serum response factor*** in vitro and in vivo .	target	1
2683	10318869	9261;6722	MK2;SRF	***MK2*** ***phosphorylates*** ***SRF*** in vitro at Ser-103 with similar efficiency as the small heat shock protein Hsp25 and significantly better than CREB .	target	1
2684	10318892	8850;595	P/CAF;cyclin D1	***P/CAF*** ***associates*** with ***cyclin D1*** and potentiates its activation of the estrogen receptor .	parallel	0
2685	10318901	3077;7037	HFE;Transferrin receptor	***Transferrin receptor*** is negatively ***modulated*** by the hemochromatosis protein ***HFE*** : implications for cellular iron homeostasis .	negative	0
2686	10318901	3077;7037	HFE;Transferrin receptor	Recent demonstration of an ***association*** between ***Transferrin receptor*** ( TfR ) and ***HFE*** , a major histocompatibility complex class I-like molecule that has been implicated to play a role in hereditary hemochromatosis , further strengthens the notion that HFE is involved in iron metabolism .	parallel	0
2687	10318901	7037;3077	TfR;HFE	Because surface-expressed HFE and TfR remain firmly associated physically , only the fraction of ***TfR*** that is ***associated*** with ***HFE*** during biosynthesis is affected functionally .	parallel	0
2688	10318901	3077;7037	HFE;TfR	Moreover , we show that ***HFE*** binding reduces the number of functional Transferrin binding sites and ***impairs*** ***TfR*** internalization , thus reducing the uptake of Transferrin-bound iron .	negative	0
2689	10318901	3077;7037	HFE;TfR	Thus , iron homeostasis is indirectly regulated by ***HFE*** , a negative ***modulator*** of ***TfR*** .	negative	0
2690	10318904	10049;3308	DnaJ;hsp70	***DnaJ*** ***stimulates*** ***hsp70*** to hydrolyze ATP , a key step that closes its substrate-binding cavity and thus allows stable binding of substrate .	positive	0
2691	10318914	4738;8453	ubiquitin-like protein NEDD8;cullin-2	***Conjugation*** of the ***ubiquitin-like protein NEDD8*** to ***cullin-2*** is linked to von Hippel-Lindau tumor suppressor function .	parallel	1
2692	10318914	4738;7428	ubiquitin-like protein NEDD8;von Hippel-Lindau tumor suppressor	Conjugation of the ***ubiquitin-like protein NEDD8*** to cullin-2 is ***linked*** to ***von Hippel-Lindau tumor suppressor*** function .	parallel	0
2693	10318914	7428;8453	pVHL;cullin-2	The von Hippel-Lindau tumor suppressor protein ***pVHL*** ***assembles*** with ***cullin-2*** ( hCUL-2 ) and elongin B/C forming a protein complex , CBCVHL , that resembles SKP1-CDC53-F-box protein ubiquitin ligases .	parallel	1
2694	10318914	7428;6921	pVHL;elongin B/C	The von Hippel-Lindau tumor suppressor protein ***pVHL*** ***assembles*** with cullin-2 ( hCUL-2 ) and ***elongin B/C*** forming a protein complex , CBCVHL , that resembles SKP1-CDC53-F-box protein ubiquitin ligases .	parallel	1
2695	10318914	4738;8453	ubiquitin-like protein NEDD8;hCUL-2	Here , we show that ***hCUL-2*** is ***modified*** by the conserved ***ubiquitin-like protein NEDD8*** and that NEDD8-hCUL-2 conjugates are part of CBCVHL complexes in vivo .	target	0
2696	10318914	4738;8453	NEDD8;hCUL-2	Thus , ***ligation*** of ***NEDD8*** to ***hCUL-2*** is linked to pVHL activity and may be important for pVHL tumor suppressor function .	parallel	1
2697	10318914	4738;7428	NEDD8;pVHL	Thus , ligation of ***NEDD8*** to hCUL-2 is ***linked*** to ***pVHL*** activity and may be important for pVHL tumor suppressor function .	parallel	0
2698	10318916	1499;595	beta-catenin;cyclin D1	***cyclin D1*** protein levels were ***induced*** by ***beta-catenin*** overexpression and reduced in cells overexpressing the cadherin cytoplasmic domain .	target	1
2699	10318917	3991;2167	HSL;adipocyte lipid-binding protein	By using the yeast two-hybrid system to examine the potential interaction of HSL with other cellular proteins , evidence is provided to demonstrate a direct ***interaction*** of ***HSL*** with ***adipocyte lipid-binding protein*** ( ALBP ) , a member of the family of intracellular lipid-binding proteins that binds fatty acids , retinoids , and other hydrophobic ligands .	parallel	1
2700	10318917	2167;3991	ALBP;HSL	The interaction was demonstrated in vitro by the ***binding*** of ***ALBP*** to ***HSL*** translated in vitro , to HSL in extracts of HSL overexpressing Chinese hamster ovary ( CHO ) cells , and to HSL in extracts of rat adipose tissue .	parallel	1
2701	10318917	2167;3991	ALBP;HSL	The ******HSL-ALBP****** ***interaction*** was mapped to an N-terminal 300-aa region of HSL that is distinct from the C-terminal catalytic domain .	parallel	1
2702	10319191	1557;1559	CYP2C19;CYP2C9	Numerous ***substrates*** and inhibitors of CYP2D6 , ***CYP2C19*** , and ***CYP2C9*** are identified .	parallel	1
2703	10319191	1557;1565	CYP2C19;CYP2D6	Numerous ***substrates*** and inhibitors of ***CYP2D6*** , ***CYP2C19*** , and CYP2C9 are identified .	parallel	1
2704	10319191	1559;1557	CYP2C9;CYP2C19	Numerous ***substrates*** and inhibitors of CYP2D6 , ***CYP2C19*** , and ***CYP2C9*** are identified .	parallel	1
2705	10319191	1559;1565	CYP2C9;CYP2D6	Numerous ***substrates*** and inhibitors of ***CYP2D6*** , CYP2C19 , and ***CYP2C9*** are identified .	parallel	1
2706	10319191	1565;1557	CYP2D6;CYP2C19	Numerous ***substrates*** and inhibitors of ***CYP2D6*** , ***CYP2C19*** , and CYP2C9 are identified .	parallel	1
2707	10319191	1565;1559	CYP2D6;CYP2C9	Numerous ***substrates*** and inhibitors of ***CYP2D6*** , CYP2C19 , and ***CYP2C9*** are identified .	parallel	1
2708	10319265	3135;3133	HLA-G;HLA-E	In addition to the classical MHC class I roles ( antigen presentation and ligation to NK receptors inducing inhibitory and/or activatory signals ) , HLA-G is likely to exert other , novel functions : first , ***HLA-G*** was shown to be involved in the ***control*** of ***HLA-E*** expression by furnishing the appropriate class I leader sequence nonamer peptide ; second , we hypothesize that HLA-G could be a regulator of placental angiogenesis ; third , soluble HLA-G isoforms may act as specific immunosuppressors during pregnancy .	target	0
2709	10319275	3308;5610	HSP70;PKR	This variation in the ***induction*** of 2-5A and ***PKR*** by ***anti-HSP70*** or IFN-beta indicates involvement of IFN-beta in viral induction 2-5A and PKR , and HSP involvement in chemical induction of these enzymes .	target	1
2710	10319275	3456;5610	IFN-beta;PKR	This variation in the ***induction*** of 2-5A and ***PKR*** by anti-HSP70 or ***IFN-beta*** indicates involvement of IFN-beta in viral induction 2-5A and PKR , and HSP involvement in chemical induction of these enzymes .	target	1
2711	10319320	7422;3791	VEGF;Flk-1	The ***VEGF-induced*** tyrosine ***phosphorylation*** of the VEGF receptor , ***Flk-1*** , and its association with the Shc/Grb2/Ras-GAP ( guanosine triphosphatase-activating protein ) complex were unaffected by 16K hPRL treatment .	target	1
2712	10319320	3791;7422	Flk-1;VEGF	The VEGF-induced tyrosine phosphorylation of the ***VEGF*** ***receptor*** , ***Flk-1*** , and its association with the Shc/Grb2/Ras-GAP ( guanosine triphosphatase-activating protein ) complex were unaffected by 16K hPRL treatment .	parallel	1
2713	10319323	2516;1051	SF-1;C/EBP beta	***SF-1*** ( steroidogenic factor-1 ) and ***C/EBP beta*** ( CCAAT/enhancer binding protein-beta ) ***cooperate*** to regulate the murine StAR ( steroidogenic acute regulatory ) promoter .	parallel	0
2714	10319324	5449;2353	GHF-1;c-fos	The tissue-specific transcription factor ***Pit-1/GHF-1*** ***binds*** to the ***c-fos*** serum response element and activates c-fos transcription .	parallel	1
2715	10319324	5449;2353	GHF-1;c-fos	The tissue-specific transcription factor ***Pit-1/GHF-1*** binds to the c-fos serum response element and ***activates*** ***c-fos*** transcription .	positive	1
2716	10319324	5449;2353	Pit-1;c-fos	We show that ***Pit-1*** overexpression in PC12 cells , which do not express Pit-1 , ***increases*** ***c-fos*** expression .	positive	0
2717	10319325	2796;1958	GnRH;Egr1	Thus , ***GnRH*** ***induces*** expression of ***Egr1*** , which subsequently activates the eLH beta promoter .	target	1
2718	10319326	2101;2516	ERR alpha;SF-1	We show that ***ERR alpha*** ***binds*** as a homodimer on a specific target sequence , the SFRE ( ***SF-1*** response element ) , already known to respond to the orphan nuclear receptor SF-1 .	parallel	1
2719	10319327	6722;2353	SRF;c-fos	The ***SRF*** and bHLH proteins appear to bind to the SRE and ***activate*** the ***c-fos*** promoter in Sertoli cells .	positive	1
2720	10319586	10401;6774	PIAS3;STAT3	Mouse ***PIAS3*** ( protein inhibitor of activated STAT3 ) is a specific ***inhibitor*** of ***STAT3*** that downregulates its signaling pathway .	negative	1
2721	10319863	8915;4790	BCL10;NF-kappaB	Wild-type ***BCL10*** ***activated*** ***NF-kappaB*** but induced apoptosis of MCF7 and 293 cells .	positive	1
2722	10319864	7039;1956	transforming growth factor-alpha;Epidermal growth factor receptor	Cleft lip and palate syndromes in humans are associated with polymorphisms in the gene ( TGFA ) encoding ***transforming growth factor-alpha*** ( TGF-alpha ) , an ***Epidermal growth factor receptor*** ( Egfr ) ***ligand*** made by most epithelia .	parallel	1
2723	10319872	4609;6598	c-MYC;INI1	***c-MYC*** ***interacts*** with ***INI1/hSNF5*** and requires the SWI/SNF complex for transactivation function .	parallel	1
2724	10319872	4609;6594	c-MYC;SWI	***c-MYC*** interacts with INI1/hSNF5 and ***requires*** the ***SWI/SNF*** complex for transactivation function .	target	0
2725	10319872	4609;6598	c-MYC;INI1	The ******c-MYC-INI1****** ***interaction*** was observed both in vitro and in vivo .	parallel	1
2726	10319872	4609;6598	c-MYC;INI1	Our results suggest that the SWI/SNF complex is necessary for c-MYC-mediated transactivation and that the ******c-MYC-INI1****** ***interaction*** helps recruit the complex .	parallel	1
2727	10319992	4609;1026	c-Myc;p21	We show here that exogenous ***c-Myc*** ***inhibits*** ***p21*** expression in SkBr3 and LNCaP cells induced to enter into S-phase .	negative	1
2728	10319992	4609;1026	c-Myc;p21	Overexpression of c-Myc reduced the levels of endogenous p21 mRNA , and transfection of ***c-Myc*** ***repressed*** ***p21-promoter*** luciferase-reporter gene expression .	negative	1
2729	10320001	351;3329	beta-amyloid peptide;hsp60	In contrast , treatment with the Alzheimer 's toxin , the ***beta-amyloid peptide*** , ***reduced*** the amount of intracellular ***hsp60*** .	negative	1
2730	10320009	5020;5443	Oxytocin;ACTH	The aim of this study was to investigate how ***Oxytocin*** ( OXT ) ***influences*** plasma levels of ***ACTH*** and corticosterone in rats .	target	0
2731	10320030	2185;627	protein kinase B;brain-derived neurotrophic factor	Sustained phosphorylation and activation of ***protein kinase B*** ***correlates*** with ***brain-derived neurotrophic factor*** and insulin stimulated survival of cerebellar granule cells .	parallel	0
2732	10320322	998;207	Cdc42;Rac	Most of the putative effectors for the Rho-family small GTPases Cdc42 and Rac share a common sequence motif referred to as the ******Cdc42/Rac****** interactive ***binding*** ( CRIB ) motif .	parallel	1
2733	10320322	5062;998	PAK2;Cdc42	***Interaction*** of the 22-residue peptide ***PAK2*** ( 71-92 ) with GTP-gammaS-loaded ***Cdc42*** causes resonance perturbations in the 1H-15N HSQC spectrum of Cdc42 that are similar to those observed for a longer ( 46-amino acid ) CRIB-containing protein fragment [ Guo , W. , et al. ( 1998 ) Biochemistry 37 , 14030-14037 ] .	parallel	1
2734	10320352	4792;3551	IkappaBalpha;IKK2	We have studied the direct ***interaction*** of recombinant ***IkappaBalpha*** , IkappaBbeta1 , IkappaBbeta2 , and IkappaBepsilon with the recombinant homodimeric ***IKK2*** .	parallel	1
2735	10320352	4794;3551	IkappaBepsilon;IKK2	We have studied the direct ***interaction*** of recombinant IkappaBalpha , IkappaBbeta1 , IkappaBbeta2 , and ***IkappaBepsilon*** with the recombinant homodimeric ***IKK2*** .	parallel	1
2736	10320373	3439;7297	IFN-alpha;Tyk2	***Activation*** of ***Tyk2*** in NK cells by ***IFN-alpha/beta*** also required NOS2 .	positive	1
2737	10320482	650;3549	BMP-2;Ihh	We also showed that retrovirally induced ***BMP-2*** ***induces*** the expression of both ***Ihh*** and noggin ( encoding the BMP-inactivating protein ) , and we further present evidence that a negative-feedback loop involving noggin might account for the precise localization of BMP signalling for Ihh induction .	target	1
2738	10320482	650;9241	BMP-2;noggin	We also showed that retrovirally induced ***BMP-2*** ***induces*** the expression of both Ihh and ***noggin*** ( encoding the BMP-inactivating protein ) , and we further present evidence that a negative-feedback loop involving noggin might account for the precise localization of BMP signalling for Ihh induction .	target	1
2739	10320483	9564;5792	p130Cas;LAR	CONCLUSIONS : ***p130Cas*** is an in vivo ***substrate*** of ***LAR*** .	parallel	1
2740	10320483	5792;9564	LAR;p130Cas	***LAR*** specifically ***dephosphorylates*** and destabilizes ***p130Cas*** and may play a role in regulating cell adhesion-mediated cell survival .	target	1
2741	10320526	5741;2247	PTH;FGF-2	We conclude that ***PTH*** and cAMP ***stimulate*** ***FGF-2*** mRNA abundance in part through a transcriptional mechanism .	positive	0
2742	10320526	2247;5741	FGF-2;PTH	We hypothesize that some effects of ***PTH*** on bone remodeling may be ***mediated*** by regulation of ***FGF-2*** and FGFR expression in osteoblastic cells .	target	0
2743	10320526	5741;2247	Parathyroid hormone;fibroblast growth factor-2	***Parathyroid hormone*** ***regulates*** the expression of ***fibroblast growth factor-2*** mRNA and fibroblast growth factor receptor mRNA in osteoblastic cells .	target	1
2744	10320526	5741;2263	PTH;FGFR-2	***PTH*** also increased FGFR-1 mRNA at 2 h and transiently ***increased*** ***FGFR-2*** mRNA at 1 h.	positive	0
2745	10320526	5741;2247	PTH;FGF-2	Immunohistochemistry showed that ***PTH*** and FSK ***increased*** ***FGF-2*** protein labeling in the nuclei of MC3T3-E1 cells .	positive	0
2746	10320526	5741;2247	PTH;FGF-2	***PTH*** also ***increased*** ***FGF-2*** mRNA , and FGFR-1 and FGFR-2 mRNA levels within 30 minutes in neonatal mouse calvarial organ cultures .	positive	0
2747	10320562	7040;5617	TGF-beta1;prolactin	However , in the short term ( up to 12 h ) ***TGF-beta1*** ***inhibition*** of ***prolactin*** secretion was associated with an increase in intracellular prolactin content , dissecting a dual mechanism of action of TGF-beta1 .	negative	1
2748	10320562	7040;5617	TGF-beta1;prolactin	However , pertussis toxin was able to recover a large percentage of ***TGF-beta1-induced*** ***inhibition*** of ***prolactin*** secretion .	negative	1
2749	10320562	7040;5617	TGF-beta1;prolactin	This study characterized the ***regulation*** of in-vitro ***prolactin*** synthesis and secretion by ***TGF-beta1*** using rat anterior pituitary cells in monolayer culture .	target	1
2750	10320562	7040;5617	TGF-beta1;prolactin	***TGF-beta1*** ***inhibited*** ***prolactin*** secretion in a time - and concentration-dependent manner , with half-maximal inhibition occurring at the range of 15-30 pM .	negative	1
2751	10320562	7040;5617	TGF-beta1;prolactin	The effect observed after long-term treatment ( 24 h to 4 days ) is essentially caused by a decrease in prolactin synthesis , since ***TGF-beta1*** ***inhibited*** ***prolactin*** mRNA levels and de novo prolactin protein synthesis .	negative	1
2752	10320618	3586;3458	IL-10;IFNgamma	We studied the role of the Th2 cytokine IL-10 during leishmania infection : removal of endogenous ***IL-10*** by anti-IL-10 treatment did not alter the Th2 cytokine pattern in non-healer mice nor did it modulate DTH reactivity , IgE production or fatal disease progression , but partially ***blocked*** the ***IFNgamma*** inhibiting effect of rIL-4 in healer mice .	positive	0
2753	10320637	3821;3824	NKG2A;CD94	We show that soluble ***NKG2A*** , - B and - C lectin domains ***interact*** with ***CD94*** lectin domains to form complexes , whereas NKG2D and human NKR-P1 lectin domains do not .	parallel	1
2754	10320638	811;6737	calreticulin;SS-A	***calreticulin*** also ***binds*** to the ***Ro/SS-A*** antigen complex , which is composed of at least three immunologically distinct proteins bound to a group of small cytoplasmic RNAs that together form a common target for autoimmune responses .	parallel	1
2755	10320641	3458;3075	interferon-gamma;complement factor H	***Regulation*** of ***complement factor H*** in a human liver cell line by ***interferon-gamma*** .	target	1
2756	10320641	3458;3075	IFN-gamma;factor H	Thus ***induction*** of ***factor H*** by ***IFN-gamma*** apparently involves two factors .	target	1
2757	10320721	2922;5443	gastrin-releasing peptide;adrenocorticotropin	Hypothalamus , anterior pituitary and adrenal gland involvement in the ***activation*** of ***adrenocorticotropin*** and corticosterone secretion by ***gastrin-releasing peptide*** .	positive	1
2758	10320721	2922;5443	GRP;ACTH	In addition , in dispersed anterior pituitary cells which medium contained Ca2 + ( 1.5 mM ) , ***GRP*** ***stimulated*** the secretion of ***ACTH*** , but was without effect when the concentration of Ca2 + in the medium was lower ( 200 nM ) .	positive	0
2759	10320721	2922;5443	GRP;ACTH	These results suggest that : ( 1 ) the hypothalamus , anterior pituitary and adrenal gland seem to contribute to the elevation of ACTH and corticosterone secretion induced by GRP by a mechanism mediated through GRP receptors and ( 2 ) the ***stimulation*** of ***ACTH*** by ***GRP*** in the anterior pituitary appears to be dependent upon the presence of physiological concentrations of extracellular Ca2 + .	positive	0
2760	10320778	627;4915	BDNF;trkB	Previous work had shown that during early ( prenatal ) development , ***trkB*** and its two ***ligands*** , ***BDNF*** and NT-4/5 , were most important for survival of almost all neurons .	parallel	1
2761	10320778	4909;4915	NT-4/5;trkB	Previous work had shown that during early ( prenatal ) development , ***trkB*** and its two ***ligands*** , BDNF and ***NT-4/5*** , were most important for survival of almost all neurons .	parallel	1
2762	10320804	5320;22925	sPLA2;PLA2R	Group IB ***sPLA2*** ( PLA2-IB ) ***binds*** to the PLA2 receptor ( ***PLA2R*** ) , and PLA2R-deficient mice exhibit resistance to endotoxin-induced lethality with reduced plasma levels of proinflammatory cytokines , such as TNF-alpha .	parallel	1
2763	10320804	22925;5319	PLA2R;PLA2	Group IB sPLA2 ( PLA2-IB ) binds to the ***PLA2*** ***receptor*** ( ***PLA2R*** ) , and PLA2R-deficient mice exhibit resistance to endotoxin-induced lethality with reduced plasma levels of proinflammatory cytokines , such as TNF-alpha .	parallel	1
2764	10320804	5319;22925	PLA2;PLA2R	Indoxam was found to block the ***PLA2-IB*** ***binding*** to murine ***PLA2R*** with a high potency ( Ki = 30 nM ) .	parallel	1
2765	10321529	7048;7040	TbetaR-II;TGF-beta	The type II receptors examined were ***TGF-beta*** type II ***receptor*** ( ***TbetaR-II*** ) , activin type II receptor ( ActR-II ) , and BMP type II receptor ( BMPR-II ) .	parallel	1
2766	10321688	4084;7157	Mad;p53	***Mad-overexpression*** down ***regulates*** the malignant growth and ***p53*** mediated apoptosis in human hepatocellular carcinoma BEL-7404 cells .	target	1
2767	10321724	5020;359	oxytocin;aquaporin-2	Administration of ***oxytocin*** ***affects*** vasopressin V2 receptor and ***aquaporin-2*** gene expression in the rat .	target	0
2768	10321724	5020;554	oxytocin;V2R	***oxytocin*** ( OT ) ***binds*** to the vasopressin V2 receptor ( ***V2R*** ) because of its structural similarity to arginine vasopressin ( AVP ) .	parallel	1
2769	10321728	5071;1499	E3 ubiquitin ligase;beta-catenin	These results demonstrate that SCF ( HOS ) ***E3 ubiquitin ligase*** ***regulate*** both NF-kappaB and ***beta-catenin*** signaling pathways .	target	1
2770	10321728	5071;4790	E3 ubiquitin ligase;NF-kappaB	These results demonstrate that SCF ( HOS ) ***E3 ubiquitin ligase*** ***regulate*** both ***NF-kappaB*** and beta-catenin signaling pathways .	target	1
2771	10321733	5926;5934	RBP1;p130	We show here that ***RBP1*** , a known pRB pocket-binding protein , possesses transcriptional repression activity and ***associates*** with ***p130-E2F*** and pRB-E2F complexes specifically during growth arrest .	parallel	0
2772	10321733	5926;5925	RBP1;pRB	We show here that ***RBP1*** , a known pRB pocket-binding protein , possesses transcriptional repression activity and ***associates*** with p130-E2F and ***pRB-E2F*** complexes specifically during growth arrest .	parallel	0
2773	10321734	4193;7161	mdm2;p73	***Inactivation*** of the p53-homologue ***p73*** by the ***mdm2-oncoprotein*** .	negative	1
2774	10321734	4193;7157	mdm2;p53	Complex ***formation*** between ***p53*** and ***mdm2*** results in p53 's transcriptional inactivation and destabilization .	parallel	0
2775	10321735	22800;5599	TC21;JNK	Thus , like Ras , ***TC21*** may ***activate*** a ***Rac/JNK*** pathway .	positive	1
2776	10321735	22800;5599	TC21;JNK	Second , we found that ***TC21*** is an ***activator*** of the ***JNK*** and p38 , but not ERK , mitogen-activated protein kinase cascades and that TC21 transforming activity was dependent on Rac function .	positive	1
2777	10321735	22800;5594	TC21;p38	Second , we found that ***TC21*** is an ***activator*** of the JNK and ***p38*** , but not ERK , mitogen-activated protein kinase cascades and that TC21 transforming activity was dependent on Rac function .	positive	1
2778	10321737	3659;1026	IRF-1;p21	***Activation*** and repression of the 2-5A synthetase and ***p21*** gene promoters by ***IRF-1*** and IRF-2 .	positive	1
2779	10321737	3660;1026	IRF-2;p21	***Activation*** and repression of the 2-5A synthetase and ***p21*** gene promoters by IRF-1 and ***IRF-2*** .	positive	1
2780	10321737	3659;1026	IRF-1;p21	Following ectopic expression , ***IRF-1*** ***transactivated*** 2-5A synthetase and ***p21*** genes , an effect that was counterbalanced by concomitant ectopic expression of IRF-2 .	positive	1
2781	10321737	3659;3660	IRF-1;IRF-2	***IRF-1*** also ***induced*** expression of its homologous repressor ***IRF-2*** as indicated by EMSA analysis using an IRF-E probe from the IRF-2 promoter ; and by cotransfection of IRF-1 together with an IRF-2 promoter CAT construct .	target	1
2782	10321759	3557;7124	interleukin-1 receptor antagonist;TNF alpha	AIMS : To determine potential ***associations*** of ***interleukin-1 receptor antagonist*** ( IL-1ra ) , tumour necrosis factor alpha ( ***TNF alpha*** ) , and tumour necrosis factor beta ( TNF beta ) gene polymorphisms with ulcerative colitis or subsets of ulcerative colitis in a Spanish population .	parallel	0
2783	10322110	4654;4205	MyoD;MEF2	Without pRb , ***MyoD*** ***induces*** the accumulation of nuclear-localized ***MEF2*** that is competent to bind DNA yet transcriptionally inert .	target	1
2784	10322110	4654;4208	MyoD;MEF2C	When pRb is present , ***MyoD*** ***stimulates*** the function of the ***MEF2C*** transcriptional activation domain and the activity of endogenous MEF2-type factors .	positive	0
2785	10322114	2130;2185	EWS;Pyk2	Here , we show that ***EWS*** ***interacts*** with ***Pyk2*** , a protein tyrosine kinase implicated in a variety of signal transduction processes .	parallel	1
2786	10322114	2185;2130	Pyk2;EWS	G-protein-coupled receptor signaling and other stimuli of Pyk2 kinase activity significantly block the ***interaction*** between ***EWS*** and ***Pyk2*** .	parallel	1
2787	10322116	351;4137	beta-amyloid peptide;Tau	Although several groups have reported physical interaction between APP and Tau , and ***induction*** of ***Tau*** phosphorylation by APP and ***beta-amyloid peptide*** , the functional connection between APP and Tau is unclear .	target	1
2788	10322116	351;4137	APP;Tau	Although several groups have reported physical ***interaction*** between ***APP*** and ***Tau*** , and induction of Tau phosphorylation by APP and beta-amyloid peptide , the functional connection between APP and Tau is unclear .	parallel	1
2789	10322638	5310;1499	polycystin-1;beta-catenin	***polycystin-1*** is highly expressed in the ureteric bud and other branching epithelia during development and ***interacts*** with ***beta-catenin*** , a molecule known to play a role in branching morphogenesis .	parallel	1
2790	10322639	554;551	V2R;arginine vasopressin	Concentration of urine requires : 1 ) medullary collecting ducts ( CD ) located within a hypertonic interstitium , 2 ) CD cell expression of functional ***arginine vasopressin*** V2 ***receptors*** ( ***AVP-V2R*** ) , and 3 ) the presence of appropriate CD water channels ( aquaporins , AQP 2 and 3 ) .	parallel	1
2791	10322639	551;359	AVP;AQP2	***AVP*** ***upregulates*** the expression of AVP-V2R , ***AQP2*** , and AQP3 mRNAs in vitro .	positive	1
2792	10322639	551;360	AVP;AQP3	***AVP*** ***upregulates*** the expression of AVP-V2R , AQP2 , and ***AQP3*** mRNAs in vitro .	positive	1
2793	10322639	551;554	AVP;V2R	***AVP*** ***upregulates*** the expression of ***AVP-V2R*** , AQP2 , and AQP3 mRNAs in vitro .	positive	1
2794	10322947	6750;2353	somatostatin;c-fos	[ ***somatostatin*** and electroacupuncture ***inhibited*** ***c-fos*** expression in spinal cord of arthritic rats ] .	negative	1
2795	10323452	3596;3605	IL-13;IL-17	Addition of both IL-4 and ***IL-13*** completely ***inhibited*** the production of ***IL-17*** , whereas IL-10 had no effect .	negative	1
2796	10323452	3565;3605	IL-4;IL-17	Addition of both ***IL-4*** and IL-13 completely ***inhibited*** the production of ***IL-17*** , whereas IL-10 had no effect .	negative	1
2797	10323670	2099;4846	ERalpha;eNOS	These findings indicate that the acute effects of estrogen on both endothelial and airway epithelial ***eNOS*** are ***mediated*** by ***ERalpha*** functioning in a novel , nongenomic manner to activate the enzyme via calcium-dependent , MAP kinase-dependent mechanisms .	target	0
2798	10323791	5054;7040	PAI-1;TGF-beta	***PAI-1*** production by adipose tissue was ***correlated*** with those of TNF-alpha ( r = 0.5 , P = 0.01 ) and ***TGF-beta*** ( r = 0 .	parallel	0
2799	10323868	1017;5715	Cdk2;p27	Furthermore , another p27 mutant [ ***p27*** ( CK - ) ] that can be ***phosphorylated*** by cyclin ***E/Cdk2*** but can not bind this kinase complex , is refractory to ubiquitination .	target	1
2800	10323868	983;5715	Cdk1;p27	In fact , cyclin ***B/Cdk1*** which can ***phosphorylate*** ***p27*** efficiently , but can not form a stable complex with it , is unable to stimulate p27 ubiquitination by G1 extracts .	target	1
2801	10325225	2475;10243	RAFT1;gephyrin	***Interaction*** of ***RAFT1*** with ***gephyrin*** required for rapamycin-sensitive signaling .	parallel	1
2802	10325225	2475;10243	RAFT1;gephyrin	In mammalian cells ***RAFT1*** ***interacted*** with ***gephyrin*** , a widely expressed protein necessary for the clustering of glycine receptors at the cell membrane of neurons .	parallel	1
2803	10325244	183;5972	angiotensinogen;renin	To test whether prorenin might be enzymatically active in these tissues , transgenic mice expressing the human ***renin*** ***substrate*** ( ***angiotensinogen*** ) exclusively in the pituitary gland were mated to mice expressing either active human renin or prorenin in the same tissue .	parallel	1
2804	10325245	183;1956	Angiotensin II;epidermal growth factor receptor	***Angiotensin II-induced*** ***transactivation*** of ***epidermal growth factor receptor*** regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms .	positive	1
2805	10325245	2353;3725	c-fos;c-jun	We concluded that Ang II-induced expression of fibronectin and TGF-beta is mediated by downstream signaling of EGF-R transactivated by Ca2 + - dependent tyrosine kinase and that Ang II-induced fibronectin mRNA expression is regulated by 2 different mechanisms , which are transcriptional control by binding of the ******c-fos/c-jun****** ***complex*** to the AP-1 site and posttranscriptional control by mRNA stabilization due to autocrine or paracrine effects of TGF-beta .	parallel	1
2806	10325247	5970;4790	p65;p50	The mobility of the NF-kappaB DNA complex was shifted by anti-p65 and anti-p50 antibodies but not by anti-c-Rel antibodies , indicating that the subunits of NF-kappaB involved in gene activation after ischemic PC consist of ******p65-p50****** ***heterodimers*** .	parallel	1
2807	10325253	213;7422	albumin;vascular endothelial growth factor	Human ***albumin*** ***enhances*** expression of ***vascular endothelial growth factor*** in cultured human luteinizing granulosa cells : importance in ovarian hyperstimulation syndrome .	positive	0
2808	10325253	213;7422	albumin;VEGF	Here it is reported that in cultured human luteinizing granulosa cells , ***VEGF*** mRNA expression was ***enhanced*** by human ***albumin*** and maximum expression was observed in cultured granulosa cells obtained from patients with serum oestradiol concentrations > 2000 pg/ml on the day of human chorionic gonadotrophin injection ( P < 0 .	positive	0
2809	10326621	7042;920	transforming growth factor (TGF)-beta 2;CD4	Because ***transforming growth factor (TGF)-beta 2*** ***down-regulates*** ***CD4*** membrane expression , its contribution , as well as the contribution of TGF-beta 1 and prostaglandin ( PG ) E2 , to the modulation CD8 expression was studied using human peripheral blood lymphocytes ( PBLs ) .	negative	1
2810	10326761	7980;2159	TFPI-2;factor Xa	However , whereas wild-type ***TFPI-2*** is a relatively weak ***inhibitor*** of human ***factor Xa*** amidolytic activity ( IC50 approximately 1 microM ) , R24Q TFPI-2 exhibited enhanced inhibitory activity towards the amidolytic and coagulant activities of this proteinase with a Ki of 18 nM .	negative	1
2811	10326761	7980;2159	TFPI-2;factor Xa	While the molecular basis for the enhanced ***inhibition*** of human ***factor Xa*** by R24Q ***TFPI-2*** is unknown , these data provide suggestive evidence that murine TFPI-2 may function as a serine proteinase inhibitor in spite of the absence of a P1 Arg or Lys residue .	negative	1
2812	10326762	4018;4043	lipoprotein;39-kDa receptor associated protein	Low density ***lipoprotein*** receptor family members characteristically ***bind*** ***39-kDa receptor associated protein*** ( RAP ) .	parallel	1
2813	10326865	7422;3791	VEGF;VEGFR	Moreover , overexpression of ***VEGF*** was ***related*** to upregulation of ***VEGFR-1*** / Flt-1 and VEGFR-2 / Flk-1 expression in malignant and premalignant lung lesions .	parallel	0
2814	10327051	2033;3725	p300;c-jun	The N-terminal transactivation domain of ATF2 is a target for the co-operative ***activation*** of the ***c-jun*** promoter by ***p300*** and 12S E1A .	positive	1
2815	10327051	2033;3725	p300;AP1	***p300*** , a transcriptional ***coactivator*** of several ***AP1*** and ATF transcription factors has been postulated to play a role in this activation .	positive	1
2816	10327051	2033;2668	p300;ATF	***p300*** , a transcriptional ***coactivator*** of several AP1 and ***ATF*** transcription factors has been postulated to play a role in this activation .	positive	1
2817	10327051	2033;3725	p300;c-jun	Here , we present evidence that p300 can control c-jun transcription by acting as a cofactor for ATF2 : ( 1 ) Over-expression of ***p300*** was found to ***stimulate*** ***c-jun*** transcription both in the presence and absence of E1A .	positive	0
2818	10327051	2033;3725	p300;c-jun	Here , we present evidence that ***p300*** can ***control*** ***c-jun*** transcription by acting as a cofactor for ATF2 : ( 1 ) Over-expression of p300 was found to stimulate c-jun transcription both in the presence and absence of E1A .	target	0
2819	10327051	1387;2033	CBP;p300	We further demonstrate that the Stress-Activated-Protein-Kinase ( SAPK ) target sites of ATF2 , Thr69 and Thr71 are not required for the formation of the ******p300/CBP-GeneGene****** 3 multiprotein ***complex*** .	parallel	1
2820	10327058	7157;1026	p53;WAF1	We employ a tet-repressible system to show that , under conditions in which the ***WAF1*** mRNA steady-state level is ***upregulated*** fourfold by ***p53*** , the SCL mRNA level is not altered .	positive	1
2821	10327058	7157;6886	p53;SCL	This disparity prompted us to explore the differences between ***p53*** ***regulation*** of ***SCL*** CS activity in organized ( chromosomally integrated ) and disorganized ( non-replicating episomal plasmid ) chromatin .	target	1
2822	10327062	4193;7157	mdm-2;p53	In contrast to the Q22 , S23 double mutation , this latter mutation set does not alter ***mdm-2-mediated*** ***inhibition*** and degradation of ***p53*** .	negative	1
2823	10327073	3195;1489	HOX11;CTF1	***HOX11*** ***interacts*** with ***CTF1*** and mediates hematopoietic precursor cell immortalization .	parallel	1
2824	10327200	8851;1020	p35;cyclin-dependent kinase 5	Expression of ***cyclin-dependent kinase 5*** and its ***activator*** ***p35*** in rat brain after middle cerebral artery occlusion .	positive	1
2825	10328178	1437;3383	CSF;ICAM-1	Administration of ***rG-CSF*** prior to LPS exposure tended to ***increase*** NOS II , CINC , and ***ICAM-1*** mRNA transcripts in hepatocytes .	positive	0
2826	10328232	356;355	FasL;CD95	***CD95/APO-1*** ***ligand*** ( ***FasL*** ) is implicated in the maintenance of immune privileged sites by inducing apoptosis of activated infiltrating T lymphocytes .	parallel	1
2827	10328545	7157;1026	p53;p21	The Cdk inhibitor ***p21/WAF1*** can be transcriptionally ***activated*** by wild-type ***p53*** , not by mutant p53 , and functions to block cell-cycle progression in many human neoplasms .	positive	1
2828	10328578	356;355	hFasL;Fas	Employing these molecular processes in the treatment of RA , we have recently shown that ex vivo gene transfer of human ***Fas*** ***ligand*** ( ***hFasL*** ) induced apoptosis of synoviocytes and infiltrated mononuclear cells of RA synovial tissue through cell-to-cell interaction via the Fas/FasL system .	parallel	1
2829	10328873	3565;3569	interleukin 4;interleukin 6	***Interactions*** of noradrenalin and tumour necrosis factor alpha , ***interleukin 4*** and ***interleukin 6*** in the control of lipolysis from adipocytes around lymph nodes .	parallel	1
2830	10328918	9241;3549	Noggin;Ihh	***Interaction*** of ***Ihh*** and ***BMP/Noggin*** signaling during cartilage differentiation .	parallel	1
2831	10328918	3549;650	Indian hedgehog;BMP2	We further demonstrate that misexpression of ***Indian hedgehog*** appears to directly ***upregulate*** ***BMP2*** and BMP4 expression , independent of the differentiation state of the flanking chondrocytes .	positive	1
2832	10328918	3549;652	Indian hedgehog;BMP4	We further demonstrate that misexpression of ***Indian hedgehog*** appears to directly ***upregulate*** BMP2 and ***BMP4*** expression , independent of the differentiation state of the flanking chondrocytes .	positive	1
2833	10328953	375790;2247	agrin;FGF-2	Our data show that ***agrin*** ***binds*** ***FGF-2*** and thrombospondin by a heparan sulfate-dependent mechanism , merosin and laminin by both heparan sulfate-dependent and - independent mechanisms , and tenascin solely via agrin 's protein core .	parallel	1
2834	10328964	2247;4656	bFGF;myogenin	These results indicate that both TNF-alpha and ***bFGF*** ***inhibit*** ***myogenin*** expression but differentially influence myoblast proliferation .	negative	1
2835	10328964	7124;4656	TNF-alpha;myogenin	These results indicate that both ***TNF-alpha*** and bFGF ***inhibit*** ***myogenin*** expression but differentially influence myoblast proliferation .	negative	1
2836	10328964	7124;3479	TNF-alpha;IGF-I	We have examined the mechanisms by which ***TNF-alpha*** , in comparison to basic fibroblast growth factor ( bFGF ) , ***inhibits*** the insulin-like growth factor-I ( ***IGF-I*** ) - induced differentiation of C2C12 myoblasts .	negative	1
2837	10328964	7124;4656	TNF-alpha;myogenin	However , ***TNF-alpha*** ***inhibited*** ***myogenin*** mRNA and protein expression .	negative	1
2838	10329108	5595;5594	ERK-1;ERK	Phospho-specific ***ERK-1*** and ERK-2 mitogen-activated protein kinase ( MAPK ) antibody , which ***recognizes*** only activated ***ERK*** , was used to determine ERK activation status by Western blotting .	target	1
2839	10329190	5450;5451	Bob1;Oct-1	The expression of immunoglobulin genes is controlled in part by the DNA-binding protein ***Oct-1*** and the B cell-specific transcription co-activator , ***Bob1*** ( also known as OCA-B or OBF-1 ) that together form a ***complex*** on the Igkappa promoter .	parallel	1
2840	10329351	7124;5321	TNF-alpha;cPLA2	***TNF-alpha*** also ***increased*** the level of immunoreactive ***cPLA2*** protein in a time-dependent manner with the highest levels evident after 8 and 16 h.	positive	0
2841	10329371	2934;351	gelsolin;Abeta	We report here that ***gelsolin*** , a secretory protein , also ***binds*** to ***Abeta*** in a concentration-dependent manner .	parallel	1
2842	10329371	2934;351	gelsolin;Abeta	Abeta was found to co-immunoprecipitate along with gelsolin from the plasma , suggesting that ******gelsolin-Abeta****** ***complex*** exists under physiological conditions .	parallel	1
2843	10329371	2934;351	gelsolin;Abeta	The ******gelsolin-Abeta****** ***complex*** was sodium dodecyl sulfate ( SDS ) stable in the absence of reducing agent , but was dissociated when the SDS stop solution contained dithiothreitol ( reducing agent ) .	parallel	1
2844	10329371	2934;351	gelsolin;Abeta	This study suggests that the function of secretory ***gelsolin*** in the CSF and plasma is to ***bind*** and sequester ***Abeta*** .	parallel	1
2845	10329376	2885;6464	Grb2;Shc	It is also suggested that the phosphorylated p58 xShc may play a role unique to the egg activation process because we found that there was no increase of ******Shc-Grb2****** ***complex*** after fertilization .	parallel	1
2846	10329379	5617;672	Prolactin;BRCA1	***Prolactin-dependent*** ***up-regulation*** of ***BRCA1*** expression in human breast cancer cell lines .	positive	1
2847	10329393	4086;652	Smad1;BMP-4	Human , Drosophila , and Xenopus ***Smad1*** all have been shown to ***mediate*** the biological effects of ***BMP-4*** in Xenopus embryos .	target	0
2848	10329396	10307;351	Fe65L2;beta-amyloid precursor protein	Genome structure and chromosomal mapping of the gene for ***Fe65L2*** ***interacting*** with Alzheimer 's ***beta-amyloid precursor protein*** .	parallel	1
2849	10329396	10307;351	Fe65L2;beta-amyloid precursor protein	Recently we cloned the cDNA encoding human ***Fe65L2*** , which ***interacts*** with Alzheimer 's ***beta-amyloid precursor protein*** ( APP ) .	parallel	1
2850	10329404	7124;5054	Tumor necrosis factor alpha;PAI-1	***Tumor necrosis factor alpha*** ( TNF-alpha ) ***enhanced*** ***PAI-1*** secretion and mRNA expression by approximately 2-fold .	positive	0
2851	10329404	5468;5054	PPARgamma;PAI-1	These results suggest that ***PPARgamma*** may ***regulate*** ***PAI-1*** expression in HUVEC and that thiazolidinediones have a therapeutic potential for improving endothelial dysfunction observed in insulin resistance .	target	1
2852	10329406	7124;1432	tumor necrosis factor-alpha;p38 MAP kinase	Thioredoxin negatively regulates ***p38 MAP kinase*** ***activation*** and IL-6 production by ***tumor necrosis factor-alpha*** .	positive	1
2853	10329406	7295;1432	TRX;p38 MAP kinase	The results showed that TNF-alpha-induced ***p38 MAP kinase*** ***activation*** and interleukin-6 ( IL-6 ) production by ***TRX*** 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 ) .	positive	1
2854	10329406	1432;3569	p38 MAP kinase;IL-6	SB 203580 as the specific inhibitor for p38 MAP kinase activity inhibited TNF-alpha-induced IL-6 production by the parental L cells , indicating that TNF-alpha-activated ***p38 MAP kinase*** ***regulates*** ***IL-6*** production by the cell lines used in this study .	target	1
2855	10329406	7295;3569	TRX;IL-6	These results showed that overexpression of ***TRX*** negatively ***regulates*** p38 MAP kinase activation and p38 MAP kinase-mediated ***IL-6*** production by TNF-alpha-stimulated cells , indicating that TRX is critical for p38 MAP kinase activation which regulates cytokine expression .	negative	1
2856	10329406	7295;1432	TRX;p38 MAP kinase	These results showed that overexpression of ***TRX*** negatively ***regulates*** ***p38 MAP kinase*** activation and p38 MAP kinase-mediated IL-6 production by TNF-alpha-stimulated cells , indicating that TRX is critical for p38 MAP kinase activation which regulates cytokine expression .	negative	1
2857	10329410	5468;7352	PPARgamma;UCP3	Moreover , BRL49653 , a ligand for the nuclear hormone receptor PPARgamma induces expression of UCP3 mRNA suggesting that ***PPARgamma*** may ***regulate*** transcription of the ***UCP3*** gene .	target	1
2858	10329423	3931;57338	LCAT;HDL2	In this study the equilibrium dissociation constants ( Kds ) for the ***interaction*** of pure human plasma ***LCAT*** with LDL , ***HDL2*** , HDL3 , and a reconstituted discoidal HDL ( rHDL ) were determined by the activity-inhibition method .	parallel	1
2859	10329423	3931;53369	LCAT;HDL3	In this study the equilibrium dissociation constants ( Kds ) for the ***interaction*** of pure human plasma ***LCAT*** with LDL , HDL2 , ***HDL3*** , and a reconstituted discoidal HDL ( rHDL ) were determined by the activity-inhibition method .	parallel	1
2860	10329425	1950;6772	EGF;Stat1	***EGF-induced*** ***activation*** of ***Stat1*** , Stat3 , and Stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes .	positive	1
2861	10329425	1950;6774	EGF;Stat3	***EGF-induced*** ***activation*** of Stat1 , ***Stat3*** , and Stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes .	positive	1
2862	10329425	1950;6777	EGF;Stat5b	***EGF-induced*** ***activation*** of Stat1 , Stat3 , and ***Stat5b*** is unrelated to the stimulation of DNA synthesis in cultured hepatocytes .	positive	1
2863	10329425	1950;6772	EGF;Stat1	In freshly isolated hepatocytes , ***EGF*** ***activated*** ***Stat1*** , Stat3 , and , particularly , Stat5b .	positive	1
2864	10329425	1950;6774	EGF;Stat3	In freshly isolated hepatocytes , ***EGF*** ***activated*** Stat1 , ***Stat3*** , and , particularly , Stat5b .	positive	1
2865	10329425	1950;5594	EGF;Erk1/2	In these cells ***EGF*** did not detectably activate Stat1 , Stat3 , or Stat5b but markedly ***stimulated*** MAP kinase ( ***Erk1/2*** ) .	positive	0
2866	10329429	6774;3569	STAT3;interleukin-6	Although a reason for the overexpression in myeloma cells is not understood , very interestingly , the promoter region of the HM1 .24 gene has a tandem repeat of three cis elements for a transcription factor , ***STAT3*** , which ***mediates*** ***interleukin-6*** ( IL-6 ) response gene expression .	target	0
2867	10329429	6774;684	STAT3;HM1.24 antigen	Since IL-6 is a differentiation factor for B cells , and known as a paracrine/autocrine growth factor for multiple myeloma cells , the expression of ***HM1.24 antigen*** may be ***regulated*** by the activation of ***STAT3*** .	target	1
2868	10329444	2321;7422	FLT-1;VEGF	We conclude that VEGF may inhibit contraction of hepatic stellate cells appearing during activation by culture , probably through attenuation of smooth muscle alpha-actin expression via upregulated ***VEGF*** ***receptor*** , ***FLT-1*** .	parallel	1
2869	10329457	596;2246	BCL-2;FGF1	These results suggest that there is a ***link*** between the endogenous ***FGF1*** signaling pathway and ***BCL-2*** in neuronal survival modulation .	parallel	0
2870	10329539	3700;7852	gp120;CXCR4	Identification of determinants of ***interaction*** between ***CXCR4*** and ***gp120*** of a dual-tropic HIV-1DH12 isolate .	parallel	1
2871	10329539	7852;3700	CXCR4;gp120	In this study , chimeric CXCR4-CXCR2 chemokine receptors were employed to identify the determinants involved in the ***interaction*** between ***CXCR4*** and the dual-tropic HIV-1DH12 ***gp120*** .	parallel	1
2872	10329539	3700;7852	gp120;CXCR4	Our results indicate that ( i ) HIV-1DH12 gp120 interacts primarily with the extracellular domains 1 ( E1 ) and 2 ( E2 ) of CXCR4 , ( ii ) the V1/V2 and the V3 regions interact with different domains of CXCR4 , and ( iii ) the V1/V2 region plays a more critical role in the ***interaction*** between ***CXCR4*** and HIV-1DH12 ***gp120*** .	parallel	1
2873	10329593	729230;6347	chemokine receptor 2;MCP-1	C-C ***chemokine receptor 2*** ( CCR2 ) is considered the major G-protein coupled ***receptor*** for ***MCP-1/JE*** .	parallel	1
2874	10329593	729230;3458	CCR2;IFNgamma	In granulomatous lungs , ***CCR2*** knockout increased mRNA for CCR2 agonists , MCP-1 , MCP-3 , and MCP-5 , but ***reduced*** IL-4 and ***IFNgamma*** mRNA .	positive	1
2875	10329593	729230;3565	CCR2;IL-4	In granulomatous lungs , ***CCR2*** knockout increased mRNA for CCR2 agonists , MCP-1 , MCP-3 , and MCP-5 , but ***reduced*** ***IL-4*** and IFNgamma mRNA .	positive	1
2876	10329623	7040;7039	TGF-beta;TGF-alpha	***TGF-beta*** ***cooperates*** with ***TGF-alpha*** to induce the self-renewal of normal erythrocytic progenitors : evidence for an autocrine mechanism .	parallel	0
2877	10329626	5966;182	c-Rel;Jagged1	Both ***c-Rel*** and RelA ***induced*** ***Jagged1*** gene expression , whereas a mutant defective for transactivation did not .	target	1
2878	10329626	5970;182	RelA;Jagged1	Both c-Rel and ***RelA*** ***induced*** ***Jagged1*** gene expression , whereas a mutant defective for transactivation did not .	target	1
2879	10329626	4792;4790	IkappaBalpha;NF-kappaB	Importantly , Jagged1 transcripts were also upregulated by endogenous NF-kappaB activation and this effect was inhibited by a dominant mutant of ***IkappaBalpha*** , a physiological ***inhibitor*** of ***NF-kappaB*** .	negative	1
2880	10329626	4790;182	NF-kappaB;Jagged1	Importantly , ***Jagged1*** transcripts were also ***upregulated*** by endogenous ***NF-kappaB*** activation and this effect was inhibited by a dominant mutant of IkappaBalpha , a physiological inhibitor of NF-kappaB .	positive	1
2881	10329627	23414;2623	FOG-2;GATA-1	Recently , two new members of the FOG family have been identified : a mammalian protein , ***FOG-2*** , that also ***associates*** with ***GATA-1*** and other mammalian GATA factors ; and U-shaped , a Drosophila protein that interacts with the Drosophila GATA protein Pannier .	parallel	0
2882	10329628	2932;1499	GSK-3beta;beta-catenin	Axin promotes the ***phosphorylation*** of ***beta-catenin*** by ***GSK-3beta*** , leading to beta-catenin degradation .	target	1
2883	10329646	10392;842	Nod1;caspase-9	***Nod1*** , an Apaf-1-like ***activator*** of ***caspase-9*** and nuclear factor-kappaB .	positive	1
2884	10329646	10392;4790	Nod1;NF-kappaB	Unlike Apaf-1 , ***Nod1*** ***induced*** activation of nuclear factor-kappa-B ( ***NF-kappaB*** ) and bound RICK , a CARD-containing kinase that also induces NF-kappaB activation .	target	1
2885	10329646	10392;8767	Nod1;RICK	Unlike Apaf-1 , ***Nod1*** induced activation of nuclear factor-kappa-B ( NF-kappaB ) and ***bound*** ***RICK*** , a CARD-containing kinase that also induces NF-kappaB activation .	parallel	1
2886	10329646	10392;4790	Nod1;NF-kappaB	***Nod1*** mutants ***inhibited*** ***NF-kappaB*** activity induced by RICK , but not that resulting from tumor necrosis factor-alpha stimulation .	positive	1
2887	10329658	387;2822	RhoA;PLD	Here we report that ***stimulation*** of ***PLD*** activity , measured in the presence of phosphatidylinositol 4,5-bisphosphate , by ***RhoA*** in membranes of HEK-293 cells expressing the m3 muscarinic acetylcholine receptor ( mAChR ) is phosphorylation-dependent .	positive	0
2888	10329658	387;2822	RhoA;PLD	Recombinant Rho-kinase-CAT mimicked the phosphorylation-dependent ***PLD*** ***stimulation*** by ***RhoA*** in HEK-293 cell membranes .	positive	0
2889	10329665	5617;5706	prolactin;p44	Short term incubation ( < 60 min ) of prolactin-responsive Nb2 lymphoma cells at high density selectively blocked ***prolactin*** ***stimulation*** of ***p42/p44*** mitogen-activated protein kinases and transcription factors Stat1 and Stat3 but not prolactin activation of Stat5 or the tyrosine kinase Jak2 .	positive	0
2890	10329666	6714;5894	Src;Raf-1	In baculovirus-infected Sf9 insect cells , Tvl-1 potentiates the ***activation*** of ***Raf-1*** by ***Src*** and Ras while in COS-1 cells it potentiates the activation of Raf-1 by EGF .	positive	1
2891	10329676	7124;6385	TNF-alpha;syndecan-4	In vitro studies demonstrated that ***TNF-alpha*** ***induced*** endothelial cell ***syndecan-4*** expression by both increasing syndecan-4 gene expression in an NF-kappaB-dependent manner and by prolonging syndecan-4 mRNA half-life .	target	1
2892	10329689	2185;6714	Pyk2;Src	***Pyk2-induced*** ***activation*** of ***Src*** is necessary for phosphorylation of Shc and p130Cas and their association with Grb2 and Crk , respectively , and for the activation of ERK and JNK cascades .	positive	1
2893	10329689	2885;5594	Grb2;ERK	***Grb2*** with a deleted carboxyl-terminal Src homology 3 domain partially ***blocked*** Pyk2-induced ***ERK*** and JNK pathways , whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk2 .	negative	0
2894	10329689	2885;5599	Grb2;JNK	***Grb2*** with a deleted carboxyl-terminal Src homology 3 domain partially ***blocked*** Pyk2-induced ERK and ***JNK*** pathways , whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk2 .	negative	0
2895	10329719	1435;5599	CSF-1;JNK-1	We were not able to show that ***CSF-1*** ***enhanced*** BMM ***JNK-1*** activity to a significant extent ; again , no role could be found for JNK-1 activity in the BMM apoptosis occurring after CSF-1 removal .	positive	0
2896	10329721	722;5627	c4bp;protein S	In conclusion , beta-chain SCR-2 contributes to the ***interaction*** of ***c4bp*** with ***protein S*** .	parallel	1
2897	10329721	722;5627	c4bp;protein S	***Interaction*** between ***protein S*** and complement C4b-binding protein ( ***c4bp*** ) .	parallel	1
2898	10329721	722;5627	c4bp;protein S	***c4bp*** can ***bind*** anticoagulant ***protein S*** , resulting in a decreased cofactor function of protein S for activated protein C .	parallel	1
2899	10329733	7157;596	p53;Bcl-2	***p53*** ***suppresses*** the activation of the ***Bcl-2*** promoter by the Brn-3a POU family transcription factor .	negative	1
2900	10329733	5457;596	Brn-3a;Bcl-2	p53 suppresses the ***activation*** of the ***Bcl-2*** promoter by the ***Brn-3a*** POU family transcription factor .	positive	1
2901	10329733	5457;596	Brn-3a;Bcl-2	This ***activation*** of the ***Bcl-2*** promoter by ***Brn-3a*** is strongly inhibited by the p53 anti-oncogene protein .	positive	1
2902	10329736	3643;3480	insulin receptor;insulin-like growth factor-1 receptor	***Interaction*** of ***insulin receptor*** substrate 3 with insulin receptor , insulin receptor-related receptor , ***insulin-like growth factor-1 receptor*** , and downstream signaling proteins .	parallel	1
2903	10329736	3643;3645	insulin receptor;insulin receptor-related receptor	***Interaction*** of ***insulin receptor*** substrate 3 with insulin receptor , ***insulin receptor-related receptor*** , insulin-like growth factor-1 receptor , and downstream signaling proteins .	parallel	1
2904	10329737	4193;7157	MDM2;p53	The cleaved ***MDM2*** loses the ability to promote p53 degradation and may potentially function in a dominant-negative fashion to ***stabilize*** ***p53*** .	positive	0
2905	10329743	348;5663	apolipoprotein E;presenilin-1	We found no evidence for a possible ***association*** between the ***presenilin-1*** polymorphism and the ***apolipoprotein E*** epsilon4 allele .	parallel	0
2906	10329795	3337;3308	Hsp40;Hsp70	***Hsp40*** , bound by unfolded polypeptide , can ***interact*** directly with ***Hsp70*** to stimulate the ATPase activity of Hsp70 .	parallel	1
2907	10329795	3337;3308	Hsp40;Hsp70	***Hsp40*** , bound by unfolded polypeptide , can interact directly with Hsp70 to ***stimulate*** the ATPase activity of ***Hsp70*** .	positive	0
2908	10329845	4790;3725	NF-kappaB;AP-1	***Binding*** of NF-AT , ***NF-kappaB*** , and ***AP-1*** was induced by T-cell receptor ( TcR ) stimulation , although there was no significant upregulation of binding by IL-2 stimulation .	parallel	1
2909	10329846	5970;4790	p65;p50	The binding activity of NF-kappaB ******p50/p65****** ***heterodimer*** and RBP-Jkappa was enhanced in these clones .	parallel	1
2910	10329978	7124;3667	TNF-alpha;IRS-1	In addition , ***TNF-alpha*** ***decreased*** insulin-stimulated ***IRS-1*** tyrosine phosphorylation by 40 % ( P < 0.05 ) .	negative	0
2911	10329978	7124;5706	TNF-alpha;p42	Furthermore , ***TNF-alpha*** ***repressed*** insulin-induced ***p42*** ( MAPK ) and p44 ( MAPK ) tyrosine phosphorylation by 81 % ( P < 0.01 ) .	negative	1
2912	10329981	3667;2885	IRS1;Grb2	Contraction also resulted in an apparent increase in the association of Raf-1 with p21Ras , although stimulation of MAP kinase signaling occurred independent of Shc , IRS1 , and IRS2 tyrosine phosphorylation or the formation of Shc/Grb2 or ******IRS1/Grb2****** ***complexes*** .	parallel	1
2913	10329981	6464;2885	Shc;Grb2	Contraction also resulted in an apparent increase in the association of Raf-1 with p21Ras , although stimulation of MAP kinase signaling occurred independent of Shc , IRS1 , and IRS2 tyrosine phosphorylation or the formation of ******Shc/Grb2****** or IRS1/Grb2 ***complexes*** .	parallel	1
2914	10330020	7082;100506658	ZO-1;occludin	Loss of ***ZO-1*** was ***associated*** with the altered localization of ZO-2 and ***occludin*** .	parallel	0
2915	10330020	7082;9414	ZO-1;ZO-2	Loss of ***ZO-1*** was ***associated*** with the altered localization of ***ZO-2*** and occludin .	parallel	0
2916	10330040	1991;4586	Neutrophil elastase;MUC5AC	***Neutrophil elastase*** ***increased*** ***MUC5AC*** mRNA levels by enhancing mRNA stability .	positive	0
2917	10330040	1991;4586	Neutrophil elastase;MUC5AC	***Neutrophil elastase*** ***increases*** ***MUC5AC*** mRNA and protein expression in respiratory epithelial cells .	positive	0
2918	10330040	1991;4586	Neutrophil elastase;MUC5AC	***Neutrophil elastase*** ***increased*** ***MUC5AC*** mRNA levels in a time-dependent manner in both cell culture systems .	positive	0
2919	10330040	1991;4586	Neutrophil elastase;MUC5AC	***Neutrophil elastase*** treatment also ***increased*** ***MUC5AC*** protein levels in A549 cells .	positive	0
2920	10330050	213;5579	albumin;PKC-beta	Glycated ***albumin*** ***stimulation*** of ***PKC-beta*** activity is linked to increased collagen IV in mesangial cells .	positive	0
2921	10330148	1436;1435	CSF-1R;CSF-1	The separation of multimeric complexes of the ***CSF-1*** ***receptor*** ( ***CSF-1R*** ) by anion-exchange chromatography enabled the enrichment of low-stoichiometry complexes .	parallel	1
2922	10330148	1436;867	CSF-1R;Cbl	A small pool of ***CSF-1R*** formed a multimeric ***complex*** with phosphatidylinositol-3 kinase ( PI-3 kinase ) , SHP-1 , Grb2 , Shc , c-Src , ***Cbl*** , and a significant number of tyrosine-phosphorylated proteins in CSF-1-stimulated cells .	parallel	1
2923	10330148	1436;6714	CSF-1R;c-Src	A small pool of ***CSF-1R*** formed a multimeric ***complex*** with phosphatidylinositol-3 kinase ( PI-3 kinase ) , SHP-1 , Grb2 , Shc , ***c-Src*** , Cbl , and a significant number of tyrosine-phosphorylated proteins in CSF-1-stimulated cells .	parallel	1
2924	10330148	1436;2885	CSF-1R;Grb2	A small pool of ***CSF-1R*** formed a multimeric ***complex*** with phosphatidylinositol-3 kinase ( PI-3 kinase ) , SHP-1 , ***Grb2*** , Shc , c-Src , Cbl , and a significant number of tyrosine-phosphorylated proteins in CSF-1-stimulated cells .	parallel	1
2925	10330148	1436;6464	CSF-1R;Shc	A small pool of ***CSF-1R*** formed a multimeric ***complex*** with phosphatidylinositol-3 kinase ( PI-3 kinase ) , SHP-1 , Grb2 , ***Shc*** , c-Src , Cbl , and a significant number of tyrosine-phosphorylated proteins in CSF-1-stimulated cells .	parallel	1
2926	10330157	115708;51605	GCD14p;Gcd10p	***GCD14p*** , a repressor of GCN4 translation , ***cooperates*** with ***Gcd10p*** and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae .	parallel	0
2927	10330157	51605;115708	Gcd10p;GCD14p	A mutation in gcd10 or deletion of LHP1 exacerbated the defects in cell growth and expression of mature tRNAiMet in gcd14 mutants , consistent with functional ***interactions*** between ***GCD14p*** , ***Gcd10p*** , and Lhp1p in vivo .	parallel	1
2928	10330159	7421;3725	VDR;AP-1	Transfected ***FLAG-VDR*** ***bound*** to the ***NFAT1-AP-1*** DNA binding element can be selectively precipitated from nuclear extracts that are made from cells treated with activating agents in the presence of 1,25 ( OH ) 2D3 .	parallel	1
2929	10330159	7421;4773	VDR;NFAT1	Transfected ***FLAG-VDR*** ***bound*** to the ***NFAT1-AP-1*** DNA binding element can be selectively precipitated from nuclear extracts that are made from cells treated with activating agents in the presence of 1,25 ( OH ) 2D3 .	parallel	1
2930	10330159	3725;4773	AP-1;NFAT1	These two events mediated by VDR effectively block the ******NFAT1-AP-1****** activation ***complex*** , resulting in an attenuation of activated GM-CSF transcription .	parallel	1
2931	10330159	7421;3725	vitamin D receptor;c-Jun	A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene : ***vitamin D receptor*** competes for DNA binding with NFAT1 and ***stabilizes*** ***c-Jun*** .	positive	0
2932	10330159	2353;3725	Fos;Jun	Secondly , VDR stabilizes the binding of a ******Jun-Fos****** ***heterodimer*** to the adjacent AP-1 portion of the element .	parallel	1
2933	10330159	2353;3725	Fos;AP-1	Secondly , VDR stabilizes the ***binding*** of a ***Jun-Fos*** heterodimer to the adjacent ***AP-1*** portion of the element .	parallel	1
2934	10330159	3725;7421	c-Jun;VDR	This appears to occur through a direct ***interaction*** between ***VDR*** and ***c-Jun*** , as demonstrated in vitro by direct glutathione S-transferase coprecipitation assays .	parallel	1
2935	10330164	2033;2959	p300;TFIIB	In this report , we analyze the specific domains of p300 required for the ***binding*** of ***p300*** to cyclin E-Cdk2 , ***TFIIB*** , and E1A and the ability of these proteins to interact with p300 , alone or in combination .	parallel	1
2936	10330164	2959;2033	TFIIB;p300	In contrast , 13S E1A , a pleiotropic transcriptional activator , does not inhibit ***TFIIB*** ***binding*** to ***p300*** , although it enhances the interaction of cyclin E-Cdk2 with p300 .	parallel	1
2937	10330167	11200;1111	Cds1;Chk1	These and other data indicate that ***Cds1*** ***prevents*** ***Chk1*** phosphorylation in HU-arrested cells , which suggests that Cds1 actively suppresses a repair process that leads to Chk1 phosphorylation .	negative	0
2938	10330169	2885;6464	Grb2;Shc	The concentrations of EGF for which PI 3-kinase inhibitors block Ras activation induce formation of ******Shc-Grb2****** ***complexes*** but not detectable EGF receptor phosphorylation and do not activate PI 3-kinase .	parallel	1
2939	10330170	4205;3725	MEF2;c-jun	Subsequently , however , we obtained evidence that GPCRs can potently ***stimulate*** the activity of the ***c-jun*** promoter through ***MEF2*** transcription factors , which do not act downstream from JNK .	positive	0
2940	10330172	7538;7124	TTP;TNF-alpha	We show here that ***TTP*** ***binding*** to the ***TNF-alpha*** ARE is dependent upon the integrity of both zinc fingers , since mutation of a single cysteine residue in either zinc finger to arginine severely attenuated the binding of TTP to the TNF-alpha ARE .	parallel	1
2941	10330176	2626;2627	GATA-4;GATA-6	Cooperative ***interaction*** between ***GATA-4*** and ***GATA-6*** regulates myocardial gene expression .	parallel	1
2942	10330177	10951;10155	M31;KAP-1	We observed colocalization of KAP-1 with M31 and M32 in interphase nuclei , lending support to the biochemical evidence that ***M31*** and M32 directly ***interact*** with ***KAP-1*** .	parallel	1
2943	10330177	10155;55888	KAP-1;ZFP	This work suggests a mechanism for the recruitment of HP1-like gene products by the ******KRAB-ZFP-KAP-1****** ***complex*** to specific loci within the genome through formation of heterochromatin-like complexes that silence gene activity .	parallel	1
2944	10330178	84962;2885	Ajuba;Grb2	***Ajuba*** specifically ***associated*** with ***Grb2*** in vitro and in vivo .	parallel	0
2945	10330181	1855;1499	Dvl-1;beta-catenin	***Dvl-1*** ***inhibited*** Axin-promoted glycogen synthase kinase 3beta-dependent phosphorylation of ***beta-catenin*** , and the DIX domain of Dvl-1 was required for this inhibitory activity .	negative	1
2946	10330181	1855;1499	Dvl-1;beta-catenin	Expression of ***Dvl-1*** in L cells ***induced*** the nuclear accumulation of ***beta-catenin*** , and deletion of the DIX domain abolished this activity .	target	1
2947	10330188	161882;2623	FOG;GATA-1	***FOG*** is coexpressed with GATA-1 in developing erythroid and megakaryocyte cell lineages and ***cooperates*** with ***GATA-1*** to control erythropoiesis .	parallel	0
2948	10330188	2626;23414	GATA-4;FOG-2	FOG-2 interacts with GATA factors , and ***interaction*** of ***GATA-4*** and ***FOG-2*** results in either synergistic activation or repression of GATA-dependent cardiac promoters , depending on the specific promoter and the cell type in which they are tested .	parallel	1
2949	10330189	1499;51176	beta-catenin;LEF-1	Excess beta-catenin can squelch reporter gene activation by ******LEF-1-beta-catenin****** ***complexes*** but not activation by the transcription factor VP16 .	parallel	1
2950	10330191	207;6198	PKB;S6K1	The results demonstrate that ***PKB*** ***mediates*** ***S6K1*** activation only as a function of constitutive membrane localization , whereas the activation of PKB appears both necessary and sufficient to induce 4E-BP1 phosphorylation independently of its intracellular location .	target	0
2951	10330191	2185;1978	Protein kinase B;eukaryotic translation initiation factor 4E-binding protein 1	***Protein kinase B*** localization and activation differentially ***affect*** S6 kinase 1 activity and ***eukaryotic translation initiation factor 4E-binding protein 1*** phosphorylation .	target	0
2952	10330191	207;2932	PKBalpha;GSK-3beta	The results demonstrate that two activated ***PKBalpha*** mutants , whose basal activity is equivalent to that of insulin-induced wild-type PKB , ***inhibit*** ***GSK-3beta*** to the same extent as a highly active , constitutively membrane-targeted wild-type PKB allele .	positive	1
2953	10330191	207;6198	PKB;S6K1	However , of these two mutants , only the constitutively membrane-targeted allele of ***PKB*** ***induces*** ***S6K1*** activation .	target	1
2954	10330191	207;2932	PKB;GSK-3beta	Furthermore , an interfering mutant of ***PKB*** , which ***blocks*** insulin-induced PKB activation and ***GSK-3beta*** inactivation , has no effect on S6K1 activation .	positive	0
2955	10330191	207;1978	PKB;4E-BP1	Surprisingly , all the activated PKB mutants , regardless of constitutive membrane localization , induce 4E-BP1 phosphorylation and the interfering ***PKB*** mutant ***blocks*** insulin-induced ***4E-BP1*** phosphorylation .	positive	0
2956	10330191	207;1978	PKB;4E-BP1	Surprisingly , all the activated ***PKB*** mutants , regardless of constitutive membrane localization , ***induce*** ***4E-BP1*** phosphorylation and the interfering PKB mutant blocks insulin-induced 4E-BP1 phosphorylation .	target	1
2957	10330192	6767;3312	Hop;Hsc70	Hip and ***Hop*** ***interact*** with ***Hsc70*** via a tetratricopeptide repeat domain .	parallel	1
2958	10330231	3552;3162	IL-1alpha;HO-1	These results demonstrate that TNF-alpha and ***IL-1alpha*** ***induction*** of ***HO-1*** requires PKC-mediated phosphorylation and PLA2 activation as well as oxidant generation .	target	1
2959	10330231	7124;3162	TNF-alpha;HO-1	These results demonstrate that ***TNF-alpha*** and IL-1alpha ***induction*** of ***HO-1*** requires PKC-mediated phosphorylation and PLA2 activation as well as oxidant generation .	target	1
2960	10330231	3552;8398	IL-1alpha;PLA2	These results demonstrate that TNF-alpha and ***IL-1alpha*** induction of HO-1 ***requires*** PKC-mediated phosphorylation and ***PLA2*** activation as well as oxidant generation .	target	0
2961	10330231	7124;8398	TNF-alpha;PLA2	These results demonstrate that ***TNF-alpha*** and IL-1alpha induction of HO-1 ***requires*** PKC-mediated phosphorylation and ***PLA2*** activation as well as oxidant generation .	target	0
2962	10330231	3552;3162	IL-1alpha;heme oxygenase-1	TNF-alpha and ***IL-1alpha*** ***induce*** ***heme oxygenase-1*** via protein kinase C , Ca2 + , and phospholipase A2 in endothelial cells .	target	1
2963	10330231	7124;3162	TNF-alpha;heme oxygenase-1	***TNF-alpha*** and IL-1alpha ***induce*** ***heme oxygenase-1*** via protein kinase C , Ca2 + , and phospholipase A2 in endothelial cells .	target	1
2964	10330231	3552;3162	IL-1alpha;HO-1	However , prolonged exposure , which downregulates most PKC isoforms , blocked ***induction*** of ***HO-1*** mRNA by ***IL-1alpha*** and TNF-alpha .	target	1
2965	10330231	7124;3162	TNF-alpha;HO-1	However , prolonged exposure , which downregulates most PKC isoforms , blocked ***induction*** of ***HO-1*** mRNA by IL-1alpha and ***TNF-alpha*** .	target	1
2966	10330276	961;3558	IAP;IL-2	Ligation of ***IAP*** acted in synergy with TCR to ***induce*** ***IL-2*** transcription and synthesis , but failed to synergize with the signal generated by CD16-7-zeta , while CD28 was a potent co-stimulator with both TCR and CD16-7-zeta .	target	1
2967	10330285	3586;3135	IL-10;HLA-G	***IL-10*** selectively ***induces*** ***HLA-G*** expression in human trophoblasts and monocytes .	target	1
2968	10330285	3586;3135	IL-10;HLA-G	Using Northern blot , RNase protection assay and RT-PCR analysis , we demonstrated that ***IL-10*** ***enhances*** steady-state levels of ***HLA-G*** transcription in cultured trophoblast cells .	positive	0
2969	10330285	3586;3135	IL-10;HLA-G	We further tested the effect of IL-10 on HLA-G gene transcription and protein expression in peripheral blood monocytes , showing that ***IL-10*** can ***up-regulate*** ***HLA-G*** cell surface expression in this cell type .	positive	1
2970	10330285	3586;3135	IL-10;HLA-G	***Induction*** of ***HLA-G*** expression by ***IL-10*** on monocytes may thus play a role in down-regulation of the immune response .	target	1
2971	10330372	28514;388585	Dll1;Hes5	The ***Dll1*** , Notch1 and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , Jagged1 , Mesp1 , Mesp2 and ***Hes5*** in the PSM .	negative	0
2972	10330372	28514;182	Dll1;Jagged1	The ***Dll1*** , Notch1 and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , ***Jagged1*** , Mesp1 , Mesp2 and Hes5 in the PSM .	negative	0
2973	10330372	28514;55897	Dll1;Mesp1	The ***Dll1*** , Notch1 and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , Jagged1 , ***Mesp1*** , Mesp2 and Hes5 in the PSM .	negative	0
2974	10330372	28514;145873	Dll1;Mesp2	The ***Dll1*** , Notch1 and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , Jagged1 , Mesp1 , ***Mesp2*** and Hes5 in the PSM .	negative	0
2975	10330372	4851;388585	Notch1;Hes5	The Dll1 , ***Notch1*** and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , Jagged1 , Mesp1 , Mesp2 and ***Hes5*** in the PSM .	negative	0
2976	10330372	4851;182	Notch1;Jagged1	The Dll1 , ***Notch1*** and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , ***Jagged1*** , Mesp1 , Mesp2 and Hes5 in the PSM .	negative	0
2977	10330372	4851;55897	Notch1;Mesp1	The Dll1 , ***Notch1*** and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , Jagged1 , ***Mesp1*** , Mesp2 and Hes5 in the PSM .	negative	0
2978	10330372	4851;145873	Notch1;Mesp2	The Dll1 , ***Notch1*** and RBPJkappa mutations ***disrupt*** the expression of Lunatic fringe ( L-fng ) , Jagged1 , Mesp1 , ***Mesp2*** and Hes5 in the PSM .	negative	0
2979	10330396	5902;7514	RanBP1;CRM1	***RanBP1*** as well as Ran-binding domains of the cytoplasmic nucleoporin RanBP2 ***promote*** the release of ***CRM1*** from the NPC .	positive	0
2980	10330396	5903;7514	RanBP2;CRM1	RanBP1 as well as Ran-binding domains of the cytoplasmic nucleoporin ***RanBP2*** ***promote*** the release of ***CRM1*** from the NPC .	positive	0
2981	10330402	2247;5594	bFGF;ERK	In contrast to the IGF-I-triggered pathway , PDGF-BB , ***bFGF*** , and EGF coordinately ***activated*** ***ERK*** and p38MAPK pathways .	positive	1
2982	10330402	1950;5594	EGF;ERK	In contrast to the IGF-I-triggered pathway , PDGF-BB , bFGF , and ***EGF*** coordinately ***activated*** ***ERK*** and p38MAPK pathways .	positive	1
2983	10330402	207;5594	PKB;ERK	When the ***ERK*** and p38MAPK pathways were simultaneously ***blocked*** by their specific inhibitors or an active form of either PI3-K or ***PKB*** ( Akt ) was transfected , PDGF-BB in turn initiated to maintain the differentiated SMC phenotype .	negative	0
2984	10330403	8215;1499	Dsh;beta-catenin	Coexpression of hemagglutinin-tagged Dishevelled ( Dsh ) revealed strong colocalization with Axin , suggesting that ***Dsh*** can ***interact*** with the Axin/APC/GSK3 / ***beta-catenin*** complex , and may thus modulate its activity .	parallel	1
2985	10330431	925;3932	CD8;Lck	In naive cytotoxic T cells , only a few ***CD8*** molecules are ***associated*** with ***Lck*** and the kinase is homogeneously distributed inside the cell .	parallel	0
2986	10330435	3596;3565	IL-13;IL-4	We conclude that ***IL-4*** and ***IL-13*** ***cooperate*** to initiate rapid Th2 cell-driven responses , and that although their functions overlap , they perform additive roles .	parallel	0
2987	10330437	6610;3558	neutral sphingomyelinase;IL-2	Moreover , specific inactivation of ***neutral sphingomyelinase*** by antisense RNA ***inhibited*** ***IL-2*** production and mitogen-activated protein kinase activation after TCR triggering .	positive	1
2988	10330485	1499;51176	beta-catenin;LEF-1	The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the ******LEF-1/beta-catenin****** ***complex*** in Xenopus laevis .	parallel	1
2989	10331406	3952;7351	leptin;UCP-2	In normal pancreatic islets , ***UCP-2*** is ***upregulated*** by ***leptin*** and is low in leptin-resistant islets of ZDF rats .	positive	1
2990	10331409	6750;2641	Somatostatin;Glucagon	***Somatostatin*** was infused ( 0.8 microg x kg ( -1 ) x min ( -1 ) ) to ***inhibit*** extrapancreatic ***Glucagon*** in dogs , and basal Glucagon was restored by intraportal infusion ( 0.65 ng x kg ( -1 ) x min ( -1 ) ) .	negative	1
2991	10331411	6517;3667	GLUT4;IRS-1	Overexpression of ***GLUT4*** in db / + TG6 mice markedly improved glucose-stimulated insulin secretion , by 250 % , and ***increased*** IRbeta , ***IRS-1*** , and p85alpha phosphorylation twofold , despite no change in concentration of these proteins .	positive	0
2992	10331411	6517;5295	GLUT4;p85alpha	Overexpression of ***GLUT4*** in db / + TG6 mice markedly improved glucose-stimulated insulin secretion , by 250 % , and ***increased*** IRbeta , IRS-1 , and ***p85alpha*** phosphorylation twofold , despite no change in concentration of these proteins .	positive	0
2993	10331420	7422;6347	Vascular endothelial growth factor;monocyte chemoattractant protein-1	***Vascular endothelial growth factor*** activates nuclear factor-kappaB and ***induces*** ***monocyte chemoattractant protein-1*** in bovine retinal endothelial cells .	target	1
2994	10331422	2247;3791	bFGF;KDR	These data suggest that ***bFGF*** ***stimulates*** ***KDR*** expression through a PKC and p44/p42 MAPK-dependent pathway not primarily involving the beta isoform of PKC , PKA , or PI-3 kinase .	positive	0
2995	10331422	2247;7422	bFGF;VEGF	Since ***bFGF*** ***induces*** ***VEGF*** expression and since increased KDR expression potentiates VEGF action , resulting in additional KDR expression and marked mitogenic activity , these data provide a novel mechanistic explanation for the angiogenic synergy between VEGF and bFGF .	target	1
2996	10331422	3791;7422	KDR;VEGF	Since bFGF induces VEGF expression and since increased ***KDR*** expression ***potentiates*** ***VEGF*** action , resulting in additional KDR expression and marked mitogenic activity , these data provide a novel mechanistic explanation for the angiogenic synergy between VEGF and bFGF .	positive	0
2997	10331424	3172;6927	HNF-4;HNF-1	On the other hand , in the presence of COUP TFII , the substitution impairs the enhancement of ***HNF-4-mediated*** ***activation*** of ***HNF-1*** promoter .	positive	1
2998	10331434	596;581	Bcl-2;Bax	Coimmunoprecipitation experiments showed that Bax-Bax interactions are greater in the mitochondrial-enriched membrane compartment of ALS motor cortex compared with controls , whereas ******Bax-Bcl-2****** ***interactions*** are lower in the membrane compartment of ALS motor cortex compared with controls .	parallel	1
2999	10331497	7124;6347	tumor necrosis factor alpha;MCP-1	Recombinant ***tumor necrosis factor alpha*** ( TNF-alpha ) ***induced*** a low level ***MCP-1*** mRNA accumulation in neutrophils , and addition of anti-TNF-alpha IgG blocked 30-70 % of MCP-1 mRNA expression induced with PHA-sup .	target	1
3000	10331507	356;355	Fas ligand;Fas	Fas , a member of the tumor necrosis receptor superfamily , is 36 kD surface protein containing a single transmembrane region and induces apoptosis by ******Fas-Fas ligand****** ***binding*** .	parallel	1
3001	10331605	2332;10146	FMRP;G3BP	Our results indicate that ***G3BP*** mRNA may be ***regulated*** by ***FMRP*** and supports the hypothesis that FMRP may modulate the transcription of specific transcripts .	target	1
3002	10331650	836;142	caspase-3;PARP	In intact human osteosarcoma cells undergoing spontaneous apoptosis , both PARP and PAR decreased after this early peak , concomitant with the ***inactivation*** and cleavage of ***PARP*** by ***caspase-3*** and the onset of substantial DNA and nuclear fragmentation .	negative	1
3003	10331651	142;5925	PARP;pRB	On the other hand , in a reconstituted reaction system , purified ***PARP*** from human placenta ***suppressed*** the ***pRB-phosphorylation*** activity in the presence of NAD and damaged DNA .	negative	1
3004	10331664	1382;5947	CRABP-II;CRABP-I	We examined the ligand protein ***interactions*** of two highly homologous cellular retinol binding proteins , CRBP and CRBP-II , and two highly homologous cellular retinoic acid binding proteins , ***CRABP-I*** and ***CRABP-II*** .	parallel	1
3005	10331664	1382;5948	CRABP-II;CRBP-II	We examined the ligand protein ***interactions*** of two highly homologous cellular retinol binding proteins , CRBP and ***CRBP-II*** , and two highly homologous cellular retinoic acid binding proteins , CRABP-I and ***CRABP-II*** .	parallel	1
3006	10331664	5947;5947	CRBP;CRABP-I	We examined the ligand protein ***interactions*** of two highly homologous cellular retinol binding proteins , ***CRBP*** and CRBP-II , and two highly homologous cellular retinoic acid binding proteins , ***CRABP-I*** and CRABP-II .	parallel	1
3007	10331664	5947;1382	CRBP;CRABP-II	We examined the ligand protein ***interactions*** of two highly homologous cellular retinol binding proteins , ***CRBP*** and CRBP-II , and two highly homologous cellular retinoic acid binding proteins , CRABP-I and ***CRABP-II*** .	parallel	1
3008	10331664	5947;5948	CRBP;CRBP-II	We examined the ligand protein ***interactions*** of two highly homologous cellular retinol binding proteins , ***CRBP*** and ***CRBP-II*** , and two highly homologous cellular retinoic acid binding proteins , CRABP-I and CRABP-II .	parallel	1
3009	10331664	5948;5947	CRBP-II;CRABP-I	We examined the ligand protein ***interactions*** of two highly homologous cellular retinol binding proteins , CRBP and ***CRBP-II*** , and two highly homologous cellular retinoic acid binding proteins , ***CRABP-I*** and CRABP-II .	parallel	1
3010	10331666	6278;2171	S100A7;E-FABP	Probable ***interaction*** between ***S100A7*** and ***E-FABP*** in the cytosol of human keratinocytes from psoriatic scales .	parallel	1
3011	10331666	6278;2171	S100A7;E-FABP	Finally , immunoprecipitations using antiserum against E-FABP revealed that ***S100A7*** ***co-immunoprecipitated*** with ***E-FABP*** from protein extracts of psoriatic scales .	parallel	1
3012	10331666	6278;2171	S100A7;E-FABP	These data indicate that ***E-FABP*** and ***S100A7*** might form a ***complex*** in the cytosol of human keratinocytes .	parallel	1
3013	10331987	650;3209	BMP-2;Hoxa-13	Administration of ***BMP-2*** at the anterior margin of the limb bud ***induced*** ectopic ***Hoxa-13*** expression in the anterior region of the muscle masses followed by ectopic muscle formation close to the source of exogenous BMP-2 .	target	1
3014	10332154	655;2247	OP-1;bFGF	This in vitro study showed that both bFGF and ***OP-1*** ***increased*** [ 3H ] thymidine incorporation , especially ***bFGF*** which stimulated it 3.5-fold at a dose of 30ng/ml .	positive	0
3015	10332738	30816;920	Env;CD4 molecule	The discovery that ***Env*** initially ***binds*** the ***CD4 molecule*** on the target cell surface and then makes subsequent interactions with one of several members of the chemokine receptor family has greatly enhanced the molecular understanding of HIV-1 entry .	parallel	1
3016	10332965	958;7124	CD40;tumor necrosis factor-alpha	Ligation of ***CD40*** ***induced*** ***tumor necrosis factor-alpha*** in rheumatoid arthritis : a novel mechanism of activation of synoviocytes .	target	1
3017	10332965	958;7124	CD40;TNF-alpha	Ligation of ***CD40*** on RA ST cells significantly ***increased*** the production of ***TNF-alpha*** in a dose dependent fashion .	positive	0
3018	10332965	3596;7124	IL-13;TNF-alpha	Interferon-gamma ( IFN-gamma ) , interleukin 4 ( IL-4 ) , or ***IL-13*** acted synergistically with CD40 ligation to ***enhance*** ***TNF-alpha*** production by ST cells .	positive	0
3019	10332965	3565;7124	IL-4;TNF-alpha	Interferon-gamma ( IFN-gamma ) , interleukin 4 ( ***IL-4*** ) , or IL-13 acted synergistically with CD40 ligation to ***enhance*** ***TNF-alpha*** production by ST cells .	positive	0
3020	10332965	3458;7124	Interferon-gamma;TNF-alpha	***Interferon-gamma*** ( IFN-gamma ) , interleukin 4 ( IL-4 ) , or IL-13 acted synergistically with CD40 ligation to ***enhance*** ***TNF-alpha*** production by ST cells .	positive	0
3021	10333295	590;7018	Butyrylcholinesterase;transferrin	***Butyrylcholinesterase*** is ***complexed*** with ***transferrin*** in chicken serum .	parallel	1
3022	10333295	7018;590	transferrin;BChE	The possible biomedical implications of a ***complex*** between ***transferrin*** and ***BChE*** which here has been shown to exist in chicken serum are briefly discussed .	parallel	1
3023	10333360	1435;1081	MCSF;HCG	***MCSF*** increased MMP-9 immunoreactivity ( P < 0.05 ) and moderately ***decreased*** ***HCG*** .	negative	0
3024	10333360	7040;1081	TGFbeta;HCG	***TGFbeta*** ***decreased*** ***HCG*** ( P < 0.041 ) and increased fFN ( P < 0.042 ) .	negative	0
3025	10333497	6927;2305	HNF-1;HNF-3	Sequences were inserted at position -21 , separating both HNF-3 binding sites from the HNF-1-HNF-6 binding site , and position -5 , separating the ******HNF-3-HNF-1-HNF-6****** ***complex*** from the transcription start site .	parallel	1
3026	10333497	6927;3175	HNF-1;HNF-6	Sequences were inserted at position -21 , separating both HNF-3 binding sites from the HNF-1-HNF-6 binding site , and position -5 , separating the ******HNF-3-HNF-1-HNF-6****** ***complex*** from the transcription start site .	parallel	1
3027	10333497	3175;2305	HNF-6;HNF-3	Sequences were inserted at position -21 , separating both HNF-3 binding sites from the HNF-1-HNF-6 binding site , and position -5 , separating the ******HNF-3-HNF-1-HNF-6****** ***complex*** from the transcription start site .	parallel	1
3028	10333542	5617;4313	prolactin;matrix metalloproteinase (MMP)-2	We previously reported that ***prolactin*** ( PRL ) ***stimulated*** ***matrix metalloproteinase (MMP)-2*** activity to degrade collagen type IV as a mechanism of structural luteolysis .	positive	0
3029	10333542	4323;4313	MT-MMP;MMP-2	***Activation*** of ***pro-MMP-2*** by membrane type-MMP ( ***MT-MMP*** ) is reported to be a rate-limiting step for catalytic function .	positive	1
3030	10334300	3952;5443	leptin;alpha-MSH	This ***alpha-MSH/MC4-R*** system may be ***inhibited*** by ***leptin*** and/or insulin .	negative	1
3031	10334300	3952;4160	leptin;MC4-R	This ***alpha-MSH/MC4-R*** system may be ***inhibited*** by ***leptin*** and/or insulin .	negative	1
3032	10334302	3953;3952	leptin receptor;leptin	Thus , the two ***leptin receptor*** isoforms , ObRa and ObRb , ***mediate*** ***leptin*** internalization by a coated pit-dependent mechanism , leptin degradation by a lysosomal pathway , and ligand-induced receptor downregulation .	target	0
3033	10334384	3439;3569	IFN-alpha;IL-6	In fact , ***IFN-alpha*** significantly ***stimulated*** the secretion of ***IL-6*** and TNF-alpha in CD40-activated B-CLL cells ( p < 0.01 ) .	positive	0
3034	10334384	3439;7124	IFN-alpha;TNF-alpha	In fact , ***IFN-alpha*** significantly ***stimulated*** the secretion of IL-6 and ***TNF-alpha*** in CD40-activated B-CLL cells ( p < 0.01 ) .	positive	0
3035	10334387	1508;3553	cathepsin B;IL-1beta	The present results suggest that ***cathepsin B*** , cathepsin L , and cathepsin D in kidney lysosomes are involved in the metabolic ***degradation*** of human ***IL-1beta*** .	negative	1
3036	10334387	1509;3553	cathepsin D;IL-1beta	The present results suggest that cathepsin B , cathepsin L , and ***cathepsin D*** in kidney lysosomes are involved in the metabolic ***degradation*** of human ***IL-1beta*** .	negative	1
3037	10334387	1514;3553	cathepsin L;IL-1beta	The present results suggest that cathepsin B , ***cathepsin L*** , and cathepsin D in kidney lysosomes are involved in the metabolic ***degradation*** of human ***IL-1beta*** .	negative	1
3038	10334392	3558;3458	IL-2;IFN-gamma	***IL-2*** or retinoids alone could ***induce*** low but significant levels of ***IFN-gamma*** .	target	1
3039	10334393	1436;1435	CSF-1R;CSF-1	In addition , ***CSF-1*** ***receptor*** ( ***CSF-1R*** ) blocking experiments indicated that a proportion of the GM-CSF-induced DNA synthesis is due to endogenous levels of CSF-1 .	parallel	1
3040	10334872	4353;23430	myeloperoxidase;mast cell tryptase	Neutrophil ***myeloperoxidase*** is a potent and selective ***inhibitor*** of ***mast cell tryptase*** .	negative	1
3041	10334872	4353;23430	MPO;mast cell tryptase	***MPO*** ***inhibits*** human ***mast cell tryptase*** in a time-dependent manner with an IC50 of 16 nM at 1 h.	negative	1
3042	10334922	650;5743	BMP-2;COX-2	Since ***BMP-2*** alone ***induced*** the expression of ***COX-2*** and ODF genes in osteoblast-like cells , it appears to be one of the regulating factors of osteoclastogenesis .	target	1
3043	10334922	650;8600	BMP-2;ODF	Since ***BMP-2*** alone ***induced*** the expression of COX-2 and ***ODF*** genes in osteoblast-like cells , it appears to be one of the regulating factors of osteoclastogenesis .	target	1
3044	10334922	650;5743	BMP-2;cyclooxygenase-2	Western blot analysis showed that a simultaneous addition of ***BMP-2*** and IL-1alpha synergistically ***enhanced*** ***cyclooxygenase-2*** ( COX-2 ) expression in osteoblast-like cells .	positive	0
3045	10334922	3552;5743	IL-1alpha;cyclooxygenase-2	Western blot analysis showed that a simultaneous addition of BMP-2 and ***IL-1alpha*** synergistically ***enhanced*** ***cyclooxygenase-2*** ( COX-2 ) expression in osteoblast-like cells .	positive	0
3046	10334923	4301;7082	AF-6;ZO-1	In vivo ***interaction*** of ***AF-6*** with activated Ras and ***ZO-1*** .	parallel	1
3047	10334923	4301;7082	AF-6;ZO-1	We previously showed that an ***AF-6*** fragment containing the amino-terminal ( N-terminal ) RA domain directly ***binds*** to activated Ras and ***ZO-1*** in vitro .	parallel	1
3048	10334923	4301;7082	AF-6;ZO-1	Moreover , we showed that ***AF-6*** was ***coimmunoprecipitated*** with ***ZO-1*** from Rat1 cells .	parallel	1
3049	10334923	4301;7082	AF-6;ZO-1	Taken together , these results indicate that the Ras-interacting region on AF-6 is structurally similar to that on Raf-1 and on RalGDS and that ***AF-6*** ***interacts*** with activated Ras and ***ZO-1*** in vivo .	parallel	1
3050	10335401	3700;920	gp120;CD4	Furthermore , RD6-Y664 did not show any inhibition of ******gp120-CD4****** ***interaction*** , or binding of anti-CXCR4 antibody to CXCR4 .	parallel	1
3051	10335944	596;581	Bcl-2;Bax	The ***interaction*** of ***Bcl-2*** and ***Bax*** regulates apoptosis in biliary epithelial cells of rats with obstructive jaundice .	parallel	1
3052	10335944	596;581	Bcl-2;Bax	The ***interaction*** between ***Bcl-2*** and ***Bax*** triggers apoptosis in BEC and acts as a cell rheostat in BEC hyperplasia and its involution after biliary decompression .	parallel	1
3053	10336054	3265;351	p21ras;Abeta	We previously reported on the elevated expression of ***p21ras*** ***associated*** with paired helical filament formation and ***Abeta-deposits*** .	parallel	0
3054	10336116	627;2890	Brain-derived neurotrophic factor;GluR1	***Brain-derived neurotrophic factor*** treatment specifically ***increased*** the protein levels of ***GluR1*** ( 193 + / -22 % ) and GluR2/3 ( 182 + / -11 % ) in cultured rat neocortical neurons .	positive	0
3055	10336116	627;2892	Brain-derived neurotrophic factor;GluR2/3	***Brain-derived neurotrophic factor*** treatment specifically ***increased*** the protein levels of GluR1 ( 193 + / -22 % ) and ***GluR2/3*** ( 182 + / -11 % ) in cultured rat neocortical neurons .	positive	0
3056	10336162	3952;4852	leptin;neuropeptide Y	***leptin*** is secreted by adipocytes in proportion to fat content , exhibits a daily rhythm in plasma that is synchronized to feeding time , and ***inhibits*** activity of arcuate ***neuropeptide Y*** neurons that stimulate feeding behavior and regulate metabolism .	negative	1
3057	10336162	3952;4852	leptin;neuropeptide Y	If the effects of obesity on food-entrained rhythms are mediated by ***leptin*** ***inhibition*** of ***neuropeptide Y*** neurons , then these rhythms may be enhanced in leptin-insensitive Zucker obese rats .	negative	1
3058	10336187	51052;5617	PrRP;prolactin	prolactin-releasing peptide ( ***PrRP*** ) , a novel peptide identified as the endogenous ligand for an orphan receptor isolated from the pituitary , is a potent ***stimulator*** of ***prolactin*** release .	positive	0
3059	10336256	348;4137	apolipoprotein E;tau	***Regulation*** of ***tau*** phosphorylation in microtubule fractions by ***apolipoprotein E*** .	target	1
3060	10336256	348;4137	apoE;tau	We found that ***apoE*** ***attenuates*** ***tau*** hyperphosphorylation in the fractions , but the pattern was indistinguishable for the different isoforms .	negative	0
3061	10336413	4792;4790	IkappaBalpha;NF-kappaB	The Tax oncoprotein of human T cell leukemia virus type 1 constitutively activates transcription factor NF-kappaB by a mechanism involving Tax-induced phosphorylation of ***IkappaBalpha*** , a labile cytoplasmic ***inhibitor*** of ***NF-kappaB*** .	negative	1
3062	10336416	2280;6261	FKBP12;RyR1	FK506-binding protein ( ***FKBP12*** ) has been found to be ***associated*** with the skeletal muscle ryanodine receptor ( ***RyR1*** ) ( calcium release channel ) , whereas FKBP12.6 , a novel isoform of FKBP , is selectively associated with the cardiac ryanodine receptor ( RyR2 ) .	parallel	0
3063	10336416	2281;6262	FKBP12.6;RyR2	FK506-binding protein ( FKBP12 ) has been found to be associated with the skeletal muscle ryanodine receptor ( RyR1 ) ( calcium release channel ) , whereas ***FKBP12.6*** , a novel isoform of FKBP , is selectively ***associated*** with the cardiac ryanodine receptor ( ***RyR2*** ) .	parallel	0
3064	10336416	2281;6262	FKBP12.6;RyR2	Although FKBP12.6 differs from FKBP12 by only 18 of 108 amino acids , ***FKBP12.6*** selectively ***binds*** to ***RyR2*** and exchanges with bound FKBP12.6 of RyR2 , whereas both FKBP isoforms bind to RyR1 and exchange with bound FKBP12 of RyR1 .	parallel	1
3065	10336432	8575;5610	PACT;PKR	RAX has a high sequence homology to human ***PACT*** , which ***activates*** ***PKR*** in the absence of dsRNA .	positive	1
3066	10336432	8575;5610	RAX;PKR	Although ***RAX*** also can directly ***activate*** ***PKR*** in vitro , overexpression of RAX does not induce PKR activation or inhibit growth of interleukin-3 ( IL-3 ) - dependent cells in the presence of IL-3 .	positive	1
3067	10336432	8575;5610	RAX;PKR	However , IL-3 deprivation as well as diverse cell stress treatments including arsenite , thapsigargin , and H2O2 , which are known to inhibit protein synthesis , induce the rapid phosphorylation of RAX followed by ******RAX-PKR****** ***association*** and activation of PKR .	parallel	0
3068	10336432	8575;5610	RAX;PKR	Therefore , cellular ***RAX*** may be a stress-activated , physiologic ***activator*** of ***PKR*** that couples transmembrane stress signals and protein synthesis .	positive	1
3069	10336433	5111;466	PCNA;ATF-1	Inducibility of the human PCNA promoter by E1A 243R is conferred by the cis-acting ***PCNA*** E1A-responsive element ( PERE ) , which ***associates*** with the ***ATF-1*** , cAMP response element-binding protein ( CREB ) , and RFX1 transcription factors and is modulated by cellular proteins such as the coactivator CREB-binding protein ( CBP ) and tumor suppressor p107 ( Labrie , C. , Lee , B.	parallel	0
3070	10336433	5111;1385	PCNA;CREB	Inducibility of the human PCNA promoter by E1A 243R is conferred by the cis-acting ***PCNA*** E1A-responsive element ( PERE ) , which ***associates*** with the ATF-1 , cAMP response element-binding protein ( ***CREB*** ) , and RFX1 transcription factors and is modulated by cellular proteins such as the coactivator CREB-binding protein ( CBP ) and tumor suppressor p107 ( Labrie , C. , Lee , B.	parallel	0
3071	10336433	5111;5989	PCNA;RFX1	Inducibility of the human PCNA promoter by E1A 243R is conferred by the cis-acting ***PCNA*** E1A-responsive element ( PERE ) , which ***associates*** with the ATF-1 , cAMP response element-binding protein ( CREB ) , and ***RFX1*** transcription factors and is modulated by cellular proteins such as the coactivator CREB-binding protein ( CBP ) and tumor suppressor p107 ( Labrie , C. , Lee , B.	parallel	0
3072	10336449	6285;3000	S100b;retGC-1	In addition to recombinant bovine GCAPs , constitutively active mutants of GCAPs that activate retGC-1 in a [ Ca2 + ] - independent manner and bovine brain ***S100b*** that ***activates*** ***retGC-1*** in the presence of approximately 10 microM [ Ca2 + ] were used to investigate whether these activations take place through a similar mechanism , and whether [ Ca2 + ] is directly involved in the dimerization .	positive	1
3073	10336453	1437;6774	CSF;STAT3	Notably , in the presence of GM-CSF , ***G-CSF*** induced the tyrosine phosphorylation of STAT3 but failed to ***induce*** the nuclear translocation of tyrosine-phosphorylated ***STAT3*** .	target	1
3074	10336453	1437;6774	CSF;STAT3	Notably , in the presence of GM-CSF , ***G-CSF*** ***induced*** the tyrosine phosphorylation of ***STAT3*** but failed to induce the nuclear translocation of tyrosine-phosphorylated STAT3 .	target	1
3075	10336453	1437;84959	GM-CSF;p70	***GM-CSF*** ***induced*** activation of not only ***p70*** S6 kinase , but also of MAP kinase .	target	1
3076	10336453	1437;6774	CSF;STAT3	PD98059 , an MEK1 inhibitor , inhibited the ***G-CSF-dependent*** serine727 ***phosphorylation*** of ***STAT3*** and blocked the inhibitory effect of GM-CSF on G-CSF-dependent nuclear translocation of STAT3 .	target	1
3077	10336453	1437;6774	CSF;STAT3	From the analysis of confocal laser scanning fluorescence microscopy and differential centrifugation , it was clearly demonstrated that ***G-CSF*** ***induced*** nuclear translocation of tyrosine-phosphorylated ***STAT3*** .	target	1
3078	10336463	7124;5970	TNF-alpha;p65	RAI protein appeared to be located in the nucleus and colocalized with NF-kappaB ***p65*** that was ***activated*** by ***TNF-alpha*** .	positive	1
3079	10336466	6722;6749	SRF;SSRP1	Using a modified yeast one-hybrid screen to identify potential SRF cofactors , we found that ***SRF*** ***interacts*** with the high mobility group factor ***SSRP1*** ( structure-specific recognition protein ) .	parallel	1
3080	10336466	6749;6722	SSRP1;SRF	SSRP1 does not bind the CArG box , but ***interaction*** of ***SSRP1*** with ***SRF*** dramatically increases the DNA binding activity of SRF , resulting in synergistic transcriptional activation of native and artificial SRF-dependent promoters .	parallel	1
3081	10336473	7422;285	vascular endothelial growth factor;angiopoietin-2	Hypoxia and ***vascular endothelial growth factor*** selectively ***up-regulate*** ***angiopoietin-2*** in bovine microvascular endothelial cells .	positive	1
3082	10336478	4486;4485	RON;MSP	The ***RON*** receptor-type tyrosine kinase , a member of the hepatocyte growth factor receptor family , is a ***receptor*** for macrophage-stimulating protein ( ***MSP*** ) .	parallel	1
3083	10336480	857;7422	caveolin-1;VEGF	Furthermore , we show that ***caveolin-1*** can function as a negative ***regulator*** of ***VEGF-R*** ( KDR ) signal transduction in vivo .	negative	1
3084	10336480	7422;857	VEGF;caveolin-1	***VEGF-induced*** ***down-regulation*** of ***caveolin-1*** expression also resulted in the morphological loss of cell surface caveolae organelles as seen by transmission electron microscopy .	negative	1
3085	10336480	7422;857	VEGF;caveolin-1	A variety of well characterized angiogenesis inhibitors ( including angiostatin , fumagillin , 2-methoxy estradiol , transforming growth factor-beta , and thalidomide ) effectively blocked ***VEGF-induced*** ***down-regulation*** of ***caveolin-1*** as seen by immunoblotting and immunofluorescence microscopy .	negative	1
3086	10336480	7422;857	VEGF;caveolin-1	PD98059 , a specific inhibitor of mitogen-activated protein kinase and a known angiogenesis inhibitor , also blocked the observed ***VEGF-induced*** ***down-regulation*** of ***caveolin-1*** .	negative	1
3087	10336493	1869;1719	E2F1;dihydrofolate reductase	***Activation*** of the murine ***dihydrofolate reductase*** promoter by ***E2F1*** .	positive	1
3088	10336495	5465;2033	PPARalpha;p300	In contrast to the ***interaction*** of ***PPARalpha*** with the coactivator protein , ***p300*** , association of the receptor with NCoR did not require any part of the PPARalpha ligand binding domain .	parallel	1
3089	10336516	4803;4804	NGF;p75	We have identified a novel nonpeptidic molecule , ALE-0540 , that inhibits the ***binding*** of ***NGF*** to tyrosine kinase ( Trk ) A or both ***p75*** and TrkA ( IC50 5.88 + / - 1 .	parallel	1
3090	10336516	4803;4914	NGF;Trk	We have identified a novel nonpeptidic molecule , ALE-0540 , that inhibits the ***binding*** of ***NGF*** to tyrosine kinase ( ***Trk*** ) A or both p75 and TrkA ( IC50 5.88 + / - 1 .	parallel	1
3091	10336668	321;351	Mint2;APP	In Mint2/APP-cotransfected cells , ***Mint2*** reorganizes the subcellular distribution of APP and also ***increases*** the steady-state levels of ***APP*** .	positive	0
3092	10336676	2912;5594	mGluR2;ERK2	In particular , mGluR1a and ***mGluR2*** preferentially ***mediated*** phosphorylation and activation of ***ERK2*** in a pertussis toxin ( PTX ) - sensitive and concentration-dependent manner .	target	0
3093	10336677	7025;2516	COUP-TFI;SF-1	Electrophoretic mobility shift assays confirmed specific ***binding*** of Sp1 , ***SF-1*** and ***COUP-TFI*** .	parallel	1
3094	10336726	7200;4842	TRH;NOS	The findings suggest that mobilization of intracellular Ca2 + by ***TRH*** stimulation ***activates*** Ca2 + - dependent ***NOS*** in GH3 cells .	positive	1
3095	10336827	3479;2690	IGF-I;GHR	The similar action of pGH and ***IGF-I*** on preadipocyte proliferation and differentiation , ***associated*** with the similar expression of ***GHR*** and IGF-IR mRNA in LW and MS pigs , suggests that the GH/IGF-I axis is not impaired in MS pigs .	parallel	0
3096	10336864	348;3949	apoE;LDLr	We are using this system to express a panel of 2E8 variant Fabs that will be used as probes to establish the structural features responsible for the ***binding*** of ***apoE*** to the ***LDLr*** .	parallel	1
3097	10337591	1019;1029	Cdk4;p16	The p16 level was found to be almost the same in both normal and transformed cells , a loss of ******p16-Cdk4****** ***interaction*** was observed in two of the three melanoma cell lines .	parallel	1
3098	10337864	949;4018	CD36 and LIMPII analogous-1;lipoprotein	***CD36 and LIMPII analogous-1*** ( CLA-1 ) , a human homolog of the rodent scavenger receptor B1 ( SR-B1 ) , ***binds*** high-density ***lipoprotein*** ( HDL ) and mediates the selective uptake of HDL cholesterol ester ( CE ) by cultured transfected cells .	parallel	1
3099	10337866	155;7350	beta3AR;UCP1	Our results suggest that the ***beta3AR*** mutation is ***associated*** with hypertriglyceridemia and the ***UCP1*** polymorphism may be a weak contributing factor to obesity in Japanese men .	parallel	0
3100	10337915	116;3458	PACAP;IFNgamma	***VIP/PACAP*** ***inhibit*** the production of IL-12 , IL-6 , tumor necrosis factor alpha ( TNFalpha ) , and interferon gamma ( ***IFNgamma*** ) in vivo in endotoxemic mice .	negative	1
3101	10337915	116;3569	PACAP;IL-6	***VIP/PACAP*** ***inhibit*** the production of IL-12 , ***IL-6*** , tumor necrosis factor alpha ( TNFalpha ) , and interferon gamma ( IFNgamma ) in vivo in endotoxemic mice .	negative	1
3102	10337915	116;7124	PACAP;tumor necrosis factor alpha	***VIP/PACAP*** ***inhibit*** the production of IL-12 , IL-6 , ***tumor necrosis factor alpha*** ( TNFalpha ) , and interferon gamma ( IFNgamma ) in vivo in endotoxemic mice .	negative	1
3103	10338	1442;5617	placental lactogen;prolactin	***Inhibition*** of pituitary ***prolactin*** secretion by human ***placental lactogen*** in rats .	negative	1
3104	10338369	1437;7040	GM-CSF;TGF-beta1	However , ***GM-CSF*** ( 1 ng / ml ) up-regulates its own protein expression , but does not effect TGF-beta1 mRNA protein expression in epithelial and stromal cells , and actually ***inhibits*** the cell-associated ***TGF-beta1*** protein in stromal cells ( P < 0.05 ) .	negative	1
3105	10338476	3553;1673	IL-1beta;HBD-2	Human beta-defensins are expressed in oral tissues , and the proteins are secreted in saliva ; HBD-1 expression was constitutive , while ***HBD-2*** expression was ***induced*** by ***IL-1beta*** and LPS .	target	1
3106	10339431	1677;1676	CAD;ICAD	***CAD*** is ***complexed*** with its inhibitor , ***ICAD*** , in growing , non-apoptotic cells [ 2 ] [ 7 ] .	parallel	1
3107	10339432	5883;11200	Rad9;Rad53	Rad9 hyperphosphorylation , which occurs after DNA damage [ 4 ] [ 5 ] [ 6 ] , was absent in the BRCT mutants , as was ***Rad9-dependent*** ***phosphorylation*** of the ***Rad53*** protein .	target	1
3108	10339433	8737;8772	RIP;FADD	The tumor necrosis factor receptor 1 ( TNFR1 ) and the Fas receptor recruit complexes formed by the ***interactions*** between ***RIP*** kinase , TRADD , ***FADD*** and RAIDD - adaptor proteins that contain death domains - which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] .	parallel	1
3109	10339433	8737;8717	RIP;TRADD	The tumor necrosis factor receptor 1 ( TNFR1 ) and the Fas receptor recruit complexes formed by the ***interactions*** between ***RIP*** kinase , ***TRADD*** , FADD and RAIDD - adaptor proteins that contain death domains - which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] .	parallel	1
3110	10339433	8717;8772	TRADD;FADD	The tumor necrosis factor receptor 1 ( TNFR1 ) and the Fas receptor recruit complexes formed by the ***interactions*** between RIP kinase , ***TRADD*** , ***FADD*** and RAIDD - adaptor proteins that contain death domains - which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] .	parallel	1
3111	10339475	4792;7124	IkappaB-alpha;TNF-alpha	We found that overexpression of ***IkappaB-alpha*** in endothelial cells using a recombinant adenovirus ***prevented*** tumor necrosis factor-alpha ( ***TNF-alpha*** ) - induced degradation of IkappaB-alpha and suppressed the upregulation of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth-related activity-alpha ( GRO-alpha ) by TNF-alpha .	negative	0
3112	10339475	4792;3383	IkappaB-alpha;intercellular adhesion molecule-1	We found that overexpression of ***IkappaB-alpha*** in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha ( TNF-alpha ) - induced degradation of IkappaB-alpha and ***suppressed*** the upregulation of vascular cell adhesion molecule-1 ( VCAM-1 ) , ***intercellular adhesion molecule-1*** ( ICAM-1 ) , and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth-related activity-alpha ( GRO-alpha ) by TNF-alpha .	negative	1
3113	10339475	4792;7412	IkappaB-alpha;vascular cell adhesion molecule-1	We found that overexpression of ***IkappaB-alpha*** in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha ( TNF-alpha ) - induced degradation of IkappaB-alpha and ***suppressed*** the upregulation of ***vascular cell adhesion molecule-1*** ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth-related activity-alpha ( GRO-alpha ) by TNF-alpha .	negative	1
3114	10339478	2889;1399	C3G;CrkL	Taken together , these results indicate that the ******CrkL-C3G****** ***complex*** activates VLA-4 and VLA-5 in hematopoietic cells , possibly by activating the small GTP binding proteins , including R-Ras , through the guanine nucleotide exchange activity of C3G .	parallel	1
3115	10339478	2889;3678	C3G;VLA-5	Taken together , these results indicate that the ***CrkL-C3G*** complex ***activates*** VLA-4 and ***VLA-5*** in hematopoietic cells , possibly by activating the small GTP binding proteins , including R-Ras , through the guanine nucleotide exchange activity of C3G .	positive	1
3116	10339478	1399;3678	CrkL;VLA-5	Taken together , these results indicate that the ***CrkL-C3G*** complex ***activates*** VLA-4 and ***VLA-5*** in hematopoietic cells , possibly by activating the small GTP binding proteins , including R-Ras , through the guanine nucleotide exchange activity of C3G .	positive	1
3117	10339482	2056;2185	erythropoietin;Protein kinase B	***Protein kinase B*** ( c-Akt ) , phosphatidylinositol 3-kinase , and STAT5 are ***activated*** by ***erythropoietin*** ( EPO ) in HCD57 erythroid cells but are constitutively active in an EPO-independent , apoptosis-resistant subclone ( HCD57-SREI cells ) .	positive	1
3118	10339482	2056;6776	erythropoietin;STAT5	Protein kinase B ( c-Akt ) , phosphatidylinositol 3-kinase , and ***STAT5*** are ***activated*** by ***erythropoietin*** ( EPO ) in HCD57 erythroid cells but are constitutively active in an EPO-independent , apoptosis-resistant subclone ( HCD57-SREI cells ) .	positive	1
3119	10339482	2056;2185	erythropoietin;Protein kinase B	We found that ***erythropoietin*** ( EPO ) and stem cell factor ( SCF ) ***activated*** ***Protein kinase B*** ( PKB/Akt ) in EPO-dependent HCD57 erythroid cells .	positive	1
3120	10339482	4254;2185	SCF;Protein kinase B	We found that erythropoietin ( EPO ) and stem cell factor ( ***SCF*** ) ***activated*** ***Protein kinase B*** ( PKB/Akt ) in EPO-dependent HCD57 erythroid cells .	positive	1
3121	10339488	1958;2152	EGR-1;tissue factor	Vascular endothelial cell growth factor-induced ***tissue factor*** expression in endothelial cells is ***mediated*** by ***EGR-1*** .	target	0
3122	10339499	3458;4084	IFN-gamma;Mad1	In contrast , TPA + ***IFN-gamma*** costimulation neither ***increased*** the expression of ***Mad1*** or other Mad/mnt family genes nor altered heterodimerization or DNA-binding activity of Mad1 .	positive	0
3123	10339547	983;9013	cdc2;TAFI110	We have shown that transcription initiation factor ( TIF ) - IB/SL1 is inactivated during mitosis by ***cdc2/cyclin*** B-directed ***phosphorylation*** of ***TAFI110*** .	target	1
3124	10339564	990;1017	HsCdc6;Cdk2	***HsCdc6*** is an excellent ***substrate*** for ***Cdk2*** in vitro and is phosphorylated in vivo at three sites ( Ser-54 , Ser-74 , and Ser-106 ) that are phosphorylated by Cdk2 in vitro , strongly suggesting that HsCdc6 is an in vivo Cdk substrate .	parallel	1
3125	10339565	207;5728	Akt;PTEN	***Akt*** activation increased Bad phosphorylation and ***promoted*** ***PTEN*** - / - cell survival .	positive	0
3126	10339565	5728;207	PTEN;Akt	Our studies suggest that ***PTEN*** ***regulates*** the phosphatidylinositol 3,4 , 5,-trisphosphate and ***Akt*** signaling pathway and consequently modulates two critical cellular processes : cell cycle progression and cell survival .	target	1
3127	10339577	8945;1499	beta-Trcp;beta-catenin	Here we show that phosphorylated ***beta-catenin*** is specifically ***recognized*** by ***beta-Trcp*** , an F-box/WD40-repeat protein that also associates with Skp1 , an essential component of the ubiquitination apparatus .	target	1
3128	10339589	9467;695	Sab;Bruton's tyrosine kinase	***Bruton's tyrosine kinase*** activity is negatively ***regulated*** by ***Sab*** , the Btk-SH3 domain-binding protein .	negative	1
3129	10339592	3700;1234	gp120;CCR5	Substitution of the 8x V3 loop with that from the R5 virus strain BaL resulted in an Env ( 8x-V3BaL ) that mediated CD4-independent CCR5-dependent virus infection and a ***gp120*** that ***bound*** to ***CCR5*** in the absence of CD4 .	parallel	1
3130	10339592	30816;3700	Env;gp120	Substitution of the 8x V3 loop with that from the R5 virus strain BaL resulted in an ***Env*** ( 8x-V3BaL ) that ***mediated*** CD4-independent CCR5-dependent virus infection and a ***gp120*** that bound to CCR5 in the absence of CD4 .	target	0
3131	10339615	10681;9628	Gbeta5;RGS6	When RGS6 is coexpressed with different Gbeta subunits , only ***RGS6*** and ***Gbeta5*** ***interact*** .	parallel	1
3132	10339621	4881;10488	NPR1;basic leucine zipper protein	***Interaction*** of ***NPR1*** with ***basic leucine zipper protein*** transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene .	parallel	1
3133	10339667	7124;1017	TNF-alpha;cdk2	***TNF-alpha*** ***reduced*** the expression of the cyclin ***E-cdk2*** complex .	negative	1
3134	10339667	1019;595	cdk4;cyclin D1	TNF-alpha did not affect the amount of cyclin D1 , cyclin E , cdk4 , cdk2 , and of ******cyclin D1-cdk4****** ***complex*** .	parallel	1
3135	10339667	3569;1026	IL-6;p21	***IL-6*** ***decreased*** ***p21*** expression and its complex with cdk2 , while it increased the cyclin E-cdk2 complex .	negative	0
3136	10339669	885;4318	CCK;MMP-9	These results suggest that ***CCK*** may ***regulate*** the invasiveness and the production of ***MMP-9*** via protein kinase C in human pancreatic cancer cell lines .	target	1
3137	10339675	3084;2065	Hrg;erbB-3	***Hrg*** beta1 treatment ***enhanced*** only ***erbB-3*** tyrosine phosphorylation ; however , the addition of Hrg in low serum did not stimulate ovarian cell growth , unlike all three breast cancer cell lines examined .	positive	0
3138	10340301	2891;9463	GluR2;PICK1	The PDZ domain of PICK1 is required for the interaction and the mutation of a single amino acid in this region ( Lys-27 to Glu ) prevents ***interaction*** between ***PICK1*** and ***GluR2*** in the yeast two-hybrid assay .	parallel	1
3139	10340301	9463;5578	PICK1;PKC alpha	A similar mutation has been reported to prevent the ***binding*** of ***PICK1*** to ***PKC alpha*** indicating that the same domain of PICK1 binds both PKC alpha and GluRs .	parallel	1
3140	10340301	9463;124454	PICK1;GluRs	A similar mutation has been reported to prevent the binding of PICK1 to PKC alpha indicating that the same domain of ***PICK1*** ***binds*** both PKC alpha and ***GluRs*** .	parallel	1
3141	10340301	9463;5578	PICK1;PKC alpha	A similar mutation has been reported to prevent the binding of PICK1 to PKC alpha indicating that the same domain of ***PICK1*** ***binds*** both ***PKC alpha*** and GluRs .	parallel	1
3142	10340301	2891;9463	GluR2;PICK1	Recombinant full length ***GluR2*** is ***coimmunoprecipitated*** with ***flag-PICK1*** using an anti-flag antibody and flag-PICK1 is coimmunoprecipitated with an N-terminal directed anti-GluR2 antibody .	parallel	1
3143	10340386	3725;203074	c-Jun;TSP1	We now demonstrate that the ***c-Jun-induced*** ***repression*** of ***TSP1*** does not occur directly and does not require binding of c-Jun to the TSP1 promoter .	negative	1
3144	10340386	3725;203074	c-Jun;TSP1	We now demonstrate that the c-Jun-induced repression of TSP1 does not occur directly and does not require ***binding*** of ***c-Jun*** to the ***TSP1*** promoter .	parallel	1
3145	10340394	1435;2056	Colony-stimulating factor-1;erythropoietin	***Colony-stimulating factor-1*** ***impairs*** both proliferation and differentiation signals of ***erythropoietin*** during the commitment of bipotential NFS-60 cell line to the monocytic lineage .	negative	0
3146	10340468	116;1621	PACAP;DBH	Taken together , the data suggests that ***PACAP*** is involved in the ***regulation*** of maintenance of the catecholamine synthesizing enzymes TH and ***DBH*** by utilizing the cAMP/PKA pathway .	target	1
3147	10340512	1394;1392	CRF1;corticotropin-releasing factor	Two different ***corticotropin-releasing factor*** ( CRF ) ***receptors*** , ***CRF1*** and CRF2 , have been identified in rat and human brain .	parallel	1
3148	10340512	1395;1392	CRF2;corticotropin-releasing factor	Two different ***corticotropin-releasing factor*** ( CRF ) ***receptors*** , CRF1 and ***CRF2*** , have been identified in rat and human brain .	parallel	1
3149	10340542	970;939	CD70;CD27	***CD70*** , a ***ligand*** of the T cell costimulatory receptor ***CD27*** , is expressed mainly on activated B cells and has been shown to increase cytotoxic activity and proliferation of preferentially unprimed T cells .	parallel	1
3150	10340552	4632;3630	myosin-light chain 1;proinsulin	Thus , C2C12 mouse myoblast cells were stably transfected with a chimeric gene obtained by ***linking*** the ***myosin-light chain 1*** ( MLC1 ) promoter to the human ***proinsulin*** gene , containing genetically engineered furin endoprotease cleavage sites ( MLC1/Insm ) .	parallel	0
3151	10340753	7422;2321	VEGF;VEGFR-1	Vascular endothelial growth factor B ( ***VEGF-B*** ) is structurally closely related to VEGF and ***binds*** one of its receptors , ***VEGFR-1*** .	parallel	1
3152	10340755	6469;5727	Shh;Ptc	However , in Msx1 mutant dental mesenchyme Shh-soaked beads were able to induce Gli1 but failed to induce Ptc expression , indicating a requirement for Msx1 in the ***induction*** of ***Ptc*** by ***Shh*** .	target	1
3153	10340755	652;5727	BMP4;Ptc	Moreover , we show that another signaling molecule , ***BMP4*** , was able to ***induce*** ***Ptc*** expression in wild-type dental mesenchyme , but induced a distinct expression pattern of Ptc in the Msx1 mutant molar mesenchyme .	target	1
3154	10340760	3569;627	IL-6;neurotrophin	In summary , our results indicate that ***IL-6*** in conjunction with sIL-6R ***regulates*** specific ***neurotrophin*** expression in astrocytes in a brain region dependent manner .	target	1
3155	10340812	7124;3952	TNFalpha;leptin	CONCLUSIONS : Our results are consistent with the hypothesis that the ***TNFalpha*** system could be involved in the ***regulation*** of plasma ***leptin*** concentrations in obese subjects .	target	1
3156	10340821	5443;551	ACTH;arginine vasopressin	***ACTH*** and cortisol ***response*** to combined ***corticotropin releasing hormone-arginine vasopressin*** stimulation in obese males and its relationship to body weight , fat distribution and parameters of the metabolic syndrome .	parallel	0
3157	10340821	5443;1392	ACTH;corticotropin releasing hormone	***ACTH*** and cortisol ***response*** to combined ***corticotropin releasing hormone-arginine vasopressin*** stimulation in obese males and its relationship to body weight , fat distribution and parameters of the metabolic syndrome .	parallel	0
3158	10340949	5879;5599	Rac1;JNK	In contrast , expression of a constitutively active Rac1 , an alternative guanosine triphosphatase involved in intracellular signaling , produced a high level of JNK1 activation , suggesting that ***Rac1*** is an important upstream ***activator*** of ***JNK*** in this system .	positive	1
3159	10340949	6416;5599	SEK1;JNK	Active Ras and MAPK/ ERK kinase-1 ( MEK1 ) ( the upstream activator of ERK ) each induced cyclin D1 promoter activity , whereas active stress-activated protein kinase/ERK kinase-1 ( ***SEK1*** ) , an upstream ***activator*** of ***JNK*** , did not .	positive	1
3160	10340964	959;958	CD40L;CD40	OBJECTIVE : The expression of CD40 and ***CD40*** ***ligand*** ( ***CD40L*** ) in mononuclear cells ( MNCs ) infiltrating the salivary glands of patients with Sjögren 's syndrome ( SS ) has recently been reported .	parallel	1
3161	10340997	5104;5327	PCI;tPA	Similarly , > 90 % of ******PCI-tPA****** ***complex*** was formed after 30 min of heparin stimulation in normal seminal plasma but no response was observed in the two patient samples .	parallel	1
3162	10341084	9173;4602	fit-1;MYB	The ***fit-1*** common integration locus in human and mouse is closely ***linked*** to ***MYB*** .	parallel	0
3163	10341204	3553;2252	IL-1;KGF	These data indicate a regulation of keratinocyte growth by a double paracrine mechanism through release of ***IL-1*** which ***induces*** ***KGF*** in cocultured fibroblasts .	target	1
3164	10341227	5663;1499	PS1;beta-catenin	Here , we show that both the full length and the C-terminal fragment of wild-type or FAD mutant ***PS1*** ***interact*** with ***beta-catenin*** from transfected cells and brains of transgenic mice , whereas E-cadherin and adenomatous polyposis coli ( APC ) are not detected in this complex .	parallel	1
3165	10341227	2932;1499	GSK-3beta;beta-catenin	Inducible overexpression of PS1 led to increased association of beta-catenin with glycogen synthase kinase-3beta ( ***GSK-3beta*** ) , a negative ***regulator*** of ***beta-catenin*** , and accelerated the turnover of endogenous beta-catenin .	negative	1
3166	10341227	1499;2932	beta-catenin;GSK-3beta	Inducible overexpression of PS1 led to increased ***association*** of ***beta-catenin*** with glycogen synthase kinase-3beta ( ***GSK-3beta*** ) , a negative regulator of beta-catenin , and accelerated the turnover of endogenous beta-catenin .	parallel	0
3167	10341227	5663;1499	PS1;beta-catenin	In support of this finding , the beta-catenin half-life was dramatically longer in fibroblasts deficient in PS1 , and this phenotype was completely rescued by replacement of PS1 , demonstrating that ***PS1*** normally ***stimulates*** the degradation of ***beta-catenin*** .	positive	0
3168	10341227	1499;2932	beta-catenin;GSK-3beta	In contrast , overexpression of FAD-linked PS1 mutants ( M146L and DeltaX9 ) failed to enhance the ***association*** between ***GSK-3beta*** and ***beta-catenin*** and interfered with the constitutive turnover of beta-catenin .	parallel	0
3169	10341227	5663;1499	PS1;beta-catenin	In vivo confirmation was demonstrated in the brains of transgenic mice in which the expression of the M146L mutant ***PS1*** was ***correlated*** with increased steady-state levels of endogenous ***beta-catenin*** .	parallel	0
3170	10341227	1499;5663	beta-catenin;PS1	Thus , our results indicate that PS1 normally promotes the turnover of beta-catenin , whereas PS1 mutants partially interfere with this process , possibly by failing to recruit GSK-3beta into the ******PS1-beta-catenin****** ***complex*** .	parallel	1
3171	10341227	1499;5663	beta-catenin;PS1	These findings raise the intriguing possibility that ******PS1-beta-catenin****** ***interactions*** and subsequent activities may be consequential for the pathogenesis of AD .	parallel	1
3172	10341229	5803;7143	phosphacan;TN-R	However , immunostaining for the chondroitin sulfate proteoglycan ***phosphacan*** , a high-affinity ***ligand*** for ***TN-R*** , is weak and diffuse in the mutant when compared with wild-type mice .	parallel	1
3173	10341341	7832;29883	BTG2;CAF1	***BTG2*** protein physically ***interacts*** with the protein ***CAF1*** , an element of a general transcription complex , and with a protein-arginine N-methyl transferase , PRMT1 .	parallel	1
3174	10341341	7832;3276	BTG2;PRMT1	***BTG2*** protein physically ***interacts*** with the protein CAF1 , an element of a general transcription complex , and with a protein-arginine N-methyl transferase , ***PRMT1*** .	parallel	1
3175	10341737	3623;213	inhibin alpha-subunit;albumin	In Expt 1 , during the breeding season , 30 ewes were subdivided into three groups : group I served as the non-immunized control ; group II was immunized against inhibin-like peptide ( 100 micrograms inhibin-like peptide equivalent , followed by three booster injections ) ; group III was immunized against pig ***inhibin alpha-subunit*** ***conjugated*** to human serum ***albumin*** ( 96 micrograms for the primary administration and 46 micrograms for the booster ) .	parallel	1
3176	10341860	5443;1392	POMC;CRH	In contrast , plasma ***POMC*** positively ***correlated*** with plasma ***CRH*** .	positive	0
3177	10342332	847;176	Catalase;Aggrecan	***Catalase*** significantly ***prevented*** the release of labeled ***Aggrecan*** in LPS-chondrocyte cultures , suggesting a role for chondrocyte-derived hydrogen peroxide in Aggrecan degradation .	negative	0
3178	10342375	3791;7422	KDR;VEGF	We investigated the transcription of ***VEGF*** and its ***receptor*** ***KDR/flk-1*** genes during the development of experimentally induced choroidal neovascularization .	parallel	1
3179	10342375	3791;7422	KDR;VEGF	CONCLUSIONS : Our findings demonstrate that expression of ***VEGF*** and its ***receptor*** ***KDR*** may play a role in the formation of experimentally induced choroidal neovascularization .	parallel	1
3180	10342402	4803;4852	NGF;NPY	The results of our studies show : ( a ) that NGF is present in the brain of these birds and it is higher in the HVC than in the other neostriatal tissues ; ( b ) that exogenous administration of NGF or NGF-antibody had no discernible effect on singing behavior ; and ( c ) that ***NGF*** ***enhances*** the ***NPY*** immunoreactivity in neurons and fibers localized in HVC and other areas of the neostriatum and hippocampus whereas anti-NGF decreased NPY stained cells in the hippocampus .	positive	0
3181	10342487	7040;4843	TGF-beta1;NOS2	These findings suggest that the ***interaction*** between ***TGF-beta1*** and ***NOS2*** might be important for angiogenesis after cerebral ischaemia and may indicate that TGF-beta1 is upregulated as a negative feedback response to elevated levels of NO .	parallel	1
3182	10342807	5465;7352	PPAR-alpha;UCP-3	It is proposed that the ***UCP-3*** gene is predominantly ***regulated*** in neonatal muscle by ***PPAR-alpha*** activation .	target	1
3183	10342810	3645;3667	Insulin receptor-related receptor;insulin receptor substrate-1	***Insulin receptor-related receptor*** is expressed in pancreatic beta-cells and ***stimulates*** tyrosine phosphorylation of ***insulin receptor substrate-1*** and -2 .	positive	0
3184	10342820	5054;213	PAI-1;albumin	Furthermore , ***PAI-1*** activity was positively ***correlated*** with urinary ***albumin*** excretion ( r = 0.48 , P < 0.01 ) and inversely correlated with the vasodilatory response to the highest ACh dose ( r = -0.37 , P < 0.05 ) .	positive	0
3185	10342828	7124;2908	TNF alpha;glucocorticoid receptor	Moreover , ***TNF alpha*** treatment only weakly ***inhibited*** ligand-dependent ***glucocorticoid receptor*** activity in the HOB-03-CE6 cells .	negative	1
3186	10342828	7124;4790	TNF alpha;NF-kappaB	Treatment of the cells with 17beta-E2 partially suppressed the ***activation*** of ***NF-kappaB*** by ***TNF alpha*** , but did not block cytokine-induced IL-6 secretion .	positive	1
3187	10342855	2100;5617	ER beta;PRL	We conclude that 1 ) both ER beta and TERP messenger RNAs in GH3 cells are increased by estradiol in a dose - and time-dependent manner , whereas ER alpha is not altered ; 2 ) a 58-kDa ER beta protein is expressed in both the pituitary and GH3 cells ; and 3 ) overexpression of ***ER beta*** ***increases*** estrogen-induced ***PRL*** gene expression .	positive	0
3188	10342861	2099;5241	ER-alpha;progesterone receptor	The results suggest that the stromal cell sensitivity to decidualization is critically dependent on P4-regulated events , and estrogenic ***induction*** of ***progesterone receptor*** via classical nuclear ***ER-alpha*** is not critical for this process .	target	1
3189	10342875	2691;2692	GHRH;growth hormone-releasing hormone (GHRH) receptor	Differential in vivo ***regulation*** of the pituitary ***growth hormone-releasing hormone (GHRH) receptor*** by ***GHRH*** in young and aged rats .	target	1
3190	10342884	4233;3082	c-Met;HGF	Both of these cells express ***c-Met*** , the ***receptor*** for ***HGF*** .	parallel	1
3191	10343075	5175;3685	PECAM-1;integrin alphavbeta3	As well as mediating homophilic ( PECAM-1/PECAM-1 ) adhesion , ***PECAM-1*** can also ***bind*** the ***integrin alphavbeta3*** .	parallel	1
3192	10344280	4792;4790	IkappaBalpha;NFkappaB	The model used in this study was a human lymphoblastoid cell line in which a functional repression of the transcription factors NFkappaB was obtained by induction of overexpression of ***IkappaBalpha*** , a physiological ***inhibitor*** of ***NFkappaB*** .	negative	1
3193	10344756	3845;3725	Ki-Ras;c-Jun	Activated ***Ki-Ras*** ***suppresses*** 12-O-tetradecanoylphorbol-13-acetate-induced activation of the ***c-Jun*** NH2-terminal kinase pathway in human colon cancer cells .	negative	1
3194	10344757	4605;596	B-Myb;bcl-2	Overexpression of ***B-Myb*** was ***associated*** with enhanced expression of ***bcl-2*** , which was dependent , at least in part , on increased transcription .	parallel	0
3195	10344757	4605;596	B-Myb;bcl-2	In transient transfection assays in T-lymphoblastic cells , ***B-Myb*** was able to ***stimulate*** the promoter activity of the ***bcl-2*** 5 ' flanking region linked to the chloramphenicol acetyltransferase reporter gene .	positive	0
3196	10344759	1029;4193	ARF;Mdm2	***ARF*** ***binds*** directly to ***Mdm2*** to prevent down-regulation of p53 and thereby promotes p53-dependent transcription and cell cycle arrest .	parallel	1
3197	10344759	1029;7157	ARF;p53	***ARF*** binds directly to Mdm2 to ***prevent*** down-regulation of ***p53*** and thereby promotes p53-dependent transcription and cell cycle arrest .	negative	0
3198	10346816	10111;4361	Rad50;Mre11	Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the ******Mre11/Rad50****** ***complex*** .	parallel	1
3199	10346816	4683;4361	Nbs1;Mre11	We show in this work that the triple ***complex*** of recombinant ***Nbs1*** , ***Mre11*** , and Rad50 proteins binds cooperatively to DNA and forms a distinct protein-DNA species .	parallel	1
3200	10346816	10111;4361	Rad50;Mre11	We show in this work that the triple ***complex*** of recombinant Nbs1 , ***Mre11*** , and ***Rad50*** proteins binds cooperatively to DNA and forms a distinct protein-DNA species .	parallel	1
3201	10346816	10111;4683	Rad50;Nbs1	We show in this work that the triple ***complex*** of recombinant ***Nbs1*** , Mre11 , and ***Rad50*** proteins binds cooperatively to DNA and forms a distinct protein-DNA species .	parallel	1
3202	10346816	4683;4361	Nbs1;Mre11	The ******Mre11/Rad50/Nbs1****** ***complex*** displays several enzymatic activities that are not seen without Nbs1 , including partial unwinding of a DNA duplex and efficient cleavage of fully paired hairpins .	parallel	1
3203	10346816	10111;4361	Rad50;Mre11	The ******Mre11/Rad50/Nbs1****** ***complex*** displays several enzymatic activities that are not seen without Nbs1 , including partial unwinding of a DNA duplex and efficient cleavage of fully paired hairpins .	parallel	1
3204	10346816	10111;4683	Rad50;Nbs1	The ******Mre11/Rad50/Nbs1****** ***complex*** displays several enzymatic activities that are not seen without Nbs1 , including partial unwinding of a DNA duplex and efficient cleavage of fully paired hairpins .	parallel	1
3205	10346818	7186;5599	TRAF2;JNK	Overexpressed ***TRAF2*** or TRAF6 ***activate*** ***JNK*** , p38 , or IKK in the absence of extracellular stimulation .	positive	1
3206	10346818	7186;5594	TRAF2;p38	Overexpressed ***TRAF2*** or TRAF6 ***activate*** JNK , ***p38*** , or IKK in the absence of extracellular stimulation .	positive	1
3207	10346818	7189;5599	TRAF6;JNK	Overexpressed TRAF2 or ***TRAF6*** ***activate*** ***JNK*** , p38 , or IKK in the absence of extracellular stimulation .	positive	1
3208	10346818	7189;5594	TRAF6;p38	Overexpressed TRAF2 or ***TRAF6*** ***activate*** JNK , ***p38*** , or IKK in the absence of extracellular stimulation .	positive	1
3209	10346818	7186;4214	TRAF2;MEKK1	TNF-alpha also enhances the ***binding*** of native ***TRAF2*** to ***MEKK1*** and stimulates the kinase activity of the latter .	parallel	1
3210	10346818	7124;7186	TNF-alpha;TRAF2	***TNF-alpha*** also ***enhances*** the binding of native ***TRAF2*** to MEKK1 and stimulates the kinase activity of the latter .	positive	0
3211	10346929	3700;920	gp120;CD4	The anti-HIV agent cosalane inhibits both the ***binding*** of ***gp120*** to ***CD4*** as well as an undefined postattachment event prior to reverse transcription .	parallel	1
3212	10347092	1998;7010	NERF2;Tie2	***NERF2*** can ***bind*** to the ***Tie2*** promoter Ets sites in electrophoretic mobility shift assays .	parallel	1
3213	10347094	7422;5747	Vascular endothelial growth factor;p125FAK	***Vascular endothelial growth factor*** ***induces*** activation and subcellular translocation of focal adhesion kinase ( ***p125FAK*** ) in cultured rat cardiac myocytes .	target	1
3214	10347094	3791;7422	Flk-1;VEGF	We found that the 2 ***VEGF*** ***receptors*** , ***KDR/Flk-1*** and Flt-1 , were expressed in cardiac myocytes and that KDR/Flk-1 was significantly tyrosine phosphorylated on VEGF stimulation .	parallel	1
3215	10347094	2321;7422	Flt-1;VEGF	We found that the 2 ***VEGF*** ***receptors*** , KDR/Flk-1 and ***Flt-1*** , were expressed in cardiac myocytes and that KDR/Flk-1 was significantly tyrosine phosphorylated on VEGF stimulation .	parallel	1
3216	10347113	3482;3481	M6P/IGF2R;insulin-like growth factor 2	Failure to detect genetic alteration of the mannose-6-phosphate / ***insulin-like growth factor 2*** ***receptor*** ( ***M6P/IGF2R*** ) gene in hepatocellular carcinomas in Japan .	parallel	1
3217	10347113	3482;3481	M6P/IGF2R;insulin-like growth factor 2	The mannose-6-phosphate / ***insulin-like growth factor 2*** ***receptor*** ( ***M6P/IGF2R*** ) suppresses cell growth through binding to the insulin-like growth factor 2 ( IGF2 ) and latent complex of the transforming growth factor-beta ( TGF-beta ) .	parallel	1
3218	10347117	3479;5594	IGF-1;ERK	Insulin and IGF-1 induced 70-kd S6 kinase phosphorylation in HSC , whereas ***IGF-1*** only ***induced*** ***ERK*** phosphorylation .	target	1
3219	10347160	7186;4790	TRAF2;NF-kappaB	Divergence of signals must , however , occur downstream of TRAF2 as a dominant negative ***TRAF2*** mutant that ***blocks*** LMP1-induced ***NF-kappaB*** activation also inhibited p38 signaling .	positive	0
3220	10347163	4436;2956	MSH2;MSH6	A mutation in the MSH6 subunit of the Saccharomyces cerevisiae ******MSH2-MSH6****** ***complex*** disrupts mismatch recognition .	parallel	1
3221	10347163	4436;2956	MSH2;MSH6	In yeast , ***MSH2*** ***interacts*** with ***MSH6*** to repair base pair mismatches and single nucleotide insertion/deletion mismatches and with MSH3 to recognize small loop insertion/deletion mismatches .	parallel	1
3222	10347163	4436;2956	MSH2;MSH6	In UV cross-linking , filter binding , and gel retardation assays , the ******MSH2-MSH6-F337A****** ***complex*** displayed a mismatch recognition defect .	parallel	1
3223	10347163	4436;2956	MSH2;MSH6	These observations , in conjunction with ATPase and dissociation rate analysis , suggested that ******MSH2-MSH6-F337A****** formed an unproductive ***complex*** that was unable to stably bind to mismatch DNA .	parallel	1
3224	10347167	8031;5468	ARA70;PPARgamma	Thus , ***ARA70*** can function as a ligand-enhanced ***coactivator*** of ***PPARgamma*** .	positive	1
3225	10347175	3937;7409	SLP-76;Vav	Surprisingly , we find also that the ***interaction*** between ***SLP-76*** and ***Vav*** is not required for their cooperation in augmenting IL-2 promoter activity , as the two molecules appear to function in different signaling pathways upstream of IL-2 gene expression .	parallel	1
3226	10347175	7409;3558	Vav;IL-2	Additionally , overexpression of ***Vav*** , but not SLP-76 , ***augments*** CD28-induced ***IL-2*** promoter activity .	positive	0
3227	10347184	7514;5902	Crm1;RanBP1	Second , RanBP1 ( or homologous proteins ) can displace Nup and form a ternary ******RanBP1/RanGTP/Crm1****** ***complex*** that can be disassembled by RanGAP via GTP hydrolysis .	parallel	1
3228	10347185	3576;3577	interleukin-8;CXCR1	While ***interleukin-8*** stimulation ***promoted*** ***CXCR1*** sequestration in RBL-2H3 cells , receptor internalization in HEK 293 cells required co-expression of G protein-coupled receptor kinase 2 and beta-arrestin proteins .	positive	0
3229	10347188	10845;8192	ClpX;ClpP	Recombinant ***ClpX*** can also ***interact*** with its putative partner protease subunit ***ClpP*** in overexpression experiments in 293T cells .	parallel	1
3230	10347196	10847;1387	SRCAP;CREB-binding protein	Identification of a novel SNF2/SWI2 protein family member , ***SRCAP*** , which ***interacts*** with ***CREB-binding protein*** .	parallel	1
3231	10347206	3350;820	5-HT1A;cAMP	Thus , ***5-HT1A*** and muscarinic M4 receptor may couple dominantly to Galphai1 and Galphai3 , respectively , to ***inhibit*** ***cAMP*** production .	negative	1
3232	10347209	5579;7299	PKC-beta;tyrosinase	We conclude that ***PKC-beta*** ***activates*** ***tyrosinase*** directly by phosphorylating serine residues at positions 505 and 509 in the cytoplasmic domain of this melanosome-associated protein .	positive	1
3233	10347209	5579;7299	Protein kinase C-beta;tyrosinase	***Protein kinase C-beta*** ***activates*** ***tyrosinase*** by phosphorylating serine residues in its cytoplasmic domain .	positive	1
3234	10347209	5579;7299	PKC-beta;tyrosinase	By immunoelectron microscopy , ***PKC-beta*** but not PKC-alpha was closely ***associated*** with ***tyrosinase*** on the outer surface of melanosomes .	parallel	0
3235	10347209	5579;7299	PKC-beta;tyrosinase	Only the cytoplasmic ( extra-melanosomal ) domain of ***tyrosinase*** , which contains two serines but no threonines , was ***phosphorylated*** by the serine/threonine kinase ***PKC-beta*** .	target	1
3236	10347215	3586;3716	IL-10;Jak1	Herein , we demonstrate that the ability of ***IL-10*** to inhibit tumor necrosis factor alpha ( TNFalpha ) production in lipopolysaccharide-stimulated macrophages ***requires*** the presence of Stat3 , ***Jak1*** , and two distinct regions of the IL-10 receptor intracellular domain .	target	0
3237	10347215	3586;6774	IL-10;Stat3	Herein , we demonstrate that the ability of ***IL-10*** to inhibit tumor necrosis factor alpha ( TNFalpha ) production in lipopolysaccharide-stimulated macrophages ***requires*** the presence of ***Stat3*** , Jak1 , and two distinct regions of the IL-10 receptor intracellular domain .	target	0
3238	10347215	3586;7124	IL-10;TNFalpha	These results thus demonstrate that ***IL-10-induced*** ***inhibition*** of ***TNFalpha*** production requires two distinct regions of the IL-10 receptor intracellular domain and thereby establish a distinctive molecular basis for the developmental versus the anti-inflammatory actions of IL-10 .	negative	1
3239	10347217	4193;7157	MDM2;p53	Oligomerization is required for ***p53*** to be efficiently ***ubiquitinated*** by ***MDM2*** .	target	1
3240	10347217	4193;7157	MDM2;p53	Recent studies indicate that ***MDM2*** can ***bind*** ***p53*** and promote its rapid degradation although the molecular basis for this degradation has not been clarified .	parallel	1
3241	10347217	4193;7157	MDM2;p53	This report demonstrates that ***MDM2*** can ***promote*** the ubiquitination of wild-type ***p53*** and cancer-derived p53 mutants in transiently transfected cells .	positive	0
3242	10347217	4193;7157	MDM2;p53	These results indicate that oligomerization is required for ***p53*** to efficiently bind and be ***ubiquitinated*** by ***MDM2*** .	target	1
3243	10347227	4215;9261	MEKK3;MAPKAPK2	Anisomycin , sorbitol , or the expression of ***MEKK3*** in HEK293 cells ***enhanced*** ***MAPKAPK2*** phosphorylation , whereas MEKK2 was less effective .	positive	0
3244	10347227	4215;5608	MEK kinase 3;MKK6	***MEK kinase 3*** directly ***activates*** ***MKK6*** and MKK7 , specific activators of the p38 and c-Jun NH2-terminal kinases .	positive	1
3245	10347227	4215;5609	MEK kinase 3;MKK7	***MEK kinase 3*** directly ***activates*** MKK6 and ***MKK7*** , specific activators of the p38 and c-Jun NH2-terminal kinases .	positive	1
3246	10347227	10746;5608	MEKK2;MKK6	***MEKK2*** , a closely related homologue of MEKK3 , also ***activated*** MKK7 and ***MKK6*** in COS-7 cells .	positive	1
3247	10347227	10746;5609	MEKK2;MKK7	***MEKK2*** , a closely related homologue of MEKK3 , also ***activated*** ***MKK7*** and MKK6 in COS-7 cells .	positive	1
3248	10347229	5159;867	PDGFRbeta;Cbl	Here , we show that , similar to PDGFRalpha , selective stimulation of ***PDGFRbeta*** ***induces*** ***Cbl*** phosphorylation , and its physical association with the receptor .	target	1
3249	10347244	185;183	AT1;angiotensin II	Relationship between internalization and mRNA decay in down-regulation of recombinant type 1 ***angiotensin II*** ***receptor*** ( ***AT1*** ) expression in smooth muscle cells .	parallel	1
3250	10347244	185;183	AT1;angiotensin II	In vascular smooth muscle cells , the hormone angiotensin II is thought to cause internalization of the seven-transmembrane domain type 1 ***angiotensin II*** ***receptor*** ( ***AT1-R*** ) but it also suppresses expression of the receptor mRNA .	parallel	1
3251	10347248	10203;796	calcitonin receptor-like receptor;calcitonin	The ***calcitonin receptor-like receptor*** ( CRLR ) can function as either a ***receptor*** for ***calcitonin*** gene-related peptide ( CGRP ) or for adrenomedullin ( ADM ) , depending upon the coexpression of a novel family of single transmembrane proteins , which we have called receptor activity modifying proteins or RAMPs .	parallel	1
3252	10348340	3558;6774	IL-2;STAT3	***IL-2*** ***induced*** the DNA binding activity of ***STAT3*** and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation .	target	1
3253	10348343	7157;5610	p53;PKR	These novel findings raise the possibility of a functional ***interaction*** between ***PKR*** and ***p53*** in vivo , which may account , at least in part , for the ability of each protein to regulate gene expression at both the transcriptional and the translational levels .	parallel	1
3254	10348343	5610;7157	PKR;p53	The double-stranded RNA activated protein kinase ***PKR*** physically ***associates*** with the tumor suppressor ***p53*** protein and phosphorylates human p53 on serine 392 in vitro .	parallel	0
3255	10348343	5610;7157	PKR;p53	The double-stranded RNA activated protein kinase ***PKR*** physically associates with the tumor suppressor p53 protein and ***phosphorylates*** human ***p53*** on serine 392 in vitro .	target	1
3256	10348343	5610;7157	PKR;p53	Here we report that ***PKR*** physically ***associates*** with ***p53*** .	parallel	0
3257	10348343	5610;7157	PKR;p53	The ***interaction*** of ***PKR*** with ***p53*** is enhanced by IFNs and upon conditions that p53 acquires a wild type conformation .	parallel	1
3258	10348343	7157;5610	p53;PKR	***PKR/p53*** complex formation in vitro ***requires*** the N-terminal regulatory domain of ***PKR*** and the last 30 amino acids of the C-terminus of human p53 .	target	0
3259	10348343	7157;5610	p53;PKR	In addition , ***p53*** may function as a ***substrate*** of ***PKR*** since phosphorylation of human p53 on serine392 is induced by activated PKR in vitro .	parallel	1
3260	10348346	595;1017	cyclin D1;cdk2	The expression of cyclin A ( a regulatory subunit of cdk2 ) markedly decreased , while ***cyclin D1*** , the major cdk4 partner in fibroblasts , expressed at a slightly higher level and formed ***complexes*** with ***cdk2*** and cdk6 in addition to cdk4 .	parallel	1
3261	10348346	595;1021	cyclin D1;cdk6	The expression of cyclin A ( a regulatory subunit of cdk2 ) markedly decreased , while ***cyclin D1*** , the major cdk4 partner in fibroblasts , expressed at a slightly higher level and formed ***complexes*** with cdk2 and ***cdk6*** in addition to cdk4 .	parallel	1
3262	10348346	1029;7157	p19ARF;p53	Induction of ***p19ARF*** ***activated*** ***p53*** by increasing its stability , and allowed the expression of p21Cip1 , which bound to all of the cyclin D1-cdk complexes ( cyclin D1-cdk2 , - cdk4 , and - cdk6 ) thereby inhibiting their kinase activities .	positive	1
3263	10348349	1630;836	DCC;caspase-3	In the present study , we demonstrated that expression of ***DCC*** ***activated*** ***caspase-3*** and programmed cell death , or induced G2/M cell cycle arrest in tumor cells .	positive	1
3264	10348828	7039;5595	TGF-alpha;ERK1	RESULTS : ***TGF-alpha*** ***stimulated*** activation of ***ERK1*** / -2 , which was dependent on MEK-1 , but independent of PKC activity .	positive	0
3265	10349617	8928;7040	Fast1;TGF beta	We propose that mouse ***Fast1*** , like Xenopus FAST-1 , ***mediates*** ***TGF beta*** superfamily signals specifying developmental fate during early embryogenesis .	target	0
3266	10349699	6351;5617	CCl4;PRL	Serum ***PRL*** levels were ***reduced*** by E + or ***CCl4*** on all 3 dates of PRL evaluation .	negative	1
3267	10349800	3952;1588	Leptin;aromatase	***Leptin*** ***regulation*** of ***aromatase*** activity in adipose stromal cells from regularly cycling women .	target	1
3268	10349800	3952;1588	Leptin;aromatase	The aromatase gene promoter in adipose stromal cells contains a functional STAT binding region , leading to the hypothesis that ***Leptin*** may ***regulate*** ***aromatase*** activity in fat tissue .	target	1
3269	10349817	5328;5329	uPA;uPAR	Particular attention has been given to the effects of plasmin proteolysis which is generated in the extracellular matrix by urokinase plasminogen activator ( ***uPA*** ) ***complexed*** with its receptor ( ***uPAR*** ) .	parallel	1
3270	10349838	4803;836	NGF;caspase-3	***NGF*** ***regulated*** several members of the bcl-2 family and ***caspase-3*** in a manner consistent with its effect on apoptosis in PC12 cells .	target	1
3271	10349838	4803;598	NGF;bcl-xs	Levels of bcl-xl , ***bcl-xs*** , and caspase-3 mRNAs were ***increased*** by ***NGF*** treatment .	positive	0
3272	10349844	3458;3162	interferon-gamma;heme oxygenase-1	***Suppression*** of ***heme oxygenase-1*** mRNA expression by ***interferon-gamma*** in human glioblastoma cells .	negative	1
3273	10349844	3458;3162	interferon-gamma;heme oxygenase-1	These findings raise the possibility that the expression of ***heme oxygenase-1*** is ***down-regulated*** by ***interferon-gamma*** in the nervous system .	negative	1
3274	10349867	831;5579	calpain inhibitor;PKC-beta	A ***calpain inhibitor*** , acetylleucylleucylnorleucinal , ***inhibited*** the down-regulation of ***PKC-beta*** , through intravenous injection .	negative	1
3275	10349994	7248;7249	hamartin;tuberin	This is consistent with the recent finding that ***tuberin*** and ***hamartin*** ***interact*** and with the clinical similarity between TSC1 - and TSC2-linked disease .	parallel	1
3276	10350046	5609;6777	MEK;Stat5b	***MEK*** is a negative ***regulator*** of ***Stat5b*** in PDGF-stimulated cells .	negative	1
3277	10350046	5609;6777	MEK;Stat5b	These observations indicate that ***MEK*** is a negative ***modulator*** of PDGF-induced ***Stat5b*** activation through a mechanism not involving direct phosphorylation of Stat5b .	negative	0
3278	10350061	5335;5781	PLC-gamma1;SHP-2	Using two phosphopeptides , NSDVQpY663TEVQV and DTETVpY686SEVRK , we demonstrate differential ***binding*** of SHP-1 , ***SHP-2*** , SHIP and ***PLC-gamma1*** .	parallel	1
3279	10350210	983;55968	p34cdc2;p47	***Phosphorylation*** of p97 ( VCP ) and ***p47*** in vitro by ***p34cdc2*** kinase .	target	1
3280	10350210	983;7415	p34cdc2;p97	***Phosphorylation*** of ***p97*** ( VCP ) and p47 in vitro by ***p34cdc2*** kinase .	target	1
3281	10350210	983;7415	p34cdc2;p97	Monomeric , but not hexameric , ***p97*** was ***phosphorylated*** by ***p34cdc2*** kinase , as was the p97-associated protein p47 .	target	1
3282	10350216	4926;636	structural nuclear protein;BICD	In a yeast two-hybrid screen we identified an ***interaction*** between Drosophila lamin Dm0 , a ***structural nuclear protein*** , and ***BICD*** , a protein involved in oocyte development .	parallel	1
3283	10350489	2745;5770	thioltransferase;PTP1B	In addition , inactivated ***PTP1B*** is ***reactivated*** enzymatically by the glutathione-specific dethiolase enzyme ***thioltransferase*** ( glutaredoxin ) , indicating that the inactivated form of the phosphatase is a glutathionyl mixed disulfide .	positive	1
3284	10350617	1956;5335	EGFR;PLC-gamma1	The ***EGFR*** specifically ***activates*** phospholipase C-gamma1 ( ***PLC-gamma1*** ) .	positive	1
3285	10350623	1369;3827	kininase I;Bradykinin	Furthermore , the cortex homogenate expresses a ***kininase I*** activity that ***cleaves*** ***Bradykinin*** to des-Arg9-Bradykinin .	target	1
3286	10350644	2033;1387	p300;CBP	Mammalian two hybrid assays indicated that the ***interaction*** between C/ATF and ******CBP/p300****** can occur in mammalian cells , and that the p300 CH1 domain is critical for the interaction .	parallel	1
3287	10350652	2950;2729	GSTP1;GCS	GSH homeostasis thus appears to be maintained by an ***interaction*** between ***GSTP1*** and ***GCS*** in human hepatic cells resistant to the GSH poison .	parallel	1
3288	10351940	6037;6348	ECP;MIP-1-alpha	Eosinophil cationic protein ( ECP ) and eosinophil-derived neurotoxin ( EDN ) , the eosinophil secretory ribonucleases , were detected in lower airway secretions from RSV-infected patients ; ***ECP*** concentrations ***correlated*** with ***MIP-1-alpha*** concentrations ( r = 0.93 ) .	parallel	0
3289	10352239	3558;4915	IL-2;trkB	The Th1 cytokine ***IL-2*** ***stimulated*** production of ***trkB*** mRNA but not of trkC , whereas the Th2 cytokine IL-4 enhanced NT-3 but not BDNF mRNA expression .	positive	0
3290	10352239	3558;4916	IL-2;trkC	The Th1 cytokine ***IL-2*** ***stimulated*** production of trkB mRNA but not of ***trkC*** , whereas the Th2 cytokine IL-4 enhanced NT-3 but not BDNF mRNA expression .	positive	0
3291	10352240	7186;958	TRAF2;CD40	We find that ***binding*** of ***TRAF2*** and TRAF3 to ***CD40*** is not required for the induction of Ab secretion , but that both TRAF molecules can regulate the activation process .	parallel	1
3292	10352240	7187;958	TRAF3;CD40	We find that ***binding*** of TRAF2 and ***TRAF3*** to ***CD40*** is not required for the induction of Ab secretion , but that both TRAF molecules can regulate the activation process .	parallel	1
3293	10352242	3439;596	IFN-alpha;Bcl-2	Instead , ***IFN-alpha*** and IFN-beta , but not IFN-gamma , significantly ***increase*** the levels of the survival protein ***Bcl-2*** , and to a lesser extent , Bcl-xL expression .	positive	0
3294	10352242	3456;596	IFN-beta;Bcl-2	Instead , IFN-alpha and ***IFN-beta*** , but not IFN-gamma , significantly ***increase*** the levels of the survival protein ***Bcl-2*** , and to a lesser extent , Bcl-xL expression .	positive	0
3295	10352244	6693;3586	CD43;IL-10	In parallel , ***CD43*** cross-linking ***induced*** synthesis and release of IL-1beta , IL-6 , TNF-alpha , IL-12 , and ***IL-10*** .	target	1
3296	10352244	6693;3553	CD43;IL-1beta	In parallel , ***CD43*** cross-linking ***induced*** synthesis and release of ***IL-1beta*** , IL-6 , TNF-alpha , IL-12 , and IL-10 .	target	1
3297	10352244	6693;3569	CD43;IL-6	In parallel , ***CD43*** cross-linking ***induced*** synthesis and release of IL-1beta , ***IL-6*** , TNF-alpha , IL-12 , and IL-10 .	target	1
3298	10352244	6693;7124	CD43;TNF-alpha	In parallel , ***CD43*** cross-linking ***induced*** synthesis and release of IL-1beta , IL-6 , ***TNF-alpha*** , IL-12 , and IL-10 .	target	1
3299	10352245	356;355	CD95L;CD95	Two distinct forms of short-term cytolysis have been described for CD8 + CTLs , the perforin/granzyme - and Fas ligand/Fas ( ***CD95*** ***ligand*** ( ***CD95L*** ) / CD95 ) - mediated pathways .	parallel	1
3300	10352248	356;355	Fas ligand;Fas	Thus , the increased sensitivity of mev T cells to apoptosis following TCR restimulation appears to reflect a TCR-driven phenomenon mediated through up-regulation of ******Fas-Fas ligand****** ***interaction*** and induction of the Fas signaling cascade .	parallel	1
3301	10352257	959;958	CD40L;CD40	In the APC-Th cell interaction , p40 mRNA accumulation in APC was shown to be up-regulated by stimulation with ***CD40*** ***ligand*** ( ***CD40L*** ) on Th cells .	parallel	1
3302	10352257	959;958	CD40L;CD40	However , the ******CD40-CD40L****** ***interaction*** scarcely induced p35 mRNA accumulation in APC .	parallel	1
3303	10352257	959;3592	CD40L;p35	However , the ***CD40-CD40L*** interaction scarcely ***induced*** ***p35*** mRNA accumulation in APC .	target	1
3304	10352257	958;3592	CD40;p35	However , the ***CD40-CD40L*** interaction scarcely ***induced*** ***p35*** mRNA accumulation in APC .	target	1
3305	10352267	973;974	Ig alpha;Ig beta	Furthermore , ******Ig alpha/Ig beta****** ***complexes*** in which the immunoreceptor tyrosine-based activation motif tyrosines of Ig alpha were mutated were also incapable of accessing the MIIC or of facilitating the presentation of Ag .	parallel	1
3306	10352279	940;3558	CD28;IL-2	***CD28*** costimulation ***augments*** ***IL-2*** secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation .	positive	0
3307	10352284	4261;942	CIITA;CD86	These data suggest that if ***CIITA*** and ***CD86*** ***cooperate*** , enhanced tumor immunity could be achieved .	parallel	0
3308	10352287	959;958	CD40 ligand;CD40	******CD40-CD40 ligand****** ***interaction*** is central to cell-mediated immunity against Toxoplasma gondii : patients with hyper IgM syndrome have a defective type 1 immune response that can be restored by soluble CD40 ligand trimer .	parallel	1
3309	10352287	958;959	CD40;CD40L	We demonstrate that ******CD40-CD40L****** ***interaction*** in humans is critical for generation of the IL-12 / IFN-gamma immune response against Toxoplasma gondii .	parallel	1
3310	10352287	958;959	CD40;CD40L	******CD40-CD40L****** ***signaling*** was required for optimal T cell production of IFN-gamma in response to T. gondii .	parallel	0
3311	10352287	959;958	CD40L;CD40	Not only was IL-12 production in response to T. gondii dependent on ******CD40-CD40L****** ***signaling*** , but also , patients with HIGM syndrome exhibited deficient in vitro secretion of this cytokine in response to the parasite .	parallel	0
3312	10352303	958;7124	CD40;TNF-alpha	By also measuring TNF-alpha levels , specificity of cytokine regulation was observed ; while ***anti-CD40*** and CTLA-4-Fc ***reduced*** IL-10 and ***TNF-alpha*** levels , anti-CD23 did not affect TNF-alpha while attenuating IL-10 generation .	negative	1
3313	10352342	7157;578	p53;BAK	Thus , wild-type ***p53*** ***induces*** ***BAK*** and CD95 expression in human glioma cells without enhancing their susceptibility to CD95-mediated apoptosis , and mutant p53 modulates CD95L-evoked apoptotic signalling in a gain-of-function fashion up-stream and down-stream of caspase 3 activation .	target	1
3314	10352342	7157;355	p53;CD95	Thus , wild-type ***p53*** ***induces*** BAK and ***CD95*** expression in human glioma cells without enhancing their susceptibility to CD95-mediated apoptosis , and mutant p53 modulates CD95L-evoked apoptotic signalling in a gain-of-function fashion up-stream and down-stream of caspase 3 activation .	target	1
3315	10352342	7157;578	p53;BAK	***p53*** ***enhances*** ***BAK*** and CD95 expression in human malignant glioma cells but does not enhance CD95L-induced apoptosis .	positive	0
3316	10352342	7157;355	p53;CD95	***p53*** ***enhances*** BAK and ***CD95*** expression in human malignant glioma cells but does not enhance CD95L-induced apoptosis .	positive	0
3317	10352342	356;355	CD95L;CD95	The temperature-sensitive murine p53val135 mutant was introduced into 3 human malignant glioma cell lines to examine the effects of the p53 status on BCL-2 family protein expression , CD95 expression , and sensitivity to ***CD95*** ***ligand*** ( ***CD95L*** ) - induced apoptosis .	parallel	1
3318	10352357	3553;7124	IL-1beta;TNFalpha	The addition of ***IL-1beta*** resulted in an increase in the release of IL-6 and MCP-1 , similar to that observed with LPS stimulation , but failed to ***increase*** the production of ***TNFalpha*** .	positive	0
3319	10352357	3553;6348	IL-1beta;MIP-1alpha	***MIP-1alpha*** production was only marginally ***enhanced*** by ***IL-1beta*** .	positive	0
3320	10353405	2208;3565	CD23;IL-4	The upregulation of ***CD23*** ***correlates*** with greater ***IL-4*** activity in the culture supernatant of MCNS peripheral blood lymphocytes ( PBLs ) than normal PBLs stimulated by mitogens , as assessed by the CD23-inducing effect of the PBL supernatant on tonsillar B cells .	parallel	0
3321	10353468	3596;7412	IL-13;VCAM-1	In this study we found IL-4 to induce both intercellular cell adhesion molecule-1 ( ICAM-1 ) and VCAM-1 expression , whereas ***IL-13*** ***induced*** ***VCAM-1*** only .	target	1
3322	10353474	308;5321	Annexin V;cPLA2	We report that ***Annexin V*** ***modulates*** the activity of cPKCs as well as of ***cPLA2*** by interfering with their ability to bind to negatively charged phospholipids and calcium .	target	0
3323	10353605	2885;6464	Grb2;Shc	We also found that ShcdeltaCH1 could associate with p185 * ; however , this association did not interfere with the endogenous Shc-p185 * interaction or the ******Shc-Grb2****** ***interaction*** .	parallel	1
3324	10353694	1437;2822	GM-CSF;PLD	Taken together the data indicate that ***GM-CSF*** rapidly ***activates*** ***PLD*** in adherent cells , which is responsible for the generation of PA .	positive	1
3325	10353695	6776;3960	Stat5a;Gal4	A fusion protein ( Gal4-Stat5 ( 695 ) ) , containing the C-terminal domain of ***Stat5a*** ( amino acids 695-794 ) ***linked*** to the DNA-binding domain of ***Gal4*** ( Gal4 DBD ) , strongly activated transcription of a luciferase reporter gene .	parallel	0
3326	10353724	811;5551	Calreticulin;perforin	These observations open the possibilities that membrane-bound ***Calreticulin*** ***prevents*** hydrophobic entry of ***perforin*** into membranes and ( or ) prevents perforin from assembling into polyperforin pores .	negative	0
3327	10353724	811;5551	Calreticulin;perforin	The calcium-independent ***association*** of ***perforin*** and ***Calreticulin*** prompted our evaluation of Calreticulin 's potential to function as a regulatory molecule that protects cytotoxic lymphocytes from their own perforin .	parallel	0
3328	10353724	5551;811	perforin;Calreticulin	Previously , we found that millimolar levels of calcium in the hemolytic assays dissociate high-affinity perforin-Calreticulin complexes , which makes it unlikely that ***perforin*** ***associates*** with ***Calreticulin*** in solution when hemolysis is blocked .	parallel	0
3329	10353724	811;5551	Calreticulin;perforin	Previously , we found that millimolar levels of calcium in the hemolytic assays dissociate high-affinity ******perforin-Calreticulin****** ***complexes*** , which makes it unlikely that perforin associates with Calreticulin in solution when hemolysis is blocked .	parallel	1
3330	10353724	811;5551	Calreticulin;perforin	***Calreticulin*** may ***affect*** ***perforin*** at the erythrocyte membrane .	target	0
3331	10353729	1029;1019	p16;Cdk4	The ***p16*** protein ***associates*** exclusively with ***Cdk4*** and Cdk6 , inhibiting their complexation with D-type cyclins and the consequent phosphorylation of pRb .	parallel	0
3332	10353729	1029;1021	p16;Cdk6	The ***p16*** protein ***associates*** exclusively with Cdk4 and ***Cdk6*** , inhibiting their complexation with D-type cyclins and the consequent phosphorylation of pRb .	parallel	0
3333	10353845	1475;1508	cystatin A;cathepsin B	In contrast , the N-terminal region is required also for an initial ***binding*** of ***cystatin A*** to ***cathepsin B*** , presumably by promoting the displacement of the occluding loop and allowing facile interaction of the rest of the inhibiting wedge with the active-site cleft of the enzyme .	parallel	1
3334	10354271	3303;596	HSP 72;Bcl2	***HSP 72*** , a known cytoprotectant , ***co-immunoprecipitated*** with ***Bcl2*** , an anti-apoptotic protein .	parallel	1
3335	10354271	3303;596	HSP 72;Bcl2	Prior heat stress markedly increased the ***interaction*** between ***HSP 72*** and ***Bcl2*** .	parallel	1
3336	10354271	3303;596	HSP 72;Bcl2	Novel ***interactions*** between ***HSP 72*** and ***Bcl2*** may be responsible , at least in part , for the protection afforded by prior heat stress against ATP depletion injury .	parallel	1
3337	10354273	3458;941	IFN-gamma;B7-1	***IFN-gamma*** and LPS differentially ***modulate*** class II MHC and ***B7-1*** expression on murine renal tubular epithelial cells .	target	0
3338	10354352	3600;3458	IL-15;interferon gamma	Further , the CTL response to parasite infected target cells as well as the production of ***interferon gamma*** was ***enhanced*** by ***IL-15/TLA*** administration in the alpha - / - mice .	positive	0
3339	10354362	1508;3818	cysteine protease;plasma prekallikrein	On endothelial cells , ***plasma prekallikrein*** is ***activated*** by a membrane-associated ***cysteine protease*** .	positive	1
3340	10354373	6737;973	Ro52;IgA	***Ro52*** ***interacted*** with IgG1 and IgG4 , but not with IgG2 , IgG3 , ***IgA*** or IgM .	parallel	1
3341	10354373	6737;3502	Ro52;IgG3	***Ro52*** ***interacted*** with IgG1 and IgG4 , but not with IgG2 , ***IgG3*** , IgA or IgM .	parallel	1
3342	10354379	3439;4599	IFN-alpha;MxA	The ***IFN-alpha*** produced by cells of patients infected with HIV-1 was able to ***induce*** ***MxA*** protein in human amnions WISH cells but was unable to protect these cells against Vesicular Stomatitis Virus ( VSV ) - induced cytopathic effects .	target	1
3343	10354480	5015;5949	OTX2;IRBP	Here we demonstrate that the human homeodomain protein ***OTX2*** is present in nuclear extracts of IRBP expressing cells and specifically ***interacts*** with the ***IRBP*** A promoter element in vitro .	parallel	1
3344	10354480	1406;5949	CRX;IRBP	OTX2 , as well as ***CRX*** , a homeodomain protein very similar to OTX2 , ***activates*** the human ***IRBP*** promoter in co-transfection experiments .	positive	1
3345	10354480	5015;5949	OTX2;IRBP	***OTX2*** , as well as CRX , a homeodomain protein very similar to OTX2 , ***activates*** the human ***IRBP*** promoter in co-transfection experiments .	positive	1
3346	10354513	3667;3643	IRS-1;insulin receptor	In this model , we have shown that : ( 1 ) lipids were incorporated in treated HepG2 cells , but redistributed differently when compared to treated ZHC cells ; ( 2 ) that insulin signaling events , such as insulin receptor autophosphorylation and the phosphorylation of the major ***insulin receptor*** ***substrate*** ( ***IRS-1*** ) were altered in response to the addition of membrane lipids or cholesterol derived components ; and ( 3 ) different lipids affected insulin receptor signaling differently .	parallel	1
3347	10355595	7124;836	TNF-alpha;caspase-3	DbcAMP also inhibited the ***TNF-alpha/cycloheximide-induced*** ***activation*** of ***caspase-3*** , but it had no effect on the activation of caspase-8 in human neutrophils .	positive	1
3348	10355597	133;1432	adrenomedullin;P38	These results indicate that : ( a ) In rat mesangial cells adrenomedullin-mediated inhibition of [ 3H ] thymidine incorporation and stimulation of nucleosome-associated cytoplasmic DNA fragmentation are sensitive to SB203580 , and ( b ) ***adrenomedullin*** ***activates*** a ***P38*** MAPK through a wortmannin-sensitive kinase .	positive	1
3349	10355597	133;820	adrenomedullin;cAMP	In cultured rat glomerular mesangial cells ***adrenomedullin*** ***increases*** ***cAMP*** , decreases proliferation and increases apoptosis .	positive	0
3350	10355629	1605;1756	beta-dystroglycan;dystrophin	Targeted mutagenesis of conserved WW domain residues reveals that the ******dystrophin/beta-dystroglycan****** ***interaction*** occurs primarily through the WW domain of dystrophin .	parallel	1
3351	10355633	3553;351	IL-1beta;PN-II	Neither serum depletion - nor ***IL-1beta-induced*** ***stimulation*** of extracellular ***PN-II*** accumulation were accompanied by obvious alteration of the levels of APP mRNA and cellular APP holoprotein , suggesting that the enhanced extracellular accumulation of PN-II might result from up-regulation of the secretory pathway of APP .	positive	0
3352	10355820	83992;7124	ORF4;TNF-alpha	End-phosphorothioated ***ORF4*** ( ORF4-PE ) significantly ***reduced*** ***TNF-alpha*** mRNA levels by greater than 80 % ( p < 0.001 ) and protein levels by 60 % ( p < 0.001 ) in U937 cells .	negative	1
3353	10355820	83992;7124	ORF4;TNF-alpha	***ORF4-PE*** ***reduced*** newly synthesized ***TNF-alpha*** protein levels by > 80 % in lipopolysaccharide ( LPS ) - stimulated human macrophages , by greater than 60 % in phorbol myristate acetate/phyto-hemagglutinin ( PMA/PHA ) - stimulated human peripheral blood mononuclear cells ( PBMC ) , and by approximately 50 % in LPS-stimulated murine monocytes .	negative	1
3354	10355881	796;796	CGRP;calcitonin	Quantitative receptor autoradiography was used to evaluate potential alterations in substance P ( SP ) and ***calcitonin*** gene-related peptide ( ***CGRP*** ) ***binding*** in the L4 spinal segment of rats following unilateral poisoning of the sciatic nerve with pronase .	parallel	1
3355	10356288	847;5595	catalase;ERK1	Addition of extracellular ***catalase*** during ZAS stimulation significantly ***reduced*** the tyrosine phosphorylation response and the activation of ***ERK1*** and ERK2 and their activator MEK1/2 while it did not affect that of p38 MAPK and MKK3/MKK6 .	negative	1
3356	10356288	847;5594	catalase;ERK2	Addition of extracellular ***catalase*** during ZAS stimulation significantly ***reduced*** the tyrosine phosphorylation response and the activation of ERK1 and ***ERK2*** and their activator MEK1/2 while it did not affect that of p38 MAPK and MKK3/MKK6 .	negative	1
3357	10356288	847;5605	catalase;MEK1/2	Addition of extracellular ***catalase*** during ZAS stimulation significantly ***reduced*** the tyrosine phosphorylation response and the activation of ERK1 and ERK2 and their activator ***MEK1/2*** while it did not affect that of p38 MAPK and MKK3/MKK6 .	negative	1
3358	10356295	4902;1103	neurturin;choline acetyltransferase	Here , we report that ***neurturin*** , like GDNF , ***increases*** the ***choline acetyltransferase*** activity of normal postnatal motor neurons , induces neurite outgrowth in spinal cord , and potently protects motor neurons from chronic glutamate-mediated degeneration .	positive	0
3359	10356298	1000;5594	N-cadherin;ERK	We have found that ***N-cadherin*** , as well as laminin ( LN ) and basic fibroblast growth factor ( bFGF ) , can ***activate*** ***ERK*** in embryonic chick retinal neurons .	positive	1
3360	10356298	1000;5594	N-cadherin;ERK	We conclude ( 1 ) that ***N-cadherin*** and LN can ***activate*** ***ERK*** in retinal neurons and ( 2 ) that activation of ERK is required for full neurite outgrowth induced by these proteins .	positive	1
3361	10356322	4790;3659	NF-kappaB;IRF-1	We conclude that ***IRF-1*** and ***NF-kappaB*** ***interact*** in vivo , and that this interaction physically bends the indicible nitric oxide synthase promoter DNA .	parallel	1
3362	10356322	4790;3659	NF-kappaB;IRF-1	Co-immunoprecipitation experiments show that ***IRF-1*** and ***NF-kappaB*** ***interact*** in stimulated but not resting cells .	parallel	1
3363	10356322	4790;3659	NF-kappaB;IRF-1	Super-shift experiments show that ***IRF-1*** and ***NF-kappaB*** ***interact*** while binding to their respective DNA binding sites .	parallel	1
3364	10356322	4790;3659	NF-kappaB;IRF-1	These results demonstrate the existence of a physical ***interaction*** between ***IRF-1*** and ***NF-kappaB*** proteins in vivo .	parallel	1
3365	10356322	4790;3659	NF-kappaB;IRF-1	We next suggested that this ***interaction*** between ***IRF-1*** and ***NF-kappaB*** bends the DNA of the iNOS promoter region .	parallel	1
3366	10356357	1437;6776	GM-CSF;STAT5	***Activation*** of a functionally distinct 80-kDa ***STAT5*** isoform by IL-5 and ***GM-CSF*** in human eosinophils and neutrophils .	positive	1
3367	10356357	3567;6776	IL-5;STAT5	***Activation*** of a functionally distinct 80-kDa ***STAT5*** isoform by ***IL-5*** and GM-CSF in human eosinophils and neutrophils .	positive	1
3368	10356357	1437;6776	GM-CSF;STAT5	We show that different ***STAT5*** isoforms are ***activated*** by IL-5 and ***GM-CSF*** in eosinophils , neutrophils , and differentiated eosinophilic HL-60 cells .	positive	1
3369	10356357	3567;6776	IL-5;STAT5	We show that different ***STAT5*** isoforms are ***activated*** by ***IL-5*** and GM-CSF in eosinophils , neutrophils , and differentiated eosinophilic HL-60 cells .	positive	1
3370	10356357	3567;6776	IL-5;STAT5A	Whereas ***IL-5*** ***activated*** the wild-type ***STAT5A*** and STAT5B proteins in HL60-eos cells , a carboxyl-terminally truncated 80-kDa STAT5 isoform was activated in mature eosinophils and neutrophils .	positive	1
3371	10356357	3567;6777	IL-5;STAT5B	Whereas ***IL-5*** ***activated*** the wild-type STAT5A and ***STAT5B*** proteins in HL60-eos cells , a carboxyl-terminally truncated 80-kDa STAT5 isoform was activated in mature eosinophils and neutrophils .	positive	1
3372	10356358	3192;3643	pp120;insulin receptor	Cell adhesion properties and effects on receptor-mediated insulin endocytosis are independent properties of ***pp120*** , a ***substrate*** of the ***insulin receptor*** tyrosine kinase .	parallel	1
3373	10356359	5008;5594	oncostatin M;MAPK2	***Activation*** of Jak-Stat and ***MAPK2*** pathways by ***oncostatin M*** leads to growth inhibition of human glioma cells .	positive	1
3374	10356360	650;4684	bone morphogenetic protein-2;NCAM	Homeobox proteins as signal transduction intermediates in ***regulation*** of ***NCAM*** expression by recombinant human ***bone morphogenetic protein-2*** in osteoblast-like cells .	target	1
3375	10356361	5371;1026	PML;p21	Transcriptional ***activation*** of the cyclin-dependent kinase inhibitor ***p21*** by ***PML/RARalpha*** .	positive	1
3376	10356361	5914;1026	RARalpha;p21	Transcriptional ***activation*** of the cyclin-dependent kinase inhibitor ***p21*** by ***PML/RARalpha*** .	positive	1
3377	10356364	1435;6774	CSF-1;STAT3	***CSF-1-mediated*** ***activation*** of ***STAT3*** was also abrogated in the M1/Y559F cell line .	positive	1
3378	10356400	8878;8737	p62;RIP	The ***interaction*** of ***p62*** with ***RIP*** links the atypical PKCs to NF-kappaB activation .	parallel	1
3379	10356400	3551;4790	IKKbeta;NF-kappaB	The two members of the atypical protein kinase C ( aPKC ) subfamily of isozymes ( zetaPKC and lambda/iotaPKC ) are involved in the ***control*** of nuclear factor kappaB ( ***NF-kappaB*** ) through ***IKKbeta*** activation .	target	0
3380	10356400	8878;8737	p62;RIP	Here we show that the previously described aPKC-binding protein , ***p62*** , selectively ***interacts*** with ***RIP*** but not with TRAF2 in vitro and in vivo .	parallel	1
3381	10356400	7124;4790	TNFalpha;NF-kappaB	Together , these results demonstrate that the interaction of p62 with RIP serves to link the atypical PKCs to the ***activation*** of ***NF-kappaB*** by the ***TNFalpha*** signaling pathway .	positive	1
3382	10356400	8878;8737	p62;RIP	Together , these results demonstrate that the ***interaction*** of ***p62*** with ***RIP*** serves to link the atypical PKCs to the activation of NF-kappaB by the TNFalpha signaling pathway .	parallel	1
3383	10357258	1392;5443	CRF;adrenocorticotropin	***CRF*** ***increased*** ***adrenocorticotropin*** ( ACTH ) secretion from AtT-20 cells , and CRA1000 and CRA1001 inhibited CRF-induced ACTH secretion , concentration-dependently , as did other CRF1 receptor antagonists .	positive	0
3384	10357466	6387;1234	SDF-1;CCR5	All group O isolates tested were efficiently inhibited by ***SDF-1*** or RANTES , the natural ***ligands*** of CXCR4 and ***CCR5*** , respectively .	parallel	1
3385	10357466	6387;7852	SDF-1;CXCR4	All group O isolates tested were efficiently inhibited by ***SDF-1*** or RANTES , the natural ***ligands*** of ***CXCR4*** and CCR5 , respectively .	parallel	1
3386	103576	12;1511	alpha-1-antichymotrypsin;cathepsin G	***Complexes*** of ***alpha-1-antichymotrypsin*** with human chymotrypsin and human leukocyte ***cathepsin G*** are stable in sodium dodecyl sulfate and have molecular weights near 90,000 suggesting 1:1 complex formation on a molar basis between inhibitor and enzyme .	parallel	1
3387	10357789	5320;324	Pla2g2a;Apc	In an attempt to determine the genetic factors implicated in the susceptibility to formation of ACFs , a possible involvement of the adenomatous polyposis gene ( ***Apc*** ) and its ***modifier*** secretory phospholipase A2 ( ***Pla2g2a*** ) was analyzed .	target	0
3388	10357807	965;914	CD58;CD2	The new structural information supports a ' hand-shake ' model of ******CD2-CD58****** ***interaction*** involving the GFCC ' C " faces of both CD2 and CD58 adhesion domains .	parallel	1
3389	10357817	1499;7157	beta-catenin;p53	Excess ***beta-catenin*** ***promotes*** accumulation of transcriptionally active ***p53*** .	positive	0
3390	10357823	2081;610	Ire1p;HAC1	In the yeast Saccharomyces cerevisiae , the bifunctional transmembrane kinase/endoribonuclease ***Ire1p*** ***cleaves*** ***HAC1*** mRNA at both splice junctions and tRNA ligase joins the two exons together .	target	1
3391	10357833	3458;4018	IFN-gamma;lipoprotein	***IFN-gamma*** ***increased*** low density ***lipoprotein*** ( LDL ) - induced cellular CE 2-fold compared to LDL alone .	positive	0
3392	10357834	3949;348	LDL receptor;apoE	***LDL receptor*** ***binds*** newly synthesized ***apoE*** in macrophages .	parallel	1
3393	10357834	348;3949	apoE;LDL receptor	The results of these studies indicated that nascent macrophage-derived ***apoE*** ***binds*** to the ***LDL receptor*** , and that this apoE served as a precursor pool for apoE released into the medium .	parallel	1
3394	10357837	6347;729230	MCP-1;CCR2	The accumulation of monocytes is mediated by the ***interaction*** of locally produced chemoattractant protein-1 ( ***MCP-1*** ) with its receptor ***CCR2*** .	parallel	1
3395	10357838	336;3990	ApoA-II;hepatic lipase	In summary , these results strongly suggest that ***ApoA-II*** is a physiological ***inhibitor*** of ***hepatic lipase*** and that this is at least part of the mechanism whereby ApoA-II maintains HDL cholesterol levels .	negative	1
3396	10357844	5360;4018	PLTP;lipoprotein	The plasma phospholipid transfer protein ( ***PLTP*** ) is an important ***regulator*** of high density ***lipoprotein*** ( HDL ) metabolism .	target	1
3397	10357875	3952;969	leptin;CD69	Moreover , ***leptin*** ***increases*** the expression of the early activation marker ***CD69*** in monocytes but not in lymphocytes .	positive	0
3398	10357879	820;5599	cAMP;JNK	***DB-cAMP*** also ***blocked*** PMA-induced ***JNK*** activation .	negative	0
3399	10357882	355;5599	Fas;JNK	We recently observed that in T lymphocytes ***Fas*** strongly ***induced*** activation of ***JNK*** ( c-Jun N-terminal kinase ) but not of second messengers leading to activation of ERK ( extracellular regulated kinase ) .	target	1
3400	10357882	5604;5594	MEK1;ERK	This was confirmed in the current study by showing that activation of ***MEK1*** , the upstream ***regulator*** of ***ERK*** , reduces Fas-mediated apoptosis , whereas inhibition of MEK1 augments apoptosis by Fas .	target	1
3401	10357921	356;355	Fas ligand;Fas	CONCLUSIONS : These results strongly suggest that ******Fas/Fas ligand****** ***interaction*** mediates the liver injury during allograft rejection .	parallel	1
3402	10358028	7421;85329	VDR;GRIP-1	Compared with the ***interaction*** of ***VDR*** with RXR or ***GRIP-1*** , the differentiation dose-response most closely correlated to the ligand-dependent recruitment of the DRIP coactivator complex to VDR and to the ability of the receptor to activate transcription in a cell-free system .	parallel	1
3403	10358032	8737;4790	RIP;NF-kappaB	Previous studies have shown that ***RIP*** ***mediates*** TNF-induced activation of the anti-apoptotic ***NF-kappaB*** pathway .	target	0
3404	10358044	328;3725	Redox factor-1;AP-1	***Redox factor-1*** ( Ref-1 ) ***mediates*** the activation of ***AP-1*** in HeLa and NIH 3T3 cells in response to heat shock .	target	0
3405	10358044	328;3725	Ref-1;AP-1	Electrophoretic mobility shift assay extracts immunodepleted of Ref-1 protein demonstrated that the increase in AP-1 DNA-binding activity following heating was dependent upon the presence of Ref-1 and that ***Ref-1*** ***regulates*** inducible , but not basal , ***AP-1*** DNA-binding activity .	target	1
3406	10358045	3815;4254	c-Kit;SCF	Stem cell factor ( ***SCF*** ) and its tyrosine kinase ***receptor*** , ***c-Kit*** , play a crucial role in regulating migration and proliferation of melanoblasts , germ cells , and hemopoietic cell progenitors by activating a number of intracellular signaling molecules .	parallel	1
3407	10358050	8178;7157	ELL;p53	Our observations indicate the existence of a mutually inhibitory interaction between p53 and a general transcription elongation factor ELL and raise the possibility that an aberrant ***interaction*** between ***p53*** and ***ELL*** may play a role in the genesis of leukemias carrying MLL-ELL gene translocations .	parallel	1
3408	10358050	7157;8178	p53;ELL	Physical ***interaction*** and functional antagonism between the RNA polymerase II elongation factor ***ELL*** and ***p53*** .	parallel	1
3409	10358050	8178;7157	ELL;p53	Thus , ***ELL*** acts as a negative ***regulator*** of ***p53*** in transcription .	negative	1
3410	10358050	7157;8178	p53;ELL	Conversely , ***p53*** ***inhibits*** the transcription elongation activity of ***ELL*** , suggesting that p53 is capable of regulating general transcription by RNA polymerase II through controlling the ELL activity .	negative	1
3411	10358050	7157;1026	p53;p21	Elevated levels of ELL in cells resulted in the inhibition of ***p53-dependent*** ***induction*** of endogenous ***p21*** and substantially protected cells from p53-mediated apoptosis that is induced by genotoxic stress .	target	1
3412	10358067	8839;632	CTGF-L;osteocalcin	In addition , recombinant human ***CTGF-L*** ***inhibits*** ***osteocalcin*** production in rat osteoblast-like Ros 17/2 .8 cells .	negative	1
3413	10358076	2308;3484	FKHR;insulin-like growth factor-binding protein-1	Reporter gene studies in HepG2 hepatoma cells show that ***FKHR*** ***stimulates*** ***insulin-like growth factor-binding protein-1*** promoter activity through an IRS , and introduction of IRSs confers this effect on a heterologous promoter .	positive	0
3414	10358076	2308;207	FKHR;PKB	Antisense studies indicate that ***FKHR*** contributes to basal promoter function and is required to ***mediate*** effects of insulin and ***PKB*** on promoter activity via an IRS .	target	0
3415	10358076	207;2308	PKB;FKHR	To our knowledge , these results provide the first report that FKHR stimulates promoter activity through an IRS and that ***phosphorylation*** of ***FKHR*** by ***PKB*** mediates effects of insulin on gene expression .	target	1
3416	10358077	3458;836	IFN-gamma;caspase-3	In addition , IFN-gamma/TNF-alpha and ***IL-1alpha/IFN-gamma/TNF-alpha*** ***stimulate*** activation of caspase-8 and ***caspase-3*** , which IL-13 pretreatment was able to partially inhibit and delay .	positive	0
3417	10358077	3458;841	IFN-gamma;caspase-8	In addition , IFN-gamma/TNF-alpha and ***IL-1alpha/IFN-gamma/TNF-alpha*** ***stimulate*** activation of ***caspase-8*** and caspase-3 , which IL-13 pretreatment was able to partially inhibit and delay .	positive	0
3418	10358077	3552;836	IL-1alpha;caspase-3	In addition , IFN-gamma/TNF-alpha and ***IL-1alpha/IFN-gamma/TNF-alpha*** ***stimulate*** activation of caspase-8 and ***caspase-3*** , which IL-13 pretreatment was able to partially inhibit and delay .	positive	0
3419	10358077	3552;841	IL-1alpha;caspase-8	In addition , IFN-gamma/TNF-alpha and ***IL-1alpha/IFN-gamma/TNF-alpha*** ***stimulate*** activation of ***caspase-8*** and caspase-3 , which IL-13 pretreatment was able to partially inhibit and delay .	positive	0
3420	10358077	7124;836	TNF-alpha;caspase-3	In addition , IFN-gamma/TNF-alpha and ***IL-1alpha/IFN-gamma/TNF-alpha*** ***stimulate*** activation of caspase-8 and ***caspase-3*** , which IL-13 pretreatment was able to partially inhibit and delay .	positive	0
3421	10358077	7124;841	TNF-alpha;caspase-8	In addition , IFN-gamma/TNF-alpha and ***IL-1alpha/IFN-gamma/TNF-alpha*** ***stimulate*** activation of ***caspase-8*** and caspase-3 , which IL-13 pretreatment was able to partially inhibit and delay .	positive	0
3422	10358077	3596;2185	IL-13;protein kinase B	***IL-13*** also ***stimulates*** activation of the major PI 3-kinase effector , ***protein kinase B*** .	positive	0
3423	10358077	3596;2185	IL-13;protein kinase B	The PI 3-kinase inhibitors wortmannin and LY294002 inhibit ***IL-13*** ***stimulation*** of ***protein kinase B*** as well as the cell survival effects of IL-13 .	positive	0
3424	10358078	5321;118460	cPLA2;p11	In order to determine if increased p11 protein expression resulted in increased interaction between p11 and cPLA2 , anti-cPLA2 antibodies were used to immunoprecipitate ******p11.cPLA2****** ***complexes*** and Western blots of the immunoprecipitate were used to detect p11 .	parallel	1
3425	10358078	5321;118460	cPLA2;p11	In order to determine if increased p11 protein expression resulted in increased ***interaction*** between ***p11*** and ***cPLA2*** , anti-cPLA2 antibodies were used to immunoprecipitate p11.cPLA2 complexes and Western blots of the immunoprecipitate were used to detect p11 .	parallel	1
3426	10358079	2064;2066	ErbB2;ErbB4	However , neu differentiation factor-induced ***heterodimers*** of ***ErbB2*** and ***ErbB4*** activated Stat5 .	parallel	1
3427	10358079	2064;6777	ErbB2;Stat5	However , neu differentiation factor-induced heterodimers of ***ErbB2*** and ErbB4 ***activated*** ***Stat5*** .	positive	1
3428	10358079	2066;6777	ErbB4;Stat5	However , neu differentiation factor-induced heterodimers of ErbB2 and ***ErbB4*** ***activated*** ***Stat5*** .	positive	1
3429	10358079	6772;1956	Stat1;ErbB1	In A431 cells , ***Stat1*** , Stat3 , and Stat5 , were constitutively ***complexed*** with ***ErbB1*** and rapidly phosphorylated on tyrosine in response to EGF .	parallel	1
3430	10358079	6774;1956	Stat3;ErbB1	In A431 cells , Stat1 , ***Stat3*** , and Stat5 , were constitutively ***complexed*** with ***ErbB1*** and rapidly phosphorylated on tyrosine in response to EGF .	parallel	1
3431	10358079	6777;1956	Stat5;ErbB1	In A431 cells , Stat1 , Stat3 , and ***Stat5*** , were constitutively ***complexed*** with ***ErbB1*** and rapidly phosphorylated on tyrosine in response to EGF .	parallel	1
3432	10358079	5617;6776	prolactin;Stat5a	In contrast to ***prolactin*** , which ***induced*** only Tyr694 phosphorylation of ***Stat5a*** , EGF promoted phosphorylation on Tyr694 and additional tyrosine residue ( s ) .	target	1
3433	10358083	2626;2248	GATA-4;fgf-3	In undifferentiated F9 cells , ***GATA-4*** expression ***stimulates*** the ***fgf-3*** promoter , whereas in differentiated F9 cells already expressing GATA-4 , no further increase in promoter activity was observed .	positive	0
3434	10358088	1956;322	Mena;FE65	Although this single substitution in YAP WW1 domain is sufficient to precipitate the two protein isoforms of ***Mena*** , an in vivo ***ligand*** of ***FE65*** , we showed that an additional substitution , histidine 192 ( betaB7 ) to glycine , significantly increased the ability of YAP to mimic FE65 .	parallel	1
3435	10358091	11097;7514	NLP-1;CRM-1	We show here that ***NLP-1*** , like the previously described Rev-interacting protein hRIP/Rab and several nucleoporins , also ***interacts*** with ***CRM-1*** both in yeast and mammalian cells .	parallel	1
3436	10358095	2033;2113	p300;ets-1	Two regions of ***p300/CBP*** between amino acids ( a.a. ) 328 and 596 and a. a. 1678 and 2370 independently can ***interact*** with ***ets-1*** and ets-2 in vitro and in vivo .	parallel	1
3437	10358095	2033;2114	p300;ets-2	Two regions of ***p300/CBP*** between amino acids ( a.a. ) 328 and 596 and a. a. 1678 and 2370 independently can ***interact*** with ets-1 and ***ets-2*** in vitro and in vivo .	parallel	1
3438	10358095	2114;2033	ets-2;p300	The LXXLL sequence , reported to be important in receptor-coactivator interactions , does not appear to play a role in the ***interaction*** of ***ets-2*** with ***p300/CBP*** .	parallel	1
3439	10358137	3821;3824	NKG2A;CD94	Taken together , these results suggest that the ******CD94/NKG2A****** receptor ***complex*** is the major known inhibitory receptor for class I ( Qa1b ) molecules on developing fetal NK cells .	parallel	1
3440	10358138	3824;4068	NK cell receptor;SAP	Cutting edge : human 2B4 , an activating ***NK cell receptor*** , ***recruits*** the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein ***SAP*** .	target	0
3441	10358138	3824;5781	NK cell receptor;SHP-2	Cutting edge : human 2B4 , an activating ***NK cell receptor*** , ***recruits*** the protein tyrosine phosphatase ***SHP-2*** and the adaptor signaling protein SAP .	target	0
3442	10358144	959;3458	CD40L;IFN-gamma	The expression of ***CD40L*** inversely ***correlates*** with the secretion of ***IFN-gamma*** after target cell contact ( p = 0.0001 ) , but correlations of CD40L expression and failure to secrete IFN-gamma with EC-selective killing did not reach statistical significance .	negative	0
3443	10358149	3574;3565	IL-7;IL-4	***IL-7*** ***up-regulates*** ***IL-4*** production by splenic NK1 .1 + and NK1 .1 - MHC class I-like/CD1-dependent CD4 + T cells .	positive	1
3444	10358150	3458;5696	IFN-gamma;LMP7	Consistent with these observations we show that ***up-regulation*** of ***LMP7*** by ***IFN-gamma*** enhances presentation of the VIYQYMDDL epitope .	positive	1
3445	10358152	4067;930	Lyn;CD19	Subsequently , Src-family PTKs , particularly ***Lyn*** , are proposed to ***phosphorylate*** and bind ***CD19*** , a cell-surface costimulatory molecule that regulates mature B cell activation .	target	1
3446	10358152	930;4067	CD19;Lyn	In wild-type B cells , ***CD19*** was constitutively ***complexed*** with Vav , ***Lyn*** , and other Src-family PTKs , with CD19 phosphorylation and its associations with Lyn and Vav increased after BCR ligation .	parallel	1
3447	10358152	930;4067	CD19;Lyn	Constitutive ******CD19/Lyn/Vav****** complex ***signaling*** may therefore be responsible for the establishment of baseline signaling thresholds in B cells before Ag receptor ligation , in addition to accelerating signaling following BCR engagement or other transmembrane signals .	parallel	0
3448	10358152	930;4067	CD19;Lyn	Thus , constitutive and induced ******CD19/Lyn****** ***complexes*** are likely to regulate basal signaling thresholds and BCR signaling by amplifying the kinase activity of Lyn and other Src-family PTKs .	parallel	1
3449	10358153	867;1399	Cbl;CrkL	A specific protein kinase C ( PKC ) inhibitor ( GF-109203X ) reversed the effect of PMA on tyrosine phosphorylation of Cbl and restored the activation-dependent ***association*** of ***Cbl*** with PI3-K and ***CrkL*** .	parallel	0
3450	10358153	5578;867	PKCalpha;Cbl	We also provide evidence that ***PKCalpha*** and PKCtheta can physically ***associate*** with ***Cbl*** and are able to phosphorylate it in vitro and in vivo .	parallel	0
3451	10358155	940;1432	CD28;p38 alpha	In both Th1 and Th2 cells , ***CD28*** signaling ***activated*** ***p38 alpha*** and was required for cytokine production .	positive	1
3452	10358155	940;1432	CD28;p38 alpha	Using purified human CD4 + peripheral blood T cells , we show that ***CD28*** stimulation alone ***activates*** p38 alpha mitogen-activated protein kinase ( ***p38 alpha*** ) .	positive	1
3453	10358157	3700;7852	gp120;chemokine receptor 4	Inhibition of tyrosine kinase activation blocks the ***down-regulation*** of CXC ***chemokine receptor 4*** by HIV-1 ***gp120*** in CD4 + T cells .	negative	1
3454	10358158	7535;27040	ZAP-70;LAT	These findings provide evidence that c-Cbl is involved in the negative ***regulation*** of the phosphorylation of ***LAT*** and SLP-76 by ***ZAP-70*** .	negative	1
3455	10358158	7535;3937	ZAP-70;SLP-76	These findings provide evidence that c-Cbl is involved in the negative ***regulation*** of the phosphorylation of LAT and ***SLP-76*** by ***ZAP-70*** .	negative	1
3456	10358158	867;27040	c-Cbl;LAT	These findings provide evidence that ***c-Cbl*** is involved in the negative ***regulation*** of the phosphorylation of ***LAT*** and SLP-76 by ZAP-70 .	negative	1
3457	10358158	867;3937	c-Cbl;SLP-76	These findings provide evidence that ***c-Cbl*** is involved in the negative ***regulation*** of the phosphorylation of LAT and ***SLP-76*** by ZAP-70 .	negative	1
3458	10358159	356;355	FasL;Fas	In summary , our data suggest the important regulatory role of cytokine-controlled ******Fas/FasL****** ***interaction*** in the cross-talk between keratinocytes and skin-infiltrating T cells for maintenance of homeostasis in inflammatory skin processes .	parallel	1
3459	10358159	356;355	Fas ligand;Fas	Crosstalk between keratinocytes and T lymphocytes via ******Fas/Fas ligand****** ***interaction*** : modulation by cytokines .	parallel	1
3460	10358159	356;355	FasL;Fas	Apoptosis mediated by ******Fas/FasL****** ***interaction*** plays an important role during many inflammatory skin disorders .	parallel	1
3461	10358159	3586;356	IL-10;FasL	Stimulation of the cells with IL-6 , IL-10 , IL-12 , TGF-beta1 , and GM-CSF did not modulate the constitutive FasL expression , but IFN-gamma-mediated ***FasL*** up-regulation was significantly ***diminished*** by ***IL-10*** and TGF-beta1 , respectively .	negative	0
3462	10358159	7040;356	TGF-beta1;FasL	Stimulation of the cells with IL-6 , IL-10 , IL-12 , TGF-beta1 , and GM-CSF did not modulate the constitutive FasL expression , but IFN-gamma-mediated ***FasL*** up-regulation was significantly ***diminished*** by IL-10 and ***TGF-beta1*** , respectively .	negative	0
3463	10358163	973;974	Igalpha;Igbeta	The BCR enters the class II-containing compartment as an intact ******mIg/Igalpha/Igbeta****** ***complex*** bound to Ag .	parallel	1
3464	10358164	3821;3824	NKG2-A;CD94	******CD94/NKG2-A****** inhibitory ***complex*** blocks CD16-triggered Syk and extracellular regulated kinase activation , leading to cytotoxic function of human NK cells .	parallel	1
3465	10358164	3821;3824	NKG2-A;CD94	The ******CD94/NKG2-A****** ***complex*** is the inhibitory receptor for the nonclassical MHC class I molecule HLA-E on human NK cells .	parallel	1
3466	10358164	3821;3824	NKG2-A;CD94	Both tyrosine phosphorylation and activation of Syk kinase together with tyrosine phosphorylation of CD16 receptor zeta subunit are markedly inhibited by the coengagement of ******CD94/NKG2-A****** ***complex*** .	parallel	1
3467	10358164	6464;2885	Shc;Grb-2	The block of ERK activation is exerted at an early , PTK-dependent stage in the events leading to p21ras activation , as the CD16-induced tyrosine phosphorylation of Shc adaptor protein and the formation of ******Shc/Grb-2****** ***complex*** are abrogated by CD94/NKG2-A simultaneous engagement .	parallel	1
3468	10358169	2534;10657	Fyn;Sam68	***Fyn*** membrane localization is necessary to ***induce*** the constitutive tyrosine phosphorylation of ***Sam68*** in the nucleus of T lymphocytes .	target	1
3469	10358173	3558;3659	IL-2;IRF-1	Furthermore , ***IL-2*** and IL-12 synergistically ***induced*** ***IRF-1*** , whereas IFN-alpha and IL-12 did not .	target	1
3470	10358173	6775;3659	STAT4;IRF-1	First , STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct , and second , ***STAT4*** ***binding*** to the ***IRF-1*** promoter was shown using EMSA .	parallel	1
3471	10358186	356;355	CD95L;APO-1	Induction of antitumor immunity with ***Fas/APO-1*** ***ligand*** ( ***CD95L*** ) - transfected neuroblastoma neuro-2a cells .	parallel	1
3472	10358186	356;355	FasL;Fas	Fas/APO-1 ( CD95 ) - ***Fas*** ***ligand*** ( ***FasL*** ) system has been implicated in the suppression and stimulation of immune responses .	parallel	1
3473	10358194	728;719	C5aR;C3aR	***C3aR*** internalization is a rapid negative control mechanism and is ***influenced*** by the ***C5aR*** pathway .	target	0
3474	10358194	719;718	C3aR;C3a	The ***C3a*** ***receptor*** ( ***C3aR*** ) is expressed on most human peripheral blood leukocytes with the exception of resting lymphocytes , implying a much higher pathophysiological relevance of the anaphylatoxin C3a as a proinflammatory mediator than previously thought .	parallel	1
3475	10358195	3458;3394	IFN-gamma;ICSBP	Like induction of leishmaniacidal activity , LPS and ***IFN-gamma*** synergize to ***induce*** ***ICSBP*** mRNA and protein .	target	1
3476	10358195	3458;3394	IFN-gamma;ICSBP	These findings extend in a significant way our understanding of the ***regulation*** of ***ICSBP*** by LPS and ***IFN-gamma*** and provide important clues as to its role in macrophage activation .	target	1
3477	10358200	3929;929	LBP;CD14	Class 1 mAbs blocked the binding of LPS to LBP ; class 2 mAbs blocked the ***binding*** of ***LPS/LBP*** complexes to ***CD14*** ; class 3 mAbs bound LBP but did not suppress LBP activity .	parallel	1
3478	10358200	3929;929	LBP;CD14	These results show that the neutralization of LBP accomplished by blocking either the binding of LPS to LBP or the ***binding*** of ***LPS/LBP*** complexes to ***CD14*** protects the host from LPS-induced toxicity , confirming that LBP is a critical component of innate immunity .	parallel	1
3479	10358206	3558;7852	IL-2;CXCR4	Progesterone treatment had no effect on constitutive expression of CCR5 and CXCR4 by nonactivated T cells and macrophages , but significantly inhibited ***IL-2-induced*** ***up-regulation*** of CCR5 and ***CXCR4*** on activated T cells ( p < 0.05 ) .	positive	1
3480	10358762	4049;7132	LT-alpha;CD120a	Four members of the tumor necrosis factor ( TNF ) ligand family , TNF-alpha , ***LT-alpha*** , LT-beta , and LIGHT , ***interact*** with four receptors of the TNF/nerve growth factor family , the p55 TNF receptor ( ***CD120a*** ) , the p75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions .	parallel	1
3481	10358762	4049;8764	LT-alpha;HVEM	Four members of the tumor necrosis factor ( TNF ) ligand family , TNF-alpha , ***LT-alpha*** , LT-beta , and LIGHT , ***interact*** with four receptors of the TNF/nerve growth factor family , the p55 TNF receptor ( CD120a ) , the p75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( ***HVEM*** ) to control a wide range of innate and adaptive immune response functions .	parallel	1
3482	10358762	4049;4055	LT-alpha;LT beta R	Four members of the tumor necrosis factor ( TNF ) ligand family , TNF-alpha , ***LT-alpha*** , LT-beta , and LIGHT , ***interact*** with four receptors of the TNF/nerve growth factor family , the p55 TNF receptor ( CD120a ) , the p75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( ***LT beta R*** ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions .	parallel	1
3483	10358762	7124;7132	TNF-alpha;CD120a	Four members of the tumor necrosis factor ( TNF ) ligand family , ***TNF-alpha*** , LT-alpha , LT-beta , and LIGHT , ***interact*** with four receptors of the TNF/nerve growth factor family , the p55 TNF receptor ( ***CD120a*** ) , the p75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions .	parallel	1
3484	10358762	7124;8764	TNF-alpha;HVEM	Four members of the tumor necrosis factor ( TNF ) ligand family , ***TNF-alpha*** , LT-alpha , LT-beta , and LIGHT , ***interact*** with four receptors of the TNF/nerve growth factor family , the p55 TNF receptor ( CD120a ) , the p75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( ***HVEM*** ) to control a wide range of innate and adaptive immune response functions .	parallel	1
3485	10358762	7124;4055	TNF-alpha;LT beta R	Four members of the tumor necrosis factor ( TNF ) ligand family , ***TNF-alpha*** , LT-alpha , LT-beta , and LIGHT , ***interact*** with four receptors of the TNF/nerve growth factor family , the p55 TNF receptor ( CD120a ) , the p75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( ***LT beta R*** ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions .	parallel	1
3486	10359010	4790;4609	NF-kappaB;c-Myc	Thus , ***NF-kappaB*** ***cooperates*** with ***c-Myc*** in promoting murine hepatocyte survival in a manner independent of p53 tumor suppressor activity .	parallel	0
3487	10359014	3725;2355	c-Jun;Fra-2	Here , we report that the transcriptional activity of ******Fra-2/c-Jun****** ***heterodimer*** was greatly enhanced by cotransfecting a constitutively active mutant of MEK1 gene ( MEK-DD ) into F9 cells , indicating that Fra-2 was converted into an active transactivator after phosphorylation by MAPK .	parallel	1
3488	10359075	351;43	Abeta;AChE	Stable ******AChE-Abeta****** ***complexes*** were found to be more toxic than those formed without the enzyme , for Abeta1-40 and Abeta1-42 , but not for amyloid fibrils formed with AbetaVal18-Ala , a synthetic variant of the Abeta1-40 peptide .	parallel	1
3489	10359075	351;43	Abeta;AChE	Of all the ******AChE-Abeta****** ***complexes*** tested the one containing the Abeta1-40 peptide was the most toxic .	parallel	1
3490	10359100	5788;3577	CD45;CXCR1	***CD45*** ***modulation*** of ***CXCR1*** and CXCR2 in human polymorphonuclear leukocytes .	target	0
3491	10359100	5788;3579	CD45;CXCR2	***CD45*** ***modulation*** of CXCR1 and ***CXCR2*** in human polymorphonuclear leukocytes .	target	0
3492	10359104	3565;3456	interleukin-4;IFN-beta	Its expression could be blocked in the presence of either anti-IFN-beta or ***interleukin-4*** , which ***down-regulates*** the endogenous ***IFN-beta*** production .	negative	1
3493	10359140	1029;1019	CDKN2;Cyclin-dependent kinase 4	***Cyclin-dependent kinase 4*** ***inhibitor*** ( ***CDKN2/p16*** ) is a cell cycle regulatory protein that has been demonstrated to be inactivated by mutations , deletions or transcriptional silencing during pathogenesis of a variety of human malignancies .	negative	1
3494	10359205	940;941	CD28;B7-1	Human natural killer cells were found to express ***CD28*** , a ***receptor*** for ***B7-1*** .	parallel	1
3495	10359315	5080;6908	Pax-6;TBP	In the present study it was shown that ***Pax-6*** ***interacted*** with the ***TBP*** , the DNA-binding subunit of general transcription complex TFIID .	parallel	1
3496	10359324	3557;3383	IL-1ra;ICAM-1	***IL-1ra-induced*** ***suppression*** of ***ICAM-1*** expression was accompanied by a profound decrease in corneal leukocytic infiltration by 44.6 % at day 1 ( P < 0.003 ) , 71.8 % at day 3 ( P < 0.001 ) , 60.1 % at day 7 ( P < 0.001 ) , and 63.8 % at day 14 ( P < 0.001 ) , compared with control corneas .	negative	1
3497	10359333	356;355	FasL;Fas	The role of ***Fas*** ***ligand*** ( ***FasL*** ) molecule in HFRPE-mediated apoptosis was assessed by using a mutant Jkt cell line ( DD3 ) , which is deficient in Fas-mediated signaling .	parallel	1
3498	10359456	4790;5966	NF-kappaB;Rel	Transient expression assays with NF-kappaB/Rel binding sites linked to the chloramphenicol acetyltransferase gene suggest that the PWM-induced increase in transcription is mediated by the ******NF-kappaB/Rel****** transcription factor ***complex*** .	parallel	1
3499	10359565	387;373156	RhoA;GST	Constitutively activated ***RhoA*** , loaded with [ gamma-32P ] GTP , directly ***interacted*** with ***GST-IL-1Rcd*** in a filter-binding assay .	parallel	1
3500	10359574	2885;7132	Grb2;TNFR-I	The ******TNFR-I/Grb2****** ***interaction*** is essential for the TNF-alpha-dependent activation of c-Raf-1 kinase ; activation of c-Raf-1 kinase by TNF-alpha can be blocked by coexpression of Grb2 mutants harboring inactivating point mutations in the NH2 - or COOH-terminal SH3 domain , cell-permeable peptides that disrupt the Grb2/TNFR-I interaction or transdominant negative Ras .	parallel	1
3501	10359574	2885;7132	Grb2;TNFR-I	Functionality of the ******TNFR-I/Grb2/SOS****** / Ras ***interaction*** is a prerequisite but not sufficient for TNF-alpha-dependent activation of c-Raf-1 kinase .	parallel	1
3502	10359574	7124;6610	TNF-alpha;neutral sphingomyelinase	Inhibition of the TNFR-I/FAN ( factor associated with neutral sphingomyelinase ) interaction , which is essential for ***TNF-alpha-dependent*** ***activation*** of the ***neutral sphingomyelinase*** , either by cell-permeable peptides or by deletion of the FAN binding domain , prevents activation of c-Raf-1 kinase .	positive	1
3503	10359574	2885;7132	Grb2;TNFR-I	In conclusion , ***binding*** of the ***Grb2*** adapter protein via its COOH-terminal SH3 domain to the nontyrosine kinase receptor ***TNFR-I*** results in activation of a signaling cascade known so far to be initiated , in the case of the tyrosine kinase receptors , by binding of the SH2 domain of Grb2 to phosphotyrosine .	parallel	1
3504	10359574	7124;7132	TNF-alpha;TNFR-I	Recently , c-Raf-1 kinase was identified as an intracellular target of a signal transduction cascade initiated by ***binding*** of ***TNF-alpha*** to ***TNFR-I*** .	parallel	1
3505	10359575	2204;973	FcalphaRI;hIgA	Nevertheless , they are functionally distinct in that ***FcalphaRI*** ***binds*** human IgA ( ***hIgA*** ) but not bovine IgG2 ( bIgG2 ) , whereas bFcgamma2R binds bIgG2 but not hIgA .	parallel	1
3506	10359581	23643;7099	MD-2;TLR4	***MD-2*** is physically ***associated*** with ***TLR4*** on the cell surface and confers responsiveness to LPS .	parallel	0
3507	10359610	5883;3364	hRAD9;hHUS1	We show here that the human checkpoint control protein ***hRAD9*** physically ***associates*** with two other checkpoint control proteins , hRAD1 and ***hHUS1*** .	parallel	0
3508	10359610	5883;5810	hRAD9;hRAD1	We show here that the human checkpoint control protein ***hRAD9*** physically ***associates*** with two other checkpoint control proteins , ***hRAD1*** and hHUS1 .	parallel	0
3509	10359611	5524;7431	PP2A;Vimentin	Taken together these data show that , in mammalian fibroblasts , the intermediate filament protein ***Vimentin*** is ***dephosphorylated*** by ***PP2A*** , an event targeted by B55 .	target	1
3510	10359611	5515;7431	PP2Ac;Vimentin	Both biochemical fractionation and immunofluorescence analysis of detergent-extracted cells revealed that fractions of ***PP2Ac*** , PR65 , and B55 were tightly ***associated*** with ***Vimentin*** .	parallel	0
3511	10359616	2078;7402	ets-related;utrophin	Using this region of the utrophin promoter for DNA affinity purification , immunoblots , in vitro kinase assays , electrophoretic mobility shift assays , and in vitro expression in cultured muscle cells , we demonstrate that ***ets-related*** GA-binding protein alpha/beta transcription factors are ***activators*** of the ***utrophin*** promoter .	positive	1
3512	10359656	196;1543	aryl hydrocarbon receptor;CYP1A1	Dietary flavonols quercetin and kaempferol are ligands of the ***aryl hydrocarbon receptor*** that ***affect*** ***CYP1A1*** transcription differentially .	target	0
3513	10359657	4843;859	NOS;caveolin 3	The ***association*** of ***NOS*** II with ***caveolin 3*** might have implications for the regulation of contraction of , and/or glucose uptake by , slow-twitch muscle fibres .	parallel	0
3514	10359664	1017;4082	Cdk2;MARCKS	In contrast , ***phosphorylation*** of ***MARCKS*** by ***Cdk2*** did not significantly affect further phosphorylation by PKC .	target	1
3515	10359664	983;4082	Cdk1;MARCKS	We established that Cdk2 , Cdk4 and , to a smaller extent , ***Cdk1*** that have been immunoprecipitated from cellular extracts ***phosphorylate*** ***MARCKS*** .	target	1
3516	10359668	4311;821	neprilysin;calnexin	***Interaction*** of mammalian ***neprilysin*** with binding protein and ***calnexin*** in Schizosaccharomyces pombe .	parallel	1
3517	10359668	4311;3309	NEP;BiP	The ***interactions*** of ***NEP*** with ***BiP*** and Cnx1p were , however , more refractive to the same stresses .	parallel	1
3518	10359698	4838;5308	Nodal;Pitx2	This indicates a gene cascade relationship in the propagation of left-right information , whereby ***Nodal*** ***activates*** ***Pitx2*** on the left through a double-negative mechanism involving the repression of SnR 's repressor role on Pitx2 .	positive	1
3519	10359702	207;4790	Akt;NF-kappaB	***Induction*** of ***NF-kappaB*** by the ***Akt/PKB kinase*** .	target	1
3520	10359702	5170;4790	PKB kinase;NF-kappaB	***Induction*** of ***NF-kappaB*** by the ***Akt/PKB kinase*** .	target	1
3521	10359735	2152;7035	tissue factor;tissue factor pathway inhibitor	Heightened ***tissue factor*** ***associated*** with ***tissue factor pathway inhibitor*** and prognosis in patients with unstable angina .	parallel	0
3522	10359792	4084;4149	Mad;Max	A specific histone deacetylase , Rpd3 , interacts with a variety of sequence-specific transcriptional repressors , including ******Mad-Max****** ***heterodimers*** and members of the nuclear receptor superfamily .	parallel	1
3523	10359806	3627;2833	IP-10;CXCR3	In the brain , the CCR5 ligand , MIP-1alpha , was strongly associated with microglia/macrophages , and the ***CXCR3*** ***ligand*** , ***IP-10*** , was expressed by astrocytes in MS lesions but not unaffected white matter of control or MS subjects .	parallel	1
3524	10359809	4067;207	Lyn;Akt	***Lyn*** ***inhibited*** ***Akt/PKB*** additively with an okadaic acid-sensitive endogenous phosphatase ( s ) .	negative	1
3525	10359809	4067;207	Lyn;Akt	Negative ***regulation*** of ***Akt/PKB*** by ***Lyn*** was not dependent on the protein phosphatases SHP-1 , SHP-2 , or SHIP .	negative	1
3526	10359817	1029;7157	P19;p53	Taken together , ***P19*** ( ARF ) could ***stabilize*** ***p53*** by inhibiting the nuclear export of Mdm2 .	positive	0
3527	10359817	1029;7157	P19;p53	***P19*** ( ARF ) ***stabilizes*** ***p53*** by blocking nucleo-cytoplasmic shuttling of Mdm2 .	positive	0
3528	10359817	4193;7157	Mdm2;p53	Whereas p16 ( INK4a ) restrains cell growth through preventing phosphorylation of the retinoblastoma protein , P19 ( ARF ) acts by attenuating ***Mdm2-mediated*** ***degradation*** of ***p53*** , thereby stabilizing p53 .	negative	1
3529	10359817	1029;4193	P19;Mdm2	We show here that coexpression of ***P19*** ( ARF ) ***blocks*** the nucleo-cytoplasmic shuttling of ***Mdm2*** .	negative	0
3530	10359821	5663;4851	presenilin-1;Notch-1	Proteolytic release and nuclear translocation of ***Notch-1*** are ***induced*** by ***presenilin-1*** and impaired by pathogenic presenilin-1 mutations .	target	1
3531	10359822	6772;9021	STAT-1;SOCS-3	Thus , LIF-stimulated ***SOCS-3*** gene expression is at least in part ***mediated*** by STAT-3 and ***STAT-1*** .	target	0
3532	10359822	6774;9021	STAT-3;SOCS-3	Thus , LIF-stimulated ***SOCS-3*** gene expression is at least in part ***mediated*** by ***STAT-3*** and STAT-1 .	target	0
3533	10359822	9021;3976	SOCS-3;LIF	Pituitary corticotroph ***SOCS-3*** is a novel intracellular ***regulator*** of leukemia inhibitory factor ( ***LIF*** ) - mediated proopiomelanocortin gene expression and adrenocorticotropic hormone ( ACTH ) secretion , inhibiting LIF-activated Janus kinase-signal transducers and activators of transcription ( STAT ) signaling in a negative autoregulatory loop .	target	1
3534	10359822	3976;9021	LIF;SOCS-3	A STAT-1/STAT-3 binding element , located at nucleotides -72 to -64 , was essential for ***LIF*** ***stimulation*** of ***SOCS-3*** promoter activity .	positive	0
3535	10359836	3553;3952	IL-1;Leptin	***Leptin*** actions on food intake and body temperature are ***mediated*** by ***IL-1*** .	target	0
3536	10359895	5451;3567	Oct1;IL-5	CONCLUSION : We suggest that ***Oct1*** , YY1 , and octamer-like factors binding to the -90 / -79 sequence within the proximal IL-5 promoter are involved in ***suppression*** of ***IL-5*** transcription in T cells .	negative	1
3537	10359895	3567;5451	hIL-5;Oct1	We show that the BR3 sequence contains a novel negative regulatory element located at positions -90 to -79 of the ***hIL-5*** promoter , which ***binds*** ***Oct1*** , octamer-like , and YY1 nuclear factors .	parallel	1
3538	10360183	1024;3960	CDK8;GAL4	***GAL4*** is ***regulated*** by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase ***SRB10/CDK8*** .	target	1
3539	10360378	2623;7490	transcription factor GATA-1;WT1	***WT1*** transcription is ***regulated*** in erythroid and myeloid lineages by the ***transcription factor GATA-1*** .	target	1
3540	10360383	7066;4352	thrombopoietin;Mpl	The recently defined ligand for the ***Mpl*** ***receptor*** , ***thrombopoietin*** ( TPO ) , has been found to be the principal regulatory cytokine of megakaryocytopoiesis .	parallel	1
3541	10360579	998;10188	Cdc42;ACK	Structure of the small G protein ***Cdc42*** ***bound*** to the GTPase-binding domain of ***ACK*** .	parallel	1
3542	10360628	3458;811	interferon-gamma;cC1qR	The results demonstrate that the expression of both ***cC1qR*** and gC1qR by bone marrow vascular endothelial cells is ***up-regulated*** by inflammatory mediators , ***interferon-gamma*** , tumor necrosis factor-alpha , and lipopolysaccharide ( Escherichia coli , 055 : B5 ) in a dose - and time-dependent manner , as detected by enzyme-linked immunosorbent assay .	positive	1
3543	10360628	3458;708	interferon-gamma;gC1qR	The results demonstrate that the expression of both cC1qR and ***gC1qR*** by bone marrow vascular endothelial cells is ***up-regulated*** by inflammatory mediators , ***interferon-gamma*** , tumor necrosis factor-alpha , and lipopolysaccharide ( Escherichia coli , 055 : B5 ) in a dose - and time-dependent manner , as detected by enzyme-linked immunosorbent assay .	positive	1
3544	10360628	7124;811	tumor necrosis factor-alpha;cC1qR	The results demonstrate that the expression of both ***cC1qR*** and gC1qR by bone marrow vascular endothelial cells is ***up-regulated*** by inflammatory mediators , interferon-gamma , ***tumor necrosis factor-alpha*** , and lipopolysaccharide ( Escherichia coli , 055 : B5 ) in a dose - and time-dependent manner , as detected by enzyme-linked immunosorbent assay .	positive	1
3545	10360628	7124;708	tumor necrosis factor-alpha;gC1qR	The results demonstrate that the expression of both cC1qR and ***gC1qR*** by bone marrow vascular endothelial cells is ***up-regulated*** by inflammatory mediators , interferon-gamma , ***tumor necrosis factor-alpha*** , and lipopolysaccharide ( Escherichia coli , 055 : B5 ) in a dose - and time-dependent manner , as detected by enzyme-linked immunosorbent assay .	positive	1
3546	10360640	3569;8731	HGF;Met	***Activation*** of ***Met*** by its ligand ***HGF*** has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro .	positive	1
3547	10360643	25;4609	v-abl;c-myc	Exogenous ALA induced the accumulation of substantial concentrations of PpIX in fibrosarcoma cells , and in immortalized fibroblasts transfected with the oncogene ***c-myc*** , IGF-1 receptor , IGF-1 and its ***receptor*** , v-fos , v-raf , v-Ki-ras , ***v-abl*** , or polyomavirus middle T antigen with G418 resistance selection .	parallel	1
3548	10360653	7157;1026	p53;p21	Ectopic expression of wild-type ***p53*** also ***induces*** ***p21*** , and facilitates boswellic acid-induced apoptosis .	target	1
3549	10360671	3569;7422	IL-6;VEGF	***IL-6*** , besides its thrombopoietic effect , also seems to ***affect*** the amount of ***VEGF*** stored in the platelets .	target	0
3550	10360671	3569;7422	interleukin-6;VEGF	Platelet number and ***interleukin-6*** ***correlate*** with ***VEGF*** but not with bFGF serum levels of advanced cancer patients .	parallel	0
3551	10360671	3569;7422	IL-6;VEGF	Serum ***IL-6*** levels ***correlated*** with platelet count ( r = 0.36 ; P < 10 ( -3 ) ) , with serum ***VEGF*** levels ( r = 0.55 ; P < 10 ( -4 ) ) and with the calculated load of VEGF per platelet ( r = 0.4 ; P = 3 x 10 ( -4 ) ) .	parallel	0
3552	10360681	3297;3308	HSF1;hsp70	Because the heat shock transcription factor ***HSF1*** ***mediates*** the heat-induced transcription of ***hsp70*** , the effect of age on HSF1 was also studied .	target	0
3553	10360790	5970;4790	Rela;Nfkb1	The gel supershift assay with Nfkb1 , Rela and/or Rel antibodies revealed that the specific molecular forms of NF-kappaB activated by radiation in the spleen were Nfkb1 homodimers and ******Nfkb1/Rela****** ***heterodimers*** .	parallel	1
3554	10360829	4804;627	p75NTR;neurotrophin	The low-affinity p75 ***neurotrophin*** ***receptor*** ( ***p75NTR*** ) , a cysteine-rich transmembrane glycoprotein , is frequently expressed in advanced stages of human melanoma , but the biological consequences of this expression are unknown .	parallel	1
3555	10360829	10457;627	transmembrane glycoprotein;neurotrophin	The low-affinity p75 ***neurotrophin*** ***receptor*** ( p75NTR ) , a cysteine-rich ***transmembrane glycoprotein*** , is frequently expressed in advanced stages of human melanoma , but the biological consequences of this expression are unknown .	parallel	1
3556	10360829	10457;4804	transmembrane glycoprotein;p75	The low-affinity ***p75*** neurotrophin ***receptor*** ( p75NTR ) , a cysteine-rich ***transmembrane glycoprotein*** , is frequently expressed in advanced stages of human melanoma , but the biological consequences of this expression are unknown .	parallel	1
3557	10360829	627;4803	neurotrophin;NGF	We also examined these cell lines for presence of TrkA receptor , the high-affinity ***receptor*** for nerve growth factor ( ***NGF*** ) , the prototypic ***neurotrophin*** .	parallel	1
3558	10360838	10531;5173	hMP1;leumorphin	***hMP1*** ***cleaved*** a prodynorphin-derived peptide , ***leumorphin*** , N-terminal to Arg in the monobasic processing site , as evidenced by MALDI-TOF mass spectrometry .	target	1
3559	10360965	952;695	CD38;Bruton's tyrosine kinase	***CD38*** ligation on mouse B cells by CS/2 , an anti-mouse CD38 mAb , ***induces*** proliferation , IL-5 receptor alpha chain expression and tyrosine phosphorylation of ***Bruton's tyrosine kinase*** .	target	1
3560	10360975	3458;6356	IFN-gamma;eotaxin	Although the protective effect of IFN-gamma against allergic inflammation has been assumed to result from its sole regulation of the proliferation of Th2-type T lymphocytes , these results imply that ***IFN-gamma*** can also directly act on stromal cells to ***inhibit*** ***eotaxin*** production and consequently intervene in eosinophil recruitment .	negative	1
3561	10360975	3458;6356	IFN-gamma;eotaxin	Th1-derived cytokine ***IFN-gamma*** is a potent ***inhibitor*** of ***eotaxin*** synthesis in vitro .	negative	1
3562	10360975	3565;6356	IL-4;eotaxin	Inasmuch as Th2-derived cytokine ***IL-4*** has been shown to ***stimulate*** ***eotaxin*** generation , we investigated here the effect of Th1-derived cytokine IFN-gamma on human eotaxin production .	positive	0
3563	10360983	4790;5970	p50;p65	Construction , expression , purification and functional analysis of recombinant NFkappaB ******p50/p65****** ***heterodimer*** .	parallel	1
3564	10360983	4790;5970	p50;p65	The ******p50/p65****** ***heterodimer*** is the most abundant form of the NFkappaB dimers and plays a more elaborate role in gene regulation .	parallel	1
3565	10360983	4790;5970	p50;p65	We report two methods for the large scale expression and purification of recombinant NFkappaB ******p50/p65****** ***heterodimer*** .	parallel	1
3566	10360983	4790;5970	p50;p65	The first utilizes a bacterial double expression vector which contains two ribosomal binding sites to facilitate the coexpression of the polypeptides in the ******p50/p65****** NFkappaB ***heterodimer*** .	parallel	1
3567	10361118	7066;896	Mpl ligand;cyclin D3	***Mpl ligand*** ***enhances*** the transcription of the ***cyclin D3*** gene : a potential role for Sp1 transcription factor .	positive	0
3568	10361130	3578;4790	Interleukin-9;NF-kappaB	***Interleukin-9*** ***regulates*** ***NF-kappaB*** activity through BCL3 gene induction .	target	1
3569	10361130	602;4790	BCL3;NF-kappaB	***BCL3*** encodes a protein with close homology to IkappaB proteins and ***interacts*** with p50 ***NF-kappaB*** homodimers .	parallel	1
3570	10361130	602;958	BCL3;p50	***BCL3*** encodes a protein with close homology to IkappaB proteins and ***interacts*** with ***p50*** NF-kappaB homodimers .	parallel	1
3571	10361130	3578;602	IL-9;BCL3	***BCL3*** ***induction*** by ***IL-9*** was detected as soon as 4 hours after stimulation and appeared to be dependent on the Jak/STAT pathway .	target	1
3572	10361231	3565;3458	IL-4;IFN-gamma	***IL-4*** and IL-10 ***reduced*** the effects of ***IFN-gamma*** on monocytic cells , and both cytokines were additively antagonistic to IFN-gamma in PBMC and THP-1 cells .	negative	1
3573	10361428	185;183	AT1;angiotensin II	The gene encoding ***angiotensin II*** type 1 ***receptor*** ( ***AT1*** ) is mapped on 3q21-q25 region , and a polymorphism , A1166C , is located at 3 ' untranslated region ( UTR ) .	parallel	1
3574	10361858	213;4790	albumin;NFkappaB	Therefore , ***albumin*** ***increased*** ***NFkappaB*** and reduced IkappaB levels in PTC , and MCP-1 expression was dependent on NFkappaB activation .	positive	0
3575	10361858	213;6347	albumin;monocyte chemoattractant protein-1	***Induction*** of ***monocyte chemoattractant protein-1*** by ***albumin*** is mediated by nuclear factor kappaB in proximal tubule cells .	target	1
3576	10361858	213;4790	albumin;NFkappaB	***Activation*** of ***NFkappaB*** by delipidated bovine serum ***albumin*** ( 15 mg/ml ) was detectable within 2 h , maximal after 8 h , and maintained for at least 16 h of continuous exposure .	positive	1
3577	10362102	4790;3383	NF-kappaB;ICAM-1	Synergistic ***induction*** of ***ICAM-1*** expression by cisplatin and 5-fluorouracil in a cancer cell line via a ***NF-kappaB*** independent pathway .	target	1
3578	10362250	3439;5925	IFN-alpha;pRb	Furthermore , we found that ***IFN-alpha*** not only ***suppresses*** the phosphorylation of ***pRb*** , but also alters the phosphorylation and expression of the other pocket proteins p130 and p107 .	negative	1
3579	10362250	5715;1017	p27;Cdk2	Moreover , elevated levels of ***p27*** ***correlated*** with a dissociation of cyclin ***E/Cdk2-GeneGene*** 1 or p107 complexes to yield cyclin E/Cdk2-GeneGene 4 complexes .	parallel	0
3580	10362253	5594;3725	Erk2;AP-1	Overexpression of wild-type Erk2 in Cl 30.7 b cells that contain small amounts of Erks caused a 46.6 - or 138.1-fold increase of AP-1 activity by UVB and UVC , respectively ; introduction of a dominant negative ***Erk2*** into Cl 41 cells significantly ***blocked*** the UV-induced Erks activation as well as the ***AP-1*** activation .	negative	0
3581	10362258	4803;2033	NGF;p300	Transcriptional activity of Sp1 , Sp3 and ***p300*** was specifically ***induced*** by ***NGF*** in a Gal4-fusion assay , indicating that induction of p21 during neuronal differentiation may involve regulation of the activity of these factors by NGF .	target	1
3582	10362258	4803;6670	NGF;Sp3	Transcriptional activity of Sp1 , ***Sp3*** and p300 was specifically ***induced*** by ***NGF*** in a Gal4-fusion assay , indicating that induction of p21 during neuronal differentiation may involve regulation of the activity of these factors by NGF .	target	1
3583	10362259	1499;4316	beta-catenin;matrilysin	Inactivation of the Tcf binding site increased promoter activity and overexpression of the Tcf factor , LEF-1 , significantly downregulated matrilysin promoter activity , suggesting that ***beta-catenin*** ***transactivates*** the ***matrilysin*** promoter by virtue of its ability to abrogate Tcf-mediated repression .	positive	1
3584	10362259	1499;4316	beta-catenin;matrilysin	Because genetic ablation of matrilysin decreases tumor formation in multiple intestinal neoplasia ( Min ) mice , we propose that ***regulation*** of ***matrilysin*** production by ***beta-catenin*** accumulation is a contributing factor to intestinal tumorigenesis .	target	1
3585	10362260	1647;983	Gadd45;Cdc2	Association with Cdc2 and ***inhibition*** of ***Cdc2/Cyclin B1*** kinase activity by the p53-regulated protein ***Gadd45*** .	negative	1
3586	10362260	1647;891	Gadd45;Cyclin B1	Association with Cdc2 and ***inhibition*** of ***Cdc2/Cyclin B1*** kinase activity by the p53-regulated protein ***Gadd45*** .	negative	1
3587	10362260	983;891	Cdc2;Cyclin B1	While inhibitory phosphorylation of Cdc2 and suppression of Cyclin B1 levels are known to be involved in G2 delays after genotoxic stress , Gadd45 has now been found to directly inhibit the activity of ******Cdc2/Cyclin B1****** ***complex*** , while it had no appreciable effect on Cdk2 / Cyclin E activity even at very high levels of Gadd45 .	parallel	1
3588	10362300	3976;51083	Leukemia inhibitory factor;galanin message-associated peptide	***Leukemia inhibitory factor*** ***regulates*** ***galanin/galanin message-associated peptide*** expression in cultured mouse dorsal root ganglia ; with a note on in situ hybridization methodology .	target	1
3589	10362300	3976;51083	Leukemia inhibitory factor;galanin message-associated peptide	These results support the hypothesis that ***Leukemia inhibitory factor*** is an important ***regulator*** of ***galanin/galanin message-associated peptide*** expression following axotomy , and may therefore be involved in the defence mechanisms against neuropathic pain at the level of dorsal root ganglion neurons .	target	1
3590	10362352	10524;602	Tip60;Bcl-3	Furthermore , the histone acetylase ***Tip60*** ***enhances*** ***Bcl-3-p50*** activated transcription through an NF-kappaB binding site , indicating that quarternary complexes containing Bcl-3 interactors modulate NF-kappaB driven gene expression .	positive	0
3591	10362352	10524;4790	Tip60;p50	Furthermore , the histone acetylase ***Tip60*** ***enhances*** ***Bcl-3-p50*** activated transcription through an NF-kappaB binding site , indicating that quarternary complexes containing Bcl-3 interactors modulate NF-kappaB driven gene expression .	positive	0
3592	10362354	2185;3717	protein kinase B;JAK2	Activation of ***protein kinase B*** ( PKB ) ***required*** ***JAK2*** and was inhibited by dominant-negative phosphatidylinositol 3-kinase ( P13K ) .	target	0
3593	10362354	3717;5595	JAK2;ERK1	Overexpression of ***JAK2*** was sufficient to ***activate*** both protein kinase B ( PKB ) and extracellular regulated kinase-1 ( ***ERK1*** ) .	positive	1
3594	10362354	3717;2185	JAK2;protein kinase B	Overexpression of ***JAK2*** was sufficient to ***activate*** both ***protein kinase B*** ( PKB ) and extracellular regulated kinase-1 ( ERK1 ) .	positive	1
3595	10362355	1399;25	CRKL;BCR/ABL	***CRKL*** ***binds*** directly to ***BCR/ABL*** through its N-terminal SH3 domain , suggesting it may be involved in BCR/ABL signal transduction .	parallel	1
3596	10362357	23624;1956	cbl-3;EGFR	These data demonstrate that ***cbl-3*** , a novel mammalian cbl protein , is a ***regulator*** of ***EGFR*** mediated signal transduction .	target	1
3597	10362515	6667;6688	Sp1;PU.1	This transactivation is mediated through adjacent binding sites rather than through the more distant Sp binding site , suggesting a possible direct ***interaction*** between ***PU.1*** and ***Sp1/3*** .	parallel	1
3598	10362515	6670;695	Sp3;Btk	Expression of Btk was found in ES cells and levels of expression were the same as in ES cells with a targeted deletion of the Sp1 gene , suggesting that ***Sp3*** acts as a positive ***regulator*** of ***Btk*** in vivo , in the absence of Sp1 .	positive	1
3599	10362518	51738;6750	growth hormone releasing peptide;somatostatin	Chimeric peptides consisting of ***growth hormone releasing peptide*** ( GHRP-6 ) ***linked*** to ***somatostatin*** ( 6-11 ) via an amide bond to provide the effector parts of both the peptides were synthesized .	parallel	0
3600	10362531	2357;1432	fMLP;p38	The concentration of SB 203580 that suppresses activation of NADPH oxidase is similar to that which inhibits SAPK2/p38 in vitro , and both ***fMLP*** and PMA ***induce*** an extremely rapid and potent activation of ***SAPK2/p38*** in neutrophils .	target	1
3601	10362531	2357;5600	fMLP;SAPK2	The concentration of SB 203580 that suppresses activation of NADPH oxidase is similar to that which inhibits SAPK2/p38 in vitro , and both ***fMLP*** and PMA ***induce*** an extremely rapid and potent activation of ***SAPK2/p38*** in neutrophils .	target	1
3602	10362533	3553;623	IL-1beta;BDKRB1	***BDKRB1*** mRNA expression in MH-S cells was ***increased*** by ***IL-1beta*** ( 1 , 3 , and 10 ng/ml ) in a time-dependent manner , peaking at 3-4 h by 100-1000 fold .	positive	0
3603	10362540	3316;2670	HSP27;glial fibrillary acidic protein	Here we report that ***HSP27*** like alphaB-crystallin is ***associated*** with ***glial fibrillary acidic protein*** and vimentin intermediate filament networks in unstressed U373MG astrocytoma cells .	parallel	0
3604	10362540	3316;7431	HSP27;vimentin	Here we report that ***HSP27*** like alphaB-crystallin is ***associated*** with glial fibrillary acidic protein and ***vimentin*** intermediate filament networks in unstressed U373MG astrocytoma cells .	parallel	0
3605	10362540	3316;2670	HSP27;GFAP	The transient transfection of GFAP into MCF7 cells was used to show that the induction of a completely separate network of intermediate filaments resulted in the specific ***association*** of the endogenous ***HSP27*** with these new ***GFAP*** filaments .	parallel	0
3606	10362602	7124;5502	TNF-alpha;inhibitor-1	***TNF-alpha*** and insulin , alone and synergistically , ***induce*** plasminogen activator ***inhibitor-1*** expression in adipocytes .	target	1
3607	10362652	2885;6464	Grb2;Shc	***Grb2*** ***association*** with ***Shc*** was demonstrated by blotting Grb2 immunoprecipitates with an anti-Shc antibody .	parallel	0
3608	10362694	3479;5294	IGF-I;PI3K	***IGF-I*** ***activated*** a wortmannin-sensitive ***PI3K*** and its purported effector , the atypical protein kinase C (PKC)-zeta .	positive	1
3609	10362694	3479;5590	IGF-I;protein kinase C (PKC)-zeta	***IGF-I*** ***activated*** a wortmannin-sensitive PI3K and its purported effector , the atypical ***protein kinase C (PKC)-zeta*** .	positive	1
3610	10362713	7124;3569	tumor necrosis factor (TNF)-alpha;IL-6	In contrast , ***tumor necrosis factor (TNF)-alpha*** ( 200 U/ml ) ***induced*** ***IL-6*** at the protein and mRNA levels in both airway epithelial cells and lung fibroblasts .	target	1
3611	10362723	7124;6347	TNF-alpha;MCP-1	The results support the hypothesis that ***TNF-alpha*** ***mediates*** cristobalite-induced ***MCP-1*** and MIP-2 expression through the generation of ROS .	target	0
3612	10362723	7124;2920	TNF-alpha;MIP-2	The results support the hypothesis that ***TNF-alpha*** ***mediates*** cristobalite-induced MCP-1 and ***MIP-2*** expression through the generation of ROS .	target	0
3613	10362724	2017;4638	cortactin;myosin light chain kinase	***Regulation*** of endothelial cell ***myosin light chain kinase*** by Rho , ***cortactin*** , and p60 ( src ) .	target	1
3614	10362724	7984;4638	p60;myosin light chain kinase	***Regulation*** of endothelial cell ***myosin light chain kinase*** by Rho , cortactin , and ***p60*** ( src ) .	target	1
3615	10362724	91807;2017	MLCK;cortactin	Immunoprecipitation of EC MLCK after DPV challenge revealed dramatic time-dependent tyrosine phosphorylation of the kinase in association with increased MLCK activity and a stable ***association*** of ***MLCK*** with the p85 actin-binding protein ***cortactin*** and p60 ( src ) .	parallel	0
3616	10362724	91807;7984	MLCK;p60	Immunoprecipitation of EC MLCK after DPV challenge revealed dramatic time-dependent tyrosine phosphorylation of the kinase in association with increased MLCK activity and a stable ***association*** of ***MLCK*** with the p85 actin-binding protein cortactin and ***p60*** ( src ) .	parallel	0
3617	10362724	7984;2017	p60;cortactin	These studies indicate that DPV activates the endothelial contractile apparatus in a Rho GTPase-dependent fashion and suggests that ***p60*** ( src ) - induced tyrosine ***phosphorylation*** of MLCK and ***cortactin*** may be important features of contractile complex assembly .	target	1
3618	10362724	7984;91807	p60;MLCK	These studies indicate that DPV activates the endothelial contractile apparatus in a Rho GTPase-dependent fashion and suggests that ***p60*** ( src ) - induced tyrosine ***phosphorylation*** of ***MLCK*** and cortactin may be important features of contractile complex assembly .	target	1
3619	10362800	7124;1520	TNF-alpha;cathepsin S	***TNF-alpha*** ***induced*** ***cathepsin S*** , MMP-1 , -3 , and -9 mRNA expression in a dose-dependent manner : the maximal effect was observed at a concentration of 10 ng/ml , with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml .	target	1
3620	10363677	3659;3456	interferon regulatory factor-1;IFN-beta	***IFN-beta*** expression can be ***activated*** by ***interferon regulatory factor-1*** ( IRF-1 ) and interferon-stimulated gene factor 3gamma ( ISGF3gamma ) .	positive	1
3621	10363677	3659;3620	IRF-1;IDO	It has been described that ***IRF-1*** can ***induce*** ***IDO*** gene expression .	target	1
3622	10363677	7124;3620	TNF-alpha;IDO	Infection of synovial fibroblasts alone in the absence of exogenous cytokine induced the expression of ***IDO*** mRNA which was ***enhanced*** by ***TNF-alpha*** treatment .	positive	0
3623	10363755	5054;3952	PAI-1;leptin	In postmenopausal females , a significant ***association*** between ***leptin*** and low tPA activity/high ***PAI-1*** activity was seen after adjustment for age and BMI ( P < 0.05 ) .	parallel	0
3624	10363755	5054;5327	PAI-1;tPA	In postmenopausal females , a significant ***association*** between leptin and low ***tPA*** activity/high ***PAI-1*** activity was seen after adjustment for age and BMI ( P < 0.05 ) .	parallel	0
3625	10363755	5327;3952	tPA;leptin	In postmenopausal females , a significant ***association*** between ***leptin*** and low ***tPA*** activity/high PAI-1 activity was seen after adjustment for age and BMI ( P < 0.05 ) .	parallel	0
3626	10363899	356;7124	FasL;TNF-alpha	Bacterial translocation and systemic endotoxemia have been reported after a burn injury , and Caspase-3 activation due to ***TNF-alpha*** and Fas ***ligand*** ( ***FasL*** ) are presumed to initiate apoptosis .	parallel	1
3627	10363928	7432;51083	VIP;Galanin	Addition of ***VIP*** or forskolin to the culture medium reduced Galanin mRNA expression by 75 % and 77 % , respectively , and ***reduced*** ***Galanin*** peptide expression by 76 % and 82 % , respectively , compared with ganglia cultured in control medium .	negative	1
3628	10363971	5728;207	PTEN;Akt	***Regulation*** of ***Akt/PKB*** activity , cellular growth , and apoptosis in prostate carcinoma cells by ***MMAC/PTEN*** .	target	1
3629	10363976	1029;1021	p16INK4a;Cdk4/6	To address this , we synthesized a peptidyl mimetic of the ***Cdk4/6*** ***inhibitor*** , ***p16INK4a*** that contained an NH2-terminal TAT protein transduction domain .	negative	1
3630	10363999	4087;4088	Smad2;Smad3	TGF-beta1-mediated receptor activation ***induces*** phosphorylation of ***Smad2*** and ***Smad3*** , which form complexes with Smad4 , that translocate to the nucleus to regulate transcription of target genes .	target	1
3631	10363999	4088;4087	Smad3;Smad2	TGF-beta1-mediated receptor activation ***induces*** phosphorylation of ***Smad2*** and ***Smad3*** , which form complexes with Smad4 , that translocate to the nucleus to regulate transcription of target genes .	target	1
3632	10364070	4023;7124	LPL;TNFalpha	Taken together , these data suggest that ( 1 ) differentiation of human monocytes to MDMs is associated with increased LPL-induced TNFalpha mRNA expression and production , ( 2 ) a protein kinase C-dependent pathway is involved in the ***induction*** of ***TNFalpha*** by ***LPL*** in these cells , and ( 3 ) LPL effect is mediated by cell surface proteoglycans .	target	1
3633	10364072	3565;6778	IL-4;Stat6	***IL-4*** also ***induced*** prolonged activation of ***Stat6*** , which was contingent on the continuous presence of IL-4 .	target	1
3634	10364076	6720;336	SREBP-1;ApoA-II	***SREBP-1*** mutants lacking the activation domain bind to their cognate sites and directly ***repress*** the ***ApoA-II*** promoter whereas mutants defective in DNA binding indirectly repress the ApoA-II promoter activity , possibly by a squelching mechanism .	positive	1
3635	10364076	6720;336	SREBP-1;ApoA-II	SREBP-1 binds to multiple sites and transactivates the human ApoA-II promoter in vitro : ***SREBP-1*** mutants defective in DNA binding or transcriptional activation ***repress*** ***ApoA-II*** promoter activity .	positive	1
3636	10364076	6720;336	SREBP-1;ApoA-II	***SREBP-1*** binds to multiple sites and ***transactivates*** the human ***ApoA-II*** promoter in vitro : SREBP-1 mutants defective in DNA binding or transcriptional activation repress ApoA-II promoter activity .	positive	1
3637	10364076	6720;336	SREBP-1;ApoA-II	Transient cotransfection experiments in HepG2 cells showed that ***SREBP-1*** ***transactivated*** the -911 / 29 ***ApoA-II*** promoter 3.5-fold as well as truncated ApoA-II promoter segments that contain 1 , 2 , 3 , or 4 SREBP binding sites .	positive	1
3638	10364076	6720;336	SREBP-1;ApoA-II	Despite the strong ***transactivation*** of the ***ApoA-II*** promoter by ***SREBP-1*** we could not demonstrate significant changes on the endogenous ApoA-II mRNA levels of HepG2 cells after cotransfection with SREBP-1 or in the presence or absence of cholesterol and 25-OH-cholesterol .	positive	1
3639	10364076	6720;336	SREBP-1;ApoA-II	An ***SREBP-1*** mutant lacking the amino-terminal activation domain bound normally to its cognate sites and ***repressed*** the ***ApoA-II*** promoter activity .	positive	1
3640	10364076	6720;336	SREBP-1;ApoA-II	Overall , the findings suggest that the wild-type ***SREBP-1*** can ***bind*** and transactivate efficiently the ***ApoA-II*** promoter in cell culture .	parallel	1
3641	10364093	4018;5054	lipoprotein;PAI-1	The consistent positive correlation between triglyceride and plasminogen activator inhibitor-1 ( PAI-1 ) levels in plasma and the fact that very low density ***lipoprotein*** ( VLDL ) ***induces*** secretion of ***PAI-1*** from cultured human umbilical vein endothelial cells ( HUVECs ) and human hepatoblastoma cells have raised the question of whether fibrate treatment , the main effect of which is a profound lowering of plasma concentrations of VLDL , might improve fibrinolytic function by reducing the plasma levels of PAI-1 .	target	1
3642	10364155	355;355	CD95;Fas	Both p53 and ******CD95/Fas****** ***signaling*** have been implicated in c-Myc-induced apoptosis but neither was required for c-Myc-induced cytochrome c release .	parallel	0
3643	10364157	6688;2623	PU.1;GATA-1	We find that ***PU.1*** ***interacts*** directly with ***GATA-1*** , a zinc finger transcription factor required for erythroid differentiation .	parallel	1
3644	10364157	6688;2623	PU.1;GATA-1	***Interaction*** between ***PU.1*** and ***GATA-1*** requires intact DNA-binding domains in both proteins .	parallel	1
3645	10364159	2475;1978	mTOR;4E-BP1	Taken together , our results suggest that ***4E-BP1*** ***phosphorylation*** by ***FRAP/mTOR*** on Thr-37 and Thr-46 is a priming event for subsequent phosphorylation of the carboxy-terminal serum-sensitive sites .	target	1
3646	10364159	2475;1978	mTOR;4E-BP1	***FRAP/mTOR*** has been reported to ***phosphorylate*** ***4E-BP1*** directly in vitro .	target	1
3647	10364159	2475;1978	mTOR;4E-BP1	To address these questions , a recombinant ***FRAP/mTOR*** protein and a FRAP/mTOR immunoprecipitate were utilized in in vitro kinase assays to ***phosphorylate*** ***4E-BP1*** .	target	1
3648	10364170	9267;375	sec7;ARF1	Physical ***interaction*** of the ***sec7*** domain with an ***ARF1*** mutant was demonstrated , but it was much weaker than that of the cytohesin-1 sec7 domain with the same ARF protein .	parallel	1
3649	10364173	4792;4790	IkappaB-alpha;NF-kappaB	Moreover , IGF-II induced , through a PI 3-kinase-dependent pathway , a decrease in IkappaB-alpha protein content that correlated with a decrease in the amount of ***IkappaB-alpha*** ***associated*** with p65 ***NF-kappaB*** .	parallel	0
3650	10364179	836;637	caspase-3;Bid	caspase-8 and ***caspase-3*** ***cleaved*** ***Bid*** , a proapoptotic Bcl-2 family member , which gains cytochrome c releasing activity in response to caspase cleavage .	target	1
3651	10364179	841;637	caspase-8;Bid	***caspase-8*** and caspase-3 ***cleaved*** ***Bid*** , a proapoptotic Bcl-2 family member , which gains cytochrome c releasing activity in response to caspase cleavage .	target	1
3652	10364184	6550;4036	NHE3;megalin	When immunoprecipitations were performed using either 10A3 or anti-NHE3 mAb 2B9 after separation of solubilized renal proteins by sucrose velocity gradient centrifugation , we found that NHE3 exists in two states with distinct sedimentation coefficients , a 9.6 S megalin-free form and a 21 S megalin-bound form , and that when ***NHE3*** ***assembles*** with ***megalin*** , epitopes within the carboxyl-terminal 131 amino acids of NHE3 are blocked .	parallel	1
3653	10364187	3952;5465	leptin;peroxisome proliferator-activated receptor (PPAR)-alpha	***leptin*** significantly lowered the mRNA of leptin and fatty acid synthase of adipocytes ( FAS ) ( p < 0.05 ) , and ***up-regulated*** the mRNA of ***peroxisome proliferator-activated receptor (PPAR)-alpha*** , carnitine palmitoyl transferase-1 , ( CPT-1 ) , and acyl CoA oxidase ( ACO ) ( p < 0.05 ) .	positive	1
3654	10364189	6532;821	SERT;calnexin	Functional expression of the unglycosylated SERT mutant , SERT-QQ , was also increased on co-expression of calnexin , suggesting that the ***interaction*** between ***calnexin*** and ***SERT*** is not entirely dictated by the N-glycan .	parallel	1
3655	10364189	821;811	calnexin;calreticulin	A physical ***interaction*** between ***Myc-SERT-calnexin*** and ***Myc-SERT-calreticulin*** was demonstrated by co-immunoprecipitation .	parallel	1
3656	10364189	821;6532	calnexin;SERT	A physical ***interaction*** between ***Myc-SERT-calnexin*** and ***Myc-SERT-calreticulin*** was demonstrated by co-immunoprecipitation .	parallel	1
3657	10364189	6532;811	SERT;calreticulin	A physical ***interaction*** between Myc-SERT-calnexin and ******Myc-SERT-calreticulin****** was demonstrated by co-immunoprecipitation .	parallel	1
3658	10364201	821;6521	Calnexin;AE1	The results show that the ***interaction*** of ***Calnexin*** with the polytopic membrane glycoprotein ***AE1*** was dependent on the presence but not the location of the oligosaccharide .	parallel	1
3659	10364201	821;6521	Calnexin;AE1	Furthermore , ***Calnexin*** was ***associated*** with ***AE1*** after release of AE1 from the translocation machinery .	parallel	0
3660	10364219	10928;5898	RLIP76;Ral	The Ral effector protein ***RLIP76*** ( also called RIP/RalBP1 ) ***binds*** to ***Ral.GTP*** via a region that shares no sequence homology with the Ras-binding domains of the Ser/Thr kinase c-Raf-1 and the Ral-specific guanine nucleotide exchange factors .	parallel	1
3661	10364242	8915;4790	CLAP;NF-kappaB	***CLAP*** , a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway , ***regulates*** ***NF-kappaB*** activation and apoptosis .	target	1
3662	10364245	1401;1432	CRP;p38 MAP kinase	Impressively , ***CRP-mediated*** ***inhibition*** of ***p38 MAP kinase*** activity correlated with CRP-mediated inhibition of fMLP-induced chemotaxis ( r = -0.7144 ) .	negative	1
3663	10364245	1401;1432	C-reactive protein;p38 mitogen-activated protein kinase	***C-reactive protein*** ***inhibits*** chemotactic peptide-induced ***p38 mitogen-activated protein kinase*** activity and human neutrophil movement .	negative	1
3664	10364245	1401;1432	CRP;p38 MAP kinase	More importantly , ***CRP*** ***inhibited*** fMLP-induced ***p38 MAP kinase*** activity in a concentration-dependent manner as measured by an in vitro kinase assay .	negative	1
3665	10364250	5915;3486	RARbeta;IGFBP-3	By using an RARalpha-selective antagonist ( Ro 41-5253 ) , we demonstrated that RARbeta expression was induced by atRA through an RARalpha-dependent signaling pathway and that ***RARbeta*** induction was ***correlated*** with ***IGFBP-3*** induction .	parallel	0
3666	10364250	5915;3486	RARbeta;IGFBP-3	On the other hand , antisense ***RARbeta*** cDNA transfection of MCF-7 cells ***blocked*** atRA-induced ***IGFBP-3*** expression , indicating that RARbeta is directly involved in the mediation of IGFBP-3 induction by atRA .	negative	0
3667	10364250	3486;5915	IGFBP-3;RARbeta	By ***linking*** ***IGFBP-3*** to ***RARbeta*** , our experiments define the signal intersection between the retinoid and IGF systems in cell growth regulation and explain why loss of RARbeta might be critical in breast cancer carcinogenesis/progression .	parallel	0
3668	10364266	5864;115827	Rab3a;Rab3c	Binding constants for the ***interaction*** of the GTP-bound forms of ***Rab3a*** , Rab3b , ***Rab3c*** , and Rab3d with Rabphilin3 were comparable ( Kd = 10-20 nM ) .	parallel	1
3669	10364266	5865;5864	Rab3b;Rab3a	Binding constants for the ***interaction*** of the GTP-bound forms of ***Rab3a*** , ***Rab3b*** , Rab3c , and Rab3d with Rabphilin3 were comparable ( Kd = 10-20 nM ) .	parallel	1
3670	10364266	5865;115827	Rab3b;Rab3c	Binding constants for the ***interaction*** of the GTP-bound forms of Rab3a , ***Rab3b*** , ***Rab3c*** , and Rab3d with Rabphilin3 were comparable ( Kd = 10-20 nM ) .	parallel	1
3671	10364266	9545;5864	Rab3d;Rab3a	Binding constants for the ***interaction*** of the GTP-bound forms of ***Rab3a*** , Rab3b , Rab3c , and ***Rab3d*** with Rabphilin3 were comparable ( Kd = 10-20 nM ) .	parallel	1
3672	10364266	9545;5865	Rab3d;Rab3b	Binding constants for the ***interaction*** of the GTP-bound forms of Rab3a , ***Rab3b*** , Rab3c , and ***Rab3d*** with Rabphilin3 were comparable ( Kd = 10-20 nM ) .	parallel	1
3673	10364266	9545;115827	Rab3d;Rab3c	Binding constants for the ***interaction*** of the GTP-bound forms of Rab3a , Rab3b , ***Rab3c*** , and ***Rab3d*** with Rabphilin3 were comparable ( Kd = 10-20 nM ) .	parallel	1
3674	10364284	79966;920	sCD4;CD4	A soluble form of the ***CD4*** ***receptor*** ( ***sCD4*** ) can either enhance or inhibit the infection of cells by simian immunodeficiency virus ( SIV ) and human immunodeficiency virus .	parallel	1
3675	10364288	10044;1981	NSP3;eIF4GI	***NSP3*** also ***interacts*** with the translation initiation factor ***eIF4GI*** and competes with the poly ( A ) binding protein .	parallel	1
3676	10364292	1025;904	CDK9;cyclin T1	Rodent ( mouse and Chinese hamster ) cyclin T1 is defective in Tat binding and transactivation , but hamster ***CDK9*** ***interacts*** with human ***cyclin T1*** to give active TAK in hybrid cells containing human chromosome 12 .	parallel	1
3677	10364318	4049;8764	lymphotoxin-alpha;HveA	Inhibition of herpes simplex virus gD and ***lymphotoxin-alpha*** ***binding*** to ***HveA*** by peptide antagonists .	parallel	1
3678	10364318	8764;4049	HveA;LT-alpha	When we analyzed these peptides for the ability to interfere with ***HveA*** ***binding*** to its natural ligand ***LT-alpha*** , we found that BP-1 inhibited the interaction of cellular LT-alpha with HveA .	parallel	1
3679	10364318	4049;8764	LT-alpha;HveA	When we analyzed these peptides for the ability to interfere with HveA binding to its natural ligand LT-alpha , we found that BP-1 inhibited the ***interaction*** of cellular ***LT-alpha*** with ***HveA*** .	parallel	1
3680	10364318	1978;4049	BP-1;LT-alpha	When we analyzed these peptides for the ability to interfere with HveA binding to its natural ligand LT-alpha , we found that ***BP-1*** ***inhibited*** the interaction of cellular ***LT-alpha*** with HveA .	negative	1
3681	10364370	821;811	calnexin;calreticulin	Stable ***complexes*** between G1-G2 and ***calnexin*** or ***calreticulin*** could be immunoprecipitated after solubilization of virus-infected BHK21 cells with the detergents digitonin or Triton X-100 .	parallel	1
3682	10364424	5075;2303	PAX1;MFH1	Notochord-dependent expression of ***MFH1*** and ***PAX1*** ***cooperates*** to maintain the proliferation of sclerotome cells during the vertebral column development .	parallel	0
3683	10364424	2303;5075	MFH1;PAX1	Thus , both the ***MFH1*** and the ***PAX1*** gene products ***cooperate*** to mediate Sonic hedgehog-dependent proliferation of sclerotome cells .	parallel	0
3684	10364428	4254;3815	stem cell factor;c-kit	The Sl locus encodes ***stem cell factor*** ( SCF ) , which is the ***ligand*** of ***c-kit*** , a receptor tyrosine kinase encoded by the W locus .	parallel	1
3685	10364447	5443;4792	alpha-melanocyte-stimulating hormone;IkappaBalpha	***alpha-melanocyte-stimulating hormone*** ***inhibits*** NF-kappaB activation and ***IkappaBalpha*** degradation in human glioma cells and in experimental brain inflammation .	negative	1
3686	10364447	5443;4790	alpha-melanocyte-stimulating hormone;NF-kappaB	***alpha-melanocyte-stimulating hormone*** ***inhibits*** ***NF-kappaB*** activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation .	negative	1
3687	10364447	5443;4790	alpha-MSH;NF-kappaB	Electrophoretic mobility shift assays of nuclear extracts from A-172 cells and whole mouse brains stimulated with LPS revealed that ***alpha-MSH*** does ***suppress*** ***NF-kappaB*** activation .	negative	1
3688	10364455	7040;5706	TGFbeta;p44	***TGFbeta*** ***induced*** ***p42/p44*** MAP kinase activities .	target	1
3689	10364461	7341;989	Smt3;Cdc3	***Smt3*** , a SUMO-1 homolog , is ***conjugated*** to ***Cdc3*** , a component of septin rings at the mother-bud neck in budding yeast .	parallel	1
3690	10364461	7341;989	Smt3;Cdc3	Thus , we conclude that ***Smt3*** was ***conjugated*** to ***Cdc3*** in septin rings localized at the mother-bud neck .	parallel	1
3691	10364466	4145;4067	CHK;Lyn	***CHK*** ***down-regulates*** SCF/KL-activated ***Lyn*** kinase activity in Mo7e megakaryocytic cells .	negative	1
3692	10364466	4145;4067	CHK;Lyn	Taken together , these findings show that ***CHK*** is able to ***down-regulate*** SCF/KL-stimulated ***Lyn*** activity in megakaryocytes .	negative	1
3693	10364477	10544;5624	protein C receptor;protein C	The endothelial cell ***protein C receptor*** ( EPCR ) functions as a primary ***receptor*** for ***protein C*** activation on endothelial cells in arteries , veins , and capillaries .	parallel	1
3694	10364477	10544;5624	EPCR;protein C	These results indicate that ***EPCR*** functions as an important ***regulator*** for the ***protein C*** pathway in various types of vessels .	target	1
3695	10364484	7852;920	CXCR4;CD4	A mechanism of resistance to HIV-1 entry : inefficient ***interactions*** of ***CXCR4*** with ***CD4*** and gp120 in macrophages .	parallel	1
3696	10364484	7852;3700	CXCR4;gp120	A mechanism of resistance to HIV-1 entry : inefficient ***interactions*** of ***CXCR4*** with CD4 and ***gp120*** in macrophages .	parallel	1
3697	10364484	7852;920	CXCR4;CD4	To test the hypothesis that inefficient ***interactions*** of ***CXCR4*** with ***CD4*** and gp120 could affect HIV-1 entry , we incubated macrophages , monocytes , and lymphocytes with gp120 and coimmunoprecipitated CD4 by using anti-CXCR4 antibodies .	parallel	1
3698	10364484	7852;3700	CXCR4;gp120	To test the hypothesis that inefficient ***interactions*** of ***CXCR4*** with CD4 and ***gp120*** could affect HIV-1 entry , we incubated macrophages , monocytes , and lymphocytes with gp120 and coimmunoprecipitated CD4 by using anti-CXCR4 antibodies .	parallel	1
3699	10364484	920;7852	CD4;CXCR4	Overexpression of CD4 in macrophages resulted in detection of CD4-CXCR4 and ******gp120-CD4-CXCR4****** ***complexes*** in parallel with the restoration of macrophage fusion susceptibility .	parallel	1
3700	10364484	3700;920	gp120;CD4	Overexpression of CD4 in macrophages resulted in detection of CD4-CXCR4 and ******gp120-CD4-CXCR4****** ***complexes*** in parallel with the restoration of macrophage fusion susceptibility .	parallel	1
3701	10364484	3700;7852	gp120;CXCR4	Overexpression of CD4 in macrophages resulted in detection of CD4-CXCR4 and ******gp120-CD4-CXCR4****** ***complexes*** in parallel with the restoration of macrophage fusion susceptibility .	parallel	1
3702	10364543	7401;4647	USH3;USH1B	Possible ***interaction*** between ***USH1B*** and ***USH3*** gene products as implied by apparent digenic deafness inheritance .	parallel	1
3703	10364571	6714;3717	c-Src;Jak2	The angiotensin II-dependent ***association*** of ***Jak2*** and ***c-Src*** requires the N-terminus of Jak2 and the SH2 domain of c-Src .	parallel	0
3704	10364571	183;185	angiotensin II;AT1	The ***binding*** of ***angiotensin II*** ( Ang II ) to ***AT1*** is known to increase the kinase activity of several nonreceptor tyrosine kinases including Jak2 and c-Src .	parallel	1
3705	10364571	3717;6714	Jak2;c-Src	In the present study , we demonstrate that treatment of vascular smooth muscle cells with Ang II results in a rapid and transient ***association*** of ***Jak2*** and ***c-Src*** .	parallel	0
3706	10364571	3717;6714	Jak2;c-Src	Lastly , using transiently transfected COS-7 cells , we found that Ang II treatment induced an ***association*** between ***c-Src*** and wild-type Jak2 but not between c-Src and the ***Jak2*** molecule that lacks the initial 240 amino acids .	parallel	0
3707	10364571	3717;6714	Jak2;c-Src	Thus , our data suggest that in addition to increasing the kinase activities Jak2 and c-Src , treatment of cells with Ang II results in the physical ***association*** of ***Jak2*** and ***c-Src*** ; an association that is mediated by the SH2 domain of c-Src and the N-terminus of Jak2 .	parallel	0
3708	10364692	3479;6750	IGF-I;somatostatin	There were no significant alterations in hypothalamic IR growth hormone releasing factor content , although IR ***somatostatin*** ( SRIH ) content was ***increased*** by ***IGF-I-Ab*** .	positive	0
3709	10364693	3953;4852	leptin receptor;NPY	Full-length ***leptin receptor*** expression in the arcuate nucleus was negatively ***correlated*** with neuropeptide Y ( ***NPY*** ) expression ( r = 0.447 , p < 0 .	negative	0
3710	10364831	7124;4790	TNF-alpha;NF-kappa B	Here we show that micromolar concentrations of hypericin inhibited the PMA - and ***TNF-alpha-induced*** ***activation*** of ***NF-kappa B*** in HeLa and TC10 cells , respectively .	positive	1
3711	10365089	999;1956	E-cadherin;epidermal growth factor receptor	The ******E-cadherin/epidermal growth factor receptor****** ***interaction*** : a hypothesis of reciprocal and reversible control of intercellular adhesion and cell proliferation .	parallel	1
3712	10365096	7157;7153	p53;topoisomerase II alpha	Both ***p53*** and c-erbB-2 were significantly ***associated*** with high tumour grade , large tumour size , DNA aneuploidy , lack of steroid hormone receptors , young age , and increased ***topoisomerase II alpha*** and Ki-67 expression levels .	parallel	0
3713	10365570	4314;1401	MMP-3;C-reactive protein	In JRA , MMP-3 levels of patients with arthritis were statistically higher than those of patients without arthritis ( P < 0.05 ) and ***MMP-3*** levels were ***correlated*** with ***C-reactive protein*** ( rs = 0.465 , P < 0.05 ) , while TIMP-1 did not ( rs = 0.340 ) .	parallel	0
3714	10365667	959;958	CD40 ligand;CD40	***CD40 ligand*** ( CD40L ) , the ***ligand*** for ***CD40*** on antigen-presenting cells , is essential for the initiation of antigen-specific T cell responses , an important component of the immune response to tumors .	parallel	1
3715	10365830	3569;213	IL-6;albumin	High concentrations of CRP ( > or = 60mg/L ) were associated with low albumin concentrations ( 33 [ 5 ] g/L ) ; high alpha-1 antitrypsin concentrations ( > or = 4.0 g/L ) were associated with low albumin concentrations ( 34 [ 6 ] g/L ) ; and high ***IL-6*** concentrations ( > or = 4pg/ml ) were ***associated*** with low ***albumin*** concentrations ( 37 [ 6 ] g/L ) compared with a mean ( SD ) albumin concentration of 40 ( 5 ) g/L in patients who had no evidence of an acute phase response .	parallel	0
3716	10365917	5747;5829	FAK;paxillin	Surprisingly , the ***association*** between ***FAK*** and ***paxillin*** was enhanced in B104-1-1 cells , suggesting reorganization of protein-protein interaction modulated by protein phosphorylation .	parallel	0
3717	10366100	7157;3569	p53;IL-6	The mutant ***p53*** genes also ***increased*** ***IL-6*** gene expression .	positive	0
3718	10366107	3596;4322	IL-13;Collagenase 3	***IL-13*** ***inhibited*** ***Collagenase 3*** production , IL-4 had little effect , and IL-10 had none .	negative	1
3719	10366413	7039;3479	transforming growth factor-alpha;IGF-I	***IGF-I*** production by adult rat hepatocytes is ***stimulated*** by ***transforming growth factor-alpha*** and transforming growth factor-beta1 .	positive	0
3720	10366413	7039;3479	TGF-alpha;IGF-I	Our results demonstrate that ***TGF-alpha*** and TGF-beta1 significantly ***stimulate*** ***IGF-I*** and IGFBP secretion by cultured hepatocytes but no change in the abundance of IGF-I and IGFBP mRNAs was observed with respect to controls .	positive	0
3721	10366413	7040;3479	TGF-beta1;IGF-I	Our results demonstrate that TGF-alpha and ***TGF-beta1*** significantly ***stimulate*** ***IGF-I*** and IGFBP secretion by cultured hepatocytes but no change in the abundance of IGF-I and IGFBP mRNAs was observed with respect to controls .	positive	0
3722	10366414	5617;4312	prolactin;MMP-1	However , an intraperitoneal injection of bovine ***prolactin*** at the time when the preovulatory prolactin surge occurs normally , ***increased*** ***MMP-1*** and TIMP-1 gene expression ( P < 0.01 ) .	positive	0
3723	10366414	5617;7076	prolactin;TIMP-1	However , an intraperitoneal injection of bovine ***prolactin*** at the time when the preovulatory prolactin surge occurs normally , ***increased*** MMP-1 and ***TIMP-1*** gene expression ( P < 0.01 ) .	positive	0
3724	10366442	1020;595	Cdk5;cyclin D1	Active or inactive ***Cdk5*** was ***associated*** with ***cyclin D1*** , but only active Cdk5 exhibited threonine phosphorylation .	parallel	0
3725	10366588	23534;10921	TRN-SR;SR protein	These findings strongly suggest that ***TRN-SR*** is a nuclear import ***receptor*** for the ***SR protein*** family .	parallel	1
3726	10366609	8801;8802	Gbeta;Galpha	In conclusion , coupling specificity in signal transduction is unlikely to arise as a result of restricted ******Galpha/Gbeta****** gamma ***interaction*** .	parallel	1
3727	10366611	10497;6812	UNC-13;UNC-18	***Regulation*** of the ***UNC-18-Caenorhabditis*** elegans syntaxin complex by ***UNC-13*** .	target	1
3728	10366611	10497;6812	UNC-13;UNC-18	We show that ***UNC-13*** transiently ***interacts*** with the ***UNC-18-Ce*** syntaxin complex , resulting in rapid displacement of UNC-18 from the complex .	parallel	1
3729	10366624	7099;6103	TOLL;RP3	***TOLL*** and FAS3 , putative " negative " and " positive " recognition molecules , respectively , ***affect*** ***RP3*** antagonistically .	target	0
3730	10366627	4917;1630	Netrin-3;DCC	Unlike chick netrin-1 , however , murine ***Netrin-3*** ***binds*** to ***DCC*** with lower affinity than to the other four receptors .	parallel	1
3731	10366629	1942;2043	Ephrin-A1;EphA4	Ligand-receptor binding assays indicate that ***Ephrin-A1*** and ephrin-A4 selectively ***bind*** ***EphA4*** but not EphA7 in the lysates of striatal tissue .	parallel	1
3732	10366629	1945;2043	ephrin-A4;EphA4	Ligand-receptor binding assays indicate that Ephrin-A1 and ***ephrin-A4*** selectively ***bind*** ***EphA4*** but not EphA7 in the lysates of striatal tissue .	parallel	1
3733	10366629	1943;2045	ephrin-A2;EphA7	Conversely , ***ephrin-A2*** , ephrin-A3 , and ephrin-A5 ***bind*** ***EphA7*** but not EphA4 .	parallel	1
3734	10366629	1944;2045	ephrin-A3;EphA7	Conversely , ephrin-A2 , ***ephrin-A3*** , and ephrin-A5 ***bind*** ***EphA7*** but not EphA4 .	parallel	1
3735	10366629	1946;2045	ephrin-A5;EphA7	Conversely , ephrin-A2 , ephrin-A3 , and ***ephrin-A5*** ***bind*** ***EphA7*** but not EphA4 .	parallel	1
3736	10366647	627;2353	BDNF;c-fos	***BDNF*** , localized in primary sensory neuron cell bodies and central terminals , potentiates nociceptive spinal reflex responses in an in vitro spinal cord preparation and ***induces*** ***c-fos*** expression in dorsal horn neurons .	target	1
3737	10366647	4803;627	NGF;BDNF	Systemic ***NGF*** treatment , a procedure that mimics peripheral inflammatory states , ***raises*** ***BDNF*** levels in sensory neurons and increases nociceptive spinal reflex excitability .	positive	0
3738	10366690	7124;3383	TNF-alpha;ICAM-1	Tumour necrosis factor-alpha ( ***TNF-alpha*** ) , which is elevated in MS and CM , decreased the integrity of the barrier in co-cultured endothelial cells and ***upregulated*** the expression of ***ICAM-1*** nine-fold .	positive	1
3739	10366699	4915;627	TrkB;BDNF	These results suggest that ***TrkB*** , a functional high-affinity ***receptor*** of ***BDNF*** and NT-4 / 5 , and LIFR beta , a receptor component contained in CNTF and LIF receptor complex , might be involved in the observed synergistic effects .	parallel	1
3740	10366699	1270;4909	CNTF;neurotrophin-4	***CNTF*** also ***enhanced*** the ***neurotrophin-4*** / 5-mediated increase of ChAT activity , but not the nerve growth factor ( NGF ) - mediated one .	positive	0
3741	10366730	1471;1514	cystatin C;cathepsin L	Notably , the affinity of bovine cystatin C for cathepsin H was somewhat weaker than that of human cystatin C , and bovine ***cystatin C*** ***bound*** to ***cathepsin L*** with about a four-fold higher association rate constant than the human inhibitor .	parallel	1
3742	10366748	5663;4851	presenilin 1;notch 1	The Alzheimer-related gene ***presenilin 1*** ***facilitates*** ***notch 1*** in primary mammalian neurons .	positive	0
3743	10366748	5663;4851	PS1;Notch1	Furthermore , we present evidence demonstrating that there is a functional ***interaction*** between ***PS1*** and ***Notch1*** in mammalian neurons , analogous to the sel-12 / lin-12 interaction in vulval development in C. elegans [ D.	parallel	1
3744	10366748	5663;4851	PS1;Notch1	These data suggest that ***PS1*** ***facilitates*** ***Notch1*** function in mammalian neurons , and support the hypothesis that a functional interaction exists between PS1 and Notch1 in postmitotic mammalian neurons .	positive	0
3745	10366761	2520;3030	gastrin;GBP	In order to investigate the structural requirements for binding to the GBP , 26 analogues of sulindac sulphide and sulindac sulphoxide were tested for their ability to inhibit the ***binding*** of iodinated ***gastrin*** to the ***GBP*** .	parallel	1
3746	10366775	4018;338	lipoprotein;apoB-100	***lipoprotein*** ( a ) [ Lp ( a ) ] is a ***heterodimer*** of apolipoprotein ( a ) [ Apo ( a ) ] and apolipoprotein B-100 ( ***apoB-100*** ) of low density lipoprotein linked by a disulfide bond .	parallel	1
3747	10366852	10645;207	CaMKK;PKB	***Activation*** of ***PKB*** by ***CaMKK*** appears to be important in protection of neurons from programmed cell death during development .	positive	1
3748	10367743	596;581	Bcl-2;Bax	Surprisingly , ***Bcl-2*** also ***blocked*** ***Bax*** membrane insertion .	negative	0
3749	10367887	672;1647	BRCA1;GADD45	The p53-independent ***induction*** of ***GADD45*** by ***BRCA1*** and its activation of JNK/SAPK suggest a pathway for BRCA1-induced apoptosis .	target	1
3750	10367898	3574;207	IL-7;PKB	We show that ***IL-7*** ***activates*** ***PKB*** and STAT5 in human thymocytes .	positive	1
3751	10368124	5502;5327	inhibitor-1;tPA	Plasminogen activator ***inhibitor-1*** ( PAI-1 ) , a rapid ***inhibitor*** of ***tPA*** , may contribute to arterial thrombolysis resistance .	negative	1
3752	10368277	4790;4792	NFkappaB;IkappaBalpha	A firm hand on NFkappaB : structures of the ******IkappaBalpha-NFkappaB****** ***complex*** .	parallel	1
3753	10368775	8792;8600	RANK;RANKL	Osteoclast precursors express ***RANK*** , a TNF receptor family member , ***recognize*** ***RANKL*** through cell-to-cell interaction with osteoblasts/stromal cells , and differentiate into pOCs in the presence of M-CSF .	target	1
3754	10368775	4982;8600	OPG;RANKL	***OPG*** , which has also been called OCIF or TR1 , is a soluble ***receptor*** for ***RANKL*** and acts as a decoy receptor in the RANK-RANKL signaling system ( Fig .	parallel	1
3755	10369079	596;4609	Bcl-2;c-Myc	Synergistic ***cooperation*** between ***c-Myc*** and ***Bcl-2*** in lymph node progression of T1 human breast carcinomas .	parallel	0
3756	10369126	3956;5788	Galectin-1;CD45	***Galectin-1*** , a natural ***ligand*** for the receptor-type protein tyrosine phosphatase ***CD45*** .	parallel	1
3757	10369126	3956;5788	Galectin-1;CD45	In the present work , placental ***Galectin-1*** has been identified to be a natural ***ligand*** for the receptor-type protein tyrosine phosphatase ***CD45*** .	parallel	1
3758	10369126	3956;5788	Galectin-1;CD45	The ***binding*** of ***Galectin-1*** to ***CD45*** was detected by affinity chromatography of NP 40 solubilized Jurkat T cell membranes on Galectin-1 agarose followed by immunoblotting of the Galectin-1 agarose bound fraction applying monoclonal antibodies to CD45 isoforms .	parallel	1
3759	10369131	3553;4254	IL-1;SCF	TNF + ***IL-1*** significantly ***decreased*** the secretion of ***SCF*** by AFb .	negative	0
3760	10369418	6778;4790	STAT6;NF-kappaB	In addition , activation of the promoter by IL-4 was blocked by mutation of all three NF-kappaB sites and similarly reduced by mutation of site 1 , suggesting that ******NF-kappaB-STAT6****** ***interactions*** may be necessary for STAT6-mediated transactivation of the germline gamma1 promoter .	parallel	1
3761	10369419	3566;653361	interleukin-4 receptor alpha chain;p47phox	***Association*** of the ***interleukin-4 receptor alpha chain*** with ***p47phox*** , an activator of the phagocyte NADPH oxidase in B cells .	parallel	0
3762	10369455	4843;5320	inducible NO-synthase;group IIA-phospholipase A2	***Cross-talk*** between ***group IIA-phospholipase A2*** and ***inducible NO-synthase*** in rat renal mesangial cells .	parallel	0
3763	10369472	728;8288	C5a;eosinophil peroxidase	In the presence of cytochalasin B ( CB ) , ***C5a*** ***induced*** a dose-dependent release of the granular ***eosinophil peroxidase*** ( EPO ) , but not O2 - , whereas in the absence of CB O2 - , but not EPO , was released .	target	1
3764	10369675	2065;2064	ErbB-3;ErbB-2	Consistent with the possibility that this domain recruits a relatively potent signaling pathway ( s ) , the mitogenic signals generated by the recombinant fusion protein were superior to those generated by ErbB-1 homodimers and comparable to the proliferative activity of ******ErbB-2/ErbB-3****** ***heterodimers*** .	parallel	1
3765	10369680	10107;84733	Zn finger protein;M33	We have identified a new ***Zn finger protein*** , RYBP , which ***interacts*** directly with both Ring1 proteins ( Ring1A and Ring1B ) and with ***M33*** , two mutually interacting sets of proteins of the mammalian Polycomb complex .	parallel	1
3766	10369680	10107;6015	Zn finger protein;Ring1	We have identified a new ***Zn finger protein*** , RYBP , which ***interacts*** directly with both ***Ring1*** proteins ( Ring1A and Ring1B ) and with M33 , two mutually interacting sets of proteins of the mammalian Polycomb complex .	parallel	1
3767	10369680	23429;84733	RYBP;M33	Ring1 binds RYBP and M33 through the same C-terminal domain , whereas the ******RYBP-M33****** ***interaction*** takes place through an M33 domain not involved in Ring1 binding .	parallel	1
3768	10369680	6015;84733	Ring1;M33	***Ring1*** ***binds*** RYBP and ***M33*** through the same C-terminal domain , whereas the RYBP-M33 interaction takes place through an M33 domain not involved in Ring1 binding .	parallel	1
3769	10369680	6015;23429	Ring1;RYBP	***Ring1*** ***binds*** ***RYBP*** and M33 through the same C-terminal domain , whereas the RYBP-M33 interaction takes place through an M33 domain not involved in Ring1 binding .	parallel	1
3770	10369680	23429;7528	RYBP;YY1	***RYBP*** also ***interacts*** directly with ***YY1*** , a transcription factor partially related to the product of the Drosophila pleiohomeotic gene .	parallel	1
3771	10369681	3558;22806	IL-2;Aiolos	Indirect immunofluorescence shows that ***IL-2*** ***controls*** the cellular distribution of ***Aiolos*** and induces its tyrosine phosphorylation , required for dissociation from Ras .	target	0
3772	10369681	22806;596	Aiolos;Bcl-2	Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase , suggesting direct ***control*** of ***Bcl-2*** expression by ***Aiolos*** .	target	0
3773	10369681	22806;596	Aiolos;Bcl-2	Co-transfection experiments confirm that ***Aiolos*** ***induces*** ***Bcl-2*** expression and prevents apoptosis in IL-2-deprived cells .	target	1
3774	10369681	22806;596	Aiolos;Bcl-2	We propose a model for the ***regulation*** of ***Bcl-2*** expression via ***Aiolos*** .	target	1
3775	10369682	5307;2516	Ptx1;SF-1	***Ptx1*** ***regulates*** ***SF-1*** activity by an interaction that mimics the role of the ligand-binding domain .	target	1
3776	10369682	5307;2516	Ptx1;SF-1	The ***interaction*** between the C-terminus of ***Ptx1*** and the N-terminal half of ***SF-1*** results in transcriptional enhancement that equals the activity of a constitutively active SF-1 mutant and that may mimic the effect of a still unidentified SF-1 ligand .	parallel	1
3777	10369783	3329;3336	GroEL;GroES	To achieve this , the ***cooperation*** of ***GroEL*** and ***GroES*** , the two protein components of the chaperone system , is an essential requirement .	parallel	0
3778	10369785	3077;7037	HFE;transferrin receptor	***HFE*** ***binds*** tightly to ***transferrin receptor*** ( TfR ) , the receptor that mediates uptake of iron-loaded transferrin .	parallel	1
3779	10369785	7037;3077	TfR;HFE	A biosensor-derived pH-dependent affinity profile for the ******HFE-TfR****** ***interaction*** is discussed in terms of HFE 's hypothesized role in intracellular trafficking .	parallel	1
3780	10370370	3586;1234	IL-10;CCR5	Regulation of CCR5 and CXCR4 expression by type 1 and type 2 cytokines : ***CCR5*** expression is ***downregulated*** by ***IL-10*** in CD4-positive lymphocytes .	negative	1
3781	10370370	3586;1234	IL-10;CCR5	The type 2 cytokine ***IL-10*** ***downregulated*** both ***CCR5*** mRNA and protein expression in wt/wt and wt/del individuals .	negative	1
3782	10370375	940;941	CD28;B7-1	***CD28*** , a ***receptor*** for ***B7-1*** which activates T cells , is upregulated in B6/lpr and B6/gld mice , while CTLA4 , a negative regulator of T cells which binds B7-1 , is not .	parallel	1
3783	10371193	5170;207	3-phosphoinositide-dependent protein kinase-1;AKT	Arabidopsis ***3-phosphoinositide-dependent protein kinase-1*** is able to ***activate*** human protein kinase B alpha ( ***PKB/AKT*** ) in the presence of PtdIns ( 3,4,5 ) P3 .	positive	1
3784	10371251	581;596	Bax;Bcl-2	The function of the Bax-Bax dimer in active cell death is antagonized by ******Bax-Bcl-2****** ***heterodimers*** .	parallel	1
3785	10371349	3791;7422	KDR;vascular endothelial growth factor	In this study , we examined the protein expression of ***vascular endothelial growth factor*** ( VEGF ) and its specific and functional ***receptor*** ***KDR*** in human breast tissue .	parallel	1
3786	10371394	6855;3667	Syp;IRS-1	In addition , ethanol exposure may preferentially inhibit downstream signaling that requires ***interaction*** between ***Syp*** and ***PY-IRS-1*** .	parallel	1
3787	10371508	959;958	CD154;CD40	***CD154*** is the ***ligand*** for the receptor ***CD40*** .	parallel	1
3788	10371521	3456;3458	Interferon beta;IFNgamma	***Interferon beta-1b*** treatment ***modulates*** TNFalpha and ***IFNgamma*** spontaneous gene expression in MS.	target	0
3789	10371521	3456;7124	Interferon beta;TNFalpha	***Interferon beta-1b*** treatment ***modulates*** ***TNFalpha*** and IFNgamma spontaneous gene expression in MS.	target	0
3790	10372132	1437;3717	GM-CSF;JAK2	Binding of ***GM-CSF*** ***activates*** at least one receptor-associated tyrosine kinase , ***JAK2*** , and rapidly induces tyrosine phosphorylation of the GMR beta c chain ( GMR beta ) , but not the GMR alpha chain ( GMR alpha ) .	positive	1
3791	10372132	1437;5781	GM-CSF;SHP2	Tyrosine 577 was found to be sufficient to regenerate GM-CSF-dependent phosphorylation of SHC , and any of Y577 , Y612 , or Y695 were sufficient to regenerate ***GM-CSF-inducible*** ***phosphorylation*** of ***SHP2*** .	target	1
3792	10372738	5443;1392	adrenocorticotropin;corticotropin-releasing hormone	Desmopressin normalizes the blunted ***adrenocorticotropin*** ***response*** to ***corticotropin-releasing hormone*** in melancholic depression : evidence of enhanced vasopressinergic responsivity .	parallel	0
3793	10372803	4690;867	Nck;Cbl	By means of affinity purification with the Nck-binding phosphopeptide EPGPY ( P ) AQPSV , we could also detect the ***association*** of endogenous ***Nck*** with the proto-oncogene product ***Cbl*** .	parallel	0
3794	10372806	342897;3717	NCCRP-1;JAK2	To determine if ***NCCRP-1*** was physically ***associated*** with ***JAK2*** kinase , chemical cross-linking experiments were conducted .	parallel	0
3795	10372815	2150;4790	PAR-2;NFkappaB	***Activation*** of ***NFkappaB*** via either PAR-1 or ***PAR-2*** does not predict mitogenesis .	positive	1
3796	10372835	7421;5741	vitamin D receptor;PTH	Different ***vitamin D receptor*** genotypes may be ***associated*** with higher levels of serum ***PTH*** and a predisposition to autonomous hyperplasia .	parallel	0
3797	10372988	5015;5949	OTX2;IRBP	Since no clones for the homeodomain protein CRX were found , and since OTX2 can transcriptionally activate IRBP in normally non-expressing HeLa cells , it is possible that ***OTX2*** rather than CRX is the transcriptional ***activator*** for ***IRBP*** in human photoreceptors .	positive	1
3798	10372988	5015;5949	OTX2;IRBP	Since no clones for the homeodomain protein CRX were found , and since ***OTX2*** can transcriptionally ***activate*** ***IRBP*** in normally non-expressing HeLa cells , it is possible that OTX2 rather than CRX is the transcriptional activator for IRBP in human photoreceptors .	positive	1
3799	10372988	8517;5015	IP1;OTX2	The core promoter element ***IP1*** ***binds*** to ***OTX2*** in the yeast one-hybrid system .	parallel	1
3800	10372988	5015;5949	OTX2;IRBP	By cotransfecting HeLa cells , ***OTX2*** could ***transactivate*** the ***IRBP*** promoter .	positive	1
3801	10372988	5015;5949	OTX2;IRBP	The region containing the HeLa cell-specific footprint IP4 ( from -202 to -180 ) could silence the ***OTX2*** ***transactivation*** of the ***IRBP*** promoter .	positive	1
3802	10372996	3553;6347	IL-1beta;MCP-1	HRPE IL-8 and ***MCP-1*** gene expression and protein production are ***stimulated*** by ***IL-1beta*** or TNF-alpha through pathways differentially modulated by IL-4 and GM-CSF .	positive	0
3803	10372996	7124;6347	TNF-alpha;MCP-1	HRPE IL-8 and ***MCP-1*** gene expression and protein production are ***stimulated*** by IL-1beta or ***TNF-alpha*** through pathways differentially modulated by IL-4 and GM-CSF .	positive	0
3804	10372996	1437;6347	granulocyte/macrophage-colony-stimulating factor;MCP-1	***Modulation*** of IL-8 and ***MCP-1*** production by interleukin-4 ( IL-4 ) , a important mediator in Th2-mediated immunity , and ***granulocyte/macrophage-colony-stimulating factor*** ( GM-CSF ) , one of the cytokines secreted by HRPE has been reported in non-ocular cells .	target	0
3805	10372996	3565;6347	interleukin-4;MCP-1	***Modulation*** of IL-8 and ***MCP-1*** production by ***interleukin-4*** ( IL-4 ) , a important mediator in Th2-mediated immunity , and granulocyte/macrophage-colony-stimulating factor ( GM-CSF ) , one of the cytokines secreted by HRPE has been reported in non-ocular cells .	target	0
3806	10373014	5915;3214	RARbeta;Hoxb4	***RARbeta*** ***mediates*** the response of Hoxd4 and ***Hoxb4*** to exogenous retinoic acid .	target	0
3807	10373014	5915;3233	RARbeta;Hoxd4	***RARbeta*** ***mediates*** the response of ***Hoxd4*** and Hoxb4 to exogenous retinoic acid .	target	0
3808	10373018	3791;7422	FLK-1;vascular endothelial growth factor	These studies indicate that all factors examined , including ***vascular endothelial growth factor*** and its ***receptor*** ***FLK-1*** , Flt-3 ligand and its receptor STK-1 , and stem cell leukemia transcription factor , are expressed by both hematopoietic cells in the cluster and endothelial cells .	parallel	1
3809	10373018	2322;7422	STK-1;vascular endothelial growth factor	These studies indicate that all factors examined , including ***vascular endothelial growth factor*** and its receptor FLK-1 , Flt-3 ligand and its ***receptor*** ***STK-1*** , and stem cell leukemia transcription factor , are expressed by both hematopoietic cells in the cluster and endothelial cells .	parallel	1
3810	10373219	183;3082	angiotensin II;HGF	***HGF*** production is ***downregulated*** by ***angiotensin II*** ( Ang II ) in vitro .	negative	1
3811	10373228	3827;5327	Bradykinin;tPA	***Bradykinin*** ***increased*** ***tPA*** release across the forearm in the absence of systemic effects .	positive	0
3812	10373228	3827;5327	Bradykinin;tPA	These data demonstrate that ***Bradykinin*** ***stimulates*** ***tPA*** release in the human vasculature .	positive	0
3813	10373228	3827;5327	Bradykinin;tPA	The present study tests the hypothesis that ***Bradykinin*** ***increases*** ***tPA*** release in humans through local effects on the vasculature .	positive	0
3814	10373309	6676;4956	Spag4;Odf1	***Spag4*** , a novel sperm protein , ***binds*** outer dense-fiber protein ***Odf1*** and localizes to microtubules of manchette and axoneme .	parallel	1
3815	10373309	6676;4956	Spag4;Odf1	Spag4 mRNA is spermatid specific , and the 49-kDa ***Spag4*** protein ***complexes*** specifically with ***Odf1*** , but not Odf2 , mediated by a leucine zipper .	parallel	1
3816	10373410	5317;1832	plakophilin-1;desmoplakin	In transient expression assays , ***plakophilin-1*** formed ***complexes*** with a ***desmoplakin*** amino-terminal domain and enhanced its recruitment to cell-cell borders ; this recruitment was not dependent on the equimolar expression of desmosomal cadherins .	parallel	1
3817	10373410	1832;5317	desmoplakin;plakophilin-1	In contrast to desmoplakin-plakoglobin interactions , the ***interaction*** between ***desmoplakin*** and ***plakophilin-1*** was not mediated by the armadillo repeat domain of plakophilin-1 but by the non-armadillo head domain , as assessed by yeast two-hybrid and recruitment assays .	parallel	1
3818	10373412	6750;22941	somatostatin;cortactin-binding protein 1	Agonist-dependent ***interaction*** of the rat ***somatostatin*** receptor subtype 2 with ***cortactin-binding protein 1*** .	parallel	1
3819	10373416	10849;916	CAST;CD3epsilon	***CAST*** specifically ***interacts*** in vivo and in vitro with ***CD3epsilon*** but not with CD3zeta or FcRgamma via a unique membrane-proximal region of CD3epsilon .	parallel	1
3820	10373416	10849;2207	CAST;FcRgamma	***CAST*** specifically ***interacts*** in vivo and in vitro with CD3epsilon but not with CD3zeta or ***FcRgamma*** via a unique membrane-proximal region of CD3epsilon .	parallel	1
3821	10373426	718;5141	ASP;PDE4	Phosphodiesterase 3 ( PDE3 ) activity was stimulated by ASP and insulin , whereas ***PDE4*** activity was slightly ***increased*** by ***ASP*** only .	positive	0
3822	10373445	6464;2885	Shc;Grb2	Our results also show that shear stress induced an association of alphavbeta3 and beta1 integrins with Shc , and an attendant ***association*** of ***Shc*** with ***Grb2*** .	parallel	0
3823	10373445	6464;3725	Shc;c-Jun	***Shc-SH2*** , an expression plasmid encoding the SH2 domain of Shc , ***attenuated*** shear stress activation of extracellular signal-regulated kinases and ***c-Jun*** N-terminal kinases , and the gene transcription mediated by the activator protein-1 / 12-O-tetradecanoylphorbol-13-acetate-responsive element complex .	negative	0
3824	10373468	9091;5277	GPI1;PIG-A	In mammalian cells , this reaction is mediated by a ***complex*** of ***PIG-A*** , PIG-H , PIG-C , and ***GPI1*** .	parallel	1
3825	10373468	9091;5283	GPI1;PIG-H	In mammalian cells , this reaction is mediated by a ***complex*** of PIG-A , ***PIG-H*** , PIG-C , and ***GPI1*** .	parallel	1
3826	10373468	5279;9091	PIG-C;GPI1	In mammalian cells , this reaction is mediated by a ***complex*** of PIG-A , PIG-H , ***PIG-C*** , and ***GPI1*** .	parallel	1
3827	10373468	5279;5277	PIG-C;PIG-A	In mammalian cells , this reaction is mediated by a ***complex*** of ***PIG-A*** , PIG-H , ***PIG-C*** , and GPI1 .	parallel	1
3828	10373468	5279;5283	PIG-C;PIG-H	In mammalian cells , this reaction is mediated by a ***complex*** of PIG-A , ***PIG-H*** , ***PIG-C*** , and GPI1 .	parallel	1
3829	10373468	5283;5277	PIG-H;PIG-A	In mammalian cells , this reaction is mediated by a ***complex*** of ***PIG-A*** , ***PIG-H*** , PIG-C , and GPI1 .	parallel	1
3830	10373468	5283;5277	PIG-H;PIG-A	A complex of PIG-A , PIG-H , and PIG-C decreased to a nearly undetectable level , whereas a ***complex*** of ***PIG-A*** and ***PIG-H*** was easily detected .	parallel	1
3831	10373468	5279;5277	PIG-C;PIG-A	A ***complex*** of ***PIG-A*** , PIG-H , and ***PIG-C*** decreased to a nearly undetectable level , whereas a complex of PIG-A and PIG-H was easily detected .	parallel	1
3832	10373468	5283;5279	PIG-H;PIG-C	A ***complex*** of PIG-A , ***PIG-H*** , and ***PIG-C*** decreased to a nearly undetectable level , whereas a complex of PIG-A and PIG-H was easily detected .	parallel	1
3833	10373468	5283;5277	PIG-H;PIG-A	Therefore , GPI1 stabilizes the enzyme by tying up PIG-C with a ***complex*** of ***PIG-A*** and ***PIG-H*** .	parallel	1
3834	10373476	5757;1938	prothymosin alpha;eEF-2	Recently , Vega et al. proposed that exogenous ***prothymosin alpha*** can specifically ***increase*** the phosphorylation of eukaryotic elongation factor 2 ( ***eEF-2*** ) in extracts of NIH3T3 cells ( Vega , F.	positive	0
3835	10373477	5594;2885	ERK;Grb2	Although treatment with the phorbol myristate acetate resulted in ***ERK*** ***activation*** and complete dissociation of the ***Grb2-SOS*** complex , there was no effect on subsequent insulin-stimulated Ras activation .	positive	1
3836	10373483	7124;84959	TNFalpha;p70	***TNFalpha*** ***inhibited*** ***p70*** ( s6k ) activation by glucose-stimulated beta-cells of the islets of Langerhans in a dose - and time-dependent manner , with maximal inhibition observed at approximately 20-50 ng/ml , detected after 24 and 48 h of exposure .	negative	1
3837	10373483	7124;84959	TNFalpha;p70	Exogenous insulin failed to prevent ***TNFalpha-induced*** ***inhibition*** of ***p70*** ( s6k ) , suggesting a defect in the insulin signaling pathway .	negative	1
3838	10373483	7124;84959	TNFalpha;p70	Furthermore , the ability of IL-1 receptor antagonist protein , IRAP , to block ***TNFalpha-induced*** ***inhibition*** of ***p70*** ( s6k ) indicated that activation of intra-islet macrophages and the release of IL-1 that induces inos expression in beta-cells was responsible for the inhibitory effects of TNFalpha .	negative	1
3839	10373483	3553;4843	IL-1;inos	Furthermore , the ability of IL-1 receptor antagonist protein , IRAP , to block TNFalpha-induced inhibition of p70 ( s6k ) indicated that activation of intra-islet macrophages and the release of ***IL-1*** that ***induces*** ***inos*** expression in beta-cells was responsible for the inhibitory effects of TNFalpha .	target	1
3840	10373493	5294;933	PI3K;CD22	This finding suggests that PLCgamma and ***PI3K*** may be ***recruited*** to ***CD22*** either through a direct interaction with Tyr863 or indirectly through an association with one or more intermediate proteins .	target	0
3841	10373501	4790;4792	NF-kappaB;IkappaBalpha	In most cases , constitutive ***NF-kappaB*** DNA binding ***correlated*** with reduced levels of either ***IkappaBalpha*** or IkappaBbeta isoforms .	parallel	0
3842	10373512	7979;675	DSS1;BRCA2	Yeast and mammalian two-hybrid assays showed that ***DSS1*** can ***associate*** with ***BRCA2*** in the region of amino acids 2472 to 2957 in the C terminus of the protein .	parallel	0
3843	10373512	675;7979	BRCA2;DSS1	Furthermore , endogenous ***BRCA2*** could be ***coimmunoprecipitated*** with endogenous ***DSS1*** in MCF7 cells , demonstrating an in vivo association .	parallel	1
3844	10373514	1965;4790	eIF-2alpha;NF-kappaB	The translation initiation factor ***eIF-2alpha*** ( alpha subunit of eukaryotic translation initiation factor 2 ) and IkappaBalpha , the ***inhibitor*** of the transcription factor ***NF-kappaB*** , have been proposed as downstream mediators of PKR effects .	negative	1
3845	10373514	5610;4790	PKR;NF-kappaB	Biochemical analysis and transient assays revealed that ***PKR*** expression by a VV vector ***induced*** ***NF-kappaB*** binding and transactivation .	target	1
3846	10373516	4609;1019	c-Myc;Cdk4	***c-Myc*** ***regulates*** cyclin ***D-Cdk4*** and - Cdk6 activity but affects cell cycle progression at multiple independent points .	target	1
3847	10373517	3667;3643	IRS1;insulin receptor	This inhibition of insulin-stimulated downstream signaling occurred without any significant effect on insulin receptor autophosphorylation or tyrosine phosphorylation of ***insulin receptor*** ***substrate*** 1 ( ***IRS1*** ) .	parallel	1
3848	10373527	1022;902	MO15;cyclin H	This finding provides in vivo support for the previous biochemical observation that ******MO15-cyclin H****** ***complexes*** can be activated either by activating phosphorylation of MO15 or by binding to MAT1 .	parallel	1
3849	10373529	3556;9139	IL-1 receptor accessory protein;p85	We have found that IL-1 stimulates ***interaction*** of the ***IL-1 receptor accessory protein*** with the ***p85*** regulatory subunit of PI3K , leading to the activation of the p110 catalytic subunit .	parallel	1
3850	10373529	3553;3556	IL-1;IL-1 receptor accessory protein	We have found that ***IL-1*** ***stimulates*** interaction of the ***IL-1 receptor accessory protein*** with the p85 regulatory subunit of PI3K , leading to the activation of the p110 catalytic subunit .	positive	0
3851	10373529	3553;4792	IL-1;IkappaBalpha	Specific PI3K inhibitors strongly inhibit both PI3K activation and NF-kappaB-dependent gene expression but have no effect on the ***IL-1-stimulated*** ***degradation*** of ***IkappaBalpha*** , the nuclear translocation of NF-kappaB , or the ability of NF-kappaB to bind to DNA .	negative	1
3852	10373529	3553;4790	IL-1;NF-kappaB	In contrast , PI3K inhibitors block the ***IL-1-stimulated*** ***phosphorylation*** of ***NF-kappaB*** itself , especially the p65/RelA subunit .	target	1
3853	10373529	5290;4790	PI3K;NF-kappaB	Therefore , IL-1 stimulates the ***PI3K-dependent*** ***phosphorylation*** and transactivation of ***NF-kappaB*** , a process quite distinct from the liberation of NF-kappaB from its cytoplasmic inhibitor IkappaB .	target	1
3854	10373529	3553;4790	IL-1;NF-kappaB	Therefore , ***IL-1*** ***stimulates*** the PI3K-dependent phosphorylation and transactivation of ***NF-kappaB*** , a process quite distinct from the liberation of NF-kappaB from its cytoplasmic inhibitor IkappaB .	positive	0
3855	10373531	993;5894	Cdc25A;Raf-1	***Cdc25A*** was found to ***dephosphorylate*** ***Raf-1*** on tyrosines that resulted in a significant decrease in Raf-1 kinase activity .	target	1
3856	10373534	672;1017	BRCA1;CDK2	Furthermore , ***BRCA1*** ***coimmunoprecipitates*** with ***CDK2*** and cyclin A.	parallel	1
3857	10373539	9099;7398	USP-2;USP-1	When cell extracts were used , the EcR-B1-USP-2 heterodimer showed no binding to EcRE1 , and the presence of excess ***USP-2*** ***prevented*** the binding of ***EcR-B1-USP-1*** to this element .	negative	0
3858	10373541	6304;1523	SATB1;CDP	***SATB1*** ***interacted*** with ***CDP*** through its DNA-binding domain , as demonstrated by glutathione S-transferase ( GST ) pull-down assays .	parallel	1
3859	10373541	1523;6304	CDP;SATB1	GST pull-down assays also showed that ***CDP*** ***associated*** with ***SATB1*** through three of its four DNA-binding domains ( CR1 , CR2 , and the homeodomain ) .	parallel	0
3860	10373541	1523;6304	CDP;SATB1	Far-Western blotting detected ***interaction*** of ***SATB1*** and ***CDP*** in several different tissue extracts .	parallel	1
3861	10373541	1523;6304	CDP;SATB1	***Association*** of purified ***SATB1*** and ***CDP*** in vitro resulted in the inability of each protein to bind to DNA in gel retardation assays .	parallel	0
3862	10373544	9328;9330	hTFIIIC63;hTFIIIC102	These include novel ***interactions*** of ***hTFIIIC63*** with ***hTFIIIC102*** , with hTFIIIB90 , and with hRPC62 , in addition to the hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel the previously described interactions in yeast .	parallel	1
3863	10373548	3558;6777	IL-2;STAT5b	Additionally , in lymphocytes expressing SOCS-3 but not CIS , ***IL-2-induced*** tyrosine ***phosphorylation*** of ***STAT5b*** was markedly reduced , while there was only a weak effect on IL-3-mediated STAT5b tyrosine phosphorylation .	target	1
3864	10373548	3558;9021	IL-2;SOCS-3	The findings suggest that when ***SOCS-3*** is rapidly ***induced*** by ***IL-2*** in T cells , it acts to inhibit IL-2 responses in a classical negative feedback loop .	target	1
3865	10373548	9021;3716	SOCS-3;Jak1	In these experiments , ***SOCS-3*** ***associated*** with ***Jak1*** and inhibited Jak1 phosphorylation , and this inhibition was markedly enhanced by the presence of IL-2 receptor beta chain ( IL-2Rbeta ) .	parallel	0
3866	10373551	695;2969	Btk;TFII-I	Thus , mutations impairing the physical and/or functional ***association*** between ***TFII-I*** and ***Btk*** may result in diminished TFII-I-dependent transcription and contribute to defective B-cell development and/or function .	parallel	0
3867	10373551	695;2969	Bruton's tyrosine kinase;TFII-I	***Regulation*** of nuclear localization and transcriptional activity of ***TFII-I*** by ***Bruton's tyrosine kinase*** .	target	1
3868	10373551	2969;695	TFII-I;Btk	***TFII-I*** ***associates*** constitutively in vivo with wild-type Btk and kinase-inactive ***Btk*** but not xid Btk .	parallel	0
3869	10373555	5170;2185	3-phosphoinositide-dependent protein kinase 1;protein kinase B	Domain swapping used to investigate the mechanism of ***protein kinase B*** ***regulation*** by ***3-phosphoinositide-dependent protein kinase 1*** and Ser473 kinase .	target	1
3870	10373559	6772;6773	Stat1;Stat2	In response to IFN-alpha , ***Stat1*** ***binds*** to ***Stat2*** in a heterodimer that recruits p48 , an IRF family member , to activate transcription .	parallel	1
3871	10373560	891;983	cyclin B1;Cdc2	Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of ******Cdc2-cyclin B1****** ***complexes*** .	parallel	1
3872	10373560	9088;983	Myt1;Cdc2	The ***Myt1*** protein kinase functions to negatively ***regulate*** ***Cdc2-cyclin*** B complexes by phosphorylating Cdc2 on threonine 14 and tyrosine 15 .	negative	1
3873	10373560	983;891	Cdc2;cyclin B1	Throughout interphase , human Myt1 localizes to the endoplasmic reticulum and Golgi complex , whereas ******Cdc2-cyclin B1****** ***complexes*** shuttle between the nucleus and the cytoplasm .	parallel	1
3874	10373560	983;891	Cdc2;cyclin B1	Myt1 mutants lacking this domain no longer bound cyclin B1 and did not efficiently phosphorylate ******Cdc2-cyclin B1****** ***complexes*** in vitro .	parallel	1
3875	10373560	9088;983	Myt1;Cdc2	These results suggest that the docking of Cdc2-cyclin B1 complexes to the COOH terminus of Myt1 facilitates the ***phosphorylation*** of ***Cdc2*** by ***Myt1*** and that overproduction of Myt1 perturbs cell cycle progression by sequestering Cdc2-cyclin B1 complexes in the cytoplasm .	target	1
3876	10373560	983;891	Cdc2;cyclin B1	These results suggest that the docking of Cdc2-cyclin B1 complexes to the COOH terminus of Myt1 facilitates the phosphorylation of Cdc2 by Myt1 and that overproduction of Myt1 perturbs cell cycle progression by sequestering ******Cdc2-cyclin B1****** ***complexes*** in the cytoplasm .	parallel	1
3877	10373563	4214;367	MEKK1;androgen receptor	***MEKK1*** also ***stimulates*** the transcriptional activity of the ***androgen receptor*** in the presence or absence of ligand , whereas a dominant negative mutant of MEKK1 impairs activation of the androgen receptor by androgen .	positive	0
3878	10373563	4214;367	MEKK1;androgen receptor	MEKK1 also stimulates the transcriptional activity of the androgen receptor in the presence or absence of ligand , whereas a dominant negative mutant of ***MEKK1*** ***impairs*** activation of the ***androgen receptor*** by androgen .	positive	0
3879	10373567	1600;351	Dab1;APP	***Dab1*** ***associates*** with the ***APP*** cytoplasmic domain in transfected cells and is coexpressed with APP in hippocampal neurons .	parallel	0
3880	10373581	1432;4205	p38 MAP kinase;MEF2A	Subsequent phosphopeptide mapping and phosphoamino acid analysis indicated the appearance of several phoshopeptides due to ***p38 MAP kinase*** ***activation*** of ***MEF2A*** which were due to phosphorylation on serine and threonine residues .	positive	1
3881	10373589	1387;6778	CBP;Stat6	***p300/CBP*** is required for transcriptional induction by interleukin-4 and ***interacts*** with ***Stat6*** .	parallel	1
3882	10373589	2033;6778	p300;Stat6	***p300/CBP*** is required for transcriptional induction by interleukin-4 and ***interacts*** with ***Stat6*** .	parallel	1
3883	10373589	3565;6778	interleukin-4;Stat6	***interleukin-4*** ( IL-4 ) ***induces*** tyrosine phosphorylation of the latent transcription factor ***Stat6*** , which mediates the transcriptional responses of IL-4 .	target	1
3884	10373589	6778;3565	Stat6;IL-4	interleukin-4 ( IL-4 ) induces tyrosine phosphorylation of the latent transcription factor ***Stat6*** , which ***mediates*** the transcriptional responses of ***IL-4*** .	target	0
3885	10373597	3516;3569	CBF1;IL-6	By transfection analyses performed in HeLa cells , we demonstrate that overexpressed ***CBF1*** acts as a negative ***regulator*** of ***IL-6*** gene transcription and is unable to elicit Notch-dependent activation of this gene .	negative	1
3886	10373597	3516;3569	CBF1;IL-6	This finding suggests that ***CBF1*** may ***influence*** ***IL-6*** gene transcription by determining a specific conformation of the promoter region .	target	0
3887	10373662	7157;7422	p53;VEGF	The ***association*** between MVD , ***VEGF*** expression , ***p53*** mutations and preinvasive lesions of the bronchial tree suggests that neoangiogenesis is early in non-small cell lung cancer ( NSCLC ) development and that p53 may have an important role in promoting angiogenesis in this human model of carcinogenesis .	parallel	0
3888	10374073	925;6647	CD8;homodimer	The ratio of T cell subsets expressing CD8 alpha alpha ******homodimer/CD8****** alpha beta ***heterodimer*** was found to be higher in the dark period than that in the light period .	parallel	1
3889	10374333	7157;4193	p53;MDM2	There was a striking ***association*** between ***MDM2*** and ***p53*** overexpressions .	parallel	0
3890	10374718	133;5594	adrenomedullin;ERK2	Associated with the changes in proliferation and apoptosis , ***adrenomedullin*** ***decreased*** ***ERK2*** activity , and increased JNK1 and P38 MAPK activities .	negative	0
3891	10374718	133;5599	adrenomedullin;JNK1	Associated with the changes in proliferation and apoptosis , ***adrenomedullin*** decreased ERK2 activity , and ***increased*** ***JNK1*** and P38 MAPK activities .	positive	0
3892	10374718	133;5594	adrenomedullin;P38	Associated with the changes in proliferation and apoptosis , ***adrenomedullin*** decreased ERK2 activity , and ***increased*** JNK1 and ***P38*** MAPK activities .	positive	0
3893	10374772	2208;3497	CD23;IgE	***CD23*** functions as the ***receptor*** for ***IgE*** and also appears to play a role in controlling the growth and proliferation of lymphocytes .	parallel	1
3894	10374812	3458;3586	interferon-gamma;IL-10	The T helper 1-type cytokine ***interferon-gamma*** ( IFN-gamma ) induced TNF transcripts , but not TNF secretion , and ***suppressed*** LPS-induced ***IL-10*** mRNA and secretion by microglia .	negative	1
3895	10374817	43;351	AChE;Abeta	Our results suggest that Neuro 2a cells are less susceptible to exposure to ******AChE-Abeta****** ***complexes*** , Abeta25-35 fragment , glutamate and H2O2 than PC12 cells , due to higher intracellular levels of antioxidant defense factors .	parallel	1
3896	10374837	6670;4953	Sp3;ODC	We have shown that the transcription factor Sp1 is one of the regulators of ODC expression and that ***Sp3*** ***antagonizes*** this Sp1-mediated activation of ***ODC*** expression .	negative	1
3897	10374846	356;355	FasL;Fas	Co-treatment did not significantly alter Bcl2 , Bcl-xL , Bax or Fas receptor ( FasR ) , but modestly increased ***Fas*** ***ligand*** ( ***FasL*** ) protein .	parallel	1
3898	10374859	947;1791	CD34;TdT	***CD34*** positivity was highly ***correlated*** with ***TdT*** expression ( P < 0.0001 ) .	parallel	0
3899	10374878	6774;581	Stat3;Bax	Inhibition of constitutively activated ***Stat3*** ***correlates*** with altered ***Bcl-2/Bax*** expression and induction of apoptosis in mycosis fungoides tumor cells .	parallel	0
3900	10374878	6774;596	Stat3;Bcl-2	Inhibition of constitutively activated ***Stat3*** ***correlates*** with altered ***Bcl-2/Bax*** expression and induction of apoptosis in mycosis fungoides tumor cells .	parallel	0
3901	10374879	836;5371	caspase-3;PML	In acute promyelocytic leukemia NB4 cells , the synthetic retinoid CD437 induces contemporaneously apoptosis , a ***caspase-3-mediated*** ***degradation*** of ***PML/RARalpha*** protein and the PML retargeting on PML-nuclear bodies .	negative	1
3902	10374879	836;5914	caspase-3;RARalpha	In acute promyelocytic leukemia NB4 cells , the synthetic retinoid CD437 induces contemporaneously apoptosis , a ***caspase-3-mediated*** ***degradation*** of ***PML/RARalpha*** protein and the PML retargeting on PML-nuclear bodies .	negative	1
3903	10374881	3717;10603	Janus kinase-2;APS	Here , we report that ***APS*** was tyrosine ***phosphorylated*** by ***Janus kinase-2*** ( JAK2 ) at its C-terminal tyrosine residue and interacted with c-Cbl .	target	1
3904	10374908	2641;5443	glucagon;ACTH	In contrast , ***glucagon*** and GLP-1 partially ( 40 % ) ***inhibited*** ***ACTH*** ( 10 ( -9 ) M ) - enhanced corticosterone secretion of inner cells , maximal effective concentration being 10 ( -7 ) M.	negative	1
3905	10374915	6750;5443	somatostatin;beta-endorphin	Our results showed that ***somatostatin*** treatment significantly ***increased*** ***beta-endorphin*** levels in the blood and lymphocytes from popliteal lymph nodes .	positive	0
3906	10375014	2353;3484	c-fos;IGFBP-1	Co-expression of ***c-fos*** or c-jun in rat hepatocytes , individually or together , ***suppresses*** ***IGFBP-1*** promoter activity by approximately 60 % .	negative	1
3907	10375014	3725;3484	c-jun;IGFBP-1	Co-expression of c-fos or ***c-jun*** in rat hepatocytes , individually or together , ***suppresses*** ***IGFBP-1*** promoter activity by approximately 60 % .	negative	1
3908	10375033	2494;1588	FTZ-F1;aromatase	Medaka ( Oryzias latipes ) ***FTZ-F1*** potentially ***regulates*** the transcription of P-450 ***aromatase*** in ovarian follicles : cDNA cloning and functional characterization .	target	1
3909	10375532	6500;8454	Skp1;Cul-1	Skp2-dependent ***associations*** between ***Skp1*** or ***Cul-1*** and the p27 phosphopeptide were also detected .	parallel	0
3910	10375961	3553;5443	IL-1 beta;ACTH	Intravenous administrations of ***IL-1 beta*** ***increased*** AVP , atrial natriuretic hormone ( ANH ) and ***ACTH*** .	positive	0
3911	10375961	3553;551	IL-1 beta;AVP	Intravenous administrations of ***IL-1 beta*** ***increased*** ***AVP*** , atrial natriuretic hormone ( ANH ) and ACTH .	positive	0
3912	10376217	834;3606	ICE;interleukin-18	caspase-1 , or interleukin-1 beta converting enzyme ( ***ICE*** ) , ***promotes*** maturation of interleukin-1 beta ( IL-1 beta ) and ***interleukin-18*** ( IL-18 ) by proteolytic cleavage of precursor forms to generate biologically active peptides .	positive	0
3913	10376217	834;3553	ICE;interleukin-1 beta	caspase-1 , or interleukin-1 beta converting enzyme ( ***ICE*** ) , ***promotes*** maturation of ***interleukin-1 beta*** ( IL-1 beta ) and interleukin-18 ( IL-18 ) by proteolytic cleavage of precursor forms to generate biologically active peptides .	positive	0
3914	10376217	3553;3606	interleukin-1 beta;interleukin-18	caspase-1 , or ***interleukin-1 beta*** converting enzyme ( ICE ) , ***promotes*** maturation of interleukin-1 beta ( IL-1 beta ) and ***interleukin-18*** ( IL-18 ) by proteolytic cleavage of precursor forms to generate biologically active peptides .	positive	0
3915	10376266	1392;5443	corticotropin-releasing factor;ACTH	The addition of ***corticotropin-releasing factor*** to primary trophoblast cell cultures ***stimulates*** ***ACTH*** secretion in a dose-dependent manner , and its action is mediated by cyclic adenosine monophosphate as second messenger .	positive	0
3916	10376522	3084;2064	NDF;ErbB2	Neu differentiation factor ( ***NDF*** ) / heregulin ***activates*** ***ErbB2*** via heterodimerization with the NDF receptors ErbB3 and ErbB4 .	positive	1
3917	10376522	2064;2065	ErbB2;ErbB3	G1 progression was associated with ***ErbB2*** ***transactivation*** of ***ErbB3*** and subsequent stimulation of the phosphatidylinositol 3-kinase ( PI3K ) pathway whereas apoptosis was dependent on p38 MAPK .	positive	1
3918	10376524	4342;3308	c-Mos;Hsp70	Based on our identification of ******c-Mos-Hsp70****** ***interaction*** , one of the roles of ATP may be to assist the regulation of c-Mos via ATP involvement in the protein-folding function of Hsp70 and possibly other molecular chaperones .	parallel	1
3919	10376524	4342;3308	c-Mos;Hsp70	We also detected by coimmunoprecipitation a physical ***association*** between endogenous ***c-Mos*** and ***Hsp70*** in Xenopus eggs .	parallel	0
3920	10376524	4342;3308	c-Mos;Hsp70	We provide evidence that mouse ***c-Mos*** ***binds*** to ***Hsp70*** , a molecular chaperone .	parallel	1
3921	10376527	11016;5601	ATFa;JNK2	Role of the ******ATFa/JNK2****** ***complex*** in Jun activation .	parallel	1
3922	10376527	11016;5601	ATFa;JNK2	We also show that the N-terminal domain of ***ATFa*** which stably ***binds*** the Jun N-terminal kinase-2 ( ***JNK2*** ) ( Bocco et al. , 1996 ) , is not a substrate for this kinase in vivo but , instead , serves as a JNK2-docking site for ATFa-associated partners like JunD , allowing them to be phosphorylated by the bound kinase .	parallel	1
3923	10376594	317;112752	CED-4;CED-3	Furthermore , analysis of homologues from Caenorhabditis elegans indicates that ***recruitment*** of ***CED-3*** by ***CED-4*** is probably mediated by the same set of conserved structural motifs , with a corresponding change in the specificity-determining residues .	target	0
3924	10376604	9044;6908	Mot1;TBP	Using mutant yeast strains , we show that ***Mot1*** ***prevents*** the binding of ***TBP*** to inactive promoters and that activator-mediated stimulation of TBP binding requires additional GTFs , including TFIIB and Srb4 .	negative	0
3925	10376794	2950;2944	GSTP1;GSTM1	The potential ***interaction*** of ***GSTM1*** and ***GSTP1*** genotypes in pulmonary carcinogenesis was assessed in 382 male Japanese lung cancer patients ( 127 squamous cell carcinoma , 78 small cell carcinoma , 177 adenocarcinoma ) and 257 controls .	parallel	1
3926	10376794	2950;2944	GSTP1;GSTM1	The estimated relative risk of the GSTM1 null genotype for lung cancer was 2.58 ( 95 % CI = 1.26-5 .30 ) in smokers with the GSTP1 mutant allele while it was 1.17 ( 95 % CI = 0.77-1 .79 ) in those without , suggesting that mutated ***GSTM1*** and ***GSTP1*** genotypes ***interact*** to potentiate the risk of lung cancers in Japanese smokers .	parallel	1
3927	10376804	3576;5706	NaF;p44	PD98059 suppressed the IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate ( TPA ) , a protein kinase C ( PKC ) activator , or NaF , an activator of heterotrimeric GTP-binding protein , as well as the ***p42/p44*** MAP kinase ***activation*** by TPA or ***NaF*** .	positive	1
3928	10376805	3562;6777	IL-3;STAT5	Here we show that , in IFN-alpha-responsive Ba/F3 cells , this cytokine stimulates the DNA-binding of STAT5A and B but that ***IL-3*** is a much more potent ***activator*** of both ***STAT5*** isoforms .	positive	1
3929	10376805	3562;5292	IL-3;pim-1	Northern blots revealed that ***IL-3*** strongly ***induced*** the expression of two STAT5-regulated genes , ***pim-1*** and oncostatin-M , whereas IFN-alpha had a weak stimulatory effect on pim-1 expression only .	target	1
3930	10376811	5970;3725	p65;AP-1	Evidence that PDTC induced AP-1 DNA binding and AP-1 reporter gene activity , raised the hypothesis that the effect of PDTC was mediated by an ***interaction*** between the ***AP-1*** pathway and ***p65*** ( RelA ) .	parallel	1
3931	10376933	7040;3576	TGF beta;IL-8	In contrast , transforming growth factor beta ( ***TGF beta*** ) , appeared to down ***modulate*** tat-induced ***IL-8*** production .	target	0
3932	10376964	1026;1019	p21;cdk4	Co-immunoprecipitation with anti-cdk4 antibody showed that induced ***p21*** ***associates*** with ***cdk4*** and that its kinase activity is reduced by TGF-beta , which kinetically correlates closely with G1 arrest following TGF-beta treatment of both cell lines .	parallel	0
3933	10376969	1029;595	p16INK4a;cyclin D1	Our findings support the hypothesis that ***cyclin D1*** and ***p16INK4a*** can ***cooperate*** to dysregulate the cell cycle , but that loss of Rb protein abolishes the G1 checkpoint completely , removing any selective advantage for cells that alter additional cell cycle proteins .	parallel	0
3934	10376986	595;7157	Cyclin D1;p53	We found that : ( 1 ) Cyclin D1 was expressed in 13 ( 11.7 % ) of 111 NSCLCs ; ( 2 ) the Cyclin D1 gene was neither significantly amplified nor rearranged ; ( 3 ) ***Cyclin D1*** expression significantly ***correlated*** with altered ***p53*** protein expression ( P = 0.04 ) , whereas it did not correlate with p16 and RB protein status ; ( 4 ) proliferative activity tended to be higher in Cyclin D1-positive ( + ) tumours than in Cyclin D1-negative ( - ) tumours , although this difference was not statistically significant ( P = 0.08 ) ; and ( 5 ) patients with Cyclin D1 + tumours survived longer than patients with Cyclin D1 - tumours ( 5-year survival rates , 89 % and 64 % respectively , by the Kaplan-Meier method ; P = 0.045 by the log-rank test ) , and Cyclin D1 expression tended to be a favourable prognostic factor ( P = 0.08 in univariate analysis ) .	parallel	0
3935	10377033	356;355	FasL;Fas	The Fas system has been implicated as a possible key regulator of apoptosis in various cells : binding of ***Fas*** ***ligand*** ( ***FasL*** ) , a type II transmembrane protein , to Fas , a type I transmembrane receptor protein , triggers apoptosis in cells expressing Fas .	parallel	1
3936	10377033	356;355	FasL;Fas	The Fas system has been implicated as a possible key regulator of apoptosis in various cells : ***binding*** of Fas ligand ( ***FasL*** ) , a type II transmembrane protein , to ***Fas*** , a type I transmembrane receptor protein , triggers apoptosis in cells expressing Fas .	parallel	1
3937	10377139	958;959	CD40;CD40L	These results indicate that ******CD40-CD40L****** ***signaling*** may be an important step in host immune response against M. avium infection .	parallel	0
3938	10377182	3565;3557	IL-4;IL-1Ra	In M. tuberculosis-stimulated peripheral blood mononuclear cells , the addition of ***IL-4*** ***increased*** ***IL-1Ra*** secretion , whereas interferon gamma increased and IL-10 decreased IL-1beta production , indicative of a differential influence on the IL-1Ra/IL-1beta ratio by cytokines .	positive	0
3939	10377182	3458;3553	interferon gamma;IL-1beta	In M. tuberculosis-stimulated peripheral blood mononuclear cells , the addition of IL-4 increased IL-1Ra secretion , whereas ***interferon gamma*** ***increased*** and IL-10 decreased ***IL-1beta*** production , indicative of a differential influence on the IL-1Ra/IL-1beta ratio by cytokines .	positive	0
3940	10377183	958;959	CD40;CD40 ligand	Induction of cytotoxic T lymphocyte ( CTL ) responses against minor histocompatibility antigens is dependent upon the presence of T cell help and requires the ***interaction*** of ***CD40*** on dendritic cells ( DCs ) with ***CD40 ligand*** on activated T helper cells ( Th ) .	parallel	1
3941	10377195	6348;1437	MIP-1alpha;CSF	Moreover , ***MIP-1alpha*** did not mobilize MPCs to the blood or ***synergize*** with ***G-CSF*** in this effect in CCR1 ( - / - ) mice .	parallel	0
3942	10377223	1432;7124	p38 MAP kinase;TNF-alpha	This work led to identification of 48 , a potent ( ***p38 MAP kinase*** inhibition IC50 0.24 nM ) and selective p38 MAP kinase inhibitor which ***inhibits*** lipopolysaccharide-stimulated release of ***TNF-alpha*** from human blood with an IC50 2.2 nM , shows good oral bioavailability in rat and rhesus monkey , and demonstrates significant improvement in measures of disease progression in a rat adjuvant-induced arthritis model .	negative	1
3943	10377245	3075;7124	Factor H;TNF-alpha	Pretreatment of ***Factor H*** with sialidase ***reduced*** both the binding of L-selectin to Factor H and the Factor H-induced L-selectin-mediated ***TNF-alpha*** secretion by leukocytes .	negative	1
3944	10377265	183;4690	Angiotensin II;Nck	***Angiotensin II*** ***stimulates*** serine phosphorylation of the adaptor protein ***Nck*** : physical association with the serine/threonine kinases Pak1 and casein kinase I.	positive	0
3945	10377265	183;4690	Angiotensin II;Nck	We report here that ***Angiotensin II*** , working through the AT1 receptor subtype , ***stimulates*** the phosphorylation of ***Nck*** in rat aortic smooth muscle cells .	positive	0
3946	10377335	5008;7124	OSM;TNF-alpha	Oncostatin M ( ***OSM*** ) induced IL-6 alone and ***synergized*** with ***TNF-alpha*** for enhanced expression .	parallel	0
3947	10377335	5008;3569	OSM;IL-6	Oncostatin M ( ***OSM*** ) ***induced*** ***IL-6*** alone and synergized with TNF-alpha for enhanced expression .	target	1
3948	10377336	2247;4137	fibroblast growth factor-2;tau	Dynamic regulation of expression and ***phosphorylation*** of ***tau*** by ***fibroblast growth factor-2*** in neural progenitor cells from adult rat hippocampus .	target	1
3949	10377336	2247;4137	fibroblast growth factor-2;tau	We have found that neural progenitor cells from adult rat hippocampus express adult isoforms of tau and that the expression and the phosphorylation of ***tau*** are ***regulated*** by ***fibroblast growth factor-2*** ( FGF-2 ) .	target	1
3950	10377346	5663;207	presenilin-1;Akt	Mutant ***presenilin-1*** induces apoptosis and ***downregulates*** ***Akt/PKB*** .	negative	1
3951	10377349	4803;627	NGF;BDNF	In this report , we provide evidence that NGF and BDNF have functionally antagonistic actions on sympathetic neuron growth and target innervation , with ***NGF*** acting via TrkA to ***promote*** growth and ***BDNF*** via p75NTR to inhibit growth .	positive	0
3952	10377389	81570;3308	ClpB;Hsp70	Functional chaperone ***cooperation*** between ***Hsp70*** ( DnaK ) and Hsp104 ( ***ClpB*** ) was demonstrated in vitro .	parallel	0
3953	10377395	3553;5743	IL-1beta;cyclooxygenase-2	A549 cells have been used as a model system to study ***cyclooxygenase-2*** ***induction*** by ***IL-1beta*** .	target	1
3954	10377409	7430;54776	Ezrin;p85	While investigating the mechanism responsible for this apoptosis , we found that ***Ezrin*** ***interacts*** with ***p85*** , the regulatory subunit of phosphatidylinositol 3-kinase ( PI 3-kinase ) .	parallel	1
3955	10377410	991;6790	Cdc20;aurora2	***Cdc20*** ***associates*** with the kinase ***aurora2/Aik*** .	parallel	0
3956	10377410	991;6790	Cdc20;aurora2	In HeLa cells , ***Cdc20*** is ***associated*** with the kinase ***aurora2/Aik*** .	parallel	0
3957	10377410	991;6790	Cdc20;aurora2	The demonstration that ***Cdc20*** is ***associated*** with ***aurora2/Aik*** suggests that some function of Cdc20 is carried out or regulated through its association with aurora2/Aik .	parallel	0
3958	10377422	10111;4361	Rad50;Mre11	The ******Mre11/Rad50****** protein ***complex*** functions in diverse aspects of the cellular response to double-strand breaks ( DSBs ) , including the detection of DNA damage , the activation of cell cycle checkpoints , and DSB repair .	parallel	1
3959	10377422	10111;4361	Rad50;Mre11	We established mRad50 mutant mice to examine the role of the mammalian ******Mre11/Rad50****** protein ***complex*** in the DNA damage response .	parallel	1
3960	10377422	10111;4361	Rad50;Mre11	However , the null mrad50 mutation is lethal in cultured embryonic stem cells and in early developing embryos , indicating that the mammalian ******Mre11/Rad50****** protein ***complex*** mediates functions in normally growing cells that are essential for viability .	parallel	1
3961	10377438	7329;2120	UBC9;TEL	Based on our data , we conclude that ***UBC9*** physically ***interacts*** with ***TEL*** through the HLH domain and that the interaction leads to modulation of the transcription activity of TEL .	parallel	1
3962	10377438	7329;2120	UBC9;TEL	We show that a protein , ***UBC9*** , ***interacts*** specifically with ***TEL*** in vitro and in vivo .	parallel	1
3963	10377438	2120;7329	TEL;UBC9	These enzymes usually are involved in proteosome-mediated degradation ; however , our data suggest that ***interaction*** of ***TEL*** with ***UBC9*** does not lead to TEL degradation .	parallel	1
3964	10377438	7329;2120	UBC9;TEL	Our studies show that ***UBC9*** ***binds*** to ***TEL*** exclusively through the HLH domain of TEL .	parallel	1
3965	10377443	920;1234	CD4;CCR5	Constitutive cell surface ***association*** between ***CD4*** and ***CCR5*** .	parallel	0
3966	10377443	920;1234	CD4;CCR5	Here , we provide evidence that ***CD4*** is specifically ***associated*** with ***CCR5*** in the absence of gp120 or any other receptor-specific ligand .	parallel	0
3967	10377443	920;1234	CD4;CCR5	The amount of ***CD4*** ***coimmunoprecipitated*** with ***CCR5*** was significantly higher than that with the other major HIV coreceptor , CXCR4 , and in contrast to CXCR4 the CD4-CCR5 coimmunoprecipitation was not significantly increased by gp120 .	parallel	1
3968	10377443	920;1234	CD4;CCR5	The ******CD4-CCR5****** ***interaction*** probably takes place via the second extracellular loop of CCR5 and the first two domains of CD4 .	parallel	1
3969	10377443	920;1234	CD4;CCR5	These findings suggest a possible pathway of HIV-1 evolution and development of immunopathogenicity , a potential new target for antiretroviral drugs and a tool for development of vaccines based on ******Env-CD4-CCR5****** ***complexes*** .	parallel	1
3970	10377443	30816;1234	Env;CCR5	These findings suggest a possible pathway of HIV-1 evolution and development of immunopathogenicity , a potential new target for antiretroviral drugs and a tool for development of vaccines based on ******Env-CD4-CCR5****** ***complexes*** .	parallel	1
3971	10377443	30816;920	Env;CD4	These findings suggest a possible pathway of HIV-1 evolution and development of immunopathogenicity , a potential new target for antiretroviral drugs and a tool for development of vaccines based on ******Env-CD4-CCR5****** ***complexes*** .	parallel	1
3972	10377452	351;7157	APP;p53	Wild-type ***APP*** also strongly ***inhibited*** ***p53*** DNA-binding activity and p53-mediated gene transactivation , whereas FAD-mutant APP did not .	negative	1
3973	10377478	3659;3456	IRF1;IFNbeta	***IRF1*** ***enhances*** the synthesis of ***IFNbeta*** but other pathways may be involved as well .	positive	0
3974	10377880	959;958	CD154;CD40	The ***interaction*** between B-cell molecule ***CD40*** and T-helper surface molecule ***CD154*** is the key event of B-cell (and other antigen-presenting cell) activation .	parallel	1
3975	10377945	10111;4361	hRad50;hMre11	This protein is a component of the ******hMre11/hRad50****** protein ***complex*** , suggesting a defect in DNA double-strand break ( DSB ) repair and/or cell cycle checkpoint function in NBS cells .	parallel	1
3976	10378690	4609;1017	c-Myc;cyclin-dependent kinase 2	Recent work suggests that ***c-Myc*** may ***stimulate*** the activity of cyclin ***E/cyclin-dependent kinase 2*** ( Cdk2 ) complexes and antagonize the action of the Cdk inhibitor p27KIP1 .	positive	0
3977	10378690	4609;1027	c-Myc;p27KIP1	Recent work suggests that ***c-Myc*** may stimulate the activity of cyclin E/cyclin-dependent kinase 2 ( Cdk2 ) complexes and ***antagonize*** the action of the Cdk inhibitor ***p27KIP1*** .	negative	1
3978	10378709	3565;2208	IL-4;CD23	Twelve patients had detectable levels of IL-4 in plasma and 10 in SF ( nine patients in both samples ) ; the absence of ***IL-4*** was ***related*** to a higher expression of ***CD23*** on CD5 + B cells and with higher levels of sCD23 .	parallel	0
3979	10378896	6464;2885	Shc;Grb2	Among upstream signaling molecules of ERK , ***Shc*** was constitutively ***associated*** with ***Grb2*** and was not tyrosine-phosphorylated by GM-CSF and FMLP , and Sos1 and c-Raf-1 were not phosphorylated by GM-CSF , IL-3 , TNF , and FMLP in monocytes , whereas all these signaling molecules were affected and/or utilized by GM-CSF in MO7e cells .	parallel	0
3980	10378898	4254;3815	SCF;c-Kit	******SCF/c-Kit****** ***interaction*** is one factor required for their maintenance , but involvement of other factor ( s ) in the conditioned medium of TBR59 stromal cells was suggested .	parallel	1
3981	10379702	1828;1830	Dsg1;Dsg3	In herpetiform pemphigus ( HP ) most sera recognize ***Dsg1*** and the rest of them ***recognize*** ***Dsg3*** , indicating that HP is a clinical variant of PF or PV .	target	1
3982	10379742	7157;581	p53;Bax	***p53*** mutations in bladder tumors ***inactivate*** the transactivation of the p21 and ***Bax*** genes , and have a predictive value for the clinical outcome after bacillus Calmette-Guerin therapy .	positive	1
3983	10379742	7157;1026	p53;p21	***p53*** mutations in bladder tumors ***inactivate*** the transactivation of the ***p21*** and Bax genes , and have a predictive value for the clinical outcome after bacillus Calmette-Guerin therapy .	positive	1
3984	10379742	7157;581	p53;Bax	CONCLUSIONS : The ***p53*** mutations , using functional assay in yeast , ***inactivate*** the transcription of p21 and ***Bax*** genes , and based on these preliminary results could have a useful predictive value for BCG therapy response in bladder cancer .	positive	1
3985	10379742	7157;1026	p53;p21	CONCLUSIONS : The ***p53*** mutations , using functional assay in yeast , ***inactivate*** the transcription of ***p21*** and Bax genes , and based on these preliminary results could have a useful predictive value for BCG therapy response in bladder cancer .	positive	1
3986	10379900	2661;3037	GDF-9;hyaluronan synthase 2	We find that recombinant ***GDF-9*** ***induces*** ***hyaluronan synthase 2*** ( HAS2 ) , cyclooxygenase 2 ( COX-2 ) , and steroidogenic acute regulator protein ( StAR ) mRNA synthesis but suppresses urokinase plasminogen activator ( uPA ) and LHR mRNA synthesis .	target	1
3987	10379900	2661;960	GDF-9;LHR	We find that recombinant ***GDF-9*** induces hyaluronan synthase 2 ( HAS2 ) , cyclooxygenase 2 ( COX-2 ) , and steroidogenic acute regulator protein ( StAR ) mRNA synthesis but ***suppresses*** urokinase plasminogen activator ( uPA ) and ***LHR*** mRNA synthesis .	negative	1
3988	10379900	2661;5328	GDF-9;uPA	We find that recombinant ***GDF-9*** induces hyaluronan synthase 2 ( HAS2 ) , cyclooxygenase 2 ( COX-2 ) , and steroidogenic acute regulator protein ( StAR ) mRNA synthesis but ***suppresses*** urokinase plasminogen activator ( ***uPA*** ) and LHR mRNA synthesis .	negative	1
3989	10379911	3574;596	IL-7;Bcl-2	This protection is partly mediated by ***IL-7*** ***induction*** of ***Bcl-2*** , however other IL-7-induced events are probably also involved in the trophic response .	target	1
3990	10380079	8829;10371	neuropilin-1;collapsin-1	These results together indicate that ***neuropilin-1*** ***mediates*** ***collapsin-1*** action on axoplasmic transport .	target	0
3991	10380079	10371;8829	collapsin-1;neuropilin-1	To visualize ***collapsin-1*** ***binding*** to endogenous ***neuropilin-1*** , we used a truncated collapsin-1-alkaline phosphatase fusion protein ( CAP-4 ) .	parallel	1
3992	10380878	274;4609	Bin1;Myc	***Bin1*** functionally ***interacts*** with ***Myc*** and inhibits cell proliferation via multiple mechanisms .	parallel	1
3993	10380878	4609;274	Myc;Bin1	These findings supported functional ***interaction*** between ***Myc*** and ***Bin1*** in cells and indicated that Bin1 could inhibit malignant cell growth through multiple mechanisms .	parallel	1
3994	10380881	7039;1956	TGFalpha;EGFR	ErbB2 transgene induction was accompanied by increased expression of ***TGFalpha*** , a ***ligand*** of epidermal growth factor receptor ( ***EGFR*** ) , and to a lesser extent , EGFR , further enhancing RTK signal transduction .	parallel	1
3995	10380882	7157;30008	p53;MBP1	Specific ***interaction*** between ***MBP1*** and mutant ***p53*** was illustrated by both two-hybrid analysis in yeast and co-immunoprecipitation in mammalian cells .	parallel	1
3996	10380884	1432;3725	p38 MAP kinase;AP-1	Inhibition of ***p38 MAP kinase*** ***increases*** okadaic acid mediated ***AP-1*** expression and DNA binding but has no effect on TRE dependent transcription .	negative	0
3997	10380904	3586;4790	IL-10;NF-kappaB	Anti-inflammatory cytokines , ***IL-10*** , and transforming growth factor ( TGF ) - beta sequentially ***inhibited*** LPS - and cytokine-induced microglial cell ***NF-kappaB*** activation , RANTES mRNA expression , and protein release .	negative	1
3998	10380912	3385;3689	ICAM-3;LFA-1	***ICAM-3*** ***binds*** to ***LFA-1*** on antigen-presenting cells ( APC ) stabilizing the T cell-APC interaction , facilitating signaling through the CD3/TCR complex .	parallel	1
3999	10380930	965;914	CD58;CD2	***Interaction*** between ***CD2*** and its counterreceptor , ***CD58*** ( LFA-3 ) , on opposing cells optimizes immune recognition , facilitating contacts between helper T lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells .	parallel	1
4000	10380930	914;965	CD2;CD58	Here , we report the crystal structure of the heterophilic adhesion ***complex*** between the amino-terminal domains of human ***CD2*** and ***CD58*** .	parallel	1
4001	10380930	914;965	CD2;CD58	These features explain ******CD2-CD58****** dynamic ***binding*** , offering insights into interactions of related immunoglobulin superfamily receptors .	parallel	1
4002	10381050	3586;3553	IL-10;IL-1beta	***IL-10*** ***correlated*** negatively with ***IL-1beta*** ( p = 0.013 ) and TNF-alpha ( p = 0.039 ) .	negative	0
4003	10381050	3586;7124	IL-10;TNF-alpha	***IL-10*** ***correlated*** negatively with IL-1beta ( p = 0.013 ) and ***TNF-alpha*** ( p = 0.039 ) .	negative	0
4004	10381168	3558;596	IL-2;Bcl-2	***Bcl-2*** downregulation and spontaneous apoptosis of T lymphocytes from HIV-infected individuals can be partially ***prevented*** by the exogeneous addition of ***IL-2*** , but not of IL-12 , IL-4 , or antibodies that prevent the CD95/CD95 ligand pathway of apoptosis .	negative	0
4005	10381168	3565;596	IL-4;Bcl-2	***Bcl-2*** downregulation and spontaneous apoptosis of T lymphocytes from HIV-infected individuals can be partially ***prevented*** by the exogeneous addition of IL-2 , but not of IL-12 , ***IL-4*** , or antibodies that prevent the CD95/CD95 ligand pathway of apoptosis .	negative	0
4006	10381170	373156;4899	GST;NRF1	Glutathione S-transferase ( GST ) pull-down experiments showed ***association*** of ***GST-Tax*** fusion protein with ***NRF1*** in vitro .	parallel	0
4007	10381257	10651;4580	metaxin 2;Metaxin 1	Metaxin 1 bound to a Ni2 + - chelate affinity column only in the presence of metaxin 2 , indicating that ***Metaxin 1*** and ***metaxin 2*** ***interact*** when overexpressed in insect cells .	parallel	1
4008	10381257	4580;10651	Metaxin 1;metaxin 2	***Metaxin 1*** ***interacts*** with ***metaxin 2*** , a novel related protein associated with the mammalian mitochondrial outer membrane .	parallel	1
4009	10381361	5617;356	PRL;FasL	These data suggest that the CD3-positive T lymphocyte in the CL is at least one of the PRL-effector cell species during the process of luteolysis in rats , and that ***FasL*** expression of these cells is ***upregulated*** by ***PRL*** .	positive	1
4010	10381377	6464;2885	Shc;Grb2	Although overexpression of SHIP2 did not affect insulin-induced tyrosine phosphorylation of the insulin receptor beta-subunit and Shc , subsequent ***association*** of ***Shc*** with ***Grb2*** was inhibited , possibly by competition between the SH2 domains of SHIP2 and Grb2 for the Shc phosphotyrosine .	parallel	0
4011	10381382	10163;10096	WAVE2;Arp2/3	Further , ***WAVE2*** and WAVE3 ***associate*** with the ***Arp2/3*** complex as does WAVE1 .	parallel	0
4012	10381382	10810;10096	WAVE3;Arp2/3	Further , WAVE2 and ***WAVE3*** ***associate*** with the ***Arp2/3*** complex as does WAVE1 .	parallel	0
4013	10381392	1984;7514	eIF-5A;CRM1	We are able to show that ***eIF-5A*** ***interacts*** with the general nuclear export receptor , ***CRM1*** .	parallel	1
4014	10381393	990;983	CDC6;Cdc2	The ***CDC6*** protein ***interacts*** in vivo with ***Cdc2*** kinase complexes .	parallel	1
4015	10381393	990;983	CDC6;Cdc2	Interestingly , ***CDC6*** is an in vitro ***substrate*** for ***Cdc13/Cdc2*** and Cig1/Cdc2 , but not for Cig2/Cdc2-associated kinases .	parallel	1
4016	10381499	6387;7852	SDF-1;CXCR4	These results suggest that ***CXCR4*** and its ***ligand*** ***SDF-1*** expressed in CD34 ( + ) progenitors may play an important role in regulating the local and systemic trafficking of these cells .	parallel	1
4017	10381499	3700;920	gp120;CD4	Moreover , these findings suggest multiple and potentially synergistic mechanisms at the basis of the resistance of CD34 ( + ) cells to X4 HIV infection , including their ability to produce SDF-1 , and the lack of CXCR4 internalization following ***gp120*** ***binding*** to ***CD4*** .	parallel	1
4018	10381499	6387;7852	stromal cell-derived factor-1;CXCR4	Human CD34 ( + ) cells express ***CXCR4*** and its ***ligand*** ***stromal cell-derived factor-1*** .	parallel	1
4019	10381499	6387;7852	stromal cell-derived factor-1;CXCR4	Human CD34 ( + ) hematopoietic progenitor cells obtained from bone marrow ( BM ) , umbilical cord blood ( UCB ) , and mobilized peripheral blood ( MPB ) were purified and investigated for the expression of the chemokine receptor ***CXCR4*** and its ***ligand*** , ***stromal cell-derived factor-1*** ( SDF-1 ) .	parallel	1
4020	10381501	2623;2056	GATA-1;erythropoietin	***GATA-1*** and ***erythropoietin*** ***cooperate*** to promote erythroid cell survival by regulating bcl-xL expression .	parallel	0
4021	10381501	2623;598	GATA-1;bcl-xL	Here we report that in erythroid cells , ***GATA-1*** strongly ***induces*** the expression of the anti-apoptotic protein ***bcl-xL*** , but not the related proteins bcl-2 and mcl-1 .	target	1
4022	10381501	2056;2623	erythropoietin;GATA-1	In addition , we show that ***erythropoietin*** , which is also required for erythroid cell survival , ***cooperates*** with ***GATA-1*** to stimulate bcl-xL gene expression and to maintain erythroid cell viability during terminal maturation .	parallel	0
4023	10381501	2056;598	erythropoietin;bcl-xL	In addition , we show that ***erythropoietin*** , which is also required for erythroid cell survival , cooperates with GATA-1 to ***stimulate*** ***bcl-xL*** gene expression and to maintain erythroid cell viability during terminal maturation .	positive	0
4024	10381534	4869;238	NPM;ALK	The tumor cells in both cases gave positive immunohistochemical labeling for ALK protein ( with both monoclonal and polyclonal antibodies ) , demonstrating that these translocations induce aberrant expression of this kinase and suggesting that genes other than ***NPM*** can ***activate*** the ***ALK*** gene in ALCL .	positive	1
4025	10381535	4352;7066	Mpl;thrombopoietin	The ***thrombopoietin*** ***receptor*** , ***Mpl*** , is a member of the cytokine receptor superfamily .	parallel	1
4026	10381539	627;2904	Brain-derived neurotrophic factor;NR2B	Our recent studies revealed that ***Brain-derived neurotrophic factor*** ( BDNF ) rapidly ***enhances*** tyrosine phosphorylation and dephosphorylation of the NMDA receptor subunit , ***NR2B*** , in the postsynaptic density ( PSD ) , potentially regulating synaptic plasticity .	positive	0
4027	10381546	5595;4741	Erk1;NF-M	In a previous study , we have demonstrated that a constitutively active form of MEK1 activates ***Erk1*** and Erk2 kinases , which ***phosphorylate*** co-transfected ***NF-M*** in NIH 3T3 cells .	target	1
4028	10381546	5594;4741	Erk2;NF-M	In a previous study , we have demonstrated that a constitutively active form of MEK1 activates Erk1 and ***Erk2*** kinases , which ***phosphorylate*** co-transfected ***NF-M*** in NIH 3T3 cells .	target	1
4029	10381547	3553;3557	IL-1beta;IL-1Ra	In both young and old rats , ***IL-1beta*** ***induced*** a significant up-regulation of cerebellar ***IL-1Ra*** , IL-1RI , and TGF-beta1 mRNAs ; hippocampal TGF-beta1 mRNA ; hypothalamic IL-1beta , IL-1Ra , TGF-beta1 , and gp 130 mRNAs ; and midbrain IL-1beta and TGF-beta1 mRNAs .	target	1
4030	10381566	4613;10397	N-myc;ndr1	***N-myc-dependent*** ***repression*** of ***ndr1*** , a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant .	negative	1
4031	10381566	10397;4613	ndr1;N-myc	To establish the direct ***link*** between ***N-myc*** activity and the ***ndr1*** regulation , the ndr1 gene was cloned and analyzed .	parallel	0
4032	10381566	4613;10397	N-myc;ndr1	The ***ndr1*** promoter activity was ***down-regulated*** by ***N-myc*** , and more strongly by the combination of N-myc and Max in the cotransfection assay .	negative	1
4033	10381567	5316;3211	PREP1;HOXB1	Human ***PREP1*** , a novel homeodomain protein of the TALE super-family , forms a stable DNA-binding complex with PBX proteins in solution , a ternary ***complex*** with PBX and ***HOXB1*** on DNA , and is able to act as a co-activator in the transcription of PBX-HOXB1 activated promoters ( Berthelsen , J. , Zappavigna , V. , Ferretti , E. , Mavilio , F. , Blasi , F. , 1998b .	parallel	1
4034	10381625	7157;355	p53;Fas	Recent evidence suggests an intriguing ***link*** between ***p53*** and the ***Fas*** pathway .	parallel	0
4035	10381630	356;355	CD95L;CD95	IAP proteins were not cleaved during ***CD95*** ***ligand*** ( ***CD95L*** ) - induced apoptosis , and loss of IAP protein expression was not responsible for the potentiation of CD95L-induced apoptosis when protein synthesis was inhibited .	parallel	1
4036	10381630	331;841	XIAP;caspase 8	However , ***XIAP*** failed to ***block*** ***caspase 8*** processing in LN-229 cells in the presence of CHX .	negative	0
4037	10381633	2247;836	bFGF;caspase-3	***bFGF*** ***inhibits*** the activation of ***caspase-3*** and apoptosis of P19 embryonal carcinoma cells during neuronal differentiation .	negative	1
4038	10381633	2247;836	bFGF;caspase-3	Basic fibroblast growth factor ( ***bFGF*** ) inhibited more than 90 % of the caspase-3-like activity , ***inhibited*** processing of ***caspase-3*** into its active form , and inhibited DNA fragmentation .	negative	1
4039	10381635	142;836	PARP;CPP32	In addition , poly - ( ADP-ribose ) polymerase ( ***PARP*** ) , a cellular ***substrate*** for ***CPP32*** protease was degraded to generate apoptotic fragments in Mn2 + - treated B cell lines .	parallel	1
4040	10381639	598;356	Bcl-XL;CD95-L	In addition , overexpression of ***Bcl-XL*** in CEM cells ***blocked*** doxorubicin-triggered ROS and ***CD95-L*** expression .	negative	0
4041	10381646	599;578	Bcl-w;Bak	Mutation of A1 at a highly conserved glycine within the BH1 domain prevented binding , but the comparable ***Bcl-w*** mutant still ***bound*** ***Bak*** , Bad and Bik , indicating that the glycine is not essential for all heterodimerization .	parallel	1
4042	10381646	599;638	Bcl-w;Bik	Mutation of A1 at a highly conserved glycine within the BH1 domain prevented binding , but the comparable ***Bcl-w*** mutant still ***bound*** Bak , Bad and ***Bik*** , indicating that the glycine is not essential for all heterodimerization .	parallel	1
4043	10381651	1019;595	cdk4;cyclin D1	Here we show that during early phase G1 arrest which occurs in UV-irradiated human U343 glioblastoma cells , there are ( 1 ) decreases in cyclin D1 and cdk4 levels which parallel a loss of S-phase promoting ******cyclin D1/cdk4****** ***complexes*** , and ( 2 ) increases in p53 and p21 protein levels .	parallel	1
4044	10381651	1019;595	cdk4;cyclin D1	We also show that the late phase UV-induced apoptosis of U343 cells occurs after cell cycle re-entry and parallels the reappearance of cyclin D1 and cdk4 and ******cyclin D1/cdk4****** ***complexes*** .	parallel	1
4045	10381819	355;356	Fas;Fas ligand	******Fas-Fas ligand****** ( FasL ) ***interactions*** play a significant role in the immune privilege status of certain cell populations , and several cytokines and growth factors can modulate their expression .	parallel	1
4046	10381821	6590;1991	Secretory leukocyte protease inhibitor;leukocyte elastase	***Secretory leukocyte protease inhibitor*** ( SLPI ) is a potent ***inhibitor*** of human ***leukocyte elastase*** .	negative	1
4047	10382071	11144;5888	DMC1;RAD51	The behaviour of ATR at meiotic prophase sets it apart from the distribution of the ******RAD51/DMC1****** recombinase ***complex*** and our electron microscope observations confirm that they do not co-localize .	parallel	1
4048	10382071	472;11144	Atm;DMC1	ATR , ***Atm*** and RAD1 , are ***associated*** with ***RAD51/DMC1*** recombination sites where DNA breaks are expected to be present , is therefore not supported by our observations .	parallel	0
4049	10382071	472;5888	Atm;RAD51	ATR , ***Atm*** and RAD1 , are ***associated*** with ***RAD51/DMC1*** recombination sites where DNA breaks are expected to be present , is therefore not supported by our observations .	parallel	0
4050	10382071	545;11144	ATR;DMC1	***ATR*** , Atm and RAD1 , are ***associated*** with ***RAD51/DMC1*** recombination sites where DNA breaks are expected to be present , is therefore not supported by our observations .	parallel	0
4051	10382071	545;5888	ATR;RAD51	***ATR*** , Atm and RAD1 , are ***associated*** with ***RAD51/DMC1*** recombination sites where DNA breaks are expected to be present , is therefore not supported by our observations .	parallel	0
4052	10382071	5810;11144	RAD1;DMC1	ATR , Atm and ***RAD1*** , are ***associated*** with ***RAD51/DMC1*** recombination sites where DNA breaks are expected to be present , is therefore not supported by our observations .	parallel	0
4053	10382071	5810;5888	RAD1;RAD51	ATR , Atm and ***RAD1*** , are ***associated*** with ***RAD51/DMC1*** recombination sites where DNA breaks are expected to be present , is therefore not supported by our observations .	parallel	0
4054	10382239	551;6647	antidiuretic hormone;ALS	Based on these findings , the patient was diagnosed as having the syndrome of inappropriate secretion of ***antidiuretic hormone*** ( SIADH ) ***associated*** with amyotrophic lateral sclerosis ( ***ALS*** ) .	parallel	0
4055	10382266	1634;7040	decorin;TGF-beta	***decorin*** ***binds*** to ***TGF-beta*** , thus inhibiting its bioactivity , and is a direct or indirect negative modulator of TGF-beta synthesis .	parallel	1
4056	10382266	1634;7040	decorin;TGF-beta	Here , we discuss ***interactions*** of ***decorin*** with ***TGF-beta*** and with p21 , both of which are relevant to carcinogenesis and tumor progression .	parallel	1
4057	10382302	6603;5705	BAF60b;thyroid hormone receptor interacting protein-1	Evidence for evolutionary conservation of a physical ***linkage*** between the human ***BAF60b*** , a subunit of SWI/SNF complex , and ***thyroid hormone receptor interacting protein-1*** genes on chromosome 17 .	parallel	0
4058	10382539	4149;4609	MAX;MYC	Repression mediated by MAD is thought to antagonize the transcriptional activation and proliferation-promoting functions of ******MYC-MAX****** ***heterodimers*** .	parallel	1
4059	10382588	7351;3952	UCP2;leptin	Although no association was found between the UCP2 exon 8 variant and overt obesity in British subjects , the ***UCP2*** genotype of obese women ( n = 83 ) ***correlated*** with fasting serum ***leptin*** concentration ( p = 0.006 ) in the presence of extreme obesity .	parallel	0
4060	10382740	8742;3725	TWEAK;c-jun	In contrast to TNF , ***TWEAK*** does only modestly ***activate*** NF-kappaB or ***c-jun*** N-terminal kinase ( JNK ) in Kym-1 cells .	positive	1
4061	10382740	8742;5599	TWEAK;JNK	In contrast to TNF , ***TWEAK*** does only modestly ***activate*** NF-kappaB or c-jun N-terminal kinase ( ***JNK*** ) in Kym-1 cells .	positive	1
4062	10382740	8742;4790	TWEAK;NF-kappaB	In contrast to TNF , ***TWEAK*** does only modestly ***activate*** ***NF-kappaB*** or c-jun N-terminal kinase ( JNK ) in Kym-1 cells .	positive	1
4063	10382744	7852;6387	CXCR4;stromal cell-derived factor-1	Expression of ***CXCR4*** , the ***receptor*** for ***stromal cell-derived factor-1*** on fetal and adult human lympho-hematopoietic progenitors .	parallel	1
4064	10382744	7852;6387	CXCR4;SDF-1	We investigated the expression of ***CXCR4*** , the ***receptor*** for ***SDF-1*** , on CD34 + cells from different hematopoietic sites and developmental stages .	parallel	1
4065	10382746	7006;3558	Tec;IL-2	***Tec*** kinase is involved in transcriptional ***regulation*** of ***IL-2*** and IL-4 in the CD28 pathway .	target	1
4066	10382746	7006;3565	Tec;IL-4	***Tec*** kinase is involved in transcriptional ***regulation*** of IL-2 and ***IL-4*** in the CD28 pathway .	target	1
4067	10382746	3932;7006	Lck;Tec	Here , we show in heterologous COS-7 cells that co-expression of Src family kinases such as Lck increases Tec activation or CD28-mediated Tec activation , whereas co-expression of kinase-dead ***Lck*** ***blocks*** Tec activation or CD28-mediated ***Tec*** activation .	negative	0
4068	10382746	940;7006	CD28;Tec	These data suggest that ***CD28*** ***activates*** ***Tec*** via Src family PTK .	positive	1
4069	10382758	718;1378	C3b;CR1	When compared to full-length ( 30 SCR ) soluble CR1 ( sCR1 ) , SCR ( 1-3 ) was significantly less potent in accord with a model involving multi-valent ***binding*** of ***C3b/C4b*** to ***CR1*** .	parallel	1
4070	10382758	721;1378	C4b;CR1	When compared to full-length ( 30 SCR ) soluble CR1 ( sCR1 ) , SCR ( 1-3 ) was significantly less potent in accord with a model involving multi-valent ***binding*** of ***C3b/C4b*** to ***CR1*** .	parallel	1
4071	10383008	3990;5741	hepatic lipase;parathormone	Uraemic hypertriglyceridaemia is due , in part , to lipoprotein lipase and ***hepatic lipase*** deficiencies , which are causally ***linked*** to excess ***parathormone*** ( PTH ) .	parallel	0
4072	10383008	4023;5741	lipoprotein lipase;parathormone	Uraemic hypertriglyceridaemia is due , in part , to ***lipoprotein lipase*** and hepatic lipase deficiencies , which are causally ***linked*** to excess ***parathormone*** ( PTH ) .	parallel	0
4073	10383053	1437;3717	GM-CSF;Jak2	In addition , ***GM-CSF*** ***induced*** ***Jak2*** , STAT5A , and STAT5B in BV-2 cells , as it does in monocytes and macrophages .	target	1
4074	10383053	1437;6776	GM-CSF;STAT5A	In addition , ***GM-CSF*** ***induced*** Jak2 , ***STAT5A*** , and STAT5B in BV-2 cells , as it does in monocytes and macrophages .	target	1
4075	10383053	1437;6777	GM-CSF;STAT5B	In addition , ***GM-CSF*** ***induced*** Jak2 , STAT5A , and ***STAT5B*** in BV-2 cells , as it does in monocytes and macrophages .	target	1
4076	10383054	5660;5594	Prosaposin;ERK	Recently , we demonstrated that ***Prosaposin*** and prosaptides ( peptides encompassing the neurotrophic sequence in Prosaposin ) ***prevent*** cell death and increase extracellular regulated kinase ( ***ERK*** ) phosphorylation and sulfatide content in primary Schwann cells or oligodendrocytes ( Hiraiwa et al. , 1997a ) .	negative	0
4077	10383113	4803;4914	NGF;TrkA	In this review , we will overview the evidence implicating specific signaling cascades in aspects of the cellular response to the neurotrophins , specifically in response to ***activation*** of ***TrkA*** by ***NGF*** .	positive	1
4078	10383128	8743;8795	TRAIL;KILLER/DR5	Molecular cloning and functional analysis of the mouse homologue of the ***KILLER/DR5*** tumor necrosis factor-related apoptosis-inducing ***ligand*** ( ***TRAIL*** ) death receptor .	parallel	1
4079	10383130	8626;7157	p63;p53	We found that ***p51/p63*** ***trans-activated*** the previously identified ***p53*** target genes , but the degree of the transactivation by p51/p63 differed from that by p53 .	positive	1
4080	10383144	3084;5829	HRG;paxillin	Because the process of cell migration must involve dynamic changes in the formation of new focal adhesions at the leading edge and dissolution of preexisting focal points , we explored the potential ***HRG*** ***regulation*** of ***paxillin*** , a major component of focal adhesion .	target	1
4081	10383144	3084;5829	HRG;paxillin	The observed HRG stimulation of paxillin mRNA expression was completely blocked by actinomycin D ( a transcriptional inhibitor ) as well as by cycloheximide ( a protein synthesis inhibitor ) , suggesting the involvement of an inducible protein factor ( s ) and transcriptional ***regulation*** of ***paxillin*** mRNA by ***HRG*** .	target	1
4082	10383144	3084;5829	HRG;paxillin	The observed ***HRG*** ***stimulation*** of ***paxillin*** mRNA expression was completely blocked by actinomycin D ( a transcriptional inhibitor ) as well as by cycloheximide ( a protein synthesis inhibitor ) , suggesting the involvement of an inducible protein factor ( s ) and transcriptional regulation of paxillin mRNA by HRG .	positive	0
4083	10383148	1464;373156	NG2;GST	In addition , direct ***binding*** between GST-TAASGVRSMH and ***GST-LTLRWVGLMS*** fusion proteins and ***NG2*** was demonstrated in solid-phase binding assays .	parallel	1
4084	10383163	1051;3553	NF-IL6;IL-1beta	Treatment with the FTase inhibitors resulted in a concentration-dependent decrease in both ***NF-IL6/CREB*** ***binding*** to the ***IL-1beta*** promoter and IL-1beta protein levels , without a significant change in total cellular protein levels .	parallel	1
4085	10383394	960;3458	CD44;interferon-gamma	***CD44*** , a cell surface chondroitin sulfate proteoglycan , ***mediates*** binding of ***interferon-gamma*** and some of its biological effects on human vascular smooth muscle cells .	target	0
4086	10383403	5590;10818	PKC zeta;FRS2	***PKC zeta*** , the other member of the atypical PKC subfamily , could also ***bind*** ***FRS2*** .	parallel	1
4087	10383426	1471;115209	cystatin C;peptidase	We have investigated the ***inhibition*** of the recently identified family C13 cysteine ***peptidase*** , pig legumain , by human ***cystatin C*** .	negative	1
4088	10383426	5641;1471	legumain;cystatin C	A ternary ***complex*** between ***legumain*** , ***cystatin C*** , and papain was demonstrated by gel filtration supported by immunoblotting .	parallel	1
4089	10383427	3949;4018	LDLR;lipoprotein	To evaluate the contribution of the macrophage low density ***lipoprotein*** ***receptor*** ( ***LDLR*** ) to atherosclerotic lesion formation , we performed bone marrow transplantation studies in different mouse strains .	parallel	1
4090	10383440	6774;5008	STAT3;oncostatin M	Moreover , ***dn-STAT3*** ***blocked*** the ability of either IL-6 + soluble IL-6 receptor or ***oncostatin M*** to induce RANKL .	negative	0
4091	10383452	973;959	Igalpha;IgM	Finally , the ***Igalpha/Igbeta*** heterodimers ***associated*** with fully assembled ***IgM*** molecules as a terminal event in B cell receptor assembly .	parallel	0
4092	10383452	974;959	Igbeta;IgM	Finally , the ***Igalpha/Igbeta*** heterodimers ***associated*** with fully assembled ***IgM*** molecules as a terminal event in B cell receptor assembly .	parallel	0
4093	10383452	974;973	Igbeta;Igalpha	Finally , the ******Igalpha/Igbeta****** ***heterodimers*** associated with fully assembled IgM molecules as a terminal event in B cell receptor assembly .	parallel	1
4094	10383460	7329;367	Ubc9;androgen receptor	***Ubc9*** ***interacts*** with the ***androgen receptor*** and activates receptor-dependent transcription .	parallel	1
4095	10383609	2353;3725	C-fos;c-jun	We investigated the role of ***C-fos*** ***dimerizing*** with ***c-jun*** in controlling the induction of maternal behaviour , altered peptide gene expression , and oxytocin and amino acid release in this region at birth .	parallel	1
4096	10383816	959;836	IgM;CPP32	In each instance where microfilament assembly is inhibited , ***anti-IgM-induced*** ***activation*** of the protease ***CPP32*** ( caspase ) is also inhibited .	positive	1
4097	10383823	3558;3001	interleukin 2;granzyme A	***interleukin 2*** ***increased*** ***granzyme A*** protein expression independent of alcohol consumption ; however , this increase was associated with decreased enzyme activity .	positive	0
4098	10383894	3077;7037	HFE;TFR	The HFE wild-type gene product complexes with the transferrin receptor ( TF ) and two different ***HFE*** mutations ( Cys282Tyr and His63Asp ) have been found to ***increase*** the affinity of ***TFR*** for TF and increase cellular iron uptake .	negative	0
4099	10383894	7037;3077	TFR;HFE	In a recent study we found no associations for HFE and TFR separately , but an ***interaction*** between ***HFE*** and ***TFR*** genotypes in multiple myeloma .	parallel	1
4100	10383894	7037;3077	TFR;HFE	Thus , an ***interaction*** between ***HFE*** and ***TFR*** alleles may increase the risk for different neoplastic disorders .	parallel	1
4101	10383941	960;2885	CD44;Grb2	We found that ***CD44*** cross-linking by mAb in CD4 ( + ) peripheral blood T cells ***promotes*** formation of a trimeric complex of ***Grb2*** , phospholipase ( PLC ) - gamma1 and a 36-38 kDa phosphoprotein , and the activation of PLC-gamma1 .	positive	0
4102	10383941	2885;5335	Grb2;PLC-gamma1	We found that CD44 cross-linking by mAb in CD4 ( + ) peripheral blood T cells promotes formation of a trimeric ***complex*** of ***Grb2*** , phospholipase ( PLC ) - gamma1 and a 36-38 kDa phosphoprotein , and the activation of ***PLC-gamma1*** .	parallel	1
4103	10383941	960;920	CD44;CD4	Co-capping , co-immunoprecipitation and fluorescence resonance energy transfer experiments showed that ***CD44*** ***associates*** with ***CD4*** and CD3 on the cell surface .	parallel	0
4104	10383941	920;960	CD4;CD44	This association suggests functional ***interplay*** between the ***CD4-TCR*** complex and ***CD44*** .	parallel	1
4105	10383941	3700;920	gp120;CD4	In line with this possibility , we found that CD4 triggering by ***gp120*** , a natural ***ligand*** of ***CD4*** , potentiates CD44-mediated adhesion to hyaluronic acid .	parallel	1
4106	10384100	940;941	CD28;B7.1	In this study , we have evaluated the potential of human ******B7.1-CD28****** ***interaction*** as an activating trigger for human blood NK cells .	parallel	1
4107	10384102	958;959	CD40;CD40 ligand	We conclude that CD4 + T cells play a critical role in the generation of antitumor immune responses through their capacity to induce the activation of DC via ******CD40/CD40 ligand****** ***interaction*** , and thus maximize CD8 + T cell responses .	parallel	1
4108	10384104	959;958	CD40L;CD40	This study demonstrates that Ag-activated CD4 + NKT cells express ***CD40*** ***ligand*** ( ***CD40L*** ) ( CD154 ) , which engages CD40 on APC and stimulates them to produce IL-12 .	parallel	1
4109	10384107	940;3558	CD28;IL-2	We find that ***CD28*** signaling acts transiently to ***stabilize*** the ***IL-2*** mRNA following T cell activation .	positive	0
4110	10384135	7295;4792	TRX;IkappaBalpha	Consistent with these findings , the ***IkappaBalpha*** phosphorylation at Ser32 and its subsequent degradation in response to TNF-alpha was ***facilitated*** by ***TRX*** .	positive	0
4111	10384135	1401;7124	C-reactive protein;TNF-alpha	Multiple regression analysis revealed that the serum ***C-reactive protein*** value was better ***correlated*** with the linear combination of SF ***TNF-alpha*** and SF TRX values than with SF TNF-alpha alone , suggesting that TRX might play a subsidiary role in the rheumatoid inflammation .	parallel	0
4112	10384140	653509;929	SP-A;CD14	These results demonstrate the different actions of SP-A upon distinct serotypes of LPS and indicate that the direct ***interaction*** of ***SP-A*** with ***CD14*** constitutes a likely mechanism by which SP-A modulates LPS-elicited cellular responses .	parallel	1
4113	10384140	653509;7124	SP-A;TNF-alpha	In the macrophage-like cell line U937 , ***SP-A*** ***inhibited*** mRNA expression and secretion of ***TNF-alpha*** induced by smooth LPS , but rough LPS-induced TNF-alpha expression was unaffected by SP-A .	negative	1
4114	10384140	653509;929	SP-A;CD14	To clarify the mechanism by which SP-A modulates LPS-elicited cellular responses , we further examined the ***interaction*** of ***SP-A*** with ***CD14*** , which is known as a major LPS receptor .	parallel	1
4115	10384140	653509;929	SP-A;CD14	In addition , ***SP-A*** directly ***bound*** to recombinant soluble ***CD14*** ( rsCD14 ) .	parallel	1
4116	10384144	5747;1234	FAK;CCR5	HIV envelope-induced cellular ***association*** of ***FAK*** and ***CCR5*** was also demonstrated , suggesting that ligation of CD4 and CCR5 leads to the formation of an activation complex composed of FAK and CCR5 .	parallel	0
4117	10384145	3551;4790	IKK-2;NF-kappa B	This is the first demonstration that ***IKK-2*** is a pivotal ***regulator*** of ***NF-kappa B*** in primary human cells .	target	1
4118	10384146	4982;8600	osteoclastogenesis inhibitory factor;ODF	A soluble form of RANK as well as ***osteoprotegerin/osteoclastogenesis inhibitory factor*** , a decoy ***receptor*** of ***ODF*** , blocked OCL formation and prevented the survival , multinucleation , and pit-forming activity of pOCs induced by sODF .	parallel	1
4119	10384149	3567;241	IL-5;FLAP	We hypothesized that ***IL-5*** ***induces*** the expression of 5-LO and/or its activating protein ***FLAP*** in eosinophils , and that this might be modulated by anti-inflammatory corticosteroids .	target	1
4120	10384149	3567;241	IL-5;FLAP	Compared with control cultures , ***IL-5*** increased the proportion of normal blood eosinophils immunostaining for FLAP ( 65 + / - 4 vs 34 + / - 4 % ; p < 0.0001 ) , ***enhanced*** immunoblot levels of ***FLAP*** by 51 + / - 14 % ( p = 0.03 ) , and quadrupled ionophore-stimulated leukotriene C4 synthesis from 5.7 to 20.8 ng/106 cells ( p < 0.02 ) .	positive	0
4121	10384149	3567;241	IL-5;FLAP	Thus , ***IL-5*** ***increases*** ***FLAP*** expression and translocates 5-LO to the nucleus in normal blood eosinophils in vitro .	positive	0
4122	10384156	958;941	CD40;B7-1	Neither IFN-gamma plus TNF-alpha nor ***CD40*** stimulation significantly ***induced*** ***B7-1*** or up-regulated B7-2 on human myeloma cell line or primary myeloma cells from six of seven patients .	target	1
4123	10384156	958;942	CD40;B7-2	Neither IFN-gamma plus TNF-alpha nor ***CD40*** stimulation significantly ***induced*** B7-1 or up-regulated ***B7-2*** on human myeloma cell line or primary myeloma cells from six of seven patients .	target	1
4124	10384156	3458;941	IFN-gamma;B7-1	Neither ***IFN-gamma*** plus TNF-alpha nor CD40 stimulation significantly ***induced*** ***B7-1*** or up-regulated B7-2 on human myeloma cell line or primary myeloma cells from six of seven patients .	target	1
4125	10384156	3458;942	IFN-gamma;B7-2	Neither ***IFN-gamma*** plus TNF-alpha nor CD40 stimulation significantly ***induced*** B7-1 or up-regulated ***B7-2*** on human myeloma cell line or primary myeloma cells from six of seven patients .	target	1
4126	10384156	7124;941	TNF-alpha;B7-1	Neither IFN-gamma plus ***TNF-alpha*** nor CD40 stimulation significantly ***induced*** ***B7-1*** or up-regulated B7-2 on human myeloma cell line or primary myeloma cells from six of seven patients .	target	1
4127	10384156	7124;942	TNF-alpha;B7-2	Neither IFN-gamma plus ***TNF-alpha*** nor CD40 stimulation significantly ***induced*** B7-1 or up-regulated ***B7-2*** on human myeloma cell line or primary myeloma cells from six of seven patients .	target	1
4128	10384404	796;54826	CGRP;Gin-1	When cells were pretreated with PD98059 , a selective inhibitor of MAPK kinase ( also known as MEK ) , ***CGRP*** not only failed to induce phosphorylation of MAPK but also failed to ***stimulate*** ***Gin-1*** cell proliferation .	positive	0
4129	10384879	7124;3398	TNF alpha;Id2	***TNF alpha*** also ***increased*** ***Id2*** mRNA expression in the caudate putamen and hippocampus at the injection site .	positive	0
4130	10384880	4916;4908	TrkC;Neurotrophin-3	***Neurotrophin-3*** ( NT-3 ) and its ***receptor*** ***TrkC*** are known to be important for neuronal survival .	parallel	1
4131	10384911	7432;3458	VIP;interferon gamma	***VIP*** , at 10 ( -5 ) mol/l and serotonin at 10 ( -4 ) mol/l ***stimulated*** the secretion of ***interferon gamma*** .	positive	0
4132	10384959	3329;3336	GroEL;GroES	The dynamic ***interaction*** of ***GroEL*** and ***GroES*** is regulated by the GroEL ATPase and involves the formation of asymmetrical GroEL : GroES1 and symmetrical GroEL : GroES2 complexes .	parallel	1
4133	10384959	3329;3336	GroEL;GroES	The dynamic interaction of GroEL and ***GroES*** is ***regulated*** by the ***GroEL*** ATPase and involves the formation of asymmetrical GroEL : GroES1 and symmetrical GroEL : GroES2 complexes .	target	1
4134	10385244	4363;3569	MRP1;IL-6	These results indicate that the membrane transporter ***MRP1*** is involved in the ***regulation*** of ***IL-6*** expression in activated human peripheral blood monocytes .	target	1
4135	10385249	2056;4843	erythropoietin;iNOS	Recombinant human ***erythropoietin*** ***inhibits*** ***iNOS*** activity and reverts vascular dysfunction in splanchnic artery occlusion shock .	negative	1
4136	10385397	7124;3939	Tumor necrosis factor-alpha;lactate dehydrogenase A	***Tumor necrosis factor-alpha*** ***stimulates*** ***lactate dehydrogenase A*** expression in porcine cultured sertoli cells : mechanisms of action .	positive	0
4137	10385398	7124;4155	TNF-alpha;MBP	While ***TNF-alpha*** ***decreased*** ***MBP*** and PLP mRNA abundance by 5 - to 6-fold , IGF-I abrogated TNF-alpha-induced reductions in a dose - and time-dependent manner .	negative	0
4138	10385398	7124;5354	TNF-alpha;PLP	While ***TNF-alpha*** ***decreased*** MBP and ***PLP*** mRNA abundance by 5 - to 6-fold , IGF-I abrogated TNF-alpha-induced reductions in a dose - and time-dependent manner .	negative	0
4139	10385400	3479;3485	IGF-I;IGFBP-2	Affinity cross-linking of [ 125I ] IGF-I to neuroblastoma cell membranes followed by immunoprecipitation revealed a approximately 38 kDa [ 125I ] ******IGF-I/IGFBP-2****** ***complex*** .	parallel	1
4140	10385409	5741;5744	PTH;PTHrP	Similarly , ***PTH*** ( 1-34 ) treatment for 48 h ***abolished*** ***PTHrP*** binding to cell surface receptors ; however , neither the PTH analogs nor the cAMP regulating agents altered PTH binding or numbers of binding sites on osteoblastic cells .	negative	0
4141	10385409	5741;632	PTH;OCN	THFA and PTH ( 7-34 ) - treated cultures had increased OCN expression ; whereas , ***PTH*** ( 1-34 ) and forskolin ***reduced*** ***OCN*** expression .	negative	1
4142	10385410	5594;3480	ERK2;insulin-like growth factor 1 receptor	Prolonged activation of ***ERK2*** by epidermal growth factor and other growth factors ***requires*** a functional ***insulin-like growth factor 1 receptor*** .	target	0
4143	10385413	4852;3952	NPY;leptin	It was found that the combined i.c.v. infusion of ***NPY*** and dexamethasone in ADX rats ***increased*** food intake , body weight , plasma insulin , ***leptin*** , and triglyceride levels relative to vehicle-infused ADX controls .	positive	0
4144	10385418	3458;834	IFNgamma;caspase 1	Apoptosis in NIT-1 cells was increased by coincubation with ***IFNgamma*** , which also ***increased*** ***caspase 1*** expression .	positive	0
4145	10385423	7200;5443	thyrotropin-releasing hormone;alpha-melanocyte-stimulating hormone	Involvement of protein kinase C and protein tyrosine kinase in ***thyrotropin-releasing hormone-induced*** ***stimulation*** of ***alpha-melanocyte-stimulating hormone*** secretion in frog melanotrope cells .	positive	0
4146	10385500	6868;7124	TACE;TNF-alpha	CONCLUSIONS : This study has shown that increased myocardial ***TACE*** expression is ***associated*** with elevated myocardial ***TNF-alpha*** expression in both mRNA and protein levels in clinically advanced DCM .	parallel	0
4147	10385525	5747;5599	FAK;JNK	******FAK-JNK****** ***signaling*** was necessary for proper progression through the G1 phase of the cell cycle .	parallel	0
4148	10385526	7128;4790	A20;NF-kappaB	Moreover , ***NF-kappaB*** activation induced by overexpression of the TNF receptor-associated proteins TNF receptor-associated death domain protein ( TRADD ) , receptor interacting protein ( RIP ) , and TNF recep - tor-associated factor 2 ( TRAF2 ) was also ***inhibited*** by expression of ***A20*** , whereas NF-kappaB activation induced by overexpression of NF-kappaB-inducing kinase ( NIK ) or the human T cell leukemia virus type 1 ( HTLV-1 ) Tax was unaffected .	negative	1
4149	10385551	7157;3308	p53;HSP70	Wild-type ***p53*** has been reported to ***repress*** ***HSP70*** gene expression .	negative	1
4150	10385551	3308;7157	HSP70;p53	It has been shown that mutant ******p53-HSP70****** ***complex*** is highly expressed in cancer .	parallel	1
4151	10385598	3553;5743	IL-1beta;COX-2	Moreover , ***IL-1beta*** ***induced*** ***COX-2*** expression in both cell types .	target	1
4152	10385598	3553;4843	IL-1beta;iNOS	By contrast , ***IL-1beta*** ***stimulated*** the expression of ***iNOS*** protein in rat cells only .	positive	0
4153	10385599	10724;5706	beta-hexosaminidase;p44	***beta-hexosaminidase-induced*** ***activation*** of ***p44/42*** mitogen-activated protein kinase is dependent on p21Ras and protein kinase C and mediates bovine airway smooth-muscle proliferation .	positive	1
4154	10385613	3952;3725	Leptin;c-Jun	In addition , ***Leptin*** ***activated*** the NH2-terminal ***c-Jun*** kinase/stress-activated protein kinase pathway as demonstrated by enhanced JNK activity and AP-1 DNA binding .	positive	1
4155	10385613	3952;4790	Leptin;NF-kappaB	***NF-kappaB*** , another redox-sensitive transcription factor , was also ***activated*** by ***Leptin*** stimulation in an oxidant-dependent manner .	positive	1
4156	10385613	3725;6347	AP-1;monocyte chemoattractant protein-1	Finally , activation of both ***AP-1*** and NF-kappaB was ***associated*** with an enhanced expression of the ***monocyte chemoattractant protein-1*** in HUVEC .	parallel	0
4157	10385613	4790;6347	NF-kappaB;monocyte chemoattractant protein-1	Finally , activation of both AP-1 and ***NF-kappaB*** was ***associated*** with an enhanced expression of the ***monocyte chemoattractant protein-1*** in HUVEC .	parallel	0
4158	10385629	23462;997	Hrt1;Cdc34	***Hrt1*** assembles into recombinant SCF complexes and individually ***binds*** Cdc4 , Cdc53 and ***Cdc34*** , but not Skp1 .	parallel	1
4159	10385629	23462;55294	Hrt1;Cdc4	***Hrt1*** assembles into recombinant SCF complexes and individually ***binds*** ***Cdc4*** , Cdc53 and Cdc34 , but not Skp1 .	parallel	1
4160	10385629	23462;6500	Hrt1;Skp1	***Hrt1*** assembles into recombinant SCF complexes and individually ***binds*** Cdc4 , Cdc53 and Cdc34 , but not ***Skp1*** .	parallel	1
4161	10385629	23462;4254	Hrt1;SCF	***Hrt1*** ***stimulates*** the E3 activity of recombinant ***SCF*** potently and enables the reconstitution of Cln2 ubiquitination by recombinant SCFGrr1 .	positive	0
4162	10385629	23493;8454	HRT2;CUL-1	The highly conserved human Hrt1 complements the lethality of hrt1Delta , and human ***HRT2*** ***binds*** ***CUL-1*** .	parallel	1
4163	10385651	3082;598	HGF;Bcl-xL	Moreover , ***HGF*** strongly ***induced*** ***Bcl-xL*** expression and blocked apoptotic signal transduction upstream of CPP32 ( caspase-3 ) in the liver , thereby leading to inhibition of massive hepatocyte apoptosis .	target	1
4164	10385656	7040;356	TGF-beta;CD95L	***TGF-beta*** and TNF-alpha significantly ***reduced*** expression of ***CD95L*** in activated HSCs , whereas CD95 expression remained unchanged .	negative	1
4165	10385656	7124;356	TNF-alpha;CD95L	TGF-beta and ***TNF-alpha*** significantly ***reduced*** expression of ***CD95L*** in activated HSCs , whereas CD95 expression remained unchanged .	negative	1
4166	10385657	3586;2920	IL-10;MIP-2	***IL-10*** ***suppressed*** NFkappaB activation as well as messenger RNA expression of tumor necrosis factor-alpha ( TNF-alpha ) and macrophage inflammatory protein-2 ( ***MIP-2*** ) .	negative	1
4167	10385657	3586;7124	IL-10;TNF-alpha	***IL-10*** ***suppressed*** NFkappaB activation as well as messenger RNA expression of tumor necrosis factor-alpha ( ***TNF-alpha*** ) and macrophage inflammatory protein-2 ( MIP-2 ) .	negative	1
4168	10385657	3586;4790	IL-10;NFkappaB	***IL-10*** ***suppressed*** ***NFkappaB*** activation as well as messenger RNA expression of tumor necrosis factor-alpha ( TNF-alpha ) and macrophage inflammatory protein-2 ( MIP-2 ) .	negative	1
4169	10385657	3586;2920	IL-10;MIP-2	In addition , ***IL-10*** ***reduced*** serum levels of TNF-alpha and ***MIP-2*** .	negative	1
4170	10385657	3586;7124	IL-10;TNF-alpha	In addition , ***IL-10*** ***reduced*** serum levels of ***TNF-alpha*** and MIP-2 .	negative	1
4171	10385700	4804;627	p75;neurotrophin	L-753 ,000 was effective at nanomolar concentrations in a Chinese hamster ovary cell line that expressed TrkA but was devoid of ***p75*** , the low-affinity ***neurotrophin*** ***receptor*** .	parallel	1
4172	10385700	4908;4914	NT-3;TrkA	Because L-753 , 000 selectively potentiates the ***NT-3-induced*** ***stimulation*** of ***TrkA*** without inhibiting Trks and other protein kinases , it represents a novel class of selective modifiers of neurotrophin actions .	positive	0
4173	10385702	2247;5594	FGF-2;mitogen-activated protein kinase-1	Moreover , the polysulfonates PSS and PAS inhibited ***FGF-2-induced*** ***activation*** of ***mitogen-activated protein kinase-1/2*** , involved in FGF-2 signal transduction .	positive	1
4174	10385702	2247;2260	FGF-2;FGFR-1	The antiproliferative activity of these compounds was associated with the abrogation of ***FGF-2-induced*** tyrosine ***phosphorylation*** of ***FGFR-1*** .	target	1
4175	10385705	10267;3375	RAMP 1;amylin	Cotransfection of ***RAMP 1*** or RAMP 3 with the human CT receptor lacking the 16-amino acid insert in intracellular domain 1 ( hCTRI1 - ) into COS-7 cells ***induced*** specific 125I-labeled rat ***amylin*** binding .	target	1
4176	10385705	10268;3375	RAMP 3;amylin	Cotransfection of RAMP 1 or ***RAMP 3*** with the human CT receptor lacking the 16-amino acid insert in intracellular domain 1 ( hCTRI1 - ) into COS-7 cells ***induced*** specific 125I-labeled rat ***amylin*** binding .	target	1
4177	10386007	5972;183	renin;angiotensinogen	These results suggest the possibility that CG ***renin*** is transferred to the uterine epithelium at mating and temporarily ***activates*** the expression of ***angiotensinogen*** in the uterus .	positive	1
4178	10386600	1017;6502	Cdk2;Skp2	In addition , cyclin ***A/Cdk2*** complexes from regenerating liver clearly ***interacted*** with ***Skp2*** .	parallel	1
4179	10386606	183;5594	angiotensin II;extracellular signal-regulated kinase 1/2	***Activation*** of ***extracellular signal-regulated kinase 1/2*** by ***angiotensin II*** is a multistep process involving both its phosphorylation by mitogen-activated protein kinase extracellular signal-regulated kinase kinase in the cytoplasm and a subsequent translocation to the nucleus .	positive	1
4180	10386606	183;5594	angiotensin II;extracellular signal-regulated kinase 1/2	In contrast , ***angiotensin II-induced*** ***activation*** of protein kinase Czeta and ***extracellular signal-regulated kinase 1/2*** in the nucleus were both inhibited by troglitazone .	positive	1
4181	10386610	7124;6352	tumor necrosis factor-alpha;RANTES	In A549 cells , interleukin-1beta and ***tumor necrosis factor-alpha*** ***induced*** endogenous ***RANTES*** protein secretion , mRNA expression , and promoter activity .	target	1
4182	10386612	5266;1991	Elafin;neutrophil elastase	***Elafin*** ( elastase-specific inhibitor ) is a low molecular weight ***inhibitor*** of ***neutrophil elastase*** which is secreted in the lung .	negative	1
4183	10386854	1051;4790	NF-IL-6;NF-kappaB	AP-1 and ***NF-IL-6*** physically ***interact*** with ***NF-kappaB*** , and functional cooperativity among the factors appears to be critical for optimal IL-8 promoter activity in different cell types .	parallel	1
4184	10386953	627;5781	BDNF;Shp2	In PC12 cells stably expressing TrkB , both ***BDNF*** and nerve growth factor ***stimulated*** ***Shp2*** signaling similarly to that by BDNF in cultured cortical neurons .	positive	0
4185	10386953	4803;5781	nerve growth factor;Shp2	In PC12 cells stably expressing TrkB , both BDNF and ***nerve growth factor*** ***stimulated*** ***Shp2*** signaling similarly to that by BDNF in cultured cortical neurons .	positive	0
4186	10386953	5781;627	Shp2;BDNF	These results indicated that Shp2 shows cross-talk with various signaling molecules including Grb2 and PI3-K in BDNF-induced signaling and that ***Shp2*** may be involved in the ***regulation*** of various actions of ***BDNF*** in CNS neurons .	target	1
4187	10386953	5781;2885	Shp2;Grb2	Brain-derived neurotrophic factor stimulates ***interactions*** of ***Shp2*** with phosphatidylinositol 3-kinase and ***Grb2*** in cultured cerebral cortical neurons .	parallel	1
4188	10386953	627;5781	Brain-derived neurotrophic factor;Shp2	***Brain-derived neurotrophic factor*** ***stimulates*** interactions of ***Shp2*** with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons .	positive	0
4189	10386953	627;4915	BDNF;TrkB	This BDNF-stimulated Shp2 signaling was markedly sustained as well as ***BDNF-induced*** ***phosphorylation*** of ***TrkB*** and mitogen-activated protein kinases .	target	1
4190	10386956	2668;7054	GDNF;tyrosine hydroxylase	NTN was found to be as potent as GDNF at preventing the death of nigral dopaminergic neurons , but only ***GDNF*** ***induced*** ***tyrosine hydroxylase*** staining , sprouting , or hypertrophy of dopaminergic neurons .	target	1
4191	10386963	6714;5179	Src;proenkephalin	We have found that the inhibition of Src-related nonreceptor tyrosine kinases blocks forskolin-induced proenkephalin gene expression without having any effect on serine-133-phosphorylated CREB levels and that constitutively activated ***Src*** kinase can ***activate*** the ***proenkephalin*** promoter .	positive	1
4192	10387086	7018;7037	transferrin;hTfR	The dissociation constant for the equilibrium ***binding*** of TMR-labeled ***ferri-transferrin*** to ***hTfR*** in detergent free solution was determined to be 7 + / - 3 nM .	parallel	1
4193	10387091	6590;1511	mucus proteinase inhibitor;cathepsin G	***Inhibition*** of neutrophil ***cathepsin G*** by oxidized ***mucus proteinase inhibitor*** .	negative	1
4194	10387091	1511;6590	cathepsin G;MPI	The Ki of the oxidized ******MPI-cathepsin G****** ***complex*** ( 1.2 microM ) is probably too high to be compatible with significant inhibition of cathepsin G in inflammatory lung secretions .	parallel	1
4195	10387091	6590;1511	MPI;cathepsin G	Stopped-flow kinetics shows that , within the inhibitor concentration range used , the mechanism of ***inhibition*** of ***cathepsin G*** and chymotrypsin by oxidized ***MPI*** is consistent with a one-step reaction , [ equation in text ] whereas the inhibition of elastase takes place in two steps , [ equation in text ] .	negative	1
4196	10387091	6590;1511	MPI;cathepsin G	In the presence of heparin , oxidized ***MPI*** ***inhibits*** ***cathepsin G*** via a two-step reaction characterized by Ki = 0.22 microM , k2 = 0.1 s-1 , k-2 = 0.023 s-1 , and Ki = 42 nM .	negative	1
4197	10387976	3716;1441	JAK-1;G-CSF receptor	The ***G-CSF receptor*** signal is ***mediated*** by the ***JAK-1*** and JAK-2 tyrosine kinases .	target	0
4198	10387976	3717;1441	JAK-2;G-CSF receptor	The ***G-CSF receptor*** signal is ***mediated*** by the JAK-1 and ***JAK-2*** tyrosine kinases .	target	0
4199	10388012	5777;3717	SH-PTP1;JAK2	Conversely , the tyrosine phosphatase ***SH-PTP1*** ( also called HCP ) that has an SH2 domain and is specific to blood cells associates with the tyrosine phosphorylation site of the receptor and ***promotes*** the dephosphorylation of ***JAK2*** .	positive	0
4200	10388523	3082;4233	HGF;c-met	These findings suggest a model in which ***HGF*** ***binding*** to luminally accessible ***c-met*** stimulates gtk activity .	parallel	1
4201	10388534	841;836	Caspase-8;caspase-3	***Caspase-8*** ***mediates*** ***caspase-3*** activation and cytochrome c release during singlet oxygen-induced apoptosis of HL-60 cells .	target	0
4202	10388534	841;836	Caspase-8;caspase-3	In addition , blockade of ***Caspase-8*** by Z-IETD-FMK ***inhibited*** cleavage of ***pro-caspase-3*** and prevented loss of mitochondrial cytochrome c.	positive	1
4203	10388534	841;836	Caspase-8;caspase-3	These results suggest that ***Caspase-8*** ***mediates*** ***caspase-3*** activation and cytochrome c release during singlet oxygen-induced apoptosis in HL-60 cells .	target	0
4204	10388535	7040;4790	TGF-beta1;NF-kappaB	***TGF-beta1*** ***inhibits*** ***NF-kappaB*** activity through induction of IkappaB-alpha expression in human salivary gland cells : a possible mechanism of growth suppression by TGF-beta1 .	negative	1
4205	10388535	7040;4790	TGF-beta;NF-kappaB	Although accumulated evidence indicates the mechanisms of the antimitogenic effect of TGF-beta in a variety of cell types , the signal transduction mechanism underlying the ***regulation*** of ***NF-kappaB*** transcription factor by ***TGF-beta*** is largely unknown .	target	1
4206	10388535	7040;4790	TGF-beta1;NF-kappaB	These results indicate that ***TGF-beta1*** ***downregulates*** ***NF-kappaB*** activity through the induction of IkappaB-alpha expression in human salivary gland cells and that inhibition of NF-kappaB activity suppresses the growth rate of these cells .	negative	1
4207	10388747	3598;3596	IL-13R;IL-13	To understand the mechanisms of interaction between IL-13 and ***IL-13*** ***receptors*** ( ***IL-13R*** ) , and the role of the IL-2 receptor common gamma chain ( gammac ) in IL-13 binding and processing , we have examined IL-13 binding kinetics , dissociation/shedding , and internalization in renal cell carcinoma ( RCC ) cell lines .	parallel	1
4208	10388747	3598;3596	IL-13R;IL-13	To understand the mechanisms of ***interaction*** between ***IL-13*** and IL-13 receptors ( ***IL-13R*** ) , and the role of the IL-2 receptor common gamma chain ( gammac ) in IL-13 binding and processing , we have examined IL-13 binding kinetics , dissociation/shedding , and internalization in renal cell carcinoma ( RCC ) cell lines .	parallel	1
4209	10389198	5054;5327	PAI-1;tPA	An impaired fibrinolytic function , as evidenced by increased plasma concentrations of PAI-1 , tPA antigen and ******tPA/PAI-1****** ***complex*** , or a decreased capacity to release active tPA on exercise , is more common in individuals suffering from myocardial infarction .	parallel	1
4210	10389198	5054;5327	PAI-1;tPA	There is a highly statistically significant correlation between ******tPA/PAI-1****** ***complex*** and both PAI-1 and tPA antigen .	parallel	1
4211	10389210	7139;7137	cTnT;cTnI	With recombinant or in vitro formed ternary ******cTnI-cTnT-TnC****** ***complexes*** the differences were smaller ( 3-fold ) .	parallel	1
4212	10389210	7139;7134	cTnT;TnC	With recombinant or in vitro formed ternary ******cTnI-cTnT-TnC****** ***complexes*** the differences were smaller ( 3-fold ) .	parallel	1
4213	10389210	7134;7137	TnC;cTnI	With recombinant or in vitro formed ternary ******cTnI-cTnT-TnC****** ***complexes*** the differences were smaller ( 3-fold ) .	parallel	1
4214	10389215	338;335	apolipoprotein B;apo	More precisely , being working on 119 families we have showed that : a ) The apolipoprotein E ( apo E ) common polymorphism is involved in the total cholesterol , low density lipoprotein cholesterol ( LDL-Chol ) , apo E , apo B levels variability , b ) the apolipoprotein A-IV gene had no effect on lipid metabolism parameters variability , apo A-IV levels included , c ) the ***apolipoprotein B*** gene was ***associated*** with total cholesterol , high density lipoprotein cholesterol , LDL-Chol , triglycerides and ***apo*** B levels genetic variability , d ) the lipoproteine lipase ( LPL ) gene was responsible for 6.5 % of the triglycerides variability , e ) the apo E and LPL 447 polymorphisms influence in conjunction lipid parameters .	parallel	0
4215	10389759	7124;3569	tumor necrosis factor-alpha;IL-6	The CAOV-3 cell line spontaneously secreted ***IL-6*** , which was ***enhanced*** by ***tumor necrosis factor-alpha*** ( 877 + / - 89 vs. 8,452 + / - 1,762 pg/ml , x + / - sd , p < 0.01 ) .	positive	0
4216	10389762	374;4318	amphiregulin;MMP-9	In a previous study , we have shown that EGF and ***amphiregulin*** ***upregulate*** ***MMP-9*** in metastatic SKBR-3 cells but have no effect on MMP-2 secretion .	positive	1
4217	10389762	1950;4318	EGF;MMP-9	In a previous study , we have shown that ***EGF*** and amphiregulin ***upregulate*** ***MMP-9*** in metastatic SKBR-3 cells but have no effect on MMP-2 secretion .	positive	1
4218	10389763	3082;4313	hepatocyte growth factor;matrix metalloproteinase-2	***Regulation*** of ***matrix metalloproteinase-2*** ( MMP-2 ) by ***hepatocyte growth factor/scatter factor*** ( HGF/SF ) in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP .	target	1
4219	10389764	4233;3569	c-MET;HGF	Moreover , these cells express mRNA for both ***HGF*** and its ***receptor*** ***c-MET*** , suggesting that this autocrine loop might contribute to the invasiveness of the tumour from which CAL 72 originated .	parallel	1
4220	10389906	7048;7040	TbetaR-II;TGF-beta	TGF-beta exerts its antiproliferative effect via the ***TGF-beta*** type II ***receptor*** ( ***TbetaR-II*** ) .	parallel	1
4221	10389937	1948;4914	EFNB2;TrkA	High-level expression of EPHB6 , ***EFNB2*** , and EFNB3 is ***associated*** with low tumor stage and high ***TrkA*** expression in human neuroblastomas .	parallel	0
4222	10389937	1949;4914	EFNB3;TrkA	High-level expression of EPHB6 , EFNB2 , and ***EFNB3*** is ***associated*** with low tumor stage and high ***TrkA*** expression in human neuroblastomas .	parallel	0
4223	10389937	2051;4914	EPHB6;TrkA	High-level expression of ***EPHB6*** , EFNB2 , and EFNB3 is ***associated*** with low tumor stage and high ***TrkA*** expression in human neuroblastomas .	parallel	0
4224	10389937	4914;1948	TrkA;EFNB2	Expression of ***TrkA*** , a well-established prognostic marker of favorable NB , was positively ***correlated*** with EPHB6 , ***EFNB2*** , and EFNB3 expression ( P < 0.0001 , P = 0.0019 , and P = 0.0001 , respectively ) .	positive	0
4225	10389937	4914;1949	TrkA;EFNB3	Expression of ***TrkA*** , a well-established prognostic marker of favorable NB , was positively ***correlated*** with EPHB6 , EFNB2 , and ***EFNB3*** expression ( P < 0.0001 , P = 0.0019 , and P = 0.0001 , respectively ) .	positive	0
4226	10389937	4914;2051	TrkA;EPHB6	Expression of ***TrkA*** , a well-established prognostic marker of favorable NB , was positively ***correlated*** with ***EPHB6*** , EFNB2 , and EFNB3 expression ( P < 0.0001 , P = 0.0019 , and P = 0.0001 , respectively ) .	positive	0
4227	10389988	3458;6275	IFN-gamma;S100A4	The present study demonstrates that interferon gamma ( ***IFN-gamma*** ) , but not IFN-alpha and IFN-beta , ***down-regulates*** the ***S100A4*** mRNA level in colon adenocarcinoma WiDr cells in time - and dose-dependent manners .	negative	1
4228	10389988	3458;6275	IFN-gamma;S100A4	***IFN-gamma*** also strongly ***suppressed*** the ***S100A4*** mRNA expression in HT-29 cells , but weakly in Colo201 cells .	negative	1
4229	10389988	3458;6275	IFN-gamma;S100A4	Flow cytometric analysis revealed that the level of the IFN-gamma receptor expression in Colo201 cells was lower than that in WiDr and HT-29 cells , suggesting that the ***suppression*** of the ***S100A4*** expression by ***IFN-gamma*** depends on the amount of cell surface IFN-gamma receptor protein .	negative	1
4230	10390120	308;2152	annexin V;Tissue factor	The phosphatidylserine-binding protein ***annexin V*** ***decreased*** ***Tissue factor*** activity on both ionophore-treated and untreated cells , reflecting the role of phosphatidylserine in Tissue factor activity .	negative	0
4231	10390359	7320;5610	E2 protein;PKR	***Inhibition*** of the interferon-inducible protein kinase ***PKR*** by HCV ***E2 protein*** .	negative	1
4232	10390537	5896;5897	RAG1;RAG2	Previous studies have shown that RAG1 alone is capable of binding to the RSS , whereas RAG2 only binds as a ******RAG1/RAG2****** ***complex*** .	parallel	1
4233	10390537	3148;5896	HMG2;RAG1	The high mobility group protein ***HMG2*** is stably incorporated into the recombinant RAG1/RSS complex and can ***increase*** the affinity of ***RAG1*** for the RSS in the absence of RAG2 .	positive	0
4234	10390541	6732;5619	SR protein-specific kinase 1;protamine 1	***SR protein-specific kinase 1*** is highly expressed in testis and ***phosphorylates*** ***protamine 1*** .	target	1
4235	10390548	1520;2247	cathepsin S;bFGF	Also , when expressed in endothelial cells , ***cathepsin S*** autocrinely ***attenuates*** the basic fibroblast growth factor ( ***bFGF*** ) - mediated binding of FGF receptor containing cells to endothelial cells , by acting on basement membrane proteoglycans .	negative	0
4236	10390549	4803;1520	NGF;cathepsin S	RESULTS : Basic FGF and ***NGF*** treatment of macrophages and microglia significantly ***increased*** the levels of ***cathepsin S*** , B , and L mRNAs ( 2 - to 5-fold ) .	positive	0
4237	10390549	1520;4155	cathepsin S;myelin basic protein	Recombinant human ***cathepsin S*** was able to ***degrade*** ***myelin basic protein*** and monomeric and dimeric amyloid beta peptide at both acidic and neutral pH , as well as to process human amyloid precursor protein generating amyloidogenic fragments .	negative	0
4238	10391095	3553;3569	IL-1beta;IL-6	In the conditioned medium , marked ***IL-6*** secretion was ***induced*** from WI-38 cells by ***IL-1beta*** or TNF-alpha .	target	1
4239	10391095	7124;3569	TNF-alpha;IL-6	In the conditioned medium , marked ***IL-6*** secretion was ***induced*** from WI-38 cells by IL-1beta or ***TNF-alpha*** .	target	1
4240	10391125	847;4790	catalase;NF-kappaB	This activation of ***NF-kappaB*** was ***decreased*** by a metal chelator , diethylene triaminepentaacetic acid or a H2O2 scavenger , ***catalase*** , but was increased by superoxide dismutase .	negative	0
4241	10391247	6885;51701	TAK1;NLK	Here we show that ***TAK1*** activation ***stimulates*** ***NLK*** activity and downregulates transcriptional activation mediated by beta-catenin and TCF .	positive	0
4242	10391249	25;7161	c-Abl;p73	The tyrosine kinase ***c-Abl*** ***regulates*** ***p73*** in apoptotic response to cisplatin-induced DNA damage .	target	1
4243	10391249	25;7161	c-Abl;p73	The half-life of p73 is prolonged by cisplatin and by co-expression with c-Abl tyrosine kinase ; the apoptosis-inducing function of ***p73*** is also ***enhanced*** by the ***c-Abl*** kinase .	positive	0
4244	10391250	7161;25	p73;c-Abl	We find that ***p73*** is a ***substrate*** of the ***c-Abl*** kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation .	parallel	1
4245	10391251	25;7161	c-Abl;p73	***p73*** is ***regulated*** by tyrosine kinase ***c-Abl*** in the apoptotic response to DNA damage .	target	1
4246	10391251	25;7161	c-Abl;p73	Here we show that ***c-Abl*** ***binds*** to ***p73*** in cells , interacting through its SH3 domain with the carboxy-terminal homo-oligomerization domain of p73 .	parallel	1
4247	10391251	25;7161	c-Abl;p73	This ***regulation*** of ***p73*** by ***c-Abl*** in response to DNA damage is also demonstrated by a failure of ionizing-radiation-induced apoptosis after disruption of the c-Abl-p73 interaction .	target	1
4248	10391251	7161;25	p73;c-Abl	This regulation of p73 by c-Abl in response to DNA damage is also demonstrated by a failure of ionizing-radiation-induced apoptosis after disruption of the ******c-Abl-p73****** ***interaction*** .	parallel	1
4249	10391282	3082;4233	hepatocyte growth factor;c-Met	BACKGROUND : ***hepatocyte growth factor*** ( HGF ) , a ***ligand*** for the ***c-Met*** receptor tyrosine kinase , plays a role as organotrophic factor for regeneration of various organs .	parallel	1
4250	10391366	4915;627	trkB;brain-derived neurotrophic factor	Recent studies have suggested that ***brain-derived neurotrophic factor*** ( BNDF ) and its ***receptor*** , ***trkB*** , may provide neuroprotection following injury to the central nervous system .	parallel	1
4251	10391562	5627;7301	protein S;Tyro3	***protein S*** also acts as a mitogen on distinct cell types and is a ***ligand*** for ***Tyro3*** , a member of the Axl family of oncogenic receptor tyrosine kinases .	parallel	1
4252	10391675	1111;995	hChk1;Cdc25C	Taken together with the findings that phosphorylation of Cdc25C on serine 216 is increased at the S to M phase , it is suggested that at this particular phase of the cell cycle , even in the absence of DNA damage , ***hChk1*** ***phosphorylates*** ***Cdc25C*** on serine 216 , which is considered to be a prerequisite for the G2/M checkpoint .	target	1
4253	10391681	355;5601	Fas;JNK2	***Fas*** ligation in the presence of cycloheximide ***induced*** Jun N-terminal kinase 1 ( JNK1 ) and ***JNK2*** phosphorylation , caspase activation and cell death in the IL-3-dependent cell line BAF3 .	target	1
4254	10391681	355;5599	Fas;Jun N-terminal kinase	***Fas*** ligation in the presence of cycloheximide ***induced*** ***Jun N-terminal kinase*** 1 ( JNK1 ) and JNK2 phosphorylation , caspase activation and cell death in the IL-3-dependent cell line BAF3 .	target	1
4255	10391681	355;5599	Fas;JNK	M3/6 prevented ***Fas*** ***stimulation*** of ***JNK*** , but did not affect Fas-mediated caspase activation or cell death , demonstrating that JNK activation is not required for these processes .	positive	0
4256	10391843	356;355	FasL;Fas	***Fas*** ***ligand*** ( ***FasL*** ) induces apoptotic death of activated lymphocytes that express its cell surface receptor , FasR ( CD95/APO-1 ) .	parallel	1
4257	10391889	1432;1958	p38;egr-1	We conclude that ***egr-1*** induction by anisomycin is ***mediated*** by ***p38/SAPK2*** and probably by MSK1 .	target	0
4258	10391889	5600;1958	SAPK2;egr-1	We conclude that ***egr-1*** induction by anisomycin is ***mediated*** by ***p38/SAPK2*** and probably by MSK1 .	target	0
4259	10391889	1432;1958	p38;egr-1	Using mutants of the egr-1 promoter , we demonstrate that a distal cAMP-responsive element ( CRE ; nucleotides -134 to -126 ) is necessary to control ***egr-1*** ***induction*** by ***p38/SAPK2*** .	target	1
4260	10391889	5600;1958	SAPK2;egr-1	Using mutants of the egr-1 promoter , we demonstrate that a distal cAMP-responsive element ( CRE ; nucleotides -134 to -126 ) is necessary to control ***egr-1*** ***induction*** by ***p38/SAPK2*** .	target	1
4261	10391891	6667;6596	Sp1;helicase-like transcription factor	Functional ***interactions*** between ***Sp1*** or Sp3 and the ***helicase-like transcription factor*** mediate basal expression from the human plasminogen activator inhibitor-1 gene .	parallel	1
4262	10391896	7124;4790	tumor necrosis factor alpha;NF-kappaB	***NF-kappaB*** ***activation*** by ***tumor necrosis factor alpha*** ( TNFalpha ) provides a survival signal that impairs the TNFalpha-induced apoptotic response .	positive	1
4263	10391896	5074;5970	Par-4;p65	We show here that expression of ***Par-4*** ***inhibits*** the TNFalpha-induced nuclear translocation of ***p65*** as well as the kappaB-dependent promoter activity .	negative	1
4264	10391900	4831;4609	NDPK-B;c-myc	We propose a mechanism through which human ***NDPK-B*** could ***stimulate*** transcription of ***c-myc*** or possibly other genes involved in cellular differentiation .	positive	0
4265	10391903	9846;2885	Gab2;Grb2	Upon tyrosine phosphorylation , ***Gab2*** physically ***interacts*** with Shp2 tyrosine phosphatase and ***Grb2*** adapter protein .	parallel	1
4266	10391903	9846;5781	Gab2;Shp2	Upon tyrosine phosphorylation , ***Gab2*** physically ***interacts*** with ***Shp2*** tyrosine phosphatase and Grb2 adapter protein .	parallel	1
4267	10391919	10612;4644	BERP;myosin Va	This interaction was confirmed by immunoprecipitation , which also demonstrated that ***BERP*** could ***associate*** with ***myosin Va*** , the product of the dilute gene .	parallel	0
4268	10391928	652;3726	BMP2/4;JunB	***BMP2/4*** rapidly ***induced*** transcript levels of the homeobox genes Msx-1 and Msx-2 and the proto-oncogene ***JunB*** , whereas c-jun transcripts displayed delayed albeit prolonged increase .	target	1
4269	10391928	652;3725	BMP2/4;c-jun	***BMP2/4*** rapidly ***induced*** transcript levels of the homeobox genes Msx-1 and Msx-2 and the proto-oncogene JunB , whereas ***c-jun*** transcripts displayed delayed albeit prolonged increase .	target	1
4270	10391928	652;3397	BMP4;Id1	Besides Id3 , also the ***Id1*** and Id2 genes were ***activated*** by ***BMP4*** in both ES cells and a range of different cell lines .	positive	1
4271	10391928	652;3398	BMP4;Id2	Besides Id3 , also the Id1 and ***Id2*** genes were ***activated*** by ***BMP4*** in both ES cells and a range of different cell lines .	positive	1
4272	10391929	183;6774	angiotensin II;STAT3	Regulation of ***angiotensin II-induced*** ***phosphorylation*** of ***STAT3*** in vascular smooth muscle cells .	target	1
4273	10391929	6714;6774	c-Src;STAT3	In the present study , using specific enzyme inhibitors and antisense oligonucleotides , we show that Ang II-induced tyrosine phosphorylation and nuclear translocation of ***STAT3*** in VSMCs is ***mediated*** by p60 ***c-Src*** , whereas tyrosine dephosphorylation is mediated by calcineurin .	target	0
4274	10391929	5524;6774	PP2A;STAT3	***PP2A*** translocates to the nucleus in response to Ang II stimulation of VSMCs and forms a ***complex*** with ***STAT3*** in an Ang II-dependent manner .	parallel	1
4275	10391939	177;3146	RAGE;amphoterin	Moreover , dominant negative Rac and Cdc42 but not dominant negative Ras inhibit the extension of neurites induced by ******RAGE-amphoterin****** ***interaction*** .	parallel	1
4276	10391943	11221;5594	MKP-5;p38	***MKP-5*** ***binds*** to ***p38*** and SAPK/JNK , but not to MAPK/ERK , and inactivates p38 and SAPK/JNK , but not MAPK/ERK .	parallel	1
4277	10391943	11221;5599	MKP-5;JNK	***MKP-5*** binds to p38 and SAPK/JNK , but not to MAPK/ERK , and ***inactivates*** p38 and ***SAPK/JNK*** , but not MAPK/ERK .	negative	1
4278	10391943	11221;5594	MKP-5;p38	***MKP-5*** binds to p38 and SAPK/JNK , but not to MAPK/ERK , and ***inactivates*** ***p38*** and SAPK/JNK , but not MAPK/ERK .	negative	1
4279	10391943	11221;5601	MKP-5;SAPK	***MKP-5*** binds to p38 and SAPK/JNK , but not to MAPK/ERK , and ***inactivates*** p38 and ***SAPK/JNK*** , but not MAPK/ERK .	negative	1
4280	10391950	7048;7040	TbetaR-II;TGF-beta	TGF-beta stimulated Man-6-P / IGF-II receptor-mediated uptake ( approximately 2-fold after 12 h treatment ) of exogenous beta-glucuronidase in Mv1Lu cells and type II ***TGF-beta*** ***receptor*** ( ***TbetaR-II*** ) - defective mutant cells ( DR26 cells ) but not in type I TGF-beta receptor ( TbetaR-I ) - defective mutant cells ( R-1B cells ) and human colorectal carcinoma cells ( RII-37 cells ) expressing TbetaR-I and TbetaR-II but lacking TbetaR-V .	parallel	1
4281	10392359	3486;3479	IGFBP-3;IGF-I	***IGFBP-3*** levels ***correlated*** positively with ***IGF-I*** ( r = 0.44 , p < 0.005 ) , and free IGF-I levels ( r = 0.37 , p = 0.05 ) in the obese children .	positive	0
4282	10392633	4193;7157	mdm-2;p53	***mdm-2*** expression ***correlates*** with wild-type ***p53*** status in esophageal adenocarcinoma .	parallel	0
4283	10392758	3586;1234	IL-10;CCR5	***IL-10*** ***up-regulates*** ***CCR5*** gene expression in human monocytes .	positive	1
4284	10392758	3586;1234	IL-10;CCR5	Pretreatment of monocytes with actinomycin D prevented the IL-10-induced effect , suggesting a transcriptional mechanism for ***CCR5*** ***up-regulation*** by ***IL-10*** .	positive	1
4285	10392758	3586;1234	IL-10;CCR5	Taken together , our data indicate that ***IL-10*** can ***modulate*** ***CCR5*** expression and function .	target	0
4286	10392899	1958;5243	EGR1;MDR1	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate ( TPA ) increases transcription of the MDR1 gene and activates the MDR1 promoter , and that promoter activation by TPA requires ***binding*** of the zinc finger transcription factor ***EGR1*** to specific ***MDR1*** promoter sequences ( C.	parallel	1
4287	10392899	5243;1958	MDR1;EGR1	Inhibition is likely a direct effect of WT1 binding to the MDR1 promoter because : ( a ) WT1 expression does not inhibit the increase in EGR1 after TPA treatment ; ( b ) inhibition by WT1 requires the zinc finger domain ; ( c ) WT1 binds to ***MDR1*** promoter sequences that ***bind*** ***EGR1*** and are responsive to TPA ; and ( d ) there is an inverse correlation between WT1 protein expression and MDR1 expression and promoter activity .	parallel	1
4288	10392899	1958;5243	EGR1;MDR1	These results suggest that the MDR1 gene is a target for regulation by WT1 and suggest mechanisms by which ***MDR1*** may be ***regulated*** by WT1 and ***EGR1*** during normal and aberrant hematopoiesis .	target	1
4289	10392902	1027;983	p27Kip1;CDK1	Cyclin/cyclin-dependent kinase ( CDK ) complexes immunoprecipitated with p27Kip1 are differentially modified by DXM addition : ( a ) G1 kinasic complexes ( cyclin D/CDK4 or CDK6 ) associated with p27Kip1 are strongly decreased by DXM , ( b ) S-phase complexes ( CDK2/cyclin E and A ) remained stable or increased , and ( c ) the ***association*** of ***p27Kip1*** with the phosphorylated forms of ***CDK1*** is increased by DXM .	parallel	0
4290	10392903	993;1017	cdc25A;cdk2	Rather , expression of cyclin A , which regulates cdk2 activity , and the ***cdc25A*** and cdc25B phosphatases , which are thought to ***activate*** ***cdk2*** , was significantly reduced at both the RNA and protein levels in response to E2 expression .	positive	1
4291	10392903	993;1017	cdc25A;cdk2	Rather , expression of cyclin A , which ***regulates*** ***cdk2*** activity , and the ***cdc25A*** and cdc25B phosphatases , which are thought to activate cdk2 , was significantly reduced at both the RNA and protein levels in response to E2 expression .	target	1
4292	10392903	7320;993	E2 protein;cdc25A	The ***E2 protein*** ***reduced*** expression of ***cdc25A*** and cdc25B in both HT-3 and HeLa cells , but not in cells that were not growth-inhibited by the E2 protein .	negative	1
4293	10392903	7320;994	E2 protein;cdc25B	The ***E2 protein*** ***reduced*** expression of cdc25A and ***cdc25B*** in both HT-3 and HeLa cells , but not in cells that were not growth-inhibited by the E2 protein .	negative	1
4294	10393052	7422;3383	VEGF;ICAM-1	***VEGF*** ***increases*** retinal vascular ***ICAM-1*** expression in vivo .	positive	0
4295	10393052	7422;3383	VEGF;ICAM-1	RESULTS : ***VEGF*** ***increased*** capillary endothelial cell ***ICAM-1*** levels in a dose - and time-dependent manner ( 6-24 hours , plateau after 6 hours ; EC50 , 25 ng/ml ) .	positive	0
4296	10393052	7422;3383	VEGF;ICAM-1	CONCLUSIONS : ***VEGF*** ***increases*** retinal vascular ***ICAM-1*** expression .	positive	0
4297	10393079	1535;1536	p22phox;gp91phox	It is commonly assumed that activation of the superoxide-generating NADPH oxidase requires the formation of a stable complex between flavocytochrome b-245 ( the ******gp91phox/p22phox****** ***heterodimer*** ) and the cytosolic cofactors p47phox , p67phox and Rac2 .	parallel	1
4298	10393085	6418;3725	I2PP2A;c-Jun	Expression of ***I2PP2A*** , an inhibitor of protein phosphatase 2A , ***induces*** ***c-Jun*** and AP-1 activity .	target	1
4299	10393085	6418;5524	I2PP2A;PP2A	Transient expression of ***I2PP2A*** , a potent ***inhibitor*** of protein phosphatase 2A ( ***PP2A*** ) , in HEK-293 cells increased the concentration and DNA binding of the proto-oncogene c-Jun .	negative	1
4300	10393085	6418;3725	I2PP2A;proto-oncogene c-Jun	Transient expression of ***I2PP2A*** , a potent inhibitor of protein phosphatase 2A ( PP2A ) , in HEK-293 cells ***increased*** the concentration and DNA binding of the ***proto-oncogene c-Jun*** .	positive	0
4301	10393113	4916;4908	TrkC;neurotrophin-3	***neurotrophin-3*** and its ***receptor*** ***TrkC*** are expressed during the development of the mammalian cerebral cortex .	parallel	1
4302	10393114	392255;9241	GDF6;noggin	We demonstrate that ***GDF6*** ***binds*** directly to the neural inducer ***noggin*** .	parallel	1
4303	10393114	650;392255	BMP2;GDF6	Furthermore , we find that ***GDF6*** and ***BMP2*** can form ***heterodimers*** and the process seems to require cotranslation of the proteins in the same cells .	parallel	1
4304	10393175	836;317	procaspase-3;Apaf-1	We also show that procaspase-9 can ***recruit*** ***procaspase-3*** to the ***Apaf-1-procaspase-9*** complex .	target	0
4305	10393178	1435;1436	CSF-1;CSF-1R	Colony-stimulating factor-1 ( ***CSF-1*** ) ***activation*** of the CSF-1 receptor ( ***CSF-1R*** ) causes Cbl protooncoprotein tyrosine phosphorylation , Cbl-CSF-1R association and their simultaneous multiubiquitination at the plasma membrane .	positive	1
4306	10393178	1435;1436	CSF-1;CSF-1R	Their CSF-1Rs fail to exhibit multiubiquitination and a second wave of tyrosine phosphorylation previously suggested to be involved in preparation of the ******CSF-1-CSF-1R****** ***complex*** for endocytosis .	parallel	1
4307	10393178	1435;1436	CSF-1;CSF-1R	Consistent with this result , Cbl - / - macrophage cell surface ******CSF-1-CSF-1R****** ***complexes*** are internalized more slowly , yet are still lysosomally degraded , and the CSF-1 utilization by Cbl - / - macrophages is reduced approximately 2-fold .	parallel	1
4308	10393181	5595;821	extracellular-signal regulated kinase-1;calnexin	Analysis by two-dimensional phosphopeptide maps revealed that ***calnexin*** was in vitro ***phosphorylated*** in isolated microsomes by casein kinase 2 ( CK2 ) and ***extracellular-signal regulated kinase-1*** ( ERK-1 ) at sites corresponding to those for in vivo phosphorylation .	target	1
4309	10393181	821;5595	calnexin;ERK-1	Taken together with studies revealing ***calnexin*** ***association*** with CK2 and ***ERK-1*** , a model is proposed whereby phosphorylation of calnexin leads to a potential increase in glycoprotein folding close to the translocon .	parallel	0
4310	10393185	1616;5077	Daxx;Pax3	In this report we demonstrate that human ***Daxx*** ( hDaxx ) ***interacts*** with ***Pax3*** in vivo and with DNA-bound Pax3 in vitro .	parallel	1
4311	10393198	7374;5111	UNG2;PCNA	PCNA and replication protein A ( RPA ) co-localize with UNG2 in replication foci , and a direct molecular ***interaction*** of ***UNG2*** with ***PCNA*** ( one binding site ) and RPA ( two binding sites ) was demonstrated using two-hybrid assays , a peptide SPOT assay and enzyme-linked immunosorbent assays .	parallel	1
4312	10393217	6646;338	ACAT;ApoB	We conclude that inhibition of hepatic ***ACAT*** by avasimibe ***reduces*** both plasma VLDL and LDL ***ApoB*** concentrations , primarily by decreasing ApoB secretion .	positive	1
4313	10393217	6646;338	ACAT;apolipoprotein B	Inhibition of ***ACAT*** by avasimibe ***decreases*** both VLDL and LDL ***apolipoprotein B*** production in miniature pigs .	positive	0
4314	10393248	1457;5435	CKII;RPB6	In this study , we investigated in vitro ***phosphorylation*** of rat ***RPB6*** by casein kinase II ( ***CKII*** ) , a pleiotropic regulator of numerous cellular proteins .	target	1
4315	10393248	1457;5435	CKII;RPB6	Therefore , ***RPB6*** was implied to be ***phosphorylated*** by ***CKII*** in the nucleus .	target	1
4316	10393530	2353;3725	c-fos;c-jun	The ***association*** between ***c-fos*** and ***c-jun*** expression and estrogen and progesterone receptors is lost in human endometrial cancer .	parallel	0
4317	10393558	5914;6257	RARalpha;retinoid X receptor beta	In gel mobility shift assays , ***heterodimers*** of retinoic acid receptor alpha ( ***RARalpha*** ) and ***retinoid X receptor beta*** ( RXRbeta ) bound specifically to this element .	parallel	1
4318	10393698	6348;1234	MIP-1alpha;CCR5	Moreover , macrophage inflammatory protein-1alpha ( ***MIP-1alpha*** ) , one of the ***ligands*** for ***CCR5*** , was selectively expressed on intralobular bile duct epithelial cells , endothelial cells , and infiltrating macrophages and lymphocytes .	parallel	1
4319	10393810	885;9112	cholecystokinin;mta1	The expression of ***mta1*** was ***up-regulated*** in the pancreas by endogenous ***cholecystokinin*** release and in AR4-2J after induction of cellular differentiation by dexamethasone .	positive	1
4320	10393857	3606;3458	IL-18;IFN-gamma	***IL-18*** , primarily a monocyte product , ***promotes*** the secretion of ***IFN-gamma*** , which stimulates Mig and RANTES expression .	positive	0
4321	10393857	3458;4283	IFN-gamma;Mig	IL-18 , primarily a monocyte product , promotes the secretion of ***IFN-gamma*** , which ***stimulates*** ***Mig*** and RANTES expression .	positive	0
4322	10393857	3458;6352	IFN-gamma;RANTES	IL-18 , primarily a monocyte product , promotes the secretion of ***IFN-gamma*** , which ***stimulates*** Mig and ***RANTES*** expression .	positive	0
4323	10393859	4792;4790	IkappaBalpha;NF-kappaB	In addition , NO attenuates signal-initiated degradation of ***IkappaBalpha*** , an intracellular ***inhibitor*** of ***NF-kappaB*** , and blocks the DNA binding activity of the NF-kappaB p50/p50 homodimer and p50/p65 heterodimer .	negative	1
4324	10393859	4790;5970	p50;p65	In addition , NO attenuates signal-initiated degradation of IkappaBalpha , an intracellular inhibitor of NF-kappaB , and blocks the DNA binding activity of the NF-kappaB p50/p50 homodimer and ******p50/p65****** ***heterodimer*** .	parallel	1
4325	10393926	983;891	Cdc2;cyclin B1	Mitosis is triggered in vertebrate cells by the ******cyclin B1-Cdc2****** ***complex*** .	parallel	1
4326	10393932	836;356	caspase-3;CD95L	Inhibition of ***caspase-3*** , a downstream protease in the CD95 signaling pathway , ***blocked*** both ***CD95L*** and UVB-induced apoptosis , whereas blockage of caspase-8 , the most proximal caspase , inhibited CD95L-mediated apoptosis completely , but UVB-induced apoptosis only partially .	positive	0
4327	10393933	999;1500	E-cadherin;p120	Expression of exogenous ***E-cadherin*** ***down-regulated*** nuclear ***p120*** ( ctn ) whereas activation of protein kinase C increased the level of nuclear p120 ( ctn ) .	negative	1
4328	10393935	596;11083	Bcl-2;DIO-1	***DIO-1*** apoptotic induction is ***prevented*** by caspase inhibitors and ***Bcl-2*** overexpression .	negative	0
4329	10393951	3565;3567	IL-4;IL-5	Moreover , ***IL-4*** , which by itself had no visible effect on human MC , ***enhanced*** the release of histamine , leukotriene C4 , and ***IL-5*** in MC triggered by IgE receptor crosslinking .	positive	0
4330	10393956	962;7124	CD48;tumor necrosis factor alpha	The mast cell ***tumor necrosis factor alpha*** response to FimH-expressing Escherichia coli is ***mediated*** by the glycosylphosphatidylinositol-anchored molecule ***CD48*** .	target	0
4331	10393958	7408;58	VASP;ActA	***VASP*** , which is expressed in most cell types and in particularly high levels in human platelets , ***binds*** to profilin , zyxin , vinculin , F-actin , and the Listeria monocytogenes surface protein ***ActA*** .	parallel	1
4332	10393958	7408;7414	VASP;vinculin	***VASP*** , which is expressed in most cell types and in particularly high levels in human platelets , ***binds*** to profilin , zyxin , ***vinculin*** , F-actin , and the Listeria monocytogenes surface protein ActA .	parallel	1
4333	10393958	7408;7791	VASP;zyxin	***VASP*** , which is expressed in most cell types and in particularly high levels in human platelets , ***binds*** to profilin , ***zyxin*** , vinculin , F-actin , and the Listeria monocytogenes surface protein ActA .	parallel	1
4334	10393981	5741;1594	PTH;CYP27B1	***PTH*** ***increased*** the expression of renal ***CYP27B1*** mRNA only in vitamin D-deficient hypocalcemic TPTX rats .	positive	0
4335	10394054	3600;3586	IL-15;IL-10	As to immunoglobulin secretion , ***IL-15*** was able to ***potentiate*** the stimulatory effect of ***IL-10*** .	positive	0
4336	10394363	6844;6810	VAMP2;syntaxin 4	Insulin-stimulated glucose transport and GLUT4 translocation require regulated ***interactions*** between the v-SNARE , ***VAMP2*** , and the t-SNARE , ***syntaxin 4*** .	parallel	1
4337	10394363	10490;6810	v-SNARE;syntaxin 4	Insulin-stimulated glucose transport and GLUT4 translocation require regulated ***interactions*** between the ***v-SNARE*** , VAMP2 , and the t-SNARE , ***syntaxin 4*** .	parallel	1
4338	10394363	10490;6844	v-SNARE;VAMP2	Insulin-stimulated glucose transport and GLUT4 translocation require regulated ***interactions*** between the ***v-SNARE*** , ***VAMP2*** , and the t-SNARE , syntaxin 4 .	parallel	1
4339	10394363	6814;6810	syntaxin 4-binding protein;syntaxin 4	We have isolated a novel ***syntaxin 4-binding protein*** , Synip , which specifically ***interacts*** with ***syntaxin 4*** .	parallel	1
4340	10395064	183;1958	angiotensin II;Egr-1	***Induction*** of ***Egr-1*** mRNA and protein by endothelin 1 , ***angiotensin II*** and norepinephrine in neonatal cardiac myocytes .	target	1
4341	10395064	1906;1958	endothelin 1;Egr-1	***Induction*** of ***Egr-1*** mRNA and protein by ***endothelin 1*** , angiotensin II and norepinephrine in neonatal cardiac myocytes .	target	1
4342	10395089	1230;6348	CC-CKR1;MIP-1 alpha	Identification of amino acids involved in the binding of hMIP-1 alpha to ***CC-CKR1*** , a ***MIP-1 alpha*** ***receptor*** found on neutrophils .	parallel	1
4343	10395179	196;1543	Ah receptor;CYP1	Expression of the ***Ah receptor*** and Arnt which are involved in the transcriptional ***activation*** of the ***CYP1*** genes was also studied .	positive	1
4344	10395179	405;1543	Arnt;CYP1	Expression of the Ah receptor and ***Arnt*** which are involved in the transcriptional ***activation*** of the ***CYP1*** genes was also studied .	positive	1
4345	10395199	652070;3265	scFv;p21Ras	Primers designed for rat Vlambda amplification allowed the cloning of a functional ***scFv*** that could ***bind*** ***p21Ras*** .	parallel	1
4346	10395199	652070;3265	scFv;p21Ras	The kinetics of ***interaction*** of purified Y238 ***scFv*** with the ***p21Ras*** protein was evaluated by BIAcore with a NTA sensor chip and gave an apparent affinity constant in the nanomolar range ( K ( D ) = 4.58 + / -0.63 nM ) .	parallel	1
4347	10395217	3782;3738	hSKCa3;potassium channel	A possible ***association*** between the small conductance calcium-regulated ***potassium channel*** gene , ***hSKCa3*** , and schizophrenia has recently been described by Chandy et al using a case-control design with patients with schizophrenia ( n = 141 ) and matched controls ( n = 158 ) .	parallel	0
4348	10395289	3949;4018	LDLR;lipoprotein	This study examines the effect of mutation of the low-density ***lipoprotein*** ***receptor*** ( ***LDLR*** ) on cholesterol metabolism , and especially lipoprotein-derived cholesteryl ester uptake , in murine ovarian granulosa cells .	parallel	1
4349	10395292	2822;5329	GPI-PLD;uPAR	We show that ***uPAR*** release is ***catalyzed*** by cellular GPI-specific phospholipase D ( ***GPI-PLD*** ) , an enzyme cleaving the GPI anchor of the receptor .	positive	1
4350	10395292	2822;5329	GPI-PLD;uPAR	We found that ***GPI-PLD*** also ***regulated*** ***uPAR*** expression , possibly by releasing a GPI-anchored growth factor .	target	1
4351	10395322	958;959	CD40;CD40 ligand	The action of T helper cells in CTL priming is mediated by ******CD40-CD40 ligand****** ***interactions*** .	parallel	1
4352	10395405	4883;2981	guanylate cyclase-C;uroguanylin	Membrane ***guanylate cyclase-C*** is an intestinal ***receptor*** for guanylin and ***uroguanylin*** that is responsible for stimulation of Cl - and HCO3 - secretion into the intestinal lumen .	parallel	1
4353	10395457	3336;3329	GroES;GroEL	The observed variations in sulfhydryl accessibility are consistent with mechanisms that suggest ***binding*** of ***GroES*** to ***GroEL*** differs from the binding of substrate protein to GroEL , and that the binding of Mg2 + or Mg-adenine nucleotides results in conformational changes in GroEL .	parallel	1
4354	10395644	355;3606	Fas;IL-18	Since IL-18 enhances Fas ligand ( FasL ) expression on NK cell lines , the ***IL-18*** antitumor effects could be ***mediated*** by FasL-induced cross-linking of ***Fas*** and subsequent tumor apoptosis .	target	0
4355	10395644	3606;356	IL-18;Fas ligand	Since ***IL-18*** ***enhances*** ***Fas ligand*** ( FasL ) expression on NK cell lines , the IL-18 antitumor effects could be mediated by FasL-induced cross-linking of Fas and subsequent tumor apoptosis .	positive	0
4356	10395651	959;1440	CD40 ligand;G-CSF	Both the soluble form of ***CD40 ligand*** ( sCD40L ) and TNF ***increased*** the level of M-CSF and ***G-CSF*** mRNA .	positive	0
4357	10395651	959;1435	CD40 ligand;M-CSF	Both the soluble form of ***CD40 ligand*** ( sCD40L ) and TNF ***increased*** the level of ***M-CSF*** and G-CSF mRNA .	positive	0
4358	10395652	7097;929	TLR2;CD14	We show that ***TLR2*** ***associates*** with the high-affinity LPS binding protein membrane ***CD14*** to serve as an LPS receptor complex , and that LPS treatment enhances the oligomerization of TLR2 .	parallel	0
4359	10395652	7189;4790	TNF receptor-associated factor 6;NF-kappaB	DN constructs of myeloid differentiation protein , IRAK , ***TNF receptor-associated factor 6*** , and NF-kappaB-inducing kinase , when coexpressed with TLR2 , ***abrogate*** TLR2-mediated ***NF-kappaB*** activation .	negative	0
4360	10395655	959;958	CD40L;CD40	In vivo Ig responses to soluble , haptenated polysaccharide ( PS ) Ags are T cell independent and do not require ***CD40*** ***ligand*** ( ***CD40L*** ) .	parallel	1
4361	10395656	3383;7124	ICAM-1;TNF-alpha	Using rat astrocytes in culture , we report that ***ICAM-1*** binding by specific Abs ***induces*** ***TNF-alpha*** secretion together with phosphorylation of the transcription factor cAMP response element-binding protein .	target	1
4362	10395661	3558;2353	IL-2;c-fos	Herein , we demonstrate that diacylglycerol kinase inhibition has a profound effect on the ***induction*** of the protooncogenes c-myc , ***c-fos*** , and c-raf by ***IL-2*** , whereas expression of bcl-2 and bcl-xL are not affected .	target	1
4363	10395661	3558;4609	IL-2;c-myc	Herein , we demonstrate that diacylglycerol kinase inhibition has a profound effect on the ***induction*** of the protooncogenes ***c-myc*** , c-fos , and c-raf by ***IL-2*** , whereas expression of bcl-2 and bcl-xL are not affected .	target	1
4364	10395661	3558;5894	IL-2;c-raf	Herein , we demonstrate that diacylglycerol kinase inhibition has a profound effect on the ***induction*** of the protooncogenes c-myc , c-fos , and ***c-raf*** by ***IL-2*** , whereas expression of bcl-2 and bcl-xL are not affected .	target	1
4365	10395661	3558;896	IL-2;cyclin D3	When the IL-2-regulated cell cycle control checkpoints are examined in detail , we demonstrate that inhibition of diacylglycerol kinase activation prevents ***IL-2*** ***induction*** of ***cyclin D3*** without affecting p27 down-regulation .	target	1
4366	10395669	3454;3439	hIFNAR;IFN	The human ***IFN-alpha*** ***receptor*** ( ***hIFNAR*** ) is a complex composed of at least two chains , hIFNAR1 and hIFNAR2 .	parallel	1
4367	10395669	3455;3439	hIFNAR2;hIFN	To confirm that residues important for ligand binding are indeed important for IFN signal transduction , we determined the ability of mouse L929 cells expressing ***hIFNAR2*** extracellular domain mutants to ***mediate*** ***hIFN*** signal .	target	0
4368	10395671	958;959	CD40;CD40 ligand	******CD40/CD40 ligand****** ***interactions*** play a key role in the immune responses of B lymphocytes , monocytes , and dendritic cells .	parallel	1
4369	10395671	3718;958	Janus kinase 3;CD40	In contrast , although the ***Janus kinase 3*** tyrosine kinase was ***associated*** with ***CD40*** molecules in both monocytes and resting B cells , Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes , with subsequent induction of STAT5a DNA binding activity in the nucleus .	parallel	0
4370	10395673	7409;5879	Vav;Rac1	This was dependent on ***Vav-mediated*** ***activation*** of ***Rac1*** as a Dbl domain-mutated Vav , inactive Rac N17 , and inactive JNK1 down-regulated the Vav-induced JNK1 or IL-6 responses .	positive	1
4371	10395673	7409;3569	Vav;IL-6	***Vav*** expression , but not expression of domain-mutated Vav , ***increased*** ***IL-6*** secretion from nonimmortalized bone marrow-derived mast cells upon FcepsilonRI engagement .	positive	0
4372	10395678	940;5879	CD28;Rac-1	Here , we show that ***TCR/CD28*** costimulation synergistically ***induces*** ***Rac-1*** GDP/GTP exchange .	target	1
4373	10395678	7535;7409	ZAP-70;Vav	Our findings , obtained by using ZAP-70-negative Jurkat T cells , indicate that CD28 costimulation augments TCR-mediated T cell activation by increasing the ***ZAP-70-mediated*** Tyr ***phosphorylation*** of ***Vav*** .	target	1
4374	10395678	7409;27040	Vav;linker for activation of T cells	CD28 amplifies TCR-induced ZAP-70 activity and ***association*** of ***Vav*** with ZAP-70 and ***linker for activation of T cells*** ( LAT ) .	parallel	0
4375	10395678	7409;7535	Vav;ZAP-70	CD28 amplifies TCR-induced ZAP-70 activity and ***association*** of ***Vav*** with ***ZAP-70*** and linker for activation of T cells ( LAT ) .	parallel	0
4376	10395688	3458;8743	IFN-gamma;TRAIL	CMV infection increased the expression of TRAIL-R1 and -R2 , whereas ***IFN-gamma*** ***down-regulated*** the expression of ***TRAIL-Rs*** on uninfected fibroblasts .	negative	1
4377	10395688	3458;4790	IFN-gamma;NF-kappaB	Moreover , ***IFN-gamma*** significantly ***decreased*** the basal level of ***NF-kappaB*** activation , a known survival factor that inhibits apoptosis .	negative	0
4378	10395791	5727;2735	Ptc;Gli1	We find that excess ***Ptc*** is sufficient to ***inhibit*** expression of ***Gli1*** and ptc1 , suggesting that Sonic hedgehog ( Shh ) can not signal effectively .	negative	1
4379	10395798	8929;1621	NBPhox;DBH	However , ***NBPhox*** substantially ***enhances*** second messenger-mediated activation of the ***DBH*** promoter by forskolin and/or phorbol ester .	positive	0
4380	10395798	8929;2353	NBPhox;c-fos	Furthermore , we found that ***NBPhox*** can also ***enhance*** second messenger-mediated activation of the ***c-fos*** promoter and several enhancers , including cyclic AMP-response element , the binding site for activator protein 1 , and serum-response element .	positive	0
4381	10395864	4018;948	lipoprotein;CD36	Plasmodium falciparum-infected erythrocytes and oxidized low-density ***lipoprotein*** ***bind*** to separate domains of ***CD36*** .	parallel	1
4382	10395864	948;4018	CD36;lipoprotein	The cytoadherence of erythrocytes ( red blood cells ) infected with Plasmodium falciparum ( pRBCs ) to endothelial cells and the uptake of oxidized low-density ***lipoprotein*** ( oxLDL ) by macrophages are both ***mediated*** , in part , by the glycoprotein receptor ***CD36*** .	target	0
4383	10395923	10102;7284	EF-Ts;EF-Tu	The activity of E. coli ***EF-Tu*** but not of EF-Tumt is ***stimulated*** by E. coli ***EF-Ts*** .	positive	0
4384	10395932	6373;2833	CXCL 11;CXCR3	***CXCL 11*** , encoded by the cDNA sequences designated beta-R1 , H-174 , or I-TAC , is a CXC chemokine ***ligand*** for ***CXCR3*** and assumed to be involved in inflammatory diseases characterized by the presence of activated T-cells .	parallel	1
4385	10395955	7124;1435	TNF-alpha;M-CSF	By using a specific ELISA we found that their constitutive secretion of ***M-CSF*** is ***enhanced*** by tumour necrosis factor-alpha ( ***TNF-alpha*** ) .	positive	0
4386	10395972	5443;4160	alpha-melanocyte-stimulating hormone;MC4-R	POMC is the precursor of ***alpha-melanocyte-stimulating hormone*** ( alpha-MSH ) , which ***binds*** to the melanocortin receptor ***MC4-R*** in the brain , decreases appetite , and activates lipid metabolism .	parallel	1
4387	10396029	5617;3479	PRL;IGF-I	***PRL*** completely ***abolished*** the ***IGF-I*** stimulation of alpha-mRNA levels , suggesting a desensitisation of the gill tissue to IGF-I , which may explain the overall anti-SW adaptive effect of PRL .	negative	0
4388	10396036	960;4233	CD44;c-Met	***Cross-talk*** between ***CD44*** and ***c-Met*** in B cells .	parallel	0
4389	10396366	3484;5054	IGFBP-1;PAI-1	RESULTS : After correcting for age , sex and body mass index , concentrations of ***IGFBP-1*** , ***correlated*** with those of HDL-cholesterol ( r = 0.40 ; P < 0.001 ) , triglycerides ( r = -0.24 ; P = 0.04 ) , insulin ( r = -0.39 ; P < 0.001 ) , intact proinsulin ( r = -0.32 ; P = 0.006 ) , des 31,32 proinsulin ( r = -0.40 ; P = 0.001 ) , and with insulin sensitivity ( r = 0.38 ; P = 0.001 ) and ***PAI-1*** activity ( r = -0.24 ; P = 0.05 ) ; IGF-1 levels only correlated with those of HDL-cholesterol ( r = -0.33 ; P = 0.005 ) , and this was not explained by IGFBP-1 or insulin sensitivity .	parallel	0
4390	10396366	3484;5054	IGFBP-1;PAI-1	***IGFBP-1*** concentrations were ***related*** to ***PAI-1*** ac